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Gene Dmel\Him

General Information
Symbol	Dmel\Him	Species	D. melanogaster
Name	Holes in muscle	Annotation symbol	CG15064
Feature type	protein_coding_gene	FlyBase ID	FBgn0030900
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	17A2-17A2	Sequence location	X:18,103,464..18,104,774 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Holes in muscle is referred to in FlyBase by the symbol Dmel\Him (CG15064, FBgn0030900). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: negative regulation of muscle organ development. 6 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; embryonic/larval muscle system. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1628247_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Him. Gene sequence location is X:18103464..18104774.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References Cunha et al., 2010, PLoS Genet. 6: e1001014 Sequence features BKN31297 HFA19638
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 17A2-17A2   Limits computationally determined from genome sequence between P{EP}ari-1EP317 and P{EP}EP1378
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Him for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Him-RA FBtr0074549  NM_133045   916   192
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Him-PA   FBpp0074321   23.1   192   9.26     NP_573273   AAF48811
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48811   AY070599 AAL48070   BI486590
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VWX6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030900    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030900 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030900 expression level Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    466 embryo 04-06hr    2418 embryo 06-08hr    5297 embryo 08-10hr    5357 embryo 10-12hr    3929 embryo 12-14hr    2308 embryo 14-16hr    788 embryo 16-18hr    185 embryo 18-20hr    157 embryo 20-22hr    82 embryo 22-24hr    123 larva L1    20 larva L2    20 larva L3 12hr old    12 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    134 larva L3 puffstage 7-9    196 white prepupae new    291 white prepupae 12hr    1245 white prepupae 24hr    1501 pupae 2d postWPP    324 pupae 3d postWPP    75 pupae 4d postWPP    172 adult male 01day    97 adult male 05day    130 adult male 30day    114 adult female 01day    23 adult female 05day    6 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr  (466) embryo 04-06hr  (2418) embryo 06-08hr  (5297) embryo 08-10hr  (5357) embryo 10-12hr  (3929) embryo 12-14hr  (2308) embryo 14-16hr  (788) embryo 16-18hr  (185) embryo 18-20hr  (157) embryo 20-22hr    82 embryo 22-24hr  (123) larva L1    20 larva L2    20 larva L3 12hr old    12 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6  (134) larva L3 puffstage 7-9  (196) white prepupae new  (291) white prepupae 12hr  (1245) white prepupae 24hr  (1501) pupae 2d postWPP  (324) pupae 3d postWPP    75 pupae 4d postWPP  (172) adult male 01day    97 adult male 05day  (130) adult male 30day  (114) adult female 01day    23 adult female 05day    6 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    466 embryo 04-06hr  (2418) embryo 06-08hr  (5297) embryo 08-10hr  (5357) embryo 10-12hr  (3929) embryo 12-14hr  (2308) embryo 14-16hr    788 embryo 16-18hr    185 embryo 18-20hr    157 embryo 20-22hr    82 embryo 22-24hr    123 larva L1    20 larva L2    20 larva L3 12hr old    12 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    134 larva L3 puffstage 7-9    196 white prepupae new    291 white prepupae 12hr    1245 white prepupae 24hr  1501 pupae 2d postWPP    324 pupae 3d postWPP    75 pupae 4d postWPP    172 adult male 01day    97 adult male 05day    130 adult male 30day    114 adult female 01day    23 adult female 05day    6 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    466 embryo 04-06hr    2418 embryo 06-08hr    5297 embryo 08-10hr    5357 embryo 10-12hr    3929 embryo 12-14hr    2308 embryo 14-16hr    788 embryo 16-18hr    185 embryo 18-20hr    157 embryo 20-22hr    82 embryo 22-24hr    123 larva L1    20 larva L2    20 larva L3 12hr old    12 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    134 larva L3 puffstage 7-9    196 white prepupae new    291 white prepupae 12hr    1245 white prepupae 24hr    1501 pupae 2d postWPP    324 pupae 3d postWPP    75 pupae 4d postWPP    172 adult male 01day    97 adult male 05day    130 adult male 30day    114 adult female 01day    23 adult female 05day    6 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    466 embryo 04-06hr    2418 embryo 06-08hr    5297 embryo 08-10hr    5357 embryo 10-12hr    3929 embryo 12-14hr    2308 embryo 14-16hr    788 embryo 16-18hr    185 embryo 18-20hr    157 embryo 20-22hr    82 embryo 22-24hr    123 