• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\CG8952

General Information
Symbol	Dmel\CG8952	Species	D. melanogaster
Name		Annotation symbol	CG8952
Feature type	protein_coding_gene	FlyBase ID	FBgn0030688
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	13E14-13E14	Sequence location	X:15,659,503..15,660,478 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG8952 (FBgn0030688). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: serine-type endopeptidase activity. It is reported to be involved in the biological process: proteolysis. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase S1; Peptidase S1, trypsin family, active site; Peptidase S1A, chymotrypsin-type; Trypsin-like cysteine/serine peptidase domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed during late larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, adult hindgut, larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut. Comments on Affy2 ProbeSet: ProbeSet 1629007_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG8952. Gene sequence location is X:15659503..15660478.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 13E14-13E14   Limits computationally determined from genome sequence between P{EP}EP1489 and P{EP}BEST:RE35685EP1581&P{EP}sdEP1088
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG8952 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG8952-RA FBtr0074193  NM_132844   902   276
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG8952-PA   FBpp0073978   29.9   276   3.96     NP_573072   AAF48510
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S1 (IPR001254) Peptidase S1A, chymotrypsin-type (IPR001314) Trypsin-like cysteine/serine peptidase domain (IPR009003) Peptidase S1, trypsin family, active site (IPR018114)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48510   AI386815   AI386956   AW940648   AY060723 AAL28271   CO343613   EC051077   EC052595   EC054075   EC054579   EC055772   EC056484   EC056604   EC082237   EC217304   EC219696   EC259592
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VXP8 Q7K2R3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, adult hindgut, larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3.975 Larval Midgut    4062.2 Larval Hindgut    473.1 Larval Malpighian Tubules    1933 Larval Fat Body    15.1 Larval Salivary Gland    5.4 Larval Trachea    7.275 Larval Carcass    7 Adult Head    10.7 Adult Eye    6.5 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    5.1 Adult Crop    10.1 Adult Midgut    4349.4 Adult Hindgut    519.7 Adult Malpighian Tubules    3105.1 Adult Fat Body    10.5 Adult Salivary Gland    11.1 Adult Heart    6.675 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    3.2 Adult Testis    7.6 Adult Male Accessory Gland    3 Adult Carcass    14.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.975 Larval Midgut  (4062.2) Larval Hindgut    473.1 Larval Malpighian Tubules  (1933) Larval Fat Body    15.1 Larval Salivary Gland    5.4 Larval Trachea    7.275 Larval Carcass    7 Adult Head    10.7 Adult Eye    6.5 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    5.1 Adult Crop    10.1 Adult Midgut  (4349.4) Adult Hindgut  519.7 Adult Malpighian Tubules  (3105.1) Adult Fat Body    10.5 Adult Salivary Gland    11.1 Adult Heart    6.675 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    3.2 Adult Testis    7.6 Adult Male Accessory Gland    3 Adult Carcass    14.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.975 Larval Midgut  (4062.2) Larval Hindgut    473.1 Larval Malpighian Tubules  (1933) Larval Fat Body    15.1 Larval Salivary Gland    5.4 Larval Trachea    7.275 Larval Carcass    7 Adult Head    10.7 Adult Eye    6.5 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    5.1 Adult Crop    10.1 Adult Midgut  (4349.4) Adult Hindgut    519.7 Adult Malpighian Tubules  (3105.1) Adult Fat Body    10.5 Adult Salivary Gland    11.1 Adult Heart    6.675 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    3.2 Adult Testis    7.6 Adult Male Accessory Gland    3 Adult Carcass    14.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.975 Larval Midgut    4062.2 Larval Hindgut    473.1 Larval Malpighian Tubules    1933 Larval Fat Body    15.1 Larval Salivary Gland    5.4 Larval Trachea    7.275 Larval Carcass    7 Adult Head    10.7 Adult Eye    6.5 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    5.1 Adult Crop    10.1 Adult Midgut    4349.4 Adult Hindgut    519.7 Adult Malpighian Tubules    3105.1 Adult Fat Body    10.5 Adult Salivary Gland    11.1 Adult Heart    6.675 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    3.2 Adult Testis    7.6 Adult Male Accessory Gland    3 Adult Carcass    14.