FlyBase Gene Report: Dmel\Ada3

• cytoplasm | basal

Comment: apically cleared

(Fisher et al., 2012)

embryonic stage 7 -- 8

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior midgut primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

embryonic central brain neuron

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval nervous system

(Fisher et al., 2012)

third instar larval stage

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

embryonic/larval brain

(Grau et al., 2008)

ventral nerve cord

(Grau et al., 2008)

imaginal disc

(Grau et al., 2008)

embryonic/larval muscle system

(Grau et al., 2008)

embryonic/larval gut

(Grau et al., 2008)

embryonic/larval salivary gland

(Grau et al., 2008)

adult stage | female

follicle cell

(Grau et al., 2008)

nurse cell

(Grau et al., 2008)

adult stage | male

spermatocyte

(Grau et al., 2008)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Grau et al., 2008)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Ada2/Gcn5/Ada3 transcription activator complex

inferred from direct assay

(Suganuma et al., 2012, Guelman et al., 2006)

H3 histone acetyltransferase complex

inferred from direct assay

(Torres-Zelada et al., 2019)

histone acetyltransferase complex

inferred from direct assay

(Guelman et al., 2006)

nucleus

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006, Guelman et al., 2006)

polytene chromosome

inferred from direct assay

(Kusch et al., 2003)

polytene chromosome interband

inferred from direct assay

(Grau et al., 2008)

polytene chromosome puff

inferred from direct assay

(Ciurciu et al., 2009)

SAGA complex

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006)

inferred from physical interaction with FLYBASE:Spt3; FB:FBgn0037981

(Guelman et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ada3 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ada3

View exonic expression by tissue for Dmel\Ada3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030891

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0030891

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7098-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7098

Flygut - An atlas of the Drosophila adult midgut

FBgn0030891

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Ada3

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ada3

Transgenic constructs containing regulatory region of Ada3

Deletions and Duplications ( 1 )

Disrupted in

Df(1)Taf8⁸⁸

(Hernandez-Hernandez and Ferrus, 2001)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal - all die before end of pupal stage

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ada3^GD13421

viable, with Scer\GAL4^Mef2.PR

Ada3^GD13421

viable, with Scer\GAL4^pnr-MD237

Ada3^GD13421

viable, with Scer\GAL4^tin.CΔ4

Ada3^GD13421

Other Phenotypes

Allele

enhancer of variegation, with In(1)sc⁸

Ada3¹

enhancer of variegation, with In(1)w^m4h

Ada3¹

non-enhancer of variegation (with Ada3¹), with In(1)sc⁸

Ada3^+tE4RX

non-enhancer of variegation (with Ada3¹), with In(1)w^m4h

Ada3^+tE4RX

non-enhancer of variegation (with Ada3^+tE4RX), with In(1)sc⁸

Ada3¹

non-enhancer of variegation (with Ada3^+tE4RX), with In(1)w^m4h

Ada3¹

non-enhancer of variegation (with Dp(1;3)JC153), with In(1)sc⁸

Ada3¹

non-enhancer of variegation (with Dp(1;3)JC153), with In(1)w^m4h

Ada3¹

size defective | third instar larval stage

some die during pupal stage

Phenotype manifest in

Allele

germline cell | germline clone

Ada3²

wing disc | third instar larval stage

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\TADA3

14 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Tada3

12 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Tada3

12 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\tada3

9 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\tada3l

13 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

No records found.

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\NGG1

3 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\ngg1

3 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091908EN )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Ada3

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20099

Drosophila persimilis

Dper\GL14943

Drosophila willistoni

Dwil\GK25079

Drosophila virilis

Dvir\GJ16588

Drosophila mojavensis

Dmoj\GI14681

Drosophila grimshawi

Dgri\GH12450

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506O8 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17013529

Glossina morsitans

Tsetse fly

Gmor\GMOY011768

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13787

Mayetiola destructor

Hessian fly

Mdes\Mdes001223

Mayetiola destructor

Hessian fly

Mdes\Mdes005869

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL004675

Anopheles darlingi

American malaria mosquito

Adar\ADAC000288

Anopheles gambiae

Malaria mosquito

Agam\AGAP010459

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ019805

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ018127

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W090F )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA008992

Danaus plexippus

Monarch butterfly

Dple\DPOGS200416-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL017178

Apis florea

Little honeybee

Aflo\4474281860

Apis mellifera

Western honey bee

Amel\LOC411658

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP14406

Bombus terrestris

Buff-tailed bumblebee

Bter\15204325

Linepithema humile

Argentine ant

Lhum\LH23163

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000f93

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG012156

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09222

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09223

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_15353

Pediculus humanus

Human body louse

Phum\PHUM252230

Rhodnius prolixus

Kissing bug

Rpro\RPRC012041

Cimex lectularius

Bed bug

Clec\CLEC000174

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006563

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006055

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_06384

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08W9 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Black-legged tick

Isca\ISCW015632

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78817.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72022.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM62782.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur27g01650

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_309375

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0DWR )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Tada3L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_024183gn

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000008712

Gallus gallus

Domestic chicken

Ggal\TADA3

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TADA3; transcriptional adaptor 3

14 of 15

602945

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ada3 - Ada1-2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Ada3 - Ada2a

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, molecular sieving, two hybrid

(Suganuma et al., 2012, Suganuma et al., 2010, Suganuma et al., 2008, Ciurciu et al., 2006, Guelman et al., 2006, Kusch et al., 2003)

Ada3 - Ada2b

affinity chromatography technology, molecular sieving, multidimensional protein identification technology, two hybrid, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot

(Soffers et al., 2019, Torres-Zelada et al., 2019, Pankotai et al., 2013, Weake et al., 2011, Weake et al., 2009, Ciurciu et al., 2006, Kusch et al., 2003, Muratoglu et al., 2003)

Ada3 - Atac1

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, experimental knowledge based

(Guruharsha et al., 2011, Guelman et al., 2006)

Ada3 - Atac2

experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting, molecular sieving

(Suganuma et al., 2012, Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

Ada3 - Atxn7

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mohan et al., 2014)

Ada3 - Chrac-14

experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting

(Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

Ada3 - D12

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Guruharsha et al., 2011, Suganuma et al., 2010)

Ada3 - Gcn5

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, experimental knowledge based

(Guruharsha et al., 2011, Weake et al., 2009, Guelman et al., 2006)

Ada3 - Hcf

anti bait coimmunoprecipitation, western blot, experimental knowledge based

(Guruharsha et al., 2011, Guelman et al., 2006)

Ada3 - MBD-R2

(Guruharsha et al., 2011)

Ada3 - Mes4

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Guruharsha et al., 2011)

Ada3 - Mocs2B

(Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

Ada3 - Nipped-A

(Kusch et al., 2003)

Ada3 - Rcd1

(Guruharsha et al., 2011)

Ada3 - ReepA

anti tag coimmunoprecipitation, peptide massfingerprinting

(Guruharsha et al., 2011)

Ada3 - Saf6

(Weake et al., 2009)

Ada3 - Sf3b5

anti tag coimmunoprecipitation, peptide massfingerprinting, two hybrid

(Stegeman et al., 2016)

Ada3 - Sgf29

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Guruharsha et al., 2011, Weake et al., 2009)

Ada3 - Spt20

anti tag coimmunoprecipitation, peptide massfingerprinting

(Stegeman et al., 2016)

Ada3 - Spt3

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot

(Stegeman et al., 2016, Guelman et al., 2006, Kusch et al., 2003)

Ada3 - Taf10

(Kusch et al., 2003)

Ada3 - Taf5

(Kusch et al., 2003)

Ada3 - e(y)1