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Gene Dmel\CG9914

General Information
Symbol	Dmel\CG9914	Species	D. melanogaster
Name		Annotation symbol	CG9914
Feature type	protein_coding_gene	FlyBase ID	FBgn0030737
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	14B9-14B9	Sequence location	X:16,200,945..16,202,426 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG9914 (FBgn0030737). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: 3-hydroxyacyl-CoA dehydrogenase activity; NAD+ binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process; fatty acid metabolic process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: 3-hydroxyacyl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase, C-terminal; 3-hydroxyacyl-CoA dehydrogenase, NAD binding; 3-hydroxyacyl-CoA dehydrogenase, conserved site; 6-phosphogluconate dehydrogenase, C-terminal-like; Dehydrogenase, multihelical; NAD(P)-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, adult salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1627854_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG9914. Gene sequence location is X:16200945..16202426.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 14B9-14B9   Limits computationally determined from genome sequence between P{EP}kat80EP620&P{EP}cazEP1564 and P{EP}Cyp1EP1073&P{EP}Dsp1EP355
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG9914 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG9914-RA FBtr0074240  NM_132886   1171   315
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG9914-PA   FBpp0074019   34.8   315   8.01     NP_573114   AAF48586
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • 3-hydroxyacyl-CoA dehydrogenase, C-terminal (IPR006108) 3-hydroxyacyl-CoA dehydrogenase, NAD binding (IPR006176) 3-hydroxyacyl-CoA dehydrogenase, conserved site (IPR006180) 6-phosphogluconate dehydrogenase, C-terminal-like (IPR008927) NAD(P)-binding domain (IPR016040) 3-hydroxyacyl-CoA dehydrogenase (IPR022694) Dehydrogenase, multihelical (IPR013328)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA952045   AE014298 AAF48586   AI260184   BI227895   BI484372   BI627216   BT009948 AAQ22417   CK660583   CO283546   CO298286   CO320075   CO341687   CO345514   EC212473   EC224129   EC253502   EC256782   EC257076   EC258657   EV574973   EV576287   EV594662
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VXI1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, adult salivary gland, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    232.325 Larval Midgut    860.2 Larval Hindgut    446.4 Larval Malpighian Tubules    5636.7 Larval Fat Body    608.9 Larval Salivary Gland    30.2 Larval Trachea    558.725 Larval Carcass    1605.75 Adult Head    1403.6 Adult Eye    278.475 Adult Brain    78.3 Adult Thoracic-Abdominal Ganglion    106.5 Adult Crop    106.7 Adult Midgut    1610.2 Adult Hindgut    380.8 Adult Malpighian Tubules    6203.2 Adult Fat Body    2545 Adult Salivary Gland    315.2 Adult Heart    1314.775 Adult VirginFemale Spermatheca    2178 Adult InseminatedFemale Spermatheca    1222.4 Adult Ovary    144.9 Adult Testis    8.6 Adult Male Accessory Gland    19.4 Adult Carcass    2396.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    232.325 Larval Midgut  (860.2) Larval Hindgut    446.4 Larval Malpighian Tubules  (5636.7) Larval Fat Body  (608.9) Larval Salivary Gland    30.2 Larval Trachea  (558.725) Larval Carcass  (1605.75) Adult Head  (1403.6) Adult Eye    278.475 Adult Brain    78.3 Adult Thoracic-Abdominal Ganglion    106.5 Adult Crop    106.7 Adult Midgut  (1610.2) Adult Hindgut    380.8 Adult Malpighian Tubules  (6203.2) Adult Fat Body  (2545) Adult Salivary Gland    315.2 Adult Heart  (1314.775) Adult VirginFemale Spermatheca  (2178) Adult InseminatedFemale Spermatheca  (1222.4) Adult Ovary    144.9 Adult Testis    8.6 Adult Male Accessory Gland    19.4 Adult Carcass  (2396.6) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    232.325 Larval Midgut    860.2 Larval Hindgut    446.4 Larval Malpighian Tubules  (5636.7) Larval Fat Body    608.9 Larval Salivary Gland    30.2 Larval Trachea    558.725 Larval Carcass  (1605.75) Adult Head  (1403.6) Adult Eye    278.475 Adult Brain    78.3 Adult Thoracic-Abdominal Ganglion    106.5 Adult Crop    106.7 Adult Midgut  (1610.2) Adult Hindgut    380.8 Adult Malpighian Tubules  (6203.2) Adult Fat Body  (2545) Adult Salivary Gland    315.2 Adult Heart  (1314.775) Adult VirginFemale Spermatheca  (2178) Adult InseminatedFemale Spermatheca  (1222.4) Adult Ovary    144.9 Adult Testis    8.6 Adult Male Accessory Gland    19.4 Adult Carcass  (2396.6) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    232.325 Larval Midgut    860.2 Larval Hindgut    446.4 Larval Malpighian Tubules    5636.7 Larval Fat Body    608.9 Larval Salivary Gland    30.2 Larval Trachea    558.725 Larval Carcass    1605.75 Adult Head    1403.6 Adult Eye    278.475 Adult Brain    78.3 Adult Thoracic-Abdominal Ganglion    106.5 Adult Crop    106.7 Adult Midgut    1610.2 Adult Hindgut    380.8 Adult Malpighian Tubules    6203.2 Adult Fat Body    2545 Adult Salivary Gland    315.2 Adult Heart    1314.775 Adult VirginFemale Spermatheca    2178 Adult InseminatedFemale Spermatheca    1222.4 Adult Ovary    144.9 Adult Testis    8.6 Adult Male Accessory Gland    19.4 Adult Carcass    2396.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    232.325 Larval Midgut    860.2 Larval Hindgut    446.4 Larval Malpighian Tubules    5636.7 Larval Fat Body    608.9 Larval Salivary Gland    30.2 Larval Trachea    558.725 Larval Carcass    1605.75 Adult Head    1403.6 Adult Eye    278.475 Adult Brain    78.3 Adult Thoracic-Abdominal Ganglion    106.5 Adult Crop    106.7 Adult Midgut    1610.2 Adult Hindgut    380.8 Adult Malpighian Tubules    6203.2 Adult Fat Body    2545 Adult Salivary Gland    315.2 Adult Heart    1314.775 Adult VirginFemale Spermatheca    2178 Adult InseminatedFemale Spermatheca    1222.4 Adult Ovary    144.9 Adult Testis    8.6 Adult Male Accessory Gland    19.4 Adult Carcass    2396.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    232.325 Larval Midgut  (860.2) Larval Hindgut    446.4 Larval Malpighian Tubules  (5636.7) Larval Fat Body  608.9 Larval Salivary Gland    30.2 Larval Trachea  558.725 Larval Carcass  (1605.75) Adult Head  (1403.6) Adult Eye    278.475 Adult Brain    78.3 Adult Thoracic-Abdominal Ganglion    106.5 Adult Crop    106.7 Adult Midgut  (1610.2) Adult Hindgut    380.8 Adult Malpighian Tubules  (6203.2) Adult Fat Body  (2545) Adult Salivary Gland    315.2 Adult Heart  (1314.775) Adult VirginFemale Spermatheca  (2178) Adult InseminatedFemale Spermatheca  (1222.4) Adult Ovary    144.9 Adult Testis    8.6 Adult Male Accessory Gland    19.4 Adult Carcass  (2396.6) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    232.325 Larval Midgut    860.2 Larval Hindgut    446.4 Larval Malpighian Tubules  (5636.7) Larval Fat Body    608.9 Larval Salivary Gland    30.2 Larval Trachea    558.725 Larval Carcass  1605.75 Adult Head  1403.6 Adult Eye    278.475 Adult Brain    78.3 Adult Thoracic-Abdominal Ganglion    106.5 Adult Crop    106.7 Adult Midgut  1610.2 Adult Hindgut    380.8 Adult Malpighian Tubules  (6203.2) Adult Fat Body  (2545) Adult Salivary Gland    315.2 Adult Heart  1314.775 Adult VirginFemale Spermatheca  (2178) Adult InseminatedFemale Spermatheca  1222.4 Adult Ovary    144.9 Adult Testis    8.6 Adult Male Accessory Gland    19.4 Adult Carcass  (2396.6) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    232.325 Larval Midgut    860.2 Larval Hindgut    446.4 Larval Malpighian Tubules    5636.7 Larval Fat Body    608.9 Larval Salivary Gland    30.2 Larval Trachea    558.725 Larval Carcass    1605.75 Adult Head    1403.6 Adult Eye    278.475 Adult Brain    78.3 Adult Thoracic-Abdominal Ganglion    106.5 Adult Crop    106.7 Adult Midgut    1610.2 Adult Hindgut    380.8 Adult Malpighian Tubules    6203.2 Adult Fat Body    2545 Adult Salivary Gland    315.2 Adult Heart    1314.775 Adult VirginFemale Spermatheca    2178 Adult InseminatedFemale Spermatheca    1222.4 Adult Ovary    144.9 Adult Testis    8.6 Adult Male Accessory Gland    19.4 Adult Carcass    2396.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1403.6   NA  Eye    278.475   NA  Brain    78.3   232.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    106.5   NA  Crop    106.7   860.2  Midgut    1610.2   446.4  Hindgut    380.8   5636.7  Malpighian Tubules    6203.2   608.9  Fat Body    2545   30.2  Salivary Gland    315.2   NA  Heart    1314.775   558.725  Trachea    NA   NA  VirginFemale Spermatheca    2178   NA  InseminatedFemale Spermatheca    1222.4   NA  Ovary    144.9   NA  Testis    8.6   NA  Male Accessory Gland    19.4   1605.75  Carcass    2396.