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3.975 Larval Midgut    4062.2 Larval Hindgut    473.1 Larval Malpighian Tubules    1933 Larval Fat Body    15.1 Larval Salivary Gland    5.4 Larval Trachea    7.275 Larval Carcass    7 Adult Head    10.7 Adult Eye    6.5 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    5.1 Adult Crop    10.1 Adult Midgut    4349.4 Adult Hindgut    519.7 Adult Malpighian Tubules    3105.1 Adult Fat Body    10.5 Adult Salivary Gland    11.1 Adult Heart    6.675 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    3.2 Adult Testis    7.6 Adult Male Accessory Gland    3 Adult Carcass    14.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.975 Larval Midgut  (4062.2) Larval Hindgut    473.1 Larval Malpighian Tubules  (1933) Larval Fat Body    15.1 Larval Salivary Gland    5.4 Larval Trachea    7.275 Larval Carcass    7 Adult Head    10.7 Adult Eye    6.5 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    5.1 Adult Crop    10.1 Adult Midgut  (4349.4) Adult Hindgut  519.7 Adult Malpighian Tubules  (3105.1) Adult Fat Body    10.5 Adult Salivary Gland    11.1 Adult Heart    6.675 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    3.2 Adult Testis    7.6 Adult Male Accessory Gland    3 Adult Carcass    14.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.975 Larval Midgut  (4062.2) Larval Hindgut    473.1 Larval Malpighian Tubules  (1933) Larval Fat Body    15.1 Larval Salivary Gland    5.4 Larval Trachea    7.275 Larval Carcass    7 Adult Head    10.7 Adult Eye    6.5 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    5.1 Adult Crop    10.1 Adult Midgut  (4349.4) Adult Hindgut    519.7 Adult Malpighian Tubules  (3105.1) Adult Fat Body    10.5 Adult Salivary Gland    11.1 Adult Heart    6.675 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    3.2 Adult Testis    7.6 Adult Male Accessory Gland    3 Adult Carcass    14.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.975 Larval Midgut    4062.2 Larval Hindgut    473.1 Larval Malpighian Tubules    1933 Larval Fat Body    15.1 Larval Salivary Gland    5.4 Larval Trachea    7.275 Larval Carcass    7 Adult Head    10.7 Adult Eye    6.5 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    5.1 Adult Crop    10.1 Adult Midgut    4349.4 Adult Hindgut    519.7 Adult Malpighian Tubules    3105.1 Adult Fat Body    10.5 Adult Salivary Gland    11.1 Adult Heart    6.675 Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    6 Adult Ovary    3.2 Adult Testis    7.6 Adult Male Accessory Gland    3 Adult Carcass    14.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    6.5   NA  Brain    2.6   3.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    5.1   NA  Crop    no informative data   4062.2  Midgut    4349.4   473.1  Hindgut    519.7   1933  Malpighian Tubules    3105.1   no informative data  Fat Body    no informative data   5.4  Salivary Gland    no informative data   NA  Heart    6.675   7.275  Trachea    NA   NA  VirginFemale Spermatheca    6.7   NA  InseminatedFemale Spermatheca    6   NA  Ovary    3.2   NA  Testis    7.6   NA  Male Accessory Gland    3   7  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    457 digestive system, 1-day adult    841 digestive system, 4-day adult    403 digestive system, 20-day adult    601 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    13 carcass, 4-day adult    9 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    15 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (51) central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering  (457) digestive system, 1-day adult  (841) digestive system, 4-day adult  (403) digestive system, 20-day adult  (601) fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    13 carcass, 4-day adult    9 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    15 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering  (457) digestive system, 1-day adult  (841) digestive system, 4-day adult  (403) digestive system, 20-day adult  (601) fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    13 carcass, 4-day adult    9 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    15 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    457 digestive system, 1-day adult    841 digestive system, 4-day adult    403 digestive system, 20-day adult    601 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    