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Gene Dmel\cerv

General Information
Symbol	Dmel\cerv	Species	D. melanogaster
Name	cervantes	Annotation symbol	CG15645
Feature type	protein_coding_gene	FlyBase ID	FBgn0030657
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	13D4-13D4	Sequence location	X:15,471,019..15,472,031 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cervantes is referred to in FlyBase by the symbol Dmel\cerv (CG15645, FBgn0030657). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: SUMO ligase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: positive regulation of mitotic metaphase/anaphase transition; double-strand break repair via homologous recombination; positive regulation of maintenance of mitotic sister chromatid cohesion. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: E3 SUMO-protein ligase Nse2 (Mms21). Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1641733_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of cerv. Gene sequence location is X:15471019..15472031.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 13D4-13D4   Limits computationally determined from genome sequence between P{EP}CG6340EP1109&P{EP}l(1)G0168EP491 and P{EP}EP1489
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cerv for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cerv-RA FBtr0089702  NM_132815   968   230 cerv-RC FBtr0310052  NM_167453   952   177
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cerv-PA   FBpp0088643   26.1   230   5.22     NP_573043   AAF48475 cerv-PC   FBpp0301753   20.0   177   6.40     NP_727868   AAN09357
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • E3 SUMO-protein ligase Nse2 (Mms21) (IPR026846)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48475   AE014298 AAN09357   BE976598   BI362365   BT011022   BT022708   BT022759   BT022834   BT030832   BT124827   CO194985   CO285785   CO287808   CO345048   CZ481694   CZ481695   EC070057   EC081324   EC256383
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VXT3 Q8IR31
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    104.675 Larval Midgut    12 Larval Hindgut    24.3 Larval Malpighian Tubules    19.9 Larval Fat Body    32.8 Larval Salivary Gland    63.1 Larval Trachea    49 Larval Carcass    33.75 Adult Head    42.2 Adult Eye    47.275 Adult Brain    101.9 Adult Thoracic-Abdominal Ganglion    84 Adult Crop    45.1 Adult Midgut    13 Adult Hindgut    27.5 Adult Malpighian Tubules    16.1 Adult Fat Body    18.1 Adult Salivary Gland    72 Adult Heart    17 Adult VirginFemale Spermatheca    30.9 Adult InseminatedFemale Spermatheca    50.1 Adult Ovary    78.3 Adult Testis    51.5 Adult Male Accessory Gland    48.8 Adult Carcass    17.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    104.675 Larval Midgut    12 Larval Hindgut    24.3 Larval Malpighian Tubules    19.9 Larval Fat Body    32.8 Larval Salivary Gland    63.1 Larval Trachea    49 Larval Carcass    33.75 Adult Head    42.2 Adult Eye    47.275 Adult Brain    101.9 Adult Thoracic-Abdominal Ganglion    84 Adult Crop    45.1 Adult Midgut    13 Adult Hindgut    27.5 Adult Malpighian Tubules    16.1 Adult Fat Body    18.1 Adult Salivary Gland    72 Adult Heart    17 Adult VirginFemale Spermatheca    30.9 Adult InseminatedFemale Spermatheca    50.1 Adult Ovary    78.3 Adult Testis    51.5 Adult Male Accessory Gland    48.8 Adult Carcass    17.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    104.675 Larval Midgut    12 Larval Hindgut    24.3 Larval Malpighian Tubules    19.9 Larval Fat Body    32.8 Larval Salivary Gland    63.1 Larval Trachea    49 Larval Carcass    33.75 Adult Head    42.2 Adult Eye    47.275 Adult Brain    101.9 Adult Thoracic-Abdominal Ganglion    84 Adult Crop    45.1 Adult Midgut    13 Adult Hindgut    27.5 Adult Malpighian Tubules    16.1 Adult Fat Body    18.1 Adult Salivary Gland    72 Adult Heart    17 Adult VirginFemale Spermatheca    30.9 Adult InseminatedFemale Spermatheca    50.1 Adult Ovary    78.3 Adult Testis    51.5 Adult Male Accessory Gland    48.8 Adult Carcass    17.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    104.675 Larval Midgut    12 Larval Hindgut    24.3 Larval Malpighian Tubules    19.9 Larval Fat Body    32.8 Larval Salivary Gland    63.1 Larval Trachea    49 Larval Carcass    33.75 Adult Head    42.2 Adult Eye    47.275 Adult Brain    101.9 Adult Thoracic-Abdominal Ganglion    84 Adult Crop    45.1 Adult Midgut    13 Adult Hindgut    27.5 Adult Malpighian Tubules    16.1 Adult Fat Body    18.1 Adult Salivary Gland    72 Adult Heart    17 Adult VirginFemale Spermatheca    30.9 Adult InseminatedFemale Spermatheca    50.1 Adult Ovary    78.3 Adult Testis    51.5 Adult Male Accessory Gland    48.8 Adult Carcass    17.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    104.675 Larval Midgut    12 Larval Hindgut    24.3 Larval Malpighian Tubules    19.9 Larval Fat Body    32.8 Larval Salivary Gland    63.1 Larval Trachea    49 Larval Carcass    33.75 Adult Head    42.2 Adult Eye    47.275 Adult Brain    101.9 Adult Thoracic-Abdominal Ganglion    84 Adult Crop    45.1 Adult Midgut    13 Adult Hindgut    27.5 Adult Malpighian Tubules    16.1 Adult Fat Body    18.1 Adult Salivary Gland    72 Adult Heart    17 Adult VirginFemale Spermatheca    30.9 Adult InseminatedFemale Spermatheca    50.1 Adult Ovary    78.3 Adult Testis    51.5 Adult Male Accessory Gland    48.8 Adult Carcass    17.