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Gene Dmel\Cyp4s3

General Information
Symbol	Dmel\Cyp4s3	Species	D. melanogaster
Name	Cyp4s3	Annotation symbol	CG9081
Feature type	protein_coding_gene	FlyBase ID	FBgn0030615
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	13A12-13A12	Sequence location	X:15,007,335..15,010,572 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyp4s3 is referred to in FlyBase by the symbol Dmel\Cyp4s3 (CG9081, FBgn0030615). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: electron carrier activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cytochrome P450; Cytochrome P450, E-class, group I; Cytochrome P450, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed at stages throughout the larval period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, adult Malpighian tubules, larval fat body. Comments on Affy2 ProbeSet: ProbeSet 1636688_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cyp4s3. Gene sequence location is X:15007335..15010572.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN31985 HFA20241 References Niwa et al., 2011, Appl. Ent. Zool. 46(4): 533--543
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 13A12-13A12   Limits computationally determined from genome sequence between P{EP}hiwEP1308 and P{EP}Ahcy13EP1007
Experimentally Determined Cytological Location
Cytogenetic map Notes References 13A2-13C1     (Dunkov, 2000.6.29)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cyp4s3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cyp4s3-RA FBtr0074028  NM_132775   2285   495
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cyp4s3-PA   FBpp0073845   57.2   495   9.23     NP_573003   AAF48426
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome P450 (IPR001128) Cytochrome P450, E-class, group I (IPR002401) Cytochrome P450, conserved site (IPR017972)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48426   AI261013   AY071583 AAL49205   BI376043   CZ466827   CZ467186
UniProtKB/Swiss-Prot	Q9VXY0
UniProtKB/TrEMBL	Q8SYF6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030615    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030615 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed at stages throughout the larval period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030615 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    6 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    78 embryo 16-18hr    405 embryo 18-20hr    1133 embryo 20-22hr    915 embryo 22-24hr    1100 larva L1    1720 larva L2    2200 larva L3 12hr old    2482 larva L3 puffstage 1-2    2801 larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    424 white prepupae new    214 white prepupae 12hr    136 white prepupae 24hr    95 pupae 2d postWPP    768 pupae 3d postWPP    1143 pupae 4d postWPP    1384 adult male 01day    1428 adult male 05day    507 adult male 30day    514 adult female 01day    1297 adult female 05day    1593 adult female 30day    1244 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    6 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    78 embryo 16-18hr  (405) embryo 18-20hr  (1133) embryo 20-22hr  (915) embryo 22-24hr  (1100) larva L1  (1720) larva L2  (2200) larva L3 12hr old  (2482) larva L3 puffstage 1-2  (2801) larva L3 puffstage 3-6  (1171) larva L3 puffstage 7-9  (424) white prepupae new  (214) white prepupae 12hr  (136) white prepupae 24hr    95 pupae 2d postWPP  (768) pupae 3d postWPP  (1143) pupae 4d postWPP  (1384) adult male 01day  (1428) adult male 05day  (507) adult male 30day  (514) adult female 01day  (1297) adult female 05day  (1593) adult female 30day  (1244) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    6 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    78 embryo 16-18hr    405 embryo 18-20hr    1133 embryo 20-22hr    915 embryo 22-24hr    1100 larva L1  (1720) larva L2  (2200) larva L3 12hr old  (2482) larva L3 puffstage 1-2  (2801) larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    424 white prepupae new    214 white prepupae 12hr    136 white prepupae 24hr    95 pupae 2d postWPP    768 pupae 3d postWPP    1143 pupae 4d postWPP    1384 adult male 01day  1428 adult male 05day    507 adult male 30day    514 adult female 01day    1297 adult female 05day  (1593) adult female 30day    1244 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    6 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    