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Gene Dmel\Anxb11

General Information
Symbol	Dmel\Anxb11	Species	D. melanogaster
Name	Annexin B11	Annotation symbol	CG9968
Feature type	protein_coding_gene	FlyBase ID	FBgn0030749
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	14C4-14C4	Sequence location	X:16,311,269..16,316,249 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Annexin B11 is referred to in FlyBase by the symbol Dmel\Anxb11 (CG9968, FBgn0030749). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence that it is involved in the biological process: regulation of cell shape; cell adhesion. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Annexin; Annexin repeat; Annexin repeat, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult female reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625145_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Anxb11. Gene sequence location is X:16311269..16316249.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 22 of adulthood day 20 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features BKN27526 HFA19331
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 14C4-14C4   Limits computationally determined from genome sequence between P{EP}EP1493EP1493 and P{EP}EP1547EP1547
Experimentally Determined Cytological Location
Cytogenetic map Notes References 14C6-14C6     (Fernandez, 2000.3.29)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Anxb11 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Anxb11-RA FBtr0074302  NM_078646   1670   322 Anxb11-RB FBtr0074303  NM_167519   2194   511
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Anxb11-PA   FBpp0074077   36.3   322   6.41     NP_523370   AAF48610 Anxb11-PB   FBpp0074078   56.2   511   7.15     NP_727978   AAF48609
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Annexin (IPR001464) Annexin repeat, conserved site (IPR018252) Annexin repeat (IPR018502)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA536304   AA803645   AE014298 AAF48609   AE014298 AAF48610   AI107820   AI293253   AI406093   AJ276963 CAB86189   AW940623   AY058397 AAL13626   AY122138 AAM52650   BE978546   BI163953   BI166075   BI173181   BI173274   BI173960   BI214679   BI232731   BI234187   BI234636   BI234910   BI238415   BI242017   BI243355   BI356355   BI366973   BI368529   BI372487   BI373067   BI373180   BI484146   BI485188   BI486995   BI606036   BI630313   BP549867   BP549868   BP551663   BP551664   BP557034   BP557035   BQ102763   BT125828   CA803935   CA804213   CA806283   CA806886   CO178257   CO178613   CO268329   CO271974   CO272119   CO282330   CO284133   CO298706   CO299944   CO301550   CO302718   CO303154   CO305614   CO311511   CO326796   CO328278   CO332084   CO342221   CO343471   EC062981   EC067767   EC071649   EC077026   EC084968   EC088502   EC202444   EC209194   EC230206   EC231577   EC248229   EC257359   GH807767
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VXG3 Q9VXG4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030749    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030749 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030749 expression level Developmental Stage   Expression Level embryo 00-02hr    1703 embryo 02-04hr    2012 embryo 04-06hr    2581 embryo 06-08hr    4942 embryo 08-10hr    6202 embryo 10-12hr    7124 embryo 12-14hr    5634 embryo 14-16hr    6045 embryo 16-18hr    6179 embryo 18-20hr    6532 embryo 20-22hr    4919 embryo 22-24hr    4970 larva L1    5737 larva L2    5249 larva L3 12hr old    3918 larva L3 puffstage 1-2    2886 larva L3 puffstage 3-6    3442 larva L3 puffstage 7-9    3786 white prepupae new    4245 white prepupae 12hr    9057 white prepupae 24hr    5648 pupae 2d postWPP    4263 pupae 3d postWPP    3101 pupae 4d postWPP    2152 