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Gene Dmel\Rrp45

General Information
Symbol	Dmel\Rrp45	Species	D. melanogaster
Name	Rrp45	Annotation symbol	CG9606
Feature type	protein_coding_gene	FlyBase ID	FBgn0030789
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	dRrp45
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	15A8-15A8	Sequence location	X:16,683,486..16,685,266 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rrp45 is referred to in FlyBase by the symbol Dmel\Rrp45 (CG9606, FBgn0030789). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: 3'-5'-exoribonuclease activity. Based on sequence similarity, it is predicted to be involved in the biological process: mRNA processing. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Exoribonuclease, phosphorolytic domain 1; Ribosomal protein S5 domain 2-type fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1626817_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Rrp45. Gene sequence location is X:16683486..16685266.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Mamolen et al., 2010, Nucleic Acids Res. 38(16): 5507--5517 Sequence features HFA20198 BKN21054
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 15A8-15A8   Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rrp45 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rrp45-RA FBtr0074355  NM_132935   1566   412
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rrp45-PA   FBpp0074129   46.3   412   7.33     NP_573163   AAF48665
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Exoribonuclease, phosphorolytic domain 1 (IPR001247) Ribosomal protein S5 domain 2-type fold (IPR020568)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48665   AY089277 AAL90015   BF505501   BG639986   CO295500   CO316690   CO341115   EC204065   EC224486   GH947660   GH949475   GH949714   GH950659   GH951895   GH953340   GH954426   GH957558   GH960413   GH964645   GH976207   GH979604   GH981533
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8T4A9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030789    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030789 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030789 expression level Developmental Stage   Expression Level embryo 00-02hr    2308 embryo 02-04hr    996 embryo 04-06hr    1677 embryo 06-08hr    1739 embryo 08-10hr    1342 embryo 10-12hr    993 embryo 12-14hr    710 embryo 14-16hr    435 embryo 16-18hr    304 embryo 18-20hr    272 embryo 20-22hr    502 embryo 22-24hr    435 larva L1    1375 larva L2    774 larva L3 12hr old    629 larva L3 puffstage 1-2    357 larva L3 puffstage 3-6    517 larva L3 puffstage 7-9    541 white prepupae new    446 white prepupae 12hr    601 white prepupae 24hr    589 pupae 2d postWPP    411 pupae 3d postWPP    215 pupae 4d postWPP    276 adult male 01day    254 adult male 05day    315 adult male 30day    305 adult female 01day    1172 adult female 05day    2121 adult female 30day    2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2308) embryo 02-04hr  (996) embryo 04-06hr  (1677) embryo 06-08hr  (1739) embryo 08-10hr  (1342) embryo 10-12hr  (993) embryo 12-14hr  (710) embryo 14-16hr  (435) embryo 16-18hr  (304) embryo 18-20hr  (272) embryo 20-22hr  (502) embryo 22-24hr  (435) larva L1  (1375) larva L2  (774) larva L3 12hr old  (629) larva L3 puffstage 1-2  (357) larva L3 puffstage 3-6  (517) larva L3 puffstage 7-9  (541) white prepupae new  (446) white prepupae 12hr  (601) white prepupae 24hr  (589) pupae 2d postWPP  (411) pupae 3d postWPP  (215) pupae 4d postWPP  (276) adult male 01day  (254) adult male 05day  (315) adult male 30day  (305) adult female 01day  (1172) adult female 05day  (2121) adult female 30day  (2075) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2308) embryo 02-04hr    996 embryo 04-06hr  (1677) embryo 06-08hr  (1739) embryo 08-10hr    1342 embryo 10-12hr    993 embryo 12-14hr    710 embryo 14-16hr    435 embryo 16-18hr    304 embryo 18-20hr    272 embryo 20-22hr    502 embryo 22-24hr    435 larva L1    