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Gene Dmel\CG8974

General Information
Symbol	Dmel\CG8974	Species	D. melanogaster
Name		Annotation symbol	CG8974
Feature type	protein_coding_gene	FlyBase ID	FBgn0030693
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	13E18-13F1	Sequence location	X:15,687,752..15,690,082 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG8974 (FBgn0030693). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Zinc finger, C3HC4 RING-type; Zinc finger, RING-type; Zinc finger, RING-type, conserved site; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634577_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of CG8974. Gene sequence location is X:15687752..15690082.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN40062
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 13E18-13F1   Limits computationally determined from genome sequence between P{EP}EP1489 and P{EP}BEST:RE35685EP1581&P{EP}sdEP1088
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG8974 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG8974-RA FBtr0074186  NM_167462   1495   277 CG8974-RB FBtr0074187  NM_167463   1416   277 CG8974-RC FBtr0074185  NM_132848   1761   277 CG8974-RD FBtr0074188  NM_206726   1303   277 CG8974-RE FBtr0074189  NM_206725   1340   277
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG8974-PA   FBpp0073971   30.4   277   5.69     NP_727896   AAG22355 CG8974-PB   FBpp0073972   30.4   277   5.69     NP_727897   AAG22354 CG8974-PC   FBpp0073970   30.4   277   5.69     NP_573076   AAF48517 CG8974-PD   FBpp0073973   30.4   277   5.69     NP_996449   AAS65349 CG8974-PE   FBpp0073974   30.4   277   5.69     NP_996448   AAS65350
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, RING-type (IPR001841) Zinc finger, RING-type, conserved site (IPR017907) Zinc finger, C3HC4 RING-type (IPR018957) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441491   AA735392   AA803364   AE014298 AAF48517   AE014298 AAG22354   AE014298 AAG22355   AE014298 AAS65349   AE014298 AAS65350   AI113991   AI114034   AI135534   AI238039   AI238069   AI259101   AI402317   AI403049   AI512634   AI513288   AI520195   AI946180   AY060297 AAL25336   BE978135   BG641446   BI162242   BI162243   BI167597   BI170213   BI170757   BI172409   BI240122   BI241839   BI354864   BI364635   BI370659   BI370887   BI482857   BI575063   BI585928   BI620353   BI639362   BI641134   BP547859   BP560229   BP560230   BT082041   CA804469   CO188492   CO194211   CO263502   CO268468   CO270846   CO278805   CO286618   CO307596   CO317942   CO318189   CO324618   CO324942   CO327408   CO327771   CO327785   CO329386   CO342500   CO342590   CO344374   CZ490126   EC058062   EC059045   EC070848   EC074824   EC078178   EC080134   EC082230   EC087862   EC200470   EC200885   EC214906   EC216171   EC219614   EC219615   EC220202   EC221372   EC229702   EC238735   EC240058   EC251997   EC256057   EC257464   EC258048   EC260255   EC260510   EL872931   EL872932   EL884369   EL884370   EV575277   EV580188   GH759852   GH780518   GH785679   GH802489   GH805127   GH811651   GH817721   GH818074   GH819649   GH828161   GH829663   GH829743   GH831021   GH834810   GH845223   GH856864   GH858923   GH877778   GH886397   GH893185   GH917465   GH924963   GH925648   GH926565   GH931316   GH931985   GH933547   GH938156
