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Gene Dmel\rngo

General Information
Symbol	Dmel\rngo	Species	D. melanogaster
Name	rings lost	Annotation symbol	CG4420
Feature type	protein_coding_gene	FlyBase ID	FBgn0030753
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	14C6-14C6	Sequence location	X:16,335,466..16,339,400 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene rings lost is referred to in FlyBase by the symbol Dmel\rngo (CG4420, FBgn0030753). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: ubiquitin binding; proteasome binding. There is experimental evidence that it is involved in the biological process: female germline ring canal formation. 13 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Aspartic peptidase; Aspartic peptidase, DDI1-type; Peptidase A2A, retrovirus, catalytic; UBA-like; Ubiquitin; Ubiquitin supergroup; Ubiquitin-associated/translation elongation factor EF1B, N-terminal; Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules, larval fat body, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637470_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG4420. Gene sequence location is X:16335466..16339400.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 14C6-14C6   Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\rngo for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) rngo-RA FBtr0074278  NM_132901   2336   458
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein rngo-PA   FBpp0074054   50.5   458   4.78     NP_573129   AAF48614
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-associated/translation elongation factor EF1B, N-terminal (IPR000449) Ubiquitin (IPR000626) Peptidase A2A, retrovirus, catalytic (IPR001995) UBA-like (IPR009060) Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (IPR015940) Ubiquitin supergroup (IPR019955) Aspartic peptidase (IPR021109) Aspartic peptidase, DDI1-type (IPR019103)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695891   AA697208   AA802219   AE014298 AAF48614   AI260024   AI405527   AJ570497   AJ570498   AJ570499   AJ570500   AJ570501   AJ570503   AJ570504   AJ570505   AJ570506   AJ570507   AJ570508   AJ570509   AJ570510   AJ570511   AJ570512   AJ570514   AJ570515   AJ570516   AJ570517   AJ570518   AJ570519   AJ570520   AJ570521   AJ570522   AW941205   AY075184 AAL68054   BF486670   BF496824   BF496879   BF498657   BI228244   BI239301   BI375498   BI571691   BI574215   BI578455   BI587289   BI606619   BI612768   BP547552   BQ103606   BQ103745   BT006019 AAO74702   CO155205   CO155745   CO177791   CO177869   CO266262   CO286546   CO298977   CO305824   CO331810   CZ478046   CZ482341   CZ482342   EC051484   EC051957   EC053216   EC054208   EC054212   EC054221   EC054968   EC056358   EC056576   EC079191   EC203127   EC210505   EC226351   EC262898   EC267526   GH748067   GH748080   GH748119   GH748303   GH748513   GH748658   GH748689   GH748952   GH748971   GH749301   GH750349   GH751177   GH751187   GH751439   GH751521   GH751636   GH751910   GH752856   GH753030   GH753127   GH753302   GH754160   GH754162   GH754427   GH755331   GH755606   GH755735   GH757226   GH757415   GH757482   GH757524   GH758133   GH758424   GH758593   GH758915   GH759400   GH759603   GH760821   GH761085   GH761144   GH770141   GH770601   GH770780   GH770982   GH771133   GH771223   GH772577   GH773263   GH773647   GH773829   GH774025   GH774203   GH774856   GH775021   GH775392   GH775409   GH775612   GH778153   GH778278   GH778754   GH780582   GH781456   GH783372   GH783534   GH783999   GH784221   GH784261   GH784374   GH784539   GH784660   GH784732   GH785161   GH785382   GH785698   GH786090   GH786179   GH786348   GH786608   GH786711   GH787220   GH787354   GH787455   GH787907   GH788210   GH788467   GH788737   GH789174   GH789193   GH789274   GH790066   GH790244   GH790396   GH790859   GH790922   GH791028   GH791205   GH791295   GH791372   GH791415   GH792557   GH792697   GH792729   GH792801   GH792851   GH792873   GH794043   GH794208   GH795370   GH795756   GH795812   GH796839   GH797006   GH797070   GH797341   GH797527   GH798262   GH798414   GH799976   GH800303   GH800649   GH800753   GH801020   GH801867   GH802516   GH802634   GH803111   GH803350   GH803890   GH804300   GH805349   GH805410   GH805589   GH805857   GH806165   GH806515   GH806516   GH806730   GH806755   GH806796   GH806807   GH807076   GH807093   GH807145   GH807257   GH807712   GH807745   GH808004   GH808083   GH808120   GH808130   GH808188   GH808192   GH808198   GH808277   GH809410   GH809676   GH809810   GH809859   GH810234   GH811241   GH811561   GH811631   GH811641   GH811951   GH812302   GH812618   GH813156   GH813328   GH813757   GH814437   GH815352   GH815499   GH816009   GH816450   GH816505   GH816508   GH816729   GH816963   GH817115   GH817455   GH817523   GH818125   GH818213   GH818648   GH819063   GH819269   GH820395   GH820431   GH820458   GH820777   GH820873   GH821397   GH821448   GH821560   GH824147   GH824383   GH824532   GH826504   GH826590   GH827299   GH827866   GH828638   GH828977   GH830245   GH830617   GH830704   GH830960   GH831026   GH831314   GH831549   GH832000   GH832175   GH832212   GH832256   GH832347   GH832694   GH833453   GH833753   GH835090   GH835298   GH835389   GH835609   GH836641   GH836729   GH838962   GH839092   GH839988   GH840154   GH840219   GH841157   GH841343   GH841592   GH842520   GH842864   GH843264   GH843309   GH843996   GH844524   GH844545   GH844573   GH844680   GH845012   GH845093   GH845181   GH845328   GH845685   GH846235   GH846339   GH847223   GH847467   GH848312   GH849452   GH850032   GH850038   GH850084   GH850247   GH851026   GH851472   GH851798   GH852077   GH852384   GH852396   GH852596   GH852735   GH853926   GH854621   GH854858   GH855447   GH856038   GH856092   GH856718   GH857818   GH858151   GH858176   GH858528   GH859062   GH860386   GH860752   GH862251   GH862517   GH863017   GH863096   GH863382   GH863830   GH864180   GH864216   GH865069   GH865324   GH865869   GH866122   GH866315   GH866632   GH867032   GH867131   GH868997   GH870582   GH872814   GH873203   GH873306   GH874289   GH875508   GH875965   GH876223   GH876544   GH877654   GH877786   GH878276   GH878408   GH878431   GH878433   GH878478   GH878818   GH878824   GH879138   GH879214   GH879256   GH879277   GH879515   GH879702   GH879814   GH880059   GH880673   GH881646   GH881749   GH882287   GH882334   GH883291   GH884123   GH884154   GH884412   GH884516   GH884549   GH885283   GH885390   GH886753   