1375 larva L2    774 larva L3 12hr old    629 larva L3 puffstage 1-2    357 larva L3 puffstage 3-6    517 larva L3 puffstage 7-9    541 white prepupae new    446 white prepupae 12hr    601 white prepupae 24hr    589 pupae 2d postWPP    411 pupae 3d postWPP    215 pupae 4d postWPP    276 adult male 01day    254 adult male 05day    315 adult male 30day    305 adult female 01day    1172 adult female 05day  (2121) adult female 30day  (2075) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2308 embryo 02-04hr    996 embryo 04-06hr    1677 embryo 06-08hr    1739 embryo 08-10hr    1342 embryo 10-12hr    993 embryo 12-14hr    710 embryo 14-16hr    435 embryo 16-18hr    304 embryo 18-20hr    272 embryo 20-22hr    502 embryo 22-24hr    435 larva L1    1375 larva L2    774 larva L3 12hr old    629 larva L3 puffstage 1-2    357 larva L3 puffstage 3-6    517 larva L3 puffstage 7-9    541 white prepupae new    446 white prepupae 12hr    601 white prepupae 24hr    589 pupae 2d postWPP    411 pupae 3d postWPP    215 pupae 4d postWPP    276 adult male 01day    254 adult male 05day    315 adult male 30day    305 adult female 01day    1172 adult female 05day    2121 adult female 30day    2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2308 embryo 02-04hr    996 embryo 04-06hr    1677 embryo 06-08hr    1739 embryo 08-10hr    1342 embryo 10-12hr    993 embryo 12-14hr    710 embryo 14-16hr    435 embryo 16-18hr    304 embryo 18-20hr    272 embryo 20-22hr    502 embryo 22-24hr    435 larva L1    1375 larva L2    774 larva L3 12hr old    629 larva L3 puffstage 1-2    357 larva L3 puffstage 3-6    517 larva L3 puffstage 7-9    541 white prepupae new    446 white prepupae 12hr    601 white prepupae 24hr    589 pupae 2d postWPP    411 pupae 3d postWPP    215 pupae 4d postWPP    276 adult male 01day    254 adult male 05day    315 adult male 30day    305 adult female 01day    1172 adult female 05day    2121 adult female 30day    2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030789 expression level Developmental Stage   Expression Level embryo 00-02hr    2308 embryo 02-04hr    996 embryo 04-06hr    1677 embryo 06-08hr    1739 embryo 08-10hr    1342 embryo 10-12hr    993 embryo 12-14hr    710 embryo 14-16hr    435 embryo 16-18hr    304 embryo 18-20hr    272 embryo 20-22hr    502 embryo 22-24hr    435 larva L1    1375 larva L2    774 larva L3 12hr old    629 larva L3 puffstage 1-2    357 larva L3 puffstage 3-6    517 larva L3 puffstage 7-9    541 white prepupae new    446 white prepupae 12hr    601 white prepupae 24hr    589 pupae 2d postWPP    411 pupae 3d postWPP    215 pupae 4d postWPP    276 adult male 01day    254 adult male 05day    315 adult male 30day    305 adult female 01day    1172 adult female 05day    2121 adult female 30day    2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2308) embryo 02-04hr  (996) embryo 04-06hr  (1677) embryo 06-08hr  (1739) embryo 08-10hr  (1342) embryo 10-12hr  (993) embryo 12-14hr  (710) embryo 14-16hr  (435) embryo 16-18hr  (304) embryo 18-20hr  (272) embryo 20-22hr  (502) embryo 22-24hr  (435) larva L1  (1375) larva L2  (774) larva L3 12hr old  (629) larva L3 puffstage 1-2  (357) larva L3 puffstage 3-6  (517) larva L3 puffstage 7-9  (541) white prepupae new  (446) white prepupae 12hr  (601) white prepupae 24hr  (589) pupae 2d postWPP  (411) pupae 3d postWPP  (215) pupae 4d postWPP  (276) adult male 01day  (254) adult male 05day  (315) adult male 30day  (305) adult female 01day  (1172) adult female 05day  (2121) adult female 30day  (2075) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2308 embryo 02-04hr    996 embryo 04-06hr  1677 embryo 06-08hr  1739 embryo 08-10hr    1342 embryo 10-12hr    993 embryo 12-14hr    710 embryo 14-16hr    435 embryo 16-18hr    304 embryo 18-20hr    272 embryo 20-22hr    502 embryo 22-24hr    435 larva L1    1375 larva L2    774 larva L3 12hr old    629 larva L3 puffstage 1-2    357 larva L3 puffstage 3-6    517 larva L3 puffstage 7-9    541 white prepupae new    446 white prepupae 12hr    601 white prepupae 