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Gene Dmel\AnxB11

General Information
Symbol	Dmel\AnxB11	Species	D. melanogaster
Name	Annexin B11	Annotation symbol	CG9968
Feature type	protein_coding_gene	FlyBase ID	FBgn0030749
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	AnxB11
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	14C4-14C4	Sequence location	X:16,310,991..16,316,298 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Annexin B11 is referred to in FlyBase by the symbol Dmel\AnxB11 (CG9968, FBgn0030749). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence that it is involved in the biological process: regulation of cell shape; cell adhesion. 6 alleles are reported. No phenotypic data is available. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Annexin; Annexin repeat; Annexin repeat, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult female reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625145_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Anxb11. Gene sequence location is X:16310991..16316298.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 14C4-14C4   Limits computationally determined from genome sequence between P{EP}EP1493EP1493 and P{EP}EP1547EP1547
Experimentally Determined Cytological Location
Cytogenetic map Notes References 14C6-14C6     (Fernandez, 2000.3.29)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\AnxB11 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) AnxB11-RA FBtr0074302  NM_078646   1233   322 AnxB11-RB FBtr0074303  NM_167519   1731   511 AnxB11-RC FBtr0334038  NM_001272685   1429   322 AnxB11-RD FBtr0334039  NM_001272686   1905   295 AnxB11-RE FBtr0334040  NM_001272687   2485   511 AnxB11-RF FBtr0334041  NM_001272688   1375   322 AnxB11-RG FBtr0334042  NM_001272689   2927   511
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein AnxB11-PA   FBpp0074077   36.3   322   6.41     NP_523370   AAF48610 AnxB11-PB   FBpp0074078   56.2   511   7.15     NP_727978   AAF48609 AnxB11-PC   FBpp0306154   36.3   322   6.41     NP_001259614   AGB95456 AnxB11-PD   FBpp0306155   33.4   295   6.27     NP_001259615   AGB95457 AnxB11-PE   FBpp0306156   56.2   511   7.15     NP_001259616   AGB95458 AnxB11-PF   FBpp0306157   36.3   322   6.41     NP_001259617   AGB95459 AnxB11-PG   FBpp0306158   56.2   511   7.15     NP_001259618   AGB95460
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Annexin (IPR001464) Annexin repeat, conserved site (IPR018252) Annexin repeat (IPR018502)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA536304   AA803645   AE014298 AAF48609   AE014298 AAF48610   AE014298 AGB95456   AE014298 AGB95457   AE014298 AGB95458   AE014298 AGB95459   AE014298 AGB95460   AI107820   AI293253   AI406093   AJ276963 CAB86189   AW940623   AY058397 AAL13626   AY122138 AAM52650   BE978546   BI163953   BI166075   BI173181   BI173274   BI173960   BI214679   BI232731   BI234187   BI234636   BI234910   BI238415   BI242017   BI243355   BI356355   BI366973   BI368529   BI372487   BI373067   BI373180   BI484146   BI485188   BI486995   BI606036   BI630313   BP549867   BP549868   BP551663   BP551664   BP557034   BP557035   BQ102763   BT125828   CA803935   CA804213   CA806283   CA806886   CO178257   CO178613   CO268329   CO271974   CO272119   CO282330   CO284133   CO298706   CO299944   CO301550   CO302718   CO303154   CO305614   CO311511   CO326796   CO328278   CO332084   CO342221   CO343471   EC062981   EC067767   EC071649   EC077026   EC084968   EC088502   EC202444   EC209194   EC230206   EC231577   EC248229   EC257359   GH807767
UniProtKB/Swiss-Prot	Q9VXG4
UniProtKB/TrEMBL	Q9VXG3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 11 -- 12   atrium | precursor   (Fisher et al., 2012) Comment:reported as atrium primordium dorsal epidermis primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) embryonic anal pad   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012) embryonic large intestine   (Fisher et al., 2012) embryonic/larval salivary gland   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult female reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    535.325 Larval Midgut    157.5 Larval Hindgut    795.1 Larval Malpighian Tubules    651.2 Larval Fat Body    648.5 Larval Salivary Gland    1037.4 Larval Trachea    555.325 Larval Carcass    655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland    1453.5 Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland    1691.1 Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  535.325 Larval Midgut    157.5 Larval Hindgut  (795.1) Larval Malpighian Tubules  (651.2) Larval Fat Body  (648.5) Larval Salivary Gland  (1037.4) Larval Trachea  (555.325) Larval Carcass  (655.65) Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland  (1453.5) Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland  (1691.1) Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    535.325 Larval Midgut    157.5 Larval Hindgut    795.1 Larval Malpighian Tubules    651.2 Larval Fat Body    648.5 Larval Salivary Gland  1037.4 Larval Trachea    555.325 Larval Carcass    655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland  (1453.5) Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland  (1691.1) Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    535.325 Larval Midgut    157.5 Larval Hindgut    795.1 Larval Malpighian Tubules    651.2 Larval Fat Body    648.5 Larval Salivary Gland    1037.4 Larval Trachea    555.325 Larval Carcass    655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland    1453.5 Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland    1691.1 Adult Carcass    295.