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VXP1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030693    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030693 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030693 expression level Developmental Stage   Expression Level embryo 00-02hr    1388 embryo 02-04hr    1989 embryo 04-06hr    1210 embryo 06-08hr    1197 embryo 08-10hr    1716 embryo 10-12hr    1728 embryo 12-14hr    1881 embryo 14-16hr    1064 embryo 16-18hr    1518 embryo 18-20hr    1380 embryo 20-22hr    1641 embryo 22-24hr    2144 larva L1    1140 larva L2    1100 larva L3 12hr old    1128 larva L3 puffstage 1-2    1617 larva L3 puffstage 3-6    1687 larva L3 puffstage 7-9    2498 white prepupae new    2056 white prepupae 12hr    2487 white prepupae 24hr    1969 pupae 2d postWPP    1851 pupae 3d postWPP    1709 pupae 4d postWPP    1341 adult male 01day    1844 adult male 05day    2388 adult male 30day    1479 adult female 01day    1048 adult female 05day    1630 adult female 30day    1666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1388) embryo 02-04hr  (1989) embryo 04-06hr  (1210) embryo 06-08hr  (1197) embryo 08-10hr  (1716) embryo 10-12hr  (1728) embryo 12-14hr  (1881) embryo 14-16hr  (1064) embryo 16-18hr  (1518) embryo 18-20hr  (1380) embryo 20-22hr  (1641) embryo 22-24hr  (2144) larva L1  (1140) larva L2  (1100) larva L3 12hr old  (1128) larva L3 puffstage 1-2  (1617) larva L3 puffstage 3-6  (1687) larva L3 puffstage 7-9  (2498) white prepupae new  (2056) white prepupae 12hr  (2487) white prepupae 24hr  (1969) pupae 2d postWPP  (1851) pupae 3d postWPP  (1709) pupae 4d postWPP  (1341) adult male 01day  (1844) adult male 05day  (2388) adult male 30day  (1479) adult female 01day  (1048) adult female 05day  (1630) adult female 30day  (1666) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1388 embryo 02-04hr  (1989) embryo 04-06hr    1210 embryo 06-08hr    1197 embryo 08-10hr  (1716) embryo 10-12hr  (1728) embryo 12-14hr  (1881) embryo 14-16hr    1064 embryo 16-18hr  (1518) embryo 18-20hr    1380 embryo 20-22hr  (1641) embryo 22-24hr  (2144) larva L1    1140 larva L2    1100 larva L3 12hr old    1128 larva L3 puffstage 1-2  (1617) larva L3 puffstage 3-6  (1687) larva L3 puffstage 7-9  (2498) white prepupae new  (2056) white prepupae 12hr  (2487) white prepupae 24hr  (1969) pupae 2d postWPP  (1851) pupae 3d postWPP  (1709) pupae 4d postWPP    1341 adult male 01day  (1844) adult male 05day  (2388) adult male 30day  1479 adult female 01day    1048 adult female 05day  (1630) adult female 30day  (1666) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1388 embryo 02-04hr    1989 embryo 04-06hr    1210 embryo 06-08hr    1197 embryo 08-10hr    1716 embryo 10-12hr    1728 embryo 12-14hr    1881 embryo 14-16hr    1064 embryo 16-18hr    1518 embryo 18-20hr    1380 embryo 20-22hr    1641 embryo 22-24hr    2144 larva L1    1140 larva L2    1100 larva L3 12hr old    1128 larva L3 puffstage 1-2    1617 larva L3 puffstage 3-6    1687 larva L3 puffstage 7-9    2498 white prepupae new    2056 white prepupae 12hr    2487 white prepupae 24hr    1969 pupae 2d postWPP    1851 pupae 3d postWPP    1709 pupae 4d postWPP    1341 adult male 01day    1844 adult male 05day    2388 adult male 30day    1479 adult female 01day    1048 adult female 05day    1630 adult female 30day    1666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1388 embryo 02-04hr    1989 embryo 04-06hr    1210 embryo 06-08hr    1197 embryo 08-10hr    1716 embryo 10-12hr    1728 embryo 12-14hr    1881 embryo 14-16hr    1064 embryo 16-18hr    1518 embryo 18-20hr    1380 