• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Arp8

General Information
Symbol	Dmel\Arp8	Species	D. melanogaster
Name	Actin-related protein 8	Annotation symbol	CG7846
Feature type	protein_coding_gene	FlyBase ID	FBgn0030877
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	16E2-16E2	Sequence location	X:17,752,412..17,754,840 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Actin-related protein 8 is referred to in FlyBase by the symbol Dmel\Arp8 (CG7846, FBgn0030877). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: structural constituent of cytoskeleton. It is reported to be involved in the biological process: cytoskeleton organization. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Actin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1632638_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Arp8. Gene sequence location is X:17752412..17754840.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN28716 HFA20059
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 16E2-16E2   Limits computationally determined from genome sequence between P{EP}EP1464 and P{EP}EP970
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Arp8 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Arp8-RA FBtr0074544  NM_133023   2296   607
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Arp8-PA   FBpp0074318   67.8   607   7.74     NP_573251   AAF48774
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Actin-like (IPR004000)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246831   AA816986   AA820376   AA821004   AA941094   AA949274   AA950786   AE014298 AAF48774   AI455570   AI511790   AI512754   AI516334   AI518512   AI519791   AY051720 AAK93144   BI172696   BI213756   BI216164   BI228997   BI236723   BI361904   BI364150   BI365738   BI366793   BI481867   CO297418   EC213262   EC257200   EV593582   GH750063   GH753342   GH756036   GH760150   GH760191   GH772983   GH775076   GH776614   GH779918   GH779980   GH781192   GH782147   GH782705   GH783514   GH783685   GH785412   GH785776   GH787996   GH789121   GH789670   GH789954   GH789981   GH790103   GH790774   GH795520   GH796785   GH797227   GH798639   GH799286   GH799670   GH800143   GH805817   GH806382   GH809380   GH810158   GH810233   GH811763   GH814857   GH814858   GH815511   GH821378   GH822898   GH823558   GH823642   GH826174   GH827405   GH832251   GH832830   GH835008   GH837018   GH839478   GH840055   GH842829   GH843902   GH846808   GH848876   GH849188   GH852009   GH852675   GH855451   GH855734   GH857493   GH858794   GH865165   GH868767   GH869333   GH870169   GH872256   GH873354   GH874069   GH874350   GH875029   GH875953   GH876212   GH882051   GH882650   GH884009   GH885685   GH890160   GH890518   GH890888   GH891638   GH892601   GH892732   GH892968   GH893053   GH893732   GH894389   GH894456   GH895704   GH896714   GH900169   GH902700   GH903947   GH909431   GH911452   GH912630   GH913589   GH913996   GH914180   GH918070   GH925616   GH927265   GH928190   GH928931   GH931254   GH933262   GH936516   GH937010   GH937787   GH941013
UniProtKB/Swiss-Prot	Q9VX09
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030877    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030877 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030877 expression level Developmental Stage   Expression Level embryo 00-02hr    3845 embryo 02-04hr    3088 embryo 04-06hr    2002 embryo 06-08hr    2516 embryo 08-10hr    2222 embryo 10-12hr    2008 embryo 12-14hr    915 embryo 14-16hr    1155 embryo 16-18hr    686 embryo 18-20hr    408 embryo 20-22hr    449 embryo 22-24hr    422 larva L1    452 larva L2    328 larva L3 12hr old    300 larva L3 puffstage 1-2    293 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    632 white prepupae new    687 white prepupae 12hr    566 white prepupae 24hr    618 pupae 2d postWPP    428 pupae 3d postWPP    176 pupae 4d postWPP    239 adult male 01day    245 adult male 