GH887048   GH888602   GH888698   GH889185   GH889385   GH889433   GH891918   GH891938   GH892363   GH892532   GH892611   GH896028   GH896170   GH896459   GH896938   GH897172   GH898011   GH898254   GH898398   GH898784   GH898924   GH899257   GH899704   GH899960   GH900206   GH900547   GH900688   GH900748   GH900965   GH901211   GH901228   GH903103   GH903917   GH904006   GH904008   GH904072   GH904601   GH904730   GH904736   GH906220   GH906787   GH906894   GH906923   GH907413   GH907735   GH908296   GH909377   GH909930   GH910109   GH910154   GH910288   GH911063   GH911086   GH911608   GH911650   GH911807   GH912638   GH912826   GH912931   GH913110   GH913994   GH914040   GH914239   GH914520   GH914929   GH915156   GH915180   GH915507   GH915535   GH916426   GH916501   GH917056   GH917446   GH917693   GH917708   GH918572   GH920641   GH920642   GH920714   GH921205   GH921578   GH921777   GH922250   GH922362   GH922817   GH923042   GH923242   GH923281   GH923765   GH924914   GH925056   GH925251   GH925340   GH925515   GH925768   GH926154   GH926265   GH926841   GH927283   GH927349   GH927840   GH928064   GH928148   GH928485   GH928776   GH929242   GH929551   GH929662   GH930024   GH930507   GH931104   GH931565   GH932047   GH932252   GH932345   GH933018   GH933063   GH933389   GH933531   GH933800   GH933838   GH934114   GH934245   GH934625   GH934859   GH935201   GH935691   GH936718   GH936902   GH937204   GH937351   GH937430   GH937830   GH937906   GH937919   GH938340   GH939006
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VXF9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium anterior endoderm   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic neuroblast of ventral nerve cord primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Morawe et al., 2011) nucleus inferred from direct assay (Morawe et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules, larval fat body, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    289.175 Larval Midgut    439.3 Larval Hindgut    470.3 Larval Malpighian Tubules    558.2 Larval Fat Body    560.5 Larval Salivary Gland    321 Larval Trachea    288.15 Larval Carcass    952.75 Adult Head    174 Adult Eye    109 Adult Brain    114 Adult Thoracic-Abdominal Ganglion    104 Adult Crop    293.7 Adult Midgut    222.8 Adult Hindgut    181.6 Adult Malpighian Tubules    125.8 Adult Fat Body    432.1 Adult Salivary Gland    95.2 Adult Heart    432.55 Adult VirginFemale Spermatheca    213.4 Adult InseminatedFemale Spermatheca    184.2 Adult Ovary    413.6 Adult Testis    426.2 Adult Male Accessory Gland    199.3 Adult Carcass    294.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    289.175 Larval Midgut    439.3 Larval Hindgut    470.3 Larval Malpighian Tubules  (558.2) Larval Fat Body  (560.5) Larval Salivary Gland    321 Larval Trachea    288.15 Larval Carcass  (952.75) Adult Head    174 Adult Eye    109 Adult Brain    114 Adult Thoracic-Abdominal Ganglion    104 Adult Crop    293.7 Adult Midgut    222.8 Adult Hindgut    181.6 Adult Malpighian Tubules    125.8 Adult Fat Body    432.1 Adult Salivary Gland    95.2 Adult Heart    432.55 Adult VirginFemale Spermatheca    213.4 Adult InseminatedFemale Spermatheca    184.2 Adult Ovary    413.6 Adult Testis    426.2 Adult Male Accessory Gland    199.3 Adult Carcass    294.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    289.175 Larval Midgut    439.3 Larval Hindgut    470.3 Larval Malpighian Tubules    558.2 Larval Fat Body    560.5 Larval Salivary Gland    321 Larval Trachea    288.15 Larval Carcass    952.75 Adult Head    174 Adult Eye    109 Adult Brain    114 Adult Thoracic-Abdominal Ganglion    104 Adult Crop    293.7 Adult Midgut    222.8 Adult Hindgut    181.6 Adult Malpighian Tubules    125.8 Adult Fat Body    432.1 Adult Salivary Gland    95.2 Adult Heart    432.55 Adult VirginFemale Spermatheca    213.4 Adult InseminatedFemale Spermatheca    184.2 Adult Ovary    413.6 Adult Testis    426.2 Adult Male Accessory Gland    199.3 Adult Carcass    294.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    289.175 Larval Midgut    439.3 Larval Hindgut    470.3 Larval Malpighian Tubules    558.2 Larval Fat Body    560.5 Larval Salivary Gland    321 Larval Trachea    288.15 Larval Carcass    952.75 Adult Head    174 Adult Eye    109 Adult Brain    114 Adult Thoracic-Abdominal Ganglion    104 Adult Crop    293.7 Adult Midgut    222.8 Adult Hindgut    181.6 Adult Malpighian Tubules    125.8 Adult Fat Body    432.1 Adult Salivary Gland    95.2 Adult Heart    432.55 Adult VirginFemale Spermatheca    213.4 Adult InseminatedFemale Spermatheca    184.2 Adult Ovary    413.6 Adult Testis    426.2 Adult Male Accessory Gland    199.3 Adult Carcass    294.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    289.175 Larval Midgut    439.3 Larval Hindgut    470.3 Larval Malpighian Tubules    558.2 Larval Fat Body    560.5 Larval Salivary Gland    321 Larval Trachea    288.15 Larval Carcass    952.75 Adult Head    174 Adult Eye    109 Adult Brain    114 Adult Thoracic-Abdominal Ganglion    104 Adult Crop    293.7 Adult Midgut    222.8 Adult Hindgut    181.6 Adult Malpighian Tubules    125.8 Adult Fat Body    432.1 Adult Salivary Gland    95.2 Adult Heart    432.55 Adult VirginFemale Spermatheca    213.4 Adult InseminatedFemale Spermatheca    184.2 Adult Ovary    413.6 Adult Testis    426.2 Adult Male Accessory Gland    199.3 Adult Carcass    294.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    289.175 Larval Midgut    439.3 Larval Hindgut    470.3 Larval Malpighian Tubules  558.2 Larval Fat Body  560.5 Larval Salivary Gland    321 Larval Trachea    288.15 Larval Carcass  (952.75) Adult Head    174 Adult Eye    109 Adult Brain    114 Adult Thoracic-Abdominal Ganglion    104 Adult Crop    293.7 Adult Midgut    222.8 Adult Hindgut    181.6 Adult Malpighian Tubules    125.8 Adult Fat Body    432.1 Adult Salivary Gland    95.2 Adult Heart    432.55 Adult VirginFemale Spermatheca    213.4 Adult InseminatedFemale Spermatheca    184.2 Adult Ovary    413.6 Adult Testis    426.2 Adult Male Accessory Gland    199.3 Adult Carcass    294.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    289.175 Larval Midgut    439.3 Larval Hindgut    470.3 Larval Malpighian Tubules    558.2 Larval Fat Body    560.5 Larval Salivary Gland    321 Larval Trachea    288.15 Larval Carcass    952.75 Adult Head    174 Adult Eye    109 Adult Brain    114 Adult Thoracic-Abdominal Ganglion    104 Adult Crop    293.7 Adult Midgut    222.8 Adult Hindgut    181.6 Adult Malpighian Tubules    125.8 Adult Fat Body    432.1 Adult Salivary Gland    95.2 Adult Heart    432.55 Adult VirginFemale Spermatheca    213.4 Adult InseminatedFemale Spermatheca    184.2 Adult Ovary    413.6 Adult Testis    426.2 Adult Male Accessory Gland    199.3 Adult Carcass    294.