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Gene Dmel\CanA-14F

General Information
Symbol	Dmel\CanA-14F	Species	D. melanogaster
Name	Calcineurin A at 14F	Annotation symbol	CG9819
Feature type	protein_coding_gene	FlyBase ID	FBgn0030758
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	14E3-14F1	Sequence location	X:16,454,717..16,481,205 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Calcineurin A at 14F is referred to in FlyBase by the symbol Dmel\CanA-14F (CG9819, FBgn0030758). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine phosphatase activity. There is experimental evidence that it is involved in the biological process: positive regulation of NFAT protein import into nucleus; sleep. 12 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Metallophosphoesterase domain; Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1623931_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CanA-14F. Gene sequence location is X:16454717..16481205.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 14E3-14F1   Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
Experimentally Determined Cytological Location
Cytogenetic map Notes References 14D-14D     (Hong, 1995.6.28) 14D-14F   (determined by in situ hybridisation)   (Madueno et al., 1995)
Experimentally Determined Recombination Data
Location	1- (Hong, 1995.6.28)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CanA-14F for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41 Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CanA-14F-RA FBtr0074292  NM_167523   3052   584 CanA-14F-RB FBtr0074293  NM_167524   6837   584 CanA-14F-RC FBtr0305198  NM_001258788   7965   584 CanA-14F-RD FBtr0332870  NM_001272693   4008   584
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CanA-14F-PA   FBpp0074067   64.3   584   5.96     NP_727985   AAF48623 CanA-14F-PB   FBpp0074068   64.3   584   5.96     NP_727986   AAN09410 CanA-14F-PC   FBpp0293728   64.3   584   5.96     NP_001245717   AFH07430 CanA-14F-PD   FBpp0305092   64.3   584   5.96     NP_001259622   AGB95464
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48623   AE014298 AAN09410   AE014298 AFH07430   AE014298 AGB95464   AI064411   AI533092   AJ783196   AJ783197   AJ783198   AJ783199   AJ783200   AJ783201   AJ783202   AJ783203   AJ783204   AJ783205   AJ783206   AJ783207   AJ783208   AY069269   BI172431   BI231686   BI356695   BQ103226   BQ103230   BQ103616   BT004864 AAO45220   CL526030   CO156814   CO176928   CO190954   CO191419   CO271930   CO273650   CO274572   CO278567   CO279481   CO282746   CO292863   CO295782   CO297683   CO303311   CO303315   CO308480   CO320539   CO332245   CO340074   CO344554   CZ481597   CZ481598   CZ484881   CZ486318   EC073584   EC077063   EC083534   EC086605   EC090084   EC218394   EC224039   EC224572   EC226582   EC237477   EC239738   EC241455   EC243520   EC243883   EC244107   EC244481   EC245754   EC248478   EC248928   EC261259   EV582139   EV582269   EV582979   EV583173   EV594240   EV596450   S40058 AAB22468   U30493 AAC47079   U30604   Z31830
UniProtKB/Swiss-Prot	Q9VXF1
UniProtKB/TrEMBL	Q26249
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    28.875 Larval Midgut    6.9 Larval Hindgut    12.2 Larval Malpighian Tubules    7.8 Larval Fat Body    2.3 Larval Salivary Gland    37.2 Larval Trachea    22.55 Larval Carcass    13.95 Adult Head    18.2 Adult Eye    25.85 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    60.7 Adult Crop    26.7 Adult Midgut    12.1 Adult Hindgut    18.8 Adult Malpighian Tubules    4.6 Adult Fat Body    49.8 Adult Salivary Gland    58 Adult Heart    82.275 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    21.7 Adult Testis    3.3 Adult Male Accessory Gland    25.9 Adult Carcass    36.1 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    28.875 Larval Midgut    6.9 Larval Hindgut    12.2 Larval Malpighian Tubules    7.8 Larval Fat Body    2.3 Larval Salivary Gland    37.2 Larval Trachea    22.55 Larval Carcass    13.95 Adult Head    18.2 Adult Eye    25.85 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    60.7 Adult Crop    26.7 Adult Midgut    12.1 Adult Hindgut    18.8 Adult Malpighian Tubules    4.6 Adult Fat Body    49.8 Adult Salivary Gland    58 Adult Heart    82.275 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    21.7 Adult Testis    3.3 Adult Male Accessory Gland    25.9 Adult Carcass    36.