adult male 01day    1898 adult male 05day    2145 adult male 30day    2668 adult female 01day    2177 adult female 05day    1624 adult female 30day    1855 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1703) embryo 02-04hr  (2012) embryo 04-06hr  (2581) embryo 06-08hr  (4942) embryo 08-10hr  (6202) embryo 10-12hr  (7124) embryo 12-14hr  (5634) embryo 14-16hr  (6045) embryo 16-18hr  (6179) embryo 18-20hr  (6532) embryo 20-22hr  (4919) embryo 22-24hr  (4970) larva L1  (5737) larva L2  (5249) larva L3 12hr old  (3918) larva L3 puffstage 1-2  (2886) larva L3 puffstage 3-6  (3442) larva L3 puffstage 7-9  (3786) white prepupae new  (4245) white prepupae 12hr  (9057) white prepupae 24hr  (5648) pupae 2d postWPP  (4263) pupae 3d postWPP  (3101) pupae 4d postWPP  (2152) adult male 01day  (1898) adult male 05day  (2145) adult male 30day  (2668) adult female 01day  (2177) adult female 05day  (1624) adult female 30day  (1855) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1703) embryo 02-04hr  (2012) embryo 04-06hr  (2581) embryo 06-08hr  (4942) embryo 08-10hr  (6202) embryo 10-12hr  (7124) embryo 12-14hr  (5634) embryo 14-16hr  (6045) embryo 16-18hr  (6179) embryo 18-20hr  (6532) embryo 20-22hr  (4919) embryo 22-24hr  (4970) larva L1  (5737) larva L2  (5249) larva L3 12hr old  (3918) larva L3 puffstage 1-2  (2886) larva L3 puffstage 3-6  (3442) larva L3 puffstage 7-9  (3786) white prepupae new  (4245) white prepupae 12hr  (9057) white prepupae 24hr  (5648) pupae 2d postWPP  (4263) pupae 3d postWPP  (3101) pupae 4d postWPP  (2152) adult male 01day  (1898) adult male 05day  (2145) adult male 30day  (2668) adult female 01day  (2177) adult female 05day  (1624) adult female 30day  (1855) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1703 embryo 02-04hr    2012 embryo 04-06hr    2581 embryo 06-08hr    4942 embryo 08-10hr    6202 embryo 10-12hr    7124 embryo 12-14hr    5634 embryo 14-16hr    6045 embryo 16-18hr    6179 embryo 18-20hr    6532 embryo 20-22hr    4919 embryo 22-24hr    4970 larva L1    5737 larva L2    5249 larva L3 12hr old    3918 larva L3 puffstage 1-2    2886 larva L3 puffstage 3-6    3442 larva L3 puffstage 7-9    3786 white prepupae new    4245 white prepupae 12hr    9057 white prepupae 24hr    5648 pupae 2d postWPP    4263 pupae 3d postWPP    3101 pupae 4d postWPP    2152 adult male 01day    1898 adult male 05day    2145 adult male 30day    2668 adult female 01day    2177 adult female 05day    1624 adult female 30day    1855 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1703 embryo 02-04hr    2012 embryo 04-06hr    2581 embryo 06-08hr    4942 embryo 08-10hr    6202 embryo 10-12hr    7124 embryo 12-14hr    5634 embryo 14-16hr    6045 embryo 16-18hr    6179 embryo 18-20hr    6532 embryo 20-22hr    4919 embryo 22-24hr    4970 larva L1    5737 larva L2    5249 larva L3 12hr old    3918 larva L3 puffstage 1-2    2886 larva L3 puffstage 3-6    3442 larva L3 puffstage 7-9    3786 white prepupae new    4245 white prepupae 12hr    9057 white prepupae 24hr    5648 pupae 2d postWPP    4263 pupae 3d postWPP    3101 pupae 4d postWPP    2152 adult male 01day    1898 adult male 05day    2145 adult male 30day    2668 adult female 01day    2177 adult female 05day    1624 adult female 30day    1855 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030749 expression level Developmental Stage   Expression Level embryo 00-02hr    1703 embryo 02-04hr    2012 embryo 04-06hr    2581 embryo 06-08hr    4942 embryo 08-10hr    6202 embryo 10-12hr    7124 embryo 12-14hr    5634 embryo 14-16hr    6045 embryo 16-18hr    6179 embryo 18-20hr    6532 embryo 20-22hr    4919 embryo 22-24hr    4970 larva L1    5737 larva L2    5249 larva L3 12hr old    3918 larva L3 puffstage 1-2    2886 larva L3 puffstage 3-6    3442 larva L3 