24hr    589 pupae 2d postWPP    411 pupae 3d postWPP    215 pupae 4d postWPP    276 adult male 01day    254 adult male 05day    315 adult male 30day    305 adult female 01day    1172 adult female 05day  2121 adult female 30day  2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2308 embryo 02-04hr    996 embryo 04-06hr    1677 embryo 06-08hr    1739 embryo 08-10hr    1342 embryo 10-12hr    993 embryo 12-14hr    710 embryo 14-16hr    435 embryo 16-18hr    304 embryo 18-20hr    272 embryo 20-22hr    502 embryo 22-24hr    435 larva L1    1375 larva L2    774 larva L3 12hr old    629 larva L3 puffstage 1-2    357 larva L3 puffstage 3-6    517 larva L3 puffstage 7-9    541 white prepupae new    446 white prepupae 12hr    601 white prepupae 24hr    589 pupae 2d postWPP    411 pupae 3d postWPP    215 pupae 4d postWPP    276 adult male 01day    254 adult male 05day    315 adult male 30day    305 adult female 01day    1172 adult female 05day    2121 adult female 30day    2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2308 embryo 02-04hr    996 embryo 04-06hr    1677 embryo 06-08hr    1739 embryo 08-10hr    1342 embryo 10-12hr    993 embryo 12-14hr    710 embryo 14-16hr    435 embryo 16-18hr    304 embryo 18-20hr    272 embryo 20-22hr    502 embryo 22-24hr    435 larva L1    1375 larva L2    774 larva L3 12hr old    629 larva L3 puffstage 1-2    357 larva L3 puffstage 3-6    517 larva L3 puffstage 7-9    541 white prepupae new    446 white prepupae 12hr    601 white prepupae 24hr    589 pupae 2d postWPP    411 pupae 3d postWPP    215 pupae 4d postWPP    276 adult male 01day    254 adult male 05day    315 adult male 30day    305 adult female 01day    1172 adult female 05day    2121 adult female 30day    2075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030789    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030789 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030789 expression level Tissue   Expression Level Larval Central Nervous System    103.875 Larval Midgut    35.7 Larval Hindgut    42.7 Larval Malpighian Tubules    34.4 Larval Fat Body no informative data Larval Salivary Gland    57.9 Larval Trachea    84.65 Larval Carcass    52.65 Adult Head    44.5 Adult Eye    27.45 Adult Brain    44.4 Adult Thoracic-Abdominal Ganglion    52 Adult Crop    54.5 Adult Midgut    45.6 Adult Hindgut    34.4 Adult Malpighian Tubules    41.2 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    24.375 Adult VirginFemale Spermatheca    49 Adult InseminatedFemale Spermatheca    66.9 Adult Ovary    202.5 Adult Testis    45 Adult Male Accessory Gland    80.8 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    103.875 Larval Midgut    35.7 Larval Hindgut    42.7 Larval Malpighian Tubules    34.4 Larval Fat Body no informative data Larval Salivary Gland    57.9 Larval Trachea    84.65 Larval Carcass    52.65 Adult Head    44.5 Adult Eye    27.45 Adult Brain    44.4 Adult Thoracic-Abdominal Ganglion    52 Adult Crop    54.5 Adult Midgut    45.6 Adult Hindgut    34.4 Adult Malpighian Tubules    41.2 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    24.375 Adult VirginFemale Spermatheca    49 Adult InseminatedFemale Spermatheca    66.9 Adult Ovary    202.5 Adult Testis    45 Adult Male Accessory Gland    80.8 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    103.875 Larval Midgut    35.7 Larval Hindgut    42.7 Larval Malpighian Tubules    34.4 Larval Fat Body no informative data Larval Salivary Gland    57.9 Larval Trachea    84.65 Larval Carcass    52.65 Adult Head    44.5 Adult Eye    27.45 Adult Brain    44.4 Adult Thoracic-Abdominal Ganglion    52 Adult Crop    54.5 Adult Midgut    45.6 Adult Hindgut    34.4 Adult Malpighian Tubules    41.2 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    24.375 Adult VirginFemale Spermatheca    49 Adult InseminatedFemale Spermatheca    66.9 Adult Ovary    202.5 Adult Testis    45 Adult Male Accessory Gland    80.8 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    103.875 Larval Midgut    35.7 Larval Hindgut    