FB2020_01, released Feb 12, 2020

Gene: Dmel\Ada3

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General Information
Symbol
Dmel\Ada3
Species
D. melanogaster
Name
transcriptional Adaptor 3
Annotation Symbol
CG7098
Feature Type
protein_coding_gene
FlyBase ID
FBgn0030891
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Snapshot
transcriptional Adaptor 3 (Ada3) encodes subunit of some chromatin modifying complexes. [Date last reviewed: 2019-08-01]
Other Summaries
Also Known As

dAda3, dik, diskette

Key Links
Genomic Location
Cytogenetic map
16F6-16F6
Sequence location
X:18,085,761..18,088,418 [+]
Recombination map

1-59

RefSeq locus
NC_004354 REGION:18085761..18088418
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
chromatin binding; protein binding
Predictions / Assertions
contributes_to histone acetyltransferase activity; transcription coactivator activity
Summaries
Gene Group (FlyBase)
ATAC COMPLEX -
The Ada2a-containing (ATAC) complex is a metazoan histone acetyltransferase complex. It positively regulates gene transcription and, although it does not have any intrinsic remodeling activity, facilitates nucleosome sliding of ISWI and SWI-SNF families of chromatin-remodeling complexes. (Adapted from FBrf0204126).
SAGA COMPLEX -
The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex is a chromatin modifying complex. SAGA can acetylate and deubiquitinate histone residues. Also SAGA has been shown to regulate the transcriptional activation of a subset of genes. (Adapted from FBrf0228923, FBrf0219841 and FBrf0233349).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Ada3 or the JBrowse view of Dmel\Ada3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Stop-codon suppression (UAG) postulated; FBrf0216884.

Gene model reviewed during 5.44

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ada3-RA
FBtr0074510
NM_078671
2658
556
Ada3-RC
FBtr0339540
NM_001272738
2658
588
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ada3-PA
FBpp0074284
59.9
556
7.48
NP_523395
AAF48794
Ada3-PC
FBpp0308623
63.6
588
8.17
NP_001259667
AGB95509
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ada3 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (23 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
chromatin binding
inferred from direct assay
(Guelman et al., 2006)
protein binding
inferred from physical interaction with UniProtKB:Q8I8V0
(assigned by UniProt )
(Muratoglu et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
contributes_to histone acetyltransferase activity
inferred from biological aspect of ancestor with PANTHER:PTN001005430
(assigned by GO_Central )
(Gaudet et al., 2011)
transcription coactivator activity
inferred from biological aspect of ancestor with PANTHER:PTN001005430
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (11 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
chromatin remodeling
inferred from direct assay
(Suganuma et al., 2008)
chromatin-mediated maintenance of transcription
inferred from mutant phenotype
(Grau et al., 2008)
histone acetylation
inferred from direct assay
(Suganuma et al., 2008)
histone H3 acetylation
inferred from direct assay
(Guelman et al., 2006, Guelman et al., 2006)
histone H3-K14 acetylation
inferred from mutant phenotype
(Grau et al., 2008)
histone H3-K9 acetylation
inferred from mutant phenotype
(Grau et al., 2008)
histone H3-S10 phosphorylation
inferred from mutant phenotype
(Grau et al., 2008)
histone H4 acetylation
inferred from direct assay
(Guelman et al., 2006)
histone H4-K12 acetylation
inferred from mutant phenotype
(Grau et al., 2008)
positive regulation of histone acetylation
inferred from direct assay
(Grau et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
histone H3 acetylation
inferred from biological aspect of ancestor with PANTHER:PTN001005430
(assigned by GO_Central )
(Gaudet et al., 2011)
histone H4 acetylation
inferred from biological aspect of ancestor with PANTHER:PTN001005430
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001005430
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (8 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
Ada2/Gcn5/Ada3 transcription activator complex
inferred from direct assay
(Suganuma et al., 2012, Guelman et al., 2006)
H3 histone acetyltransferase complex
inferred from direct assay
(Torres-Zelada et al., 2019)
histone acetyltransferase complex
inferred from direct assay
(Guelman et al., 2006)
nucleus
inferred from direct assay
(Weake et al., 2011, Guelman et al., 2006, Guelman et al., 2006)
polytene chromosome
inferred from direct assay
(Kusch et al., 2003)
polytene chromosome interband
inferred from direct assay
(Grau et al., 2008)
polytene chromosome puff
inferred from direct assay
(Ciurciu et al., 2009)
SAGA complex
inferred from direct assay
(Weake et al., 2011, Guelman et al., 2006)
inferred from physical interaction with FLYBASE:Spt3; FB:FBgn0037981
(Guelman et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Ada2/Gcn5/Ada3 transcription activator complex
inferred from biological aspect of ancestor with PANTHER:PTN001005430
(assigned by GO_Central )
(Gaudet et al., 2011)
SAGA complex
inferred from biological aspect of ancestor with PANTHER:PTN001005430
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous

Comment: apically cleared

(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
third instar larval stage
embryonic/larval brain
(Grau et al., 2008)
ventral nerve cord
(Grau et al., 2008)
imaginal disc
(Grau et al., 2008)
embryonic/larval muscle system
(Grau et al., 2008)
embryonic/larval gut
(Grau et al., 2008)
embryonic/larval salivary gland
(Grau et al., 2008)
adult stage | female
follicle cell
(Grau et al., 2008)
nurse cell
(Grau et al., 2008)
adult stage | male
spermatocyte
(Grau et al., 2008)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Grau et al., 2008)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Ada2/Gcn5/Ada3 transcription activator complex
inferred from direct assay
(Suganuma et al., 2012, Guelman et al., 2006)
H3 histone acetyltransferase complex
inferred from direct assay
(Torres-Zelada et al., 2019)
histone acetyltransferase complex
inferred from direct assay
(Guelman et al., 2006)
nucleus
inferred from direct assay
(Weake et al., 2011, Guelman et al., 2006, Guelman et al., 2006)
polytene chromosome
inferred from direct assay
(Kusch et al., 2003)
polytene chromosome interband
inferred from direct assay
(Grau et al., 2008)
polytene chromosome puff
inferred from direct assay
(Ciurciu et al., 2009)
SAGA complex
inferred from direct assay
(Weake et al., 2011, Guelman et al., 2006)
inferred from physical interaction with FLYBASE:Spt3; FB:FBgn0037981
(Guelman et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ada3 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ada3
Transgenic constructs containing regulatory region of Ada3
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TADA3
14 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tada3
12 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Tada3
12 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\tada3
9 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\tada3l
13 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\NGG1
3 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\ngg1
3 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091908EN )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Ada3
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005354
Drosophila simulans
Dsim\GD27178
Drosophila sechellia
Dsec\GM22876
Drosophila erecta
Dere\GG19146
Drosophila yakuba
Dyak\GE17706
Drosophila ananassae
Dana\GF19367
Drosophila pseudoobscura pseudoobscura
Dpse\GA20099
Drosophila persimilis
Dper\GL14943
Drosophila willistoni
Dwil\GK25079
Drosophila virilis
Dvir\GJ16588
Drosophila mojavensis
Dmoj\GI14681
Drosophila grimshawi
Dgri\GH12450
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506O8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17013529
Glossina morsitans
Tsetse fly
Gmor\GMOY011768
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13787
Mayetiola destructor
Hessian fly
Mdes\Mdes001223
Mayetiola destructor
Hessian fly
Mdes\Mdes005869
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004675
Anopheles darlingi
American malaria mosquito
Adar\ADAC000288
Anopheles gambiae
Malaria mosquito
Agam\AGAP010459
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019805
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018127
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W090F )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008992
Danaus plexippus
Monarch butterfly
Dple\DPOGS200416-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017178
Apis florea
Little honeybee
Aflo\4474281860
Apis mellifera
Western honey bee
Amel\LOC411658
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14406
Bombus terrestris
Buff-tailed bumblebee
Bter\15204325
Linepithema humile
Argentine ant
Lhum\LH23163
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000f93
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012156
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09222
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09223
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15353
Pediculus humanus
Human body louse
Phum\PHUM252230
Rhodnius prolixus
Kissing bug
Rpro\RPRC012041
Cimex lectularius
Bed bug
Clec\CLEC000174
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006563
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006055
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06384
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08W9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW015632
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78817.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72022.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62782.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur27g01650
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_309375
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0DWR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tada3L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_024183gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008712
Gallus gallus
Domestic chicken
Ggal\TADA3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TADA3; transcriptional adaptor 3
    14 of 15
    602945
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Ada3 - Ada1-2