larva L1    20 larva L2    20 larva L3 12hr old    12 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    134 larva L3 puffstage 7-9    196 white prepupae new    291 white prepupae 12hr    1245 white prepupae 24hr    1501 pupae 2d postWPP    324 pupae 3d postWPP    75 pupae 4d postWPP    172 adult male 01day    97 adult male 05day    130 adult male 30day    114 adult female 01day    23 adult female 05day    6 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030900 expression level Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    466 embryo 04-06hr    2418 embryo 06-08hr    5297 embryo 08-10hr    5357 embryo 10-12hr    3929 embryo 12-14hr    2308 embryo 14-16hr    788 embryo 16-18hr    185 embryo 18-20hr    157 embryo 20-22hr    82 embryo 22-24hr    123 larva L1    20 larva L2    20 larva L3 12hr old    12 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    134 larva L3 puffstage 7-9    196 white prepupae new    291 white prepupae 12hr    1245 white prepupae 24hr    1501 pupae 2d postWPP    324 pupae 3d postWPP    75 pupae 4d postWPP    172 adult male 01day    97 adult male 05day    130 adult male 30day    114 adult female 01day    23 adult female 05day    6 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr  (466) embryo 04-06hr  (2418) embryo 06-08hr  (5297) embryo 08-10hr  (5357) embryo 10-12hr  (3929) embryo 12-14hr  (2308) embryo 14-16hr  (788) embryo 16-18hr  (185) embryo 18-20hr  (157) embryo 20-22hr    82 embryo 22-24hr  123 larva L1    20 larva L2    20 larva L3 12hr old    12 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6  134 larva L3 puffstage 7-9  (196) white prepupae new  (291) white prepupae 12hr  (1245) white prepupae 24hr  (1501) pupae 2d postWPP  (324) pupae 3d postWPP    75 pupae 4d postWPP  (172) adult male 01day    97 adult male 05day  130 adult male 30day  114 adult female 01day    23 adult female 05day    6 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    466 embryo 04-06hr  2418 embryo 06-08hr  (5297) embryo 08-10hr  (5357) embryo 10-12hr  (3929) embryo 12-14hr  2308 embryo 14-16hr    788 embryo 16-18hr    185 embryo 18-20hr    157 embryo 20-22hr    82 embryo 22-24hr    123 larva L1    20 larva L2    20 larva L3 12hr old    12 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    134 larva L3 puffstage 7-9    196 white prepupae new    291 white prepupae 12hr    1245 white prepupae 24hr  1501 pupae 2d postWPP    324 pupae 3d postWPP    75 pupae 4d postWPP    172 adult male 01day    97 adult male 05day    130 adult male 30day    114 adult female 01day    23 adult female 05day    6 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    466 embryo 04-06hr    2418 embryo 06-08hr    5297 embryo 08-10hr    5357 embryo 10-12hr    3929 embryo 12-14hr    2308 embryo 14-16hr    788 embryo 16-18hr    185 embryo 18-20hr    157 embryo 20-22hr    82 embryo 22-24hr    123 larva L1    20 larva L2    20 larva L3 12hr old    12 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    134 larva L3 puffstage 7-9    196 white prepupae new    291 white prepupae 12hr    1245 white prepupae 24hr    1501 pupae 2d postWPP    324 pupae 3d postWPP    75 pupae 4d postWPP    172 adult male 01day    97 adult male 05day    130 adult male 30day    114 adult female 01day    23 adult female 05day    6 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    466 embryo 04-06hr    2418 embryo 06-08hr    5297 embryo 08-10hr    5357 embryo 10-12hr    3929 embryo 12-14hr    2308 embryo 14-16hr    788 embryo 16-18hr    185 embryo 18-20hr    157 embryo 20-22hr    82 embryo 22-24hr    123 larva L1    20 larva L2    20 larva L3 12hr old    12 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    134 larva L3 puffstage 7-9    196 white prepupae new    291 white prepupae 12hr    1245 white prepupae 24hr    1501 pupae 2d postWPP    324 pupae 3d postWPP    75 pupae 4d postWPP    172 adult male 01day    97 adult male 05day    130 adult male 30day    114 adult female 01day    23 adult female 05day    6 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030900    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030900 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030900 expression level Tissue   Expression Level Larval Central Nervous System    0.55 Larval Midgut    4.8 Larval Hindgut    1.3 Larval Malpighian Tubules    2.2 Larval Fat Body    9.1 Larval Salivary Gland    1.7 Larval Trachea    4.35 Larval Carcass    2.575 Adult Head    2.2 Adult Eye    3.175 Adult Brain    1.5 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    4.5 Adult Midgut    3.3 Adult Hindgut    1.2 Adult Malpighian Tubules    2.8 Adult Fat Body    2.8 Adult Salivary Gland    6.8 Adult Heart    3.1 Adult VirginFemale Spermatheca    3.5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    1.3 Adult Testis no informative data Adult Male Accessory Gland    6 