FB2019_05, released Oct 15, 2019

Gene: Dmel\mthl1

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General Information
Symbol
Dmel\mthl1
Species
D. melanogaster
Name
methuselah-like 1
Annotation Symbol
CG4521
Feature Type
protein_coding_gene
FlyBase ID
FBgn0030766
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
methuselah-like 1 (mthl1) encodes a G protein coupled receptor (GPCR) in the Methuselah clade of GPCRs. It interacts with the secreted morphogen encoded by fog to specify patterns of epithelial tissue folding during gastrulation and wing imaginal disc folding. Upon binding to the product of fog, the product of mthl1 activates apical constriction through the Concertina-RhoGEF2-Rho pathway. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
mist
Key Links
Genomic Location
Cytogenetic map
14F4-14F5
Sequence location
X:16,640,968..16,650,309 [+]
Recombination map
1-54
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor 2 family. Mth subfamily. (Q9VXD9)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
G protein-coupled receptor activity
Predictions / Assertions
G protein-coupled receptor activity
Summaries
Gene Group (FlyBase)
METHUSELAH-TYPE RECEPTORS -
Methuselah GPCRs are Class B GPCRs, forming the B3 subgroup. The gene family's founding member methuselah (mth) was identified as a Drosophila GPCR involved in the modulation of life span and stress response. No counterpart for the methuselah gene family have been identified in vertebrates. (Adapted from FBrf0129744 and FBrf0218628).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\mthl1 or the JBrowse view of Dmel\mthl1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.50
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mthl1-RA
FBtr0074314
NM_132912
4471
676
mthl1-RB
FBtr0340150
NM_001298411
5083
676
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
mthl1-PA
FBpp0074089
74.5
676
7.24
NP_573140
AAF48635
mthl1-PB
FBpp0309136
74.5
676
7.24
NP_001285340
AHN59810
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

676 aa isoforms: mthl1-PA, mthl1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mthl1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (13 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
G protein-coupled receptor activity
inferred from physical interaction with FLYBASE:fog; FB:FBgn0000719
(Manning et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
G protein-coupled receptor activity
inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000
(FlyBase Curators, 2008--)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
Biological Process (11 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
actin-mediated cell contraction
inferred from genetic interaction with FLYBASE:fog; FB:FBgn0000719
(Manning et al., 2013)
G protein-coupled receptor signaling pathway
inferred from direct assay
(Manning et al., 2013)
gastrulation
inferred from mutant phenotype
(Manning et al., 2013)
imaginal disc-derived wing morphogenesis
inferred from genetic interaction with FLYBASE:fog; FB:FBgn0000719
(Manning et al., 2013)
mesectoderm development
inferred from mutant phenotype
(Kerridge et al., 2016)
mesoderm migration involved in gastrulation
inferred from mutant phenotype
(Manning et al., 2013)
regulation of myosin II filament organization
inferred from mutant phenotype
(Kerridge et al., 2016)
wing disc morphogenesis
inferred from mutant phenotype
(Manning et al., 2013)
inferred from genetic interaction with FLYBASE:fog; FB:FBgn0000719
(Manning et al., 2013)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
cell surface receptor signaling pathway
inferred from electronic annotation with InterPro:IPR017981
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
determination of adult lifespan
inferred from sequence or structural similarity with UniProtKB:O97148
(assigned by UniProt )
(UniProt Curators, 2002-)
G protein-coupled receptor signaling pathway
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000
(FlyBase Curators, 2008--)
response to starvation
inferred from sequence or structural similarity with UniProtKB:O97148
(assigned by UniProt )
(UniProt Curators, 2002-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
integral component of membrane
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000
(FlyBase Curators, 2008--)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval gut
(Patel et al., 2012)
embryonic stage 4
hindgut anlage
(Patel et al., 2012)
embryonic stage 4 -- 8
mesoderm
(Patel et al., 2012)
cephalic furrow
(Patel et al., 2012)
embryonic stage 5 -- 8
amnioproctodeal invagination
(Patel et al., 2012)
embryonic stage 11
visceral mesoderm
(Patel et al., 2012)
embryonic/larval epidermis
(Patel et al., 2012)
embryonic stage 13
embryonic/larval Malpighian tubule
(Patel et al., 2012)
embryonic stage 13 -- 16
embryonic/larval midgut
(Patel et al., 2012)
embryonic/larval hindgut
(Patel et al., 2012)
embryonic stage 16
embryonic/larval foregut
(Patel et al., 2012)
embryonic/larval pharynx
(Patel et al., 2012)
embryonic/larval proventriculus
(Patel et al., 2012)
embryonic/larval esophagus
(Patel et al., 2012)
cercus
(Patel et al., 2012)
third instar larval stage
wing disc | restricted
(Manning et al., 2013)
Additional Descriptive Data
mthl1 transcripts are observed in stripes that correlate with the folds of the wing disc. They are enriched on the apical sides of the folds.