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    28.875 Larval Midgut    6.9 Larval Hindgut    12.2 Larval Malpighian Tubules    7.8 Larval Fat Body    2.3 Larval Salivary Gland    37.2 Larval Trachea    22.55 Larval Carcass    13.95 Adult Head    18.2 Adult Eye    25.85 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    60.7 Adult Crop    26.7 Adult Midgut    12.1 Adult Hindgut    18.8 Adult Malpighian Tubules    4.6 Adult Fat Body    49.8 Adult Salivary Gland    58 Adult Heart    82.275 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    21.7 Adult Testis    3.3 Adult Male Accessory Gland    25.9 Adult Carcass    36.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    28.875 Larval Midgut    6.9 Larval Hindgut    12.2 Larval Malpighian Tubules    7.8 Larval Fat Body    2.3 Larval Salivary Gland    37.2 Larval Trachea    22.55 Larval Carcass    13.95 Adult Head    18.2 Adult Eye    25.85 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    60.7 Adult Crop    26.7 Adult Midgut    12.1 Adult Hindgut    18.8 Adult Malpighian Tubules    4.6 Adult Fat Body    49.8 Adult Salivary Gland    58 Adult Heart    82.275 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    21.7 Adult Testis    3.3 Adult Male Accessory Gland    25.9 Adult Carcass    36.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    28.875 Larval Midgut    6.9 Larval Hindgut    12.2 Larval Malpighian Tubules    7.8 Larval Fat Body    2.3 Larval Salivary Gland    37.2 Larval Trachea    22.55 Larval Carcass    13.95 Adult Head    18.2 Adult Eye    25.85 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    60.7 Adult Crop    26.7 Adult Midgut    12.1 Adult Hindgut    18.8 Adult Malpighian Tubules    4.6 Adult Fat Body    49.8 Adult Salivary Gland    58 Adult Heart    82.275 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    21.7 Adult Testis    3.3 Adult Male Accessory Gland    25.9 Adult Carcass    36.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    28.875 Larval Midgut    6.9 Larval Hindgut    12.2 Larval Malpighian Tubules    7.8 Larval Fat Body    2.3 Larval Salivary Gland    37.2 Larval Trachea    22.55 Larval Carcass    13.95 Adult Head    18.2 Adult Eye    25.85 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    60.7 Adult Crop    26.7 Adult Midgut    12.1 Adult Hindgut    18.8 Adult Malpighian Tubules    4.6 Adult Fat Body    49.8 Adult Salivary Gland    58 Adult Heart    82.275 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    21.7 Adult Testis    3.3 Adult Male Accessory Gland    25.9 Adult Carcass    36.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    28.875 Larval Midgut    6.9 Larval Hindgut    12.2 Larval Malpighian Tubules    7.8 Larval Fat Body    2.3 Larval Salivary Gland    37.2 Larval Trachea    22.55 Larval Carcass    13.95 Adult Head    18.2 Adult Eye    25.85 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    60.7 Adult Crop    26.7 Adult Midgut    12.1 Adult Hindgut    18.8 Adult Malpighian Tubules    4.6 Adult Fat Body    49.8 Adult Salivary Gland    58 Adult Heart    82.275 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    21.7 Adult Testis    3.3 Adult Male Accessory Gland    25.9 Adult Carcass    36.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    28.875 Larval Midgut    6.9 Larval Hindgut    12.2 Larval Malpighian Tubules    7.8 Larval Fat Body    2.3 Larval Salivary Gland    37.2 Larval Trachea    22.55 Larval Carcass    13.95 Adult Head    18.2 Adult Eye    25.85 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    60.7 Adult Crop    26.7 Adult Midgut    12.1 Adult Hindgut    18.8 Adult Malpighian Tubules    4.6 Adult Fat Body    49.8 Adult Salivary Gland    58 Adult Heart    82.275 Adult VirginFemale Spermatheca    3.6 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    21.7 Adult Testis    3.3 Adult Male Accessory Gland    25.9 Adult Carcass    36.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    18.2   NA  Eye    25.85   NA  Brain    62.4   28.