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Gene Dmel\Lsd-2

General Information
Symbol	Dmel\Lsd-2	Species	D. melanogaster
Name	Lipid storage droplet-2	Annotation symbol	CG9057
Feature type	protein_coding_gene	FlyBase ID	FBgn0030608
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	LSD2, plin2
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	13A8-13A9	Sequence location	X:14,965,496..14,970,253 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Lipid storage droplet-2 is referred to in FlyBase by the symbol Dmel\Lsd-2 (CG9057, FBgn0030608). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: lipid metabolic process; lipid particle transport along microtubule; regulation of transport; sequestering of triglyceride; imaginal disc-derived wing morphogenesis; lipid storage. 28 alleles are reported. The phenotypes of these alleles are annotated with: fat body; lipid particle; mesothoracic tergum; nurse cell. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Perilipin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult female reproductive system, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval hindgut, larval trachea, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1637359_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Lsd-2. Gene sequence location is X:14965496..14970253.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms negative regulation of lipid catabolic process
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 13A8-13A9   Limits computationally determined from genome sequence between P{EP}hiwEP1308 and P{EP}Ahcy13EP1007
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Lsd-2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Multiphase exon postulated: exon reading frame differs in alternative transcripts. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Lsd-2-RA FBtr0073967  NM_132768   2148   352 Lsd-2-RB FBtr0110968  NM_001042811   2097   335 Lsd-2-RD FBtr0340427     2279   318 Lsd-2-RE FBtr0340428     2330   335
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Lsd-2-PA   FBpp0073784   38.2   352   8.72     NP_572996   AAF48419 Lsd-2-PB   FBpp0110268   36.4   335   9.20     NP_001036276   ABI30981 Lsd-2-PD   FBpp0309373   35.6   318   6.17       Lsd-2-PE   FBpp0309374   37.4   335   5.54
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Perilipin (IPR004279)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201756   AA246571   AA263506   AA390765   AA391672   AA392621   AA567378   AA699107   AA801704   AA817287   AA820420   AA948794   AA949660   AA951808   AA978652   AA979431   AE014298 AAF48419   AE014298 ABI30981   AI063575   AI106959   AI108701   AI109020   AI134456   AI135469   AI135780   AI135787   AI386829   AI387748   AI402042   AI402409   AI404242   AI406145   AI455022   AI512444   AI513349   AI513816   AI516451   AI517172   AI517234   AI519933   AY060242 AAL25281   BG638388   BG638723   BG638971   BH609997   BI163379   BI163649   BI164522   BI165196   BI167194   BI167268   BI213325   BI215457   BI215553   BI229442   BI234194   BI236076   BI239794   BI240688   BI240730   BI243379   BI365557   BI370140   BI370159   BI371120   BI371912   BI372611   BI373099   BI376055   BI484251   BI484752   BI484819   BI484872   BI486261   BI565681   BI581356   BI582078   BI582324   BI592079   BI608423   BI611830   BI619167   BP549357   BP549358   BQ103727   CA806609   CK662059   CO183486   CO186513   CO187138   CO188497   CO189211   CO189819   CO192976   CO196285   CO262211   CO262355   CO263687   CO265809   CO267651   CO270824   CO273282   CO274032   CO274441   CO278447   CO278726   CO280663   CO280994   CO281311   CO284367   CO287804   CO289181   CO290561   CO290587   CO290953   CO290955   CO292137   CO294446   CO294477   CO295370   CO298081   CO298994   CO304308   CO309211   CO310033   CO310669   CO310958   CO311763   CO314660   CO314929   CO315026   CO316311   CO320797   CO322279   CO323201   CO323203   CO324319   CO324471   CO325056   CO327309   CO327741   CO329072   CO330288   CO332218   CO332710   CO332718   CO333518   CO339150   CZ472091   CZ481102   CZ483844   CZ483845   EC052621   EC057886   EC058745   EC059064   EC059325   EC061603   EC061651   EC062183   EC064110   EC064933   EC065541   EC067282   EC067788   EC067962   EC069424   EC072956   EC075316   EC075645   EC076329   EC077791   EC079291   EC080372   EC080400   EC080469   EC082204   EC083850   EC084117   EC084805   EC086023   EC086275   EC086367   EC196448   EC196489   EC196611   EC197036   EC197366   EC200705   EC200708   EC200824   EC202933   EC204153   EC206273   EC208991   EC209327   EC209457   EC209740   EC209941   EC212611   EC213976   EC219277   EC220500   EC220896   EC222011   EC222121   EC225030   EC225531   EC226835   EC228314   EC229308   EC229458   EC229631   EC229705   EC236616   EC236664   EC240134   EC240250   EC241962   EC242252   EC242890   EC244705   EC245178   EC246988   EC251170   EC251694   EC252598   EC252798   EC254560   EC255706   EV578399   EV578811   EV581378   EV582901   EV583377   EV584608   EV585195   EV586427   EV587320   EV590487   EV590873   EV595948   EV596856   EV599425   GH923434   GR705698
UniProtKB/Swiss-Prot	Q9VXY7
UniProtKB/TrEMBL	Q0KHS6 Q0KHS7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   fat body & midgut | anterior   (Gronke et al., 2003) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4   organism | ubiquitous   (Gronke et al., 2003) embryonic stage 4 -- 6   organism   (Fisher et al., 2012) Comment:rapidly degraded organism | faint & ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) pole plasm   (Fisher et al., 2012) embryonic stage 5   germline cell   (Gronke et al., 2003) embryonic stage 5 -- 11   germline cell   (Gronke et al., 2003) embryonic stage 7 -- 8   pole cell   (Fisher et al., 2012) embryonic stage 9 -- 10   germline cell   (Fisher et al., 2012) embryonic stage 11 -- 12   fat body/gonad primordium   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 12 -- 17   embryonic/larval fat body   (Gronke et al., 2003) embryonic/larval midgut primordium   (Gronke et al., 2003) embryonic stage 13   amnioserosa   (Gronke et al., 2003) embryonic stage 13 -- 16   embryonic/larval fat body   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) third instar larval stage   fat body   (Gronke et al., 2003) wandering third instar larval stage   wing disc | restricted   (Fauny et al., 2005) wing pouch | restricted   (Fauny et al., 2005) anterior-posterior boundary of the wing disc of wing pouch   (Fauny et al., 2005) mesothoracic tergum primordium   (Fauny et al., 2005) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism   (Gronke et al., 2003)
Additional Descriptive Data