42.7 Larval Malpighian Tubules    34.4 Larval Fat Body no informative data Larval Salivary Gland    57.9 Larval Trachea    84.65 Larval Carcass    52.65 Adult Head    44.5 Adult Eye    27.45 Adult Brain    44.4 Adult Thoracic-Abdominal Ganglion    52 Adult Crop    54.5 Adult Midgut    45.6 Adult Hindgut    34.4 Adult Malpighian Tubules    41.2 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    24.375 Adult VirginFemale Spermatheca    49 Adult InseminatedFemale Spermatheca    66.9 Adult Ovary    202.5 Adult Testis    45 Adult Male Accessory Gland    80.8 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030789 expression level Tissue   Expression Level Larval Central Nervous System    103.875 Larval Midgut    35.7 Larval Hindgut    42.7 Larval Malpighian Tubules    34.4 Larval Fat Body no informative data Larval Salivary Gland    57.9 Larval Trachea    84.65 Larval Carcass    52.65 Adult Head    44.5 Adult Eye    27.45 Adult Brain    44.4 Adult Thoracic-Abdominal Ganglion    52 Adult Crop    54.5 Adult Midgut    45.6 Adult Hindgut    34.4 Adult Malpighian Tubules    41.2 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    24.375 Adult VirginFemale Spermatheca    49 Adult InseminatedFemale Spermatheca    66.9 Adult Ovary    202.5 Adult Testis    45 Adult Male Accessory Gland    80.8 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    103.875 Larval Midgut    35.7 Larval Hindgut    42.7 Larval Malpighian Tubules    34.4 Larval Fat Body no informative data Larval Salivary Gland    57.9 Larval Trachea    84.65 Larval Carcass    52.65 Adult Head    44.5 Adult Eye    27.45 Adult Brain    44.4 Adult Thoracic-Abdominal Ganglion    52 Adult Crop    54.5 Adult Midgut    45.6 Adult Hindgut    34.4 Adult Malpighian Tubules    41.2 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    24.375 Adult VirginFemale Spermatheca    49 Adult InseminatedFemale Spermatheca    66.9 Adult Ovary    202.5 Adult Testis    45 Adult Male Accessory Gland    80.8 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    103.875 Larval Midgut    35.7 Larval Hindgut    42.7 Larval Malpighian Tubules    34.4 Larval Fat Body no informative data Larval Salivary Gland    57.9 Larval Trachea    84.65 Larval Carcass    52.65 Adult Head    44.5 Adult Eye    27.45 Adult Brain    44.4 Adult Thoracic-Abdominal Ganglion    52 Adult Crop    54.5 Adult Midgut    45.6 Adult Hindgut    34.4 Adult Malpighian Tubules    41.2 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    24.375 Adult VirginFemale Spermatheca    49 Adult InseminatedFemale Spermatheca    66.9 Adult Ovary    202.5 Adult Testis    45 Adult Male Accessory Gland    80.8 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    103.875 Larval Midgut    35.7 Larval Hindgut    42.7 Larval Malpighian Tubules    34.4 Larval Fat Body no informative data Larval Salivary Gland    57.9 Larval Trachea    84.65 Larval Carcass    52.65 Adult Head    44.5 Adult Eye    27.45 Adult Brain    44.4 Adult Thoracic-Abdominal Ganglion    52 Adult Crop    54.5 Adult Midgut    45.6 Adult Hindgut    34.4 Adult Malpighian Tubules    41.2 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    24.375 Adult VirginFemale Spermatheca    49 Adult InseminatedFemale Spermatheca    66.9 Adult Ovary    202.5 Adult Testis    45 Adult Male Accessory Gland    80.8 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    44.5   NA  Eye    27.45   NA  Brain    44.4   103.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    52   NA  Crop    54.5   35.7  Midgut    45.6   42.7  Hindgut    34.4   34.4  Malpighian Tubules    41.2   no informative data  Fat Body    42.5   57.9  Salivary Gland    no informative data   NA  Heart    24.375   84.65  Trachea    NA   NA  VirginFemale Spermatheca    49   NA  InseminatedFemale Spermatheca    66.9   NA  Ovary    202.5   NA  Testis    45   NA  Male Accessory Gland    80.8   52.65  Carcass    53.