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Gene Dmel\CG14407

General Information
Symbol	Dmel\CG14407	Species	D. melanogaster
Name		Annotation symbol	CG14407
Feature type	protein_coding_gene	FlyBase ID	FBgn0030584
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	12F5-12F5	Sequence location	X:14,731,504..14,732,230 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG14407 (FBgn0030584). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: protein disulfide oxidoreductase activity; electron carrier activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: cell redox homeostasis. 3 alleles are reported. The phenotype of these alleles is annotated with: tormogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Glutaredoxin; Monothiol glutaredoxin-related; Thioredoxin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult hindgut, adult Malpighian tubules, adult heart, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1629082_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG14407. Gene sequence location is X:14731504..14732230.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN28030 HFA19593
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 12F5-12F5   Limits computationally determined from genome sequence between P{EP}EP334&P{EP}EP977 and P{EP}hiwEP1305
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG14407 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG14407-RA FBtr0073989  NM_132746   667   159
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG14407-PA   FBpp0073806   17.7   159   8.08     NP_572974   AAF48392
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glutaredoxin (IPR002109) Monothiol glutaredoxin-related (IPR004480) Thioredoxin-like fold (IPR012336)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48392   AY084192 AAL89930   BF500599   BF505232   BI358559   BI570109   BI581297   BI581311   BI581334   BI581337   BI581414   BI581912   BI581944   BI582584   BI589625   BI614938   BI616559   BI618092   BI618352   BI620435   BI620494   BI623407   BI628227   BI633663   BP546968   BP547548   CK135484   CO300211   CO304504   CO318432   CO326491   EC089706   EC202794   EC224493   EC246036   EC256836   FD586209   FD586228   FD586244   FD586284   FD586728   FD587453   FD587496   GH741795   GH746899   GH763219   GH765329   GH766624   GH766713   GH767543
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SXQ5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030584    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030584 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030584 expression level Developmental Stage   Expression Level embryo 00-02hr    4666 embryo 02-04hr    2898 embryo 04-06hr    2223 embryo 06-08hr    2534 embryo 08-10hr    2665 embryo 10-12hr    3858 embryo 12-14hr    1986 embryo 14-16hr    3290 embryo 16-18hr    3205 embryo 18-20hr    3315 embryo 20-22hr    3517 embryo 22-24hr    2650 larva L1    4636 larva L2    4816 larva L3 12hr old    4119 larva L3 puffstage 1-2    2892 larva L3 puffstage 3-6    2314 larva L3 puffstage 7-9    2024 white prepupae new    1710 white prepupae 12hr    1921 white prepupae 24hr    2055 pupae 2d postWPP    2927 pupae 3d postWPP    3892 pupae 4d postWPP    4423 adult male 01day    4816 adult male 05day    5300 adult male 30day    4950 adult female 01day    5213 adult female 05day    3555 adult female 30day    4152 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4666) embryo 02-04hr  (2898) embryo 04-06hr  (2223) embryo 06-08hr  (2534) embryo 08-10hr  (2665) embryo 10-12hr  (3858) embryo 12-14hr  (1986) embryo 14-16hr  (3290) embryo 16-18hr  (3205) embryo 18-20hr  (3315) embryo 20-22hr  (3517) embryo 22-24hr  (2650) larva L1  (4636) larva L2  (4816) larva L3 12hr old  (4119) larva L3 puffstage 1-2  (2892) larva L3 puffstage 3-6  (2314) larva L3 puffstage 7-9  (2024) white prepupae new  (1710) white prepupae 12hr  (1921) white prepupae 24hr  (2055) pupae 2d postWPP  (2927) pupae 3d postWPP  (3892) pupae 4d postWPP  (4423) adult male 01day  (4816) adult male 05day  (5300) adult male 30day  (4950) adult female 01day  (5213) adult female 05day  (3555) adult female 30day  (4152) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4666) embryo 02-04hr  (2898) embryo 04-06hr  (2223) embryo 06-08hr  (2534) embryo 08-10hr  (2665) embryo 10-12hr  (3858) embryo 12-14hr  (1986) embryo 14-16hr  (3290) embryo 16-18hr  (3205) embryo 18-20hr  (3315) embryo 20-22hr  (3517) embryo 22-24hr  (2650) larva L1  (4636) larva L2  (4816) larva L3 12hr old  (4119) larva L3 puffstage 1-2  (2892) larva L3 puffstage 3-6  (2314) larva L3 puffstage 7-9  (2024) white prepupae new  (1710) white prepupae 12hr  (1921) white prepupae 24hr  (2055) pupae 2d postWPP  (2927) pupae 3d postWPP  (3892) pupae 4d postWPP  (4423) adult male 01day  (4816) adult male 05day  (5300) adult male 30day  (4950) adult female 01day  (5213) adult female 05day  (3555) adult female 30day  (4152) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4666 embryo 02-04hr    2898 embryo 04-06hr    2223 embryo 06-08hr    2534 embryo 08-10hr    2665 embryo 10-12hr    3858 embryo 12-14hr    1986 embryo 14-16hr    3290 embryo 16-18hr    3205 embryo 18-20hr    3315 embryo 20-22hr    3517 embryo 22-24hr    2650 larva L1    4636 larva L2    4816 larva L3 12hr old    4119 larva L3 puffstage 1-2    2892 larva L3 puffstage 3-6    2314 larva L3 puffstage 7-9    2024 white prepupae new    1710 white prepupae 12hr    1921 white prepupae 24hr    2055 pupae 2d postWPP    2927 pupae 3d postWPP    3892 pupae 4d postWPP    4423 adult male 01day    4816 adult male 05day    5300 adult male 30day    4950 adult female 01day    5213 adult female 05day    3555 adult female 30day    4152 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4666 embryo 02-04hr    2898 embryo 04-06hr    2223 embryo 06-08hr    2534 embryo 08-10hr    2665 embryo 10-12hr    3858 embryo 12-14hr    1986 embryo 14-16hr    3290 embryo 16-18hr    3205 embryo 18-20hr    3315 embryo 20-22hr    3517 embryo 22-24hr    2650 larva L1    4636 larva L2    4816 larva L3 12hr old    4119 larva L3 puffstage 1-2    2892 larva L3 puffstage 3-6    2314 larva L3 puffstage 7-9    2024 white prepupae new    1710 white prepupae 12hr    1921 white prepupae 24hr    2055 pupae 2d postWPP    2927 pupae 3d postWPP    3892 pupae 4d postWPP    4423 adult male 01day    4816 adult male 05day    5300 adult male 30day    4950 adult female 01day    5213 adult female 05day    3555 adult female 30day    4152 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030584 expression level Developmental Stage   Expression Level embryo 00-02hr    4666 embryo 02-04hr    2898 embryo 04-06hr    2223 embryo 06-08hr    2534 embryo 08-10hr    2665 embryo 10-12hr    3858 embryo 12-14hr    1986 embryo 14-16hr    3290 embryo 16-18hr    3205 embryo 18-20hr    3315 embryo 20-22hr    3517 embryo 22-24hr    2650 larva L1    4636 larva L2    4816 larva L3 12hr old    4119 larva L3 puffstage 1-2    2892 larva L3 puffstage 3-6    2314 larva L3 puffstage 7-9    2024 white prepupae new    1710 white prepupae 12hr    1921 white prepupae 24hr    2055 pupae 2d postWPP    2927 pupae 3d postWPP    3892 pupae 4d postWPP    4423 adult male 01day    4816 adult male 05day    5300 adult male 30day    4950 adult female 01day    5213 adult female 05day    3555 adult female 30day    4152 