Frq, frequenin, HL-II
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Frq1 using the Feature Mapper tool.
Frq protein is detected at low levels in embryos, third instar larvae, and pupae, and at high levels in adults on Western blots. Immunolocalization shows that Frq protein is localized mainly to the nervous system. In late embryos, it is expressed in distinct groups of cells in the CNS and in some neurons of the PNS. In larvae and adults, it is detected mainly in synaptic regions, especially in adult brain and in larval and adult neuromuscular junctions. Staining is particularly intense in the synapses of motor nerves innervating larval or adult muscle. At higher magnification, staining is also seen in the adult brain in neuropil areas and in some cells (probably glia) in the lamina.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Frq1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Frq1 encodes a novel Ca2+ binding protein, in vitro Ca2+ binds to both the third and fourth EF-hands. Frq1 is expressed in the central and peripheral nervous system of embryos, larvae and adults, and is particularly enriched at the synapses. Overexpression of Frq1 at the neuromuscular junction causes enhanced frequency-dependent facilitation of neurotransmitter release.