05day    345 adult male 30day    365 adult female 01day    1060 adult female 05day    1635 adult female 30day    1911 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3845) embryo 02-04hr  (3088) embryo 04-06hr  (2002) embryo 06-08hr  (2516) embryo 08-10hr  (2222) embryo 10-12hr  (2008) embryo 12-14hr  (915) embryo 14-16hr  (1155) embryo 16-18hr  (686) embryo 18-20hr  (408) embryo 20-22hr  (449) embryo 22-24hr  (422) larva L1  (452) larva L2  (328) larva L3 12hr old  (300) larva L3 puffstage 1-2  (293) larva L3 puffstage 3-6  (530) larva L3 puffstage 7-9  (632) white prepupae new  (687) white prepupae 12hr  (566) white prepupae 24hr  (618) pupae 2d postWPP  (428) pupae 3d postWPP  (176) pupae 4d postWPP  (239) adult male 01day  (245) adult male 05day  (345) adult male 30day  (365) adult female 01day  (1060) adult female 05day  (1635) adult female 30day  (1911) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3845) embryo 02-04hr  (3088) embryo 04-06hr  (2002) embryo 06-08hr  (2516) embryo 08-10hr  (2222) embryo 10-12hr  (2008) embryo 12-14hr    915 embryo 14-16hr    1155 embryo 16-18hr    686 embryo 18-20hr    408 embryo 20-22hr    449 embryo 22-24hr    422 larva L1    452 larva L2    328 larva L3 12hr old    300 larva L3 puffstage 1-2    293 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    632 white prepupae new    687 white prepupae 12hr    566 white prepupae 24hr    618 pupae 2d postWPP    428 pupae 3d postWPP    176 pupae 4d postWPP    239 adult male 01day    245 adult male 05day    345 adult male 30day    365 adult female 01day    1060 adult female 05day  (1635) adult female 30day  (1911) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3845 embryo 02-04hr    3088 embryo 04-06hr    2002 embryo 06-08hr    2516 embryo 08-10hr    2222 embryo 10-12hr    2008 embryo 12-14hr    915 embryo 14-16hr    1155 embryo 16-18hr    686 embryo 18-20hr    408 embryo 20-22hr    449 embryo 22-24hr    422 larva L1    452 larva L2    328 larva L3 12hr old    300 larva L3 puffstage 1-2    293 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    632 white prepupae new    687 white prepupae 12hr    566 white prepupae 24hr    618 pupae 2d postWPP    428 pupae 3d postWPP    176 pupae 4d postWPP    239 adult male 01day    245 adult male 05day    345 adult male 30day    365 adult female 01day    1060 adult female 05day    1635 adult female 30day    1911 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3845 embryo 02-04hr    3088 embryo 04-06hr    2002 embryo 06-08hr    2516 embryo 08-10hr    2222 embryo 10-12hr    2008 embryo 12-14hr    915 embryo 14-16hr    1155 embryo 16-18hr    686 embryo 18-20hr    408 embryo 20-22hr    449 embryo 22-24hr    422 larva L1    452 larva L2    328 larva L3 12hr old    300 larva L3 puffstage 1-2    293 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    632 white prepupae new    687 white prepupae 12hr    566 white prepupae 24hr    618 pupae 2d postWPP    428 pupae 3d postWPP    176 pupae 4d postWPP    239 adult male 01day    245 adult male 05day    345 adult male 30day    365 adult female 01day    1060 adult female 05day    1635 adult female 30day    1911 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030877 expression level Developmental Stage   Expression Level embryo 00-02hr    3845 embryo 02-04hr    3088 embryo 04-06hr    2002 embryo 06-08hr    2516 embryo 08-10hr    2222 embryo 10-12hr    2008 embryo 12-14hr    915 embryo 14-16hr    1155 embryo 16-18hr    686 embryo 18-20hr    408 embryo 20-22hr    449 embryo 22-24hr    422 larva L1    452 larva L2    328 larva L3 12hr old    300 larva L3 puffstage 1-2    293 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    632 white prepupae new    687 white prepupae 12hr    566 white prepupae 24hr    618 pupae 2d postWPP    428 pupae 3d postWPP    176 pupae 4d postWPP    239 adult male 01day    245 adult male 05day    345 adult male 30day    365 adult female 01day    1060 adult female 