13 carcass, 4-day adult    9 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    15 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    457 digestive system, 1-day adult    841 digestive system, 4-day adult    403 digestive system, 20-day adult    601 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    13 carcass, 4-day adult    9 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    15 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (51) central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering  (457) digestive system, 1-day adult  (841) digestive system, 4-day adult  (403) digestive system, 20-day adult  (601) fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    13 carcass, 4-day adult    9 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    15 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering  (457) digestive system, 1-day adult  (841) digestive system, 4-day adult  (403) digestive system, 20-day adult  (601) fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    13 carcass, 4-day adult    9 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    15 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    1 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    457 digestive system, 1-day adult    841 digestive system, 4-day adult    403 digestive system, 20-day adult    601 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    13 carcass, 4-day adult    9 carcass, 20-day adult    13 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    15 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed during late larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    53 larva L2    68 larva L3 12hr old    81 larva L3 puffstage 1-2    219 larva L3 puffstage 3-6    127 larva L3 puffstage 7-9    54 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    5 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    32 adult male 01day    57 adult male 05day    78 adult male 30day    75 adult female 01day    75 adult female 05day    64 adult female 30day    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1  (53) larva L2  (68) larva L3 12hr old  (81) larva L3 puffstage 1-2  (219) larva L3 puffstage 3-6  (127) larva L3 puffstage 7-9  (54) white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    5 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP  (32) adult male 01day  (57) adult male 05day  (78) adult male 30day  (75) adult female 01day  (75) adult female 05day  (64) adult female 30day  (71) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    53 larva L2    68 larva L3 12hr old    81 larva L3 puffstage 1-2  (219) larva L3 puffstage 3-6  (127) larva L3 puffstage 7-9    54 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    5 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    32 adult male 01day    57 adult male 05day    78 adult male 30day    75 adult female 01day    75 adult female 05day    64 adult female 30day    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    53 larva L2    68 larva L3 12hr old    81 larva L3 puffstage 1-2    219 larva L3 puffstage 3-6    127 larva L3 puffstage 7-9    54 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    5 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    32 adult male 01day    57 adult male 05day    78 adult male 30day    75 adult female 01day    75 adult female 05day    64 adult female 30day    71 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    53 larva L2    68 larva L3 12hr old    81 larva L3 puffstage 1-2    219 larva L3 puffstage 3-6    127 larva L3 puffstage 7-9    54 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    5 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    32 adult male 01day    57 adult male 05day    78 adult male 30day    75 adult female 01day    75 adult female 05day    64 adult female 30day    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1  (53) larva L2  (68) larva L3 12hr old  (81) larva L3 puffstage 1-2  (219) larva L3 puffstage 3-6  (127) larva L3 puffstage 7-9  (54) white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    5 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP  32 adult male 01day  (57) adult male 05day  (78) adult male 30day  (75) adult female 01day  (75) adult female 05day  (64) adult female 30day  (71) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    53 larva L2    68 larva L3 12hr old    81 larva L3 puffstage 1-2  (219) larva L3 puffstage 3-6  127 larva L3 puffstage 7-9    54 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    