FlyBase Gene Report: Dmel\Traf-like

General Information

Symbol

Dmel\Traf-like

Species

D. melanogaster

Name

TNF-receptor-associated factor-like

Annotation Symbol

CG4394

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030748

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Traf3, dTRAF3

Key Links

Genomic Location

Cytogenetic map

14C4-14C4

Sequence location

X:16,415,046..16,417,585 [+]

Recombination map

1-53

RefSeq locus

NC_004354 REGION:16415046..16417585

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:Q9U6M0

(assigned by UniProt )

(Kopp et al., 1999)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables tumor necrosis factor receptor binding

inferred from biological aspect of ancestor with PANTHER:PTN000805720

(assigned by GO_Central )

(Gaudet et al., 2011)

enables ubiquitin protein ligase binding

inferred from biological aspect of ancestor with PANTHER:PTN000805720

(assigned by GO_Central )

(Gaudet et al., 2011)

enables ubiquitin-protein transferase activity

inferred from biological aspect of ancestor with PANTHER:PTN000805648

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in positive regulation of lipophagy

inferred from mutant phenotype

(Lee et al., 2018)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in positive regulation of JNK cascade

inferred from biological aspect of ancestor with PANTHER:PTN000805648

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in protein K63-linked ubiquitination

inferred from biological aspect of ancestor with PANTHER:PTN000805648

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of I-kappaB kinase/NF-kappaB signaling

inferred from biological aspect of ancestor with PANTHER:PTN000805648

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in tumor necrosis factor-mediated signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000805648

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in cytoplasmic side of plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000805720

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in cytoplasm

inferred from sequence or structural similarity with FLYBASE:Traf4; FB:FBgn0026319

(FlyBase Curators, 2008--)

Gene Group (FlyBase)

TNF RECEPTOR ASSOCIATED FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

TNF RECEPTOR ASSOCIATED FACTORS -: TNF receptor associated factors (TRAFs) were originally identified as intracellular signal transducers for members of the TNF receptor (TNFR) family in mammals. In Drosophila, TRAFs act downstream of Toll and other homologous receptors (a function shared with some mammalian TRAFs). TRAFs act as adaptor molecules, binding the cytoplasmic tail of activated receptors to recruit other signalling molecules or complexes. All TRAFs contain a C-terminal TRAF domain which interacts with the receptor. (Adapted from FBrf0135895).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Traf-like for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.39

Gene model reviewed during 5.46

Multiphase exon postulated: reading frame of first coding exon differs in alternative transcripts.

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Traf-like-RA

FBtr0074275

NM_167517

2285

474

Traf-like-RB

FBtr0074274

NM_167518

1829

395

Traf-like-RC

FBtr0074273

NM_132898

2356

452

Traf-like-RD

FBtr0308606

NM_001258784

1877

395

Traf-like-RE

FBtr0308607

NM_001258785

2275

395

Traf-like-RF

FBtr0334036

NM_001272683

2227

395

Traf-like-RG

FBtr0334037

NM_001272684

1878

395

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Traf-like-PA

FBpp0074051

55.9

474

6.30

NP_727976

AAN09408

Traf-like-PB

FBpp0074050

46.7

395

6.26

NP_727977

AAF48607

Traf-like-PC

FBpp0074049

53.6

452

6.51

NP_573126

AAF48608

Traf-like-PD

FBpp0300830

46.7

395

6.26

NP_001245713

AFH07426

Traf-like-PE

FBpp0300831

46.7

395

6.26

NP_001245714

AFH07427

Traf-like-PF

FBpp0306152

46.7

395

6.26

NP_001259612

AGB95454

Traf-like-PG

FBpp0306153

46.7

395

6.26

NP_001259613

AGB95455

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

395 aa isoforms: Traf-like-PB, Traf-like-PD, Traf-like-PE, Traf-like-PF, Traf-like-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Traf-like using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Traf-like_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

garland cell primordium

(Fisher et al., 2012)