embryo 20-22hr    1641 embryo 22-24hr    2144 larva L1    1140 larva L2    1100 larva L3 12hr old    1128 larva L3 puffstage 1-2    1617 larva L3 puffstage 3-6    1687 larva L3 puffstage 7-9    2498 white prepupae new    2056 white prepupae 12hr    2487 white prepupae 24hr    1969 pupae 2d postWPP    1851 pupae 3d postWPP    1709 pupae 4d postWPP    1341 adult male 01day    1844 adult male 05day    2388 adult male 30day    1479 adult female 01day    1048 adult female 05day    1630 adult female 30day    1666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030693 expression level Developmental Stage   Expression Level embryo 00-02hr    1388 embryo 02-04hr    1989 embryo 04-06hr    1210 embryo 06-08hr    1197 embryo 08-10hr    1716 embryo 10-12hr    1728 embryo 12-14hr    1881 embryo 14-16hr    1064 embryo 16-18hr    1518 embryo 18-20hr    1380 embryo 20-22hr    1641 embryo 22-24hr    2144 larva L1    1140 larva L2    1100 larva L3 12hr old    1128 larva L3 puffstage 1-2    1617 larva L3 puffstage 3-6    1687 larva L3 puffstage 7-9    2498 white prepupae new    2056 white prepupae 12hr    2487 white prepupae 24hr    1969 pupae 2d postWPP    1851 pupae 3d postWPP    1709 pupae 4d postWPP    1341 adult male 01day    1844 adult male 05day    2388 adult male 30day    1479 adult female 01day    1048 adult female 05day    1630 adult female 30day    1666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1388) embryo 02-04hr  (1989) embryo 04-06hr  (1210) embryo 06-08hr  (1197) embryo 08-10hr  (1716) embryo 10-12hr  (1728) embryo 12-14hr  (1881) embryo 14-16hr  (1064) embryo 16-18hr  (1518) embryo 18-20hr  (1380) embryo 20-22hr  (1641) embryo 22-24hr  (2144) larva L1  (1140) larva L2  (1100) larva L3 12hr old  (1128) larva L3 puffstage 1-2  (1617) larva L3 puffstage 3-6  (1687) larva L3 puffstage 7-9  (2498) white prepupae new  (2056) white prepupae 12hr  (2487) white prepupae 24hr  (1969) pupae 2d postWPP  (1851) pupae 3d postWPP  (1709) pupae 4d postWPP  (1341) adult male 01day  (1844) adult male 05day  (2388) adult male 30day  (1479) adult female 01day  (1048) adult female 05day  (1630) adult female 30day  (1666) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1388 embryo 02-04hr  1989 embryo 04-06hr    1210 embryo 06-08hr    1197 embryo 08-10hr  1716 embryo 10-12hr  1728 embryo 12-14hr  1881 embryo 14-16hr    1064 embryo 16-18hr  1518 embryo 18-20hr    1380 embryo 20-22hr  1641 embryo 22-24hr  2144 larva L1    1140 larva L2    1100 larva L3 12hr old    1128 larva L3 puffstage 1-2  1617 larva L3 puffstage 3-6  1687 larva L3 puffstage 7-9  (2498) white prepupae new  2056 white prepupae 12hr  (2487) white prepupae 24hr  1969 pupae 2d postWPP  1851 pupae 3d postWPP  1709 pupae 4d postWPP    1341 adult male 01day  1844 adult male 05day  2388 adult male 30day  1479 adult female 01day    1048 adult female 05day  1630 adult female 30day  1666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1388 embryo 02-04hr    1989 embryo 04-06hr    1210 embryo 06-08hr    1197 embryo 08-10hr    1716 embryo 10-12hr    1728 embryo 12-14hr    1881 embryo 14-16hr    1064 embryo 16-18hr    1518 embryo 18-20hr    1380 embryo 20-22hr    1641 embryo 22-24hr    2144 larva L1    1140 larva L2    1100 larva L3 12hr old    1128 larva L3 puffstage 1-2    1617 larva L3 puffstage 3-6    1687 larva L3 puffstage 7-9    2498 white prepupae new    2056 white prepupae 12hr    2487 white prepupae 24hr    1969 pupae 2d postWPP    1851 pupae 3d postWPP    1709 pupae 