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030789 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9606-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Rrp45 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Rrp45PL43 viable, with Scer\GAL4pnr-MD237 Rrp45GD14268 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Rrp45 Class Mutagen Stocks Known lesion Rrp45PL43 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rrp45 Class Mutagen Stocks Known lesion Rrp45GD14268 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rrp45KK100958 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14268} NA P{KK100958} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Rrp45PL43 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
3'-5'-exoribonuclease activity inferred from sequence or structural similarity with Saccharomyces RRP45 (FlyBase, 1992-)
Biological Process
CV term Evidence References
mRNA processing inferred from sequence or structural similarity with Saccharomyces RRP45 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytoplasmic exosome (RNase complex) inferred from sequence or structural similarity with Saccharomyces RRP45 (FlyBase, 1992-) exosome (RNase complex) inferred from sequence or structural similarity with Saccharomyces RRP40 (Andrulis et al., 2002) nuclear exosome (RNase complex) inferred from sequence or structural similarity with Saccharomyces RRP45 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rrp45 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030789 DroID - A comprehensive database of gene and protein interactions. • FBgn0030789 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32665
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22565 Dere\GG18224 Dgri\GH14641 Dmoj\GI11625 Dper\GL26867 Dpse\GA21908 Dsec\GM13365 Dsim\GD15722 Dvir\GJ11305 Dwil\GK14785 Dyak\GE15642
Curated drosophilid orthologs	Dpse\GA21908
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP002348-PA Anopheles gambiae (mosquito) XP_624243.2 Apis mellifera (honey bee) XP_001947725.1 Acyrthosiphon pisum (pea aphid) At3g60500.1 Arabidopsis thaliana (wall cress) 91577 Batrachochytrium dendrobatidis (chytrid fungus) 261208 Branchiostoma floridae (lancelet) BGIBMGA001131-PA Bombyx mori (silk worm) ENSBTAP00000006502 Bos taurus (bovine) CAL0004911 Candida albicans (a form of yeast) CN23788 Caenorhabditis brenneri (small nematode) CBP18790 Caenorhabditis briggsae (nematode) CE26424 Caenorhabditis elegans (worm) ENSCAFP00000006143 Canis familiaris (dog) CAGL0J00275g Candida glabrata (haploid yeast) Chro.70272 Cryptosporidium hominis (obligate parasite) ENSCINP00000027283 Ciona intestinalis (sea squirt) JA11001 Caenorhabditis japonica (nematode) CMQ035C Cyanidioschyzon merolae (red alga) cn03530 Cryptococcus neoformans (yeast-like fungus) cgd7_2380 Cryptosporidium parvum (protozoan parasite) 114244 Chlamidomonas reinhardtii (green alga) RP26895 Caenorhabditis remanei (nematode) ENSCSAVP00000004808 Ciona savignyi (sedentary tunicate) 176766 Capitella spl (polychaete worm) DDB0202891 Dictyostelium discoideum (amoeba) 40604 Daphnia pulex (daphnia) ENSDARP00000005262 Danio rerio (zebra fish) ENSECAP00000022319 Equus caballus (horse) XP_653189 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000024443 Gymnopilus aculeatus (mushroom) ENSGALP00000019364 Gallus gallus (chicken) 132487 Hypsipyla robusta (cedar shoot borer) ENSP00000368984 Homo sapiens (human) ISCW019641-PA Ixodes scapularis (deer tick) KLLA0C11099g Kluyveromyces lactis (yeast) 172374 Lottia gigantea (owl limpet) LmjF22.1580 Leishmania major (virus) 31214 Monocosta brevicollis (choanoflagellate) ENSMODP00000002363 Monodelphis domestica (gray opossum) ENSMMUP00000012849 Macaca mulatta (rhesus monkey) ENSMUSP00000029269 Mus musculus (house mouse) 106193 Nematostella vectensis (starlet anemone) XP_001607202.1 Nasonia vitripennis (wasp) ENSOANP00000023800 Ornithorynchus anatinus (platypus) ENSORLP00000002480 Oryzias latipes (japanese killifish) LOC_Os02g34570.1 Oryza sativa (asian rice) PF13_0340 Plasmodium falciparum (protozoal parasite) PHUM006056-PA Pediculus humanus (human body louse) PP18099 Pristionchus pacificus (nematode) 232547 