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Gene Dmel\CG8239

General Information
Symbol	Dmel\CG8239	Species	D. melanogaster
Name		Annotation symbol	CG8239
Feature type	protein_coding_gene	FlyBase ID	FBgn0030683
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	13E14-13E14	Sequence location	X:15,643,210..15,645,255 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG8239 (FBgn0030683). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: diphosphomevalonate decarboxylase activity. Based on sequence similarity, it is predicted to be involved in the biological process: isoprenoid biosynthetic process. 2 alleles are reported. The phenotype of these alleles is annotated with: tormogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Diphosphomevalonate decarboxylase; GHMP kinase; GHMP kinase, C-terminal; Ribosomal protein S5 domain 2-type fold; Ribosomal protein S5 domain 2-type fold, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1637066_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG8239. Gene sequence location is X:15643210..15645255.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN22694 BKN50926 BKN50334 HFA20096
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 13E14-13E14   Limits computationally determined from genome sequence between P{EP}EP1489 and P{EP}BEST:RE35685EP1581&P{EP}sdEP1088
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG8239 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG8239-RA FBtr0074087  NM_132840   1529   388
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG8239-PA   FBpp0073903   42.8   388   6.83     NP_573068   AAF48505
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Diphosphomevalonate decarboxylase (IPR005935) GHMP kinase (IPR006204) Ribosomal protein S5 domain 2-type fold, subgroup (IPR014721) GHMP kinase, C-terminal (IPR013750) Ribosomal protein S5 domain 2-type fold (IPR020568)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391934   AE014298 AAF48505   AW942160   AY069410 AAL39555   BI164413   BI164421   CO179257   CO187123   CO263724   CO267317   CO286314   CO297375   CO314050   CO326467   EC056939   EC057511   EC072965   EC207438   EC217176   EC231375   EC235486   EC247803   EC253519   EC256835   EV581692
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VXQ3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030683    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030683 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030683 expression level Developmental Stage   Expression Level embryo 00-02hr    2518 embryo 02-04hr    684 embryo 04-06hr    464 embryo 06-08hr    769 embryo 08-10hr    945 embryo 10-12hr    2193 embryo 12-14hr    2425 embryo 14-16hr    8224 embryo 16-18hr    1618 embryo 18-20hr    420 embryo 20-22hr    340 embryo 22-24hr    378 larva L1    559 larva L2    2401 larva L3 12hr old    591 larva L3 puffstage 1-2    257 larva L3 puffstage 3-6    331 larva L3 puffstage 7-9    403 white prepupae new    467 white prepupae 12hr    521 white prepupae 24hr    703 pupae 2d postWPP    4016 pupae 3d postWPP    726 pupae 4d postWPP    375 adult male 01day    204 adult male 05day    263 adult male 30day    309 adult female 01day    835 adult female 05day    1426 adult female 30day    1456 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2518) embryo 02-04hr  (684) embryo 04-06hr  (464) embryo 06-08hr  (769) embryo 08-10hr  (945) embryo 10-12hr  (2193) embryo 12-14hr  (2425) embryo 14-16hr  (8224) embryo 16-18hr  (1618) embryo 18-20hr  (420) embryo 20-22hr  (340) embryo 22-24hr  (378) larva L1  (559) larva L2  (2401) larva L3 12hr old  (591) larva L3 puffstage 1-2  (257) larva L3 puffstage 3-6  (331) larva L3 puffstage 7-9  (403) white prepupae new  (467) white prepupae 12hr  (521) white prepupae 24hr  (703) pupae 2d postWPP  (4016) pupae 3d postWPP  (726) pupae 4d postWPP  (375) adult male 01day  (204) adult male 05day  (263) adult male 30day  (309) adult female 01day  (835) adult female 05day  (1426) adult female 30day  (1456) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2518) embryo 