05day    1635 adult female 30day    1911 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3845) embryo 02-04hr  (3088) embryo 04-06hr  (2002) embryo 06-08hr  (2516) embryo 08-10hr  (2222) embryo 10-12hr  (2008) embryo 12-14hr  (915) embryo 14-16hr  (1155) embryo 16-18hr  (686) embryo 18-20hr  (408) embryo 20-22hr  (449) embryo 22-24hr  (422) larva L1  (452) larva L2  (328) larva L3 12hr old  (300) larva L3 puffstage 1-2  (293) larva L3 puffstage 3-6  (530) larva L3 puffstage 7-9  (632) white prepupae new  (687) white prepupae 12hr  (566) white prepupae 24hr  (618) pupae 2d postWPP  (428) pupae 3d postWPP  (176) pupae 4d postWPP  (239) adult male 01day  (245) adult male 05day  (345) adult male 30day  (365) adult female 01day  (1060) adult female 05day  (1635) adult female 30day  (1911) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3845) embryo 02-04hr  (3088) embryo 04-06hr  2002 embryo 06-08hr  (2516) embryo 08-10hr  2222 embryo 10-12hr  2008 embryo 12-14hr    915 embryo 14-16hr    1155 embryo 16-18hr    686 embryo 18-20hr    408 embryo 20-22hr    449 embryo 22-24hr    422 larva L1    452 larva L2    328 larva L3 12hr old    300 larva L3 puffstage 1-2    293 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    632 white prepupae new    687 white prepupae 12hr    566 white prepupae 24hr    618 pupae 2d postWPP    428 pupae 3d postWPP    176 pupae 4d postWPP    239 adult male 01day    245 adult male 05day    345 adult male 30day    365 adult female 01day    1060 adult female 05day  1635 adult female 30day  1911 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3845 embryo 02-04hr    3088 embryo 04-06hr    2002 embryo 06-08hr    2516 embryo 08-10hr    2222 embryo 10-12hr    2008 embryo 12-14hr    915 embryo 14-16hr    1155 embryo 16-18hr    686 embryo 18-20hr    408 embryo 20-22hr    449 embryo 22-24hr    422 larva L1    452 larva L2    328 larva L3 12hr old    300 larva L3 puffstage 1-2    293 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    632 white prepupae new    687 white prepupae 12hr    566 white prepupae 24hr    618 pupae 2d postWPP    428 pupae 3d postWPP    176 pupae 4d postWPP    239 adult male 01day    245 adult male 05day    345 adult male 30day    365 adult female 01day    1060 adult female 05day    1635 adult female 30day    1911 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3845 embryo 02-04hr    3088 embryo 04-06hr    2002 embryo 06-08hr    2516 embryo 08-10hr    2222 embryo 10-12hr    2008 embryo 12-14hr    915 embryo 14-16hr    1155 embryo 16-18hr    686 embryo 18-20hr    408 embryo 20-22hr    449 embryo 22-24hr    422 larva L1    452 larva L2    328 larva L3 12hr old    300 larva L3 puffstage 1-2    293 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    632 white prepupae new    687 white prepupae 12hr    566 white prepupae 24hr    618 pupae 2d postWPP    428 pupae 3d postWPP    176 pupae 4d postWPP    239 adult male 01day    245 adult male 05day    345 adult male 30day    365 adult female 01day    1060 adult female 05day    1635 adult female 30day    1911 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030877    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030877 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030877 expression level Tissue   Expression Level Larval Central Nervous System    88.9 Larval Midgut no informative data Larval Hindgut    55 Larval Malpighian Tubules    53.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    84.575 Larval Carcass    71.425 Adult Head    45.1 Adult Eye    49.825 Adult Brain    51.8 Adult Thoracic-Abdominal Ganglion    55.3 Adult Crop    72.5 Adult Midgut no informative data Adult Hindgut    76.9 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    44.65 Adult VirginFemale Spermatheca    63.1 Adult InseminatedFemale Spermatheca    77.7 Adult Ovary    131.1 Adult Testis no informative data Adult Male Accessory Gland    96 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    88.9 Larval Midgut no informative data Larval Hindgut    55 Larval Malpighian Tubules    53.