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Gene Dmel\CG8565

General Information
Symbol	Dmel\CG8565	Species	D. melanogaster
Name		Annotation symbol	CG8565
Feature type	protein_coding_gene	FlyBase ID	FBgn0030697
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	13F9-13F10	Sequence location	X:15,731,863..15,735,093 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG8565 (FBgn0030697). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein kinase activity; protein serine/threonine kinase activity. It is reported to be involved in the biological process: protein phosphorylation. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected. Peak expression observed at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body. Comments on Affy2 ProbeSet: ProbeSet 1634499_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG8565. Gene sequence location is X:15731863..15735093.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN25338 HFA20112 BKN50362 BKN50233
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 13F9-13F10   Limits computationally determined from genome sequence between P{EP}BEST:RE35685EP1581&P{EP}sdEP1088 and P{EP}Gβ13FEP1071
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG8565 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG8565-RA FBtr0074103  NM_132852   2546   790
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG8565-PA   FBpp0073917   90.7   790   9.13     NP_573080   AAF48523
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48523   BT004485   BT100135   EC050987   EC055968   EW712894
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VXN5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030697    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030697 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected. Peak expression observed at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030697 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    49 larva L3 puffstage 1-2    803 larva L3 puffstage 3-6    1519 larva L3 puffstage 7-9    2038 white prepupae new    1867 white prepupae 12hr    3030 white prepupae 24hr    4304 pupae 2d postWPP    5233 pupae 3d postWPP    4516 pupae 4d postWPP    3214 adult male 01day    5667 adult male 05day    7962 adult male 30day    6940 adult female 01day    4 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    49 larva L3 puffstage 1-2  (803) larva L3 puffstage 3-6  (1519) larva L3 puffstage 7-9  (2038) white prepupae new  (1867) white prepupae 12hr  (3030) white prepupae 24hr  (4304) pupae 2d postWPP  (5233) pupae 3d postWPP  (4516) pupae 4d postWPP  (3214) adult male 01day  (5667) adult male 05day  (7962) adult male 30day  (6940) adult female 01day    4 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    49 larva L3 puffstage 1-2    803 larva L3 puffstage 3-6  (1519) larva L3 puffstage 7-9  (2038) white prepupae new  (1867) white prepupae 12hr  (3030) white prepupae 24hr  (4304) pupae 2d postWPP  (5233) pupae 3d postWPP  (4516) pupae 4d postWPP  (3214) adult male 01day  (5667) adult male 05day  (7962) adult male 30day  (6940) adult female 01day    4 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    49 larva L3 puffstage 1-2    803 larva L3 puffstage 3-6    1519 larva L3 puffstage 7-9    2038 white prepupae new    1867 white prepupae 12hr    3030 white prepupae 24hr    4304 pupae 2d postWPP    5233 pupae 3d postWPP    4516 pupae 4d postWPP    3214 adult male 01day    5667 adult male 05day    7962 adult male 30day    6940 adult female 01day    4 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    49 larva L3 puffstage 1-2    803 larva L3 puffstage 3-6    1519 larva L3 puffstage 7-9    2038 white prepupae new    1867 white prepupae 12hr    3030 white prepupae 24hr    4304 pupae 2d postWPP    5233 pupae 3d postWPP    4516 pupae 4d postWPP    3214 adult male 01day    5667 adult male 05day    7962 adult male 30day    6940 adult female 01day    4 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030697 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    49 larva L3 puffstage 1-2    803 larva L3 puffstage 3-6    1519 larva L3 puffstage 7-9    2038 white prepupae new    1867 white prepupae 12hr    3030 white prepupae 24hr    4304 pupae 2d postWPP    5233 pupae 3d postWPP    4516 pupae 4d postWPP    3214 adult male 01day    5667 adult male 05day    7962 adult male 30day    6940 adult female 01day    4 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    49 larva L3 puffstage 1-2  (803) larva L3 puffstage 3-6  (1519) larva L3 puffstage 7-9  (2038) white prepupae new  (1867) white prepupae 12hr  (3030) white prepupae 24hr  (4304) pupae 2d postWPP  (5233) pupae 3d postWPP  (4516) pupae 4d postWPP  (3214) adult male 01day  (5667) adult male 05day  (7962) adult male 30day  (6940) adult female 01day    4 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    49 larva L3 puffstage 1-2    803 larva L3 puffstage 3-6  1519 larva L3 puffstage 7-9  2038 white prepupae new  1867 white prepupae 12hr  (3030) white prepupae 24hr  (4304) pupae 2d postWPP  (5233) pupae 3d postWPP  (4516) pupae 4d postWPP  (3214) adult male 01day  (5667) adult male 05day  (7962) adult male 