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    12 central nervous system, pupae P8    7 head, virgin 1-day female    218 head, virgin 4-day female    106 head, virgin 20-day female    180 head, mated 1-day female    146 head, mated 4-day female    39 head, mated 20-day female    142 head, mated 1-day male    201 head, mated 4-day male    172 head, mated 20-day male    207 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    73 digestive system, 1-day adult    560 digestive system, 4-day adult    214 digestive system, 20-day adult    352 fat body, larvae L3 wandering    68 fat body, white prepupae    52 fat body, pupae P8    47 carcass, larvae L3 wandering    227 carcass, 1-day adult    123 carcass, 4-day adult    91 carcass, 20-day adult    145 ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    66 accessory gland, mated 4-day male    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    12 central nervous system, pupae P8    7 head, virgin 1-day female  (218) head, virgin 4-day female  (106) head, virgin 20-day female  (180) head, mated 1-day female  (146) head, mated 4-day female  (39) head, mated 20-day female  (142) head, mated 1-day male  (201) head, mated 4-day male  (172) head, mated 20-day male  (207) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering  (73) digestive system, 1-day adult  (560) digestive system, 4-day adult  (214) digestive system, 20-day adult  (352) fat body, larvae L3 wandering  (68) fat body, white prepupae  (52) fat body, pupae P8  (47) carcass, larvae L3 wandering  (227) carcass, 1-day adult  (123) carcass, 4-day adult  (91) carcass, 20-day adult  (145) ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male  (66) accessory gland, mated 4-day male  (54) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    12 central nervous system, pupae P8    7 head, virgin 1-day female  (218) head, virgin 4-day female  106 head, virgin 20-day female  (180) head, mated 1-day female  (146) head, mated 4-day female    39 head, mated 20-day female  (142) head, mated 1-day male  (201) head, mated 4-day male  (172) head, mated 20-day male  (207) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    73 digestive system, 1-day adult  (560) digestive system, 4-day adult  (214) digestive system, 20-day adult  (352) fat body, larvae L3 wandering    68 fat body, white prepupae    52 fat body, pupae P8    47 carcass, larvae L3 wandering  (227) carcass, 1-day adult  (123) carcass, 4-day adult    91 carcass, 20-day adult  (145) ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    66 accessory gland, mated 4-day male    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    12 central nervous system, pupae P8    7 head, virgin 1-day female    218 head, virgin 4-day female    106 head, virgin 20-day female    180 head, mated 1-day female    146 head, mated 4-day female    39 head, mated 20-day female    142 head, mated 1-day male    201 head, mated 4-day male    172 head, mated 20-day male    207 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    73 digestive system, 1-day adult    560 digestive system, 4-day adult    214 digestive system, 20-day adult    352 fat body, larvae L3 wandering    68 fat body, white prepupae    52 fat body, pupae P8    47 carcass, larvae L3 wandering    227 carcass, 1-day adult    123 carcass, 4-day adult    91 carcass, 20-day adult    145 ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    66 accessory gland, mated 4-day male    54 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    12 central nervous system, pupae P8    7 head, virgin 1-day female    218 head, virgin 4-day female    106 head, virgin 20-day female    180 head, mated 1-day female    146 head, mated 4-day female    39 head, mated 20-day female    142 head, mated 1-day male    201 head, mated 4-day male    172 head, mated 20-day male    207 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    73 digestive system, 1-day adult    560 digestive system, 4-day adult    214 digestive system, 20-day adult    352 fat body, larvae L3 wandering    68 fat body, white prepupae    52 fat body, pupae P8    47 carcass, larvae L3 wandering    227 carcass, 1-day adult    123 carcass, 4-day adult    91 carcass, 20-day adult    145 ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    66 accessory gland, mated 4-day male    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    12 central nervous system, pupae P8    7 head, virgin 1-day female  (218) head, virgin 4-day female  (106) head, virgin 20-day female  (180) head, mated 1-day female  (146) head, mated 4-day female  (39) head, mated 20-day female  (142) head, mated 1-day male  (201) head, mated 4-day male  (172) head, mated 20-day male  (207) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering  (73) digestive system, 1-day adult  (560) digestive system, 4-day adult  (214) digestive system, 20-day adult  (352) fat body, larvae L3 wandering  (68) fat body, white prepupae  (52) fat body, pupae P8  (47) carcass, larvae L3 wandering  (227) carcass, 1-day adult  (123) carcass, 4-day adult  (91) carcass, 20-day adult  (145) ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male  (66) accessory gland, mated 4-day male  (54) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    12 central nervous system, pupae P8    7 head, virgin 1-day female  (218) head, virgin 4-day female  106 head, virgin 20-day female  (180) head, mated 1-day female  (146) head, mated 4-day female    39 head, mated 20-day female  142 head, mated 1-day male  (201) head, mated 4-day male  (172) head, mated 20-day male  (207) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    73 digestive system, 1-day adult  (560) digestive system, 4-day adult  (214) digestive system, 20-day adult  (352) fat body, larvae L3 wandering    68 fat body, white prepupae    52 fat body, pupae P8    47 carcass, larvae L3 wandering  (227) carcass, 1-day adult  123 carcass, 4-day adult    91 carcass, 20-day adult  (145) ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    66 accessory gland, mated 4-day male    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    12 central nervous system, pupae P8    7 head, virgin 1-day female    218 head, virgin 4-day female    106 head, virgin 20-day female    180 head, mated 1-day female    146 head, mated 4-day female    39 head, mated 20-day female    142 head, mated 1-day male    201 head, mated 4-day male    172 head, mated 20-day male    207 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    73 digestive system, 1-day adult    560 digestive system, 4-day adult    214 digestive system, 20-day adult    352 fat body, larvae L3 wandering    68 fat body, white prepupae    52 fat body, pupae P8    47 carcass, larvae L3 wandering    227 carcass, 1-day adult    123 carcass, 4-day adult    91 carcass, 20-day adult    145 ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    66 accessory gland, mated 4-day male    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    6 embryo 04-06hr    7 embryo 06-08hr    6 embryo 08-10hr    6 embryo 10-12hr    9 embryo 12-14hr    13 embryo 14-16hr    45 embryo 16-18hr    106 embryo 18-20hr    512 embryo 20-22hr    823 embryo 22-24hr    807 larva L1    328 larva L2    507 larva L3 12hr old    567 larva L3 puffstage 1-2    223 larva L3 puffstage 3-6    142 larva L3 puffstage 7-9    97 white prepupae new    144 white prepupae 12hr    79 white prepupae 24hr    22 pupae 2d postWPP    25 pupae 3d postWPP    54 pupae 4d postWPP    289 adult male 01day    472 adult male 05day    238 adult male 30day    190 adult female 01day    208 adult female 05day    105 adult female 30day    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    6 embryo 04-06hr    7 embryo 06-08hr    6 embryo 08-10hr    6 embryo 10-12hr    9 embryo 12-14hr    13 embryo 14-16hr  (45) embryo 16-18hr  (106) embryo 18-20hr  (512) embryo 20-22hr  (823) embryo 22-24hr  (807) larva L1  (328) larva L2  (507) larva L3 12hr old  (567) larva L3 puffstage 1-2  (223) larva L3 puffstage 3-6  (142) larva L3 puffstage 7-9  (97) white prepupae new  (144) white prepupae 12hr  (79) white prepupae 24hr    22 pupae 2d postWPP    25 pupae 3d postWPP  (54) pupae 4d postWPP  (289) adult male 01day  (472) adult male 05day  (238) adult male 30day  (190) adult female 01day  (208) adult female 05day  (105) adult female 30day  (94) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    6 embryo 04-06hr    7 embryo 06-08hr    6 embryo 08-10hr    6 embryo 10-12hr    9 embryo 12-14hr    13 embryo 14-16hr    45 embryo 16-18hr  106 embryo 18-20hr  (512) embryo 20-22hr  (823) embryo 22-24hr  (807) larva L1  (328) larva L2  (507) larva L3 12hr old  (567) larva L3 puffstage 1-2  (223) larva L3 puffstage 3-6  (142) larva L3 puffstage 7-9    97 white prepupae new  (144) white prepupae 12hr    79 white prepupae 24hr    22 pupae 2d postWPP    25 pupae 3d postWPP    54 pupae 4d postWPP  (289) adult male 01day  (472) adult male 05day  (238) adult male 