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    535.325 Larval Midgut    157.5 Larval Hindgut    795.1 Larval Malpighian Tubules    651.2 Larval Fat Body    648.5 Larval Salivary Gland    1037.4 Larval Trachea    555.325 Larval Carcass    655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland    1453.5 Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland    1691.1 Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  535.325 Larval Midgut    157.5 Larval Hindgut  795.1 Larval Malpighian Tubules  651.2 Larval Fat Body  648.5 Larval Salivary Gland  (1037.4) Larval Trachea  555.325 Larval Carcass  655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland  (1453.5) Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland  (1691.1) Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    535.325 Larval Midgut    157.5 Larval Hindgut    795.1 Larval Malpighian Tubules    651.2 Larval Fat Body    648.5 Larval Salivary Gland  1037.4 Larval Trachea    555.325 Larval Carcass    655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland  1453.5 Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland  1691.1 Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    535.325 Larval Midgut    157.5 Larval Hindgut    795.1 Larval Malpighian Tubules    651.2 Larval Fat Body    648.5 Larval Salivary Gland    1037.4 Larval Trachea    555.325 Larval Carcass    655.65 Adult Head    422.8 Adult Eye    314.875 Adult Brain    222 Adult Thoracic-Abdominal Ganglion    272.7 Adult Crop    485.7 Adult Midgut    217.9 Adult Hindgut    489.7 Adult Malpighian Tubules    368.8 Adult Fat Body    416.4 Adult Salivary Gland    1453.5 Adult Heart    242.15 Adult VirginFemale Spermatheca    397.6 Adult InseminatedFemale Spermatheca    426.2 Adult Ovary    251.3 Adult Testis    96.9 Adult Male Accessory Gland    1691.1 Adult Carcass    295.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    422.8   NA  Eye    314.875   NA  Brain    222   535.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    272.7   NA  Crop    485.7   157.5  Midgut    217.9   795.1  Hindgut    489.7   651.2  Malpighian Tubules    368.8   648.5  Fat Body    416.4   1037.4  Salivary Gland    1453.5   NA  Heart    242.15   555.325  Trachea    NA   NA  VirginFemale Spermatheca    397.6   NA  InseminatedFemale Spermatheca    426.2   NA  Ovary    251.3   NA  Testis    96.9   NA  Male Accessory Gland    1691.1   655.65  Carcass    295.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    35 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    18 head, virgin 20-day female    21 head, mated 1-day female    21 head, mated 4-day female    18 head, mated 20-day female    19 head, mated 1-day male    18 head, mated 4-day male    23 head, mated 20-day male    31 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    88 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    22 fat body, white prepupae    29 fat body, pupae P8    66 carcass, larvae L3 wandering    32 carcass, 1-day adult    19 carcass, 4-day adult    19 carcass, 20-day adult    23 ovary, virgin 4-day female    10 ovary, mated 4-day female    12 testis, mated 4-day male    25 accessory gland, mated 4-day male    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (35) central nervous system, larvae L3  (35) central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    18 head, virgin 20-day female    21 head, mated 1-day female    21 head, mated 4-day female    18 head, mated 20-day female    19 head, mated 1-day male    18 head, mated 4-day male    23 head, mated 20-day male  (31) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (88) digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    22 fat body, white prepupae  (29) fat body, pupae P8  (66) carcass, larvae L3 wandering  (32) carcass, 1-day adult    19 carcass, 4-day adult    19 carcass, 20-day adult    23 ovary, virgin 4-day female    10 ovary, mated 4-day female    12 testis, mated 4-day male    25 accessory gland, mated 4-day male  (78) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    35 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    18 head, virgin 20-day female    21 head, mated 1-day female    21 head, mated 4-day female    18 head, mated 20-day female    19 head, mated 1-day male    18 head, mated 4-day male    23 head, mated 20-day male    31 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    88 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    22 fat body, white prepupae    29 fat body, pupae P8    66 carcass, larvae