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    84.575 Larval Carcass    71.425 Adult Head    45.1 Adult Eye    49.825 Adult Brain    51.8 Adult Thoracic-Abdominal Ganglion    55.3 Adult Crop    72.5 Adult Midgut no informative data Adult Hindgut    76.9 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    44.65 Adult VirginFemale Spermatheca    63.1 Adult InseminatedFemale Spermatheca    77.7 Adult Ovary    131.1 Adult Testis no informative data Adult Male Accessory Gland    96 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    88.9 Larval Midgut no informative data Larval Hindgut    55 Larval Malpighian Tubules    53.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    84.575 Larval Carcass    71.425 Adult Head    45.1 Adult Eye    49.825 Adult Brain    51.8 Adult Thoracic-Abdominal Ganglion    55.3 Adult Crop    72.5 Adult Midgut no informative data Adult Hindgut    76.9 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    44.65 Adult VirginFemale Spermatheca    63.1 Adult InseminatedFemale Spermatheca    77.7 Adult Ovary    131.1 Adult Testis no informative data Adult Male Accessory Gland    96 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    88.9 Larval Midgut no informative data Larval Hindgut    55 Larval Malpighian Tubules    53.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    84.575 Larval Carcass    71.425 Adult Head    45.1 Adult Eye    49.825 Adult Brain    51.8 Adult Thoracic-Abdominal Ganglion    55.3 Adult Crop    72.5 Adult Midgut no informative data Adult Hindgut    76.9 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    44.65 Adult VirginFemale Spermatheca    63.1 Adult InseminatedFemale Spermatheca    77.7 Adult Ovary    131.1 Adult Testis no informative data Adult Male Accessory Gland    96 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030877 expression level Tissue   Expression Level Larval Central Nervous System    88.9 Larval Midgut no informative data Larval Hindgut    55 Larval Malpighian Tubules    53.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    84.575 Larval Carcass    71.425 Adult Head    45.1 Adult Eye    49.825 Adult Brain    51.8 Adult Thoracic-Abdominal Ganglion    55.3 Adult Crop    72.5 Adult Midgut no informative data Adult Hindgut    76.9 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    44.65 Adult VirginFemale Spermatheca    63.1 Adult InseminatedFemale Spermatheca    77.7 Adult Ovary    131.1 Adult Testis no informative data Adult Male Accessory Gland    96 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    88.9 Larval Midgut no informative data Larval Hindgut    55 Larval Malpighian Tubules    53.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    84.575 Larval Carcass    71.425 Adult Head    45.1 Adult Eye    49.825 Adult Brain    51.8 Adult Thoracic-Abdominal Ganglion    55.3 Adult Crop    72.5 Adult Midgut no informative data Adult Hindgut    76.9 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    44.65 Adult VirginFemale Spermatheca    63.1 Adult InseminatedFemale Spermatheca    77.7 Adult Ovary    131.1 Adult Testis no informative data Adult Male Accessory Gland    96 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    88.9 Larval Midgut no informative data Larval Hindgut    55 Larval Malpighian Tubules    53.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    84.575 Larval Carcass    71.425 Adult Head    45.1 Adult Eye    49.825 Adult Brain    51.8 Adult Thoracic-Abdominal Ganglion    55.3 Adult Crop    72.5 Adult Midgut no informative data Adult Hindgut    76.9 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    44.65 Adult VirginFemale Spermatheca    63.1 Adult InseminatedFemale Spermatheca    77.7 Adult Ovary    131.1 Adult Testis no informative data Adult Male Accessory Gland    96 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    88.9 Larval Midgut no informative data Larval Hindgut    55 Larval Malpighian Tubules    53.