(Manning et al., 2013)
mthl1 expression is detected at stage 4 along the ventral surface including the cephalic furrow and extending around the posterior pole with expression visible in the proctodeal invagination during stage 5. By stage 8, it is observed in the cephalic furrow, proctodeum, and ventral mesoderm. In stage 11, expression is seen in the visceral mesoderm and epidermis. mthl1 is detected later in the emerging midgut, hindgut, and four Malpighian tubules ending in expression in the hindgut and portions of the foregut.
(Patel et al., 2012)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mthl1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mthl1
Transgenic constructs containing regulatory region of mthl1
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Mef2.PR
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
Phenotype manifest in
Allele
mesoderm, with Scer\GAL4VP16.mat.αTub67C
wing disc, with Scer\GAL4A9
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (23)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ADGRD1
1 of 15
Yes
No
Hsap\ADGRD2
1 of 15
Yes
Yes
Hsap\ADGRE1
1 of 15
No
Yes
Hsap\ADGRE2
1 of 15
No
Yes
Hsap\ADGRE3
1 of 15
Yes
No
Hsap\ADGRE5
1 of 15
No
Yes
Hsap\ADGRF1
1 of 15
Yes
No
Hsap\ADGRF2
1 of 15
Yes
Yes
Hsap\ADGRF3
1 of 15
Yes
Yes
Hsap\ADGRF4
1 of 15
Yes
Yes
Hsap\ADGRF5
1 of 15
Yes
No
Hsap\ADGRG1
1 of 15
No
Yes
Hsap\ADGRG2
1 of 15
No
Yes
Hsap\ADGRG3
1 of 15
Yes
No
Hsap\ADGRG4
1 of 15
Yes
No
Hsap\ADGRG5
1 of 15
Yes
No
Hsap\ADGRG6
1 of 15
Yes
No
Hsap\ADGRG7
1 of 15
Yes
No
Hsap\ADGRL1
1 of 15
No
Yes
Hsap\ADGRL2
1 of 15
No
Yes
Hsap\ADGRL3
1 of 15
No
Yes
Hsap\ADGRL4
1 of 15
Yes
No
Hsap\FBN3
1 of 15
Yes
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Adgre1
2 of 15
No
Yes
Mmus\Adgre5
2 of 15
Yes
Yes
Mmus\Adgrd1
1 of 15
No
No
Mmus\Adgre4
1 of 15
No
No
Mmus\Adgrf1
1 of 15
No
No
Mmus\Adgrf2
1 of 15
No
Yes
Mmus\Adgrf3
1 of 15
No
Yes
Mmus\Adgrf4
1 of 15
No
Yes
Mmus\Adgrf5
1 of 15
No
No
Mmus\Adgrg1
1 of 15
No
No
Mmus\Adgrg2
1 of 15
No
No
Mmus\Adgrg3
1 of 15
No
No
Mmus\Adgrg4
1 of 15
No
No
Mmus\Adgrg5
1 of 15
No
No
Mmus\Adgrg6
1 of 15
No
No
Mmus\Adgrg7
1 of 15
No
No
Mmus\Adgrl1
1 of 15
No
No
Mmus\Adgrl2
1 of 15
No
No
Mmus\Adgrl3
1 of 15
No
No
Mmus\Adgrl4
1 of 15
No
No
Rattus norvegicus (Norway rat) (13)
Rnor\Adgrd1
1 of 13
Yes
No
Rnor\Adgre1
1 of 13
Yes
No
Rnor\Adgre5
1 of 13
Yes
No
Rnor\Adgrf2
1 of 13
Yes
Yes
Rnor\Adgrf3
1 of 13
Yes
Yes
Rnor\Adgrf4
1 of 13
Yes
Yes
Rnor\Adgrf5
1 of 13
Yes
Yes
Rnor\Adgrg2
1 of 13
Yes
No
Rnor\Adgrg3
1 of 13
Yes
No
Rnor\Adgrg5
1 of 13
Yes
No
Rnor\Adgrg6
1 of 13
Yes
No
Rnor\Adgrg7
1 of 13
Yes
No
Rnor\Adgrl2
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (7)
Xtro\adgrd1
1 of 12
Yes
Yes
Xtro\adgre5
1 of 12
Yes
Yes
Xtro\adgrf1
1 of 12
Yes
Yes
Xtro\adgrf3
1 of 12
Yes
Yes
Xtro\adgrg1
1 of 12
Yes
Yes
Xtro\adgrl1
1 of 12
Yes
No
Xtro\adgrv1