L3 wandering    32 carcass, 1-day adult    19 carcass, 4-day adult    19 carcass, 20-day adult    23 ovary, virgin 4-day female    10 ovary, mated 4-day female    12 testis, mated 4-day male    25 accessory gland, mated 4-day male    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    35 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    18 head, virgin 20-day female    21 head, mated 1-day female    21 head, mated 4-day female    18 head, mated 20-day female    19 head, mated 1-day male    18 head, mated 4-day male    23 head, mated 20-day male    31 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    88 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    22 fat body, white prepupae    29 fat body, pupae P8    66 carcass, larvae L3 wandering    32 carcass, 1-day adult    19 carcass, 4-day adult    19 carcass, 20-day adult    23 ovary, virgin 4-day female    10 ovary, mated 4-day female    12 testis, mated 4-day male    25 accessory gland, mated 4-day male    78 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    35 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    18 head, virgin 20-day female    21 head, mated 1-day female    21 head, mated 4-day female    18 head, mated 20-day female    19 head, mated 1-day male    18 head, mated 4-day male    23 head, mated 20-day male    31 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    88 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    22 fat body, white prepupae    29 fat body, pupae P8    66 carcass, larvae L3 wandering    32 carcass, 1-day adult    19 carcass, 4-day adult    19 carcass, 20-day adult    23 ovary, virgin 4-day female    10 ovary, mated 4-day female    12 testis, mated 4-day male    25 accessory gland, mated 4-day male    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (35) central nervous system, larvae L3  (35) central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    18 head, virgin 20-day female    21 head, mated 1-day female    21 head, mated 4-day female    18 head, mated 20-day female    19 head, mated 1-day male    18 head, mated 4-day male    23 head, mated 20-day male  31 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (88) digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    22 fat body, white prepupae  29 fat body, pupae P8  (66) carcass, larvae L3 wandering  32 carcass, 1-day adult    19 carcass, 4-day adult    19 carcass, 20-day adult    23 ovary, virgin 4-day female    10 ovary, mated 4-day female    12 testis, mated 4-day male    25 accessory gland, mated 4-day male  (78) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    35 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    18 head, virgin 20-day female    21 head, mated 1-day female    21 head, mated 4-day female    18 head, mated 20-day female    19 head, mated 1-day male    18 head, mated 4-day male    23 head, mated 20-day male    31 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    88 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    22 fat body, white prepupae    29 fat body, pupae P8    66 carcass, larvae L3 wandering    32 carcass, 1-day adult    19 carcass, 4-day adult    19 carcass, 20-day adult    23 ovary, virgin 4-day female    10 ovary, mated 4-day female    12 testis, mated 4-day male    25 accessory gland, mated 4-day male    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    35 central nervous system, larvae L3    35 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    18 head, virgin 20-day female    21 head, mated 1-day female    21 head, mated 4-day female    18 head, mated 20-day female    19 head, mated 1-day male    18 head, mated 4-day male    23 head, mated 20-day male    31 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    88 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    22 fat body, white prepupae    29 fat body, pupae P8    66 carcass, larvae L3 wandering    32 carcass, 1-day adult    19 carcass, 4-day adult    19 carcass, 20-day adult    23 ovary, virgin 4-day female    10 ovary, mated 4-day female    12 testis, mated 4-day male    25 accessory gland, mated 4-day male    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    28 embryo 06-08hr    53 embryo 08-10hr    66 embryo 10-12hr    76 embryo 12-14hr    60 embryo 14-16hr    64 embryo 16-18hr    66 embryo 18-20hr    69 embryo 20-22hr    52 embryo 22-24hr    53 larva L1    61 larva L2    56 larva L3 12hr old    42 larva L3 puffstage 1-2    31 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    40 white prepupae new    45 white prepupae 12hr    97 white prepupae 24hr    60 pupae 2d postWPP    46 pupae 3d postWPP    33 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    23 adult male 30day    28 adult female 01day    23 adult female 05day    17 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr  (28) embryo 06-08hr  (53) embryo 08-10hr  (66) embryo 10-12hr  (76) embryo 12-14hr  (60) embryo 14-16hr  (64) embryo 16-18hr  (66) embryo 18-20hr  (69) embryo 20-22hr  (52) embryo 22-24hr  (53) larva L1  (61) larva L2  (56) larva L3 12hr old  (42) larva L3 