	Lsd-2 transcript is expressed in the wing pouch of wandering third instar larvae; expression is more pronounced in a strong band with a weaker juxtaposed band along the anterior-posterior compartment boundary, and excluded from the dorsal-ventral compartment boundary. Lsd-2 transcript is also expressed in the presumptive notum. (Fauny et al., 2005) Northern analysis demonstrates that Lsd-2 transcript levels are highest in early embryos (0-3 hours AEL), third instar larvae, and adults. (Gronke et al., 2003) Maternally contributed Lsd-2 transcript is detected ubiquitously in pre-cellular blastoderm embryos. In cellular blastoderm the transcript is only detected in germ cells. During germ band contraction expression is detected in the amnioserosa and anterior of the midgut as well as the fat body. During third instar Lsd-2 is detected exclusively in the fat body. (Gronke et al., 2003)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter or direct label Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   fat body   • lipid particle (Gronke et al., 2003) immunolocalization Stage Tissue/Position (including subcellular localization) Reference wandering third instar larval stage   wing disc | restricted   (Fauny et al., 2005) wing pouch | restricted   (Fauny et al., 2005) anterior-posterior boundary of the wing disc of wing pouch   (Fauny et al., 2005) mesothoracic tergum primordium   (Fauny et al., 2005) imaginal disc epithelial cell of wing disc   (Fauny et al., 2005) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	Lsd-2 protein is expressed in the wing pouch of wandering third instar larvae; expression is excluded from the dorsal-ventral compartment boundary. Lsd-2 protein is also expressed in the presumptive notum. Lsd-2 protein is restricted to the epithelial cell layer of the wing disc, and does not colocalize with adepithelial-expressed twi protein. (Fauny et al., 2005) A GFP-Lsd-2 fusion protein was used to determine that Lsd-2 protein was associated with fat droplets and vesicles in the third instar larval fat body. (Gronke et al., 2003)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006, Teixeira et al., 2003, Welte et al., 2005, Cermelli et al., 2006, Bi et al., 2012) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult female reproductive system, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval hindgut, larval trachea, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    346.65 Larval Midgut    1181.7 Larval Hindgut    374 Larval Malpighian Tubules    1167.1 Larval Fat Body    1336.5 Larval Salivary Gland    980.6 Larval Trachea    289.05 Larval Carcass    198.2 Adult Head    844.4 Adult Eye    834.95 Adult Brain    315.5 Adult Thoracic-Abdominal Ganglion    439.4 Adult Crop    1406 Adult Midgut    1335.3 Adult Hindgut    1014.5 Adult Malpighian Tubules    1011.6 Adult Fat Body    3154.5 Adult Salivary Gland    671.6 Adult Heart    2112.175 Adult VirginFemale Spermatheca    1210.2 Adult InseminatedFemale Spermatheca    1454.8 Adult Ovary    1481.8 Adult Testis    49.6 Adult Male Accessory Gland    372.9 Adult Carcass    2086.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    346.65 Larval Midgut  (1181.7) Larval Hindgut    374 Larval Malpighian Tubules  (1167.1) Larval Fat Body  (1336.5) Larval Salivary Gland  (980.6) Larval Trachea    289.05 Larval Carcass    198.2 Adult Head  (844.4) Adult Eye  (834.95) Adult Brain    315.5 Adult Thoracic-Abdominal Ganglion    439.4 Adult Crop  (1406) Adult Midgut  (1335.3) Adult Hindgut  (1014.5) Adult Malpighian Tubules  (1011.6) Adult Fat Body  (3154.5) Adult Salivary Gland  (671.6) Adult Heart  (2112.175) Adult VirginFemale Spermatheca  (1210.2) Adult InseminatedFemale Spermatheca  (1454.8) Adult Ovary  (1481.8) Adult Testis    49.6 Adult Male Accessory Gland    372.9 Adult Carcass  (2086.6) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    346.65 Larval Midgut  (1181.7) Larval Hindgut    374 Larval Malpighian Tubules  (1167.1) Larval Fat Body  (1336.5) Larval Salivary Gland    980.6 Larval Trachea    289.05 Larval Carcass    198.2 Adult Head    844.4 Adult Eye    834.95 Adult Brain    315.5 Adult Thoracic-Abdominal Ganglion    439.4 Adult Crop  (1406) Adult Midgut  (1335.3) Adult Hindgut  1014.5 Adult Malpighian Tubules  1011.6 Adult Fat Body  (3154.5) Adult Salivary Gland    671.6 Adult Heart  (2112.175) Adult VirginFemale Spermatheca  (1210.2) Adult InseminatedFemale Spermatheca  (1454.8) Adult Ovary  (1481.8) Adult Testis    49.6 Adult Male Accessory Gland    372.9 Adult Carcass  (2086.6) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    346.65 Larval Midgut    1181.7 Larval Hindgut    374 Larval Malpighian Tubules    1167.1 Larval Fat Body    1336.5 Larval Salivary Gland    980.6 Larval Trachea    289.05 Larval Carcass    198.2 Adult Head    844.4 Adult Eye    834.95 Adult Brain    315.5 Adult Thoracic-Abdominal Ganglion    439.4 Adult Crop    1406 Adult Midgut    1335.3 Adult Hindgut    1014.5 Adult Malpighian Tubules    1011.6 Adult Fat Body    3154.5 Adult Salivary Gland    671.6 Adult Heart    2112.175 Adult VirginFemale Spermatheca    1210.2 Adult InseminatedFemale Spermatheca    1454.8 Adult Ovary    1481.8 Adult Testis    49.6 Adult Male Accessory Gland    372.9 Adult Carcass    2086.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    346.65 Larval Midgut    1181.7 Larval Hindgut    374 Larval Malpighian Tubules    1167.1 Larval Fat Body    1336.5 Larval Salivary Gland    980.6 Larval Trachea    289.05 Larval Carcass    198.2 Adult Head    844.4 Adult Eye    834.95 Adult Brain    315.5 Adult Thoracic-Abdominal Ganglion    439.4 Adult Crop    1406 Adult Midgut    1335.3 Adult Hindgut    1014.5 Adult Malpighian Tubules    1011.6 Adult Fat Body    3154.5 Adult Salivary Gland    671.6 Adult Heart    2112.175 Adult VirginFemale Spermatheca    1210.2 Adult InseminatedFemale Spermatheca    1454.8 Adult Ovary    1481.8 Adult Testis    49.6 Adult Male Accessory Gland    372.9 Adult Carcass    2086.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    346.65 Larval Midgut  (1181.7) Larval Hindgut    374 Larval Malpighian Tubules  (1167.1) Larval Fat Body  (1336.5) Larval Salivary Gland  (980.6) Larval Trachea    289.05 Larval Carcass    198.2 Adult Head  (844.4) Adult Eye  (834.95) Adult Brain    315.5 Adult Thoracic-Abdominal Ganglion    439.4 Adult Crop  (1406) Adult Midgut  (1335.3) Adult Hindgut  (1014.5) Adult Malpighian Tubules  (1011.6) Adult Fat Body  (3154.5) Adult Salivary Gland  671.6 Adult Heart  (2112.175) Adult VirginFemale Spermatheca  (1210.2) Adult InseminatedFemale Spermatheca  (1454.8) Adult Ovary  (1481.8) Adult Testis    49.6 Adult Male Accessory Gland    372.9 Adult Carcass  (2086.6) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    346.65 Larval Midgut  1181.7 Larval Hindgut    374 Larval Malpighian Tubules  1167.1 Larval Fat Body  1336.5 Larval Salivary Gland    980.6 Larval Trachea    289.05 Larval Carcass    198.2 Adult Head    844.4 Adult Eye    834.95 Adult Brain    315.5 Adult Thoracic-Abdominal Ganglion    439.4 Adult Crop  1406 Adult Midgut  1335.3 Adult Hindgut  1014.5 Adult Malpighian Tubules  1011.6 Adult Fat Body  (3154.5) Adult Salivary Gland    671.6 Adult Heart  (2112.175) Adult VirginFemale Spermatheca  1210.2 Adult InseminatedFemale Spermatheca  1454.8 Adult Ovary  1481.8 Adult Testis    49.6 Adult Male Accessory Gland    372.9 Adult Carcass  (2086.6) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    346.65 Larval Midgut    1181.7 Larval Hindgut    374 Larval Malpighian Tubules    1167.1 Larval Fat Body    1336.5 Larval Salivary Gland    980.6 Larval Trachea    289.05 Larval Carcass    198.2 Adult Head    844.4 Adult Eye    834.95 Adult Brain    315.5 Adult Thoracic-Abdominal Ganglion    439.4 Adult Crop    1406 Adult Midgut    1335.3 Adult Hindgut    1014.5 Adult Malpighian Tubules    1011.6 Adult Fat Body    3154.5 Adult Salivary Gland    671.6 Adult Heart    2112.175 Adult VirginFemale Spermatheca    1210.2 Adult InseminatedFemale Spermatheca    1454.8 Adult Ovary    1481.8 Adult Testis    49.6 Adult Male Accessory Gland    372.9 Adult Carcass    2086.