4d postWPP    1341 adult male 01day    1844 adult male 05day    2388 adult male 30day    1479 adult female 01day    1048 adult female 05day    1630 adult female 30day    1666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1388 embryo 02-04hr    1989 embryo 04-06hr    1210 embryo 06-08hr    1197 embryo 08-10hr    1716 embryo 10-12hr    1728 embryo 12-14hr    1881 embryo 14-16hr    1064 embryo 16-18hr    1518 embryo 18-20hr    1380 embryo 20-22hr    1641 embryo 22-24hr    2144 larva L1    1140 larva L2    1100 larva L3 12hr old    1128 larva L3 puffstage 1-2    1617 larva L3 puffstage 3-6    1687 larva L3 puffstage 7-9    2498 white prepupae new    2056 white prepupae 12hr    2487 white prepupae 24hr    1969 pupae 2d postWPP    1851 pupae 3d postWPP    1709 pupae 4d postWPP    1341 adult male 01day    1844 adult male 05day    2388 adult male 30day    1479 adult female 01day    1048 adult female 05day    1630 adult female 30day    1666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030693    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030693 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030693 expression level Tissue   Expression Level Larval Central Nervous System    756.825 Larval Midgut    1074.4 Larval Hindgut    1250.3 Larval Malpighian Tubules    1391.4 Larval Fat Body    1213.2 Larval Salivary Gland    1543.4 Larval Trachea    1254.65 Larval Carcass    828.3 Adult Head    1304.5 Adult Eye    2981.4 Adult Brain    764.4 Adult Thoracic-Abdominal Ganglion    812.8 Adult Crop    1994.2 Adult Midgut    1099.4 Adult Hindgut    1597.5 Adult Malpighian Tubules    1542.1 Adult Fat Body    1460.1 Adult Salivary Gland    2866.2 Adult Heart    1589.625 Adult VirginFemale Spermatheca    1453.5 Adult InseminatedFemale Spermatheca    1484.4 Adult Ovary    595.9 Adult Testis    670.1 Adult Male Accessory Gland    1296.2 Adult Carcass    1024.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (756.825) Larval Midgut  (1074.4) Larval Hindgut  (1250.3) Larval Malpighian Tubules  (1391.4) Larval Fat Body  (1213.2) Larval Salivary Gland  (1543.4) Larval Trachea  (1254.65) Larval Carcass  (828.3) Adult Head  (1304.5) Adult Eye  (2981.4) Adult Brain  (764.4) Adult Thoracic-Abdominal Ganglion  (812.8) Adult Crop  (1994.2) Adult Midgut  (1099.4) Adult Hindgut  (1597.5) Adult Malpighian Tubules  (1542.1) Adult Fat Body  (1460.1) Adult Salivary Gland  (2866.2) Adult Heart  (1589.625) Adult VirginFemale Spermatheca  (1453.5) Adult InseminatedFemale Spermatheca  (1484.4) Adult Ovary  (595.9) Adult Testis  (670.1) Adult Male Accessory Gland  (1296.2) Adult Carcass  (1024.8) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    756.825 Larval Midgut  1074.4 Larval Hindgut  (1250.3) Larval Malpighian Tubules  (1391.4) Larval Fat Body  (1213.2) Larval Salivary Gland  (1543.4) Larval Trachea  (1254.65) Larval Carcass    828.3 Adult Head  (1304.5) Adult Eye  (2981.4) Adult Brain    764.4 Adult Thoracic-Abdominal Ganglion    812.8 Adult Crop  (1994.2) Adult Midgut  (1099.4) Adult Hindgut  (1597.5) Adult Malpighian Tubules  (1542.1) Adult Fat Body  (1460.1) Adult Salivary Gland  (2866.2) Adult Heart  (1589.625) Adult VirginFemale Spermatheca  (1453.5) Adult InseminatedFemale Spermatheca  (1484.4) Adult Ovary    595.9 Adult Testis    670.1 Adult Male Accessory Gland  (1296.2) Adult Carcass  1024.