30day  (190) adult female 01day  (208) adult female 05day  105 adult female 30day    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    6 embryo 04-06hr    7 embryo 06-08hr    6 embryo 08-10hr    6 embryo 10-12hr    9 embryo 12-14hr    13 embryo 14-16hr    45 embryo 16-18hr    106 embryo 18-20hr    512 embryo 20-22hr    823 embryo 22-24hr    807 larva L1    328 larva L2    507 larva L3 12hr old    567 larva L3 puffstage 1-2    223 larva L3 puffstage 3-6    142 larva L3 puffstage 7-9    97 white prepupae new    144 white prepupae 12hr    79 white prepupae 24hr    22 pupae 2d postWPP    25 pupae 3d postWPP    54 pupae 4d postWPP    289 adult male 01day    472 adult male 05day    238 adult male 30day    190 adult female 01day    208 adult female 05day    105 adult female 30day    94 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    6 embryo 04-06hr    7 embryo 06-08hr    6 embryo 08-10hr    6 embryo 10-12hr    9 embryo 12-14hr    13 embryo 14-16hr    45 embryo 16-18hr    106 embryo 18-20hr    512 embryo 20-22hr    823 embryo 22-24hr    807 larva L1    328 larva L2    507 larva L3 12hr old    567 larva L3 puffstage 1-2    223 larva L3 puffstage 3-6    142 larva L3 puffstage 7-9    97 white prepupae new    144 white prepupae 12hr    79 white prepupae 24hr    22 pupae 2d postWPP    25 pupae 3d postWPP    54 pupae 4d postWPP    289 adult male 01day    472 adult male 05day    238 adult male 30day    190 adult female 01day    208 adult female 05day    105 adult female 30day    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    6 embryo 04-06hr    7 embryo 06-08hr    6 embryo 08-10hr    6 embryo 10-12hr    9 embryo 12-14hr    13 embryo 14-16hr  (45) embryo 16-18hr  (106) embryo 18-20hr  (512) embryo 20-22hr  (823) embryo 22-24hr  (807) larva L1  (328) larva L2  (507) larva L3 12hr old  (567) larva L3 puffstage 1-2  (223) larva L3 puffstage 3-6  (142) larva L3 puffstage 7-9  (97) white prepupae new  (144) white prepupae 12hr  (79) white prepupae 24hr    22 pupae 2d postWPP    25 pupae 3d postWPP  (54) pupae 4d postWPP  (289) adult male 01day  (472) adult male 05day  (238) adult male 30day  (190) adult female 01day  (208) adult female 05day  (105) adult female 30day  (94) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    6 embryo 04-06hr    7 embryo 06-08hr    6 embryo 08-10hr    6 embryo 10-12hr    9 embryo 12-14hr    13 embryo 14-16hr    45 embryo 16-18hr  106 embryo 18-20hr  (512) embryo 20-22hr  (823) embryo 22-24hr  (807) larva L1  (328) larva L2  (507) larva L3 12hr old  (567) larva L3 puffstage 1-2  (223) larva L3 puffstage 3-6  142 larva L3 puffstage 7-9    97 white prepupae new  (144) white prepupae 12hr    79 white prepupae 24hr    22 pupae 2d postWPP    25 pupae 3d postWPP    54 pupae 4d postWPP  (289) adult male 01day  (472) adult male 05day  (238) adult male 30day  (190) adult female 01day  (208) adult female 05day  105 adult female 30day    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    6 embryo 04-06hr    7 embryo 06-08hr    6 embryo 08-10hr    6 embryo 10-12hr    9 embryo 12-14hr    13 embryo 14-16hr    45 embryo 16-18hr    106 embryo 18-20hr    512 embryo 20-22hr    823 embryo 22-24hr    807 larva L1    328 larva L2    507 larva L3 12hr old    567 larva L3 puffstage 1-2    223 larva L3 puffstage 3-6    142 larva L3 puffstage 7-9    97 white prepupae new    144 white prepupae 12hr    79 white prepupae 24hr    22 pupae 2d postWPP    25 pupae 3d postWPP    54 pupae 4d postWPP    289 adult male 01day    472 adult male 05day    238 adult male 30day    190 adult female 01day    208 adult female 05day    105 adult female 30day    94 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    7 embryonic Kc167    1 embryonic S1    1 embryonic S3    3 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    7 embryonic Kc167    1 embryonic S1    1 embryonic S3    3 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21  (29) wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    7 embryonic Kc167    1 embryonic S1    1 embryonic S3    3 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    7 embryonic Kc167    1 embryonic S1    1 embryonic S3    3 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    7 embryonic Kc167    1 embryonic S1    1 embryonic S3    3 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    7 embryonic Kc167    1 embryonic S1    1 embryonic S3    3 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21  