FB2025_01 , released February 20, 2025
Gene: Dmel\AnxB11
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General Information
Symbol
Dmel\AnxB11
Species
D. melanogaster
Name
Annexin B11
Annotation Symbol
CG9968
Feature Type
FlyBase ID
FBgn0030749
Gene Model Status
Stock Availability
Gene Summary
Contribute a Gene Snapshot for this gene.
Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
1-53
RefSeq locus
NC_004354 REGION:16416958..16422265
Sequence
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity with UniProtKB:P50995
Cellular Component (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000052507
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000052508
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000052507
is_active_in vesicle membrane
inferred from biological aspect of ancestor with PANTHER:PTN000052508
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the annexin family. (Q9VXG4)
Summaries
Gene Group (FlyBase)
ANNEXINS -
Annexins are Ca2+-dependent, phospholipid-binding proteins that are proposed to have multiple roles in membrane traffic. They contain a seventy amino acid sequence repeated four to eight times that mediates their Ca2+- and phospholipid-binding properties. (Adapted from PMID:11917092).
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\AnxB11 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VXG4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0074302
1233
322
FBtr0074303
1731
511
FBtr0334038
1429
322
FBtr0334039
1905
295
FBtr0334040
2485
511
FBtr0334041
1375
322
FBtr0334042
2927
511
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FBpp0074077
36.3
322
6.41
FBpp0074078
56.2
511
7.15
FBpp0306154
36.3
322
6.41
FBpp0306155
33.4
295
6.27
FBpp0306157
36.3
322
6.41
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

322 aa isoforms: AnxB11-PA, AnxB11-PC, AnxB11-PF
511 aa isoforms: AnxB11-PB, AnxB11-PE, AnxB11-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.

(UniProt, Q9VXG4)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AnxB11 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.13

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\AnxB11 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of AnxB11
Transgenic constructs containing regulatory region of AnxB11
Aberrations (Deficiencies and Duplications) ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (15)
13 of 14
Yes
Yes
12 of 14
No
Yes
 
3  
9 of 14
No
Yes
9 of 14
No
Yes
8 of 14
No
Yes
7 of 14
No
No
7 of 14
No
Yes
7 of 14
No
No
7 of 14
No
No
6 of 14
No
Yes
6 of 14
No
Yes
6 of 14
No
Yes
5 of 14
No
Yes
4 of 14
No
No
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (12)
14 of 14
Yes
Yes
12 of 14
No
Yes
9 of 14
No
Yes
9 of 14
No
Yes
7 of 14
No
No
7 of 14
No
No
7 of 14
No
Yes
7 of 14
No
No
6 of 14
No
No
6 of 14
No
Yes
5 of 14
No
No
5 of 14
No
Yes
Mus musculus (laboratory mouse) (12)
14 of 14
Yes
Yes
12 of 14
No
Yes
8 of 14
No
Yes
8 of 14
No
Yes
8 of 14
No
Yes
8 of 14
No
Yes
8 of 14
No
Yes
7 of 14
No
Yes
7 of 14
No
Yes
7 of 14
No
Yes
6 of 14
No
Yes
5 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (20)
11 of 13
Yes
Yes
9 of 13
No
Yes
6 of 13
No
Yes
5 of 13
No
No
5 of 13
No
Yes
5 of 13
No
Yes
5 of 13
No
No
4 of 13
No
Yes
4 of 13
No
No
4 of 13
No
No
3 of 13
No
No
2 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Danio rerio (Zebrafish) (19)
12 of 14
Yes
Yes
12 of 14
Yes
Yes
9 of 14
No
Yes
9 of 14
No
Yes
9 of 14
No
Yes
9 of 14
No
Yes
9 of 14
No
Yes
9 of 14
No
Yes
8 of 14
No
Yes
8 of 14
No
Yes
7 of 14
No
No
6 of 14
No
No
6 of 14
No
No
6 of 14
No
No
6 of 14
No
Yes
5 of 14
No
Yes
4 of 14
No
Yes
1 of 14
No
Yes
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
12 of 14
Yes
Yes
9 of 14
No
Yes
7 of 14
No
Yes
5 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (9)
6 of 12
Yes
No
6 of 12
Yes
No
6 of 12
Yes
No
Arabidopsis thaliana (thale-cress) (8)
12 of 13
Yes
Yes
10 of 13
No
Yes
9 of 13
No
No
9 of 13
No
No
9 of 13
No
No
9 of 13
No
No
7 of 13
No
No
3 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:AnxB11. Refer to their site for version information.
Paralogs
Paralogs (via DIOPT v9.1)
Drosophila melanogaster (Fruit fly) (2)
11 of 13
10 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 1 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Dmel gene
    Ortholog showing functional complementation
    Supporting References
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Other Interaction Browsers
    Summary of Genetic Interactions
    esyN Network Diagram
    Other Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-53
    Cytogenetic map
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    14C4-14C4
    Limits computationally determined from genome sequence between P{EP}EP1493EP1493 and P{EP}EP1547EP1547
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (16)
    Genomic Clones (15)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (46)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected.

        Relationship to Other Genes
        Source for database merge of

        Source for merge of: Anxb11 BcDNA:GH16395

        Additional comments

        Source for identity of Anxb11 CG9968 was sequence comparison ( date:000407 ).

        Source for merge of Anxb11 BcDNA:GH16395 was TrEMBL update ( date:020807 ).

        Nomenclature History
        Source for database identify of

        Source for identity of: Anxb11 CG9968

        Source for identity of: AnxB11 Anxb11

        Nomenclature comments

        Renamed from 'Anxb11' to 'AnxB11' in order to make the nomenclature of D. melanogaster Annexins consistent with each other and with the standard Annexin nomenclature.

        Etymology
        Synonyms and Secondary IDs (11)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 56 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        MIST (protein-protein) - An integrated Molecular Interaction Database
        References (69)