puffstage 7-9    3786 white prepupae new    4245 white prepupae 12hr    9057 white prepupae 24hr    5648 pupae 2d postWPP    4263 pupae 3d postWPP    3101 pupae 4d postWPP    2152 adult male 01day    1898 adult male 05day    2145 adult male 30day    2668 adult female 01day    2177 adult female 05day    1624 adult female 30day    1855 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1703) embryo 02-04hr  (2012) embryo 04-06hr  (2581) embryo 06-08hr  (4942) embryo 08-10hr  (6202) embryo 10-12hr  (7124) embryo 12-14hr  (5634) embryo 14-16hr  (6045) embryo 16-18hr  (6179) embryo 18-20hr  (6532) embryo 20-22hr  (4919) embryo 22-24hr  (4970) larva L1  (5737) larva L2  (5249) larva L3 12hr old  (3918) larva L3 puffstage 1-2  (2886) larva L3 puffstage 3-6  (3442) larva L3 puffstage 7-9  (3786) white prepupae new  (4245) white prepupae 12hr  (9057) white prepupae 24hr  (5648) pupae 2d postWPP  (4263) pupae 3d postWPP  (3101) pupae 4d postWPP  (2152) adult male 01day  (1898) adult male 05day  (2145) adult male 30day  (2668) adult female 01day  (2177) adult female 05day  (1624) adult female 30day  (1855) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1703 embryo 02-04hr  2012 embryo 04-06hr  (2581) embryo 06-08hr  (4942) embryo 08-10hr  (6202) embryo 10-12hr  (7124) embryo 12-14hr  (5634) embryo 14-16hr  (6045) embryo 16-18hr  (6179) embryo 18-20hr  (6532) embryo 20-22hr  (4919) embryo 22-24hr  (4970) larva L1  (5737) larva L2  (5249) larva L3 12hr old  (3918) larva L3 puffstage 1-2  (2886) larva L3 puffstage 3-6  (3442) larva L3 puffstage 7-9  (3786) white prepupae new  (4245) white prepupae 12hr  (9057) white prepupae 24hr  (5648) pupae 2d postWPP  (4263) pupae 3d postWPP  (3101) pupae 4d postWPP  2152 adult male 01day  1898 adult male 05day  2145 adult male 30day  (2668) adult female 01day  2177 adult female 05day  1624 adult female 30day  1855 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1703 embryo 02-04hr    2012 embryo 04-06hr    2581 embryo 06-08hr    4942 embryo 08-10hr    6202 embryo 10-12hr    7124 embryo 12-14hr    5634 embryo 14-16hr    6045 embryo 16-18hr    6179 embryo 18-20hr    6532 embryo 20-22hr    4919 embryo 22-24hr    4970 larva L1    5737 larva L2    5249 larva L3 12hr old    3918 larva L3 puffstage 1-2    2886 larva L3 puffstage 3-6    3442 larva L3 puffstage 7-9    3786 white prepupae new    4245 white prepupae 12hr    9057 white prepupae 24hr    5648 pupae 2d postWPP    4263 pupae 3d postWPP    3101 pupae 4d postWPP    2152 adult male 01day    1898 adult male 05day    2145 adult male 30day    2668 adult female 01day    2177 adult female 05day    1624 adult female 30day    1855 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1703 embryo 02-04hr    2012 embryo 04-06hr    2581 embryo 06-08hr    4942 embryo 08-10hr    6202 embryo 10-12hr    7124 embryo 12-14hr    5634 embryo 14-16hr    6045 embryo 16-18hr    6179 embryo 18-20hr    6532 embryo 20-22hr    4919 embryo 22-24hr    4970 larva L1    5737 larva L2    5249 larva L3 12hr old    3918 larva L3 puffstage 1-2    2886 larva L3 puffstage 3-6    3442 larva L3 puffstage 7-9    3786 white prepupae new    4245 white prepupae 12hr    9057 white prepupae 24hr    5648 pupae 2d postWPP    4263 pupae 3d postWPP    3101 pupae 4d postWPP    2152 adult male 01day    1898 adult male 05day    2145 adult male 30day    2668 adult female 01day    2177 adult female 05day    1624 adult female 30day    1855 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030749    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030749 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult female reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030749 expression level Tissue   Expression Level Larval Central Nervous System    535.325 Larval Midgut    157.5 Larval