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    844.4   NA  Eye    834.95   NA  Brain    315.5   346.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    439.4   NA  Crop    1406   1181.7  Midgut    1335.3   374  Hindgut    1014.5   1167.1  Malpighian Tubules    1011.6   1336.5  Fat Body    3154.5   980.6  Salivary Gland    671.6   NA  Heart    2112.175   289.05  Trachea    NA   NA  VirginFemale Spermatheca    1210.2   NA  InseminatedFemale Spermatheca    1454.8   NA  Ovary    1481.8   NA  Testis    49.6   NA  Male Accessory Gland    372.9   198.2  Carcass    2086.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    82 central nervous system, larvae L3    69 central nervous system, pupae P8    63 head, virgin 1-day female    99 head, virgin 4-day female    131 head, virgin 20-day female    96 head, mated 1-day female    155 head, mated 4-day female    246 head, mated 20-day female    103 head, mated 1-day male    151 head, mated 4-day male    167 head, mated 20-day male    166 salivary gland, larvae L3 wandering    26 salivary gland, white prepupae    67 digestive system, larvae L3 wandering    146 digestive system, 1-day adult    153 digestive system, 4-day adult    264 digestive system, 20-day adult    145 fat body, larvae L3 wandering    472 fat body, white prepupae    171 fat body, pupae P8    113 carcass, larvae L3 wandering    61 carcass, 1-day adult    147 carcass, 4-day adult    186 carcass, 20-day adult    177 ovary, virgin 4-day female    334 ovary, mated 4-day female    470 testis, mated 4-day male    13 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (82) central nervous system, larvae L3  (69) central nervous system, pupae P8  (63) head, virgin 1-day female  (99) head, virgin 4-day female  (131) head, virgin 20-day female  (96) head, mated 1-day female  (155) head, mated 4-day female  (246) head, mated 20-day female  (103) head, mated 1-day male  (151) head, mated 4-day male  (167) head, mated 20-day male  (166) salivary gland, larvae L3 wandering  26 salivary gland, white prepupae  (67) digestive system, larvae L3 wandering  (146) digestive system, 1-day adult  (153) digestive system, 4-day adult  (264) digestive system, 20-day adult  (145) fat body, larvae L3 wandering  (472) fat body, white prepupae  (171) fat body, pupae P8  (113) carcass, larvae L3 wandering  (61) carcass, 1-day adult  (147) carcass, 4-day adult  (186) carcass, 20-day adult  (177) ovary, virgin 4-day female  (334) ovary, mated 4-day female  (470) testis, mated 4-day male    13 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    82 central nervous system, larvae L3    69 central nervous system, pupae P8    63 head, virgin 1-day female    99 head, virgin 4-day female  (131) head, virgin 20-day female    96 head, mated 1-day female  (155) head, mated 4-day female  (246) head, mated 20-day female  103 head, mated 1-day male  (151) head, mated 4-day male  (167) head, mated 20-day male  (166) salivary gland, larvae L3 wandering    26 salivary gland, white prepupae    67 digestive system, larvae L3 wandering  (146) digestive system, 1-day adult  (153) digestive system, 4-day adult  (264) digestive system, 20-day adult  (145) fat body, larvae L3 wandering  (472) fat body, white prepupae  (171) fat body, pupae P8  (113) carcass, larvae L3 wandering    61 carcass, 1-day adult  (147) carcass, 4-day adult  (186) carcass, 20-day adult  (177) ovary, virgin 4-day female  (334) ovary, mated 4-day female  (470) testis, mated 4-day male    13 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    82 central nervous system, larvae L3    69 central nervous system, pupae P8    63 head, virgin 1-day female    99 head, virgin 4-day female    131 head, virgin 20-day female    96 head, mated 1-day female    155 head, mated 4-day female    246 head, mated 20-day female    103 head, mated 1-day male    151 head, mated 4-day male    167 head, mated 20-day male    166 salivary gland, larvae L3 wandering    26 salivary gland, white prepupae    67 digestive system, larvae L3 wandering    146 digestive system, 1-day adult    153 digestive system, 4-day adult    264 digestive system, 20-day adult    145 fat body, larvae L3 wandering    472 fat body, white prepupae    171 fat body, pupae P8    113 carcass, larvae L3 wandering    61 carcass, 1-day adult    147 carcass, 4-day adult    186 carcass, 20-day adult    177 ovary, virgin 4-day female    334 ovary, mated 4-day female    470 testis, mated 4-day male    13 accessory gland, mated 4-day male    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    82 central nervous system, larvae L3    69 central nervous system, pupae P8    63 head, virgin 1-day female    99 head, virgin 4-day female    131 head, virgin 20-day female    96 head, mated 1-day female    155 head, mated 4-day female    246 head, mated 20-day female    103 head, mated 1-day male    151 head, mated 4-day male    167 head, mated 20-day male    166 salivary gland, larvae L3 wandering    26 salivary gland, white prepupae    67 digestive system, larvae L3 wandering    146 digestive system, 1-day adult    153 digestive system, 4-day adult    264 digestive system, 20-day adult    145 fat body, larvae L3 wandering    472 fat body, white prepupae    171 fat body, pupae P8    113 carcass, larvae L3 wandering    61 carcass, 1-day adult    147 carcass, 4-day adult    186 carcass, 20-day adult    177 ovary, virgin 4-day female    334 ovary, mated 4-day female    470 testis, mated 4-day male    13 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (82) central nervous system, larvae L3  (69) central nervous system, pupae P8  (63) head, virgin 1-day female  (99) head, virgin 4-day female  (131) head, virgin 20-day female  (96) head, mated 1-day female  (155) head, mated 4-day female  (246) head, mated 20-day female  (103) head, mated 1-day male  (151) head, mated 4-day male  (167) head, mated 20-day male  (166) salivary gland, larvae L3 wandering  26 