FlyBase Gene Report: Dmel\mthl1

General Information

Symbol

Dmel\mthl1

Species

D. melanogaster

Name

methuselah-like 1

Annotation Symbol

CG4521

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030766

Gene Model Status

Stock Availability

7 publicly available

Gene Summary

methuselah-like 1 (mthl1) encodes a G protein coupled receptor (GPCR) in the Methuselah clade of GPCRs. It interacts with the secreted morphogen encoded by fog to specify patterns of epithelial tissue folding during gastrulation and wing imaginal disc folding. Upon binding to the product of fog, the product of mthl1 activates apical constriction through the Concertina-RhoGEF2-Rho pathway. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

mist

Key Links

Genomic Location

Cytogenetic map

Sequence location

X:16,640,968..16,650,309 [+]

Recombination map

1-54

RefSeq locus

NC_004354 REGION:16640968..16650309

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables G protein-coupled receptor activity

inferred from physical interaction with FLYBASE:fog; FB:FBgn0000719

(Manning et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables G protein-coupled receptor activity

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000

(FlyBase Curators, 2008-)

Biological Process (11 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

involved_in actin-mediated cell contraction

inferred from genetic interaction with FLYBASE:fog; FB:FBgn0000719

(Manning et al., 2013)

involved_in G protein-coupled receptor signaling pathway

inferred from direct assay

(Manning et al., 2013)

involved_in gastrulation

inferred from mutant phenotype

(Manning et al., 2013)

involved_in imaginal disc-derived wing morphogenesis

inferred from genetic interaction with FLYBASE:fog; FB:FBgn0000719

(Manning et al., 2013)

involved_in mesectoderm development

inferred from mutant phenotype

(Kerridge et al., 2016)

involved_in mesoderm migration involved in gastrulation

inferred from mutant phenotype

(Manning et al., 2013)

involved_in regulation of myosin II filament organization

inferred from mutant phenotype

(Kerridge et al., 2016)

involved_in wing disc morphogenesis

inferred from mutant phenotype

(Manning et al., 2013)

inferred from genetic interaction with FLYBASE:fog; FB:FBgn0000719

(Manning et al., 2013)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in cell surface receptor signaling pathway

inferred from electronic annotation with InterPro:IPR017981

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in determination of adult lifespan

inferred from sequence or structural similarity with UniProtKB:O97148

(assigned by UniProt )

(UniProt Curators, 2002-)

involved_in G protein-coupled receptor signaling pathway

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000

(FlyBase Curators, 2008-)

involved_in response to starvation

inferred from sequence or structural similarity with UniProtKB:O97148

(assigned by UniProt )

(UniProt Curators, 2002-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence or structural similarity with FLYBASE:mth; FB:FBgn0023000

(FlyBase Curators, 2008-)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

Gene Group (FlyBase)

METHUSELAH-TYPE RECEPTORS

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 2 family. Mth subfamily. (Q9VXD9)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

methuselah-like 1 (mthl1) encodes a G protein coupled receptor (GPCR) in the Methuselah clade of GPCRs. It interacts with the secreted morphogen encoded by fog to specify patterns of epithelial tissue folding during gastrulation and wing imaginal disc folding. Upon binding to the product of fog, the product of mthl1 activates apical constriction through the Concertina-RhoGEF2-Rho pathway. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

METHUSELAH-TYPE RECEPTORS -: Methuselah GPCRs are Class B GPCRs, forming the B3 subgroup. The gene family's founding member methuselah (mth) was identified as a Drosophila GPCR involved in the modulation of life span and stress response. No counterpart for the methuselah gene family have been identified in vertebrates. (Adapted from FBrf0129744 and FBrf0218628).

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\mthl1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VXD9)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0074314

4471

676

FBtr0340150

5083

676

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0074089

74.5

676

7.24

FBpp0309136

74.5

676

7.24

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

676 aa isoforms: mthl1-PA, mthl1-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mthl1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

mthl1_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic/larval gut

(Patel et al., 2012)

embryonic stage 4

(Patel et al., 2012)

embryonic stage 4 -- 8

(Patel et al., 2012)

cephalic furrow

(Patel et al., 2012)

embryonic stage 5 -- 8

amnioproctodeal invagination

(Patel et al., 2012)

embryonic stage 11

visceral mesoderm

(Patel et al., 2012)

embryonic/larval epidermis

(Patel et al., 2012)

embryonic stage 13

embryonic/larval Malpighian tubule

(Patel et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Patel et al., 2012)

embryonic/larval hindgut

(Patel et al., 2012)

embryonic stage 16

embryonic/larval foregut

(Patel et al., 2012)

embryonic/larval pharynx

(Patel et al., 2012)

embryonic/larval proventriculus

(Patel et al., 2012)

embryonic/larval esophagus

(Patel et al., 2012)

(Patel et al., 2012)

third instar larval stage

wing disc | restricted

(Manning et al., 2013)

Additional Descriptive Data

mthl1 transcripts are observed in stripes that correlate with the folds of the wing disc. They are enriched on the apical sides of the folds.

(Manning et al., 2013)

mthl1 expression is detected at stage 4 along the ventral surface including the cephalic furrow and extending around the posterior pole with expression visible in the proctodeal invagination during stage 5. By stage 8, it is observed in the cephalic furrow, proctodeum, and ventral mesoderm. In stage 11, expression is seen in the visceral mesoderm and epidermis. mthl1 is detected later in the emerging midgut, hindgut, and four Malpighian tubules ending in expression in the hindgut and portions of the foregut.