5 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    32 adult male 01day    57 adult male 05day    78 adult male 30day    75 adult female 01day    75 adult female 05day    64 adult female 30day    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    53 larva L2    68 larva L3 12hr old    81 larva L3 puffstage 1-2    219 larva L3 puffstage 3-6    127 larva L3 puffstage 7-9    54 white prepupae new    14 white prepupae 12hr    16 white prepupae 24hr    5 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    32 adult male 01day    57 adult male 05day    78 adult male 30day    75 adult female 01day    75 adult female 05day    64 adult female 30day    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    2 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    2 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    2 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    2 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    2 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    2 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    2 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    2 embryonic GM2    2 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    39 heat shock, 4-day adult    115 Cadmium 50 mM 6 hrs, larvae L3    275 Cadmium 50 mM 12 hrs, larvae L3    251 Cadmium 50 mM 48 hrs, 4-day adult    138 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    153 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    117 Zinc 4.5 mM 48 hrs, 4-day adult    51 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    319 Ethanol 10% 3 hrs, larvae L3    224 Caffeine 1.5 mg/ml 4 hrs, larvae L3    260 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    306 Rotenone 8 μg 12 hrs, larvae L3    162 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (31) cold shock, 4-day adult  (39) heat shock, 4-day adult  (115) Cadmium 50 mM 6 hrs, larvae L3  (275) Cadmium 50 mM 12 hrs, larvae L3  (251) Cadmium 50 mM 48 hrs, 4-day adult  (138) Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3  (153) Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3  (117) Zinc 4.5 mM 48 hrs, 4-day adult  (51) Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3  (319) Ethanol 10% 3 hrs, larvae L3  (224) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (260) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult  (30) Paraquat 5 mM 48 hrs, 4-day adult  (36) Paraquat 10 mM 48 hrs, 4-day adult  (57) Rotenone 2 μg 12 hrs, larvae L3  (306) Rotenone 8 μg 12 hrs, larvae L3  (162) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    39 heat shock, 4-day adult  (115) Cadmium 50 mM 6 hrs, larvae L3  (275) Cadmium 50 mM 12 hrs, larvae L3  (251) Cadmium 50 mM 48 hrs, 4-day adult  (138) Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3  (153) Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3  (117) Zinc 4.5 mM 48 hrs, 4-day adult    51 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3  (319) Ethanol 10% 3 hrs, larvae L3  (224) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (260) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3  (306) Rotenone 8 μg 12 hrs, larvae L3  (162) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    39 heat shock, 4-day adult    115 Cadmium 50 mM 6 hrs, larvae L3    275 Cadmium 50 mM 12 hrs, larvae L3    251 Cadmium 50 mM 48 hrs, 4-day adult    138 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    153 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    117 Zinc 4.5 mM 48 hrs, 4-day adult    51 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    319 Ethanol 10% 3 hrs, larvae L3    224 Caffeine 1.5 mg/ml 4 hrs, larvae L3    260 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    306 Rotenone 8 μg 12 hrs, larvae L3    162 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    39 heat shock, 4-day adult    115 Cadmium 50 mM 6 hrs, larvae L3    275 Cadmium 50 mM 12 hrs, larvae L3    251 Cadmium 50 mM 48 hrs, 4-day adult    138 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    153 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    117 Zinc 4.5 mM 48 hrs, 4-day adult    51 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    319 Ethanol 10% 3 hrs, larvae L3    224 Caffeine 1.5 mg/ml 4 hrs, larvae L3    260 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    306 Rotenone 8 μg 12 hrs, larvae L3    162 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  31 cold shock, 4-day adult  (39) heat shock, 4-day adult  (115) Cadmium 50 mM 6 hrs, larvae L3  (275) Cadmium 50 mM 