02-04hr    684 embryo 04-06hr    464 embryo 06-08hr    769 embryo 08-10hr    945 embryo 10-12hr  (2193) embryo 12-14hr  (2425) embryo 14-16hr  (8224) embryo 16-18hr  (1618) embryo 18-20hr    420 embryo 20-22hr    340 embryo 22-24hr    378 larva L1    559 larva L2  (2401) larva L3 12hr old    591 larva L3 puffstage 1-2    257 larva L3 puffstage 3-6    331 larva L3 puffstage 7-9    403 white prepupae new    467 white prepupae 12hr    521 white prepupae 24hr    703 pupae 2d postWPP  (4016) pupae 3d postWPP    726 pupae 4d postWPP    375 adult male 01day    204 adult male 05day    263 adult male 30day    309 adult female 01day    835 adult female 05day  1426 adult female 30day  1456 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2518 embryo 02-04hr    684 embryo 04-06hr    464 embryo 06-08hr    769 embryo 08-10hr    945 embryo 10-12hr    2193 embryo 12-14hr    2425 embryo 14-16hr    8224 embryo 16-18hr    1618 embryo 18-20hr    420 embryo 20-22hr    340 embryo 22-24hr    378 larva L1    559 larva L2    2401 larva L3 12hr old    591 larva L3 puffstage 1-2    257 larva L3 puffstage 3-6    331 larva L3 puffstage 7-9    403 white prepupae new    467 white prepupae 12hr    521 white prepupae 24hr    703 pupae 2d postWPP    4016 pupae 3d postWPP    726 pupae 4d postWPP    375 adult male 01day    204 adult male 05day    263 adult male 30day    309 adult female 01day    835 adult female 05day    1426 adult female 30day    1456 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2518 embryo 02-04hr    684 embryo 04-06hr    464 embryo 06-08hr    769 embryo 08-10hr    945 embryo 10-12hr    2193 embryo 12-14hr    2425 embryo 14-16hr    8224 embryo 16-18hr    1618 embryo 18-20hr    420 embryo 20-22hr    340 embryo 22-24hr    378 larva L1    559 larva L2    2401 larva L3 12hr old    591 larva L3 puffstage 1-2    257 larva L3 puffstage 3-6    331 larva L3 puffstage 7-9    403 white prepupae new    467 white prepupae 12hr    521 white prepupae 24hr    703 pupae 2d postWPP    4016 pupae 3d postWPP    726 pupae 4d postWPP    375 adult male 01day    204 adult male 05day    263 adult male 30day    309 adult female 01day    835 adult female 05day    1426 adult female 30day    1456 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030683 expression level Developmental Stage   Expression Level embryo 00-02hr    2518 embryo 02-04hr    684 embryo 04-06hr    464 embryo 06-08hr    769 embryo 08-10hr    945 embryo 10-12hr    2193 embryo 12-14hr    2425 embryo 14-16hr    8224 embryo 16-18hr    1618 embryo 18-20hr    420 embryo 20-22hr    340 embryo 22-24hr    378 larva L1    559 larva L2    2401 larva L3 12hr old    591 larva L3 puffstage 1-2    257 larva L3 puffstage 3-6    331 larva L3 puffstage 7-9    403 white prepupae new    467 white prepupae 12hr    521 white prepupae 24hr    703 pupae 2d postWPP    4016 pupae 3d postWPP    726 pupae 4d postWPP    375 adult male 01day    204 adult male 05day    263 adult male 30day    309 adult female 01day    835 adult female 05day    1426 adult female 30day    1456 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2518) embryo 02-04hr  (684) embryo 04-06hr  (464) embryo 06-08hr  (769) embryo 08-10hr  (945) embryo 10-12hr  (2193) embryo 12-14hr  (2425) embryo 14-16hr  (8224) embryo 16-18hr  (1618) embryo 18-20hr  (420) embryo 20-22hr  (340) embryo 22-24hr  (378) larva L1  (559) larva L2  (2401) larva L3 12hr old  (591) larva L3 puffstage 1-2  (257) larva L3 puffstage 3-6  (331) larva L3 puffstage 7-9  (403) white prepupae new  (467) white prepupae 12hr  (521) white prepupae 24hr  (703) pupae 2d postWPP  (4016) pupae 3d postWPP  (726) pupae 4d postWPP  (375) adult male 01day  (204) adult male 05day  (263) adult male 30day  (309) adult female 01day  (835) adult female 05day  (1426) adult female 30day  (1456) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2518) embryo 02-04hr    684 embryo 04-06hr    464 embryo 06-08hr    769 embryo 08-10hr    945 embryo 10-12hr  2193 embryo 12-14hr  2425 embryo 14-16hr  (8224) embryo 16-18hr  1618 embryo 18-20hr    420 embryo 20-22hr    340 embryo 