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    60.7   NA  Crop    26.7   6.9  Midgut    no informative data   no informative data  Hindgut    no informative data   7.8  Malpighian Tubules    4.6   2.3  Fat Body    49.8   37.2  Salivary Gland    58   NA  Heart    82.275   22.55  Trachea    NA   NA  VirginFemale Spermatheca    3.6   NA  InseminatedFemale Spermatheca    2.6   NA  Ovary    21.7   NA  Testis    3.3   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    48 central nervous system, pupae P8    159 head, virgin 1-day female    61 head, virgin 4-day female    57 head, virgin 20-day female    23 head, mated 1-day female    72 head, mated 4-day female    59 head, mated 20-day female    25 head, mated 1-day male    82 head, mated 4-day male    98 head, mated 20-day male    71 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    17 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    31 carcass, larvae L3 wandering    23 carcass, 1-day adult    63 carcass, 4-day adult    65 carcass, 20-day adult    48 ovary, virgin 4-day female    66 ovary, mated 4-day female    121 testis, mated 4-day male    4 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3  (48) central nervous system, pupae P8  (159) head, virgin 1-day female  (61) head, virgin 4-day female  (57) head, virgin 20-day female    23 head, mated 1-day female  (72) head, mated 4-day female  (59) head, mated 20-day female    25 head, mated 1-day male  (82) head, mated 4-day male  (98) head, mated 20-day male  (71) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    17 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8  (31) carcass, larvae L3 wandering    23 carcass, 1-day adult  (63) carcass, 4-day adult  (65) carcass, 20-day adult  (48) ovary, virgin 4-day female  (66) ovary, mated 4-day female  (121) testis, mated 4-day male    4 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    48 central nervous system, pupae P8  (159) head, virgin 1-day female    61 head, virgin 4-day female    57 head, virgin 20-day female    23 head, mated 1-day female    72 head, mated 4-day female    59 head, mated 20-day female    25 head, mated 1-day male    82 head, mated 4-day male    98 head, mated 20-day male    71 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    17 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    31 carcass, larvae L3 wandering    23 carcass, 1-day adult    63 carcass, 4-day adult    65 carcass, 20-day adult    48 ovary, virgin 4-day female    66 ovary, mated 4-day female  (121) testis, mated 4-day male    4 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    48 central nervous system, pupae P8    159 head, virgin 1-day female    61 head, virgin 4-day female    57 head, virgin 20-day female    23 head, mated 1-day female    72 head, mated 4-day female    59 head, mated 20-day female    25 head, mated 1-day male    82 head, mated 4-day male    98 head, mated 20-day male    71 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    17 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    31 carcass, larvae L3 wandering    23 carcass, 1-day adult    63 carcass, 4-day adult    65 carcass, 20-day adult    48 ovary, virgin 4-day female    66 ovary, mated 4-day female    121 testis, mated 4-day male    4 accessory gland, mated 4-day male    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    48 central nervous system, pupae P8    159 head, virgin 1-day female    61 head, virgin 4-day female    57 head, virgin 20-day female    23 head, mated 1-day female    72 head, mated 4-day female    59 head, mated 20-day female    25 head, mated 1-day male    82 head, mated 4-day male    98 head, mated 20-day male    71 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    17 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    31 carcass, larvae L3 wandering    23 carcass, 1-day adult    63 carcass, 4-day adult    65 carcass, 20-day adult    48 ovary, virgin 4-day female    66 ovary, mated 4-day female    121 testis, mated 4-day male    4 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3  (48) central nervous system, pupae P8  (159) head, virgin 1-day female  (61) head, virgin 4-day female  (57) head, virgin 20-day female    23 head, mated 1-day female  (72) head, mated 4-day female  (59) head, mated 20-day female    25 head, mated 1-day male  (82) head, mated 4-day male  (98) head, mated 20-day male  (71) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    17 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8  31 carcass, larvae L3 wandering    23 carcass, 1-day adult  (63) carcass, 4-day adult  (65) carcass, 20-day adult  (48) ovary, virgin 4-day female  (66) ovary, mated 4-day female  (121) testis, mated 4-day male    4 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    48 central nervous system, pupae P8  (159) head, virgin 1-day female    