Malpighian tubule primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic midgut chamber

(Fisher et al., 2012)

embryonic/larval garland cell

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Traf-like in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Traf-like

View exonic expression by tissue for Dmel\Traf-like

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030748

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0030748

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4394-RC

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4394

Flygut - An atlas of the Drosophila adult midgut

FBgn0030748

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Traf-like

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Traf-like

Transgenic constructs containing regulatory region of Traf-like

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Traf-like^GD11301

viable, with Scer\GAL4^Mef2.PR

Traf-like^GD11301

viable, with Scer\GAL4^pnr-MD237

Traf-like^GD11301

Other Phenotypes

Allele

exocytosis defective | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

Traf-like^HMJ02121

immune response defective | adult stage

Traf-like^Δ

immune response defective | adult stage, with Scer\GAL4^NP0001

Traf-like^{dsRNA.UAS.cLa}

increased mortality | adult stage | conditional

Traf-like^Δ

increased mortality | adult stage | conditional, with Scer\GAL4^NP0001

Traf-like^{dsRNA.UAS.cLa}

size defective | adult stage | RU486 conditional, with Scer\GAL4^GSG5966

Traf-like^UAS.Tag:V5

Phenotype manifest in

Allele

adult midgut, with Scer\GAL4^GSG5966

Traf-like^UAS.Tag:V5

adult midgut | conditional, with Scer\GAL4^NP0001

Traf-like^{dsRNA.UAS.cLa}

autophagosome | adult stage | conditional, with Scer\GAL4^NP0001

Traf-like^{dsRNA.UAS.cLa}

autophagosome | adult stage | RU486 conditional, with Scer\GAL4^GSG5966

Traf-like^UAS.Tag:V5

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

Traf-like^HMJ02121

extracellular matrix | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

Traf-like^HMJ02121

lipid droplet | adult stage | conditional, with Scer\GAL4^NP0001

Traf-like^{dsRNA.UAS.cLa}

lipid droplet | adult stage | RU486 conditional, with Scer\GAL4^GSG5966

Traf-like^UAS.Tag:V5

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\TRAF2

3 of 15

Yes

Hsap\TRAF1

2 of 15

Hsap\TRAF3

2 of 15

Hsap\TRAF5

2 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (12)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Traf2

3 of 15

Yes

Mmus\Traf1

2 of 15

Mmus\Traf3

2 of 15

Mmus\Traf5

2 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Rattus norvegicus (Norway rat) (10)

Rnor\Traf2

3 of 13

Yes

Rnor\Traf1

2 of 13

Yes

Rnor\Traf3

2 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Traf7

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (9)

Xtro\traf2

2 of 12

Yes

Xtro\traf6

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (16)

Drer\LOC100005446

3 of 15

Yes

Drer\traf2a

3 of 15

Yes

Drer\traf2b

3 of 15

Yes

Drer\traf1

2 of 15

Drer\traf5

2 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\trf-2

4 of 15

Yes

Cele\trf-1

2 of 15

Cele\F57B10.4

1 of 15

Yes

Cele\Y22D7AR.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\AT3G11950

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\HAP1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091908O4 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18154

Drosophila persimilis

Dper\GL15839

Drosophila willistoni

Dwil\GK25213

Drosophila virilis

Dvir\GJ18797

Drosophila mojavensis

Dmoj\GI14463

Drosophila grimshawi

Dgri\GH12698

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915048A )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021223

Musca domestica

House fly

Mdoa\17006216

Glossina morsitans

Tsetse fly

Gmor\GMOY001459

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06434

Mayetiola destructor

Hessian fly

Mdes\Mdes005289

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL015342

Aedes aegypti

Yellow fever mosquito

Aaeg\TRAF6

Anopheles darlingi

American malaria mosquito

Adar\ADAC000023

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ010862

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08Z9 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA009461