12 hrs, larvae L3  (251) Cadmium 50 mM 48 hrs, 4-day adult  (138) Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3  (153) Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3  (117) Zinc 4.5 mM 48 hrs, 4-day adult  (51) Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3  (319) Ethanol 10% 3 hrs, larvae L3  (224) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (260) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult  30 Paraquat 5 mM 48 hrs, 4-day adult  (36) Paraquat 10 mM 48 hrs, 4-day adult  (57) Rotenone 2 μg 12 hrs, larvae L3  (306) Rotenone 8 μg 12 hrs, larvae L3  (162) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    39 heat shock, 4-day adult  115 Cadmium 50 mM 6 hrs, larvae L3  (275) Cadmium 50 mM 12 hrs, larvae L3  (251) Cadmium 50 mM 48 hrs, 4-day adult  138 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3  (153) Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3  117 Zinc 4.5 mM 48 hrs, 4-day adult    51 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3  (319) Ethanol 10% 3 hrs, larvae L3  (224) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (260) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3  (306) Rotenone 8 μg 12 hrs, larvae L3  (162) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    39 heat shock, 4-day adult    115 Cadmium 50 mM 6 hrs, larvae L3    275 Cadmium 50 mM 12 hrs, larvae L3    251 Cadmium 50 mM 48 hrs, 4-day adult    138 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    153 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    117 Zinc 4.5 mM 48 hrs, 4-day adult    51 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    319 Ethanol 10% 3 hrs, larvae L3    224 Caffeine 1.5 mg/ml 4 hrs, larvae L3    260 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    30 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    306 Rotenone 8 μg 12 hrs, larvae L3    162 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_16 mE1_20_mRNA_expression_cluster_16
External Data & Images
Linkouts	BDGP expression data • GH17088 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030688 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8952-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG8952GD6317 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG8952 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG8952 Class Mutagen Stocks Known lesion CG8952GD6317 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG8952NIG.8952R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6250 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6317} NA P{NIG.8952R} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
endopeptidase activity non-traceable author statement (Ross et al., 2003) serine-type endopeptidase activity inferred from sequence or structural similarity with EMBL:AY190633 (FlyBase, 1992-)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 (FlyBase Curators et al., 2004-) non-traceable author statement (Ross et al., 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG8952 - FK506-bp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8952 - Nlp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8952 - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8952 - smt3 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG8952 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030688 DroID - A comprehensive database of gene and protein interactions. • FBgn0030688 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32525
Orthologs
OrthoDB Orthologs (233) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6X3HMK Dipteran inclusive ortholog search EOG66MBTH Insect inclusive ortholog search EOG6NVXG9 Arthropod inclusive ortholog search EOG673N7R Metazoa inclusive ortholog search EOG6NKQP1
Orthologs in Drosophila Species (EOG6X3HMK)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG8952     Drosophila simulans   Dsim\GD15779 Y   Drosophila sechellia   Dsec\GM22528 Y   Drosophila erecta   Dere\GG19374 Y   Drosophila yakuba   Dyak\GE16022 Y   Drosophila ananassae   Dana\GF11464 Y   Drosophila willistoni   Dwil\GK19756 Y   Drosophila virilis   Dvir\GJ15994 Y   Drosophila mojavensis   Dmoj\GI21521 Y   Drosophila grimshawi   Dgri\GH23851     Drosophila grimshawi   Dgri\GH24189 Y
Orthologs in non-Drosophila Dipterans (EOG66MBTH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006902   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009689   Anopheles gambiae Malaria mosquito  Agam\AGAP010240   Anopheles gambiae Malaria mosquito  Agam\AGAP004741   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019165   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003826   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016012