22-24hr    378 larva L1    559 larva L2  2401 larva L3 12hr old    591 larva L3 puffstage 1-2    257 larva L3 puffstage 3-6    331 larva L3 puffstage 7-9    403 white prepupae new    467 white prepupae 12hr    521 white prepupae 24hr    703 pupae 2d postWPP  (4016) pupae 3d postWPP    726 pupae 4d postWPP    375 adult male 01day    204 adult male 05day    263 adult male 30day    309 adult female 01day    835 adult female 05day  1426 adult female 30day  1456 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2518 embryo 02-04hr    684 embryo 04-06hr    464 embryo 06-08hr    769 embryo 08-10hr    945 embryo 10-12hr    2193 embryo 12-14hr    2425 embryo 14-16hr    8224 embryo 16-18hr    1618 embryo 18-20hr    420 embryo 20-22hr    340 embryo 22-24hr    378 larva L1    559 larva L2    2401 larva L3 12hr old    591 larva L3 puffstage 1-2    257 larva L3 puffstage 3-6    331 larva L3 puffstage 7-9    403 white prepupae new    467 white prepupae 12hr    521 white prepupae 24hr    703 pupae 2d postWPP    4016 pupae 3d postWPP    726 pupae 4d postWPP    375 adult male 01day    204 adult male 05day    263 adult male 30day    309 adult female 01day    835 adult female 05day    1426 adult female 30day    1456 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2518 embryo 02-04hr    684 embryo 04-06hr    464 embryo 06-08hr    769 embryo 08-10hr    945 embryo 10-12hr    2193 embryo 12-14hr    2425 embryo 14-16hr    8224 embryo 16-18hr    1618 embryo 18-20hr    420 embryo 20-22hr    340 embryo 22-24hr    378 larva L1    559 larva L2    2401 larva L3 12hr old    591 larva L3 puffstage 1-2    257 larva L3 puffstage 3-6    331 larva L3 puffstage 7-9    403 white prepupae new    467 white prepupae 12hr    521 white prepupae 24hr    703 pupae 2d postWPP    4016 pupae 3d postWPP    726 pupae 4d postWPP    375 adult male 01day    204 adult male 05day    263 adult male 30day    309 adult female 01day    835 adult female 05day    1426 adult female 30day    1456 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030683    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030683 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030683 expression level Tissue   Expression Level Larval Central Nervous System    60.55 Larval Midgut    35 Larval Hindgut    57.4 Larval Malpighian Tubules    25.2 Larval Fat Body no informative data Larval Salivary Gland    23.4 Larval Trachea    45.65 Larval Carcass    58.775 Adult Head    25.4 Adult Eye    11.875 Adult Brain    29 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    66.8 Adult Midgut    22.7 Adult Hindgut    23.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.4 Adult Salivary Gland no informative data Adult Heart    46.5 Adult VirginFemale Spermatheca    12.1 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    170 Adult Testis    16.6 Adult Male Accessory Gland no informative data Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    60.55 Larval Midgut    35 Larval Hindgut    57.4 Larval Malpighian Tubules    25.2 Larval Fat Body no informative data Larval Salivary Gland    23.4 Larval Trachea    45.65 Larval Carcass    58.775 Adult Head    25.4 Adult Eye    11.875 Adult Brain    29 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    66.8 Adult Midgut    22.7 Adult Hindgut    23.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.4 Adult Salivary Gland no informative data Adult Heart    46.5 Adult VirginFemale Spermatheca    12.1 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    170 Adult Testis    16.6 Adult Male Accessory Gland no informative data Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    60.55 Larval Midgut    35 Larval Hindgut    57.4 Larval Malpighian Tubules    25.2 Larval Fat Body no informative data Larval Salivary Gland    23.4 Larval Trachea    45.65 Larval Carcass    58.775 Adult Head    25.4 Adult Eye    11.875 Adult Brain    29 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    66.8 Adult Midgut    22.7 Adult Hindgut    23.