FlyBase Gene Report: Dmel\mthl1

General Information

Symbol

Dmel\mthl1

Species

D. melanogaster

Name

methuselah-like 1

Annotation Symbol

CG4521

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030766

Gene Model Status

Stock Availability

8 publicly available

Gene Snapshot

methuselah-like 1 (mthl1) encodes a G protein coupled receptor (GPCR) in the Methuselah clade of GPCRs. It interacts with the secreted morphogen encoded by fog to specify patterns of epithelial tissue folding during gastrulation and wing imaginal disc folding. Upon binding to the product of fog, the product of mthl1 activates apical constriction through the Concertina-RhoGEF2-Rho pathway. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

mist

Key Links

Genomic Location

Cytogenetic map

Sequence location

X:16,640,968..16,650,309 [+]

Recombination map

1-54

RefSeq locus

NC_004354 REGION:16640968..16650309

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables G protein-coupled receptor activity

inferred from physical interaction with FLYBASE:fog; FB:FBgn0000719

(Manning et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables G protein-coupled receptor activity

inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000

(FlyBase Curators, 2008--)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

Biological Process (11 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

involved_in actin-mediated cell contraction

inferred from genetic interaction with FLYBASE:fog; FB:FBgn0000719

(Manning et al., 2013)

involved_in G protein-coupled receptor signaling pathway

inferred from direct assay

(Manning et al., 2013)

involved_in gastrulation

inferred from mutant phenotype

(Manning et al., 2013)

involved_in imaginal disc-derived wing morphogenesis

inferred from genetic interaction with FLYBASE:fog; FB:FBgn0000719

(Manning et al., 2013)

involved_in mesectoderm development

inferred from mutant phenotype

(Kerridge et al., 2016)

involved_in mesoderm migration involved in gastrulation

inferred from mutant phenotype

(Manning et al., 2013)

involved_in regulation of myosin II filament organization

inferred from mutant phenotype

(Kerridge et al., 2016)

involved_in wing disc morphogenesis

inferred from mutant phenotype

(Manning et al., 2013)

inferred from genetic interaction with FLYBASE:fog; FB:FBgn0000719

(Manning et al., 2013)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in cell surface receptor signaling pathway

inferred from electronic annotation with InterPro:IPR017981

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in determination of adult lifespan

inferred from sequence or structural similarity with UniProtKB:O97148

(assigned by UniProt )

(UniProt Curators, 2002-)

involved_in G protein-coupled receptor signaling pathway

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000

(FlyBase Curators, 2008--)

involved_in response to starvation

inferred from sequence or structural similarity with UniProtKB:O97148

(assigned by UniProt )

(UniProt Curators, 2002-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000

(FlyBase Curators, 2008--)

Gene Group (FlyBase)

METHUSELAH-TYPE RECEPTORS

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 2 family. Mth subfamily. (Q9VXD9)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

METHUSELAH-TYPE RECEPTORS -: Methuselah GPCRs are Class B GPCRs, forming the B3 subgroup. The gene family's founding member methuselah (mth) was identified as a Drosophila GPCR involved in the modulation of life span and stress response. No counterpart for the methuselah gene family have been identified in vertebrates. (Adapted from FBrf0129744 and FBrf0218628).

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\mthl1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0074314

4471

676

FBtr0340150

5083

676

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0074089

74.5

676

7.24

FBpp0309136

74.5

676

7.24

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

676 aa isoforms: mthl1-PA, mthl1-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mthl1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

mthl1_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

wing disc | restricted

(Manning et al., 2013)

embryonic stage 4 -- 8

(Patel et al., 2012)

cephalic furrow

(Patel et al., 2012)

embryonic stage 4

(Patel et al., 2012)

embryonic stage 5 -- 8

amnioproctodeal invagination

(Patel et al., 2012)

embryonic stage

embryonic/larval gut

(Patel et al., 2012)

embryonic stage 11

visceral mesoderm

(Patel et al., 2012)

embryonic/larval epidermis

(Patel et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Patel et al., 2012)

embryonic/larval hindgut

(Patel et al., 2012)

embryonic stage 13

embryonic/larval Malpighian tubule

(Patel et al., 2012)

embryonic stage 16

embryonic/larval foregut

(Patel et al., 2012)

embryonic/larval pharynx

(Patel et al., 2012)

embryonic/larval proventriculus

(Patel et al., 2012)

embryonic/larval esophagus

(Patel et al., 2012)

(Patel et al., 2012)

Additional Descriptive Data

mthl1 transcripts are observed in stripes that correlate with the folds of the wing disc. They are enriched on the apical sides of the folds.