29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    7 embryonic Kc167    1 embryonic S1    1 embryonic S3    3 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    7 embryonic Kc167    1 embryonic S1    1 embryonic S3    3 leg disc CME L1    1 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    29 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    29 heat shock, 4-day adult    210 Cadmium 50 mM 6 hrs, larvae L3    457 Cadmium 50 mM 12 hrs, larvae L3    211 Cadmium 50 mM 48 hrs, 4-day adult    259 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    215 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    131 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    544 Ethanol 10% 3 hrs, larvae L3    480 Caffeine 1.5 mg/ml 4 hrs, larvae L3    332 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    64 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    83 Paraquat 10 mM 48 hrs, 4-day adult    150 Rotenone 2 μg 12 hrs, larvae L3    419 Rotenone 8 μg 12 hrs, larvae L3    465 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (38) cold shock, 4-day adult  (29) heat shock, 4-day adult  (210) Cadmium 50 mM 6 hrs, larvae L3  (457) Cadmium 50 mM 12 hrs, larvae L3  (211) Cadmium 50 mM 48 hrs, 4-day adult  (259) Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3  (215) Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3  (131) Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3  (48) Ethanol 5% 3 hrs, larvae L3  (544) Ethanol 10% 3 hrs, larvae L3  (480) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (332) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (64) Caffeine 25 mg/ml 48 hrs, 4-day adult  (32) Paraquat 5 mM 48 hrs, 4-day adult  (83) Paraquat 10 mM 48 hrs, 4-day adult  (150) Rotenone 2 μg 12 hrs, larvae L3  (419) Rotenone 8 μg 12 hrs, larvae L3  (465) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    29 heat shock, 4-day adult  (210) Cadmium 50 mM 6 hrs, larvae L3  (457) Cadmium 50 mM 12 hrs, larvae L3  (211) Cadmium 50 mM 48 hrs, 4-day adult  (259) Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3  (215) Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3  (131) Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3  (544) Ethanol 10% 3 hrs, larvae L3  (480) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (332) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    64 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    83 Paraquat 10 mM 48 hrs, 4-day adult  (150) Rotenone 2 μg 12 hrs, larvae L3  (419) Rotenone 8 μg 12 hrs, larvae L3  (465) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    29 heat shock, 4-day adult    210 Cadmium 50 mM 6 hrs, larvae L3    457 Cadmium 50 mM 12 hrs, larvae L3    211 Cadmium 50 mM 48 hrs, 4-day adult    259 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    215 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    131 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    544 Ethanol 10% 3 hrs, larvae L3    480 Caffeine 1.5 mg/ml 4 hrs, larvae L3    332 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    64 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    83 Paraquat 10 mM 48 hrs, 4-day adult    150 Rotenone 2 μg 12 hrs, larvae L3    419 Rotenone 8 μg 12 hrs, larvae L3    465 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    29 heat shock, 4-day adult    210 Cadmium 50 mM 6 hrs, larvae L3    457 Cadmium 50 mM 12 hrs, larvae L3    211 Cadmium 50 mM 48 hrs, 4-day adult    259 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    215 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    131 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    544 Ethanol 10% 3 hrs, larvae L3    480 Caffeine 1.5 mg/ml 4 hrs, larvae L3    332 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    64 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    83 Paraquat 10 mM 48 hrs, 4-day adult    150 Rotenone 2 μg 12 hrs, larvae L3    419 Rotenone 8 μg 12 hrs, larvae L3    465 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (38) cold shock, 4-day adult  29 heat shock, 4-day adult  (210) Cadmium 50 mM 6 hrs, larvae L3  (457) Cadmium 50 mM 12 hrs, larvae L3  (211) Cadmium 50 mM 48 hrs, 4-day adult  (259) Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3  (215) Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3  (131) Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3  (48) Ethanol 5% 3 hrs, larvae L3  (544) Ethanol 10% 3 