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    84.575 Larval Carcass    71.425 Adult Head    45.1 Adult Eye    49.825 Adult Brain    51.8 Adult Thoracic-Abdominal Ganglion    55.3 Adult Crop    72.5 Adult Midgut no informative data Adult Hindgut    76.9 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    44.65 Adult VirginFemale Spermatheca    63.1 Adult InseminatedFemale Spermatheca    77.7 Adult Ovary    131.1 Adult Testis no informative data Adult Male Accessory Gland    96 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    45.1   NA  Eye    49.825   NA  Brain    51.8   88.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    55.3   NA  Crop    72.5   no informative data  Midgut    no informative data   55  Hindgut    76.9   53.6  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    44.65   84.575  Trachea    NA   NA  VirginFemale Spermatheca    63.1   NA  InseminatedFemale Spermatheca    77.7   NA  Ovary    131.1   NA  Testis    no informative data   NA  Male Accessory Gland    96   71.425  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030877 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7846-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Arp8 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Arp8 Class Mutagen Stocks Known lesion Arp8JF01720 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Arp8KK108716 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Arp8GD12302 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12302} NA P{KK108716} NA P{TRiP.JF01720} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
Ino80 complex inferred from direct assay (Klymenko et al., 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
structural constituent of cytoskeleton non-traceable author statement (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15)
Biological Process
CV term Evidence References
cytoskeleton organization non-traceable author statement (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15)
Cellular Component
CV term Evidence References
actin filament non-traceable author statement (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Arp8 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59091 DroID - A comprehensive database of gene and protein interactions. • FBgn0030877 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32769
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21170 Dere\GG18155 Dgri\GH14798 Dmoj\GI16345 Dper\GL14560 Dpse\GA20628 Dsec\GM22847 Dsim\GD15659 Dvir\GJ15683 Dwil\GK25163 Dyak\GE15564
Curated drosophilid orthologs	Dpse\GA20628
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010762-PA Aedes aegypti (mosquito) AGAP010671-PA Anopheles gambiae (mosquito) XP_394752.2 Apis mellifera (honey bee) XP_001946706.1 Acyrthosiphon pisum (pea aphid) At5g43500.1 Arabidopsis thaliana (wall cress) 242188 Branchiostoma floridae (lancelet) BGIBMGA009119-PA Bombyx mori (silk worm) ENSBTAP00000014847 Bos taurus (bovine) CAL0004163 Candida albicans (a form of yeast) ENSCAFP00000012118 Canis familiaris (dog) CAGL0I07161g Candida glabrata (haploid yeast) cn02352 Cryptococcus neoformans (yeast-like fungus) CPIJ004484 Culex pipens (mosquito) ENSCPOP00000006463 Cavia porcellus (guinea pig) 229124 Capitella spl (polychaete worm) DDB0234011 Dictyostelium discoideum (amoeba) DEHA2G10406g Debaryomyces Hansenii (yeast) 301521 Daphnia pulex (daphnia) ENSECAP00000011307 Equus caballus (horse) ENSGACP00000007840 Gymnopilus aculeatus (mushroom) ENSGALP00000008637 Gallus gallus (chicken) 75171 Hypsipyla robusta (cedar shoot borer) ENSP00000336842 Homo sapiens (human) ISCW011057-PA Ixodes scapularis (deer tick) KLLA0E03213g Kluyveromyces lactis (yeast) 134368 Lottia gigantea (owl limpet) 22793 Monocosta brevicollis (choanoflagellate) ENSMODP00000015654 Monodelphis domestica (gray