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    289.175 Larval Midgut    439.3 Larval Hindgut    470.3 Larval Malpighian Tubules    558.2 Larval Fat Body    560.5 Larval Salivary Gland    321 Larval Trachea    288.15 Larval Carcass    952.75 Adult Head    174 Adult Eye    109 Adult Brain    114 Adult Thoracic-Abdominal Ganglion    104 Adult Crop    293.7 Adult Midgut    222.8 Adult Hindgut    181.6 Adult Malpighian Tubules    125.8 Adult Fat Body    432.1 Adult Salivary Gland    95.2 Adult Heart    432.55 Adult VirginFemale Spermatheca    213.4 Adult InseminatedFemale Spermatheca    184.2 Adult Ovary    413.6 Adult Testis    426.2 Adult Male Accessory Gland    199.3 Adult Carcass    294.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    174   NA  Eye    109   NA  Brain    114   289.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    104   NA  Crop    293.7   439.3  Midgut    222.8   470.3  Hindgut    181.6   558.2  Malpighian Tubules    125.8   560.5  Fat Body    432.1   321  Salivary Gland    95.2   NA  Heart    432.55   288.15  Trachea    NA   NA  VirginFemale Spermatheca    213.4   NA  InseminatedFemale Spermatheca    184.2   NA  Ovary    413.6   NA  Testis    426.2   NA  Male Accessory Gland    199.3   952.75  Carcass    294.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    63 central nervous system, pupae P8    26 head, virgin 1-day female    15 head, virgin 4-day female    25 head, virgin 20-day female    23 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    26 head, mated 1-day male    24 head, mated 4-day male    30 head, mated 20-day male    37 salivary gland, larvae L3 wandering    27 salivary gland, white prepupae    92 digestive system, larvae L3 wandering    90 digestive system, 1-day adult    30 digestive system, 4-day adult    34 digestive system, 20-day adult    32 fat body, larvae L3 wandering    58 fat body, white prepupae    43 fat body, pupae P8    47 carcass, larvae L3 wandering    172 carcass, 1-day adult    38 carcass, 4-day adult    47 carcass, 20-day adult    56 ovary, virgin 4-day female    116 ovary, mated 4-day female    134 testis, mated 4-day male    80 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (85) central nervous system, larvae L3  (63) central nervous system, pupae P8  26 head, virgin 1-day female    15 head, virgin 4-day female    25 head, virgin 20-day female    23 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female  26 head, mated 1-day male    24 head, mated 4-day male  (30) head, mated 20-day male  (37) salivary gland, larvae L3 wandering  (27) salivary gland, white prepupae  (92) digestive system, larvae L3 wandering  (90) digestive system, 1-day adult  (30) digestive system, 4-day adult  (34) digestive system, 20-day adult  (32) fat body, larvae L3 wandering  (58) fat body, white prepupae  (43) fat body, pupae P8  (47) carcass, larvae L3 wandering  (172) carcass, 1-day adult  (38) carcass, 4-day adult  (47) carcass, 20-day adult  (56) ovary, virgin 4-day female  (116) ovary, mated 4-day female  (134) testis, mated 4-day male  (80) accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    63 central nervous system, pupae P8    26 head, virgin 1-day female    15 head, virgin 4-day female    25 head, virgin 20-day female    23 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    26 head, mated 1-day male    24 head, mated 4-day male    30 head, mated 20-day male    37 salivary gland, larvae L3 wandering    27 salivary gland, white prepupae    92 digestive system, larvae L3 wandering    90 digestive system, 1-day adult    30 digestive system, 4-day adult    34 digestive system, 20-day adult    32 fat body, larvae L3 wandering    58 fat body, white prepupae    43 fat body, pupae P8    47 carcass, larvae L3 wandering  (172) carcass, 1-day adult    38 carcass, 4-day adult    47 carcass, 20-day adult    56 ovary, virgin 4-day female  (116) ovary, mated 4-day female  (134) testis, mated 4-day male    80 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    63 central nervous system, pupae P8    26 head, virgin 1-day female    15 head, virgin 4-day female    25 head, virgin 20-day female    23 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    26 head, mated 1-day male    24 head, mated 4-day male    30 head, mated 20-day male    37 salivary gland, larvae L3 wandering    27 salivary gland, white prepupae    92 digestive system, larvae L3 wandering    90 digestive system, 1-day adult    30 digestive system, 4-day adult    34 digestive system, 20-day adult    32 fat body, larvae L3 wandering    58 fat body, white prepupae    43 fat body, pupae P8    47 carcass, larvae L3 wandering    172 carcass, 1-day adult    38 carcass, 4-day adult    47 carcass, 20-day adult    56 ovary, virgin 4-day female    116 ovary, mated 4-day female    134 testis, mated 4-day male    80 accessory gland, mated 4-day male    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    63 central nervous system, pupae P8    26 head, virgin 1-day female    15 head, virgin 4-day female    25 head, virgin 20-day female    23 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    26 head, mated 1-day male    24 head, mated 4-day male    30 head, mated 20-day male    37 salivary gland, larvae L3 wandering    27 salivary gland, white prepupae    92 digestive system, larvae L3 wandering    90 digestive system, 1-day adult    30 digestive system, 4-day adult    34 digestive system, 20-day adult    32 fat body, larvae L3 wandering    58 fat body, white prepupae    43 fat body, pupae P8    47 carcass, larvae L3 wandering    172 carcass, 1-day adult    38 carcass, 4-day adult    47 carcass, 20-day adult    56 ovary, virgin 4-day female    116 ovary, mated 4-day female    134 testis, mated 4-day male    80 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (85) central nervous system, larvae L3  (63) central nervous system, pupae P8  26 head, virgin 1-day female    15 head, virgin 4-day female    25 head, virgin 20-day female    23 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female  26 head, mated 1-day male    24 head, mated 4-day male  30 head, mated 20-day male  (37) salivary gland, larvae L3 