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.4 Adult Salivary Gland no informative data Adult Heart    46.5 Adult VirginFemale Spermatheca    12.1 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    170 Adult Testis    16.6 Adult Male Accessory Gland no informative data Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    60.55 Larval Midgut    35 Larval Hindgut    57.4 Larval Malpighian Tubules    25.2 Larval Fat Body no informative data Larval Salivary Gland    23.4 Larval Trachea    45.65 Larval Carcass    58.775 Adult Head    25.4 Adult Eye    11.875 Adult Brain    29 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    66.8 Adult Midgut    22.7 Adult Hindgut    23.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.4 Adult Salivary Gland no informative data Adult Heart    46.5 Adult VirginFemale Spermatheca    12.1 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    170 Adult Testis    16.6 Adult Male Accessory Gland no informative data Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030683 expression level Tissue   Expression Level Larval Central Nervous System    60.55 Larval Midgut    35 Larval Hindgut    57.4 Larval Malpighian Tubules    25.2 Larval Fat Body no informative data Larval Salivary Gland    23.4 Larval Trachea    45.65 Larval Carcass    58.775 Adult Head    25.4 Adult Eye    11.875 Adult Brain    29 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    66.8 Adult Midgut    22.7 Adult Hindgut    23.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.4 Adult Salivary Gland no informative data Adult Heart    46.5 Adult VirginFemale Spermatheca    12.1 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    170 Adult Testis    16.6 Adult Male Accessory Gland no informative data Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    60.55 Larval Midgut    35 Larval Hindgut    57.4 Larval Malpighian Tubules    25.2 Larval Fat Body no informative data Larval Salivary Gland    23.4 Larval Trachea    45.65 Larval Carcass    58.775 Adult Head    25.4 Adult Eye    11.875 Adult Brain    29 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    66.8 Adult Midgut    22.7 Adult Hindgut    23.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.4 Adult Salivary Gland no informative data Adult Heart    46.5 Adult VirginFemale Spermatheca    12.1 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    170 Adult Testis    16.6 Adult Male Accessory Gland no informative data Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    60.55 Larval Midgut    35 Larval Hindgut    57.4 Larval Malpighian Tubules    25.2 Larval Fat Body no informative data Larval Salivary Gland    23.4 Larval Trachea    45.65 Larval Carcass    58.775 Adult Head    25.4 Adult Eye    11.875 Adult Brain    29 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    66.8 Adult Midgut    22.7 Adult Hindgut    23.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.4 Adult Salivary Gland no informative data Adult Heart    46.5 Adult VirginFemale Spermatheca    12.1 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    170 Adult Testis    16.6 Adult Male Accessory Gland no informative data Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    60.55 Larval Midgut    35 Larval Hindgut    57.4 Larval Malpighian Tubules    25.2 Larval Fat Body no informative data Larval Salivary Gland    23.4 Larval Trachea    45.65 Larval Carcass    58.775 Adult Head    25.4 Adult Eye    11.875 Adult Brain    29 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    66.8 Adult Midgut    22.7 Adult Hindgut    23.1 Adult Malpighian Tubules no informative data Adult Fat Body    37.4 Adult Salivary Gland no informative data Adult Heart    46.5 Adult VirginFemale Spermatheca    12.1 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    170 Adult Testis    16.6 Adult Male Accessory Gland no informative data Adult Carcass    39.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    25.4   NA  Eye    11.875   NA  Brain    29   60.