hrs, larvae L3  (480) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (332) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (64) Caffeine 25 mg/ml 48 hrs, 4-day adult  32 Paraquat 5 mM 48 hrs, 4-day adult  (83) Paraquat 10 mM 48 hrs, 4-day adult  (150) Rotenone 2 μg 12 hrs, larvae L3  (419) Rotenone 8 μg 12 hrs, larvae L3  (465) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    29 heat shock, 4-day adult  (210) Cadmium 50 mM 6 hrs, larvae L3  (457) Cadmium 50 mM 12 hrs, larvae L3  (211) Cadmium 50 mM 48 hrs, 4-day adult  (259) Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3  (215) Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3  131 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3  (544) Ethanol 10% 3 hrs, larvae L3  (480) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (332) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    64 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    83 Paraquat 10 mM 48 hrs, 4-day adult  (150) Rotenone 2 μg 12 hrs, larvae L3  (419) Rotenone 8 μg 12 hrs, larvae L3  (465) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    38 cold shock, 4-day adult    29 heat shock, 4-day adult    210 Cadmium 50 mM 6 hrs, larvae L3    457 Cadmium 50 mM 12 hrs, larvae L3    211 Cadmium 50 mM 48 hrs, 4-day adult    259 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    215 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    131 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    544 Ethanol 10% 3 hrs, larvae L3    480 Caffeine 1.5 mg/ml 4 hrs, larvae L3    332 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    64 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    83 Paraquat 10 mM 48 hrs, 4-day adult    150 Rotenone 2 μg 12 hrs, larvae L3    419 Rotenone 8 μg 12 hrs, larvae L3    465 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • RH68464 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030737 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9914-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG9914GD14720 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG9914 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG9914 Class Mutagen Stocks Known lesion CG9914GD14720 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG9914KK108568 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14720} NA P{KK108568} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
3-hydroxyacyl-CoA dehydrogenase activity inferred from electronic annotation with InterPro:IPR006108, InterPro:IPR006176, InterPro:IPR006180, InterPro:IPR022694 (FlyBase Curators et al., 2004-) NAD+ binding inferred from electronic annotation with InterPro:IPR022694 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
fatty acid metabolic process inferred from electronic annotation with InterPro:IPR006108, InterPro:IPR006176, InterPro:IPR006180, InterPro:IPR022694 (FlyBase Curators et al., 2004-) oxidation-reduction process inferred from electronic annotation with InterPro:IPR006108, InterPro:IPR006176, InterPro:IPR006180, InterPro:IPR008927, InterPro:IPR013328, InterPro:IPR022694 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG9914 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58932 DroID - A comprehensive database of gene and protein interactions. • FBgn0030737 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32592
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6BRX5T Dipteran inclusive ortholog search EOG66T39B Insect inclusive ortholog search EOG6KSNFN Arthropod inclusive ortholog search EOG6S1RQ1 Metazoa inclusive ortholog search EOG61CKQF
Orthologs in Drosophila Species (EOG6BRX5T)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG9914     Drosophila sechellia   Dsec\GM13412 Y   Drosophila erecta   Dere\GG19334 Y   Drosophila yakuba   Dyak\GE11007 Y   Drosophila ananassae   Dana\GF19071 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA23040 Y   Drosophila persimilis   Dper\GL21343 Y   Drosophila willistoni   Dwil\GK25055 Y   Drosophila virilis   Dvir\GJ18534 Y   Drosophila mojavensis   Dmoj\GI10976 Y   Drosophila grimshawi   Dgri\GH12278 Y
Orthologs in non-Drosophila Dipterans (EOG66T39B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008006   Anopheles gambiae Malaria mosquito  Agam\AGAP013544   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019115