wandering  27 salivary gland, white prepupae  (92) digestive system, larvae L3 wandering  (90) digestive system, 1-day adult  30 digestive system, 4-day adult  (34) digestive system, 20-day adult  32 fat body, larvae L3 wandering  (58) fat body, white prepupae  (43) fat body, pupae P8  (47) carcass, larvae L3 wandering  (172) carcass, 1-day adult  (38) carcass, 4-day adult  (47) carcass, 20-day adult  (56) ovary, virgin 4-day female  (116) ovary, mated 4-day female  (134) testis, mated 4-day male  (80) accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    63 central nervous system, pupae P8    26 head, virgin 1-day female    15 head, virgin 4-day female    25 head, virgin 20-day female    23 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    26 head, mated 1-day male    24 head, mated 4-day male    30 head, mated 20-day male    37 salivary gland, larvae L3 wandering    27 salivary gland, white prepupae    92 digestive system, larvae L3 wandering    90 digestive system, 1-day adult    30 digestive system, 4-day adult    34 digestive system, 20-day adult    32 fat body, larvae L3 wandering    58 fat body, white prepupae    43 fat body, pupae P8    47 carcass, larvae L3 wandering  (172) carcass, 1-day adult    38 carcass, 4-day adult    47 carcass, 20-day adult    56 ovary, virgin 4-day female  116 ovary, mated 4-day female  134 testis, mated 4-day male    80 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    63 central nervous system, pupae P8    26 head, virgin 1-day female    15 head, virgin 4-day female    25 head, virgin 20-day female    23 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    26 head, mated 1-day male    24 head, mated 4-day male    30 head, mated 20-day male    37 salivary gland, larvae L3 wandering    27 salivary gland, white prepupae    92 digestive system, larvae L3 wandering    90 digestive system, 1-day adult    30 digestive system, 4-day adult    34 digestive system, 20-day adult    32 fat body, larvae L3 wandering    58 fat body, white prepupae    43 fat body, pupae P8    47 carcass, larvae L3 wandering    172 carcass, 1-day adult    38 carcass, 4-day adult    47 carcass, 20-day adult    56 ovary, virgin 4-day female    116 ovary, mated 4-day female    134 testis, mated 4-day male    80 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    35 embryo 04-06hr    48 embryo 06-08hr    55 embryo 08-10hr    44 embryo 10-12hr    32 embryo 12-14hr    21 embryo 14-16hr    17 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    15 larva L2    17 larva L3 12hr old    18 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    94 white prepupae new    53 white prepupae 12hr    40 white prepupae 24hr    33 pupae 2d postWPP    27 pupae 3d postWPP    38 pupae 4d postWPP    27 adult male 01day    35 adult male 05day    47 adult male 30day    50 adult female 01day    42 adult female 05day    54 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (75) embryo 02-04hr  (35) embryo 04-06hr  (48) embryo 06-08hr  (55) embryo 08-10hr  (44) embryo 10-12hr  (32) embryo 12-14hr    21 embryo 14-16hr    17 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    15 larva L2    17 larva L3 12hr old    18 larva L3 puffstage 1-2  (50) larva L3 puffstage 3-6  (94) larva L3 puffstage 7-9  (94) white prepupae new  (53) white prepupae 12hr  (40) white prepupae 24hr  (33) pupae 2d postWPP  (27) pupae 3d postWPP  (38) pupae 4d postWPP  (27) adult male 01day  (35) adult male 05day  (47) adult male 30day  (50) adult female 01day  (42) adult female 05day  (54) adult female 30day  (57) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    35 embryo 04-06hr    48 embryo 06-08hr    55 embryo 08-10hr    44 embryo 10-12hr    32 embryo 12-14hr    21 embryo 14-16hr    17 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    15 larva L2    17 larva L3 12hr old    18 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    94 white prepupae new    53 white prepupae 12hr    40 white prepupae 24hr    33 pupae 2d postWPP    27 pupae 3d postWPP    38 pupae 4d postWPP    27 adult male 01day    35 adult male 05day    47 adult male 30day    50 adult female 01day    42 adult female 05day    54 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    35 embryo 04-06hr    48 embryo 06-08hr    55 embryo 08-10hr    44 embryo 10-12hr    32 embryo 12-14hr    21 embryo 14-16hr    17 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    15 larva L2    17 larva L3 12hr old    18 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    94 white prepupae new    53 white prepupae 12hr    40 white prepupae 24hr    33 pupae 2d postWPP    27 pupae 3d postWPP    38 pupae 4d postWPP    27 adult male 01day    35 adult male 05day    47 adult male 30day    50 adult female 01day    42 adult female 05day    54 adult female 30day    57 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    35 embryo 04-06hr    48 embryo 06-08hr    55 embryo 08-10hr    44 embryo 10-12hr    32 embryo 12-14hr    21 embryo 14-16hr    17 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    15 larva L2    17 larva L3 12hr old    18 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    94 white prepupae new    53 white prepupae 12hr    40 white prepupae 24hr    33 pupae 2d postWPP    27 pupae 3d postWPP    38 pupae 4d postWPP    27 adult male 01day    35 adult male 05day    47 adult male 30day    50 adult female 01day    42 adult female 05day    54 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (75) embryo 02-04hr  (35) embryo 04-06hr  (48) embryo 06-08hr  (55) embryo 08-10hr  (44) embryo 10-12hr  32 embryo 12-14hr    21 embryo 14-16hr    17 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    15 larva L2    17 larva L3 12hr old    18 larva L3 puffstage 1-2  (50) larva L3 puffstage 3-6  (94) larva L3 puffstage 7-9  (94) white prepupae new  (53) white prepupae 12hr  (40) white prepupae 24hr  (33) pupae 2d postWPP  27 pupae 3d postWPP  (38) pupae 4d postWPP  27 adult male 01day  (35) adult male 05day  (47) adult male 30day  (50) adult female 01day  (42) adult female 05day  (54) adult female 30day  (57) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    35 embryo 04-06hr    48 embryo 06-08hr    55 embryo 08-10hr    44 embryo 10-12hr    32 embryo 12-14hr    21 embryo 14-16hr    17 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    15 larva L2    17 larva L3 12hr old    18 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    94 white prepupae new    53 white prepupae 12hr    40 white prepupae 24hr    33 pupae 