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4666) embryo 02-04hr  (2898) embryo 04-06hr  (2223) embryo 06-08hr  (2534) embryo 08-10hr  (2665) embryo 10-12hr  (3858) embryo 12-14hr  (1986) embryo 14-16hr  (3290) embryo 16-18hr  (3205) embryo 18-20hr  (3315) embryo 20-22hr  (3517) embryo 22-24hr  (2650) larva L1  (4636) larva L2  (4816) larva L3 12hr old  (4119) larva L3 puffstage 1-2  (2892) larva L3 puffstage 3-6  (2314) larva L3 puffstage 7-9  (2024) white prepupae new  (1710) white prepupae 12hr  (1921) white prepupae 24hr  (2055) pupae 2d postWPP  (2927) pupae 3d postWPP  (3892) pupae 4d postWPP  (4423) adult male 01day  (4816) adult male 05day  (5300) adult male 30day  (4950) adult female 01day  (5213) adult female 05day  (3555) adult female 30day  (4152) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4666) embryo 02-04hr  (2898) embryo 04-06hr  2223 embryo 06-08hr  (2534) embryo 08-10hr  (2665) embryo 10-12hr  (3858) embryo 12-14hr  1986 embryo 14-16hr  (3290) embryo 16-18hr  (3205) embryo 18-20hr  (3315) embryo 20-22hr  (3517) embryo 22-24hr  (2650) larva L1  (4636) larva L2  (4816) larva L3 12hr old  (4119) larva L3 puffstage 1-2  (2892) larva L3 puffstage 3-6  2314 larva L3 puffstage 7-9  2024 white prepupae new  1710 white prepupae 12hr  1921 white prepupae 24hr  2055 pupae 2d postWPP  (2927) pupae 3d postWPP  (3892) pupae 4d postWPP  (4423) adult male 01day  (4816) adult male 05day  (5300) adult male 30day  (4950) adult female 01day  (5213) adult female 05day  (3555) adult female 30day  (4152) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4666 embryo 02-04hr    2898 embryo 04-06hr    2223 embryo 06-08hr    2534 embryo 08-10hr    2665 embryo 10-12hr    3858 embryo 12-14hr    1986 embryo 14-16hr    3290 embryo 16-18hr    3205 embryo 18-20hr    3315 embryo 20-22hr    3517 embryo 22-24hr    2650 larva L1    4636 larva L2    4816 larva L3 12hr old    4119 larva L3 puffstage 1-2    2892 larva L3 puffstage 3-6    2314 larva L3 puffstage 7-9    2024 white prepupae new    1710 white prepupae 12hr    1921 white prepupae 24hr    2055 pupae 2d postWPP    2927 pupae 3d postWPP    3892 pupae 4d postWPP    4423 adult male 01day    4816 adult male 05day    5300 adult male 30day    4950 adult female 01day    5213 adult female 05day    3555 adult female 30day    4152 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4666 embryo 02-04hr    2898 embryo 04-06hr    2223 embryo 06-08hr    2534 embryo 08-10hr    2665 embryo 10-12hr    3858 embryo 12-14hr    1986 embryo 14-16hr    3290 embryo 16-18hr    3205 embryo 18-20hr    3315 embryo 20-22hr    3517 embryo 22-24hr    2650 larva L1    4636 larva L2    4816 larva L3 12hr old    4119 larva L3 puffstage 1-2    2892 larva L3 puffstage 3-6    2314 larva L3 puffstage 7-9    2024 white prepupae new    1710 white prepupae 12hr    1921 white prepupae 24hr    2055 pupae 2d postWPP    2927 pupae 3d postWPP    3892 pupae 4d postWPP    4423 adult male 01day    4816 adult male 05day    5300 adult male 30day    4950 adult female 01day    5213 adult female 05day    3555 adult female 30day    4152 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030584    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030584 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult hindgut, adult Malpighian tubules, adult heart, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030584 expression level Tissue   Expression Level Larval Central Nervous System    338.525 Larval Midgut    265.3 Larval Hindgut    509.2 Larval Malpighian Tubules    434.8 Larval Fat Body    298.3 Larval Salivary Gland    235.2 Larval Trachea    478.175 Larval Carcass    467 Adult Head    507.5 Adult Eye    633.3 Adult Brain    655.2 Adult