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    13.1   NA  Crop    66.8   35  Midgut    22.7   57.4  Hindgut    23.1   25.2  Malpighian Tubules    no informative data   no informative data  Fat Body    37.4   23.4  Salivary Gland    no informative data   NA  Heart    46.5   45.65  Trachea    NA   NA  VirginFemale Spermatheca    12.1   NA  InseminatedFemale Spermatheca    15.2   NA  Ovary    170   NA  Testis    16.6   NA  Male Accessory Gland    no informative data   58.775  Carcass    39.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030683 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8239-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG8239 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG8239GD13855 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 CG8239GD13855 Phenotype manifest in Allele tormogen cell, with Scer\GAL4pnr-MD237 CG8239GD13855
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG8239 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG8239 Class Mutagen Stocks Known lesion CG8239GD13855 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG8239KK102628 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6250 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13855} NA P{KK102628} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(1)G0352G0352 No P{lacW}l(1)G0437G0437 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data on: 2009-11-05)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR006204 (FlyBase Curators et al., 2004-) diphosphomevalonate decarboxylase activity inferred from sequence or structural similarity with human MVD (Santos and Lehmann, 2004) kinase activity inferred from electronic annotation with InterPro:IPR006204 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
isoprenoid biosynthetic process inferred from sequence or structural similarity with human MVD (Santos and Lehmann, 2004) phosphorylation inferred from electronic annotation with InterPro:IPR006204 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG8239 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58869 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030683 DroID - A comprehensive database of gene and protein interactions. • FBgn0030683 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32520
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15902 Dere\GG17907 Dgri\GH20637 Dmoj\GI19000 Dper\GL14496 Dpse\GA20922 Dvir\GJ19966 Dwil\GK17667 Dyak\GE17215
Curated drosophilid orthologs	Dpse\GA20922
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004050-PA Aedes aegypti (mosquito) AGAP001611-PA Anopheles gambiae (mosquito) XP_001121619.1 Apis mellifera (honey bee) XP_001946501.1 Acyrthosiphon pisum (pea aphid) At3g54250.1 Arabidopsis thaliana (wall cress) 34046 Batrachochytrium dendrobatidis (chytrid fungus) 287932 Branchiostoma floridae (lancelet) BGIBMGA007459-PA Bombyx mori (silk worm) ENSBTAP00000015994 Bos taurus (bovine) CAL0005938 Candida albicans (a form of yeast) CN16839 Caenorhabditis brenneri (small nematode) CN27251 Caenorhabditis brenneri (small nematode) CBP11656 Caenorhabditis briggsae (nematode) CE22129 Caenorhabditis elegans (worm) ENSCAFP00000029448 Canis familiaris (dog) CAGL0C03630g Candida glabrata (haploid yeast) ENSCINP00000010736 Ciona intestinalis (sea squirt) cn09188 Cryptococcus neoformans (yeast-like fungus) CPIJ003140 Culex pipens (mosquito) ENSCPOP00000017693 Cavia porcellus (guinea pig) RP06291 Caenorhabditis remanei (nematode) 176844 Capitella spl (polychaete worm) DDB0252847 Dictyostelium discoideum (amoeba) DEHA2A13398g Debaryomyces Hansenii (yeast) 301631 Daphnia pulex (daphnia) ENSDARP00000030569 Danio rerio (zebra fish) ENSECAP00000009063 Equus caballus (horse) ENSGACP00000021039 Gymnopilus aculeatus (mushroom) ENSGALP00000011755 Gallus gallus (chicken) GL50803_23420 Giardia lamblia (flagellated protozoan) 185177 Hypsipyla robusta (cedar shoot borer) ENSP00000301012 Homo sapiens (human) ISCW022273-PA Ixodes scapularis (deer tick) KLLA0F10285g Kluyveromyces lactis (yeast) 211321 Lottia gigantea (owl limpet) LmjF18.0020 Leishmania major (virus) 26828 Monocosta brevicollis (choanoflagellate) ENSMODP00000005168 Monodelphis domestica (gray opossum) ENSMMUP00000018812 Macaca mulatta (rhesus