salivary gland, white prepupae  (67) digestive system, larvae L3 wandering  (146) digestive system, 1-day adult  (153) digestive system, 4-day adult  (264) digestive system, 20-day adult  (145) fat body, larvae L3 wandering  (472) fat body, white prepupae  (171) fat body, pupae P8  (113) carcass, larvae L3 wandering  (61) carcass, 1-day adult  (147) carcass, 4-day adult  (186) carcass, 20-day adult  (177) ovary, virgin 4-day female  (334) ovary, mated 4-day female  (470) testis, mated 4-day male    13 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    82 central nervous system, larvae L3    69 central nervous system, pupae P8    63 head, virgin 1-day female    99 head, virgin 4-day female  131 head, virgin 20-day female    96 head, mated 1-day female  (155) head, mated 4-day female  (246) head, mated 20-day female  103 head, mated 1-day male  (151) head, mated 4-day male  (167) head, mated 20-day male  (166) salivary gland, larvae L3 wandering    26 salivary gland, white prepupae    67 digestive system, larvae L3 wandering  (146) digestive system, 1-day adult  (153) digestive system, 4-day adult  (264) digestive system, 20-day adult  (145) fat body, larvae L3 wandering  (472) fat body, white prepupae  (171) fat body, pupae P8  113 carcass, larvae L3 wandering    61 carcass, 1-day adult  (147) carcass, 4-day adult  (186) carcass, 20-day adult  (177) ovary, virgin 4-day female  (334) ovary, mated 4-day female  (470) testis, mated 4-day male    13 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    82 central nervous system, larvae L3    69 central nervous system, pupae P8    63 head, virgin 1-day female    99 head, virgin 4-day female    131 head, virgin 20-day female    96 head, mated 1-day female    155 head, mated 4-day female    246 head, mated 20-day female    103 head, mated 1-day male    151 head, mated 4-day male    167 head, mated 20-day male    166 salivary gland, larvae L3 wandering    26 salivary gland, white prepupae    67 digestive system, larvae L3 wandering    146 digestive system, 1-day adult    153 digestive system, 4-day adult    264 digestive system, 20-day adult    145 fat body, larvae L3 wandering    472 fat body, white prepupae    171 fat body, pupae P8    113 carcass, larvae L3 wandering    61 carcass, 1-day adult    147 carcass, 4-day adult    186 carcass, 20-day adult    177 ovary, virgin 4-day female    334 ovary, mated 4-day female    470 testis, mated 4-day male    13 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    456 embryo 02-04hr    71 embryo 04-06hr    10 embryo 06-08hr    27 embryo 08-10hr    47 embryo 10-12hr    65 embryo 12-14hr    79 embryo 14-16hr    83 embryo 16-18hr    78 embryo 18-20hr    76 embryo 20-22hr    73 embryo 22-24hr    96 larva L1    51 larva L2    53 larva L3 12hr old    65 larva L3 puffstage 1-2    119 larva L3 puffstage 3-6    134 larva L3 puffstage 7-9    125 white prepupae new    113 white prepupae 12hr    132 white prepupae 24hr    109 pupae 2d postWPP    82 pupae 3d postWPP    53 pupae 4d postWPP    55 adult male 01day    91 adult male 05day    101 adult male 30day    101 adult female 01day    153 adult female 05day    285 adult female 30day    271 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (456) embryo 02-04hr  (71) embryo 04-06hr    10 embryo 06-08hr  (27) embryo 08-10hr  (47) embryo 10-12hr  (65) embryo 12-14hr  (79) embryo 14-16hr  (83) embryo 16-18hr  (78) embryo 18-20hr  (76) embryo 20-22hr  (73) embryo 22-24hr  (96) larva L1  (51) larva L2  (53) larva L3 12hr old  (65) larva L3 puffstage 1-2  (119) larva L3 puffstage 3-6  (134) larva L3 puffstage 7-9  (125) white prepupae new  (113) white prepupae 12hr  (132) white prepupae 24hr  (109) pupae 2d postWPP  (82) pupae 3d postWPP  (53) pupae 4d postWPP  (55) adult male 01day  (91) adult male 05day  (101) adult male 30day  (101) adult female 01day  (153) adult female 05day  (285) adult female 30day  (271) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (456) embryo 02-04hr    71 embryo 04-06hr    10 embryo 06-08hr    27 embryo 08-10hr    47 embryo 10-12hr    65 embryo 12-14hr    79 embryo 14-16hr    83 embryo 16-18hr    78 embryo 18-20hr    76 embryo 20-22hr    73 embryo 22-24hr    96 larva L1    51 larva L2    53 larva L3 12hr old    65 larva L3 puffstage 1-2  (119) larva L3 puffstage 3-6  (134) larva L3 puffstage 7-9  (125) white prepupae new  (113) white prepupae 12hr  (132) white prepupae 24hr  (109) pupae 2d postWPP    82 pupae 3d postWPP    53 pupae 4d postWPP    55 adult male 01day    91 adult male 05day  101 adult male 30day  101 adult female 01day  (153) adult female 05day  (285) adult female 30day  (271) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    456 embryo 02-04hr    71 embryo 04-06hr    10 embryo 06-08hr    27 embryo 08-10hr    47 embryo 10-12hr    65 embryo 12-14hr    79 embryo 14-16hr    83 embryo 16-18hr    78 embryo 18-20hr    76 embryo 20-22hr    73 embryo 22-24hr    96 larva L1    51 larva L2    53 larva L3 12hr old    65 larva L3 puffstage 1-2    119 larva L3 puffstage 3-6    134 larva L3 puffstage 7-9    125 white prepupae new    113 white prepupae 12hr    132 white prepupae 24hr    109 pupae 2d postWPP    82 pupae 3d postWPP    53 pupae 4d postWPP    55 adult male 01day    91 adult male 05day    101 adult male 30day    101 adult female 01day    153 adult female 05day    285 adult female 30day    271 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    456 embryo 02-04hr    71 embryo 04-06hr    10 embryo 06-08hr    27 embryo 08-10hr    47 embryo 10-12hr    65 embryo 12-14hr    79 embryo 14-16hr    83 embryo 16-18hr    78 embryo 18-20hr    76 embryo 20-22hr    73 embryo 22-24hr    96 larva L1    51 larva L2    53 larva L3 12hr old    65 larva L3 puffstage 1-2    119 larva L3 puffstage 3-6    134 larva L3 puffstage 7-9    125 white prepupae new    113 white prepupae 12hr    132 white prepupae 24hr    109 pupae 2d postWPP    82 pupae 3d postWPP    53 pupae 4d postWPP    55 adult male 01day    91 adult male 05day    101 adult male 30day    101 adult female 01day    153 adult female 05day    285 adult female 30day    271 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (456) embryo 02-04hr  (71) embryo 04-06hr    10 embryo 06-08hr  27 embryo 08-10hr  (47) embryo 10-12hr  (65) embryo 12-14hr  (79) embryo 14-16hr  (83) embryo 16-18hr  (78) embryo 18-20hr  (76) embryo 20-22hr  (73) embryo 22-24hr  (96) larva L1  (51) larva L2  (53) larva L3 12hr old  (65) larva L3 puffstage 1-2  (119) larva L3 puffstage 3-6  (134) larva L3 puffstage 7-9  (125) white prepupae new  (113) white prepupae 12hr  (132) white prepupae 24hr  (109) pupae 2d postWPP  (82) pupae 3d postWPP  (53) pupae 4d postWPP  (55) adult male 01day  (91) adult male 05day  (101) adult male 30day  (101) adult female 01day  (153) adult female 05day  (285) adult female 30day  (271) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (456) embryo 02-04hr    71 embryo 04-06hr    