78 embryo 16-18hr    405 embryo 18-20hr    1133 embryo 20-22hr    915 embryo 22-24hr    1100 larva L1    1720 larva L2    2200 larva L3 12hr old    2482 larva L3 puffstage 1-2    2801 larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    424 white prepupae new    214 white prepupae 12hr    136 white prepupae 24hr    95 pupae 2d postWPP    768 pupae 3d postWPP    1143 pupae 4d postWPP    1384 adult male 01day    1428 adult male 05day    507 adult male 30day    514 adult female 01day    1297 adult female 05day    1593 adult female 30day    1244 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    6 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    78 embryo 16-18hr    405 embryo 18-20hr    1133 embryo 20-22hr    915 embryo 22-24hr    1100 larva L1    1720 larva L2    2200 larva L3 12hr old    2482 larva L3 puffstage 1-2    2801 larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    424 white prepupae new    214 white prepupae 12hr    136 white prepupae 24hr    95 pupae 2d postWPP    768 pupae 3d postWPP    1143 pupae 4d postWPP    1384 adult male 01day    1428 adult male 05day    507 adult male 30day    514 adult female 01day    1297 adult female 05day    1593 adult female 30day    1244 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030615 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    6 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    78 embryo 16-18hr    405 embryo 18-20hr    1133 embryo 20-22hr    915 embryo 22-24hr    1100 larva L1    1720 larva L2    2200 larva L3 12hr old    2482 larva L3 puffstage 1-2    2801 larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    424 white prepupae new    214 white prepupae 12hr    136 white prepupae 24hr    95 pupae 2d postWPP    768 pupae 3d postWPP    1143 pupae 4d postWPP    1384 adult male 01day    1428 adult male 05day    507 adult male 30day    514 adult female 01day    1297 adult female 05day    1593 adult female 30day    1244 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    6 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    78 embryo 16-18hr  (405) embryo 18-20hr  (1133) embryo 20-22hr  (915) embryo 22-24hr  (1100) larva L1  (1720) larva L2  (2200) larva L3 12hr old  (2482) larva L3 puffstage 1-2  (2801) larva L3 puffstage 3-6  (1171) larva L3 puffstage 7-9  (424) white prepupae new  (214) white prepupae 12hr  136 white prepupae 24hr    95 pupae 2d postWPP  (768) pupae 3d postWPP  (1143) pupae 4d postWPP  (1384) adult male 01day  (1428) adult male 05day  (507) adult male 30day  (514) adult female 01day  (1297) adult female 05day  (1593) adult female 30day  (1244) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    6 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    78 embryo 16-18hr    405 embryo 18-20hr    1133 embryo 20-22hr    915 embryo 22-24hr    1100 larva L1  1720 larva L2  2200 larva L3 12hr old  (2482) larva L3 puffstage 1-2  (2801) larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    424 white prepupae new    214 white prepupae 12hr    136 white prepupae 24hr    95 pupae 2d postWPP    768 pupae 3d postWPP    1143 pupae 4d postWPP    1384 adult male 01day  1428 adult male 05day    507 adult male 30day    514 adult female 01day    1297 adult female 05day  1593 adult female 30day    1244 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    6 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    78 embryo 16-18hr    405 embryo 18-20hr    1133 embryo 20-22hr    915 embryo 22-24hr    1100 larva L1    1720 larva L2    2200 larva L3 12hr old    2482 larva L3 puffstage 1-2    2801 larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    424 white prepupae new    214 white prepupae 12hr    136 white prepupae 24hr    95 pupae 2d postWPP    768 pupae 3d postWPP    1143 pupae 4d postWPP    1384 adult male 01day    1428 adult male 05day    507 adult male 30day    514 adult female 01day    1297 adult female 05day    1593 adult female 30day    1244 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    6 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    78 embryo 16-18hr    405 embryo 18-20hr    1133 embryo 20-22hr    915 embryo 22-24hr    1100 larva L1    1720 larva L2    2200 larva L3 12hr old    2482 larva L3 puffstage 1-2    2801 larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    424 white prepupae new    214 white prepupae 12hr    136 white prepupae 24hr    95 pupae 2d postWPP    768 pupae 3d postWPP    1143 pupae 4d postWPP    1384 adult male 01day    1428 adult male 05day    507 adult male 30day    514 adult female 01day    1297 adult female 05day    1593 adult female 30day    1244 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030615    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030615 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, adult Malpighian tubules, larval fat body. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030615 expression level Tissue   Expression Level Larval Central Nervous System    10.9 Larval Midgut    5.4 Larval Hindgut    33.9 Larval Malpighian Tubules    7.6 Larval Fat Body    202.6 Larval Salivary Gland    30.9 Larval Trachea    6.875 Larval Carcass no informative data Adult Head    22.6 Adult Eye    26.675 Adult Brain    59.5 Adult Thoracic-Abdominal Ganglion    65 Adult Crop    5.4 Adult Midgut    52.8 Adult Hindgut    112.6 Adult Malpighian Tubules    100.1 Adult Fat Body    65.5 Adult Salivary Gland    2.7 Adult Heart    27.4 Adult VirginFemale Spermatheca    43.2 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    29.4 Adult Testis    3.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    10.9 Larval Midgut    5.4 Larval Hindgut    33.9 Larval Malpighian Tubules    7.6 Larval Fat Body    202.6 Larval Salivary Gland    30.9 Larval Trachea    6.875 Larval Carcass no informative data Adult Head    22.6 Adult Eye    26.675 Adult Brain    59.5 Adult Thoracic-Abdominal Ganglion    65 Adult Crop    5.4 Adult Midgut    52.8 Adult Hindgut    112.6 Adult Malpighian Tubules    100.1 Adult Fat Body    65.5 Adult Salivary Gland    2.7 Adult Heart    27.4 Adult VirginFemale Spermatheca    43.2 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    29.4 Adult Testis    3.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    10.9 Larval Midgut    5.4 Larval Hindgut    33.9 Larval Malpighian Tubules    7.6 Larval Fat Body    202.6 Larval Salivary Gland    30.9 Larval Trachea    6.875 Larval Carcass no informative data Adult Head    22.6 Adult Eye    26.675 Adult Brain    59.5 Adult Thoracic-Abdominal Ganglion    65 Adult Crop    5.4 Adult Midgut    52.8 Adult Hindgut    112.6 Adult Malpighian Tubules    100.1 Adult Fat Body    65.5 Adult Salivary Gland    2.7 Adult Heart    27.4 Adult VirginFemale Spermatheca    43.2 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    29.4 Adult Testis    3.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    10.9 Larval Midgut    5.4 Larval Hindgut    33.9 Larval Malpighian Tubules    7.6 Larval Fat Body    202.6 Larval Salivary Gland    30.9 Larval Trachea    6.875 Larval Carcass no informative data Adult Head    22.6 Adult Eye    26.675 Adult Brain    59.5 Adult Thoracic-Abdominal Ganglion    65 Adult Crop    5.4 Adult Midgut    52.8 Adult Hindgut    112.6 Adult Malpighian Tubules    100.1 Adult Fat Body    65.5 Adult Salivary Gland    2.7 Adult Heart    27.4 Adult VirginFemale Spermatheca    43.2 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    29.4 Adult Testis    3.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030615 expression level Tissue   Expression Level Larval Central Nervous System    10.9 Larval Midgut    5.4 Larval Hindgut    33.9 Larval Malpighian Tubules    7.6 Larval Fat Body    202.6 Larval Salivary Gland    30.9 Larval Trachea    6.875 Larval Carcass no informative data Adult Head    22.6 Adult Eye    26.675 Adult Brain    59.5 Adult Thoracic-Abdominal Ganglion    65 Adult Crop    5.4 Adult Midgut    52.8 Adult Hindgut    112.6 Adult Malpighian Tubules    100.1 Adult Fat Body    65.5 Adult Salivary Gland    2.7 Adult Heart    27.4 Adult VirginFemale Spermatheca    43.2 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    29.4 Adult Testis    3.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    10.9 Larval Midgut    5.4 Larval Hindgut    33.9 Larval Malpighian Tubules    7.6 Larval Fat Body    202.6 Larval Salivary Gland    30.9 Larval Trachea    6.875 Larval Carcass no informative data Adult Head    22.6 Adult Eye    26.675 Adult Brain    59.5 Adult Thoracic-Abdominal Ganglion    65 Adult Crop    5.4 Adult Midgut    52.8 Adult Hindgut    112.6 Adult Malpighian Tubules    100.1 Adult Fat Body    65.5 Adult Salivary Gland    2.7 Adult Heart    27.4 Adult VirginFemale Spermatheca    43.2 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    29.4 Adult Testis    3.