Thoracic-Abdominal Ganglion    571.4 Adult Crop    463.1 Adult Midgut    419.3 Adult Hindgut    854.5 Adult Malpighian Tubules    604.2 Adult Fat Body    486.4 Adult Salivary Gland    375.5 Adult Heart    602.975 Adult VirginFemale Spermatheca    447.9 Adult InseminatedFemale Spermatheca    419.3 Adult Ovary    429.2 Adult Testis    369.5 Adult Male Accessory Gland    168 Adult Carcass    735 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    338.525 Larval Midgut    265.3 Larval Hindgut  509.2 Larval Malpighian Tubules    434.8 Larval Fat Body    298.3 Larval Salivary Gland    235.2 Larval Trachea    478.175 Larval Carcass    467 Adult Head  507.5 Adult Eye  (633.3) Adult Brain  (655.2) Adult Thoracic-Abdominal Ganglion  (571.4) Adult Crop    463.1 Adult Midgut    419.3 Adult Hindgut  (854.5) Adult Malpighian Tubules  (604.2) Adult Fat Body    486.4 Adult Salivary Gland    375.5 Adult Heart  (602.975) Adult VirginFemale Spermatheca    447.9 Adult InseminatedFemale Spermatheca    419.3 Adult Ovary    429.2 Adult Testis    369.5 Adult Male Accessory Gland    168 Adult Carcass  (735) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    338.525 Larval Midgut    265.3 Larval Hindgut    509.2 Larval Malpighian Tubules    434.8 Larval Fat Body    298.3 Larval Salivary Gland    235.2 Larval Trachea    478.175 Larval Carcass    467 Adult Head    507.5 Adult Eye    633.3 Adult Brain    655.2 Adult Thoracic-Abdominal Ganglion    571.4 Adult Crop    463.1 Adult Midgut    419.3 Adult Hindgut    854.5 Adult Malpighian Tubules    604.2 Adult Fat Body    486.4 Adult Salivary Gland    375.5 Adult Heart    602.975 Adult VirginFemale Spermatheca    447.9 Adult InseminatedFemale Spermatheca    419.3 Adult Ovary    429.2 Adult Testis    369.5 Adult Male Accessory Gland    168 Adult Carcass    735 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    338.525 Larval Midgut    265.3 Larval Hindgut    509.2 Larval Malpighian Tubules    434.8 Larval Fat Body    298.3 Larval Salivary Gland    235.2 Larval Trachea    478.175 Larval Carcass    467 Adult Head    507.5 Adult Eye    633.3 Adult Brain    655.2 Adult Thoracic-Abdominal Ganglion    571.4 Adult Crop    463.1 Adult Midgut    419.3 Adult Hindgut    854.5 Adult Malpighian Tubules    604.2 Adult Fat Body    486.4 Adult Salivary Gland    375.5 Adult Heart    602.975 Adult VirginFemale Spermatheca    447.9 Adult InseminatedFemale Spermatheca    419.3 Adult Ovary    429.2 Adult Testis    369.5 Adult Male Accessory Gland    168 Adult Carcass    735 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030584 expression level Tissue   Expression Level Larval Central Nervous System    338.525 Larval Midgut    265.3 Larval Hindgut    509.2 Larval Malpighian Tubules    434.8 Larval Fat Body    298.3 Larval Salivary Gland    235.2 Larval Trachea    478.175 Larval Carcass    467 Adult Head    507.5 Adult Eye    633.3 Adult Brain    655.2 Adult Thoracic-Abdominal Ganglion    571.4 Adult Crop    463.1 Adult Midgut    419.3 Adult Hindgut    854.5 Adult Malpighian Tubules    604.2 Adult Fat Body    486.4 Adult Salivary Gland    375.5 Adult Heart    602.975 Adult VirginFemale Spermatheca    447.9 Adult InseminatedFemale Spermatheca    419.3 Adult Ovary    429.2 Adult Testis    369.5 Adult Male Accessory Gland    168 Adult Carcass    735 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    338.525 Larval Midgut    265.3 Larval Hindgut  509.2 Larval Malpighian Tubules    434.8 Larval Fat Body    298.3 Larval Salivary Gland    235.2 Larval Trachea    478.175 Larval Carcass    467 Adult Head  507.5 Adult Eye  633.3 Adult Brain  655.2 Adult Thoracic-Abdominal Ganglion  571.4 Adult Crop    463.1 Adult