FlyBase Gene Report: Dmel\ppk28

General Information

Symbol

Dmel\ppk28

Species

D. melanogaster

Name

pickpocket 28

Annotation Symbol

CG4805

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030795

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

pickpocket 28 (ppk28) encodes a member of the degenerin/epithelial Na[+] channel (pickpocket) gene family. It is an osmosensitive ion channel that mediates water taste detection. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

15A9-15A10

Sequence location

X:16,806,068..16,808,515 [+]

Recombination map

1-55

RefSeq locus

NC_004354 REGION:16806068..16808515

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables ligand-gated sodium channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000189658

(GO Reference Genome Project, 2011-)

enables sodium channel activity

inferred from electronic annotation with InterPro:IPR001873

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with MGI:MGI:101782

(Gene Ontology Curators, 2002-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in cellular response to water stimulus

inferred from mutant phenotype

(Cameron et al., 2010)

involved_in drinking behavior

inferred from mutant phenotype

(Cameron et al., 2010)

involved_in liquid clearance, open tracheal system

inferred from mutant phenotype

(Liu et al., 2003)

involved_in response to water

inferred from direct assay

(Chen et al., 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in sodium ion transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000189658

(GO Reference Genome Project, 2011-)

involved_in sodium ion transport

inferred from electronic annotation with InterPro:IPR001873

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with MGI:MGI:101782

(Gene Ontology Curators, 2002-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR001873

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with MGI:MGI:101782

(Gene Ontology Curators, 2002-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000189658

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PICKPOCKET ION CHANNELS

Protein Family (UniProt)

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (Q86LG1)

Protein Signatures (InterPro)

Epithelial sodium channel

Summaries

Gene Snapshot

Gene Group (FlyBase)

PICKPOCKET ION CHANNELS -: The degenerin (DEG)/epithial Na⁺ channel (ENaC) gene family, known as the pickpocket genes in Drosophila, encodes subunits of non-voltage gated, amiloride-sensitive cation channels. Channels may be formed by homo- or heteromeric arrangements of subunits. Each subunit has two transmembrane domains and a large cysteine-rich extracellular loop domain. They are functionally diverse, with roles in fluid and salt absorbance, mechanosensation and chemosensation. (Adapted from FBrf0220901 and FBrf0159284).

Protein Function (UniProtKB)

Osmosensitive ion channel that mediates the cellular and behavioral response to water. Plays an essential role in gustatory water reception. Part of a complex that plays a role in tracheal liquid clearance. Probable role in sodium transport.

(UniProt, Q86LG1)

Summary (Interactive Fly)

amiloride-sensitive Na+ channel - osmosensitive ion channel that mediates response to water - expressed in labellar gustatory chemosensory bristles

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\ppk28 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q86LG1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Supported by strand-specific RNA-Seq data.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

ppk28-RA

FBtr0074335

NM_132941

2190

606

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

ppk28-PA

FBpp0074109

69.2

606

8.48

Q86LG1

NP_573169

AAF48671

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Epithelial sodium channel

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q86LG1

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ppk28 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

ppk28_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.75

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

embryonic/larval tracheal dorsal trunk

(Liu et al., 2003)

embryonic/larval dorsal tracheal branch

(Liu et al., 2003)

tracheal tip cell

(Liu et al., 2003)

embryonic/larval tracheal transverse connective

(Liu et al., 2003)

adult stage

water-sensing neuron of labellar taste bristle

(Cameron et al., 2010)

gustatory receptor neuron | subset of labellar taste bristle

(Cameron et al., 2010)

Additional Descriptive Data

The transcript of ppk28 labels the water-sensing gustatory receptor neurons from the taste bristles of the proboscis. Almost all taste bristles labeled with ScerGAL4^ppk28.PC co-express ppk28 transcript.

(Cameron et al., 2010)

The transcript of ppk28 labels the water-sensing gustatory receptor neurons from the taste bristles of the proboscis. Almost all taste bristles labeled with ScerGAL4^ppk28.PC co-express ppk28.

(Cameron et al., 2010)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{ppk28-GAL4.C}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

water-sensing neuron of labellar taste bristle

(Cameron et al., 2010)

gustatory receptor neuron | subset of labellar taste bristle

(Cameron et al., 2010)

chemosensory neuron of adult labral sensillum 7 | subset

(Joseph et al., 2017)

water-sensing neuron

(Zhang et al., 2020)

Reporter: P{ppk28-GAL4.L}

Stage

Tissue/Position (including subcellular localization)

Reference

second instar larval stage

Kolbchen

(Liu et al., 2003)

Reporter: P{ppk28-LexA.1.004}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

water-sensing neuron

(Kim et al., 2017)

water-sensing neuron of labellar taste bristle

(Li and Montell, 2021)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ppk28 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ppk28

View exonic expression by tissue for Dmel\ppk28

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32671/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030795