1 of 12
Yes
No
Danio rerio (Zebrafish) (23)
Drer\adgrd2
1 of 15
Yes
Yes
Drer\adgre5b.3
1 of 15
Yes
No
Drer\adgre10
1 of 15
Yes
No
Drer\adgre14
1 of 15
Yes
No
Drer\adgrf3a
1 of 15
Yes
Yes
Drer\adgrf6
1 of 15
Yes
Yes
Drer\adgrf11
1 of 15
Yes
Yes
Drer\adgrg1
1 of 15
Yes
No
Drer\adgrg2a
1 of 15
Yes
No
Drer\adgrg3
1 of 15
Yes
No
Drer\adgrg4a
1 of 15
Yes
No
Drer\adgrg6
1 of 15
Yes
No
Drer\adgrg11
1 of 15
Yes
No
Drer\adgrl1a
1 of 15
Yes
No
Drer\adgrl2a
1 of 15
Yes
No
Drer\adgrl3.1
1 of 15
Yes
No
Drer\adgrl4
1 of 15
Yes
No
Drer\fbn2a
1 of 15
Yes
Yes
Drer\fbn2b
1 of 15
Yes
Yes
Drer\LOC100535070
1 of 15
Yes
No
Drer\LOC100538279
1 of 15
Yes
No
Drer\LOC101884341
1 of 15
Yes
No
Drer\LOC101886975
1 of 15
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\lat-2
2 of 15
Yes
No
Cele\lat-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091904D7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\mthl1
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008212
Drosophila simulans
Dsim\GD17291
Drosophila sechellia
Dsec\GM13452
Drosophila erecta
Dere\GG19062
Drosophila yakuba
Dyak\GE17283
Drosophila ananassae
Dana\GF20388
Drosophila pseudoobscura pseudoobscura
Dpse\GA18231
Drosophila persimilis
Dper\GL20280
Drosophila willistoni
Dwil\GK17202
Drosophila virilis
Dvir\GJ14760
Drosophila mojavensis
Dmoj\GI15323
Drosophila grimshawi
Dgri\GH24384
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501Z6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012712
Glossina morsitans
Tsetse fly
Gmor\GMOY008316
Mayetiola destructor
Hessian fly
Mdes\Mdes010038
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019111
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0CKX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002851
Danaus plexippus
Monarch butterfly
Dple\DPOGS204753-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015037
Apis florea
Little honeybee
Aflo\4356858980
Apis mellifera
Western honey bee
Amel\LOC724853
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11226
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11225
Bombus terrestris
Buff-tailed bumblebee
Bter\15215393
Linepithema humile
Argentine ant
Lhum\LH24832
Linepithema humile
Argentine ant
Lhum\LH24829
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002321
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002327
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002912
Tribolium castaneum
Red flour beetle
Tcas\TC010654
Pediculus humanus
Human body louse
Phum\PHUM063410
Rhodnius prolixus
Kissing bug
Rpro\RPRC013152
Rhodnius prolixus
Kissing bug
Rpro\RPRC004455
Rhodnius prolixus
Kissing bug
Rpro\RPRC009650
Rhodnius prolixus
Kissing bug
Rpro\RPRC004579
Rhodnius prolixus
Kissing bug
Rpro\RPRC006170
Rhodnius prolixus
Kissing bug
Rpro\RPRC011006
Rhodnius prolixus
Kissing bug
Rpro\RPRC005437
Rhodnius prolixus
Kissing bug
Rpro\RPRC004152