Midgut    419.3 Adult Hindgut  (854.5) Adult Malpighian Tubules  604.2 Adult Fat Body    486.4 Adult Salivary Gland    375.5 Adult Heart  602.975 Adult VirginFemale Spermatheca    447.9 Adult InseminatedFemale Spermatheca    419.3 Adult Ovary    429.2 Adult Testis    369.5 Adult Male Accessory Gland    168 Adult Carcass  735 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    338.525 Larval Midgut    265.3 Larval Hindgut    509.2 Larval Malpighian Tubules    434.8 Larval Fat Body    298.3 Larval Salivary Gland    235.2 Larval Trachea    478.175 Larval Carcass    467 Adult Head    507.5 Adult Eye    633.3 Adult Brain    655.2 Adult Thoracic-Abdominal Ganglion    571.4 Adult Crop    463.1 Adult Midgut    419.3 Adult Hindgut    854.5 Adult Malpighian Tubules    604.2 Adult Fat Body    486.4 Adult Salivary Gland    375.5 Adult Heart    602.975 Adult VirginFemale Spermatheca    447.9 Adult InseminatedFemale Spermatheca    419.3 Adult Ovary    429.2 Adult Testis    369.5 Adult Male Accessory Gland    168 Adult Carcass    735 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    338.525 Larval Midgut    265.3 Larval Hindgut    509.2 Larval Malpighian Tubules    434.8 Larval Fat Body    298.3 Larval Salivary Gland    235.2 Larval Trachea    478.175 Larval Carcass    467 Adult Head    507.5 Adult Eye    633.3 Adult Brain    655.2 Adult Thoracic-Abdominal Ganglion    571.4 Adult Crop    463.1 Adult Midgut    419.3 Adult Hindgut    854.5 Adult Malpighian Tubules    604.2 Adult Fat Body    486.4 Adult Salivary Gland    375.5 Adult Heart    602.975 Adult VirginFemale Spermatheca    447.9 Adult InseminatedFemale Spermatheca    419.3 Adult Ovary    429.2 Adult Testis    369.5 Adult Male Accessory Gland    168 Adult Carcass    735 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    507.5   NA  Eye    633.3   NA  Brain    655.2   338.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    571.4   NA  Crop    463.1   265.3  Midgut    419.3   509.2  Hindgut    854.5   434.8  Malpighian Tubules    604.2   298.3  Fat Body    486.4   235.2  Salivary Gland    375.5   NA  Heart    602.975   478.175  Trachea    NA   NA  VirginFemale Spermatheca    447.9   NA  InseminatedFemale Spermatheca    419.3   NA  Ovary    429.2   NA  Testis    369.5   NA  Male Accessory Gland    168   467  Carcass    735 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030584 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14407-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG14407GD8315 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 CG14407GD8315 Phenotype manifest in Allele tormogen cell, with Scer\GAL4pnr-MD237 CG14407GD8315
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG14407 Class Mutagen Stocks Known lesion CG14407EY04278 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG14407 Class Mutagen Stocks Known lesion CG14407GD8315 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG14407KK108030 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6248 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8315} NA P{KK108030} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}CG32590KG09979 NA insertion of mobile activating element P{EPgy2}CG14407EY04278 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
electron carrier activity inferred from electronic annotation with InterPro:IPR002109 (FlyBase Curators et al., 2004-) protein disulfide oxidoreductase activity inferred from electronic annotation with InterPro:IPR002109 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell redox homeostasis inferred from electronic annotation with InterPro:IPR002109 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG14407 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030584 DroID - A comprehensive database of gene and protein interactions. • FBgn0030584 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32410