61 head, virgin 4-day female    57 head, virgin 20-day female    23 head, mated 1-day female    72 head, mated 4-day female    59 head, mated 20-day female    25 head, mated 1-day male    82 head, mated 4-day male    98 head, mated 20-day male    71 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    17 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    31 carcass, larvae L3 wandering    23 carcass, 1-day adult    63 carcass, 4-day adult    65 carcass, 20-day adult    48 ovary, virgin 4-day female    66 ovary, mated 4-day female  121 testis, mated 4-day male    4 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    48 central nervous system, pupae P8    159 head, virgin 1-day female    61 head, virgin 4-day female    57 head, virgin 20-day female    23 head, mated 1-day female    72 head, mated 4-day female    59 head, mated 20-day female    25 head, mated 1-day male    82 head, mated 4-day male    98 head, mated 20-day male    71 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    17 digestive system, 20-day adult    12 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    31 carcass, larvae L3 wandering    23 carcass, 1-day adult    63 carcass, 4-day adult    65 carcass, 20-day adult    48 ovary, virgin 4-day female    66 ovary, mated 4-day female    121 testis, mated 4-day male    4 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    2 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    13 pupae 3d postWPP    23 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    10 adult female 01day    16 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (29) embryo 02-04hr    2 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    13 pupae 3d postWPP    23 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    10 adult female 01day    16 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    2 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    13 pupae 3d postWPP    23 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    10 adult female 01day    16 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    2 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    13 pupae 3d postWPP    23 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    10 adult female 01day    16 adult female 05day    19 adult female 30day    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    2 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    13 pupae 3d postWPP    23 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    10 adult female 01day    16 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  29 embryo 02-04hr    2 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    13 pupae 3d postWPP    23 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    10 adult female 01day    16 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    2 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    13 pupae 3d postWPP    23 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    10 adult female 01day    16 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    29 embryo 02-04hr    2 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    4 embryo 12-14hr    5 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    9 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    13 pupae 3d postWPP    23 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    10 adult female 01day    16 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    25 embryonic 1182-4H    27 embryonic GM2    24 embryonic Kc167    34 embryonic S1    16 embryonic S3    22 leg disc CME L1    24 wing disc CME-W2    21 wing disc ML-DmD8    19 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    25 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    37 ovary fGS/OSS    50 ovary OSC    55 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4    25 embryonic 1182-4H  (27) embryonic GM2    24 embryonic Kc167  (34) embryonic S1    16 embryonic S3    22 leg disc CME L1    24 wing disc CME-W2    21 wing disc ML-DmD8    19 wing disc ML-DmD9    22 wing disc ML-DmD16-c3  (56) wing disc ML-DmD21    25 wing disc ML-DmD32  (35) haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5  (27) mixed discs ML-DmD4-c1  (30) CNS ML-DmBG1-c1  (39) CNS ML-DmBG2-c2  (29) tumorous blood cells mbn2  (37) ovary fGS/OSS  (50) ovary OSC  (55) ovary OSS  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    25 embryonic 1182-4H    27 embryonic GM2    