Orthologs in non-Dipteran Insects (EOG6NVXG9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010362 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011433 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB13645 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012777 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008515 Y Bombyx mori Silkmoth  Bmor\BGIBMGA009527 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014431 Y Bombyx mori Silkmoth  Bmor\BGIBMGA009528 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014428 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010584 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012791 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014427 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014022 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008514 Y Bombyx mori Silkmoth  Bmor\Bmo.13383 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014524 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007377 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008513 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014430 Y Bombyx mori Silkmoth  Bmor\BGIBMGA009526 Y Pediculus humanus Human body louse  Phum\PHUM505030 Y Tribolium castaneum Red flour beetle  Tcas\P38 Y Tribolium castaneum Red flour beetle  Tcas\H118 Y Tribolium castaneum Red flour beetle  Tcas\H130 Y Tribolium castaneum Red flour beetle  Tcas\H112 Y Tribolium castaneum Red flour beetle  Tcas\H116 Y Tribolium castaneum Red flour beetle  Tcas\H122 Y Tribolium castaneum Red flour beetle  Tcas\TC010911 Y Tribolium castaneum Red flour beetle  Tcas\P96 Y Tribolium castaneum Red flour beetle  Tcas\P160 Y Tribolium castaneum Red flour beetle  Tcas\H115 Y Tribolium castaneum Red flour beetle  Tcas\H101 Y Tribolium castaneum Red flour beetle  Tcas\P165 Y Tribolium castaneum Red flour beetle  Tcas\H105 Y Tribolium castaneum Red flour beetle  Tcas\TC006246 Y Tribolium castaneum Red flour beetle  Tcas\P37 Y Tribolium castaneum Red flour beetle  Tcas\P149 Y Tribolium castaneum Red flour beetle  Tcas\P154 Y Tribolium castaneum Red flour beetle  Tcas\H143 Y Tribolium castaneum Red flour beetle  Tcas\H108 Y Tribolium castaneum Red flour beetle  Tcas\h102 Y Tribolium castaneum Red flour beetle  Tcas\yip7 Y Tribolium castaneum Red flour beetle  Tcas\P150 Y Tribolium castaneum Red flour beetle  Tcas\H104 Y Tribolium castaneum Red flour beetle  Tcas\P127 Y Tribolium castaneum Red flour beetle  Tcas\H113 Y Tribolium castaneum Red flour beetle  Tcas\TC010908 Y Tribolium castaneum Red flour beetle  Tcas\H111 Y Tribolium castaneum Red flour beetle  Tcas\H120 Y Tribolium castaneum Red flour beetle  Tcas\H152 Y Tribolium castaneum Red flour beetle  Tcas\P167 Y Tribolium castaneum Red flour beetle  Tcas\H107 Y Tribolium castaneum Red flour beetle  Tcas\P123 Y Tribolium castaneum Red flour beetle  Tcas\H110 Y Tribolium castaneum Red flour beetle  Tcas\P121 Y Tribolium castaneum Red flour beetle  Tcas\H148 Y Tribolium castaneum Red flour beetle  Tcas\P161 Y Tribolium castaneum Red flour beetle  Tcas\H114 Y Tribolium castaneum Red flour beetle  Tcas\H64 Y Tribolium castaneum Red flour beetle  Tcas\H132 Y Tribolium castaneum Red flour beetle  Tcas\H131 Y Tribolium castaneum Red flour beetle  Tcas\H119 Y Tribolium castaneum Red flour beetle  Tcas\h103 Y Tribolium castaneum Red flour beetle  Tcas\TC006247 Y Tribolium castaneum Red flour beetle  Tcas\P128 Y Tribolium castaneum Red flour beetle  Tcas\P166 Y
Orthologs in non-Insect Arthropods (EOG673N7R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\MT-CYB Y Daphnia pulex Water flea  Dpux\CHY1H Y Daphnia pulex Water flea  Dpux\CHY1 Y Daphnia pulex Water flea  Dpux\JGI_V11_347753 Y Daphnia pulex Water flea  Dpux\CHY1A Y Daphnia pulex Water flea  Dpux\JGI_V11_347750 Y Daphnia pulex Water flea  Dpux\RPB2D Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\rbcL Y Daphnia pulex Water flea  Dpux\JGI_V11_195659 Y Daphnia pulex Water flea  Dpux\JGI_V11_230174 Y Daphnia pulex Water flea  Dpux\matK Y Daphnia pulex Water flea  Dpux\JGI_V11_347783 Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\31.2 Y Daphnia pulex Water flea  Dpux\JGI_V11_316896 Y Daphnia pulex Water flea  Dpux\JGI_V11_332389 Y Daphnia pulex Water flea  Dpux\JGI_V11_100270 Y Daphnia pulex Water flea  Dpux\CO1 Y Daphnia pulex Water flea  Dpux\cytb Y Daphnia pulex Water flea  Dpux\CHY1C Y Daphnia pulex Water flea  Dpux\rec Y