10 embryo 06-08hr    27 embryo 08-10hr    47 embryo 10-12hr    65 embryo 12-14hr    79 embryo 14-16hr    83 embryo 16-18hr    78 embryo 18-20hr    76 embryo 20-22hr    73 embryo 22-24hr    96 larva L1    51 larva L2    53 larva L3 12hr old    65 larva L3 puffstage 1-2  119 larva L3 puffstage 3-6  134 larva L3 puffstage 7-9  125 white prepupae new  113 white prepupae 12hr  132 white prepupae 24hr  109 pupae 2d postWPP    82 pupae 3d postWPP    53 pupae 4d postWPP    55 adult male 01day    91 adult male 05day  101 adult male 30day  101 adult female 01day  (153) adult female 05day  (285) adult female 30day  (271) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    456 embryo 02-04hr    71 embryo 04-06hr    10 embryo 06-08hr    27 embryo 08-10hr    47 embryo 10-12hr    65 embryo 12-14hr    79 embryo 14-16hr    83 embryo 16-18hr    78 embryo 18-20hr    76 embryo 20-22hr    73 embryo 22-24hr    96 larva L1    51 larva L2    53 larva L3 12hr old    65 larva L3 puffstage 1-2    119 larva L3 puffstage 3-6    134 larva L3 puffstage 7-9    125 white prepupae new    113 white prepupae 12hr    132 white prepupae 24hr    109 pupae 2d postWPP    82 pupae 3d postWPP    53 pupae 4d postWPP    55 adult male 01day    91 adult male 05day    101 adult male 30day    101 adult female 01day    153 adult female 05day    285 adult female 30day    271 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    53 embryonic 1182-4H    41 embryonic GM2    50 embryonic Kc167    138 embryonic S1    88 embryonic S3    88 leg disc CME L1    82 wing disc CME-W2    56 wing disc ML-DmD8    75 wing disc ML-DmD9    115 wing disc ML-DmD16-c3    95 wing disc ML-DmD21    61 wing disc ML-DmD32    111 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    110 tumorous blood cells mbn2    0 ovary fGS/OSS    136 ovary OSC    74 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4  (53) embryonic 1182-4H  (41) embryonic GM2  (50) embryonic Kc167  (138) embryonic S1  (88) embryonic S3  (88) leg disc CME L1  (82) wing disc CME-W2  (56) wing disc ML-DmD8  (75) wing disc ML-DmD9  (115) wing disc ML-DmD16-c3  (95) wing disc ML-DmD21  (61) wing disc ML-DmD32  (111) haltere disc ML-DmD17-c3  (70) eye-antennal disc ML-DmD11  (44) antennal disc ML-DmD20-c5  (48) mixed discs ML-DmD4-c1  (81) CNS ML-DmBG1-c1  (50) CNS ML-DmBG2-c2  (110) tumorous blood cells mbn2    0 ovary fGS/OSS  (136) ovary OSC  (74) ovary OSS  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    53 embryonic 1182-4H    41 embryonic GM2    50 embryonic Kc167  (138) embryonic S1    88 embryonic S3    88 leg disc CME L1    82 wing disc CME-W2    56 wing disc ML-DmD8    75 wing disc ML-DmD9  (115) wing disc ML-DmD16-c3    95 wing disc ML-DmD21    61 wing disc ML-DmD32  (111) haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2  (110) tumorous blood cells mbn2    0 ovary fGS/OSS  (136) ovary OSC    74 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    53 embryonic 1182-4H    41 embryonic GM2    50 embryonic Kc167    138 embryonic S1    88 embryonic S3    88 leg disc CME L1    82 wing disc CME-W2    56 wing disc ML-DmD8    75 wing disc ML-DmD9    115 wing disc ML-DmD16-c3    95 wing disc ML-DmD21    61 wing disc ML-DmD32    111 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    110 tumorous blood cells mbn2    0 ovary fGS/OSS    136 ovary OSC    74 ovary OSS    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    53 embryonic 1182-4H    41 embryonic GM2    50 embryonic Kc167    138 embryonic S1    88 embryonic S3    88 leg disc CME L1    82 wing disc CME-W2    56 wing disc ML-DmD8    75 wing disc ML-DmD9    115 wing disc ML-DmD16-c3    95 wing disc ML-DmD21    61 wing disc ML-DmD32    111 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    110 tumorous blood cells mbn2    0 ovary fGS/OSS    136 ovary OSC    74 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4  (53) embryonic 1182-4H  (41) embryonic GM2  (50) embryonic Kc167  (138) embryonic S1  (88) embryonic S3  (88) leg disc CME L1  (82) wing disc CME-W2  (56) wing disc ML-DmD8  (75) wing disc ML-DmD9  (115) wing disc ML-DmD16-c3  (95) wing disc ML-DmD21  (61) wing disc ML-DmD32  (111) haltere disc ML-DmD17-c3  (70) eye-antennal disc ML-DmD11  (44) antennal disc ML-DmD20-c5  (48) mixed discs ML-DmD4-c1  (81) CNS ML-DmBG1-c1  (50) CNS ML-DmBG2-c2  (110) tumorous blood cells mbn2    0 ovary fGS/OSS  (136) ovary OSC  (74) ovary OSS  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    53 embryonic 1182-4H    41 embryonic GM2    50 embryonic Kc167  138 embryonic S1    88 embryonic S3    88 leg disc CME L1    82 wing disc CME-W2    56 wing disc ML-DmD8    75 wing disc ML-DmD9  115 wing disc ML-DmD16-c3    95 wing disc ML-DmD21    61 wing disc ML-DmD32  111 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2  110 tumorous blood cells mbn2    0 ovary fGS/OSS  136 ovary OSC    74 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    53 embryonic 1182-4H    41 embryonic GM2    50 embryonic Kc167    138 embryonic S1    88 embryonic S3    88 leg disc CME L1    82 wing disc CME-W2    56 wing disc ML-DmD8    75 wing disc ML-DmD9    115 wing disc ML-DmD16-c3    95 wing disc ML-DmD21    61 wing disc ML-DmD32    111 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    110 tumorous blood cells mbn2    0 ovary fGS/OSS    136 ovary OSC    74 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    227 cold shock, 4-day adult    165 heat shock, 4-day adult    323 Cadmium 50 mM 6 hrs, larvae L3    139 Cadmium 50 mM 12 hrs, larvae L3    123 Cadmium 50 mM 48 hrs, 4-day adult    214 Cadmium 100 mM 48 hrs, 4-day adult    400 Copper 0.5 mM 12 hrs, larvae L3    205 Copper 15 mM 48 hrs, 4-day adult    325 Zinc 5 mM 12 hrs, larvae L3    145 Zinc 4.5 mM 48 hrs, 4-day adult    188 Ethanol 2.5% 3 hrs, larvae L3    341 Ethanol 5% 3 hrs, larvae L3    63 Ethanol 10% 3 hrs, larvae L3    89 Caffeine 1.5 mg/ml 4 hrs, larvae L3    92 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    327 Caffeine 25 mg/ml 48 hrs, 4-day adult    264 Paraquat 5 mM 48 hrs, 4-day adult    265 Paraquat 10 mM 48 hrs, 4-day adult    296 Rotenone 2 μg 12 hrs, larvae L3    106 Rotenone 8 μg 12 hrs, larvae L3    100 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (227) cold shock, 4-day adult  (165) heat shock, 4-day adult  (323) Cadmium 50 mM 6 hrs, larvae L3  (139) Cadmium 50 mM 12 hrs, larvae L3  (123) Cadmium 50 mM 48 hrs, 4-day adult  (214) Cadmium 100 mM 48 hrs, 4-day adult  (400) Copper 0.5 mM 12 hrs, larvae L3  (205) Copper 15 mM 48 hrs, 4-day adult  (325) Zinc 5 mM 12 hrs, larvae L3  (145) Zinc 4.5 mM 48 hrs, 4-day adult  (188) Ethanol 2.5% 3 hrs, larvae L3  (341) Ethanol 5% 3 hrs, larvae L3  (63) Ethanol 10% 3 hrs, larvae L3  (89) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (92) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (327) Caffeine 25 mg/ml 48 hrs, 4-day adult  (264) Paraquat 5 mM 48 hrs, 4-day adult  (265) Paraquat 