(Manning et al., 2013)

mthl1 expression is detected at stage 4 along the ventral surface including the cephalic furrow and extending around the posterior pole with expression visible in the proctodeal invagination during stage 5. By stage 8, it is observed in the cephalic furrow, proctodeum, and ventral mesoderm. In stage 11, expression is seen in the visceral mesoderm and epidermis. mthl1 is detected later in the emerging midgut, hindgut, and four Malpighian tubules ending in expression in the hindgut and portions of the foregut.

(Patel et al., 2012)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mthl1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mthl1

View exonic expression by tissue for Dmel\mthl1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030766

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0030766

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4521-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4521

Flygut - An atlas of the Drosophila adult midgut

FBgn0030766

Images

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mthl1

Transgenic constructs containing regulatory region of mthl1

Deletions and Duplications ( 1 )

Partially disrupted in

(Manning et al., 2013, Rogers, 2013.8.12)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Mef2.PR

mthl1^GD727

mthl1^EY16157

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

mthl1^GD727

viable, with Scer\GAL4^pnr-MD237

mthl1^GD727

Sterility

Allele

mthl1^EY16157

Phenotype manifest in

Allele

mesoderm, with Scer\GAL4^{VP16.mat.αTub67C}

mthl1^HMS02327

wing disc, with Scer\GAL4^A9

mthl1^KK111116

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (19)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

2 of 15

Yes

No

2 of 15

Yes

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (13)

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

Xenopus tropicalis (Western clawed frog) (8)

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

No

1 of 12

Yes

No

1 of 12

Yes

Yes

Danio rerio (Zebrafish) (35)

2 of 15

Yes

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

Drer\LOC100535070

1 of 15

No

No

Drer\LOC101884341

1 of 15

No

No

Drer\LOC101886975

1 of 15

No

No

Drer\LOC103909389

1 of 15

No

Yes

Drer\LOC103911493

1 of 15

No

Yes

Drer\LOC108181087

1 of 15

No

Yes

Drer\LOC108182851

1 of 15

No

Yes

Drer\LOC110439896

1 of 15

No

Yes

Drer\LOC110439897

1 of 15

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

2 of 15

Yes

No

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904D7 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00008212

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501Z6 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY008316

Mayetiola destructor

Hessian fly

Mdes\Mdes010038

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ019111

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0CKX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA002851