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    104.675 Larval Midgut    12 Larval Hindgut    24.3 Larval Malpighian Tubules    19.9 Larval Fat Body    32.8 Larval Salivary Gland    63.1 Larval Trachea    49 Larval Carcass    33.75 Adult Head    42.2 Adult Eye    47.275 Adult Brain    101.9 Adult Thoracic-Abdominal Ganglion    84 Adult Crop    45.1 Adult Midgut    13 Adult Hindgut    27.5 Adult Malpighian Tubules    16.1 Adult Fat Body    18.1 Adult Salivary Gland    72 Adult Heart    17 Adult VirginFemale Spermatheca    30.9 Adult InseminatedFemale Spermatheca    50.1 Adult Ovary    78.3 Adult Testis    51.5 Adult Male Accessory Gland    48.8 Adult Carcass    17.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    104.675 Larval Midgut    12 Larval Hindgut    24.3 Larval Malpighian Tubules    19.9 Larval Fat Body    32.8 Larval Salivary Gland    63.1 Larval Trachea    49 Larval Carcass    33.75 Adult Head    42.2 Adult Eye    47.275 Adult Brain    101.9 Adult Thoracic-Abdominal Ganglion    84 Adult Crop    45.1 Adult Midgut    13 Adult Hindgut    27.5 Adult Malpighian Tubules    16.1 Adult Fat Body    18.1 Adult Salivary Gland    72 Adult Heart    17 Adult VirginFemale Spermatheca    30.9 Adult InseminatedFemale Spermatheca    50.1 Adult Ovary    78.3 Adult Testis    51.5 Adult Male Accessory Gland    48.8 Adult Carcass    17.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    104.675 Larval Midgut    12 Larval Hindgut    24.3 Larval Malpighian Tubules    19.9 Larval Fat Body    32.8 Larval Salivary Gland    63.1 Larval Trachea    49 Larval Carcass    33.75 Adult Head    42.2 Adult Eye    47.275 Adult Brain    101.9 Adult Thoracic-Abdominal Ganglion    84 Adult Crop    45.1 Adult Midgut    13 Adult Hindgut    27.5 Adult Malpighian Tubules    16.1 Adult Fat Body    18.1 Adult Salivary Gland    72 Adult Heart    17 Adult VirginFemale Spermatheca    30.9 Adult InseminatedFemale Spermatheca    50.1 Adult Ovary    78.3 Adult Testis    51.5 Adult Male Accessory Gland    48.8 Adult Carcass    17.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    42.2   NA  Eye    47.275   NA  Brain    101.9   104.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    84   NA  Crop    45.1   no informative data  Midgut    no informative data   24.3  Hindgut    27.5   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   63.1  Salivary Gland    72   NA  Heart    17   49  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    50.1   NA  Ovary    78.3   NA  Testis    51.5   NA  Male Accessory Gland    48.8   33.75  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    18 ovary, mated 4-day female    11 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    18 ovary, mated 4-day female    11 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    18 ovary, mated 4-day female    11 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    18 ovary, mated 4-day female    11 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    18 ovary, mated 4-day female    11 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    18 ovary, mated 4-day female    11 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    18 ovary, mated 4-day female    11 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    5 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    18 ovary, mated 4-day female    11 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    24 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    20 embryo 12-14hr    12 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    9 white prepupae new    7 white prepupae 12hr    12 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    24 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    20 embryo 12-14hr    12 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    9 white prepupae new    7 white prepupae 12hr    12 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    24 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    20 embryo 12-14hr    12 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    9 white prepupae new    7 white prepupae 12hr    12 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    24 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    20 embryo 12-14hr    12 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    9 white prepupae new    7 white prepupae 12hr    12 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    24 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    20 embryo 12-14hr    12 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    9 white prepupae new    7 white prepupae 12hr    12 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    24 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    20 embryo 12-14hr    12 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    9 white prepupae new    7 white prepupae 12hr    12 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    24 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    20 embryo 12-14hr    12 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    9 white prepupae new    7 white prepupae 12hr    12 