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    756.825 Larval Midgut    1074.4 Larval Hindgut    1250.3 Larval Malpighian Tubules    1391.4 Larval Fat Body    1213.2 Larval Salivary Gland    1543.4 Larval Trachea    1254.65 Larval Carcass    828.3 Adult Head    1304.5 Adult Eye    2981.4 Adult Brain    764.4 Adult Thoracic-Abdominal Ganglion    812.8 Adult Crop    1994.2 Adult Midgut    1099.4 Adult Hindgut    1597.5 Adult Malpighian Tubules    1542.1 Adult Fat Body    1460.1 Adult Salivary Gland    2866.2 Adult Heart    1589.625 Adult VirginFemale Spermatheca    1453.5 Adult InseminatedFemale Spermatheca    1484.4 Adult Ovary    595.9 Adult Testis    670.1 Adult Male Accessory Gland    1296.2 Adult Carcass    1024.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030693 expression level Tissue   Expression Level Larval Central Nervous System    756.825 Larval Midgut    1074.4 Larval Hindgut    1250.3 Larval Malpighian Tubules    1391.4 Larval Fat Body    1213.2 Larval Salivary Gland    1543.4 Larval Trachea    1254.65 Larval Carcass    828.3 Adult Head    1304.5 Adult Eye    2981.4 Adult Brain    764.4 Adult Thoracic-Abdominal Ganglion    812.8 Adult Crop    1994.2 Adult Midgut    1099.4 Adult Hindgut    1597.5 Adult Malpighian Tubules    1542.1 Adult Fat Body    1460.1 Adult Salivary Gland    2866.2 Adult Heart    1589.625 Adult VirginFemale Spermatheca    1453.5 Adult InseminatedFemale Spermatheca    1484.4 Adult Ovary    595.9 Adult Testis    670.1 Adult Male Accessory Gland    1296.2 Adult Carcass    1024.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  756.825 Larval Midgut  (1074.4) Larval Hindgut  (1250.3) Larval Malpighian Tubules  (1391.4) Larval Fat Body  (1213.2) Larval Salivary Gland  (1543.4) Larval Trachea  (1254.65) Larval Carcass  (828.3) Adult Head  (1304.5) Adult Eye  (2981.4) Adult Brain  764.4 Adult Thoracic-Abdominal Ganglion  812.8 Adult Crop  (1994.2) Adult Midgut  (1099.4) Adult Hindgut  (1597.5) Adult Malpighian Tubules  (1542.1) Adult Fat Body  (1460.1) Adult Salivary Gland  (2866.2) Adult Heart  (1589.625) Adult VirginFemale Spermatheca  (1453.5) Adult InseminatedFemale Spermatheca  (1484.4) Adult Ovary  595.9 Adult Testis  670.1 Adult Male Accessory Gland  (1296.2) Adult Carcass  (1024.8) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    756.825 Larval Midgut  1074.4 Larval Hindgut  1250.3 Larval Malpighian Tubules  1391.4 Larval Fat Body  1213.2 Larval Salivary Gland  1543.4 Larval Trachea  1254.65 Larval Carcass    828.3 Adult Head  1304.5 Adult Eye  (2981.4) Adult Brain    764.4 Adult Thoracic-Abdominal Ganglion    812.8 Adult Crop  (1994.2) Adult Midgut  1099.4 Adult Hindgut  1597.5 Adult Malpighian Tubules  1542.1 Adult Fat Body  1460.1 Adult Salivary Gland  (2866.2) Adult Heart  1589.625 Adult VirginFemale Spermatheca  1453.5 Adult InseminatedFemale Spermatheca  1484.4 Adult Ovary    595.9 Adult Testis    670.1 Adult Male Accessory Gland  1296.2 Adult Carcass  1024.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    756.825 Larval Midgut    1074.4 Larval Hindgut    1250.3 Larval Malpighian Tubules    1391.4 Larval Fat Body    1213.2 Larval Salivary Gland    1543.4 Larval Trachea    1254.65 Larval Carcass    828.3 Adult Head    1304.5 Adult Eye    2981.4 Adult Brain    764.4 Adult Thoracic-Abdominal Ganglion    812.8 Adult Crop    1994.2 Adult Midgut    1099.4 Adult Hindgut    1597.5 Adult Malpighian Tubules    1542.1 Adult Fat Body    1460.1 Adult Salivary Gland    2866.2 Adult Heart    1589.625 Adult VirginFemale Spermatheca    1453.5 Adult InseminatedFemale Spermatheca    1484.4 Adult Ovary    595.9 Adult Testis    670.1 Adult Male Accessory Gland    1296.2 Adult Carcass    1024.