Adult Carcass    8.8 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.55 Larval Midgut    4.8 Larval Hindgut    1.3 Larval Malpighian Tubules    2.2 Larval Fat Body    9.1 Larval Salivary Gland    1.7 Larval Trachea    4.35 Larval Carcass    2.575 Adult Head    2.2 Adult Eye    3.175 Adult Brain    1.5 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    4.5 Adult Midgut    3.3 Adult Hindgut    1.2 Adult Malpighian Tubules    2.8 Adult Fat Body    2.8 Adult Salivary Gland    6.8 Adult Heart    3.1 Adult VirginFemale Spermatheca    3.5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    1.3 Adult Testis no informative data Adult Male Accessory Gland    6 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.55 Larval Midgut    4.8 Larval Hindgut    1.3 Larval Malpighian Tubules    2.2 Larval Fat Body    9.1 Larval Salivary Gland    1.7 Larval Trachea    4.35 Larval Carcass    2.575 Adult Head    2.2 Adult Eye    3.175 Adult Brain    1.5 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    4.5 Adult Midgut    3.3 Adult Hindgut    1.2 Adult Malpighian Tubules    2.8 Adult Fat Body    2.8 Adult Salivary Gland    6.8 Adult Heart    3.1 Adult VirginFemale Spermatheca    3.5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    1.3 Adult Testis no informative data Adult Male Accessory Gland    6 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.55 Larval Midgut    4.8 Larval Hindgut    1.3 Larval Malpighian Tubules    2.2 Larval Fat Body    9.1 Larval Salivary Gland    1.7 Larval Trachea    4.35 Larval Carcass    2.575 Adult Head    2.2 Adult Eye    3.175 Adult Brain    1.5 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    4.5 Adult Midgut    3.3 Adult Hindgut    1.2 Adult Malpighian Tubules    2.8 Adult Fat Body    2.8 Adult Salivary Gland    6.8 Adult Heart    3.1 Adult VirginFemale Spermatheca    3.5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    1.3 Adult Testis no informative data Adult Male Accessory Gland    6 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030900 expression level Tissue   Expression Level Larval Central Nervous System    0.55 Larval Midgut    4.8 Larval Hindgut    1.3 Larval Malpighian Tubules    2.2 Larval Fat Body    9.1 Larval Salivary Gland    1.7 Larval Trachea    4.35 Larval Carcass    2.575 Adult Head    2.2 Adult Eye    3.175 Adult Brain    1.5 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    4.5 Adult Midgut    3.3 Adult Hindgut    1.2 Adult Malpighian Tubules    2.8 Adult Fat Body    2.8 Adult Salivary Gland    6.8 Adult Heart    3.1 Adult VirginFemale Spermatheca    3.5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    1.3 Adult Testis no informative data Adult Male Accessory Gland    6 Adult Carcass    8.8 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.55 Larval Midgut    4.8 Larval Hindgut    1.3 Larval Malpighian Tubules    2.2 Larval Fat Body    9.1 Larval Salivary Gland    1.7 Larval Trachea    4.35 Larval Carcass    2.575 Adult Head    2.2 Adult Eye    3.175 Adult Brain    1.5 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    4.5 Adult Midgut    3.3 Adult Hindgut    1.2 Adult Malpighian Tubules    2.8 Adult Fat Body    2.8 Adult Salivary Gland    6.8 Adult Heart    3.1 Adult VirginFemale Spermatheca    3.5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    1.3 Adult Testis no informative data Adult Male Accessory Gland    6 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.55 Larval Midgut    4.8 Larval Hindgut    1.3 Larval Malpighian Tubules    2.2 Larval Fat Body    9.1 Larval Salivary Gland    1.7 Larval Trachea    4.35 Larval Carcass    2.575 Adult Head    2.2 Adult Eye    3.175 Adult Brain    1.5 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    4.5 Adult Midgut    3.3 Adult Hindgut    1.2 Adult Malpighian Tubules    2.8 Adult Fat Body    2.8 Adult Salivary Gland    6.8 Adult Heart    3.1 Adult VirginFemale Spermatheca    3.5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    1.3 Adult Testis no informative data Adult Male Accessory Gland    6 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.55 Larval Midgut    4.8 Larval Hindgut    1.3 Larval Malpighian Tubules    2.2 Larval Fat Body    9.1 Larval Salivary Gland    1.7 Larval Trachea    4.35 Larval Carcass    2.575 Adult Head    2.2 Adult Eye    3.175 Adult Brain    1.5 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    4.5 Adult Midgut    3.3 Adult Hindgut    1.2 Adult Malpighian Tubules    2.8 Adult Fat Body    2.8 Adult Salivary Gland    6.8 Adult Heart    3.1 Adult VirginFemale Spermatheca    3.5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    1.3 Adult Testis no informative data Adult Male Accessory Gland    6 Adult Carcass    8.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2.2   NA  Eye    3.175   NA  Brain    1.5   0.