puffstage 1-2  (31) larva L3 puffstage 3-6  (37) larva L3 puffstage 7-9  (40) white prepupae new  (45) white prepupae 12hr  (97) white prepupae 24hr  (60) pupae 2d postWPP  (46) pupae 3d postWPP  (33) pupae 4d postWPP    23 adult male 01day    20 adult male 05day    23 adult male 30day  (28) adult female 01day    23 adult female 05day    17 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    28 embryo 06-08hr    53 embryo 08-10hr    66 embryo 10-12hr    76 embryo 12-14hr    60 embryo 14-16hr    64 embryo 16-18hr    66 embryo 18-20hr    69 embryo 20-22hr    52 embryo 22-24hr    53 larva L1    61 larva L2    56 larva L3 12hr old    42 larva L3 puffstage 1-2    31 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    40 white prepupae new    45 white prepupae 12hr    97 white prepupae 24hr    60 pupae 2d postWPP    46 pupae 3d postWPP    33 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    23 adult male 30day    28 adult female 01day    23 adult female 05day    17 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    28 embryo 06-08hr    53 embryo 08-10hr    66 embryo 10-12hr    76 embryo 12-14hr    60 embryo 14-16hr    64 embryo 16-18hr    66 embryo 18-20hr    69 embryo 20-22hr    52 embryo 22-24hr    53 larva L1    61 larva L2    56 larva L3 12hr old    42 larva L3 puffstage 1-2    31 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    40 white prepupae new    45 white prepupae 12hr    97 white prepupae 24hr    60 pupae 2d postWPP    46 pupae 3d postWPP    33 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    23 adult male 30day    28 adult female 01day    23 adult female 05day    17 adult female 30day    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    28 embryo 06-08hr    53 embryo 08-10hr    66 embryo 10-12hr    76 embryo 12-14hr    60 embryo 14-16hr    64 embryo 16-18hr    66 embryo 18-20hr    69 embryo 20-22hr    52 embryo 22-24hr    53 larva L1    61 larva L2    56 larva L3 12hr old    42 larva L3 puffstage 1-2    31 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    40 white prepupae new    45 white prepupae 12hr    97 white prepupae 24hr    60 pupae 2d postWPP    46 pupae 3d postWPP    33 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    23 adult male 30day    28 adult female 01day    23 adult female 05day    17 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr  28 embryo 06-08hr  (53) embryo 08-10hr  (66) embryo 10-12hr  (76) embryo 12-14hr  (60) embryo 14-16hr  (64) embryo 16-18hr  (66) embryo 18-20hr  (69) embryo 20-22hr  (52) embryo 22-24hr  (53) larva L1  (61) larva L2  (56) larva L3 12hr old  (42) larva L3 puffstage 1-2  31 larva L3 puffstage 3-6  (37) larva L3 puffstage 7-9  (40) white prepupae new  (45) white prepupae 12hr  (97) white prepupae 24hr  (60) pupae 2d postWPP  (46) pupae 3d postWPP  (33) pupae 4d postWPP    23 adult male 01day    20 adult male 05day    23 adult male 30day  28 adult female 01day    23 adult female 05day    17 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    28 embryo 06-08hr    53 embryo 08-10hr    66 embryo 10-12hr    76 embryo 12-14hr    60 embryo 14-16hr    64 embryo 16-18hr    66 embryo 18-20hr    69 embryo 20-22hr    52 embryo 22-24hr    53 larva L1    61 larva L2    56 larva L3 12hr old    42 larva L3 puffstage 1-2    31 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    40 white prepupae new    45 white prepupae 12hr    97 white prepupae 24hr    60 pupae 2d postWPP    46 pupae 3d postWPP    33 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    23 adult male 30day    28 adult female 01day    23 adult female 05day    17 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    28 embryo 06-08hr    53 embryo 08-10hr    66 embryo 10-12hr    76 embryo 12-14hr    60 embryo 14-16hr    64 embryo 16-18hr    66 embryo 18-20hr    69 embryo 20-22hr    52 embryo 22-24hr    53 larva L1    61 larva L2    56 larva L3 12hr old    42 larva L3 puffstage 1-2    31 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    40 white prepupae new    45 white prepupae 12hr    97 white prepupae 24hr    60 pupae 2d postWPP    46 pupae 3d postWPP    33 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    23 adult male 30day    28 adult female 01day    23 adult female 05day    17 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    125 Schneider line 2 Sg4    135 embryonic 1182-4H    222 embryonic GM2    320 embryonic Kc167    278 embryonic S1    125 embryonic S3    126 leg disc CME L1    210 wing disc CME-W2    216 wing disc ML-DmD8    211 wing disc ML-DmD9    216 wing disc ML-DmD16-c3    250 wing disc ML-DmD21    103 wing disc ML-DmD32    262 haltere disc ML-DmD17-c3    82 eye-antennal disc ML-DmD11    219 antennal disc ML-DmD20-c5    157 mixed discs ML-DmD4-c1    192 CNS ML-DmBG1-c1    155 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    45 ovary fGS/OSS    107 ovary OSC    89 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (125) Schneider line 2 Sg4  (135) embryonic 1182-4H  (222) embryonic GM2  (320) embryonic Kc167  (278) embryonic S1  (125) embryonic S3  (126) leg disc CME L1  (210) wing disc CME-W2  (216) wing disc ML-DmD8  (211) wing disc ML-DmD9  (216) wing disc ML-DmD16-c3  (250) wing disc ML-DmD21  (103) wing disc ML-DmD32  (262) haltere disc ML-DmD17-c3  (82) eye-antennal disc ML-DmD11  (219) antennal disc ML-DmD20-c5  (157) mixed discs ML-DmD4-c1  (192) CNS ML-DmBG1-c1  (155) CNS ML-DmBG2-c2  (48) tumorous blood cells mbn2  (45) ovary fGS/OSS  (107) ovary OSC  (89) ovary OSS  (32) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (125) Schneider line 2 Sg4  (135) embryonic 1182-4H  (222) embryonic GM2  (320) embryonic Kc167  (278) embryonic S1  (125) embryonic S3  (126) leg disc CME L1  (210) wing disc CME-W2  (216) wing disc ML-DmD8  (211) wing disc ML-DmD9  (216) wing disc ML-DmD16-c3  (250) wing disc ML-DmD21  103 wing disc ML-DmD32  (262) haltere disc ML-DmD17-c3    82 eye-antennal disc ML-DmD11  (219) antennal disc ML-DmD20-c5  (157) mixed discs ML-DmD4-c1  (192) CNS ML-DmBG1-c1  (155) CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    45 ovary fGS/OSS  107 ovary OSC    89 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    125 Schneider line 2 Sg4    135 embryonic 1182-4H    222 embryonic GM2    320 embryonic Kc167    278 embryonic S1    125 embryonic S3    126 leg disc CME L1    210 wing disc CME-W2    216 wing disc ML-DmD8    211 wing disc ML-DmD9    216 wing disc ML-DmD16-c3    250 wing disc ML-DmD21    103 wing disc ML-DmD32    262 haltere disc ML-DmD17-c3    82 eye-antennal disc ML-DmD11    219 antennal disc ML-DmD20-c5    157 mixed discs ML-DmD4-c1    192 CNS ML-DmBG1-c1    155 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    45 ovary fGS/OSS    107 ovary OSC    89 ovary OSS    32 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    125 Schneider line 2 Sg4    135 embryonic 1182-4H    222 embryonic GM2    320 embryonic Kc167    278 embryonic S1    125 embryonic S3    126 leg disc CME L1    210 wing disc CME-W2    216 wing disc ML-DmD8    211 wing disc ML-DmD9    216 wing disc ML-DmD16-c3    250 wing disc ML-DmD21    103 wing disc ML-DmD32    262 haltere disc ML-DmD17-c3    82 eye-antennal disc ML-DmD11    219 antennal disc ML-DmD20-c5    157 mixed discs ML-DmD4-c1    192 CNS ML-DmBG1-c1    155 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    45 ovary fGS/OSS    107 ovary OSC    89 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (125) Schneider line 2 Sg4  (135) embryonic 1182-4H  (222) embryonic GM2  (320) embryonic Kc167  (278) embryonic S1  (125) embryonic S3  (126) leg disc CME L1  (210) wing disc CME-W2  (216) wing disc ML-DmD8  (211) wing disc ML-DmD9  (216) wing disc ML-DmD16-c3  (250) wing disc ML-DmD21  (103) wing disc ML-DmD32  (262) haltere disc ML-DmD17-c3  (82) eye-antennal disc ML-DmD11  (219) antennal disc ML-DmD20-c5  (157) mixed discs ML-DmD4-c1  (192) CNS ML-DmBG1-c1  (155) CNS ML-DmBG2-c2  (48) tumorous blood cells mbn2  (45) ovary fGS/OSS  (107) ovary OSC  (89) ovary OSS  32 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  125 Schneider line 2 Sg4  135 embryonic 1182-4H  (222) embryonic GM2  (320) embryonic Kc167  (278) embryonic S1  125 embryonic S3  126 leg disc CME L1  (210) wing disc CME-W2  (216) wing disc ML-DmD8  (211) wing disc ML-DmD9  (216) wing disc ML-DmD16-c3  (250) wing disc ML-DmD21  103 wing disc ML-DmD32  (262) haltere disc ML-DmD17-c3    82 eye-antennal disc ML-DmD11  (219) antennal disc ML-DmD20-c5  (157) mixed discs ML-DmD4-c1  (192) CNS ML-DmBG1-c1  (155) CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    45 ovary fGS/OSS  107 ovary OSC    89 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    125 Schneider line 2 Sg4    135 embryonic 1182-4H    222 embryonic GM2    320 embryonic Kc167    278 embryonic S1    125 embryonic S3    126 leg disc CME L1    210 wing disc CME-W2    216 wing disc ML-DmD8    211 wing disc ML-DmD9    216 wing disc ML-DmD16-c3    250 wing disc ML-DmD21    103 wing disc ML-DmD32    262 haltere disc ML-DmD17-c3    82 eye-antennal disc ML-DmD11    219 antennal disc ML-DmD20-c5    157 mixed discs ML-DmD4-c1    192 CNS ML-DmBG1-c1    155 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    45 ovary fGS/OSS    107 ovary OSC    89 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    18 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    32 Rotenone 8 μg 12 hrs, larvae L3    26 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    18 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3  (30) Cadmium 50 mM 48 hrs, 4-day adult  (30) Cadmium 100 mM 48 hrs, 4-day adult  (42) Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3  26 Zinc 4.5 mM 48 hrs, 4-day adult  (29) Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3  (28) Ethanol 10% 3 hrs, larvae L3  (29) Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult  (30) Rotenone 2 μg 12 hrs, larvae L3  (32) Rotenone 8 μg 12 hrs, larvae L3  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    18 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    32 Rotenone 8 μg 12 hrs, larvae L3    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    18 