Hindgut    795.1 Larval Malpighian Tubules    651.2 Larval Fat Body    648.5 Larval Salivary Gland    1037.4 Larval Trachea    555.325 Larval Carcass    655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland    1453.5 Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland    1691.1 Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  535.325 Larval Midgut    157.5 Larval Hindgut  (795.1) Larval Malpighian Tubules  (651.2) Larval Fat Body  (648.5) Larval Salivary Gland  (1037.4) Larval Trachea  (555.325) Larval Carcass  (655.65) Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland  (1453.5) Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland  (1691.1) Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    535.325 Larval Midgut    157.5 Larval Hindgut    795.1 Larval Malpighian Tubules    651.2 Larval Fat Body    648.5 Larval Salivary Gland  1037.4 Larval Trachea    555.325 Larval Carcass    655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland  (1453.5) Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland  (1691.1) Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    535.325 Larval Midgut    157.5 Larval Hindgut    795.1 Larval Malpighian Tubules    651.2 Larval Fat Body    648.5 Larval Salivary Gland    1037.4 Larval Trachea    555.325 Larval Carcass    655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland    1453.5 Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland    1691.1 Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030749 expression level Tissue   Expression Level Larval Central Nervous System    535.325 Larval Midgut    157.5 Larval Hindgut    795.1 Larval Malpighian Tubules    651.2 Larval Fat Body    648.5 Larval Salivary Gland    1037.4 Larval Trachea    555.325 Larval Carcass    655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland    1453.5 Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland    1691.1 Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  535.325 Larval Midgut    157.5 Larval Hindgut  795.1 Larval Malpighian Tubules  651.2 Larval Fat Body  648.5 Larval Salivary Gland  (1037.4) Larval Trachea  555.325 Larval Carcass  655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland  (1453.5) Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland  (1691.1) Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    535.325 Larval Midgut    157.5 Larval Hindgut    795.1 Larval Malpighian Tubules    651.2 Larval Fat Body    648.5 Larval Salivary Gland  1037.4 Larval Trachea    555.325 Larval Carcass    655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland  1453.5 Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland  1691.1 Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    535.325 Larval Midgut    157.5 Larval Hindgut    795.1 Larval Malpighian Tubules    651.2 Larval Fat Body    648.5 Larval Salivary Gland    1037.4 Larval Trachea    555.325 Larval Carcass    655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland    1453.5 Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland    1691.1 Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    422.8   NA  Eye    314.875   NA  Brain    222   535.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    272.7   NA  Crop    485.7   157.5  Midgut    217.9   795.1  Hindgut    489.7   651.2  Malpighian Tubules    368.8   648.5  Fat Body    416.4   1037.4  Salivary Gland    1453.5   NA  Heart    242.15   555.325  Trachea    NA   NA  VirginFemale Spermatheca    397.6   NA  InseminatedFemale Spermatheca    426.2   NA  Ovary    251.3   NA  Testis    96.9   NA  Male Accessory Gland    1691.1   655.65  Carcass    295.