30day  (6940) adult female 01day    4 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    49 larva L3 puffstage 1-2    803 larva L3 puffstage 3-6    1519 larva L3 puffstage 7-9    2038 white prepupae new    1867 white prepupae 12hr    3030 white prepupae 24hr    4304 pupae 2d postWPP    5233 pupae 3d postWPP    4516 pupae 4d postWPP    3214 adult male 01day    5667 adult male 05day    7962 adult male 30day    6940 adult female 01day    4 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    5 embryo 10-12hr    2 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    49 larva L3 puffstage 1-2    803 larva L3 puffstage 3-6    1519 larva L3 puffstage 7-9    2038 white prepupae new    1867 white prepupae 12hr    3030 white prepupae 24hr    4304 pupae 2d postWPP    5233 pupae 3d postWPP    4516 pupae 4d postWPP    3214 adult male 01day    5667 adult male 05day    7962 adult male 30day    6940 adult female 01day    4 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030697    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030697 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030697 expression level Tissue   Expression Level Larval Central Nervous System    8.575 Larval Midgut no informative data Larval Hindgut    3.1 Larval Malpighian Tubules    4.6 Larval Fat Body    326.4 Larval Salivary Gland    8.3 Larval Trachea    9.575 Larval Carcass no informative data Adult Head    5.7 Adult Eye    3.25 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    6.4 Adult Crop    5 Adult Midgut no informative data Adult Hindgut    5.8 Adult Malpighian Tubules    4.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.95 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis    1590.7 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    8.575 Larval Midgut no informative data Larval Hindgut    3.1 Larval Malpighian Tubules    4.6 Larval Fat Body    326.4 Larval Salivary Gland    8.3 Larval Trachea    9.575 Larval Carcass no informative data Adult Head    5.7 Adult Eye    3.25 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    6.4 Adult Crop    5 Adult Midgut no informative data Adult Hindgut    5.8 Adult Malpighian Tubules    4.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.95 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis  (1590.7) Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    8.575 Larval Midgut no informative data Larval Hindgut    3.1 Larval Malpighian Tubules    4.6 Larval Fat Body    326.4 Larval Salivary Gland    8.3 Larval Trachea    9.575 Larval Carcass no informative data Adult Head    5.7 Adult Eye    3.25 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    6.4 Adult Crop    5 Adult Midgut no informative data Adult Hindgut    5.8 Adult Malpighian Tubules    4.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.95 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis  (1590.7) Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    8.575 Larval Midgut no informative data Larval Hindgut    3.1 Larval Malpighian Tubules    4.6 Larval Fat Body    326.4 Larval Salivary Gland    8.3 Larval Trachea    9.575 Larval Carcass no informative data Adult Head    5.7 Adult Eye    3.25 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    6.4 Adult Crop    5 Adult Midgut no informative data Adult Hindgut    5.8 Adult Malpighian Tubules    4.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.95 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis    1590.7 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030697 expression level Tissue   Expression Level Larval Central Nervous System    8.575 Larval Midgut no informative data Larval Hindgut    3.1 Larval Malpighian Tubules    4.6 Larval Fat Body    326.4 Larval Salivary Gland    8.3 Larval Trachea    9.575 Larval Carcass no informative data Adult Head    5.7 Adult Eye    3.25 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    6.4 Adult Crop    5 Adult Midgut no informative data Adult Hindgut    5.8 Adult Malpighian Tubules    4.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.95 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis    1590.7 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    8.575 Larval Midgut no informative data Larval Hindgut    3.1 Larval Malpighian Tubules    4.6 Larval Fat Body    326.4 Larval Salivary Gland    8.3 Larval Trachea    9.575 Larval Carcass no informative data Adult Head    5.7 Adult Eye    3.25 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    6.4 Adult Crop    5 Adult Midgut no informative data Adult Hindgut    5.8 Adult Malpighian Tubules    4.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.95 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis  (1590.7) Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    8.575 Larval Midgut no informative data Larval Hindgut    3.1 Larval Malpighian Tubules    4.6 Larval Fat Body    326.4 Larval Salivary Gland    8.3 Larval Trachea    9.575 Larval Carcass no informative data Adult Head    5.7 Adult Eye    3.25 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    6.4 Adult Crop    5 Adult Midgut no informative data Adult Hindgut    5.8 Adult Malpighian Tubules    4.