10 mM 48 hrs, 4-day adult  (296) Rotenone 2 μg 12 hrs, larvae L3  (106) Rotenone 8 μg 12 hrs, larvae L3  (100) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (227) cold shock, 4-day adult  (165) heat shock, 4-day adult  (323) Cadmium 50 mM 6 hrs, larvae L3  (139) Cadmium 50 mM 12 hrs, larvae L3  (123) Cadmium 50 mM 48 hrs, 4-day adult  (214) Cadmium 100 mM 48 hrs, 4-day adult  (400) Copper 0.5 mM 12 hrs, larvae L3  (205) Copper 15 mM 48 hrs, 4-day adult  (325) Zinc 5 mM 12 hrs, larvae L3  (145) Zinc 4.5 mM 48 hrs, 4-day adult  (188) Ethanol 2.5% 3 hrs, larvae L3  (341) Ethanol 5% 3 hrs, larvae L3    63 Ethanol 10% 3 hrs, larvae L3    89 Caffeine 1.5 mg/ml 4 hrs, larvae L3    92 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (327) Caffeine 25 mg/ml 48 hrs, 4-day adult  (264) Paraquat 5 mM 48 hrs, 4-day adult  (265) Paraquat 10 mM 48 hrs, 4-day adult  (296) Rotenone 2 μg 12 hrs, larvae L3  106 Rotenone 8 μg 12 hrs, larvae L3    100 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    227 cold shock, 4-day adult    165 heat shock, 4-day adult    323 Cadmium 50 mM 6 hrs, larvae L3    139 Cadmium 50 mM 12 hrs, larvae L3    123 Cadmium 50 mM 48 hrs, 4-day adult    214 Cadmium 100 mM 48 hrs, 4-day adult    400 Copper 0.5 mM 12 hrs, larvae L3    205 Copper 15 mM 48 hrs, 4-day adult    325 Zinc 5 mM 12 hrs, larvae L3    145 Zinc 4.5 mM 48 hrs, 4-day adult    188 Ethanol 2.5% 3 hrs, larvae L3    341 Ethanol 5% 3 hrs, larvae L3    63 Ethanol 10% 3 hrs, larvae L3    89 Caffeine 1.5 mg/ml 4 hrs, larvae L3    92 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    327 Caffeine 25 mg/ml 48 hrs, 4-day adult    264 Paraquat 5 mM 48 hrs, 4-day adult    265 Paraquat 10 mM 48 hrs, 4-day adult    296 Rotenone 2 μg 12 hrs, larvae L3    106 Rotenone 8 μg 12 hrs, larvae L3    100 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    227 cold shock, 4-day adult    165 heat shock, 4-day adult    323 Cadmium 50 mM 6 hrs, larvae L3    139 Cadmium 50 mM 12 hrs, larvae L3    123 Cadmium 50 mM 48 hrs, 4-day adult    214 Cadmium 100 mM 48 hrs, 4-day adult    400 Copper 0.5 mM 12 hrs, larvae L3    205 Copper 15 mM 48 hrs, 4-day adult    325 Zinc 5 mM 12 hrs, larvae L3    145 Zinc 4.5 mM 48 hrs, 4-day adult    188 Ethanol 2.5% 3 hrs, larvae L3    341 Ethanol 5% 3 hrs, larvae L3    63 Ethanol 10% 3 hrs, larvae L3    89 Caffeine 1.5 mg/ml 4 hrs, larvae L3    92 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    327 Caffeine 25 mg/ml 48 hrs, 4-day adult    264 Paraquat 5 mM 48 hrs, 4-day adult    265 Paraquat 10 mM 48 hrs, 4-day adult    296 Rotenone 2 μg 12 hrs, larvae L3    106 Rotenone 8 μg 12 hrs, larvae L3    100 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (227) cold shock, 4-day adult  (165) heat shock, 4-day adult  (323) Cadmium 50 mM 6 hrs, larvae L3  (139) Cadmium 50 mM 12 hrs, larvae L3  (123) Cadmium 50 mM 48 hrs, 4-day adult  (214) Cadmium 100 mM 48 hrs, 4-day adult  (400) Copper 0.5 mM 12 hrs, larvae L3  (205) Copper 15 mM 48 hrs, 4-day adult  (325) Zinc 5 mM 12 hrs, larvae L3  (145) Zinc 4.5 mM 48 hrs, 4-day adult  (188) Ethanol 2.5% 3 hrs, larvae L3  (341) Ethanol 5% 3 hrs, larvae L3  (63) Ethanol 10% 3 hrs, larvae L3  (89) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (92) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (327) Caffeine 25 mg/ml 48 hrs, 4-day adult  (264) Paraquat 5 mM 48 hrs, 4-day adult  (265) Paraquat 10 mM 48 hrs, 4-day adult  (296) Rotenone 2 μg 12 hrs, larvae L3  (106) Rotenone 8 μg 12 hrs, larvae L3  (100) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (227) cold shock, 4-day adult  (165) heat shock, 4-day adult  (323) Cadmium 50 mM 6 hrs, larvae L3  139 Cadmium 50 mM 12 hrs, larvae L3  123 Cadmium 50 mM 48 hrs, 4-day adult  (214) Cadmium 100 mM 48 hrs, 4-day adult  (400) Copper 0.5 mM 12 hrs, larvae L3  (205) Copper 15 mM 48 hrs, 4-day adult  (325) Zinc 5 mM 12 hrs, larvae L3  (145) Zinc 4.5 mM 48 hrs, 4-day adult  (188) Ethanol 2.5% 3 hrs, larvae L3  (341) Ethanol 5% 3 hrs, larvae L3    63 Ethanol 10% 3 hrs, larvae L3    89 Caffeine 1.5 mg/ml 4 hrs, larvae L3    92 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (327) Caffeine 25 mg/ml 48 hrs, 4-day adult  (264) Paraquat 5 mM 48 hrs, 4-day adult  (265) Paraquat 10 mM 48 hrs, 4-day adult  (296) Rotenone 2 μg 12 hrs, larvae L3  106 Rotenone 8 μg 12 hrs, larvae L3    100 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    227 cold shock, 4-day adult    165 heat shock, 4-day adult    323 Cadmium 50 mM 6 hrs, larvae L3    139 Cadmium 50 mM 12 hrs, larvae L3    123 Cadmium 50 mM 48 hrs, 4-day adult    214 Cadmium 100 mM 48 hrs, 4-day adult    400 Copper 0.5 mM 12 hrs, larvae L3    205 Copper 15 mM 48 hrs, 4-day adult    325 Zinc 5 mM 12 hrs, larvae L3    145 Zinc 4.5 mM 48 hrs, 4-day adult    188 Ethanol 2.5% 3 hrs, larvae L3    341 Ethanol 5% 3 hrs, larvae L3    63 Ethanol 10% 3 hrs, larvae L3    89 Caffeine 1.5 mg/ml 4 hrs, larvae L3    92 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    327 Caffeine 25 mg/ml 48 hrs, 4-day adult    264 Paraquat 5 mM 48 hrs, 4-day adult    265 Paraquat 10 mM 48 hrs, 4-day adult    296 Rotenone 2 μg 12 hrs, larvae L3    106 Rotenone 8 μg 12 hrs, larvae L3    100 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • GH06230 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030608 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9057-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Lsd-2 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | non-rescuable maternal effect Lsd-21 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Lsd-2GD14108 viable Lsd-21 Lsd-2CA07051 Lsd-2KG00149 Sterility Allele fertile Lsd-21 Lsd-2KG00149 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Lsd-2GD14108 Phenotype manifest in Allele embryonic/larval fat body | larval stage Lsd-2KG00149 fat body Lsd-240 Lsd-251 Lsd-2KG00149 fat body, with Scer\GAL4Adh.PF Lsd-2Scer\UAS.cGa fat body, with Scer\GAL4fat Lsd-2Scer\UAS.cGa lipid droplet & larval oenocyte, with Scer\GAL4ppl.PP Lsd-2Scer\UAS.cGa lipid droplet | embryonic stage Lsd-2Δ1 Lsd-2Δ2 Lsd-2BG00016 lipid droplet | embryonic stage | maternal effect Lsd-2KG00149 lipid particle Lsd-2KG00149 mesothoracic tergum, with Scer\GAL4pnr-MD237 Lsd-2GD14108 nurse cell Lsd-21 nurse cell (with Lsd-21) Lsd-2KG00149 nurse cell (with Lsd-2KG00149) Lsd-21
Classical Alleles ( 18 )
For All Classical Alleles Show