2d postWPP    27 pupae 3d postWPP    38 pupae 4d postWPP    27 adult male 01day    35 adult male 05day    47 adult male 30day    50 adult female 01day    42 adult female 05day    54 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    75 embryo 02-04hr    35 embryo 04-06hr    48 embryo 06-08hr    55 embryo 08-10hr    44 embryo 10-12hr    32 embryo 12-14hr    21 embryo 14-16hr    17 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    15 larva L2    17 larva L3 12hr old    18 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    94 larva L3 puffstage 7-9    94 white prepupae new    53 white prepupae 12hr    40 white prepupae 24hr    33 pupae 2d postWPP    27 pupae 3d postWPP    38 pupae 4d postWPP    27 adult male 01day    35 adult male 05day    47 adult male 30day    50 adult female 01day    42 adult female 05day    54 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    161 Schneider line 2 Sg4    55 embryonic 1182-4H    57 embryonic GM2    87 embryonic Kc167    95 embryonic S1    59 embryonic S3    41 leg disc CME L1    69 wing disc CME-W2    48 wing disc ML-DmD8    53 wing disc ML-DmD9    65 wing disc ML-DmD16-c3    71 wing disc ML-DmD21    62 wing disc ML-DmD32    64 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    56 CNS ML-DmBG1-c1    51 CNS ML-DmBG2-c2    53 tumorous blood cells mbn2    47 ovary fGS/OSS    67 ovary OSC    92 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (161) Schneider line 2 Sg4  (55) embryonic 1182-4H  (57) embryonic GM2  (87) embryonic Kc167  (95) embryonic S1  (59) embryonic S3  (41) leg disc CME L1  (69) wing disc CME-W2  (48) wing disc ML-DmD8  (53) wing disc ML-DmD9  (65) wing disc ML-DmD16-c3  (71) wing disc ML-DmD21  (62) wing disc ML-DmD32  (64) haltere disc ML-DmD17-c3  (40) eye-antennal disc ML-DmD11  (56) antennal disc ML-DmD20-c5  (41) mixed discs ML-DmD4-c1  (56) CNS ML-DmBG1-c1  (51) CNS ML-DmBG2-c2  (53) tumorous blood cells mbn2  (47) ovary fGS/OSS  (67) ovary OSC  (92) ovary OSS  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (161) Schneider line 2 Sg4    55 embryonic 1182-4H    57 embryonic GM2    87 embryonic Kc167    95 embryonic S1    59 embryonic S3    41 leg disc CME L1    69 wing disc CME-W2    48 wing disc ML-DmD8    53 wing disc ML-DmD9    65 wing disc ML-DmD16-c3    71 wing disc ML-DmD21    62 wing disc ML-DmD32    64 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    56 CNS ML-DmBG1-c1    51 CNS ML-DmBG2-c2    53 tumorous blood cells mbn2    47 ovary fGS/OSS    67 ovary OSC    92 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    161 Schneider line 2 Sg4    55 embryonic 1182-4H    57 embryonic GM2    87 embryonic Kc167    95 embryonic S1    59 embryonic S3    41 leg disc CME L1    69 wing disc CME-W2    48 wing disc ML-DmD8    53 wing disc ML-DmD9    65 wing disc ML-DmD16-c3    71 wing disc ML-DmD21    62 wing disc ML-DmD32    64 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    56 CNS ML-DmBG1-c1    51 CNS ML-DmBG2-c2    53 tumorous blood cells mbn2    47 ovary fGS/OSS    67 ovary OSC    92 ovary OSS    26 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    161 Schneider line 2 Sg4    55 embryonic 1182-4H    57 embryonic GM2    87 embryonic Kc167    95 embryonic S1    59 embryonic S3    41 leg disc CME L1    69 wing disc CME-W2    48 wing disc ML-DmD8    53 wing disc ML-DmD9    65 wing disc ML-DmD16-c3    71 wing disc ML-DmD21    62 wing disc ML-DmD32    64 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    56 CNS ML-DmBG1-c1    51 CNS ML-DmBG2-c2    53 tumorous blood cells mbn2    47 ovary fGS/OSS    67 ovary OSC    92 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (161) Schneider line 2 Sg4  (55) embryonic 1182-4H  (57) embryonic GM2  (87) embryonic Kc167  (95) embryonic S1  (59) embryonic S3  (41) leg disc CME L1  (69) wing disc CME-W2  (48) wing disc ML-DmD8  (53) wing disc ML-DmD9  (65) wing disc ML-DmD16-c3  (71) wing disc ML-DmD21  (62) wing disc ML-DmD32  (64) haltere disc ML-DmD17-c3  (40) eye-antennal disc ML-DmD11  (56) antennal disc ML-DmD20-c5  (41) mixed discs ML-DmD4-c1  (56) CNS ML-DmBG1-c1  (51) CNS ML-DmBG2-c2  (53) tumorous blood cells mbn2  (47) ovary fGS/OSS  (67) ovary OSC  (92) ovary OSS  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (161) Schneider line 2 Sg4    55 embryonic 1182-4H    57 embryonic GM2    87 embryonic Kc167    95 embryonic S1    59 embryonic S3    41 leg disc CME L1    69 wing disc CME-W2    48 wing disc ML-DmD8    53 wing disc ML-DmD9    65 wing disc ML-DmD16-c3    71 wing disc ML-DmD21    62 wing disc ML-DmD32    64 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    56 CNS ML-DmBG1-c1    51 CNS ML-DmBG2-c2    53 tumorous blood cells mbn2    47 ovary fGS/OSS    67 ovary OSC    92 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    161 Schneider line 2 Sg4    55 embryonic 1182-4H    57 embryonic GM2    87 embryonic Kc167    95 embryonic S1    59 embryonic S3    41 leg disc CME L1    69 wing disc CME-W2    48 wing disc ML-DmD8    53 wing disc ML-DmD9    65 wing disc ML-DmD16-c3    71 wing disc ML-DmD21    62 wing disc ML-DmD32    64 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    56 CNS ML-DmBG1-c1    51 CNS ML-DmBG2-c2    53 tumorous blood cells mbn2    47 ovary fGS/OSS    67 ovary OSC    92 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    47 heat shock, 4-day adult    51 Cadmium 50 mM 6 hrs, larvae L3    43 Cadmium 50 mM 12 hrs, larvae L3    79 Cadmium 50 mM 48 hrs, 4-day adult    69 Cadmium 100 mM 48 hrs, 4-day adult    108 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    100 Zinc 5 mM 12 hrs, larvae L3    59 Zinc 4.5 mM 48 hrs, 4-day adult    80 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    42 Caffeine 1.5 mg/ml 4 hrs, larvae L3    78 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    107 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    92 Paraquat 10 mM 48 hrs, 4-day adult    77 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (61) cold shock, 4-day adult  (47) heat shock, 4-day adult  (51) Cadmium 50 mM 6 hrs, larvae L3  (43) Cadmium 50 mM 12 hrs, larvae L3  (79) Cadmium 50 mM 48 hrs, 4-day adult  (69) Cadmium 100 mM 48 hrs, 4-day adult  (108) Copper 0.5 mM 12 hrs, larvae L3  (62) Copper 15 mM 48 hrs, 4-day adult  (100) Zinc 5 mM 12 hrs, larvae L3  (59) Zinc 4.5 mM 48 hrs, 4-day adult  (80) Ethanol 2.5% 3 hrs, larvae L3  (79) Ethanol 5% 3 hrs, larvae L3  (56) Ethanol 10% 3 hrs, larvae L3  (42) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (78) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (107) Caffeine 25 mg/ml 48 hrs, 4-day adult  (57) Paraquat 5 mM 48 hrs, 4-day adult  (92) Paraquat 10 mM 48 hrs, 4-day adult  (77) Rotenone 2 μg 12 hrs, larvae L3  (48) Rotenone 8 μg 12 hrs, larvae L3  (39) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    47 heat shock, 4-day adult    51 Cadmium 50 mM 6 hrs, larvae L3    43 Cadmium 50 mM 12 hrs, larvae L3    79 Cadmium 50 mM 48 hrs, 4-day adult    69 Cadmium 100 mM 48 hrs, 4-day adult  (108) Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    100 Zinc 5 mM 12 hrs, larvae L3    59 Zinc 4.5 mM 48 hrs, 4-day adult    80 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    42 Caffeine 1.5 mg/ml 4 hrs, larvae L3    78 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  107 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    92 Paraquat 10 mM 48 hrs, 4-day adult    77 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    47 heat shock, 4-day adult    51 Cadmium 50 mM 6 hrs, larvae L3    43 Cadmium 50 mM 12 hrs, larvae L3    79 Cadmium 50 mM 48 hrs, 4-day adult    69 Cadmium 100 mM 48 hrs, 4-day adult    108 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    100 Zinc 5 mM 12 hrs, larvae L3    59 Zinc 4.5 mM 48 hrs, 4-day adult    80 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    42 Caffeine 1.5 mg/ml 4 hrs, larvae L3    78 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    107 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    92 Paraquat 10 mM 48 hrs, 4-day adult    77 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    39 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    47 heat shock, 4-day adult    51 Cadmium 50 mM 6 hrs, larvae L3    43 Cadmium 50 mM 12 hrs, larvae L3    79 Cadmium 50 mM 48 hrs, 4-day adult    69 Cadmium 100 mM 48 hrs, 4-day adult    108 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    100 Zinc 5 mM 12 hrs, larvae L3    59 Zinc 4.5 mM 48 hrs, 4-day adult    80 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    42 Caffeine 1.5 mg/ml 4 hrs, larvae L3    78 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    107 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    92 Paraquat 10 mM 48 hrs, 4-day adult    77 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (61) cold shock, 4-day adult  (47) heat shock, 4-day adult  (51) Cadmium 50 mM 6 hrs, larvae L3  (43) Cadmium 50 mM 12 hrs, larvae L3  (79) Cadmium 50 mM 48 hrs, 4-day adult  (69) Cadmium 100 mM 48 hrs, 4-day adult  (108) Copper 0.5 mM 12 hrs, larvae L3  (62) Copper 15 mM 48 hrs, 4-day adult  (100) Zinc 5 mM 12 hrs, larvae L3  (59) Zinc 4.5 mM 48 hrs, 4-day adult  (80) Ethanol 2.5% 3 hrs, larvae L3  (79) Ethanol 5% 3 hrs, larvae L3  (56) Ethanol 10% 3 hrs, larvae L3  (42) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (78) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (107) Caffeine 25 mg/ml 48 hrs, 4-day adult  (57) Paraquat 5 mM 48 hrs, 4-day adult  (92) Paraquat 10 mM 48 hrs, 4-day adult  (77) Rotenone 2 μg 12 hrs, larvae L3  (48) Rotenone 8 μg 12 hrs, larvae L3  (39) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    47 heat shock, 4-day adult    51 Cadmium 50 mM 6 hrs, larvae L3    43 Cadmium 50 mM 12 hrs, larvae L3    79 Cadmium 50 mM 48 hrs, 4-day adult    69 Cadmium 100 mM 48 hrs, 4-day adult  108 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    100 Zinc 5 mM 12 hrs, larvae L3    59 Zinc 4.5 mM 48 hrs, 4-day adult    80 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    42 Caffeine 1.5 mg/ml 4 hrs, larvae L3    78 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  107 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    92 Paraquat 10 mM 48 hrs, 4-day adult    77 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    47 heat shock, 4-day adult    51 Cadmium 50 mM 6 hrs, larvae L3    43 Cadmium 50 mM 12 hrs, larvae L3    79 Cadmium 50 mM 48 hrs, 4-day adult    69 Cadmium 100 mM 48 hrs, 4-day adult    108 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    100 Zinc 5 mM 12 hrs, larvae L3    59 Zinc 4.5 mM 48 hrs, 4-day adult    80 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    56 Ethanol 10% 3 hrs, larvae L3    42 Caffeine 1.5 mg/ml 4 hrs, larvae L3    78 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    107 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    92 Paraquat 10 mM 48 hrs, 4-day adult    77 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • CG4420 GM04721 GM04037 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030753 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4420-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for rngo Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage | recessive rngoGE3956 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 rngoGD11310 Phenotype manifest in Allele female germline ring canal | germline clone rngoGE3956 oocyte nucleus | germline clone rngoGE3956
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of rngo Class Mutagen Stocks Known lesion rngoe00151 piggyBac transposase 1 -- rngoe04586 piggyBac transposase 1 -- rngoG17110 P-element activity 1 -- rngoG17397 P-element activity 1 -- rngoGE3956 amorphic allele - molecular evidence 0 Yes rngoCPTI001324 piggyBac transposase 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of rngo Class Mutagen Stocks Known lesion rngoGD11310 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes rngoD257A.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes rngoFL.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion 0 Yes rngoNIG.4420R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes rngoΔRVP.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes rngoΔUBA.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes rngoΔUBQ.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)ED7364 (Marygold et al., 2007) Df(1)FDD-0230908 (Marygold et al., 2007)
Duplicated in	Dp(1;1)FDDP-0024486 (Marygold et al., 2007) Dp(1;3)DC134 (Popodi et al., 2010-, Venken et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.4420R} NA P{UASp-rngo.D257A.GFP} NA P{UASp-rngo.FL.GFP} NA P{UASp-rngo.ΔRVP.GFP} NA P{UASp-rngo.ΔUBA.GFP} NA P{UASp-rngo.ΔUBQ.GFP} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{681.P.FSVS-1}rngoCPTI001324 NA PBac{RB}rngoe00151 NA PBac{RB}rngoe04586 NA insertion of mobile activating element P{EP}rngoG17110 NA P{EP}rngoG17397 NA P{EP}rngoGE3956 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