Orthologs in non-Arthropod Metazoa (EOG6NKQP1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\try-4 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016868gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010750gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025575gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020315gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005427gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010205gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026191gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000377gn Y Danio rerio Zebrafish  Drer\ENSDARG00000043173 Y Danio rerio Zebrafish  Drer\ela2 Y Danio rerio Zebrafish  Drer\zgc:112285 Y Danio rerio Zebrafish  Drer\ENSDARG00000010378 Y Danio rerio Zebrafish  Drer\f9b Y Danio rerio Zebrafish  Drer\zgc:112368 Y Danio rerio Zebrafish  Drer\si:dkey-57c15.4 Y Danio rerio Zebrafish  Drer\ENSDARG00000068726 Y Danio rerio Zebrafish  Drer\masp2 Y Danio rerio Zebrafish  Drer\f7 Y Danio rerio Zebrafish  Drer\LOC562139 Y Danio rerio Zebrafish  Drer\zgc:154142 Y Danio rerio Zebrafish  Drer\ENSDARG00000075719 Y Danio rerio Zebrafish  Drer\CR944667.3 Y Danio rerio Zebrafish  Drer\si:dkey-33i11.3 Y Danio rerio Zebrafish  Drer\ENSDARG00000017314 Y Danio rerio Zebrafish  Drer\DKEY-33I11.3 Y Danio rerio Zebrafish  Drer\ela3l Y Danio rerio Zebrafish  Drer\ENSDARG00000076045 Y Danio rerio Zebrafish  Drer\f10 Y Danio rerio Zebrafish  Drer\zgc:92511 Y Danio rerio Zebrafish  Drer\ENSDARG00000089722 Y Danio rerio Zebrafish  Drer\ctrb1 Y Danio rerio Zebrafish  Drer\ela2l Y Danio rerio Zebrafish  Drer\f9a Y Danio rerio Zebrafish  Drer\ENSDARG00000011144 Y Danio rerio Zebrafish  Drer\zgc:112160 Y Danio rerio Zebrafish  Drer\f7i Y Danio rerio Zebrafish  Drer\ctrl Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033013 Y Xenopus tropicalis Western clawed frog  Xtro\tmprss12 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000023914 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000025253 Y Xenopus tropicalis Western clawed frog  Xtro\cela3b Y Xenopus tropicalis Western clawed frog  Xtro\c1s Y Xenopus tropicalis Western clawed frog  Xtro\cela3a Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033599 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000014195 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033339 Y Xenopus tropicalis Western clawed frog  Xtro\f9 Y Xenopus tropicalis Western clawed frog  Xtro\f10 Y Xenopus tropicalis Western clawed frog  Xtro\gprin3 Y Xenopus tropicalis Western clawed frog  Xtro\ctrb1 Y Xenopus tropicalis Western clawed frog  Xtro\cela2a Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032160 Y Xenopus tropicalis Western clawed frog  Xtro\masp1 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000025157 Y Xenopus tropicalis Western clawed frog  Xtro\hpn Y Xenopus tropicalis Western clawed frog  Xtro\masp2 Y Xenopus tropicalis Western clawed frog  Xtro\c1r Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033050 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000014270 Y Xenopus tropicalis Western clawed frog  Xtro\ctrb2 Y Gallus gallus Domestic chicken  Ggal\LOC431235 Y Gallus gallus Domestic chicken  Ggal\C1R Y Gallus gallus Domestic chicken  Ggal\LOC771012 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000004866 Y Gallus gallus Domestic chicken  Ggal\MASP1 Y Gallus gallus Domestic chicken  Ggal\F9 Y Gallus gallus Domestic chicken  Ggal\CELA2A Y Gallus gallus Domestic chicken  Ggal\CTRL Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000006081 Y Gallus gallus Domestic chicken  Ggal\C1S Y Gallus gallus Domestic chicken  Ggal\CTRC Y Gallus gallus Domestic chicken  Ggal\MASP2 Y Mus musculus House mouse  Mmus\C1rl Y Mus musculus House mouse  Mmus\Cela3b Y Mus musculus House mouse  Mmus\Ctrl Y Mus musculus House mouse  Mmus\F9 Y Mus musculus House mouse  Mmus\Hpn Y Mus musculus House mouse  Mmus\Gm13011 Y Mus musculus House mouse  Mmus\Klk15 Y Mus musculus House mouse  Mmus\Cela1 Y Mus musculus House mouse  Mmus\Klk1b22 Y Mus musculus House mouse  Mmus\F10 Y Mus musculus House mouse  Mmus\Gm5077 Y Mus musculus House mouse  Mmus\C1s Y Mus musculus House mouse  Mmus\Cela2a Y Mus musculus House mouse  Mmus\Ctrb1 Y Mus musculus House mouse  Mmus\Tmprss12 Y Mus musculus House mouse  Mmus\C1ra Y Mus musculus House mouse  Mmus\Masp2 Y Mus musculus House mouse  Mmus\C1rb Y Mus musculus House mouse  Mmus\Masp1 Y Rattus norvegicus Norway rat  Rnor\Ctrl Y Rattus norvegicus Norway