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1304.5   NA  Eye    2981.4   NA  Brain    764.4   756.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    812.8   NA  Crop    1994.2   1074.4  Midgut    1099.4   1250.3  Hindgut    1597.5   1391.4  Malpighian Tubules    1542.1   1213.2  Fat Body    1460.1   1543.4  Salivary Gland    2866.2   NA  Heart    1589.625   1254.65  Trachea    NA   NA  VirginFemale Spermatheca    1453.5   NA  InseminatedFemale Spermatheca    1484.4   NA  Ovary    595.9   NA  Testis    670.1   NA  Male Accessory Gland    1296.2   828.3  Carcass    1024.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030693 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32581-RA;CG8974-RC FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG8974 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG8974 Class Mutagen Stocks Known lesion CG8974f07310 piggyBac transposase 1 -- CG8974G757 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG8974 Class Mutagen Stocks Known lesion CG8974KK114846 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6250 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK114846} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}CG8974f07310 NA insertion of mobile activating element P{EP}CG8974G757 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR001841 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG8974 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58880 DroID - A comprehensive database of gene and protein interactions. • FBgn0030693 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32532
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19745 Dere\GG19371 Dgri\GH12208 Dmoj\GI15740 Dper\GL14111 Dpse\GA28677 Dsec\GM22525 Dsim\GD15775 Dvir\GJ18601 Dwil\GK25237 Dyak\GE16019
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006550-PA Aedes aegypti (mosquito) AGAP006041-PA Anopheles gambiae (mosquito) XP_392285.1 Apis mellifera (honey bee) XP_001947943.1 Acyrthosiphon pisum (pea aphid) XP_001950503.1 Acyrthosiphon pisum (pea aphid) At2g23780.1 Arabidopsis thaliana (wall cress) 86096 Batrachochytrium dendrobatidis (chytrid fungus) 141138 Branchiostoma floridae (lancelet) 141161 Branchiostoma floridae (lancelet) XP_001902780.1 Brugia malayi (roundworm nematode) BGIBMGA002862-PA Bombyx mori (silk worm) ENSBTAP00000003661 Bos taurus (bovine) CBP19809 Caenorhabditis briggsae (nematode) CE01498 Caenorhabditis elegans (worm) ENSCAFP00000019138 Canis familiaris (dog) JA02411 Caenorhabditis japonica (nematode) cgd2_1820 Cryptosporidium parvum (protozoan parasite) CPIJ000285 Culex pipens (mosquito) ENSCPOP00000005903 Cavia porcellus (guinea pig) RP25547 Caenorhabditis remanei (nematode) ENSCSAVP00000010586 Ciona savignyi (sedentary tunicate) 148333 Capitella spl (polychaete worm) 65278 Daphnia pulex (daphnia) ENSDARP00000046780 Danio rerio (zebra fish) ENSECAP00000022605 Equus caballus (horse) XP_653702 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000022426 Gymnopilus aculeatus (mushroom) ENSGALP00000011262 Gallus gallus (chicken) 188445 Hypsipyla robusta (cedar shoot borer) ENSP00000320508 Homo sapiens (human) ISCW015263-PA Ixodes scapularis (deer tick) 204992 Lottia gigantea (owl limpet) ENSMODP00000012024 Monodelphis domestica (gray opossum) ENSMUSP00000067053 Mus musculus (house mouse) 245009 Nematostella vectensis (starlet anemone) XP_001600631.1 Nasonia