monkey) ENSMUSP00000006692 Mus musculus (house mouse) 118942 Nematostella vectensis (starlet anemone) XP_001600914.1 Nasonia vitripennis (wasp) ENSOANP00000018012 Ornithorynchus anatinus (platypus) ENSORLP00000011725 Oryzias latipes (japanese killifish) LOC_Os02g01920.1 Oryza sativa (asian rice) PHUM005813-PA Pediculus humanus (human body louse) 107613 Physcomitrella patens (moss) ENSPPYP00000008619 Pongo pygmaeus (orangutan) 93670 Phytophthora ramorum (sudden oak death pathogen) 108502 Phytophthora sojae (root rot pathogen) 655777 Populus trichocarpa (black cottonwood) ENSPTRP00000014423 Pan troglodytes (chimpanzee) ENSRNOP00000018145 Rattus norvegicus (norway rat) 144842 Sorghum bicolor (sorghum) YNR043W Saccharomyces cerevisiae (budding yeast) Smp_172660 Schistosoma mansoni (trematode parasite) SPAC24C9.03 Schizosaccharomyces pombe (fission yeast) 55561 Trichoplax adhaerens (metazoa) XP_970108.1 Tribolium castaneum (red flour beetle) Tc00.1047053507993.330 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511281.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000012157 Tetraodon nigroviridis (green spotted pufferfish) 15226 Thalassiosira pseudonana (marine diatom) ENSTRUP00000046485 Takifugu rubripes (pufferfish Takifugu) 3750.m00277 Tetrahymena thermophila (ciliate protozoa) 90417.m00134 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000037910 Xenopus tropicalis (frog) YALI0F05632g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13065 NV12107 LH21071 ISCW022273 FBgn0234693 FBgn0219666 FBgn0207108 FBgn0177445 JGI_V11_301631 FBgn0080911 FBgn0152101 FBgn0141739 FBgn0128100 FBgn0110127 FBgn0092925 CPIJ003140 BGIBMGA007459 ACYPI001935 ACYPI000972 ACYPI000229 GB16296 AGAP001611 AAEL004050 PHUM582500 GLEAN_03224
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v107034 P{KK102628}VIE-260B v24254 w1118; P{GD13855}v24254 v24253 w1118; P{GD13855}v24253/TM3
Genomic Clones ( 2 )
	BACR22H11 BACR25C18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 23 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD10857
Other clones	DPiM_LD10857
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE04080 RE04088
Other clones	34453 70709 83239 214411.35 214533.32 CK01.1D.C11 CK01.4A.C9 CK01.29D.H12 CK01.80C.B12 CK01.107B.C9 Dmel_dig_003827_0644_3531 EK026348 EK058902 EK062438 EK089411 EK149426 EK216831 EK234803 EP03955
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030683 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32520
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	"l(1)G0437" may affect "CG8239". "l(1)G0352" may affect "CG8239". (Peter et al., 2002)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132840 RefSeq (Proteins) • NP_573068 DDBJ / EMBL / GenBank • AA391934 AAF48505 AAL39555 AW942160 AY069410 Entrez Gene - A searchable database of RefSeq genes. • 32520 UniProtKB/TrEMBL • Q9VXQ3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Diphosphomevalonate decarboxylase (IPR005935) GHMP kinase (IPR006204) Ribosomal protein S5 domain 2-type fold, subgroup (IPR014721) GHMP kinase, C-terminal (IPR013750) Ribosomal protein S5 domain 2-type fold (IPR020568)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58869 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030683 DroID - A comprehensive database of gene and protein interactions. • FBgn0030683 DRSC - Results from RNAi screens. • FBgn0030683 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030683 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8239-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030683 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32520 InParanoid A subset of ortholog calls from InParanoid. • AAEL004050-PA Aedes aegypti (mosquito) AGAP001611-PA Anopheles gambiae (mosquito) XP_001121619.1 Apis mellifera (honey bee) XP_001946501.1 Acyrthosiphon pisum (pea aphid) At3g54250.1 Arabidopsis thaliana (wall cress) 34046 Batrachochytrium dendrobatidis (chytrid fungus) 287932 Branchiostoma floridae (lancelet) BGIBMGA007459-PA Bombyx mori (silk worm) ENSBTAP00000015994 Bos taurus (bovine) CAL0005938 