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    10.9 Larval Midgut    5.4 Larval Hindgut    33.9 Larval Malpighian Tubules    7.6 Larval Fat Body    202.6 Larval Salivary Gland    30.9 Larval Trachea    6.875 Larval Carcass no informative data Adult Head    22.6 Adult Eye    26.675 Adult Brain    59.5 Adult Thoracic-Abdominal Ganglion    65 Adult Crop    5.4 Adult Midgut    52.8 Adult Hindgut    112.6 Adult Malpighian Tubules    100.1 Adult Fat Body    65.5 Adult Salivary Gland    2.7 Adult Heart    27.4 Adult VirginFemale Spermatheca    43.2 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    29.4 Adult Testis    3.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    10.9 Larval Midgut    5.4 Larval Hindgut    33.9 Larval Malpighian Tubules    7.6 Larval Fat Body    202.6 Larval Salivary Gland    30.9 Larval Trachea    6.875 Larval Carcass no informative data Adult Head    22.6 Adult Eye    26.675 Adult Brain    59.5 Adult Thoracic-Abdominal Ganglion    65 Adult Crop    5.4 Adult Midgut    52.8 Adult Hindgut    112.6 Adult Malpighian Tubules    100.1 Adult Fat Body    65.5 Adult Salivary Gland    2.7 Adult Heart    27.4 Adult VirginFemale Spermatheca    43.2 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    29.4 Adult Testis    3.1 Adult Male Accessory Gland    5.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    22.6   NA  Eye    26.675   NA  Brain    59.5   10.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    65   NA  Crop    5.4   5.4  Midgut    52.8   33.9  Hindgut    112.6   7.6  Malpighian Tubules    100.1   202.6  Fat Body    65.5   30.9  Salivary Gland    2.7   NA  Heart    27.4   6.875  Trachea    NA   NA  VirginFemale Spermatheca    43.2   NA  InseminatedFemale Spermatheca    46.1   NA  Ovary    29.4   NA  Testis    3.1   NA  Male Accessory Gland    5.6   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030615 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9081-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Cyp4s3c01459 viable, with Scer\GAL4pnr-MD237 Cyp4s3GD6307 Sterility Allele fertile Cyp4s3c01459 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Cyp4s3 Class Mutagen Stocks Known lesion Cyp4s3c01459 piggyBac transposase 2 -- Cyp4s3MB01696 1 -- Cyp4s3c01032 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cyp4s3 Class Mutagen Stocks Known lesion Cyp4s3GD6307 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6249 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6307} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}Cyp4s3c01032 NA PBac{PB}Cyp4s3c01459 NA insertion of enhancer trap binary system Mi{ET1}Cyp4s3MB01696 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
electron carrier activity inferred from electronic annotation with InterPro:IPR001128 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Dunkov, 1999.11) non-traceable author statement (Dunkov, 2000.6.29, Swiss-Prot Project Members, 2000.5.1) heme binding inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401 (FlyBase Curators et al., 2004-) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
oxidation-reduction process inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
membrane non-traceable author statement (Swiss-Prot Project Members, 2000.5.1) microsome non-traceable author statement (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cyp4s3 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58799 DroID - A comprehensive database of gene and protein interactions. • FBgn0030615 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32444
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21055 Dere\GG19418 Dgri\GH24311 Dmoj\GI21555 Dper\GL15203 Dpse\GA21527 Dsec\GM12005 Dvir\GJ15699 Dwil\GK16415 Dyak\GE16069
Curated drosophilid orthologs	Dpac\Cyp4s3   Dpse\GA21527