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19438 Dere\GG19444 Dgri\GH24287 Dmoj\GI16412 Dper\GL27096 Dpse\GA12959 Dsec\GM12034 Dsim\GD15835 Dvir\GJ17033 Dwil\GK18554 Dyak\GE16098
Curated drosophilid orthologs	Dpse\GA12959
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001109-PA Aedes aegypti (mosquito) AGAP002500-PA Anopheles gambiae (mosquito) XP_625213.1 Apis mellifera (honey bee) XP_001944316.1 Acyrthosiphon pisum (pea aphid) At3g54900.1 Arabidopsis thaliana (wall cress) 13286 Batrachochytrium dendrobatidis (chytrid fungus) 129234 Branchiostoma floridae (lancelet) 269401 Branchiostoma floridae (lancelet) XP_001897119.1 Brugia malayi (roundworm nematode) BGIBMGA008525-PA Bombyx mori (silk worm) ENSBTAP00000017860 Bos taurus (bovine) CAL0004286 Candida albicans (a form of yeast) CN27533 Caenorhabditis brenneri (small nematode) CN29595 Caenorhabditis brenneri (small nematode) CBP02887 Caenorhabditis briggsae (nematode) CE22220 Caenorhabditis elegans (worm) ENSCAFP00000031487 Canis familiaris (dog) CAGL0M07271g Candida glabrata (haploid yeast) Chro.60457 Cryptosporidium hominis (obligate parasite) ENSCINP00000024797 Ciona intestinalis (sea squirt) JA04270 Caenorhabditis japonica (nematode) cn02103 Cryptococcus neoformans (yeast-like fungus) cgd6_3970 Cryptosporidium parvum (protozoan parasite) ENSCPOP00000000798 Cavia porcellus (guinea pig) 194929 Chlamidomonas reinhardtii (green alga) RP03106 Caenorhabditis remanei (nematode) ENSCSAVP00000003551 Ciona savignyi (sedentary tunicate) 163758 Capitella spl (polychaete worm) DDB0233688 Dictyostelium discoideum (amoeba) DEHA2F25476g Debaryomyces Hansenii (yeast) 302234 Daphnia pulex (daphnia) ENSDARP00000064111 Danio rerio (zebra fish) ENSECAP00000017419 Equus caballus (horse) NP_416171.1 Escherichia coli K12 (bacteria) ENSGACP00000006496 Gymnopilus aculeatus (mushroom) ENSGALP00000018029 Gallus gallus (chicken) 88795 Hypsipyla robusta (cedar shoot borer) ENSP00000328570 Homo sapiens (human) ISCW013876-PA Ixodes scapularis (deer tick) KLLA0B09636g Kluyveromyces lactis (yeast) 201172 Lottia gigantea (owl limpet) LmjF01.0110 Leishmania major (virus) 22253 Monocosta brevicollis (choanoflagellate) ENSMODP00000015835 Monodelphis domestica (gray opossum) ENSMMUP00000022473 Macaca mulatta (rhesus monkey) ENSMUSP00000021522 Mus musculus (house mouse) 131043 Nematostella vectensis (starlet anemone) 131054 Nematostella vectensis (starlet anemone) 131070 Nematostella vectensis (starlet anemone) XP_001605234.1 Nasonia vitripennis (wasp) ENSORLP00000019913 Oryzias latipes (japanese killifish) LOC_Os03g63420.1 Oryza sativa (asian rice) 6623 Ostreococcus tauri (green alga) PFC0205c Plasmodium falciparum (protozoal parasite) PHUM001735-PA Pediculus humanus (human body louse) PP12642 Pristionchus pacificus (nematode) 153882 Physcomitrella patens (moss) ENSPPYP00000006952 Pongo pygmaeus (orangutan) 49838 Phytophthora ramorum (sudden oak death pathogen) 127728 Phytophthora sojae (root rot pathogen) 246206 Populus trichocarpa (black cottonwood) 712482 Populus trichocarpa (black cottonwood) ENSPTRP00000011409 Pan troglodytes (chimpanzee) PVX_119350 Plasmodium vivax (protozoal parasite) ENSRNOP00000005781 Rattus norvegicus (norway rat) 5047691 Sorghum bicolor (sorghum) YPL059W Saccharomyces cerevisiae (budding yeast) SPAPB2B4.02 Schizosaccharomyces pombe (fission yeast) XP_001175685.