vitripennis (wasp) ENSOANP00000023080 Ornithorynchus anatinus (platypus) ENSORLP00000010485 Oryzias latipes (japanese killifish) PHUM004842-PA Pediculus humanus (human body louse) PP22446 Pristionchus pacificus (nematode) ENSPPYP00000013084 Pongo pygmaeus (orangutan) 551914 Populus trichocarpa (black cottonwood) ENSPTRP00000024567 Pan troglodytes (chimpanzee) ENSRNOP00000026134 Rattus norvegicus (norway rat) YER116C Saccharomyces cerevisiae (budding yeast) Smp_026260 Schistosoma mansoni (trematode parasite) XP_001175718.1 Strongylocentrotus purpuratus (purple sea urchin) 50677 Trichoplax adhaerens (metazoa) XP_970269.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011936 Tetraodon nigroviridis (green spotted pufferfish) ENSXETP00000009063 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12560 NV11028 LH16227 ISCW015263 FBgn0233571 FBgn0227196 FBgn0205758 FBgn0187435 FBgn0177395 FBgn0250037 JGI_V11_65278 FBgn0244032 FBgn0160509 FBgn0160508 FBgn0151717 FBgn0151716 FBgn0150509 FBgn0138489 FBgn0052581 FBgn0119687 FBgn0111575 FBgn0096861 FBgn0096752 CPIJ000285 BGIBMGA002862 ACYPI007387 ACYPI006552 GB10028 AGAP006041 AAEL006550 PHUM291640 GLEAN_12429
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	33461 w* P{EP}CG8974G757
Harvard	- PBac{WH}CG8974f07310
Genomic Clones ( 2 )
	BACR22H11 BACR25C18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 111 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH14055 RE35552
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH10585 GH10704 GH13333 GH14023 GH21354 GH22409 GM10733 GM28646 LD16445 LD21237 LD40273 LD44557 LP02434 RE08016 RE11602 RE12329 RE14882 RE36771 RE39024 RE49796 RE57371 RE57660 RE65635 RH25632 RH27910 RH51481 SD12788 SD21926 SD24338
Other clones	15374 61251 66542 66845 104051 148758 165025 165534 190368 214255.35 214289.33 214311.32 214345.32 214345.33 214569.30 bs21g11 bs74d03 CK01.20D.C4 CK01.50C.D3 CK01.60A.F8 CK01.100B.F12 CK01.105B.F8 CK01.106B.H10 CK01.111A.D10 CK01.130D.E3 Dmel_dig_002853_0680_0680 Dmel_dig_013303_0698_1676 EC37619 EK040514 EK063356 EK088663 EK091540 EK100518 EK131714 EK194362 EK195215 EK255039 EK269835 EK270646 EK292733 EP06925 EP08013 EP08027 EP15023 EP15155 EP19150 ESG0113c.B21.1_H08 FGH121D12 FGM325D05 IP04768 IP15672 RE01614 RP003007863 RP003083917 RP003107758 RP003121850 RP003191892 RP003201838 RP003221162 RP003258437 RP003267444 RP003328207 RP003340917 RP003342005 RP003352046 RP003360239 RP003368139 RP003372425 RP003377647 RP003383725 RP003404571 RP003471544 RP003483783 RP003504080 RP003522078 RP003525285 RP003577540 RP003608291 RP003614268 RP003675246
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030693 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32532
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132848 NM_167462 NM_167463 NM_206725 NM_206726 RefSeq (Proteins) • NP_573076 NP_727896 NP_727897 NP_996448 NP_996449 DDBJ / EMBL / GenBank • AAF48517 AAG22354 AAG22355 AAL25336 AAS65349 AAS65350 AI113991 AI238069 AI513288 AI946180 AY060297 CZ490126 Entrez Gene - A searchable database of RefSeq genes. • 32532 UniProtKB/TrEMBL • Q9VXP1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, RING-type (IPR001841) Zinc finger, RING-type, conserved site (IPR017907) Zinc finger, C3HC4 RING-type (IPR018957) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58880 DroID - A comprehensive database of gene and protein interactions. • FBgn0030693 DRSC - Results from RNAi screens. • FBgn0030693 