FB2020_06, released Dec 22, 2020

Gene: Dmel\Nprl2

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General Information
Symbol
Dmel\Nprl2
Species
D. melanogaster
Name
Nitrogen permease regulator-like 2
Annotation Symbol
CG9104
Feature Type
protein_coding_gene
FlyBase ID
FBgn0030800
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
Nitrogen permease regulator-like 2 (Nprl2) encodes a component of the highly conserved GAP activity towards rags 1 (GATOR1) complex, which inhibits the product of Tor activity in response to amino acid starvation. The product of Nprl2, as well as the other GATOR1 components encoded by Nprl3 and Iml1, regulates early meiotic progression. [Date last reviewed: 2019-03-14]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
15B4-15B4
Sequence location
X:16,882,509..16,884,365 [-]
Recombination map

1-56

RefSeq locus
NC_004354 REGION:16882509..16884365
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:Nprl3; FB:FBgn0036397
(Wei and Lilly, 2014)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (13 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
involved_in cellular response to amino acid starvation
inferred from mutant phenotype
(assigned by UniProt )
(Bar-Peled et al., 2013)
inferred from mutant phenotype
(Wei and Lilly, 2014)
involved_in germarium-derived egg chamber formation
inferred from genetic interaction with FLYBASE:mio; FB:FBgn0031399
(Wei et al., 2014)
inferred from genetic interaction with FLYBASE:Nup44A; FB:FBgn0033247
(Wei et al., 2014)
involved_in germline cell cycle switching, mitotic to meiotic cell cycle
inferred from genetic interaction with UniProtKB:Q9W0E3
(assigned by UniProt )
(Wei et al., 2014)
involved_in negative regulation of cell size
inferred from mutant phenotype
(Wei and Lilly, 2014)
involved_in negative regulation of macroautophagy by TORC1 signaling
inferred from mutant phenotype
(Wei et al., 2016)
involved_in negative regulation of TOR signaling
inferred from mutant phenotype
(assigned by UniProt )
(Bar-Peled et al., 2013)
involved_in negative regulation of TORC1 signaling
inferred from mutant phenotype
(Wei et al., 2016)
inferred from genetic interaction with FLYBASE:Wdr24; FB:FBgn0027518
(Cai et al., 2016)
involved_in oogenesis
inferred from mutant phenotype
(Wei and Lilly, 2014)
involved_in positive regulation of triglyceride catabolic process
inferred from mutant phenotype
(Wei et al., 2016)
involved_in TORC1 signaling
inferred from mutant phenotype
(Wei and Lilly, 2014)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in cellular response to amino acid starvation
inferred from biological aspect of ancestor with PANTHER:PTN000988255
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in cellular response to nitrogen starvation
inferred from biological aspect of ancestor with PANTHER:PTN000988255
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in negative regulation of TOR signaling
inferred from biological aspect of ancestor with PANTHER:PTN000988255
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in positive regulation of autophagy
inferred from biological aspect of ancestor with PANTHER:PTN000988255
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of autophagosome assembly
inferred from biological aspect of ancestor with PANTHER:PTN000988255
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in autolysosome
inferred from direct assay
(Wei and Lilly, 2014)
located_in cytoplasm
inferred from direct assay
(Wei and Lilly, 2014)
located_in nucleus
inferred from direct assay
(Wei and Lilly, 2014)
part_of Seh1-associated complex
inferred from direct assay
(Cai et al., 2016)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of GATOR1 complex
traceable author statement
(Cai et al., 2016)
inferred from biological aspect of ancestor with PANTHER:PTN000988255
(assigned by GO_Central )
(Gaudet et al., 2011)
part_of Seh1-associated complex
inferred from sequence or structural similarity with SGD:S000000788
(Dokudovskaya et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the NPR2 family. (Q9VXA0)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
GATOR1 COMPLEX -
GATOR1 is a subcomplex of the GATOR (SEA) complex. GATOR1 possesses Rag GTPase activating protein activity and inhibits TORC1 activity in response to amino acid starvation. (Adapted from FBrf0232362 and PMID:25934700).
Protein Function (UniProtKB)
An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823, PubMed:25512509). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:27166823, PubMed:25512509). The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy (PubMed:23723238, PubMed:27166823). In addition, this inhibition of TORC1 is necessary to maintain female fertility under normal conditions and during periods of nutrient stress (PubMed:24786828, PubMed:27672113, PubMed:25512509). GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:25512509). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:25512509).
(UniProt, Q9VXA0)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Nprl2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.44

Gene model reviewed during 5.51

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Nprl2-RA
FBtr0074348
NM_132946
1707
412
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Nprl2-PA
FBpp0074122
46.3
412
8.28
NP_573174
AAF48677
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 (PubMed:27166823). Interacts with Nprl3 (PubMed:24786828).