Danaus plexippus

Monarch butterfly

Dple\DPOGS213331-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL010563

Bombus terrestris

Buff-tailed bumblebee

Bter\15212194

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_01476

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05067

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_01182

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05065

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_07710

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11985

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08VA )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR011324

Strigamia maritima

European centipede

Smar\SMAR006780

Strigamia maritima

European centipede

Smar\SMAR012616

Strigamia maritima

European centipede

Smar\SMAR006779

Strigamia maritima

European centipede

Smar\SMAR003863

Strigamia maritima

European centipede

Smar\SMAR008602

Strigamia maritima

European centipede

Smar\SMAR003136

Strigamia maritima

European centipede

Smar\SMAR000203

Strigamia maritima

European centipede

Smar\SMAR003860

Strigamia maritima

European centipede

Smar\SMAR004726

Strigamia maritima

European centipede

Smar\SMAR003859

Strigamia maritima

European centipede

Smar\SMAR011326

Strigamia maritima

European centipede

Smar\SMAR009499

Strigamia maritima

European centipede

Smar\SMAR007267

Strigamia maritima

European centipede

Smar\SMAR001054

Strigamia maritima

European centipede

Smar\SMAR003595

Strigamia maritima

European centipede

Smar\SMAR011738

Strigamia maritima

European centipede

Smar\SMAR009469

Strigamia maritima

European centipede

Smar\SMAR003861

Strigamia maritima

European centipede

Smar\SMAR011325

Strigamia maritima

European centipede

Smar\SMAR000202

Strigamia maritima

European centipede

Smar\SMAR001052

Strigamia maritima

European centipede

Smar\SMAR006782

Strigamia maritima

European centipede

Smar\SMAR006777

Strigamia maritima

European centipede

Smar\SMAR011740

Strigamia maritima

European centipede

Smar\SMAR006847

Strigamia maritima

European centipede

Smar\SMAR003862

Strigamia maritima

European centipede

Smar\SMAR000500

Strigamia maritima

European centipede

Smar\SMAR011735

Strigamia maritima

European centipede

Smar\SMAR005539

Strigamia maritima

European centipede

Smar\SMAR003868

Strigamia maritima

European centipede

Smar\SMAR001816

Strigamia maritima

European centipede

Smar\SMAR006950

Strigamia maritima

European centipede

Smar\SMAR000201

Strigamia maritima

European centipede

Smar\SMAR001283

Strigamia maritima

European centipede

Smar\SMAR003864

Strigamia maritima

European centipede

Smar\SMAR002799

Strigamia maritima

European centipede

Smar\SMAR009498

Strigamia maritima

European centipede

Smar\SMAR010101

Strigamia maritima

European centipede

Smar\SMAR015070

Strigamia maritima

European centipede

Smar\SMAR013854

Strigamia maritima

European centipede

Smar\SMAR006783

Strigamia maritima

European centipede

Smar\SMAR011737

Strigamia maritima

European centipede

Smar\SMAR007993

Strigamia maritima

European centipede

Smar\SMAR009470

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0DUT )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ciona intestinalis

Vase tunicate

Cint\LOC100184576

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (4)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TRAF2; TNF receptor associated factor 2

3 of 15

601895

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Traf-like - CG10375

two hybrid

(Hu et al., 2017.6.13)

Traf-like - CG13124

two hybrid

(Hu et al., 2017.6.13)

Traf-like - CG14655

two hybrid

(Hu et al., 2017.6.13)

Traf-like - CG15446

two hybrid

(Hu et al., 2017.6.13)

Traf-like - CG30324

two hybrid

(Hu et al., 2017.6.13)

Traf-like - CG31244

two hybrid

(Hu et al., 2017.6.13)

Traf-like - CG32655

two hybrid

(Hu et al., 2017.6.13)

Traf-like - CG43897

two hybrid

(Hu et al., 2017.6.13)

Traf-like - CG4496

two hybrid

(Hu et al., 2017.6.13)

