FB2021_02, released April 13, 2021

Gene: Dmel\CG9132

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General Information
Symbol
Dmel\CG9132
Species
D. melanogaster
Name
Annotation Symbol
CG9132
Feature Type
protein_coding_gene
FlyBase ID
FBgn0030791
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Summary
May be involved in endocytosis. (UniProt, Q9VXB0)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
15A8-15A9
Sequence location
X:16,796,902..16,800,710 [-]
Recombination map
1-55
RefSeq locus
NC_004354 REGION:16796902..16800710
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (0 terms)
There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2010-12-09 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in endocytosis
inferred from electronic annotation with InterPro:IPR012466
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in vesicle-mediated transport
inferred from biological aspect of ancestor with PANTHER:PTN000303985
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of clathrin vesicle coat
inferred from biological aspect of ancestor with PANTHER:PTN000303985
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the NECAP family. (Q9VXB0)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
May be involved in endocytosis.
(UniProt, Q9VXB0)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\CG9132 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG9132-RA
FBtr0074353
NM_206768
2545
204
CG9132-RB
FBtr0074354
NM_206767
1960
246
CG9132-RC
FBtr0306801
NM_001258791
1792
204
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG9132-PA
FBpp0074127
21.7
204
8.45
NP_996491
AAN09424
CG9132-PB
FBpp0074128
26.6
246
9.28
NP_996490
AAF48667
CG9132-PC
FBpp0297713
21.7
204
8.45
NP_001245720
AFH07433
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

204 aa isoforms: CG9132-PA, CG9132-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Domain

The WXXF motif mediates binding with the GAE domain of proteins.

(UniProt, Q9VXB0)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG9132 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG9132 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG9132
Transgenic constructs containing regulatory region of CG9132
Aberrations (Deficiencies and Duplications) ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
Sterility
Allele
fertile
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NECAP1
13 of 15
Yes
Yes
1  
Hsap\NECAP2
13 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Necap1
14 of 15
Yes
Yes
Mmus\Necap2
11 of 15
No
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Necap1
13 of 13
Yes
Yes
Rnor\Necap2
12 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\necap2
6 of 12
Yes
Yes
Xtro\necap1
2 of 12
No
Yes
Danio rerio (Zebrafish) (2)
Drer\necap1
14 of 15
Yes
Yes
Drer\necap2
12 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ncap-1
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\ABCI18
7 of 9
Yes
Yes
Atha\AT3G58600
6 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CAF16
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190FD5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006353
Drosophila simulans
Dsim\GD15721
Drosophila sechellia
Dsec\GM13364
Drosophila erecta
Dere\GG18223
Drosophila yakuba
Dyak\GE15641
Drosophila ananassae
Dana\GF22665
Drosophila pseudoobscura pseudoobscura
Dpse\GA22643
Drosophila persimilis
Dper\GL26866
Drosophila willistoni
Dwil\GK14774
Drosophila virilis
Dvir\GJ19342
Drosophila mojavensis
Dmoj\GI15152
Drosophila grimshawi
Dgri\GH24888
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509HY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012956
Glossina morsitans
Tsetse fly
Gmor\GMOY010686
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10938
Mayetiola destructor
Hessian fly
Mdes\Mdes009152
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012638
Anopheles darlingi
American malaria mosquito
Adar\ADAC003718
Anopheles gambiae
Malaria mosquito
Agam\AGAP000322
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017447
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0G5G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006932
Danaus plexippus
Monarch butterfly
Dple\DPOGS205101-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015616
Apis florea
Little honeybee
Aflo\4866445716
Apis mellifera
Western honey bee
Amel\LOC409531
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17185
Bombus terrestris
Buff-tailed bumblebee
Bter\15212526
Linepithema humile
Argentine ant
Lhum\LH18704
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0000c0
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005131
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12885
Tribolium castaneum
Red flour beetle
Tcas\TC011619
Pediculus humanus
Human body louse
Phum\PHUM558890
Rhodnius prolixus
Kissing bug
Rpro\RPRC010947
Cimex lectularius
Bed bug
Clec\CLEC009527
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008034
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01391
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0G5X )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014351
Ixodes scapularis
Black-legged tick
Isca\ISCW012864
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61236.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68582.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur28g00850
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_337296
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0PZV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Necap1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024638
Gallus gallus
Domestic chicken
Ggal\NECAP1
Gallus gallus
Domestic chicken
Ggal\NECAP2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NECAP1; NECAP endocytosis associated 1
    13 of 15
    611623
     
    NECAP2; NECAP endocytosis associated 2
    13 of 15
    611624
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-55
        Cytogenetic map
        15A8-15A9
        Sequence location
        X:16,796,902..16,800,710 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        15A8-15A9
        Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        1-55

        (FlyBase, 2016)

        1-56.2

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (5)
        Genomic Clones (13)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (196)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of

          Source for merge of: CG9125 CG9132

          (FlyBase Genome Annotators, 2002-2003)
          Additional comments

          Annotations CG9125 and CG9132 merged as CG32566 in release 3 of the genome annotation.

          (FlyBase Genome Annotators, 2004, FlyBase Genome Annotators, 2002-2003)
          Other Comments
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 39 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (2)
          Reported As
          Symbol Synonym
          CG32566
          CG9132
          (Li-Kroeger et al., 2018, Bischof and FlyORF project members, 2014.6.20, Japanese National Institute of Genetics, 2012.5.21, Keleman et al., 2009.8.5)
          Name Synonyms
          Secondary FlyBase IDs
          • FBgn0052566
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (24)