Rhodnius prolixus
Kissing bug
Rpro\RPRC010938
Rhodnius prolixus
Kissing bug
Rpro\RPRC009272
Rhodnius prolixus
Kissing bug
Rpro\RPRC003050
Rhodnius prolixus
Kissing bug
Rpro\RPRC010887
Rhodnius prolixus
Kissing bug
Rpro\RPRC014426
Rhodnius prolixus
Kissing bug
Rpro\RPRC006777
Rhodnius prolixus
Kissing bug
Rpro\RPRC002490
Rhodnius prolixus
Kissing bug
Rpro\RPRC001933
Rhodnius prolixus
Kissing bug
Rpro\RPRC010653
Rhodnius prolixus
Kissing bug
Rpro\RPRC008417
Rhodnius prolixus
Kissing bug
Rpro\RPRC014542
Rhodnius prolixus
Kissing bug
Rpro\RPRC014540
Rhodnius prolixus
Kissing bug
Rpro\RPRC000600
Rhodnius prolixus
Kissing bug
Rpro\RPRC013536
Cimex lectularius
Bed bug
Clec\CLEC004959
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008388
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09249
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CJ1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR001897
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_252060
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0JXY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_022042gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_7282
Ciona intestinalis
Vase tunicate
Cint\LOC494377
Ciona intestinalis
Vase tunicate
Cint\LOC100185099
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (17)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
mthl2
2 of 10
mthl3
2 of 10
mthl4
2 of 10
mthl10
2 of 10
mth
2 of 10
CG11318
1 of 10
CG15556
1 of 10
CG43968
1 of 10
Cirl
1 of 10
mthl6
1 of 10
mthl7
1 of 10
mthl8
1 of 10
mthl9
1 of 10
mthl11
1 of 10
mthl12
1 of 10
mthl13
1 of 10
mthl15
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    fog
    suppressible
    mthl1
    (Manning et al., 2013)
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-54
    Cytogenetic map
    14F4-14F5
    Sequence location
    X:16,640,968..16,650,309 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    14F4-14F5
    Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location
    1-54
    (FlyBase, 2016)
    1-55.7
    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (8)
    Genomic Clones (12)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (95)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      polyclonal
      (Manning et al., 2013)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of
      Source for merge of: mthl1 anon-WO0170980.22 anon-WO0170980.23
      (FlyBase, 1996-)
      Additional comments
      Source for merge of mthl1 anon-WO0170980.22 anon-WO0170980.23 was sequence comparison ( date:051113 ).
      (FlyBase, 1996-)
      Other Comments
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 31 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyMine - An integrated database for Drosophila genomics
      Synonyms and Secondary IDs (11)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (47)