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030749 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9968-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Anxb11 Stages(s) 1-3 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Anxb11GD14328 viable, with Scer\GAL4pnr-MD237 Anxb11GD15109 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Anxb11 Class Mutagen Stocks Known lesion Anxb11MI01310 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Anxb11 Class Mutagen Stocks Known lesion Anxb11GD14328 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Anxb11GD15109 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Anxb11KK107526 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14328} NA P{GD15109} NA P{KK107526} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Anxb11MI01310 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data on: 2006-10-26)
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell adhesion inferred from mutant phenotype (Kiger et al., 2003) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) calcium-dependent phospholipid binding inferred from electronic annotation with InterPro:IPR001464, InterPro:IPR018252, InterPro:IPR018502 (FlyBase Curators et al., 2004-) non-traceable author statement (Fernandez, 2000.3.29) calcium ion binding inferred from electronic annotation with InterPro:IPR001464, InterPro:IPR018252, InterPro:IPR018502 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Anxb11 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58952 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030749 DroID - A comprehensive database of gene and protein interactions. • FBgn0030749 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32612
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19282 Dere\GG19323 Dgri\GH12030 Dmoj\GI14303 Dper\GL15887 Dpse\GA22156 Dsec\GM13401 Dsim\GD15750 Dvir\GJ19360 Dwil\GK25708 Dyak\GE15970
Curated drosophilid orthologs	Dpse\GA22156
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_623349.1 Apis mellifera (honey bee) XP_001950997.1 Acyrthosiphon pisum (pea aphid) At1g68090.1 Arabidopsis thaliana (wall cress) At5g10220.1 Arabidopsis thaliana (wall cress) XP_001894032.1 Brugia malayi (roundworm nematode) BGIBMGA002773-PA Bombyx mori (silk worm) ENSBTAP00000046882 Bos taurus (bovine) CN18303 Caenorhabditis brenneri (small nematode) CBP12960 Caenorhabditis briggsae (nematode) CE23956 Caenorhabditis elegans (worm) ENSCAFP00000030525 Canis familiaris (dog) ENSCINP00000008762 Ciona intestinalis (sea squirt) JA09349 Caenorhabditis japonica (nematode) cn05139 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000002314 Cavia porcellus (guinea pig) ENSCSAVP00000001260 Ciona savignyi (sedentary tunicate) 226167 Capitella spl (polychaete worm) DDB0232009 Dictyostelium discoideum (amoeba) 305145 Daphnia pulex (daphnia) ENSDARP00000057947 Danio rerio (zebra fish) ENSECAP00000011553 Equus caballus (horse) ENSGACP00000002962 Gymnopilus aculeatus (mushroom) ENSGALP00000008485 Gallus gallus (chicken) GL50803_4026 Giardia lamblia (flagellated protozoan) 99776 Hypsipyla robusta (cedar shoot borer) ENSP00000378317 Homo sapiens (human) ENSMODP00000000243 Monodelphis domestica (gray opossum) ENSMMUP00000035849 Macaca mulatta (rhesus monkey) ENSMUSP00000066035 Mus musculus (house mouse) 134949 Nematostella vectensis (starlet anemone) ENSOANP00000000540 Ornithorynchus anatinus (platypus) ENSORLP00000011129 Oryzias latipes (japanese killifish) LOC_Os09g23160.1 Oryza sativa (asian rice) PHUM003791-PA Pediculus humanus (human body louse) PP13350 Pristionchus pacificus (nematode) ENSPPYP00000002713 Pongo pygmaeus (orangutan) 72219 Phytophthora ramorum (sudden oak death pathogen) 72404 Phytophthora ramorum (sudden oak death pathogen) 72422 Phytophthora ramorum (sudden oak death pathogen) 569376 Populus trichocarpa (black cottonwood) ENSPTRP00000056473 Pan troglodytes (chimpanzee) ENSRNOP00000010011 Rattus norvegicus (norway rat) 4747874 Sorghum bicolor (sorghum) XP_001186213.