Danaus plexippus

Monarch butterfly

Dple\DPOGS204753-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL015037

Apis florea

Little honeybee

Aflo\4356858980

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002321

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002327

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG002912

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM063410

Rhodnius prolixus

Kissing bug

Rpro\RPRC013152

Rhodnius prolixus

Kissing bug

Rpro\RPRC004455

Rhodnius prolixus

Kissing bug

Rpro\RPRC009650

Rhodnius prolixus

Kissing bug

Rpro\RPRC004579

Rhodnius prolixus

Kissing bug

Rpro\RPRC006170

Rhodnius prolixus

Kissing bug

Rpro\RPRC011006

Rhodnius prolixus

Kissing bug

Rpro\RPRC005437

Rhodnius prolixus

Kissing bug

Rpro\RPRC004152

Rhodnius prolixus

Kissing bug

Rpro\RPRC010938

Rhodnius prolixus

Kissing bug

Rpro\RPRC009272

Rhodnius prolixus

Kissing bug

Rpro\RPRC003050

Rhodnius prolixus

Kissing bug

Rpro\RPRC010887

Rhodnius prolixus

Kissing bug

Rpro\RPRC014426

Rhodnius prolixus

Kissing bug

Rpro\RPRC006777

Rhodnius prolixus

Kissing bug

Rpro\RPRC002490

Rhodnius prolixus

Kissing bug

Rpro\RPRC001933

Rhodnius prolixus

Kissing bug

Rpro\RPRC010653

Rhodnius prolixus

Kissing bug

Rpro\RPRC008417

Rhodnius prolixus

Kissing bug

Rpro\RPRC014542

Rhodnius prolixus

Kissing bug

Rpro\RPRC014540

Rhodnius prolixus

Kissing bug

Rpro\RPRC000600

Rhodnius prolixus

Kissing bug

Rpro\RPRC013536

Cimex lectularius

Bed bug

Clec\CLEC004959

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008388

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09249

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CJ1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR001897

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_252060

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0JXY )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_022042gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_7282

Ciona intestinalis

Vase tunicate

Ciona intestinalis

Vase tunicate

Cint\LOC100185099

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (24)

Gene Symbol

Score

Source

Alignment

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Manning et al., 2013)

suppressible

(Chai et al., 2019)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0030766

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

X

Recombination map

1-54

Cytogenetic map

Sequence location

X:16,640,968..16,650,309 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

14F4-14F5

Limits computationally determined from genome sequence between P{EP}EP1547^EP1547 and P{EP}CG4928^EP1341

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-54

(FlyBase, 2016)

1-55.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

41930

y¹ v¹; P{TRiP.HMS02327}attP40

59148

y¹ w^* Mi{MIC}mthl1^MI13496

21192

y¹ w^67c23 P{EPgy2}mthl1^EY16157

57699

y¹ sc^* v¹ sev²¹; P{TRiP.GLC01865}attP2/TM3, Sb¹

51320

Df(1)YO17, y¹ w^67c23 mthl1^YO17/FM7c, P{GAL4-twi.G}108.4, P{UAS-2xEGFP}AX

v107488

P{KK111116}VIE-260B

v33135

w¹¹¹⁸; P{GD727}v33135

v33136

w¹¹¹⁸; P{GD727}v33136/CyO

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (95)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE13854

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030766

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030766

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32637

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Manning et al., 2013)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: mthl1 anon-WO0170980.22 anon-WO0170980.23

(FlyBase, 1996-)

Additional comments

Source for merge of mthl1 anon-WO0170980.22 anon-WO0170980.23 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 32 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32637

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VXD9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2JC86

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030766

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030766

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

mthl1_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4521

Flygut - An atlas of the Drosophila adult midgut

FBgn0030766

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32637

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4521

modMine - A data warehouse for the modENCODE project

FBgn0030766

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0030766

DRSC - Results frm RNAi screens

FBgn0030766

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0030766

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4521-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030766

FlyMine - An integrated database for Drosophila genomics

FBgn0030766

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG4521

(Friedrich and Jones, 2016, Li et al., 2013, Manning et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Harmar, 2001)

Mist

(Gilmour et al., 2017, Kerridge et al., 2016)

Mth-1

(Cvejic et al., 2004)

anon-WO0170980.22

anon-WO0170980.23

mist

(Martin, 2020, Bakopoulos et al., 2019, Chai et al., 2019, Johnson and Toettcher, 2019, Lim et al., 2017, Urbansky et al., 2016, Nie et al., 2014, Manning et al., 2013)

mthl1

(Moskalev et al., 2018, Friedrich and Jones, 2016, Dobson et al., 2015, Araújo et al., 2013, Li et al., 2013, Rogers, 2013.8.12, Japanese National Institute of Genetics, 2012.5.21, Patel et al., 2012, Ja et al., 2009)

Name Synonyms

Mesoderm-invagination signal transducer

(Martin, 2020)

Mth-like 1

(West et al., 2001)

mesoderm-invagination signal transducer

(Manning et al., 2013)

methuselah-like 1

mth-like 1

(Brody and Cravchik, 2000)

Secondary FlyBase IDs

FBgn0046548
FBgn0046549

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (51)