Traf-like - CG9098

two hybrid

(Hu et al., 2017.6.13)

Traf-like - CG9641

two hybrid

(Hu et al., 2017.6.13)

Traf-like - CG9667

two hybrid

(Hu et al., 2017.6.13)

Traf-like - Gs2

two hybrid

(Hu et al., 2017.6.13)

Traf-like - H2.0

two hybrid

(Hu et al., 2017.6.13)

Traf-like - Lmpt

two hybrid

(Hu et al., 2017.6.13)

Traf-like - Regnase-1

two hybrid

(Hu et al., 2017.6.13)

Traf-like - RnpS1

two hybrid

(Hu et al., 2017.6.13)

Traf-like - Tektin-A

two hybrid

(Hu et al., 2017.6.13)

Traf-like - Uxt

two hybrid

(Hu et al., 2017.6.13)

Traf-like - cg

two hybrid

(Hu et al., 2017.6.13)

Traf-like - cmb

two hybrid

(Hu et al., 2017.6.13)

(Lee et al., 2018)

(Hu et al., 2017.6.13)

Traf-like - sigmar

two hybrid

(Hu et al., 2017.6.13)

Traf-like - sm

two hybrid

(Hu et al., 2017.6.13)

Traf-like - spas

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Lee et al., 2018)

suppressible

(Lee et al., 2018)

suppressible

(Lee et al., 2018)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cad99C

suppressible

Traf-like

(Lee et al., 2018)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58951

DroID - A comprehensive database of gene and protein interactions.

FBgn0030748

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32611

MIST (protein-protein) - An integrated Molecular Interaction Database

Traf-like

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-53

Cytogenetic map

14C4-14C4

Sequence location

X:16,415,046..16,417,585 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

14C4-14C4

Limits computationally determined from genome sequence between P{EP}EP1493^EP1493 and P{EP}EP1547^EP1547

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-53

(FlyBase, 2016)

1-54.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Bloomington

42549

y¹ v¹; P{TRiP.HMJ02121}attP40

VDRC

v34835

w¹¹¹⁸; P{GD11301}v34835

v34836

w¹¹¹⁸; P{GD11301}v34836

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (114)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030748

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030748

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32611

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Traf3 CG4394

(Grech et al., 2000)

Source for identity of: Traf-like Traf3

(Leptin et al., 2008.2.11)

Source for database merge of

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32611

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030748

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030748

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Traf-like_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4394

Flygut - An atlas of the Drosophila adult midgut

FBgn0030748

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32611

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007710

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4394

modMine - A data warehouse for the modENCODE project

FBgn0030748

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q8IR14

Linkouts

BioGRID - A database of protein and genetic interactions.

58951

DroID - A comprehensive database of gene and protein interactions.

FBgn0030748

DRSC - Results frm RNAi screens

FBgn0030748

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0030748

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4394-RC

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030748

FlyMine - An integrated database for Drosophila genomics

FBgn0030748

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32611

MIST (protein-protein) - An integrated Molecular Interaction Database

Traf-like

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG4394

(Hosono et al., 2015, Ni et al., 2010.12.1)

TRAF3

(Lee et al., 2018, Sun et al., 2002)

Traf-like

(Hu et al., 2017.6.13, Kavi et al., 2015, Chintapalli et al., 2013, Leptin et al., 2008.2.11)

Traf-related

(Leptin et al., 2008.2.11)

Traf3

(Ayroles et al., 2009, Doumanis et al., 2009, Hill-Burns and Clark, 2009, Leptin et al., 2008.2.11, Rehwinkel et al., 2004, Stanyon et al., 2004)

dTRAF3

(Leclerc and Reichhart, 2004, Wu and Arron, 2003, Grech et al., 2000)

Name Synonyms

TNF-receptor-associated factor-like

Traf3

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (39)

The following external sites may use different assemblies or annotations than FlyBase.

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