24 embryonic Kc167    34 embryonic S1    16 embryonic S3    22 leg disc CME L1    24 wing disc CME-W2    21 wing disc ML-DmD8    19 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    25 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    37 ovary fGS/OSS    50 ovary OSC    55 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    25 embryonic 1182-4H    27 embryonic GM2    24 embryonic Kc167    34 embryonic S1    16 embryonic S3    22 leg disc CME L1    24 wing disc CME-W2    21 wing disc ML-DmD8    19 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    25 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    37 ovary fGS/OSS    50 ovary OSC    55 ovary OSS    35 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    25 embryonic 1182-4H    27 embryonic GM2    24 embryonic Kc167    34 embryonic S1    16 embryonic S3    22 leg disc CME L1    24 wing disc CME-W2    21 wing disc ML-DmD8    19 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    25 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    37 ovary fGS/OSS    50 ovary OSC    55 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4    25 embryonic 1182-4H  27 embryonic GM2    24 embryonic Kc167  (34) embryonic S1    16 embryonic S3    22 leg disc CME L1    24 wing disc CME-W2    21 wing disc ML-DmD8    19 wing disc ML-DmD9    22 wing disc ML-DmD16-c3  (56) wing disc ML-DmD21    25 wing disc ML-DmD32  (35) haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5  27 mixed discs ML-DmD4-c1  30 CNS ML-DmBG1-c1  (39) CNS ML-DmBG2-c2  29 tumorous blood cells mbn2  (37) ovary fGS/OSS  (50) ovary OSC  (55) ovary OSS  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    25 embryonic 1182-4H    27 embryonic GM2    24 embryonic Kc167    34 embryonic S1    16 embryonic S3    22 leg disc CME L1    24 wing disc CME-W2    21 wing disc ML-DmD8    19 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    25 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    37 ovary fGS/OSS    50 ovary OSC    55 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    25 embryonic 1182-4H    27 embryonic GM2    24 embryonic Kc167    34 embryonic S1    16 embryonic S3    22 leg disc CME L1    24 wing disc CME-W2    21 wing disc ML-DmD8    19 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    25 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    37 ovary fGS/OSS    50 ovary OSC    55 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    64 cold shock, 4-day adult    44 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    99 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    190 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    96 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    77 Caffeine 25 mg/ml 48 hrs, 4-day adult    75 Paraquat 5 mM 48 hrs, 4-day adult    68 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (64) cold shock, 4-day adult  (44) heat shock, 4-day adult  (28) Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult  (40) Cadmium 100 mM 48 hrs, 4-day adult  (99) Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult  (190) Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult  (96) Ethanol 2.5% 3 hrs, larvae L3  (49) Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (77) Caffeine 25 mg/ml 48 hrs, 4-day adult  (75) Paraquat 5 mM 48 hrs, 4-day adult  (68) Paraquat 10 mM 48 hrs, 4-day adult  (44) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    64 cold shock, 4-day adult    44 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    99 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult  (190) Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    96 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    77 Caffeine 25 mg/ml 48 hrs, 4-day adult    75 Paraquat 5 mM 48 hrs, 4-day adult    68 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    64 cold shock, 4-day adult    44 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    99 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    190 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    96 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    77 Caffeine 25 mg/ml 48 hrs, 4-day adult    75 Paraquat 5 mM 48 hrs, 4-day adult    68 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    64 cold shock, 4-day adult    44 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    99 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    190 