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    32 Rotenone 8 μg 12 hrs, larvae L3    26 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    18 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    32 Rotenone 8 μg 12 hrs, larvae L3    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    18 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3  30 Cadmium 50 mM 48 hrs, 4-day adult  30 Cadmium 100 mM 48 hrs, 4-day adult  (42) Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3  26 Zinc 4.5 mM 48 hrs, 4-day adult  29 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3  28 Ethanol 10% 3 hrs, larvae L3  29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult  30 Rotenone 2 μg 12 hrs, larvae L3  32 Rotenone 8 μg 12 hrs, larvae L3  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    18 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    32 Rotenone 8 μg 12 hrs, larvae L3    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    18 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    32 Rotenone 8 μg 12 hrs, larvae L3    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • GM13766 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030749 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9968-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for AnxB11 Stages(s) 1-3 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 AnxB11GD14328 viable, with Scer\GAL4pnr-MD237 AnxB11GD15109 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of AnxB11 Class Mutagen Stocks Known lesion AnxB11MI01310 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of AnxB11 Class Mutagen Stocks Known lesion AnxB11GD14328 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes AnxB11GD15109 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AnxB11HMS01775 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AnxB11KK107526 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AnxB11NIG.9968R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}AnxB11MI01310 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data on: 2013-03-07)
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell adhesion inferred from mutant phenotype (Kiger et al., 2003) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) calcium-dependent phospholipid binding inferred from electronic annotation with InterPro:IPR001464, InterPro:IPR018252, InterPro:IPR018502 (FlyBase Curators et al., 2004-) non-traceable author statement (Fernandez, 2000.3.29) calcium ion binding inferred from electronic annotation with InterPro:IPR001464, InterPro:IPR018252, InterPro:IPR018502 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
AnxB11 - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - CG7339 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - CG9775 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - DnaJ-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - Nurf-38 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - Rab5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - RpS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - RpS15Ab anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - SmD2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - Srp54 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - TFAM anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - U4-U6-60K anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - alrm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - mRpL22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - mRpL51 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - mod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) AnxB11 - qkr58E-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions AnxB11 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58952 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030749 DroID - A comprehensive database of gene and protein interactions. • FBgn0030749 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32612
Orthologs
OrthoDB Orthologs (132) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6WDDXT Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6FN3DT Arthropod inclusive ortholog search EOG61894D Metazoa inclusive ortholog search EOG6HXHV6
Orthologs in Drosophila Species (EOG6WDDXT)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\AnxB11     Drosophila simulans   Dsim\GD15750 Y   Drosophila sechellia   Dsec\GM13401 Y   Drosophila erecta   Dere\GG19323 Y   Drosophila yakuba   Dyak\GE15970 Y   Drosophila ananassae   Dana\GF19282 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22156 Y   Drosophila persimilis   Dper\GL15887 Y   Drosophila willistoni   Dwil\GK25708 Y   Drosophila virilis   Dvir\GJ19360 Y   Drosophila mojavensis   Dmoj\GI14303 Y   Drosophila grimshawi   Dgri\GH12030 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6FN3DT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC409068   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007888   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16531   Atta cephalotes Leafcutter ant  Acep\ACEP26372   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16325   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17905   Linepithema humile Argentine ant  Lhum\LH20935   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13641   Solenopsis invicta Red fire ant  Sinv\SINV10431   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002346   Acyrthosiphon pisum Pea aphid  Apim\ACYPI42257   Bombyx mori Silkmoth  Bmor\BGIBMGA002773   Pediculus humanus Human body louse  Phum\PHUM623880   Pediculus humanus Human body louse  Phum\PHUM014750   Tribolium castaneum Red flour beetle  Tcas\TC011792   Tribolium castaneum Red flour beetle  Tcas\TC011793   Tribolium castaneum Red flour beetle  Tcas\TC011791