(Patel et al., 2012)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mthl1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mthl1

View exonic expression by tissue for Dmel\mthl1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030766

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32637/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030766

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030766

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030766

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4521

Flygut - An atlas of the Drosophila adult midgut

FBgn0030766

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mthl1

Transgenic constructs containing regulatory region of mthl1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

(Manning et al., 2013, Rogers, 2013.8.12)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Mef2.PR

mthl1^GD727

mthl1^EY16157

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

mthl1^GD727

viable, with Scer\GAL4^pnr-MD237

mthl1^GD727

Sterility

Allele

mthl1^EY16157

Phenotype manifest in

Allele

mesoderm, with Scer\GAL4^{VP16.mat.αTub67C}

mthl1^HMS02327

wing disc, with Scer\GAL4^A9

mthl1^KK111116

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

Yes

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

1 of 15

Yes

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (19)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

2 of 15

Yes

No

2 of 15

Yes

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (13)

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

Xenopus tropicalis (Western clawed frog) (8)

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

Yes

1 of 12

Yes

No

1 of 12

Yes

No

1 of 12

Yes

Yes

Danio rerio (Zebrafish) (35)

2 of 15

Yes

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

Drer\LOC100535070

1 of 15

No

No

Drer\LOC101884341

1 of 15

No

No

Drer\LOC101886975

1 of 15

No

No

Drer\LOC103909389

1 of 15

No

Yes

Drer\LOC103911493

1 of 15

No

Yes

Drer\LOC108181087

1 of 15

No

Yes

Drer\LOC108182851

1 of 15

No

Yes

Drer\LOC110439896

1 of 15

No

Yes

Drer\LOC110439897

1 of 15

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

2 of 15

Yes

No

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (24)

Gene Symbol

Score

Source

Alignment

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Manning et al., 2013)

suppressible

(Chai et al., 2019)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0030766

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

X

Recombination map

1-54

Cytogenetic map

Sequence location

X:16,640,968..16,650,309 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

14F4-14F5

Limits computationally determined from genome sequence between P{EP}EP1547^EP1547 and P{EP}CG4928^EP1341

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-54

(FlyBase, 2016)

1-55.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

41930

y¹ v¹; P{TRiP.HMS02327}attP40

59148

y¹ w^* Mi{MIC}mthl1^MI13496

21192

y¹ w^67c23 P{EPgy2}mthl1^EY16157

57699

y¹ sc^* v¹ sev²¹; P{TRiP.GLC01865}attP2/TM3, Sb¹

51320

Df(1)YO17, y¹ w^67c23 mthl1^YO17/FM7c, P{GAL4-twi.G}108.4, P{UAS-2xEGFP}AX

v107488

P{KK111116}VIE-260B

v33135

w¹¹¹⁸; P{GD727}v33135

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (95)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE13854

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030766

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030766

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32637

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Manning et al., 2013)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: mthl1 anon-WO0170980.22 anon-WO0170980.23

(FlyBase, 1996-)

Additional comments

Source for merge of mthl1 anon-WO0170980.22 anon-WO0170980.23 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32637

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VXD9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VXD9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2JC86

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VXD9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030766

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030766

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32637/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030766

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

mthl1_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030766

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030766

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4521

Flygut - An atlas of the Drosophila adult midgut

FBgn0030766

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32637

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4521

MARRVEL_MODEL - MARRVEL (model organism gene)

32637

modMine - A data warehouse for the modENCODE project

FBgn0030766

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0030766

DRSC - Results frm RNAi screens

FBgn0030766

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030766

FlyMine - An integrated database for Drosophila genomics

FBgn0030766

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG4521

(Friedrich and Jones, 2016, Li et al., 2013, Manning et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Harmar, 2001)

Mist

(Loganathan et al., 2021, Gheisari et al., 2020, Perez-Vale and Peifer, 2020, Rich et al., 2020, Stathopoulos and Newcomb, 2020, Gilmour et al., 2017, Kerridge et al., 2016)

Mth-1

(Cvejic et al., 2004)

anon-WO0170980.22

anon-WO0170980.23

mist

(Hayashi and Ogura, 2020, Martin, 2020, Bakopoulos et al., 2019, Chai et al., 2019, Johnson and Toettcher, 2019, Lim et al., 2017, Urbansky et al., 2016, Nie et al., 2014, Manning et al., 2013)

mthl1

(Liu et al., 2021, Moskalev et al., 2018, Friedrich and Jones, 2016, Dobson et al., 2015, Araújo et al., 2013, Li et al., 2013, Rogers, 2013.8.12, Japanese National Institute of Genetics, 2012.5.21, Patel et al., 2012, Ja et al., 2009)

Name Synonyms

Mesoderm-invagination signal transducer

(Martin, 2020)

Methuselah-like 1

(Saad and Hipfner, 2021)

Mist

(Ko and Martin, 2020, Paré and Zallen, 2020)

Mth-like 1

(West et al., 2001)

mesoderm-invagination signal transducer

(Manning et al., 2013)

methuselah-like 1

mth-like 1

(Brody and Cravchik, 2000)

Secondary FlyBase IDs

FBgn0046548
FBgn0046549

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (63)