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001175826.1 Strongylocentrotus purpuratus (purple sea urchin) 17368 Trichoplax adhaerens (metazoa) XP_975383.2 Tribolium castaneum (red flour beetle) Tc00.1047053506893.80 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508501.230 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000012597 Tetraodon nigroviridis (green spotted pufferfish) TP02_0196 Theileria parva (parasitic protozoan) 19158 Thalassiosira pseudonana (marine diatom) 37934 Thalassiosira pseudonana (marine diatom) ENSTRUP00000014487 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000054920 Xenopus tropicalis (frog) YALI0F21219g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12114 NV12705 LH20910 ISCW013876 FBgn0233646 FBgn0220552 FBgn0204210 FBgn0187493 FBgn0166975 JGI_V11_302234 FBgn0072997 FBgn0164677 FBgn0139160 FBgn0131743 FBgn0111647 FBgn0096447 BGIBMGA008525 ACYPI007094 GB18700 AGAP002500 AAEL001109 PHUM603470 GLEAN_08371
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	15734 y1 w67c23 P{EPgy2}CG14407EY04278
VDRC	v100710 P{KK108030}VIE-260B v43020 w1118; P{GD8315}v43020 v43021 w1118; P{GD8315}v43021
Genomic Clones ( 1 )
	BACR30H22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 48 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH03087
Other clones	DPiM_RH03087
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07416 AT15585 RE45362 RH02361 RH18670 RH18684 RH18712 RH18715 RH18812 RH19742 RH19792 RH20839 RH44439 RH46554 RH48631 RH51580 RH51653 RH55650 RH56574 SD27807
Other clones	57221 77245 108258 167086 214353.12 EK177624 EK244861 EK272125 EP04015 FGH112A06 FGH118B04 RH48979 RM04289 RM04389 RM04589 RM04689 RM04789 RM04889 RM04989 RP001032922 RP001033272 RP001033478 RP001042444 RP001043020 RP001048871 RP001054468
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030584 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32410
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG14407 BcDNA:RH03087 (FlyBase, 1996-)
Additional comments	Source for merge of CG14407 BcDNA:RH03087 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132746 RefSeq (Proteins) • NP_572974 DDBJ / EMBL / GenBank • AAF48392 AAL89930 AY084192 BI589625 Entrez Gene - A searchable database of RefSeq genes. • 32410 UniProtKB/TrEMBL • Q8SXQ5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glutaredoxin (IPR002109) Monothiol glutaredoxin-related (IPR004480) Thioredoxin-like fold (IPR012336)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030584 DroID - A comprehensive database of gene and protein interactions. • FBgn0030584 DRSC - Results from RNAi screens. • FBgn0030584 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030584 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14407-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030584 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32410 InParanoid A subset of ortholog calls from InParanoid. • AAEL001109-PA Aedes aegypti (mosquito) AGAP002500-PA Anopheles gambiae (mosquito) XP_625213.1 Apis mellifera (honey bee) XP_001944316.1 Acyrthosiphon pisum (pea aphid) At3g54900.1 Arabidopsis thaliana (wall cress) 13286 Batrachochytrium dendrobatidis (chytrid fungus) 129234 Branchiostoma floridae (lancelet) 269401 Branchiostoma floridae (lancelet) XP_001897119.1 Brugia malayi (roundworm nematode) BGIBMGA008525-PA Bombyx mori (silk worm) ENSBTAP00000017860 Bos taurus (bovine) CAL0004286 Candida albicans (a form of yeast) CN27533 Caenorhabditis brenneri (small nematode) CN29595 Caenorhabditis brenneri (small nematode) CBP02887 Caenorhabditis briggsae (nematode) CE22220 Caenorhabditis elegans (worm) ENSCAFP00000031487 Canis familiaris (dog) CAGL0M07271g Candida glabrata (haploid yeast) Chro.60457 Cryptosporidium hominis (obligate parasite) ENSCINP00000024797 