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    96 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    77 Caffeine 25 mg/ml 48 hrs, 4-day adult    75 Paraquat 5 mM 48 hrs, 4-day adult    68 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (64) cold shock, 4-day adult  (44) heat shock, 4-day adult  28 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult  (40) Cadmium 100 mM 48 hrs, 4-day adult  (99) Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult  (190) Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult  (96) Ethanol 2.5% 3 hrs, larvae L3  (49) Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (77) Caffeine 25 mg/ml 48 hrs, 4-day adult  (75) Paraquat 5 mM 48 hrs, 4-day adult  (68) Paraquat 10 mM 48 hrs, 4-day adult  (44) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    64 cold shock, 4-day adult    44 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    99 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult  (190) Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    96 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    77 Caffeine 25 mg/ml 48 hrs, 4-day adult    75 Paraquat 5 mM 48 hrs, 4-day adult    68 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    64 cold shock, 4-day adult    44 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    99 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    190 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    96 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    77 Caffeine 25 mg/ml 48 hrs, 4-day adult    75 Paraquat 5 mM 48 hrs, 4-day adult    68 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030758 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9819-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4elav-C155 CanA-14Fact.Scer\UAS.T:Hsap\MYC CanA-14FScer\UAS.T:Hsap\MYC viable CanA-14FEY08594 viable, with Scer\GAL4pnr-MD237 CanA-14FGD14690 Sterility Allele fertile CanA-14FEY08594 Other Phenotypes Allele hyperactive, with Scer\GAL4elav-C155 CanA-14FGD14690 hyperactive, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B CanA-14FScer\UAS.T:Hsap\MYC locomotor behavior defective CanA-14FKO locomotor behavior defective, with Scer\GAL4elav.PLu CanA-14FAct.Scer\UAS sleep defective CanA-14FKO sleep defective, with Scer\GAL4elav.PLu CanA-14FAct.Scer\UAS sleep defective, with Scer\GAL4elav-C155 CanA-14FGD14690 sleep defective | heat sensitive, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B CanA-14Fact.Scer\UAS.T:Hsap\MYC CanA-14FScer\UAS.T:Hsap\MYC Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of CanA-14F Class Mutagen Stocks Known lesion CanA-14Fe03848 piggyBac transposase 1 -- CanA-14FEY08594 P-element activity 1 -- CanA-14Ff02374 piggyBac transposase 1 -- CanA-14Ff03734 piggyBac transposase 0 -- CanA-14FKO ends-out gene targeting SCEI endonuclease FLPase 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CanA-14F Class Mutagen Stocks Known lesion CanA-14FGD14690 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CanA-14FHMS01880 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CanA-14Fact.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes CanA-14FAct.Scer\UAS in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes CanA-14FKK110900 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CanA-14FNIG.9819R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CanA-14FScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14690} NA P{KK110900} NA P{NIG.9819R} NA P{TRiP.HMS01880} NA P{UAS-CanA-14F.act} NA P{UAS-CanA-14F.myc} NA P{UAS-CanA-14F.N-term.myc} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CanA-14FEY08594 NA miscellaneous insertions PBac{RB}CanA-14Fe03848 NA PBac{WH}CanA-14Ff02374 NA PBac{WH}CanA-14Ff03734 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data on: 2007-10-01)
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
positive regulation of NFAT protein import into nucleus inferred from mutant phenotype (Gwack et al., 2007) sleep inferred from direct assay (Nakai et al., 2011, Tomita et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
protein serine/threonine phosphatase activity inferred from sequence or structural similarity (Chen et al., 1992) inferred from sequence or structural similarity with EMBL:X57115 (FlyBase, 1992-) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein dephosphorylation non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CanA-14F allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0030758 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 8674098 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VXF1