Orthologs in non-Dipteran Insects (EOG6KSNFN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Cryl1 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007034 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12049 Y Atta cephalotes Leafcutter ant  Acep\ACEP10131 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12821 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22465 Y Linepithema humile Argentine ant  Lhum\LH14207 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24540 Y Solenopsis invicta Red fire ant  Sinv\SINV18591 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001738 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000419 Y Pediculus humanus Human body louse  Phum\PHUM424710 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15170 Y
Orthologs in non-Insect Arthropods (EOG6S1RQ1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_306692 Y Ixodes scapularis Deer tick  Isca\ISCW024631 Y
Orthologs in non-Arthropod Metazoa (EOG61CKQF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y71F9B.9 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024431gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027814gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024430gn Y Danio rerio Zebrafish  Drer\cryl1 Y Xenopus tropicalis Western clawed frog  Xtro\cryl1 Y Gallus gallus Domestic chicken  Ggal\CRYL1 Y Mus musculus House mouse  Mmus\Cryl1 Y Rattus norvegicus Norway rat  Rnor\Cryl1 Y Homo sapiens Human  Hsap\CRYL1 Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\CRYL1
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM13412 Drosophila erecta Dere\GG19334 Drosophila yakuba Dyak\GE11007 Drosophila ananassae Dana\GF19071 Drosophila pseudoobscura pseudoobscura Dpse\GA23040 Drosophila persimilis Dper\GL21343 Drosophila willistoni Dwil\GK25055 Drosophila virilis Dvir\GJ18534 Drosophila mojavensis Dmoj\GI10976 Drosophila grimshawi Dgri\GH12278
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v106649 P{KK108568}VIE-260B v29322 w1118; P{GD14720}v29322 v29323 w1118; P{GD14720}v29323
Genomic Clones ( 2 )
	BACR06P10 BACR13G13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 20 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH68464
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD29074 LP03887 LP19274 RE25279 RE67461
Other clones	72099 72131 214243.47 214319.37 214407.36 214507.39 Dmel_dig_008578_0661_3315 Dmel_dig_010997_0612_1490 Dmel_neb_015546_0624_2815 EK163631 EK172702 EK282101 EP12948 EP22210
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030737 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32592
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132886 RefSeq (Proteins) • NP_573114 DDBJ / EMBL / GenBank • AAF48586 AAQ22417 BI627216 BT009948 Entrez Gene - A searchable database of RefSeq genes. • 32592 UniProtKB/TrEMBL • Q9VXI1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • 3-hydroxyacyl-CoA dehydrogenase, C-terminal (IPR006108) 3-hydroxyacyl-CoA dehydrogenase, NAD binding (IPR006176) 3-hydroxyacyl-CoA dehydrogenase, conserved site (IPR006180) 6-phosphogluconate dehydrogenase, C-terminal-like (IPR008927) NAD(P)-binding domain (IPR016040) 3-hydroxyacyl-CoA dehydrogenase (IPR022694) Dehydrogenase, multihelical (IPR013328) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH68464
Linkouts
	BioGRID - A database of protein and genetic interactions • 58932 DroID - A comprehensive database of gene and protein interactions. • FBgn0030737 DRSC - Results from RNAi screens. • FBgn0030737 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030737 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9914-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030737 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32592 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32592 modMine - Data generated by the modENCODE project. • FBgn0030737
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG9914 (Wang et al., 2004, Legube et al., 2006, Butchar et al., 2012, Terhzaz et al., 2006, Thornton et al., 2010, Gruber and Long, 2009, Lebo et al., 2009, Keleman et al., 2009.8.5, Fujikawa et al., 2009, Carpenter et al., 2009, Cammarato et al., 2011)
Name Synonym	Enoyl-CoA hydratase mitochondrial (de Morais Guedes et al., 2003)
Secondary FlyBase IDs
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 4 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Butchar et al., 2012, Genetics 191(4): 1213--1226 New negative feedback regulators of egfr signaling in Drosophila. [FBrf0219175] Show all research papers ...