FlyBase Gene Report: Dmel\CG5347

General Information

Symbol

Dmel\CG5347

Species

D. melanogaster

Name

Annotation Symbol

CG5347

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030578

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Predicted to enable RNA binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in protein polyubiquitination. Predicted to be part of ribonucleoprotein complex. Is expressed in organism. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1) and MKRN2 (makorin ring finger protein 2). (Alliance, FBgn0030578 )

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All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

12F4-12F4

Sequence location

X:14,776,774..14,777,983 [+]

Recombination map

1-49

RefSeq locus

NC_004354 REGION:14776774..14777983

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

enzyme

regulator

receptor

receptor binding

transporter

structural molecule

cytoskeletal binding

DNA binding

RNA binding

transcription factor

small molecule binding

metal ion binding

lipid binding

carbohydrate binding

other molecular_function

molecular function

cell cycle/proliferation

cell organization/biogenesis

transport/localization

development

reproduction

immune system

nervous system process

behavior

response to stimulus

signaling

gene expression

protein metabolism

DNA metabolism

small molecule metabolism

other biological_process

biological process

extracellular region

cytosol

cytoskeleton

mitochondrion

nucleus

chromosome

membrane

cell periphery

cell junction

cell projection

endomembrane system

synapse

macromolecular complex

other cellular_component

cellular component

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables metal ion binding

inferred from electronic annotation with InterPro:IPR000571, InterPro:IPR018957, InterPro:IPR036855

(InterPro Project Members, 2004-)

enables RNA binding

inferred from sequence or structural similarity with UniProtKB:Q9VP20

(Gene Ontology Curators, 2002-)

enables ubiquitin protein ligase activity

inferred from sequence or structural similarity with UniProtKB:Q9UHC7

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000131854

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR045072

(InterPro Project Members, 2004-)

enables ubiquitin-protein transferase activity

inferred from sequence or structural similarity with HGNC:7112

(Gene Ontology Curators, 2002-)

enables zinc ion binding

inferred from sequence model

(Ying et al., 2011)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in protein polyubiquitination

inferred from electronic annotation with InterPro:IPR045072

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with HGNC:7112

(Gene Ontology Curators, 2002-)

involved_in protein ubiquitination

inferred from biological aspect of ancestor with PANTHER:PTN000131854

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of ribonucleoprotein complex

inferred from sequence or structural similarity with UniProtKB:Q9VP20

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Expression Data

Gene ToolKit

The gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.

Category	Common alleles (# stocks)
Classical and Insertion Alleles
Loss of function allele
Amorphic allele
Fluorescently-tagged allele
Transgenic Constructs
UAS RNAi
UAS wild-type cDNA
Untagged genomic rescue
Fluorescently-tagged genomic rescue
Aberrations
Deficiency
Duplication

Alleles, Insertions, Transgenic Constructs, and Aberrations

Variants

Phenotypes

Orthologs

Paralogs

Human Disease Associations

Functional Complementation Data

Interactions

Pathways

Class of Gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-49

Cytogenetic map

12F4-12F4

Sequence location

X:14,776,774..14,777,983 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

12F4-12F4

Limits computationally determined from genome sequence between P{EP}EP1599 and P{EP}EP334&P{EP}EP977

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-49

(FlyBase, 2016)

1-48.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Other Comments

Relationship to Other Genes

Nomenclature History

Synonyms and Secondary IDs (1)

Datasets (0)

External Crossreferences and Linkouts ( 34 )

References (31)

The following external sites may use different assemblies or annotations than FlyBase.

GO Summary Ribbons

Expression Summary Ribbons

4.49

Gene ToolKit

Disease Model Summary Ribbon

Report Sections