Physcomitrella patens (moss) ENSPPYP00000016797 Pongo pygmaeus (orangutan) 137326 Phytophthora sojae (root rot pathogen) 172238 Populus trichocarpa (black cottonwood) ENSPTRP00000028180 Pan troglodytes (chimpanzee) PVX_115185 Plasmodium vivax (protozoal parasite) ENSRNOP00000020662 Rattus norvegicus (norway rat) 144447 Sorghum bicolor (sorghum) YDR280W Saccharomyces cerevisiae (budding yeast) Smp_048620 Schistosoma mansoni (trematode parasite) SPCC757.08 Schizosaccharomyces pombe (fission yeast) XP_788833.2 Strongylocentrotus purpuratus (purple sea urchin) 14906 Trichoplax adhaerens (metazoa) TA19335 Theileria annulata (apicomplexan parasite) XP_974147.1 Tribolium castaneum (red flour beetle) Tc00.1047053506863.50 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511825.260 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000007250 Tetraodon nigroviridis (green spotted pufferfish) TP01_0013 Theileria parva (parasitic protozoan) 21742 Thalassiosira pseudonana (marine diatom) ENSTRUP00000009757 Takifugu rubripes (pufferfish Takifugu) 86621.m00141 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000045663 Xenopus tropicalis (frog) YALI0B08514g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15663 LH10406 ISCW019641 FBgn0233212 FBgn0216790 FBgn0198565 FBgn0187383 FBgn0168296 JGI_V11_40604 FBgn0081893 FBgn0164448 FBgn0134385 FBgn0122117 FBgn0110440 FBgn0099559 BGIBMGA001131 ACYPI010191 GB15723 AGAP002348 PB26074 PHUM006410 GLEAN_07574
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v103549 P{KK100958}VIE-260B v44699 w1118; P{GD14268}v44699
Genomic Clones ( 3 )
	BACR18G21 BACR19G19 BACR33D04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT07738
Other clones	DPiM_AT07738
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	77086 162234 EK210159 EK265644 EP11906 RP004055761 RP004114589 RP004131749 RP004152043 RP004170845 RP004181251 RP004185045 RP004205994 RP004230947 RP004248862 RP004325363 RP004500548 RP004545390 SD09845
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030789 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32665
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Rrp45 CG9606 (Andrulis et al., 2002)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation. (Guertin et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132935 RefSeq (Proteins) • NP_573163 DDBJ / EMBL / GenBank • AAF48665 AAL90015 AY089277 BF505501 Entrez Gene - A searchable database of RefSeq genes. • 32665 UniProtKB/TrEMBL • Q8T4A9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Exoribonuclease, phosphorolytic domain 1 (IPR001247) Ribosomal protein S5 domain 2-type fold (IPR020568)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030789 DroID - A comprehensive database of gene and protein interactions. • FBgn0030789 DRSC - Results from RNAi screens. • FBgn0030789 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030789 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9606-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030789 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32665 InParanoid A subset of ortholog calls from InParanoid. • AGAP002348-PA Anopheles gambiae (mosquito) XP_624243.2 Apis mellifera (honey bee) XP_001947725.1 Acyrthosiphon pisum (pea aphid) At3g60500.1 Arabidopsis thaliana (wall cress) 91577 Batrachochytrium dendrobatidis (chytrid fungus) 261208 Branchiostoma floridae (lancelet) BGIBMGA001131-PA Bombyx mori (silk worm) ENSBTAP00000006502 Bos taurus (bovine) CAL0004911 Candida albicans (a form of yeast) CN23788 Caenorhabditis brenneri (small nematode) CBP18790 Caenorhabditis briggsae (nematode) CE26424 Caenorhabditis elegans (worm) ENSCAFP00000006143 Canis familiaris (dog) CAGL0J00275g Candida glabrata (haploid yeast) Chro.70272 Cryptosporidium hominis (obligate parasite) ENSCINP00000027283 Ciona intestinalis (sea squirt) JA11001 Caenorhabditis japonica (nematode) CMQ035C Cyanidioschyzon merolae (red alga) cn03530 Cryptococcus neoformans (yeast-like fungus) cgd7_2380 Cryptosporidium parvum (protozoan parasite) 114244 