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967143.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011477 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000016137 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000016138 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000035499 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000056574 Xenopus tropicalis (frog) YALI0D08338g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13641 NV14241 LH20935 LH23448 ISCW022221 FBgn0233526 FBgn0227667 FBgn0216186 FBgn0206503 FBgn0198275 FBgn0190894 FBgn0187411 FBgn0169981 FBgn0168332 JGI_V11_44209 JGI_V11_308684 JGI_V11_302630 JGI_V11_305145 JGI_V11_68257 FBgn0082135 FBgn0079088 FBgn0153491 FBgn0149548 FBgn0145174 FBgn0137056 FBgn0000083 FBgn0124793 FBgn0119509 FBgn0116453 FBgn0111527 FBgn0096293 FBgn0093514 CPIJ001340 CPIJ018013 BGIBMGA010130 BGIBMGA002773 ACYPI009502 ACYPI002346 GB16312 ANXB9 AGAP012930 AAEL011302 PB25749 PHUM014750 PHUM211460 GLEAN_11793 GLEAN_11792 GLEAN_11791 GLEAN_10520
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	34420 y1 w* Mi{MIC}Anxb11MI01310
VDRC	v101313 P{KK107526}VIE-260B v29693 w1118; P{GD15109}v29693 v36185 w1118; P{GD14328}v36185 v36186 w1118; P{GD14328}v36186
Genomic Clones ( 2 )
	BACR13G13 BACR47D09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 72 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH16395 GM13766
Other clones	DPiM_GM13766 LD19596
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05676 GH26271 LD16837 RE03488 RE06101 RE15943 RE16062 RE17116 RE20671 RE28852 RE29846 RE30369 RE30682 RE34869 RE39231 RE40966 RE42476 RE52631 RE54515 RE59460 RE60279 RE60412 RE67203 RE68475 RE70487 RH59331 RH72116
Other clones	357 7818 44009 61215 102907 104287 120403 120567 214219.28 274653 bs79b04 CK01.70D.B12 CK01.119B.E1 EK056240 EK057202 EK091017 EK105347 EK105926 EK160235 EK165333 EK173543 EK176950 EK181402 EK184754 EK224751 EK240315 EK249109 EK302462 EP04644 EP08907 EP14161 EP16837 ESG012c.E21_F03 ESG015b.E21_H09 ESG0111b.B21.1_E04 ESG0112c.B21.1_D10 FGM103H12 FGM214B03 FGM306H11 RP003054069 UUGC0148
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030749 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32612
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Anxb11 CG9968 (FlyBase, 1996-)
Source for database merge of	Source for merge of: Anxb11 BcDNA:GH16395 (FlyBase, 1996-)
Additional comments	Source for merge of Anxb11 BcDNA:GH16395 was TrEMBL update (date:020807). (FlyBase, 1996-) Source for identity of Anxb11 CG9968 was sequence comparison (date:000407). (FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078646 NM_167519 RefSeq (Proteins) • NP_523370 NP_727978 DDBJ / EMBL / GenBank • AA803645 AAF48609 AAF48610 AAL13626 AAM52650 AI293253 AJ276963 AW940623 AY058397 AY122138 CAB86189 Entrez Gene - A searchable database of RefSeq genes. • 32612 UniProtKB/TrEMBL • Q9VXG3 Q9VXG4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Annexin (IPR001464) Annexin repeat, conserved site (IPR018252) Annexin repeat (IPR018502)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58952 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030749 DroID - A comprehensive database of gene and protein interactions. • FBgn0030749 DRSC - Results from RNAi screens. • FBgn0030749 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030749 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9968-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030749 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32612 InParanoid A subset of ortholog calls from InParanoid. • XP_623349.1 Apis mellifera (honey bee) XP_001950997.1 Acyrthosiphon pisum (pea aphid) At1g68090.1 Arabidopsis thaliana (wall