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • At1g67110.1 Arabidopsis thaliana (wall cress) At2g26710.1 Arabidopsis thaliana (wall cress) At3g14660.1 Arabidopsis thaliana (wall cress) At5g38450.1 Arabidopsis thaliana (wall cress) 39257 Chlamidomonas reinhardtii (green alga) ENSGACP00000018421 Gymnopilus aculeatus (mushroom) ENSGACP00000019413 Gymnopilus aculeatus (mushroom) ENSOANP00000004202 Ornithorynchus anatinus (platypus) ENSOANP00000008145 Ornithorynchus anatinus (platypus) 23029 Ostreococcus tauri (green alga) 27418 Ostreococcus tauri (green alga) 110612 Physcomitrella patens (moss) 188189 Physcomitrella patens (moss) 197852 Physcomitrella patens (moss) ENSPPYP00000001605 Pongo pygmaeus (orangutan) ENSPPYP00000010843 Pongo pygmaeus (orangutan) 417000 Populus trichocarpa (black cottonwood) 424485 Populus trichocarpa (black cottonwood) 589522 Populus trichocarpa (black cottonwood) ENSRNOP00000006335 Rattus norvegicus (norway rat) ENSRNOP00000053925 Rattus norvegicus (norway rat) 14.m00450 Tetrahymena thermophila (ciliate protozoa) 17.m00341 Tetrahymena thermophila (ciliate protozoa) 306.m00029 Tetrahymena thermophila (ciliate protozoa) 7.m00365 Tetrahymena thermophila (ciliate protozoa) 7.m00377 Tetrahymena thermophila (ciliate protozoa) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233618 FBgn0218417 FBgn0202887 FBgn0166946 FBgn0081513 FBgn0152807 FBgn0144285 FBgn0131767 FBgn0111621 FBgn0098060
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	10545 w1118 PBac{PB}Cyp4s3c01459 23398 w1118 Mi{ET1}Cyp4s3MB01696
Harvard	- PBac{PB}Cyp4s3c01459
VDRC	v38217 w1118; P{GD6307}v38217 v38218 w1118; P{GD6307}v38218
Genomic Clones ( 1 )
	BACR09F03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE63964
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP05075
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030615 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32444
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132775 RefSeq (Proteins) • NP_573003 DDBJ / EMBL / GenBank • AAF48426 AAL49205 AY071583 BI376043 CZ466827 CZ467186 Entrez Gene - A searchable database of RefSeq genes. • 32444 UniProtKB/Swiss-Prot • Q9VXY0 UniProtKB/TrEMBL • Q8SYF6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome P450 (IPR001128) Cytochrome P450, E-class, group I (IPR002401) Cytochrome P450, conserved site (IPR017972)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58799 DroID - A comprehensive database of gene and protein interactions. • FBgn0030615 DRSC - Results from RNAi screens. • FBgn0030615 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030615 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9081-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030615 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32444 InParanoid A subset of ortholog calls from InParanoid. • At1g67110.1 Arabidopsis thaliana (wall cress) At2g26710.1 Arabidopsis thaliana (wall cress) At3g14660.1 Arabidopsis thaliana (wall cress) At5g38450.1 Arabidopsis thaliana (wall cress) 39257 Chlamidomonas reinhardtii (green alga) ENSGACP00000018421 Gymnopilus aculeatus (mushroom) ENSGACP00000019413 Gymnopilus aculeatus (mushroom) ENSOANP00000004202 Ornithorynchus anatinus (platypus) ENSOANP00000008145 Ornithorynchus anatinus (platypus) 23029 Ostreococcus tauri (green alga) 27418 Ostreococcus tauri (green alga) 110612 Physcomitrella patens (moss) 188189 Physcomitrella patens (moss) 197852 Physcomitrella patens (moss) ENSPPYP00000001605 Pongo pygmaeus (orangutan) ENSPPYP00000010843 Pongo pygmaeus (orangutan) 417000 Populus trichocarpa (black cottonwood) 424485 Populus trichocarpa (black cottonwood) 589522 Populus trichocarpa (black cottonwood) ENSRNOP00000006335 Rattus norvegicus (norway rat) ENSRNOP00000053925 Rattus norvegicus (norway rat) 14.m00450 Tetrahymena thermophila (ciliate protozoa) 17.m00341 Tetrahymena thermophila (ciliate protozoa) 306.m00029 Tetrahymena thermophila (ciliate protozoa) 7.m00365 Tetrahymena thermophila (ciliate protozoa) 7.m00377 Tetrahymena thermophila (ciliate protozoa) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32444 modMine - Data generated by the modENCODE project. • FBgn0030615 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233618 FBgn0218417 FBgn0202887 FBgn0166946 FBgn0081513 FBgn0152807 FBgn0144285 FBgn0131767 FBgn0111621 FBgn0098060
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	4s3 (Nelson, 2001.2.5) CG9081   Cyp4s3 (Niwa et al., 2011, King-Jones et al., 2006)
Name Synonym	Cyp4s3   cytochrome P450 (Chung et al., 2009)
Secondary FlyBase IDs
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 4 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Niwa et al., 2011, Appl. Ent. Zool. 46(4): 533--543 Expressions of the cytochrome P450 monooxygenase gene Cyp4g1 and its homolog in the prothoracic glands of the fruit fly Drosophila melanogaster (Diptera: Drosophilidae) and the silkworm Bombyx mori (Lepidoptera: Bombycidae). [FBrf0216541] Show all research papers ...