Ciona intestinalis (sea squirt) JA04270 Caenorhabditis japonica (nematode) cn02103 Cryptococcus neoformans (yeast-like fungus) cgd6_3970 Cryptosporidium parvum (protozoan parasite) ENSCPOP00000000798 Cavia porcellus (guinea pig) 194929 Chlamidomonas reinhardtii (green alga) RP03106 Caenorhabditis remanei (nematode) ENSCSAVP00000003551 Ciona savignyi (sedentary tunicate) 163758 Capitella spl (polychaete worm) DDB0233688 Dictyostelium discoideum (amoeba) DEHA2F25476g Debaryomyces Hansenii (yeast) 302234 Daphnia pulex (daphnia) ENSDARP00000064111 Danio rerio (zebra fish) ENSECAP00000017419 Equus caballus (horse) NP_416171.1 Escherichia coli K12 (bacteria) ENSGACP00000006496 Gymnopilus aculeatus (mushroom) ENSGALP00000018029 Gallus gallus (chicken) 88795 Hypsipyla robusta (cedar shoot borer) ENSP00000328570 Homo sapiens (human) ISCW013876-PA Ixodes scapularis (deer tick) KLLA0B09636g Kluyveromyces lactis (yeast) 201172 Lottia gigantea (owl limpet) LmjF01.0110 Leishmania major (virus) 22253 Monocosta brevicollis (choanoflagellate) ENSMODP00000015835 Monodelphis domestica (gray opossum) ENSMMUP00000022473 Macaca mulatta (rhesus monkey) ENSMUSP00000021522 Mus musculus (house mouse) 131043 Nematostella vectensis (starlet anemone) 131054 Nematostella vectensis (starlet anemone) 131070 Nematostella vectensis (starlet anemone) XP_001605234.1 Nasonia vitripennis (wasp) ENSORLP00000019913 Oryzias latipes (japanese killifish) LOC_Os03g63420.1 Oryza sativa (asian rice) 6623 Ostreococcus tauri (green alga) PFC0205c Plasmodium falciparum (protozoal parasite) PHUM001735-PA Pediculus humanus (human body louse) PP12642 Pristionchus pacificus (nematode) 153882 Physcomitrella patens (moss) ENSPPYP00000006952 Pongo pygmaeus (orangutan) 49838 Phytophthora ramorum (sudden oak death pathogen) 127728 Phytophthora sojae (root rot pathogen) 246206 Populus trichocarpa (black cottonwood) 712482 Populus trichocarpa (black cottonwood) ENSPTRP00000011409 Pan troglodytes (chimpanzee) PVX_119350 Plasmodium vivax (protozoal parasite) ENSRNOP00000005781 Rattus norvegicus (norway rat) 5047691 Sorghum bicolor (sorghum) YPL059W Saccharomyces cerevisiae (budding yeast) SPAPB2B4.02 Schizosaccharomyces pombe (fission yeast) XP_001175685.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001175826.1 Strongylocentrotus purpuratus (purple sea urchin) 17368 Trichoplax adhaerens (metazoa) XP_975383.2 Tribolium castaneum (red flour beetle) Tc00.1047053506893.80 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508501.230 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000012597 Tetraodon nigroviridis (green spotted pufferfish) TP02_0196 Theileria parva (parasitic protozoan) 19158 Thalassiosira pseudonana (marine diatom) 37934 Thalassiosira pseudonana (marine diatom) ENSTRUP00000014487 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000054920 Xenopus tropicalis (frog) YALI0F21219g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32410 modMine - Data generated by the modENCODE project. • FBgn0030584 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12114 NV12705 LH20910 ISCW013876 FBgn0233646 FBgn0220552 FBgn0204210 FBgn0187493 FBgn0166975 JGI_V11_302234 FBgn0072997 FBgn0164677 FBgn0139160 FBgn0131743 FBgn0111647 FBgn0096447 BGIBMGA008525 ACYPI007094 GB18700 AGAP002500 AAEL001109 PHUM603470 GLEAN_08371
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	BcDNA:RH03087   CG14407 (Iida et al., 2007, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
	FBgn0063666
References ( 10 )
Research paper	Iida et al., 2007, BMC Evol. Biol. 7: 75 Expansion and evolution of insect GMC oxidoreductases. [FBrf0202218]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]