opossum) ENSMMUP00000025320 Macaca mulatta (rhesus monkey) ENSMUSP00000016115 Mus musculus (house mouse) 84908 Nematostella vectensis (starlet anemone) XP_001605850.1 Nasonia vitripennis (wasp) ENSOANP00000012333 Ornithorynchus anatinus (platypus) ENSORLP00000004184 Oryzias latipes (japanese killifish) LOC_Os04g09860.1 Oryza sativa (asian rice) PHUM005246-PA Pediculus humanus (human body louse) 118522 Physcomitrella patens (moss) ENSPPYP00000015423 Pongo pygmaeus (orangutan) 658391 Populus trichocarpa (black cottonwood) ENSPTRP00000025963 Pan troglodytes (chimpanzee) ENSRNOP00000020750 Rattus norvegicus (norway rat) 4760464 Sorghum bicolor (sorghum) YOR141C Saccharomyces cerevisiae (budding yeast) SPAC664.02c Schizosaccharomyces pombe (fission yeast) 53825 Trichoplax adhaerens (metazoa) XP_967032.2 Tribolium castaneum (red flour beetle) ENSTNIP00000014983 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014947 Takifugu rubripes (pufferfish Takifugu) 3810.m01812 Tetrahymena thermophila (ciliate protozoa) YALI0D04719g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16425 NV16894 LH14317 ISCW011057 FBgn0233136 FBgn0227122 FBgn0202871 FBgn0187321 FBgn0177717 JGI_V11_301521 FBgn0080622 FBgn0152165 FBgn0139093 FBgn0122274 FBgn0110371 FBgn0098173 CPIJ004484 BGIBMGA009119 ACYPI002191 GB10541 AGAP010671 ARP8_AEDAE PHUM475090 GLEAN_01452
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	31202 y1 v1; P{TRiP.JF01720}attP2/TM3, Sb1
VDRC	v104425 P{KK108716}VIE-260B
Genomic Clones ( 1 )
	BACR01N10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 137 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24980
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD05821 LD21935 LD23957 LD25052 LD28106 LD30911 LD38052 LD39572 LD42168 LD43313 LD44761 RE15344 RE19249 RE23101 RE26679 RE32830 RE46311 RE49211 RE51111 RE52405 RE64476
Other clones	83534 214513.36 Dmel_neb_008110_0696_1278 EK216928 RP003009674 RP003019668 RP003024354 RP003025932 RP003031107 RP003057148 RP003070508 RP003073542 RP003074181 RP003074262 RP003077899 RP003080344 RP003091324 RP003097382 RP003104024 RP003106911 RP003111960 RP003147328 RP003152109 RP003152133 RP003155406 RP003164064 RP003164421 RP003178829 RP003193706 RP003197400 RP003199246 RP003207143 RP003215476 RP003219259 RP003231676 RP003240449 RP003242118 RP003246162 RP003255552 RP003260621 RP003262056 RP003262281 RP003262997 RP003266995 RP003270027 RP003293263 RP003295371 RP003296703 RP003312418 RP003313345 RP003318213 RP003320573 RP003321695 RP003330811 RP003331743 RP003338262 RP003338916 RP003338942 RP003340380 RP003343119 RP003359065 RP003369347 RP003396592 RP003402290 RP003402982 RP003411572 RP003412747 RP003421817 RP003434419 RP003435545 RP003445188 RP003449156 RP003454239 RP003465527 RP003472037 RP003474745 RP003476362 RP003478699 RP003480345 RP003481142 RP003483177 RP003483345 RP003496413 RP003499329 RP003529316 RP003553860 RP003562431 RP003563725 RP003565180 RP003567599 RP003568023 RP003568745 RP003569290 RP003573826 RP003590287 RP003599234 RP003602059 RP003603609 RP003605703 RP003611726 RP003613719 RP003614982 RP003615506 RP003619238 RP003620165 RP003626436 RP003629064 RP003629725 RP003634817 RP003654010 RP003654018 RP003655438 RP003658188 RP003660196 RP003662323
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030877 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32769
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Arp8 CG7846 (Klymenko et al., 2006)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_133023 RefSeq (Proteins) • NP_573251 DDBJ / EMBL / GenBank • AA821004 AAF48774 AAK93144 AI455570 AY051720 Entrez Gene - A searchable database of RefSeq genes. • 32769 UniProtKB/Swiss-Prot • Q9VX09