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    24 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    23 embryo 10-12hr    20 embryo 12-14hr    12 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    9 white prepupae new    7 white prepupae 12hr    12 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    5 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    17 embryonic 1182-4H    15 embryonic GM2    7 embryonic Kc167    26 embryonic S1    9 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    28 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    6 ovary fGS/OSS    15 ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    17 embryonic 1182-4H    15 embryonic GM2    7 embryonic Kc167  26 embryonic S1    9 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    8 wing disc ML-DmD21  (28) wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    6 ovary fGS/OSS    15 ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    17 embryonic 1182-4H    15 embryonic GM2    7 embryonic Kc167    26 embryonic S1    9 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    28 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    6 ovary fGS/OSS    15 ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    17 embryonic 1182-4H    15 embryonic GM2    7 embryonic Kc167    26 embryonic S1    9 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    28 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    6 ovary fGS/OSS    15 ovary OSC    18 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    17 embryonic 1182-4H    15 embryonic GM2    7 embryonic Kc167    26 embryonic S1    9 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    28 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    6 ovary fGS/OSS    15 ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    17 embryonic 1182-4H    15 embryonic GM2    7 embryonic Kc167  26 embryonic S1    9 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    8 wing disc ML-DmD21  28 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    6 ovary fGS/OSS    15 ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    17 embryonic 1182-4H    15 embryonic GM2    7 embryonic Kc167    26 embryonic S1    9 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    28 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    6 ovary fGS/OSS    15 ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    17 embryonic 1182-4H    15 embryonic GM2    7 embryonic Kc167    26 embryonic S1    9 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    15 wing disc ML-DmD8    10 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    28 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    6 ovary fGS/OSS    15 ovary OSC    18 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • RE46906 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030657 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15645-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 cervGD9081 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of cerv Class Mutagen Stocks Known lesion cerve03931 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cerv Class Mutagen Stocks Known lesion cervGD17749 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cervGD9081 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cervKK111440 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cervNIG.15645R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK111440} NA P{NIG.15645R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}cerve03931 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
SUMO ligase activity inferred from electronic annotation with InterPro:IPR026846 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
double-strand break repair via homologous recombination inferred from electronic annotation with InterPro:IPR026846 (FlyBase Curators et al., 2004-) positive regulation of maintenance of mitotic sister chromatid cohesion inferred from electronic annotation with InterPro:IPR026846 (FlyBase Curators et al., 2004-) positive regulation of mitotic metaphase/anaphase transition inferred from electronic annotation with InterPro:IPR026846 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
Smc5-Smc6 complex inferred from electronic annotation with InterPro:IPR026846 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cerv allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0030657
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6R7VX6 Dipteran inclusive ortholog search EOG6PG693 Insect inclusive ortholog search EOG60VTM4 Arthropod inclusive ortholog search EOG6T4BBZ Metazoa inclusive ortholog search EOG6ZH27F, EOG63C0HF
Orthologs in Drosophila Species (EOG6R7VX6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG42299     Drosophila melanogaster fruit fly  Dmel\qjt     Drosophila melanogaster fruit fly  Dmel\cerv     Drosophila simulans   Dsim\cerv   Y Drosophila simulans   Dsim\qjt   Y Drosophila sechellia   Dsec\GM22549   Y Drosophila sechellia   Dsec\GM22550   Y Drosophila sechellia   Dsec\GM22546   Y Drosophila sechellia   Dsec\qjt   Y Drosophila erecta   Dere\cerv   Y Drosophila erecta   Dere\GG11876   Y Drosophila yakuba   Dyak\GE26335   Y Drosophila yakuba   Dyak\cerv   Y Drosophila ananassae   Dana\GF22252   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA25188   Y Drosophila persimilis   Dper\GL25912   Y Drosophila willistoni   Dwil\GK19230   Y Drosophila virilis   Dvir\GJ19226   Y Drosophila mojavensis   Dmoj\GI15639   Y Drosophila grimshawi   Dgri\GH22621   Y