rat  Rnor\Ctrb1 Y Rattus norvegicus Norway rat  Rnor\Masp2 Y Rattus norvegicus Norway rat  Rnor\Klk15 Y Rattus norvegicus Norway rat  Rnor\Cela3b Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000003430 Y Rattus norvegicus Norway rat  Rnor\F10 Y Rattus norvegicus Norway rat  Rnor\LOC100362912 Y Rattus norvegicus Norway rat  Rnor\C1r Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000004725 Y Rattus norvegicus Norway rat  Rnor\Cela2a Y Rattus norvegicus Norway rat  Rnor\C1rl Y Rattus norvegicus Norway rat  Rnor\Ctrc Y Rattus norvegicus Norway rat  Rnor\C1s Y Rattus norvegicus Norway rat  Rnor\Masp1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000021097 Y Homo sapiens Human  Hsap\CELA3B Y Homo sapiens Human  Hsap\TMPRSS12 Y Homo sapiens Human  Hsap\MASP1 Y Homo sapiens Human  Hsap\CELA3A Y Homo sapiens Human  Hsap\ENSG00000168925 Y Homo sapiens Human  Hsap\CELA1 Y Homo sapiens Human  Hsap\ELA2A Y Homo sapiens Human  Hsap\CTRL Y Homo sapiens Human  Hsap\KLK15 Y Homo sapiens Human  Hsap\F10 Y Homo sapiens Human  Hsap\CTRB2 Y Homo sapiens Human  Hsap\ENSG00000159403 Y Homo sapiens Human  Hsap\CELA2B Y Homo sapiens Human  Hsap\CTRC Y Homo sapiens Human  Hsap\FIX F9 Y Homo sapiens Human  Hsap\MASP2 Y Homo sapiens Human  Hsap\C1S Y Homo sapiens Human  Hsap\HPN Y
Human Orthologs (18)
Gene OMIM HGNC Hsap\CELA3B     Hsap\TMPRSS12     Hsap\MASP1     Hsap\CELA3A     Hsap\ENSG00000168925     Hsap\CELA1     Hsap\ELA2A     Hsap\CTRL     Hsap\KLK15     Hsap\F10     Hsap\CTRB2     Hsap\ENSG00000159403     Hsap\CELA2B     Hsap\CTRC     Hsap\FIX F9     Hsap\MASP2     Hsap\C1S     Hsap\HPN
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15779 Drosophila sechellia Dsec\GM22528 Drosophila erecta Dere\GG19374 Drosophila yakuba Dyak\GE16022 Drosophila ananassae Dana\GF11464 Drosophila willistoni Dwil\GK19756 Drosophila virilis Dvir\GJ15994 Drosophila mojavensis Dmoj\GI21521 Drosophila grimshawi Dgri\GH24189
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v14835 w1118 P{GD6317}v14835
Genomic Clones ( 2 )
	BACR22H11 BACR25C18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 14 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH17088
Other clones	DPiM_GH17088
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH17349
Other clones	214383.38 CK01.17B.F6 CK01.108B.D8 EC051077 EC052595 EC054075 EC054579 EC055772 EC056484 EC056604 EP17355
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030688 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32525
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132844 RefSeq (Proteins) • NP_573072 DDBJ / EMBL / GenBank • AAF48510 AAL28271 AI386815 AW940648 AY060723 Entrez Gene - A searchable database of RefSeq genes. • 32525 UniProtKB/TrEMBL • Q7K2R3 Q9VXP8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S1 (IPR001254) Peptidase S1A, chymotrypsin-type (IPR001314) Trypsin-like cysteine/serine peptidase domain (IPR009003) Peptidase S1, trypsin family, active site (IPR018114) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH17088
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030688 DroID - A comprehensive database of gene and protein interactions. • FBgn0030688 DRSC - Results from RNAi screens. • FBgn0030688 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030688 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8952-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030688 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32525 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32525 modMine - Data generated by the modENCODE project. • FBgn0030688
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG8952 (Wittkopp et al., 2006, Wittkopp et al., 2008, Japanese National Institute of Genetics, 2012.5.21) SP52 (Ross et al., 2003)
Name Synonym
Secondary FlyBase IDs
References ( 17 )
Research paper	Wittkopp et al., 2006, Genetics 173(3): 1817--1821 Parent-of-origin effects on mRNA expression in Drosophila melanogaster not caused by genomic imprinting. [FBrf0195393] McGraw et al., 2004, Curr. Biol. 14(16): 1509--1514 Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster. [FBrf0180059] Ross et al., 2003, Gene 304(1-2): 117--131 Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. [FBrf0155784]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Wittkopp et al., 2008, Nat. Genet. 40(3): Supplementary Information [FBrf0208881]
Personal communication to FlyBase	Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Curated genome annotation	Gong, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126669]