(UniProt, Q9VXA0)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nprl2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in autolysosome
inferred from direct assay
(Wei and Lilly, 2014)
located_in cytoplasm
inferred from direct assay
(Wei and Lilly, 2014)
located_in nucleus
inferred from direct assay
(Wei and Lilly, 2014)
part_of Seh1-associated complex
inferred from direct assay
(Cai et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Nprl2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Nprl2
Transgenic constructs containing regulatory region of Nprl2
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NPRL2
14 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Nprl2
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Nprl2
13 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\nprl2
9 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\nprl2
14 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\nprl-2
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\NPR2
12 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\npr2
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091908RX )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006365
Drosophila simulans
Dsim\GD15716
Drosophila sechellia
Dsec\GM13358
Drosophila erecta
Dere\GG18217
Drosophila yakuba
Dyak\GE15636
Drosophila ananassae
Dana\GF21822
Drosophila pseudoobscura pseudoobscura
Dpse\GA21545
Drosophila persimilis
Dper\GL22789
Drosophila willistoni
Dwil\GK25826
Drosophila virilis
Dvir\GJ19452
Drosophila mojavensis
Dmoj\GI15348
Drosophila grimshawi
Dgri\GH11927
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504MQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17021643
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL015393
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003870
Anopheles darlingi
American malaria mosquito
Adar\ADAC002847
Anopheles gambiae
Malaria mosquito
Agam\AGAP000438
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019912
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06ZD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003860
Bombyx mori
Silkmoth
Bmor\BGIBMGA009882
Bombyx mori
Silkmoth
Bmor\BGIBMGA003861
Danaus plexippus
Monarch butterfly
Dple\DPOGS200829-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203338-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011469
Heliconius melpomene
Postman butterfly
Hmel\HMEL017934
Apis florea
Little honeybee
Aflo\3317731924
Apis mellifera
Western honey bee
Amel\LOC409317
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25330
Bombus terrestris
Buff-tailed bumblebee
Bter\15207280
Linepithema humile
Argentine ant
Lhum\LH13512
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001003
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005242
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12089
Tribolium castaneum
Red flour beetle
Tcas\TC005889
Pediculus humanus
Human body louse
Phum\PHUM014780
Rhodnius prolixus
Kissing bug
Rpro\RPRC000965
Cimex lectularius
Bed bug
Clec\CLEC009351
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002211
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10112
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06381
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06UP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004867
Ixodes scapularis
Black-legged tick
Isca\ISCW020276
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61099.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur15g02140
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_309307
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_327841
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0759 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tusc4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Zmynd10
Ciona intestinalis
Vase tunicate
Cint\LOC100177840
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000013218
Gallus gallus
Domestic chicken
Ggal\ZMYND10
Gallus gallus
Domestic chicken
Ggal\NPRL2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NPRL2; NPR2 like, GATOR1 complex subunit
    14 of 15
    607072
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Nprl2 - CG4502
      experimental knowledge based
      (Guruharsha et al., 2011)
      Nprl2 - Nprl3
      anti tag coimmunoprecipitation, anti tag western blot
      (Wei and Lilly, 2014)
      Nprl2 - mio
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Cai et al., 2016)
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Nprl2
      suppressible
      Tor
      (Wei et al., 2016)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Iml1
      enhanceable
      Nprl2
      (Wei et al., 2014)
      mio
      suppressible
      Nprl2
      (Wei et al., 2014)
      Nup44A
      suppressible
      Nprl2
      (Wei et al., 2014)
      Wdr24
      suppressible
      Nprl2
      (Cai et al., 2016)
      External Data
      Subunit Structure (UniProtKB)
      Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 (PubMed:27166823). Interacts with Nprl3 (PubMed:24786828).
      (UniProt, Q9VXA0 )
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      X
      Recombination map

      1-56

      Cytogenetic map
      15B4-15B4
      Sequence location
      X:16,882,509..16,884,365 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      15B4-15B4
      Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      1-56

      (FlyBase, 2016)

      1-56.8

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (5)
      Genomic Clones (15)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (8)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: Nprl2 CG9104

        (Wei and Lilly, 2014)
        Source for database merge of
        Additional comments
        Other Comments

        dsRNA has been made from templates generated with primers directed against this gene. RNAi of CG9104 disrupts the dendritic routing patterns of the ddaD and ddaE neurons, resulting in aberrantly oriented primary dendrites. RNAi also causes defects in dendrite morphogenesis.

        (Parrish et al., 2006)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 30 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (8)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (34)