Orthologs in non-Insect Arthropods (EOG61894D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_324371 Y Daphnia pulex Water flea  Dpux\JGI_V11_68257 Y Daphnia pulex Water flea  Dpux\rps4 Y Daphnia pulex Water flea  Dpux\JGI_V11_226743 Y Daphnia pulex Water flea  Dpux\apoa4 Y Daphnia pulex Water flea  Dpux\JGI_V11_305807 Y Daphnia pulex Water flea  Dpux\JGI_V11_305145 Y Daphnia pulex Water flea  Dpux\PPRC1 Y Daphnia pulex Water flea  Dpux\JGI_V11_215008 Y Daphnia pulex Water flea  Dpux\atpB Y Daphnia pulex Water flea  Dpux\JGI_V11_231205 Y Daphnia pulex Water flea  Dpux\JGI_V11_199988 Y Daphnia pulex Water flea  Dpux\JGI_V11_302630 Y Daphnia pulex Water flea  Dpux\petN Y Ixodes scapularis Deer tick  Isca\ISCW022221 Y Ixodes scapularis Deer tick  Isca\ISCW012245 Y
Orthologs in non-Arthropod Metazoa (EOG6HXHV6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\nex-2 Y Caenorhabditis elegans Nematode  Cele\nex-1 Y Caenorhabditis elegans Nematode  Cele\nex-3 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019139gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000475gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025962gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011106gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011107gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024188gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006003gn Y Danio rerio Zebrafish  Drer\anxa6 Y Danio rerio Zebrafish  Drer\CH211-191A6.4 Y Danio rerio Zebrafish  Drer\anxa1c Y Danio rerio Zebrafish  Drer\anxa11b Y Danio rerio Zebrafish  Drer\ENSDARG00000053593 Y Danio rerio Zebrafish  Drer\anxa13 Y Danio rerio Zebrafish  Drer\anxa1a Y Danio rerio Zebrafish  Drer\anxa1b Y Danio rerio Zebrafish  Drer\CH211-252F13.1 Y Danio rerio Zebrafish  Drer\anxa11a Y Danio rerio Zebrafish  Drer\anxa2a Y Danio rerio Zebrafish  Drer\anxa4 Y Danio rerio Zebrafish  Drer\anxa3b Y Danio rerio Zebrafish  Drer\anxa2b Y Danio rerio Zebrafish  Drer\anxa5a Y Danio rerio Zebrafish  Drer\anxa5b Y Danio rerio Zebrafish  Drer\ENSDARG00000043936 Y Xenopus tropicalis Western clawed frog  Xtro\anxa6 Y Xenopus tropicalis Western clawed frog  Xtro\anxa2 Y Xenopus tropicalis Western clawed frog  Xtro\anxa7 Y Xenopus tropicalis Western clawed frog  Xtro\anxa5 Y Xenopus tropicalis Western clawed frog  Xtro\anxa11 Y Xenopus tropicalis Western clawed frog  Xtro\anxa3 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031026 Y Xenopus tropicalis Western clawed frog  Xtro\anxa8 Y Xenopus tropicalis Western clawed frog  Xtro\anxa10 Y Xenopus tropicalis Western clawed frog  Xtro\anxa1 Y Xenopus tropicalis Western clawed frog  Xtro\anxa13 Y Xenopus tropicalis Western clawed frog  Xtro\anxa4 Y Gallus gallus Domestic chicken  Ggal\ANXA2 Y Gallus gallus Domestic chicken  Ggal\ANXA1 Y Gallus gallus Domestic chicken  Ggal\ANXA5 Y Gallus gallus Domestic chicken  Ggal\ANXA7 Y Gallus gallus Domestic chicken  Ggal\ANXA10 Y Gallus gallus Domestic chicken  Ggal\ANXA8 Y Gallus gallus Domestic chicken  Ggal\ANXA6 Y Gallus gallus Domestic chicken  Ggal\ANXA11 Y Gallus gallus Domestic chicken  Ggal\ANXA13 Y Mus musculus House mouse  Mmus\Anxa1 Y Mus musculus House mouse  Mmus\Anxa7 Y Mus musculus House mouse  Mmus\Anxa8 Y Mus musculus House mouse  Mmus\Anxa11 Y Mus musculus House mouse  Mmus\Anxa3 Y Mus musculus House mouse  Mmus\Anxa9 Y Mus musculus House mouse  Mmus\Anxa6 Y Mus musculus House mouse  Mmus\Anxa5 Y Mus musculus House mouse  Mmus\Anxa2 Y Mus musculus House mouse  Mmus\Anxa13 Y Mus musculus House mouse  Mmus\Anxa4 Y Mus musculus House mouse  Mmus\Anxa10 Y Rattus norvegicus Norway rat  Rnor\Anxa6 Y Rattus norvegicus Norway rat  Rnor\Anxa9 Y Rattus norvegicus Norway rat  Rnor\Anxa10 Y Rattus norvegicus Norway rat  Rnor\Anxa7 Y Rattus norvegicus Norway rat  Rnor\Anxa13 Y Rattus norvegicus Norway rat  Rnor\Anxa4 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000025698 Y Rattus norvegicus Norway rat  Rnor\Anxa5 Y Rattus norvegicus Norway rat  Rnor\Anxa8 Y Rattus norvegicus Norway rat  Rnor\Anxa1 Y Rattus norvegicus Norway rat  Rnor\Anxa2 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000025176 Y Rattus norvegicus Norway rat  Rnor\Anxa11 Y Homo sapiens Human  Hsap\ANXA9 Y Homo sapiens Human  Hsap\ANXA6 Y Homo sapiens Human  Hsap\ENSG00000138279 Y Homo sapiens Human  Hsap\ANXA1 Y Homo sapiens Human  Hsap\ANXA10 Y Homo sapiens Human  Hsap\ANXA11 Y Homo sapiens Human  Hsap\ANXA5 Y Homo sapiens Human  Hsap\ANXA4 Y Homo sapiens Human  Hsap\ENSG00000186807 Y Homo sapiens Human  Hsap\ANXA2 Y Homo sapiens Human  Hsap\ANXA3 Y Homo sapiens Human  Hsap\ANXA8L1 Y Homo sapiens Human  Hsap\ANXA8 Y Homo sapiens Human  Hsap\ENSG00000104537 Y