proteasome binding inferred from physical interaction with Pros54 (Morawe et al., 2011) ubiquitin binding inferred from direct assay (Morawe et al., 2011)
Biological Process
CV term Evidence References
female germline ring canal formation inferred from mutant phenotype (Morawe et al., 2011)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Morawe et al., 2011) nucleus inferred from direct assay (Morawe et al., 2011)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
aspartic-type endopeptidase activity inferred from electronic annotation with InterPro:IPR001995, InterPro:IPR009007, InterPro:IPR019103 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR001995, InterPro:IPR009007, InterPro:IPR019103 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
rngo anti tag coimmunoprecipitation, anti tag western blot (Morawe et al., 2011) rngo - Ada anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) rngo - Rpn10 pull down, anti tag western blot, anti bait coimmunoprecipitation (Morawe et al., 2011) rngo - Ubi-p5E anti bait coimmunoprecipitation, anti tag western blot, pull down (Morawe et al., 2011) rngo - Ubi-p63E pull down, anti tag western blot, anti bait coimmunoprecipitation (Morawe et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions rngo allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58955 DroID - A comprehensive database of gene and protein interactions. • FBgn0030753 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32616
Orthologs
OrthoDB Orthologs (29) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG64XK3S Dipteran inclusive ortholog search EOG6R50BK Insect inclusive ortholog search EOG6JHBB6 Arthropod inclusive ortholog search EOG6DZ09P Metazoa inclusive ortholog search EOG62K1K1
Orthologs in Drosophila Species (EOG64XK3S)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\rngo     Drosophila pseudoobscura pseudoobscura   Dpse\GA18170 Y
Orthologs in non-Drosophila Dipterans (EOG6R50BK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL017147
Orthologs in non-Dipteran Insects (EOG6JHBB6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC552049   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG032837   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG032646   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15978   Atta cephalotes Leafcutter ant  Acep\ACEP14682   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14305   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15222   Linepithema humile Argentine ant  Lhum\LH12174   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16395   Solenopsis invicta Red fire ant  Sinv\SINV18211   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009232   Bombyx mori Silkmoth  Bmor\BGIBMGA012323   Pediculus humanus Human body louse  Phum\PHUM396890   Tribolium castaneum Red flour beetle  Tcas\TC013702
Orthologs in non-Insect Arthropods (EOG6DZ09P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW017099
Orthologs in non-Arthropod Metazoa (EOG62K1K1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C01G5.6   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022731gn   Danio rerio Zebrafish  Drer\ENSDARG00000006477   Xenopus tropicalis Western clawed frog  Xtro\ddi2   Gallus gallus Domestic chicken  Ggal\DDI2   Mus musculus House mouse  Mmus\Ddi2   Mus musculus House mouse  Mmus\Ddi1   Rattus norvegicus Norway rat  Rnor\Ddi1   Rattus norvegicus Norway rat  Rnor\Ddi2   Homo sapiens Human  Hsap\DDI2   Homo sapiens Human  Hsap\DDI1
Human Orthologs (2)
Gene OMIM HGNC Hsap\DDI2     Hsap\DDI1
AAA Orthologs (1) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila pseudoobscura pseudoobscura Dpse\GA18170
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	33582 w* P{EP}rngoG17110 26634 w* P{EP}rngoG17397/FM6, w*
Harvard	- PBac{RB}rngoe00151 - PBac{RB}rngoe04586
VDRC	v40513 w1118 P{GD11310}v40513 v40512 w1118; P{GD11310}v40512
Genomic Clones ( 2 )
	BACR13G13 BACR47D09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 517 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT13091 GM04721
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10815 AT10879 AT21144 GH25550 GM09439 LP03694 RE25719 RE35758 RE63336 RE72329 RH06963 RH22957 RH27827 RH41730 RH73223
Other clones	37339 120941 146939 274208 524538 525538 EC051484 EC051957 EC053216 EC054208 EC054212 EC054221 EC054968 EC056358 EC056576 EK054315 EK054543 EK063202 EK145806 EK174227 EK249515 EK301741 EN05554 EN06653 FGH118B08 GM04037 RP003000056 RP003000252 RP003000357 RP003001623 RP003003565 RP003005445 RP003007815 RP003009054 RP003009280 RP003013578 RP003014305 RP003015057 RP003016101 RP003016319 RP003016867 RP003016982 RP003017835 RP003018820 RP003019082 RP003019304 RP003020334 RP003022053 RP003022580 RP003023414 RP003025597 RP003028114 RP003028157 RP003028172 RP003028679 RP003028896 RP003029763 RP003031077 RP003031447 RP003032472 RP003032663 RP003032733 RP003034136 RP003035090 RP003035478 RP003035481 RP003035649 RP003037908 RP003039386 RP003039528 RP003040655 RP003041818 RP003042250 RP003043108 RP003045356 RP003048006 RP003048635 RP003051162 RP003051904 RP003052874 RP003055299 RP003055536 RP003055596 RP003058433 RP003058626 RP003059855 RP003060674 RP003061696 RP003063332 RP003063444 RP003063478 RP003065078 RP003071838 RP003073913 RP003074110 RP003075359 RP003075587 RP003076688 RP003078148 RP003078159 RP003080486 RP003083196 RP003084763 RP003084919 RP003086919 RP003087893 RP003088314 RP003088415 RP003090886 RP003091129 RP003093445 RP003097393 RP003101936 RP003104786 RP003104956 RP003105019 RP003109488 RP003110153 RP003110345 RP003110895 RP003111024 RP003111116 RP003111854 RP003114085 RP003116683 RP003117486 RP003118266 RP003118302 RP003118931 RP003119732 RP003119745 RP003121123 RP003121160 RP003121392 RP003124460 RP003125261 RP003125667 RP003126998 RP003127480 RP003128022 RP003131666 RP003131932 RP003133846 RP003137123 RP003140263 RP003140408 RP003145714 RP003149095 RP003149592 RP003150359 RP003152387 RP003152642 RP003154648 RP003155861 RP003160610 RP003161535 RP003161741 RP003161871 RP003162879 RP003163831 RP003163916 RP003164576 RP003165572 RP003166547 RP003166931 RP003167021 RP003168451 RP003170191 RP003171010 RP003171045 RP003176939 RP003178912 RP003179344 RP003179742 RP003180910 RP003182398 RP003182426 RP003182633 RP003182911 RP003183333 RP003184232 RP003184490 RP003186111 RP003186999 RP003187053 RP003187496 RP003187553 RP003187890 RP003189011 RP003193333 RP003196925 RP003201533 RP003202042 RP003203577 RP003204952 RP003205984 RP003206532 RP003206640 RP003206875 RP003207855 RP003209885 