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030693 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32581-RA;CG8974-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030693 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32532 InParanoid A subset of ortholog calls from InParanoid. • AAEL006550-PA Aedes aegypti (mosquito) AGAP006041-PA Anopheles gambiae (mosquito) XP_392285.1 Apis mellifera (honey bee) XP_001947943.1 Acyrthosiphon pisum (pea aphid) XP_001950503.1 Acyrthosiphon pisum (pea aphid) At2g23780.1 Arabidopsis thaliana (wall cress) 86096 Batrachochytrium dendrobatidis (chytrid fungus) 141138 Branchiostoma floridae (lancelet) 141161 Branchiostoma floridae (lancelet) XP_001902780.1 Brugia malayi (roundworm nematode) BGIBMGA002862-PA Bombyx mori (silk worm) ENSBTAP00000003661 Bos taurus (bovine) CBP19809 Caenorhabditis briggsae (nematode) CE01498 Caenorhabditis elegans (worm) ENSCAFP00000019138 Canis familiaris (dog) JA02411 Caenorhabditis japonica (nematode) cgd2_1820 Cryptosporidium parvum (protozoan parasite) CPIJ000285 Culex pipens (mosquito) ENSCPOP00000005903 Cavia porcellus (guinea pig) RP25547 Caenorhabditis remanei (nematode) ENSCSAVP00000010586 Ciona savignyi (sedentary tunicate) 148333 Capitella spl (polychaete worm) 65278 Daphnia pulex (daphnia) ENSDARP00000046780 Danio rerio (zebra fish) ENSECAP00000022605 Equus caballus (horse) XP_653702 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000022426 Gymnopilus aculeatus (mushroom) ENSGALP00000011262 Gallus gallus (chicken) 188445 Hypsipyla robusta (cedar shoot borer) ENSP00000320508 Homo sapiens (human) ISCW015263-PA Ixodes scapularis (deer tick) 204992 Lottia gigantea (owl limpet) ENSMODP00000012024 Monodelphis domestica (gray opossum) ENSMUSP00000067053 Mus musculus (house mouse) 245009 Nematostella vectensis (starlet anemone) XP_001600631.1 Nasonia vitripennis (wasp) ENSOANP00000023080 Ornithorynchus anatinus (platypus) ENSORLP00000010485 Oryzias latipes (japanese killifish) PHUM004842-PA Pediculus humanus (human body louse) PP22446 Pristionchus pacificus (nematode) ENSPPYP00000013084 Pongo pygmaeus (orangutan) 551914 Populus trichocarpa (black cottonwood) ENSPTRP00000024567 Pan troglodytes (chimpanzee) ENSRNOP00000026134 Rattus norvegicus (norway rat) YER116C Saccharomyces cerevisiae (budding yeast) Smp_026260 Schistosoma mansoni (trematode parasite) XP_001175718.1 Strongylocentrotus purpuratus (purple sea urchin) 50677 Trichoplax adhaerens (metazoa) XP_970269.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011936 Tetraodon nigroviridis (green spotted pufferfish) ENSXETP00000009063 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32532 modMine - Data generated by the modENCODE project. • FBgn0030693 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12560 NV11028 LH16227 ISCW015263 FBgn0233571 FBgn0227196 FBgn0205758 FBgn0187435 FBgn0177395 FBgn0250037 JGI_V11_65278 FBgn0244032 FBgn0160509 FBgn0160508 FBgn0151717 FBgn0151716 FBgn0150509 FBgn0138489 FBgn0052581 FBgn0119687 FBgn0111575 FBgn0096861 FBgn0096752 CPIJ000285 BGIBMGA002862 ACYPI007387 ACYPI006552 GB10028 AGAP006041 AAEL006550 PHUM291640 GLEAN_12429
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG8974 (Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 10 )
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979]
Personal communication to FlyBase	Bellen, 2010.12.8, BDGP_2010_1209.GenExel.xml BDGP_2010_1209.GenExel.xml [FBrf0212439] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]