cress) At5g10220.1 Arabidopsis thaliana (wall cress) XP_001894032.1 Brugia malayi (roundworm nematode) BGIBMGA002773-PA Bombyx mori (silk worm) ENSBTAP00000046882 Bos taurus (bovine) CN18303 Caenorhabditis brenneri (small nematode) CBP12960 Caenorhabditis briggsae (nematode) CE23956 Caenorhabditis elegans (worm) ENSCAFP00000030525 Canis familiaris (dog) ENSCINP00000008762 Ciona intestinalis (sea squirt) JA09349 Caenorhabditis japonica (nematode) cn05139 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000002314 Cavia porcellus (guinea pig) ENSCSAVP00000001260 Ciona savignyi (sedentary tunicate) 226167 Capitella spl (polychaete worm) DDB0232009 Dictyostelium discoideum (amoeba) 305145 Daphnia pulex (daphnia) ENSDARP00000057947 Danio rerio (zebra fish) ENSECAP00000011553 Equus caballus (horse) ENSGACP00000002962 Gymnopilus aculeatus (mushroom) ENSGALP00000008485 Gallus gallus (chicken) GL50803_4026 Giardia lamblia (flagellated protozoan) 99776 Hypsipyla robusta (cedar shoot borer) ENSP00000378317 Homo sapiens (human) ENSMODP00000000243 Monodelphis domestica (gray opossum) ENSMMUP00000035849 Macaca mulatta (rhesus monkey) ENSMUSP00000066035 Mus musculus (house mouse) 134949 Nematostella vectensis (starlet anemone) ENSOANP00000000540 Ornithorynchus anatinus (platypus) ENSORLP00000011129 Oryzias latipes (japanese killifish) LOC_Os09g23160.1 Oryza sativa (asian rice) PHUM003791-PA Pediculus humanus (human body louse) PP13350 Pristionchus pacificus (nematode) ENSPPYP00000002713 Pongo pygmaeus (orangutan) 72219 Phytophthora ramorum (sudden oak death pathogen) 72404 Phytophthora ramorum (sudden oak death pathogen) 72422 Phytophthora ramorum (sudden oak death pathogen) 569376 Populus trichocarpa (black cottonwood) ENSPTRP00000056473 Pan troglodytes (chimpanzee) ENSRNOP00000010011 Rattus norvegicus (norway rat) 4747874 Sorghum bicolor (sorghum) XP_001186213.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967143.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011477 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000016137 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000016138 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000035499 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000056574 Xenopus tropicalis (frog) YALI0D08338g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32612 modMine - Data generated by the modENCODE project. • FBgn0030749 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13641 NV14241 LH20935 LH23448 ISCW022221 FBgn0233526 FBgn0227667 FBgn0216186 FBgn0206503 FBgn0198275 FBgn0190894 FBgn0187411 FBgn0169981 FBgn0168332 JGI_V11_44209 JGI_V11_308684 JGI_V11_302630 JGI_V11_305145 JGI_V11_68257 FBgn0082135 FBgn0079088 FBgn0153491 FBgn0149548 FBgn0145174 FBgn0137056 FBgn0000083 FBgn0124793 FBgn0119509 FBgn0116453 FBgn0111527 FBgn0096293 FBgn0093514 CPIJ001340 CPIJ018013 BGIBMGA010130 BGIBMGA002773 ACYPI009502 ACYPI002346 GB16312 ANXB9 AGAP012930 AAEL011302 PB25749 PHUM014750 PHUM211460 GLEAN_11793 GLEAN_11792 GLEAN_11791 GLEAN_10520
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	annexin (Löw et al., 2007) Anxb11 (Stuart et al., 2007, Kim et al., 2005, Schnorrer et al., 2010, Curtis et al., 2007) AnxB11 (Stoltzfus and Grotewiel, 2003) BcDNA:GH16395   CG9968 (Goldstein and Gunawardena, 2000, Keleman et al., 2009.8.5, Cammarato et al., 2011)
Name Synonym	Annexin B11 (Fernandez, 2000.3.29, Cammarato et al., 2011) annexin B11 (Jovceva et al., 2007)
Secondary FlyBase IDs
	FBgn0046794
References ( 26 )
Generate a list of	All references relating to this gene ( 26 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Schnorrer et al., 2010, Nature 464(7286): 287--291 Systematic genetic analysis of muscle morphogenesis and function in Drosophila. [FBrf0210226] Show all research papers ...