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030795

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030795

Flygut - An atlas of the Drosophila adult midgut

FBgn0030795

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ppk28

Transgenic constructs containing regulatory region of ppk28

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 13 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

ppk28^GD3398

viable, with Scer\GAL4^Mef2.PR

ppk28^GD3398

viable, with Scer\GAL4^pnr-MD237

ppk28^GD3398

viable, with Scer\GAL4^tin.CΔ4

ppk28^GD3398

Other Phenotypes

Allele

abnormal memory | adult stage

ppk28^Δ

abnormal neurophysiology

ppk28^Δ

abnormal neurophysiology, with Scer\GAL4^Gr66a.3.153

ppk28^UAS.cCa

abnormal proboscis extension reflex

ppk28^Δ

abnormal proboscis extension reflex, with Scer\GAL4^Gr66a.PD

ppk28^UAS.cCb

abnormal taste perception

ppk28^Δ

abnormal taste perception, with Scer\GAL4^Gr66a.3.153

ppk28^UAS.cCa

Phenotype manifest in

Allele

labellar taste bristle

ppk28^Δ

labellar taste bristle, with Scer\GAL4^Gr66a.3.153

ppk28^UAS.cCa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (9)

Hsap\ASIC1

10 of 14

Yes

Hsap\ASIC2

10 of 14

Yes

Hsap\ASIC3

10 of 14

Yes

Hsap\ASIC4

10 of 14

Yes

Hsap\ASIC5

8 of 14

Yes

Hsap\SCNN1B

7 of 14

Yes

Hsap\SCNN1G

7 of 14

Yes

Hsap\SCNN1A

5 of 14

Hsap\SCNN1D

5 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (8)

Rnor\Asic3

9 of 14

Yes

Rnor\Asic4

9 of 14

Yes

Rnor\Scnn1b

9 of 14

Yes

Rnor\Scnn1g

9 of 14

Yes

Rnor\Asic1

8 of 14

Yes

Rnor\Asic2

8 of 14

Yes

Rnor\Asic5

7 of 14

Rnor\Scnn1a

7 of 14

Yes

Mus musculus (laboratory mouse) (8)

Mmus\Asic1

9 of 14

Yes

Mmus\Asic2

9 of 14

Yes

Mmus\Asic3

9 of 14

Yes

Mmus\Scnn1b

9 of 14

Yes

Mmus\Asic4

8 of 14

Yes

Mmus\Scnn1g

8 of 14

Yes

Mmus\Asic5

7 of 14

Mmus\Scnn1a

6 of 14

Xenopus tropicalis (Western clawed frog) (20)

Xtro\asic4

6 of 13

Yes

Xtro\LOC100497753

6 of 13

Yes

Xtro\scnn1a

5 of 13

Yes

Xtro\scnn1d

5 of 13

Yes

Xtro\LOC101731449

4 of 13

Xtro\LOC116411522

4 of 13

Yes

Xtro\LOC116411523

4 of 13

Yes

Xtro\scnn1b

4 of 13

Xtro\scnn1g

3 of 13

Xtro\trim13

3 of 13

Yes

Xtro\abhd18

1 of 13

Xtro\asic1

1 of 13

Xtro\asic2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\scnn1gl

1 of 13

Yes

Xtro\slc6a3

1 of 13

Xtro\usp45

1 of 13

Danio rerio (Zebrafish) (7)

Drer\asic4a

10 of 14

Yes

Drer\asic4b

10 of 14

Yes

Drer\asic1a

9 of 14

Yes

Drer\asic1c

9 of 14

Yes

Drer\asic1b

8 of 14

Yes

Drer\asic2

8 of 14

Yes

Drer\LOC103910008

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (30)

Cele\acd-1

10 of 14

Yes

Cele\acd-2

10 of 14

Yes

Cele\acd-4

10 of 14

Yes

Cele\delm-1

10 of 14

Yes

Cele\delm-2

10 of 14

Yes

Cele\acd-5

9 of 14

Cele\flr-1

8 of 14

Yes

Cele\asic-2

7 of 14

Yes

Cele\del-1

7 of 14

Yes

Cele\del-4

7 of 14

Yes

Cele\mec-4

7 of 14

Yes

Cele\mec-10

7 of 14

Yes

Cele\asic-1

6 of 14

Cele\deg-1

6 of 14

Yes

Cele\unc-105

6 of 14

Yes

Cele\acd-3

5 of 14

Yes

Cele\unc-8

5 of 14

Yes

Cele\del-10

4 of 14

Cele\del-5

3 of 14

Yes

Cele\del-9

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Cele\degt-1

2 of 14

Yes

Cele\del-6

2 of 14

Yes

Cele\del-7

2 of 14

Yes

Cele\egas-1

2 of 14

Cele\del-8

1 of 14

Yes

Cele\Y57G11C.44

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (24)