Chlamidomonas reinhardtii (green alga) RP26895 Caenorhabditis remanei (nematode) ENSCSAVP00000004808 Ciona savignyi (sedentary tunicate) 176766 Capitella spl (polychaete worm) DDB0202891 Dictyostelium discoideum (amoeba) 40604 Daphnia pulex (daphnia) ENSDARP00000005262 Danio rerio (zebra fish) ENSECAP00000022319 Equus caballus (horse) XP_653189 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000024443 Gymnopilus aculeatus (mushroom) ENSGALP00000019364 Gallus gallus (chicken) 132487 Hypsipyla robusta (cedar shoot borer) ENSP00000368984 Homo sapiens (human) ISCW019641-PA Ixodes scapularis (deer tick) KLLA0C11099g Kluyveromyces lactis (yeast) 172374 Lottia gigantea (owl limpet) LmjF22.1580 Leishmania major (virus) 31214 Monocosta brevicollis (choanoflagellate) ENSMODP00000002363 Monodelphis domestica (gray opossum) ENSMMUP00000012849 Macaca mulatta (rhesus monkey) ENSMUSP00000029269 Mus musculus (house mouse) 106193 Nematostella vectensis (starlet anemone) XP_001607202.1 Nasonia vitripennis (wasp) ENSOANP00000023800 Ornithorynchus anatinus (platypus) ENSORLP00000002480 Oryzias latipes (japanese killifish) LOC_Os02g34570.1 Oryza sativa (asian rice) PF13_0340 Plasmodium falciparum (protozoal parasite) PHUM006056-PA Pediculus humanus (human body louse) PP18099 Pristionchus pacificus (nematode) 232547 Physcomitrella patens (moss) ENSPPYP00000016797 Pongo pygmaeus (orangutan) 137326 Phytophthora sojae (root rot pathogen) 172238 Populus trichocarpa (black cottonwood) ENSPTRP00000028180 Pan troglodytes (chimpanzee) PVX_115185 Plasmodium vivax (protozoal parasite) ENSRNOP00000020662 Rattus norvegicus (norway rat) 144447 Sorghum bicolor (sorghum) YDR280W Saccharomyces cerevisiae (budding yeast) Smp_048620 Schistosoma mansoni (trematode parasite) SPCC757.08 Schizosaccharomyces pombe (fission yeast) XP_788833.2 Strongylocentrotus purpuratus (purple sea urchin) 14906 Trichoplax adhaerens (metazoa) TA19335 Theileria annulata (apicomplexan parasite) XP_974147.1 Tribolium castaneum (red flour beetle) Tc00.1047053506863.50 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511825.260 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000007250 Tetraodon nigroviridis (green spotted pufferfish) TP01_0013 Theileria parva (parasitic protozoan) 21742 Thalassiosira pseudonana (marine diatom) ENSTRUP00000009757 Takifugu rubripes (pufferfish Takifugu) 86621.m00141 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000045663 Xenopus tropicalis (frog) YALI0B08514g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32665 modMine - Data generated by the modENCODE project. • FBgn0030789 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15663 LH10406 ISCW019641 FBgn0233212 FBgn0216790 FBgn0198565 FBgn0187383 FBgn0168296 JGI_V11_40604 FBgn0081893 FBgn0164448 FBgn0134385 FBgn0122117 FBgn0110440 FBgn0099559 BGIBMGA001131 ACYPI010191 GB15723 AGAP002348 PB26074 PHUM006410 GLEAN_07574
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG9606 (Andrulis et al., 2002, Bourbon et al., 2002, Keleman et al., 2009.8.5) dRrp45 (Andrulis et al., 2002, Mamolen et al., 2010) Rrp45 (Guertin et al., 2006) rrp45 (Flynt et al., 2010)
Name Synonym	Rrp45
Secondary FlyBase IDs
References ( 12 )
Research paper	Flynt et al., 2010, Mol. Cell 38(6): 900--907 MicroRNA Biogenesis via Splicing and Exosome-Mediated Trimming in Drosophila. [FBrf0211240] Mamolen et al., 2010, Nucleic Acids Res. 38(16): 5507--5517 Drosophila melanogaster Dis3 N-terminal domains are required for ribonuclease activities, nuclear localization and exosome interactions. [FBrf0211792] Guertin et al., 2006, Curr. Biol. 16(10): 958--970 Functional genomics identifies TOR-regulated genes that control growth and division. [FBrf0192539] Andrulis et al., 2002, Nature 420(6917): 837--841 The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila. [FBrf0155465] Bourbon et al., 2002, Mech. Dev. 110(1-2): 71--83 A P-insertion screen identifying novel X-linked essential genes in Drosophila. [FBrf0141645]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]