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Weake et al., 2009)
        Ada3 - Ada2a
        anti tag coimmunoprecipitation, western blot, molecular sieving, peptide massfingerprinting, two hybrid, anti bait coimmunoprecipitation
        (Suganuma et al., 2012, Suganuma et al., 2010, Suganuma et al., 2008, Ciurciu et al., 2006, Guelman et al., 2006, Kusch et al., 2003)
        Ada3 - Ada2b
        anti tag coimmunoprecipitation, peptide massfingerprinting, affinity chromatography technology, molecular sieving, multidimensional protein identification technology, anti bait coimmunoprecipitation, western blot, two hybrid, anti tag western blot
        (Soffers et al., 2019, Torres-Zelada et al., 2019, Pankotai et al., 2013, Weake et al., 2011, Weake et al., 2009, Ciurciu et al., 2006, Kusch et al., 2003, Muratoglu et al., 2003)
        Ada3 - Atac1
        anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, experimental knowledge based
        (Guruharsha et al., 2011, Guelman et al., 2006)
        Ada3 - Atac2
        experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting, molecular sieving
        (Suganuma et al., 2012, Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)
        Ada3 - Atxn7
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Mohan et al., 2014)
        Ada3 - Chrac-14
        experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
        (Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)
        Ada3 - D12
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Guruharsha et al., 2011, Suganuma et al., 2010)
        Ada3 - Gcn5
        anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Guruharsha et al., 2011, Weake et al., 2009, Guelman et al., 2006)
        Ada3 - Hcf
        anti bait coimmunoprecipitation, western blot, experimental knowledge based
        (Guruharsha et al., 2011, Guelman et al., 2006)
        Ada3 - MBD-R2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Ada3 - Mes4
        experimental knowledge based
        (Guruharsha et al., 2011)
        Ada3 - Mocs2B
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)
        Ada3 - Nipped-A
        anti bait coimmunoprecipitation, western blot
        (Kusch et al., 2003)
        Ada3 - Rcd1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Ada3 - ReepA
        experimental knowledge based
        (Guruharsha et al., 2011)
        Ada3 - Saf6
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Weake et al., 2009)
        Ada3 - Sf3b5
        two hybrid, anti tag coimmunoprecipitation, peptide massfingerprinting
        (Stegeman et al., 2016)
        Ada3 - Sgf29
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Guruharsha et al., 2011, Weake et al., 2009)
        Ada3 - Spt20
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Stegeman et al., 2016)
        Ada3 - Spt3
        anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
        (Stegeman et al., 2016, Guelman et al., 2006, Kusch et al., 2003)
        Ada3 - Taf10
        anti bait coimmunoprecipitation, western blot
        (Kusch et al., 2003)
        Ada3 - Taf5
        anti bait coimmunoprecipitation, western blot
        (Kusch et al., 2003)
        Ada3 - e(y)1
        anti bait coimmunoprecipitation, western blot
        (Kusch et al., 2003)
        Ada3 - wda
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Weake et al., 2009)
        Ada3 - wds
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Suganuma et al., 2010, Suganuma et al., 2008)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Ada3
        suppressible
        ara
        (Grau et al., 2008)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map

        1-59

        Cytogenetic map
        16F6-16F6
        Sequence location
        X:18,085,761..18,088,418 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        16F6-16F6
        Limits computationally determined from genome sequence between P{EP}EP970 and P{EP}ari-1EP317
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        16F-16F
        (Aguilera, 2000.4.24, Aguilera et al., 1999)
        Experimentally Determined Recombination Data
        Location

        1-59

        (FlyBase, 2016)

        1-58.9

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (4)
        Genomic Clones (11)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (220)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Grau et al., 2008, Kusch et al., 2003)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: dik CG7098

          (FlyBase, 1996-)

          Source for identity of: Ada3 dik

          (Grau et al., 2008)
          Source for database merge of

          Source for merge of: dik Ada3

          (FlyBase, 1996-)
          Additional comments

          Source for merge of dik Ada3 was sequence comparison ( date:030604 ).

          (FlyBase, 1996-)

          Source for identity of dik CG7098 was sequence comparison ( date:000501 ).

          (FlyBase, 1996-)
          Other Comments
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 37 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (10)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (57)