Allele of Lsd-2 Class Mutagen Stocks Known lesion Lsd-2BG00016 1 Yes Lsd-2d01209 P-element activity 1 -- Lsd-2e03329 piggyBac transposase 1 -- Lsd-2EY07971 1 Yes Lsd-2f01370 piggyBac transposase 1 -- Lsd-2KG00149 loss of function allele P-element activity 1 Yes Lsd-2NP0141 P-element activity 1 -- Lsd-21 Delta2-3 0 Yes Lsd-240 P-element activity 0 Yes Lsd-25-HA-2178 0 -- Lsd-251 P-element activity 0 Yes Lsd-2CA07051 P-element activity 0 Yes Lsd-2CPTI001655 piggyBac transposase 0 Yes Lsd-2CPTI002546 piggyBac transposase 0 Yes Lsd-2GG01445 0 -- Lsd-2revKG00149 P-element activity 0 Yes Lsd-2Δ1 P-element activity 0 Yes Lsd-2Δ2 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Lsd-2 Class Mutagen Stocks Known lesion Lsd-2GD14108 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Lsd-2HMS00629 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Lsd-2HMS01292 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Lsd-2KK111306 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Lsd-2Scer\UAS.cGa in vitro construct - regulatory fusion 0 Yes Lsd-2Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Lsd-2Scer\UAS.T:Avic\GFP-EYFP 0 Yes Lsd-2Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Lsd-2Scer\UAS.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Lsd-2Ubi-p63E.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6249 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14108} NA P{KK111306} NA P{TRiP.HMS00629} NA P{TRiP.HMS01292} NA P{UAS-Lsd-2.EGFP} NA P{UAS-Lsd-2.EYFP} NA P{UAS-Lsd-2.G} NA P{UAS-Lsd-2.GFP} NA P{UAS-Lsd-2.mCherry} NA characterization construct P{UAS-Lsd-2-Lsd-1C.mCherry} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP448 NA P{EP}EP1614 NA P{EPgy2}EY07971 NA P{Mae-UAS.6.11}Lsd-2GG01445 NA P{XP}Lsd-2d01209 NA miscellaneous insertions P{GT1}Lsd-2BG00016 NA P{PTT-GA}Lsd-2CA07051 NA P{RS5}Lsd-25-HA-2178 NA P{SUPor-P}Lsd-2KG00149 NA PBac{681.P.FSVS-1}Lsd-2CPTI001655 NA PBac{681.P.FSVS-1}Lsd-2CPTI002546 NA PBac{RB}Lsd-2e03329 NA PBac{WH}Lsd-2f01370 NA insertion of enhancer trap binary system P{GawB}Lsd-2NP0141 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with klar (Welte et al., 2005)
Biological Process
CV term Evidence References
imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Carreira et al., 2011) lipid metabolic process inferred from mutant phenotype (Gutierrez et al., 2007) lipid particle transport along microtubule inferred from mutant phenotype (Welte et al., 2005) lipid storage inferred from mutant phenotype (Gronke et al., 2003) negative regulation of lipid catabolic process inferred from mutant phenotype (Bi et al., 2012) regulation of transport inferred from mutant phenotype (Welte et al., 2005) sequestering of triglyceride inferred from mutant phenotype (Teixeira et al., 2003)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006, Teixeira et al., 2003, Welte et al., 2005, Cermelli et al., 2006, Bi et al., 2012) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
lipid storage non-traceable author statement (Beller et al., 2003)
Cellular Component
CV term Evidence References
lipid particle non-traceable author statement (Beller et al., 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Lsd-2 allele Gene References unspecified bmm (Gronke et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58792 DroID - A comprehensive database of gene and protein interactions. • FBgn0030608 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32437
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG602XC8 Dipteran inclusive ortholog search EOG6MGSHC Insect inclusive ortholog search EOG6W6MS1 Arthropod inclusive ortholog search EOG6XWDDV Metazoa inclusive ortholog search EOG6MM19Q
Orthologs in Drosophila Species (EOG602XC8)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Lsd-2     Drosophila simulans   Dsim\GD15823 Y   Drosophila sechellia   Dsec\GM12009 Y   Drosophila erecta   Dere\GG19422 Y   Drosophila yakuba   Dyak\GE16074 Y   Drosophila ananassae   Dana\GF21059 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21508 Y   Drosophila persimilis   Dper\GL15208 Y   Drosophila willistoni   Dwil\GK16346 Y   Drosophila virilis   Dvir\GJ15704 Y   Drosophila mojavensis   Dmoj\GI21559 Y   Drosophila grimshawi   Dgri\GH24314 Y
Orthologs in non-Drosophila Dipterans (EOG6MGSHC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012027   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004372   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009231   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006820   Anopheles gambiae Malaria mosquito  Agam\AGAP000167   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018160
Orthologs in non-Dipteran Insects (EOG6W6MS1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Ame.4613   Apis mellifera Western honey bee  Amel\GB47141   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007790   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19994   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19993   Atta cephalotes Leafcutter ant  Acep\ACEP22543   Atta cephalotes Leafcutter ant  Acep\ACEP22567   Atta cephalotes Leafcutter ant  Acep\ACEP25030   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23263   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19059   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19060   Linepithema humile Argentine ant  Lhum\LH17703   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20977   Solenopsis invicta Red fire ant  Sinv\SINV23160   Bombyx mori Silkmoth  Bmor\BGIBMGA013612
Orthologs in non-Insect Arthropods (EOG6XWDDV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW024072   Ixodes scapularis Deer tick  Isca\ISCW012777   Ixodes scapularis Deer tick  Isca\ISCW016150   Ixodes scapularis Deer tick  Isca\ISCW001727   Ixodes scapularis Deer tick  Isca\ISCW008745   Ixodes scapularis Deer tick  Isca\ISCW000943
Orthologs in non-Arthropod Metazoa (EOG6MM19Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Gallus gallus Domestic chicken  Ggal\ENSGALG00000021972
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15823 Drosophila sechellia Dsec\GM12009 Drosophila erecta Dere\GG19422 Drosophila yakuba Dyak\GE16074 Drosophila ananassae Dana\GF21059 Drosophila pseudoobscura pseudoobscura Dpse\GA21508 Drosophila persimilis Dper\GL15208 Drosophila willistoni Dwil\GK16346 Drosophila virilis Dvir\GJ15704 Drosophila mojavensis Dmoj\GI21559 Drosophila grimshawi Dgri\GH24314
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	12398 w1118 P{GT1}Lsd-2BG00016 19733 y1 w67c23 P{EPgy2}EY07971 13382 y1 P{SUPor-P}Lsd-2KG00149; ry506 32846 y1 sc* v1; P{TRiP.HMS00629}attP2 34617 y1 sc* v1; P{TRiP.HMS01292}attP2
Harvard	- P{XP}Lsd-2d01209 - PBac{RB}Lsd-2e03329 - PBac{WH}Lsd-2f01370
Kyoto	112057 w* P{GawB}Lsd-2NP0141 / FM7c
VDRC	v102269 P{KK111306}VIE-260B v40734 w1118; P{GD14108}v40734 v40735 w1118; P{GD14108}v40735/CyO
Genomic Clones ( 2 )
	BACR09F03 BACR10J19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 231 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH06230
Other clones	DPiM_GH06230
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03463 GH07517 GH07924 GH11930 GH13252 GH13652 GH13664 GH18395 GH21627 GH23878 GH26353 GH26528 GH26916 GH27823 GH27905 GM03356 HL01095 HL07492 LD04341 LD04982 LD05652 LD06548 LD08874 LD11587 LD12893 LD22516 LD24029 LD27433 LD29632 LD32531 LD32616 LD33991 LD39785 LD40061 LD42325 LD44324 LP21993 RE02760 RE03096 RE04221 RE05036 RE07525 RE07623 RE18706 RE21859 RE22084 RE27221 RE29853 RE32072 RE36381 RE37595 RE37644 RE40995 RE50914 RE56553 RE56576 RE57945 RE58939 RE59616 RE60316 RE63979 RE67325 RE67903 RE67975 RE68051 RE69669 RH09696 RH18253 RH18736 RH19974 RH20294 RH50146 RH63489