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (5) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM13389 Drosophila erecta Dere\GG18246 Drosophila ananassae Dana\GF20794 Drosophila willistoni Dwil\GK25243 Drosophila grimshawi Dgri\GH24889
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	17478 y1 w67c23 P{EPgy2}CanA-14FEY08594 38966 y1 sc* v1; P{TRiP.HMS01880}attP40
Harvard	- PBac{RB}CanA-14Fe03848 - PBac{WH}CanA-14Ff02374
VDRC	v30105 w1118; P{GD14690}v30105
Genomic Clones ( 1 )
	BACR29G15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 54 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM09534 RE14919
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04827 RE23303 RE42890 SD04791
Other clones	119 11473 12981 17858 21017 45510 53100 71020 72247 78042 106353 118858 120790 120992 154258 181018 275476 528270 CK01.63B.C2 Dmel_dig_001251_0627_3712 Dmel_dig_002567_0594_2082 Dmel_dig_004250_0591_3679 Dmel_dig_014419_0593_1511 Dmel_neb_008222_0932_3005 Dmel_neb_013240_0583_0888 EC30839 EK050231 EK051631 EK105218 EK111737 EK114513 EK130421 EK134636 EK161129 EK170332 EK201116 EK211559 EK240944 EK240950 EK258422 EK286027 EK302914 EN09347 EP09961 EP19505 UUGC0626 UUGC0631 UUGC1024
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030758 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 8674098
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CanA-14F CG9819 (Sullivan and Rubin, 2002)
Source for database merge of
Additional comments	The CanA-14F gene may be derived from the CanA1 gene by retroposition. (Betran et al., 2002)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_167523 NM_167524 NM_001258788 NM_001272693 RefSeq (Proteins) • NP_727985 NP_727986 NP_001245717 NP_001259622 DDBJ / EMBL / GenBank • AAB22468 AAC47079 AAF48623 AAN09410 AAO45220 AFH07430 AGB95464 AJ783196 AJ783197 AJ783198 AJ783199 AJ783200 AJ783201 AJ783202 AJ783203 AJ783204 AJ783205 AJ783206 AJ783207 AJ783208 BI172431 BT004864 CL526030 CZ481597 CZ481598 CZ484881 CZ486318 S40058 U30493 U30604 Z31830 Entrez Gene - A searchable database of RefSeq genes. • 8674098 UniProtKB/Swiss-Prot • Q9VXF1 UniProtKB/TrEMBL • Q26249
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0030758 DRSC - Results from RNAi screens. • FBgn0030758 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030758 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9819-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030758 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 8674098 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 8674098 modMine - Data generated by the modENCODE project. • FBgn0030758 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VXF1
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	canA-14F (Sullivan and Rubin, 2002) CanA-14F (Takeo et al., 2006, Stuart et al., 2007, Ha et al., 2009, Gwack et al., 2007, Tomita et al., 2011, Dijkers and O'Farrell, 2007, Nakai et al., 2011, Wheeler et al., 2004, Japanese National Institute of Genetics, 2012.5.21, Takeo et al., 2012) CG9819 (Betran et al., 2002, Sullivan and Rubin, 2002, Keleman et al., 2009.8.5, Wheeler et al., 2004, Ni et al., 2010.12.1) CnnA14D (Hong, 1995.6.28) CnnA14D(I) (Hong, 1995.6.29) D27 (Chen et al., 1992) DmCanA-14F (Cohen, 2005) PP2B (Morrison et al., 2000) PpD27   unnamed (Madueno et al., 1995)
Name Synonym	calcineurin (Dijkers and O'Farrell, 2007) Calcineurin (Dijkers and O'Farrell, 2007) Calcineurin A at 14F (Sullivan and Rubin, 2002) Protein phosphatase D27   protein phosphatase from PCR fragment D27 (Chen, 1993.1.7)
Secondary FlyBase IDs
	FBgn0005782
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 4 )
	Takeo et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(17): 6382--6389 Shaggy/glycogen synthase kinase 3β and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis. [FBrf0218117] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Nakai et al., 2011, J. Neurosci. 31(36): 12759--12766 Calcineurin and Its Regulator Sra/DSCR1 Are Essential for Sleep in Drosophila. [FBrf0215272] Tomita et al., 2011, J. Neurosci. 31(37): 13137--13146 Pan-Neuronal Knockdown of Calcineurin Reduces Sleep in the Fruit Fly, Drosophila melanogaster. [FBrf0215571] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...