Agam\AgaP_AGAP001602

12 of 12

Yes

Agam\AgaP_AGAP011611

6 of 12

Yes

Agam\AgaP_AGAP006703

5 of 12

Yes

Agam\AgaP_AGAP006704

5 of 12

Yes

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:ppk28. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (31)

ppk5

11 of 13

ppk8

11 of 13

ppk12

11 of 13

rpk

11 of 13

ppk26

10 of 13

ppk

10 of 13

9 of 13

8 of 13

7 of 13

7 of 13

6 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 6 )

Human Ortholog

Disease

Evidence

References

SCNN1B; sodium channel epithelial 1 subunit beta

model of bronchiectasis

IEA

(FlyBase, 2019-)

model of bronchiectasis 1

IEA

(FlyBase, 2019-)

model of Liddle syndrome

IEA

(FlyBase, 2019-)

SCNN1G; sodium channel epithelial 1 subunit gamma

model of bronchiectasis

IEA

(FlyBase, 2019-)

model of bronchiectasis 3

IEA

(FlyBase, 2019-)

SCNN1A; sodium channel epithelial 1 subunit alpha

model of bronchiectasis

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ASIC1; acid sensing ion channel subunit 1

10 of 14

602866

ASIC2; acid sensing ion channel subunit 2

10 of 14

601784

ASIC3; acid sensing ion channel subunit 3

10 of 14

611741

ASIC4; acid sensing ion channel subunit family member 4

10 of 14

606715

ASIC5; acid sensing ion channel subunit family member 5

8 of 14

616693

SCNN1B; sodium channel epithelial 1 subunit beta

7 of 14

600760

SCNN1G; sodium channel epithelial 1 subunit gamma

7 of 14

600761

SCNN1A; sodium channel epithelial 1 subunit alpha

5 of 14

600228

SCNN1D; sodium channel epithelial 1 subunit delta

5 of 14

601328

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

ppk28 - AGO2

anti bait coimmunoprecipitation, primer specific pcr

(Taliaferro et al., 2013)

RNA-RNA

Physical Interaction

Assay

References

ppk28 - mir-bft

luminiscence technology, quantitative reverse transcription pcr

(Kim et al., 2017)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

mir-bft

suppressible

ppk28

(Kim et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59002

DroID - A comprehensive database of gene and protein interactions.

FBgn0030795

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Stimuli-sensing channels

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-55

Cytogenetic map

15A9-15A10

Sequence location

X:16,806,068..16,808,515 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

15A9-15A10

Limits computationally determined from genome sequence between P{EP}EP1547^EP1547 and P{EP}CG4928^EP1341

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

15A7-15A7

(Welsh, 2003.1.16)

Experimentally Determined Recombination Data

Location

1-55

(FlyBase, 2016)

1-56.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

33559

w^* P{EP}ppk28^G981

31878

y¹ v¹; P{TRiP.JF02153}attP2

93021

w¹¹¹⁸; P{UAS-ppk28.C}2/CyO; TM2/TM6B

93020

w¹¹¹⁸; Bl¹/CyO; P{ppk28-GAL4.C}3

68038

y¹ sc^* v¹ sev²¹; P{TKO.GS00410}attP40

79385

y¹ sc^* v¹ sev²¹; P{TOE.GS00260}attP40

VDRC

v100946

P{KK106316}VIE-260B

v44412

w¹¹¹⁸; P{GD3398}v44412

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RT06769

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030795

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030795

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

ppk28 is required for water learning but not required for naive water approach in thirsty flies.

(Lin et al., 2014)

Relationship to Other Genes

Source for database merge of

Additional comments

Source for identity of ppk28 CG4805 was sequence comparison ( date:030311 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: ppk28 CG4805

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG4805

(Zelle et al., 2013, Tsubouchi et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Giot et al., 2003, Giannakou and Dow, 2001)

PPK-28

(Sheng et al., 2017)

PPK28

(Scott, 2018, Liu et al., 2003, Welsh, 2003.1.16)

Ppk28

(Engert et al., 2022, Montell, 2021, Guo et al., 2020)

ppk-28

(Jourjine, 2017)

Name Synonyms

pickpocket 28

(Scott, 2018, Waterson et al., 2014, Zelle et al., 2013, Ben-Shahar, 2012.2.9, Tsubouchi et al., 2012, Cameron et al., 2010)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 32 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32671

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q86LG1

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q86LG1

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q86LG1

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32671/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030795

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030795

FlyMine - An integrated database for Drosophila genomics

FBgn0030795

InterPro - A database of protein families, domains and functional sites

Epithelial sodium channel

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4805

MARRVEL_MODEL - MARRVEL (model organism gene)

32671

Linkouts

BioGRID - A database of protein and genetic interactions.

59002

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030795

DroID - A comprehensive database of gene and protein interactions.

FBgn0030795

DRSC - Results frm RNAi screens

FBgn0030795

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

ppk28_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030795

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030795

Flygut - An atlas of the Drosophila adult midgut

FBgn0030795

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0030795

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002095

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Stimuli-sensing channels

References (68)

The following external sites may use different assemblies or annotations than FlyBase.

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