Other clones	203 10516 11998 12750 16509 18138 29608 30376 33069 34389 36647 37302 37415 38663 39622 41524 46917 62862 64205 64255 65880 66059 67382 71480 74140 74989 78346 79561 97484 99509 100307 103181 105450 106706 118062 119337 157482 160899 163624 183398 214249.29 214307.24 214407.30 214479.32 214479.33 275079 277291 277352 281588 281942 CK01.22A.F12 CK01.25B.G5 CK01.28B.E10 CK01.30B.F3 CK01.31D.H8 CK01.33A.E5 CK01.41C.E10 CK01.50C.G5 CK01.53D.H3 CK01.56A.E8 CK01.83D.C10 CK01.89C.H4 CK01.94C.B6 CK01.95C.F3 CK01.97C.A12 CK01.97C.B12 CK01.100D.B6 CK01.106D.G4 CK01.110B.G2 CK01.113B.D7 CK01.117D.G6 CK01.130A.D9 CK01.168D.G7 Dmel_dig_002718_0706_0313 Dmel_dig_003258_0593_1702 Dmel_dig_007202_0641_0987 Dmel_dig_007217_0692_1225 Dmel_dig_008519_0639_1654 Dmel_dig_016473_0647_3583 Dmel_dig_016560_0616_2736 Dmel_neb_002742_0157_3594 Dmel_neb_008886_0903_0447 Dmel_neb_013474_0611_1306 Dmel_neb_013679_0438_2773 Dmel_neb_013975_0380_0593 Dmel_neb_014196_0140_0896 Dmel_neb_014609_0941_1313 EC25806 EC34932 EC052621 EK002710 EK020454 EK026622 EK040527 EK043430 EK045237 EK066841 EK070347 EK074322 EK074406 EK075634 EK075638 EK084705 EK085139 EK089259 EK100413 EK110346 EK112933 EK114133 EK130109 EK131339 EK143742 EK151432 EK154558 EK155662 EK156431 EK165908 EK171331 EK174247 EK187811 EK189936 EK189938 EK193224 EK193914 EK195459 EK199312 EK206948 EK207029 EK209618 EK220306 EK222246 EK223043 EK226235 EK237364 EK238419 EK238815 EK244321 EK260653 EK264450 EK288233 EK291962 EK294906 EK302820 EK304326 EK304339 EK307154 EP00953 EP06746 EP07946 ESG014a.E21_F11 FGM101A12 GH17141 MB6-CG9057-RC RH12945 RP003339658 UUGC1138
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030608 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32437
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Lsd2 CG9057 (Beller, 2002.3.17)
Source for database merge of
Additional comments
Other Comments
	Lsd-2 lack-of-function and gain-of-function studies indicate that the gene is essential for an adjustment of the organismal lipid storage level. (Beller et al., 2003) Lsd-2 is required for normal lipid storage. (Teixeira et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132768 NM_001042811 RefSeq (Proteins) • NP_572996 NP_001036276 DDBJ / EMBL / GenBank • AAF48419 AAL25281 ABI30981 ABI30982 AI106959 AI402042 AY060242 BH609997 BI371912 CZ472091 CZ481102 CZ483844 CZ483845 Entrez Gene - A searchable database of RefSeq genes. • 32437 UniProtKB/Swiss-Prot • Q9VXY7 UniProtKB/TrEMBL • Q0KHS6 Q0KHS7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Perilipin (IPR004279) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH06230
Linkouts
	BioGRID - A database of protein and genetic interactions • 58792 DroID - A comprehensive database of gene and protein interactions. • FBgn0030608 DRSC - Results from RNAi screens. • FBgn0030608 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030608 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9057-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030608 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32437 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/lipidstdr1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32437 modMine - Data generated by the modENCODE project. • FBgn0030608
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	145098_at (Kristensen et al., 2005) CG9057 (Bartolome and Maside, 2004, Butler et al., 2003, Beller et al., 2006, Cermelli et al., 2006, Ellis and Carney, 2009, Keleman et al., 2009.8.5, Hughes et al., 2008, Ni et al., 2010.12.1, Cammarato et al., 2011, Arrese et al., 2008) LSD2 (Cohen, 2005, Welte et al., 2005, Kim et al., 2005, Welte et al., 2004, Beller et al., 2004, Kim et al., 2006, Vereshchagina and Wilson, 2006, Wilson et al., 2007, Cermelli et al., 2006, Libert, 2007, Brasaemle and Hansen, 2006, Larsen et al., 2008, Vereshchagina et al., 2008, Johnson et al., 2010) Lsd2 (Teixeira et al., 2003, Greil et al., 2003, Gronke, 2003, Gronke et al., 2003, Beller, 2002.3.17, Skorupa et al., 2007, Gutierrez et al., 2007, Zhang et al., 2011, Thimgan et al., 2010, Arrese et al., 2008) LSD-2 (Miura et al., 2002, Li et al., 2012, Beller et al., 2010, Pospisilik et al., 2010, Li et al., 2012) Lsd-2 (Beller et al., 2006, Beller et al., 2006, Gronke et al., 2005, Fauny et al., 2005, Buszczak et al., 2007, Bolukbasi et al., 2012, Ellis and Carney, 2009, Carreira et al., 2009, Morozova et al., 2009, Morozova et al., 2007, Weake and Scott, 2007, Yu et al., 2011, Tian et al., 2011, Sieber and Thummel, 2009, Carreira et al., 2011) plin2 (Bi et al., 2012, Beller et al., 2010, Beller et al., 2010)
Name Synonym	Lipid storage droplet-2 (Miura et al., 2002, Morozova et al., 2007, Cammarato et al., 2011) lipid storage droplet 2 (Cermelli et al., 2006) Lipid storage droplet 2 (Rollmann et al., 2007, Lai et al., 2007, Thimgan et al., 2010) lipid storage droplet-2 (Carreira et al., 2009) Lipid Storage Droplet 2 Gene (Fauny et al., 2005) Lipid Storage Droplet protein 2 (Brasaemle and Hansen, 2006)
Secondary FlyBase IDs
References ( 74 )
Generate a list of	All references relating to this gene ( 74 )
List References by type	Research paper  ( 41 ) Supplementary material  ( 9 ) Review  ( 2 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 7 ) FlyBase analysis  ( 2 ) Conference report  ( 1 ) Website  ( 1 )
Recent research papers ( 10 )
	Bi et al., 2012, J. Cell Sci. 125(15): 3568--3577 Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization. [FBrf0219622] Bolukbasi et al., 2012, Open Biol. 2(1): 110031 Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. [FBrf0218466] Chien et al., 2012, J. Biomed. Opt. 17(12): 126001 Investigation of lipid homeostasis in living Drosophila by coherent anti-Stokes Raman scattering microscopy. [FBrf0220199] Fabian et al., 2012, Mol. Ecol. 21(19): 4748--4769 Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America. [FBrf0219505] Li et al., 2012, Curr. Biol. 22(22): 2104--2113 Lipid droplets control the maternal histone supply of Drosophila embryos. [FBrf0220040] Linford et al., 2012, PLoS Genet. 8(5): e1002668 Re-Patterning Sleep Architecture in Drosophila through Gustatory Perception and Nutritional Quality. [FBrf0218228] Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Tian et al., 2011, PLoS Genet. 7(4): e1001364 Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. [FBrf0213596] Yu et al., 2011, BMC Cell Biol. 12: 9 Targeting the motor regulator Klar to lipid droplets. [FBrf0213230] Zhang et al., 2011, Dev. Biol. 353(2): 259--265 Drosophila long-chain acyl-CoA synthetase acts like a gap gene in embryonic segmentation. [FBrf0213522] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...