Orthologs in non-Drosophila Dipterans (EOG6PG693)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001425 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007405 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007402 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009304 Y
Orthologs in non-Dipteran Insects (EOG60VTM4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47047 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005315 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16296 Y Atta cephalotes Leafcutter ant  Acep\ACEP16651 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO17411 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19138 Y Linepithema humile Argentine ant  Lhum\LH18941 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11662 Y Solenopsis invicta Red fire ant  Sinv\SINV12358 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009363 Y Pediculus humanus Human body louse  Phum\PHUM498080 Y Tribolium castaneum Red flour beetle  Tcas\TC005834 Y
Orthologs in non-Insect Arthropods (EOG6T4BBZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_307540 Y
Orthologs in non-Arthropod Metazoa (EOG6ZH27F, EOG63C0HF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ZK1248.11 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010714gn Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Harvard	- PBac{RB}cerve03931
VDRC	v103221 P{KK111440}VIE-260B v20206 w1118; P{GD9081}v20206 v52291 w1118; P{GD17749}v52291
Genomic Clones ( 2 )
	BACR02B12 BACR28A23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 15 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP07225 IP07325 IP07425 RE46906
Other clones	DPiM_IP07325 IP07525 MIP22128
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	214511.35 bs53f01 CK01.77D.C11 CK01.83D.D10 EC39552 EK060710 EK066845 EP21206
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030657 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32492
Antibody Information
Other Information
Discoverer
Etymology
	Named after the book 'El ingenioso hidalgo Don Quijote de la Mancha' by Miguel de Cervantes Saavedra, in which the main character names himself 'Quijote'. ("qjt" (quijote) is a young retroposed gene, and "cerv" (cervantes) is its parental gene.) (Betran et al., 2006)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: cerv CG15645 (Betran et al., 2006)
Source for database merge of
Additional comments	The CG13732 gene may have been derived from the CG15645 gene by retroposition. (Dai et al., 2006) The CG13732 gene may be derived from the CG15645 gene by retroposition. (Betran et al., 2002)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132815 NM_167453 RefSeq (Proteins) • NP_573043 NP_727868 DDBJ / EMBL / GenBank • AAF48475 AAN09357 BI362365 CZ481694 CZ481695 Entrez Gene - A searchable database of RefSeq genes. • 32492 UniProtKB/TrEMBL • Q8IR31 Q9VXT3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • E3 SUMO-protein ligase Nse2 (Mms21) (IPR026846) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE46906
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0030657 DRSC - Results from RNAi screens. • FBgn0030657 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030657 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15645-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030657 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32492 modMine - Data generated by the modENCODE project. • FBgn0030657
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	cerv (Betran et al., 2006) CG15645 (Conant and Wagner, 2003, Betran et al., 2006, Dai et al., 2006, Thornton and Long, 2005, Keleman et al., 2009.8.5, Bai et al., 2007, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	cervantes (Bai et al., 2007) Cervantes (Betran et al., 2006) CG15645
Secondary FlyBase IDs
References ( 20 )
Research paper	Díaz-Castillo and Ranz, 2012, Mol. Biol. Evol. 29(9): 2105--2108 Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. [FBrf0219274] Bai et al., 2007, Genome Biol. 8(1): R11 Comparative genomics reveals a constant rate of origination and convergent acquisition of functional retrogenes in Drosophila. [FBrf0192134] Betran et al., 2006, Mol. Biol. Evol. 23(11): 2191--2202 Fast protein evolution and germ line expression of a Drosophila parental gene and its young retroposed paralog. [FBrf0192808] Dai et al., 2006, Gene 385: 96--102 Retrogene movement within- and between-chromosomes in the evolution of Drosophila genomes. [FBrf0194437] Thornton and Long, 2005, Mol. Biol. Evol. 22(2): 273--284 Excess of Amino Acid Substitutions Relative to Polymorphism Between X-Linked Duplications in Drosophila melanogaster. [FBrf0180520] Conant and Wagner, 2003, Genome Res. 13(9): 2052--2058 Asymmetric sequence divergence of duplicate genes. [FBrf0167689] Betran et al., 2002, Genome Res. 12(12): 1854--1859 Retroposed new genes out of the X in Drosophila. [FBrf0155820]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file) Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]