Human Orthologs (14)
Gene OMIM HGNC Hsap\ANXA9     Hsap\ANXA6     Hsap\ENSG00000138279     Hsap\ANXA1     Hsap\ANXA10     Hsap\ANXA11     Hsap\ANXA5     Hsap\ANXA4     Hsap\ENSG00000186807     Hsap\ANXA2     Hsap\ANXA3     Hsap\ANXA8L1     Hsap\ANXA8     Hsap\ENSG00000104537
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15750 Drosophila sechellia Dsec\GM13401 Drosophila erecta Dere\GG19323 Drosophila yakuba Dyak\GE15970 Drosophila ananassae Dana\GF19282 Drosophila pseudoobscura pseudoobscura Dpse\GA22156 Drosophila persimilis Dper\GL15887 Drosophila willistoni Dwil\GK25708 Drosophila virilis Dvir\GJ19360 Drosophila mojavensis Dmoj\GI14303 Drosophila grimshawi Dgri\GH12030
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	34420 y1 w* Mi{MIC}AnxB11MI01310 38311 y1 sc* v1; P{TRiP.HMS01775}attP40
VDRC	v101313 P{KK107526}VIE-260B v29693 w1118; P{GD15109}v29693 v36185 w1118; P{GD14328}v36185 v36186 w1118; P{GD14328}v36186
Genomic Clones ( 2 )
	BACR13G13 BACR47D09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 72 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH16395 GM13766
Other clones	DPiM_GM13766 LD19596
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05676 GH26271 LD16837 RE03488 RE06101 RE15943 RE16062 RE17116 RE20671 RE28852 RE29846 RE30369 RE30682 RE34869 RE39231 RE40966 RE42476 RE52631 RE54515 RE59460 RE60279 RE60412 RE67203 RE68475 RE70487 RH59331 RH72116
Other clones	357 7818 44009 61215 102907 104287 120403 120567 214219.28 274653 bs79b04 CK01.70D.B12 CK01.119B.E1 EK056240 EK057202 EK091017 EK105347 EK105926 EK160235 EK165333 EK173543 EK176950 EK181402 EK184754 EK224751 EK240315 EK249109 EK302462 EP04644 EP08907 EP14161 EP16837 ESG012c.E21_F03 ESG015b.E21_H09 ESG0111b.B21.1_E04 ESG0112c.B21.1_D10 FGM103H12 FGM214B03 FGM306H11 RP003054069 UUGC0148
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030749 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32612
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: AnxB11 Anxb11 (FlyBase, 2009-) Source for identity of: Anxb11 CG9968 (FlyBase, 1996-)
Source for database merge of	Source for merge of: Anxb11 BcDNA:GH16395 (FlyBase, 1996-)
Additional comments	FlyBase curator comment: Renamed from 'Anxb11' to 'AnxB11' in order to make the nomenclature of D. melanogaster Annexins consistent with each other and with the standard Annexin nomenclature. (FlyBase, 2009-) Source for merge of Anxb11 BcDNA:GH16395 was TrEMBL update (date:020807). (FlyBase, 1996-) Source for identity of Anxb11 CG9968 was sequence comparison (date:000407). (FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078646 NM_167519 NM_001272685 NM_001272686 NM_001272687 NM_001272688 NM_001272689 RefSeq (Proteins) • NP_523370 NP_727978 NP_001259614 NP_001259615 NP_001259616 NP_001259617 NP_001259618 DDBJ / EMBL / GenBank • AA803645 AAF48609 AAF48610 AAL13626 AAM52650 AGB95456 AGB95457 AGB95458 AGB95459 AGB95460 AI293253 AJ276963 AW940623 AY058397 AY122138 CAB86189 Entrez Gene - A searchable database of RefSeq genes. • 32612 UniProtKB/Swiss-Prot • Q9VXG4 UniProtKB/TrEMBL • Q9VXG3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Annexin (IPR001464) Annexin repeat, conserved site (IPR018252) Annexin repeat (IPR018502) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM13766
Linkouts
	BioGRID - A database of protein and genetic interactions • 58952 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030749 DroID - A comprehensive database of gene and protein interactions. • FBgn0030749 DRSC - Results from RNAi screens. • FBgn0030749 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030749 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9968-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030749 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32612 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32612 modMine - Data generated by the modENCODE project. • FBgn0030749
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	annexin (Löw et al., 2007) Anxb11 (Schnorrer et al., 2010, Curtis et al., 2007, Japanese National Institute of Genetics, 2012.5.21, Stuart et al., 2007, Kim et al., 2005) AnxB11 (Stoltzfus and Grotewiel, 2003, Tjota et al., 2011, ) ANXB11 (Iglesias et al., 2002) BcDNA:GH16395   CG9968 (Goldstein and Gunawardena, 2000, Keleman et al., 2009.8.5, Cammarato et al., 2011, Ni et al., 2010.12.1)
Name Synonym	Annexin B11 (Fernandez, 2000.3.29, Cammarato et al., 2011) annexin B11 (Jovceva et al., 2007)
Secondary FlyBase IDs
	FBgn0046794
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 1 ) FlyBase analysis  ( 5 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Tjota et al., 2011, J. Cell Sci. 124(17): 2914--2926 Annexin B9 binds to {beta}H-spectrin and is required for multivesicular body function in Drosophila. [FBrf0215049] Show all research papers ...