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.95 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis  1590.7 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    8.575 Larval Midgut no informative data Larval Hindgut    3.1 Larval Malpighian Tubules    4.6 Larval Fat Body    326.4 Larval Salivary Gland    8.3 Larval Trachea    9.575 Larval Carcass no informative data Adult Head    5.7 Adult Eye    3.25 Adult Brain    5.8 Adult Thoracic-Abdominal Ganglion    6.4 Adult Crop    5 Adult Midgut no informative data Adult Hindgut    5.8 Adult Malpighian Tubules    4.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    0.95 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    5.6 Adult Testis    1590.7 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5.7   NA  Eye    3.25   NA  Brain    5.8   8.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    6.4   NA  Crop    5   no informative data  Midgut    no informative data   3.1  Hindgut    5.8   4.6  Malpighian Tubules    4.4   326.4  Fat Body    no informative data   8.3  Salivary Gland    no informative data   NA  Heart    0.95   9.575  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    5.6   NA  Testis    1590.7   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_33
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030697 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8565-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG8565 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG8565 Class Mutagen Stocks Known lesion CG8565KK104378 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG8565GD13970 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6251 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13970} NA P{KK104378} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein kinase activity inferred from sequence or structural similarity with NCBI:NP_003128 (Mount and Salz, 2000) non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from sequence or structural similarity with UniProtKB:Q9UPE1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG8565 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0030697 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32538
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21919 Dere\GG17897 Dmoj\GI16453 Dper\GL16478 Dpse\GA22600 Dsec\GM22564 Dsim\GD17227 Dvir\GJ15853 Dwil\GK17168 Dyak\GE17205
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • CN02114 Caenorhabditis brenneri (small nematode) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0234683 FBgn0219167 FBgn0203040 FBgn0188790 FBgn0187431 FBgn0177434 FBgn0244003 FBgn0154082 FBgn0139201 FBgn0110117 FBgn0098919
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v100449 P{KK104378}VIE-260B
Genomic Clones ( 2 )
	BACR22H11 BACR25C18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24323
Other clones	GH15551
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	DMG1-chrX.16.100.a EC050987 EC055968
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030697 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32538
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a whole range of mitotic abnormalities, centrosome abnormalities are seen. (Bettencourt-Dias et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132852 RefSeq (Proteins) • NP_573080 DDBJ / EMBL / GenBank • AAF48523 Entrez Gene - A searchable database of RefSeq genes. • 32538 UniProtKB/TrEMBL • Q9VXN5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0030697 DRSC - Results from RNAi screens. • FBgn0030697 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030697 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8565-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030697 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32538 InParanoid A subset of ortholog calls from InParanoid. • CN02114 Caenorhabditis brenneri (small nematode) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32538 modMine - Data generated by the modENCODE project. • FBgn0030697 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0234683 FBgn0219167 FBgn0203040 FBgn0188790 FBgn0187431 FBgn0177434 FBgn0244003 FBgn0154082 FBgn0139201 FBgn0110117 FBgn0098919
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG8565 (Keleman et al., 2009.8.5) SPRK2 (Morrison et al., 2000)
Name Synonym
Secondary FlyBase IDs
References ( 14 )
Research paper	Bettencourt-Dias et al., 2004, Nature 432(7020): 980--987 Genome-wide survey of protein kinases required for cell cycle progression. [FBrf0184171] Allemand et al., 2001, Molec. Cell. Biol. 21(4): 1345--1359 Distinctive features of Drosophila alternative splicing factor RS domain: implication for specific phosphorylation, shuttling, and splicing activation. [FBrf0132409] Mount and Salz, 2000, J. Cell Biol. 150(2): F37--F43 Pre-messenger RNA processing factors in the Drosophila genome. [FBrf0129982]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231] Morrison et al., 2000, J. Cell Biol. 150(2): Table S1. Drosophila protein kinases and phosphatases. [FBrf0132098]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Zhu, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126704]