Candida albicans (a form of yeast) CN16839 Caenorhabditis brenneri (small nematode) CN27251 Caenorhabditis brenneri (small nematode) CBP11656 Caenorhabditis briggsae (nematode) CE22129 Caenorhabditis elegans (worm) ENSCAFP00000029448 Canis familiaris (dog) CAGL0C03630g Candida glabrata (haploid yeast) ENSCINP00000010736 Ciona intestinalis (sea squirt) cn09188 Cryptococcus neoformans (yeast-like fungus) CPIJ003140 Culex pipens (mosquito) ENSCPOP00000017693 Cavia porcellus (guinea pig) RP06291 Caenorhabditis remanei (nematode) 176844 Capitella spl (polychaete worm) DDB0252847 Dictyostelium discoideum (amoeba) DEHA2A13398g Debaryomyces Hansenii (yeast) 301631 Daphnia pulex (daphnia) ENSDARP00000030569 Danio rerio (zebra fish) ENSECAP00000009063 Equus caballus (horse) ENSGACP00000021039 Gymnopilus aculeatus (mushroom) ENSGALP00000011755 Gallus gallus (chicken) GL50803_23420 Giardia lamblia (flagellated protozoan) 185177 Hypsipyla robusta (cedar shoot borer) ENSP00000301012 Homo sapiens (human) ISCW022273-PA Ixodes scapularis (deer tick) KLLA0F10285g Kluyveromyces lactis (yeast) 211321 Lottia gigantea (owl limpet) LmjF18.0020 Leishmania major (virus) 26828 Monocosta brevicollis (choanoflagellate) ENSMODP00000005168 Monodelphis domestica (gray opossum) ENSMMUP00000018812 Macaca mulatta (rhesus monkey) ENSMUSP00000006692 Mus musculus (house mouse) 118942 Nematostella vectensis (starlet anemone) XP_001600914.1 Nasonia vitripennis (wasp) ENSOANP00000018012 Ornithorynchus anatinus (platypus) ENSORLP00000011725 Oryzias latipes (japanese killifish) LOC_Os02g01920.1 Oryza sativa (asian rice) PHUM005813-PA Pediculus humanus (human body louse) 107613 Physcomitrella patens (moss) ENSPPYP00000008619 Pongo pygmaeus (orangutan) 93670 Phytophthora ramorum (sudden oak death pathogen) 108502 Phytophthora sojae (root rot pathogen) 655777 Populus trichocarpa (black cottonwood) ENSPTRP00000014423 Pan troglodytes (chimpanzee) ENSRNOP00000018145 Rattus norvegicus (norway rat) 144842 Sorghum bicolor (sorghum) YNR043W Saccharomyces cerevisiae (budding yeast) Smp_172660 Schistosoma mansoni (trematode parasite) SPAC24C9.03 Schizosaccharomyces pombe (fission yeast) 55561 Trichoplax adhaerens (metazoa) XP_970108.1 Tribolium castaneum (red flour beetle) Tc00.1047053507993.330 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511281.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000012157 Tetraodon nigroviridis (green spotted pufferfish) 15226 Thalassiosira pseudonana (marine diatom) ENSTRUP00000046485 Takifugu rubripes (pufferfish Takifugu) 3750.m00277 Tetrahymena thermophila (ciliate protozoa) 90417.m00134 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000037910 Xenopus tropicalis (frog) YALI0F05632g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32520 modMine - Data generated by the modENCODE project. • FBgn0030683 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13065 NV12107 LH21071 ISCW022273 FBgn0234693 FBgn0219666 FBgn0207108 FBgn0177445 JGI_V11_301631 FBgn0080911 FBgn0152101 FBgn0141739 FBgn0128100 FBgn0110127 FBgn0092925 CPIJ003140 BGIBMGA007459 ACYPI001935 ACYPI000972 ACYPI000229 GB16296 AGAP001611 AAEL004050 PHUM582500 GLEAN_03224
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG8239 (Keleman et al., 2009.8.5, Santos and Lehmann, 2004, Pospisilik et al., 2010, Metta and Schlötterer, 2010)
Name Synonym
Secondary FlyBase IDs
References ( 16 )
Research paper	Metta and Schlötterer, 2010, BMC Evol. Biol. 10: 114 Non-random genomic integration - an intrinsic property of retrogenes in Drosophila? [FBrf0210914] Pospisilik et al., 2010, Cell 140(1): 148--160 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. [FBrf0212676] Santos and Lehmann, 2004, Dev. Cell 6(2): 283--293 Isoprenoids control germ cell migration downstream of HMGCoA reductase. [FBrf0174539]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Peter et al., 2002, EMBO Rpts 3(1): Supplementary material. PX-lines.txt. [FBrf0173176]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Ketchum, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126677]