RP003212219 RP003214109 RP003215035 RP003215461 RP003215860 RP003218065 RP003219766 RP003225571 RP003225641 RP003226978 RP003227396 RP003228717 RP003228735 RP003229505 RP003229848 RP003230222 RP003230601 RP003231597 RP003231948 RP003233790 RP003233820 RP003236242 RP003236414 RP003236863 RP003237188 RP003240205 RP003242347 RP003242984 RP003243995 RP003249290 RP003250494 RP003253174 RP003254453 RP003256089 RP003258256 RP003258884 RP003265148 RP003266113 RP003270652 RP003270837 RP003274265 RP003275626 RP003276241 RP003276895 RP003278990 RP003281618 RP003282684 RP003283844 RP003293888 RP003296295 RP003299177 RP003300298 RP003303757 RP003303778 RP003306417 RP003308639 RP003308747 RP003310364 RP003311262 RP003311419 RP003312046 RP003312091 RP003312757 RP003316457 RP003317427 RP003319583 RP003320133 RP003323934 RP003324640 RP003327321 RP003331632 RP003334021 RP003335585 RP003335610 RP003336381 RP003337399 RP003338773 RP003341106 RP003341913 RP003344002 RP003345427 RP003349480 RP003357122 RP003357165 RP003357617 RP003360243 RP003361621 RP003362589 RP003363093 RP003363552 RP003364466 RP003364547 RP003365081 RP003366185 RP003367182 RP003371889 RP003373392 RP003374210 RP003374264 RP003375420 RP003375695 RP003376060 RP003376331 RP003377723 RP003378871 RP003380833 RP003382940 RP003383391 RP003383481 RP003384963 RP003385860 RP003388430 RP003390456 RP003391020 RP003391373 RP003391641 RP003391900 RP003392325 RP003392756 RP003392824 RP003393420 RP003395696 RP003396104 RP003396654 RP003397156 RP003397905 RP003400506 RP003401172 RP003402512 RP003402946 RP003403665 RP003404289 RP003405070 RP003407361 RP003409927 RP003410170 RP003412360 RP003413622 RP003414732 RP003415542 RP003415875 RP003418666 RP003418985 RP003421375 RP003423541 RP003424869 RP003425682 RP003425947 RP003427518 RP003433126 RP003433427 RP003435911 RP003439740 RP003440139 RP003440933 RP003441423 RP003443018 RP003443201 RP003445081 RP003448260 RP003448645 RP003450174 RP003452000 RP003454111 RP003454638 RP003455549 RP003457331 RP003458714 RP003460508 RP003461494 RP003463415 RP003463578 RP003465214 RP003470597 RP003472674 RP003473342 RP003473622 RP003475493 RP003476030 RP003477227 RP003479084 RP003479224 RP003479732 RP003484715 RP003485991 RP003488037 RP003489521 RP003489539 RP003490266 RP003490356 RP003492819 RP003494363 RP003494887 RP003495928 RP003497213 RP003500262 RP003500808 RP003501817 RP003502031 RP003504293 RP003506722 RP003509098 RP003509207 RP003514779 RP003515763 RP003517845 RP003517847 RP003518205 RP003518672 RP003519057 RP003521205 RP003521466 RP003521660 RP003522105 RP003522248 RP003524235 RP003524406 RP003525319 RP003528027 RP003528461 RP003530770 RP003536402 RP003540369 RP003541302 RP003542965 RP003544430 RP003545839 RP003545865 RP003551037 RP003551610 RP003553372 RP003556259 RP003557642 RP003559355 RP003559484 RP003561339 RP003561982 RP003562926 RP003563918 RP003566974 RP003568488 RP003568940 RP003569496 RP003569647 RP003570061 RP003572248 RP003572342 RP003576458 RP003582379 RP003583252 RP003585210 RP003587819 RP003588786 RP003589376 RP003589425 RP003590855 RP003590956 RP003591410 RP003591491 RP003593378 RP003593698 RP003600419 RP003601003 RP003601600 RP003601753 RP003602178 RP003603588 RP003604483 RP003604748 RP003612079 RP003621255 RP003626245 RP003627246 RP003629298 RP003636178 RP003637082 RP003637301 RP003637695 RP003642182 RP003643435 RP003648298 RP003655994 RP003656558 RP003659546 RP003662395 RP003662650 RP003664254 RP003665225 RP003666387 RP003667887 RP003671332 RP003672084 RP003673002 RP003674931 RP003674976 RP003678051 RP003679604 UUGC1014 UUGC1156
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030753 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32616
Antibody Information
	polyclonal (Morawe et al., 2011)
Other Information
Discoverer
Etymology
	The gene is named "rings lost" after the mutant phenotype (defects in ring canal morphogenesis are seen). (Morawe et al., 2011)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: rngo CG4420 (Morawe et al., 2011)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132901 RefSeq (Proteins) • NP_573129 DDBJ / EMBL / GenBank • AA695891 AA802219 AAF48614 AAL68054 AAO74702 AJ570497 AJ570498 AJ570499 AJ570500 AJ570501 AJ570503 AJ570504 AJ570505 AJ570506 AJ570507 AJ570508 AJ570509 AJ570510 AJ570511 AJ570512 AJ570514 AJ570515 AJ570516 AJ570517 AJ570518 AJ570519 AJ570520 AJ570521 AJ570522 AW941205 AY075184 BF498657 BT006019 CZ478046 CZ482341 CZ482342 Entrez Gene - A searchable database of RefSeq genes. • 32616 UniProtKB/TrEMBL • Q9VXF9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-associated/translation elongation factor EF1B, N-terminal (IPR000449) Ubiquitin (IPR000626) Peptidase A2A, retrovirus, catalytic (IPR001995) UBA-like (IPR009060) Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (IPR015940) Ubiquitin supergroup (IPR019955) Aspartic peptidase (IPR021109) Aspartic peptidase, DDI1-type (IPR019103) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • CG4420 GM04037 GM04721
Linkouts
	BioGRID - A database of protein and genetic interactions • 58955 DroID - A comprehensive database of gene and protein interactions. • FBgn0030753 DRSC - Results from RNAi screens. • FBgn0030753 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030753 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4420-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030753 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32616 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32616 modMine - Data generated by the modENCODE project. • FBgn0030753
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG4420 (Lindsay et al., 2008, Morawe et al., 2011, Wasbrough et al., 2010, Marygold et al., 2007, Popodi et al., 2010-, Lipinszki et al., 2009, Franco et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Venken et al., 2010) rngo (Morawe et al., 2011)
Name Synonym	rings lost (Morawe et al., 2011)
Secondary FlyBase IDs
References ( 27 )
Generate a list of	All references relating to this gene ( 27 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 11 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Franco et al., 2011, Mol. Cell. Proteomics 10(5): M110.002188 A Novel Strategy to Isolate Ubiquitin Conjugates Reveals Wide Role for Ubiquitination during Neural Development. [FBrf0213919] Morawe et al., 2011, J. Cell Biol. 193(1): 71--80 Loss of the extraproteasomal ubiquitin receptor Rings lost impairs ring canal growth in Drosophila oogenesis. [FBrf0213374] Show all research papers ...