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Actin-like (IPR004000)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59091 DroID - A comprehensive database of gene and protein interactions. • FBgn0030877 DRSC - Results from RNAi screens. • FBgn0030877 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030877 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7846-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030877 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32769 InParanoid A subset of ortholog calls from InParanoid. • AAEL010762-PA Aedes aegypti (mosquito) AGAP010671-PA Anopheles gambiae (mosquito) XP_394752.2 Apis mellifera (honey bee) XP_001946706.1 Acyrthosiphon pisum (pea aphid) At5g43500.1 Arabidopsis thaliana (wall cress) 242188 Branchiostoma floridae (lancelet) BGIBMGA009119-PA Bombyx mori (silk worm) ENSBTAP00000014847 Bos taurus (bovine) CAL0004163 Candida albicans (a form of yeast) ENSCAFP00000012118 Canis familiaris (dog) CAGL0I07161g Candida glabrata (haploid yeast) cn02352 Cryptococcus neoformans (yeast-like fungus) CPIJ004484 Culex pipens (mosquito) ENSCPOP00000006463 Cavia porcellus (guinea pig) 229124 Capitella spl (polychaete worm) DDB0234011 Dictyostelium discoideum (amoeba) DEHA2G10406g Debaryomyces Hansenii (yeast) 301521 Daphnia pulex (daphnia) ENSECAP00000011307 Equus caballus (horse) ENSGACP00000007840 Gymnopilus aculeatus (mushroom) ENSGALP00000008637 Gallus gallus (chicken) 75171 Hypsipyla robusta (cedar shoot borer) ENSP00000336842 Homo sapiens (human) ISCW011057-PA Ixodes scapularis (deer tick) KLLA0E03213g Kluyveromyces lactis (yeast) 134368 Lottia gigantea (owl limpet) 22793 Monocosta brevicollis (choanoflagellate) ENSMODP00000015654 Monodelphis domestica (gray opossum) ENSMMUP00000025320 Macaca mulatta (rhesus monkey) ENSMUSP00000016115 Mus musculus (house mouse) 84908 Nematostella vectensis (starlet anemone) XP_001605850.1 Nasonia vitripennis (wasp) ENSOANP00000012333 Ornithorynchus anatinus (platypus) ENSORLP00000004184 Oryzias latipes (japanese killifish) LOC_Os04g09860.1 Oryza sativa (asian rice) PHUM005246-PA Pediculus humanus (human body louse) 118522 Physcomitrella patens (moss) ENSPPYP00000015423 Pongo pygmaeus (orangutan) 658391 Populus trichocarpa (black cottonwood) ENSPTRP00000025963 Pan troglodytes (chimpanzee) ENSRNOP00000020750 Rattus norvegicus (norway rat) 4760464 Sorghum bicolor (sorghum) YOR141C Saccharomyces cerevisiae (budding yeast) SPAC664.02c Schizosaccharomyces pombe (fission yeast) 53825 Trichoplax adhaerens (metazoa) XP_967032.2 Tribolium castaneum (red flour beetle) ENSTNIP00000014983 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014947 Takifugu rubripes (pufferfish Takifugu) 3810.m01812 Tetrahymena thermophila (ciliate protozoa) YALI0D04719g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32769 modMine - Data generated by the modENCODE project. • FBgn0030877 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16425 NV16894 LH14317 ISCW011057 FBgn0233136 FBgn0227122 FBgn0202871 FBgn0187321 FBgn0177717 JGI_V11_301521 FBgn0080622 FBgn0152165 FBgn0139093 FBgn0122274 FBgn0110371 FBgn0098173 CPIJ004484 BGIBMGA009119 ACYPI002191 GB10541 AGAP010671 ARP8_AEDAE PHUM475090 GLEAN_01452
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Arp8   CG7846 (Klymenko et al., 2006, Bakal et al., 2007, Keleman et al., 2009.8.5, Ni et al., 2008) dArp8 (Klymenko et al., 2006)
Name Synonym	Actin-related protein 8   CG7846
Secondary FlyBase IDs
References ( 14 )
Research paper	Ni et al., 2008, Nature Methods 5(1): 49--51 Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. [FBrf0200406] Klymenko et al., 2006, Genes Dev. 20(9): 1110--1122 A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. [FBrf0190547]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Bakal et al., 2007, Science 316(5832): Supporting online material. [FBrf0204776] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Protein sequence record	Swiss-Prot Project Members, 2003.9.15, UniProtKB: Q9VX09 Probable actin-related protein 8. [FBrf0160172]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Zhong, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126703]