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.7   NA  Crop    4.5   4.8  Midgut    3.3   1.3  Hindgut    1.2   2.2  Malpighian Tubules    2.8   9.1  Fat Body    2.8   1.7  Salivary Gland    6.8   NA  Heart    3.1   4.35  Trachea    NA   NA  VirginFemale Spermatheca    3.5   NA  InseminatedFemale Spermatheca    5.3   NA  Ovary    1.3   NA  Testis    no informative data   NA  Male Accessory Gland    6   2.575  Carcass    8.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030900 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15064-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Him Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | partially, with Scer\GAL4twi.PB HimScer\UAS.cLa semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 HimGD7631 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 HimGD7631 Phenotype manifest in Allele embryonic/larval muscle system, with Scer\GAL4how-24B HimScer\UAS.cLa embryonic/larval muscle system, with Scer\GAL4twi.PB HimScer\UAS.cLa HimdsRNA.Scer\UAS trichogen cell, with Scer\GAL4pnr-MD237 HimGD7631
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Him Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Him Class Mutagen Stocks Known lesion HimGD7631 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes HimKK111297 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HimdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes HimScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes HimT:Avic\GFP-m6 in vitro construct - coding region fusion 0 Yes HimΔWRPW.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7631} NA P{KK111297} NA P{UAS-Him.L} NA P{UAS-Him.RNAi} NA P{UAS-Him.ΔWRPW} NA characterization construct P{Him-GFP.L} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
	There is no information supporting a cellular component or molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
negative regulation of muscle organ development inferred from mutant phenotype (Liotta et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Him allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0030900
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22429 Dere\GG19155 Dgri\GH17719 Dmoj\GI15467 Dper\GL26966 Dpse\GA13466 Dsec\GM22887 Dsim\GD24688 Dvir\GJ19178 Dwil\GK20002 Dyak\GE17715
Curated drosophilid orthologs	Dpse\GA13466
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0235162 FBgn0221999 FBgn0206323 FBgn0196015 FBgn0177756 FBgn0073502 FBgn0164547 FBgn0138216 FBgn0125189 FBgn0111361 FBgn0099425
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v102268 P{KK111297}VIE-260B v38664 w1118; P{GD7631}v38664 v38665 w1118; P{GD7631}v38665
Genomic Clones ( 2 )
	BACR32F24 BACR48L05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 1 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE70039
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030900 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32801
Antibody Information
Other Information
Discoverer
Etymology
	The gene is an inhibitor of Mef2 activity and muscle differentiation and is named "Holes in muscle" based on this phenotype. (Liotta et al., 2007) The gene is named "Him" for its proximity to the "Her" gene. (Rebeiz et al., 2002)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Him CG15064 (Posakony, 2002.7.11)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_133045 RefSeq (Proteins) • NP_573273 DDBJ / EMBL / GenBank • AAF48811 AAL48070 AY070599 BI486590 Entrez Gene - A searchable database of RefSeq genes. • 32801 UniProtKB/TrEMBL • Q9VWX6
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0030900 DRSC - Results from RNAi screens. • FBgn0030900 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030900 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15064-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030900 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32801 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/him.htm modMine - Data generated by the modENCODE project. • FBgn0030900 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0235162 FBgn0221999 FBgn0206323 FBgn0196015 FBgn0177756 FBgn0073502 FBgn0164547 FBgn0138216 FBgn0125189 FBgn0111361 FBgn0099425 REDfly - A database of transcriptional regulatory elements. • FBgn0030900
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG15064 (Butler et al., 2003, Posakony, 2002.7.11, Krejcí et al., 2009, Keleman et al., 2009.8.5) Him (Liotta et al., 2007, Sandmann et al., 2006, Liu et al., 2009, Krejcí et al., 2009, Bernard et al., 2009, Rehmsmeier et al., 2004, Figeac et al., 2010, Bernard et al., 2010, Müller et al., 2010, Cunha et al., 2010) him (Krejcí et al., 2009)
Name Synonym	Him   Holes in muscle (Liotta et al., 2007) holes-in-muscle (Cunha et al., 2010) Holes in Muscles (Krejcí et al., 2009)
Secondary FlyBase IDs
References ( 20 )
Research paper	Bernard et al., 2010, Development 137(16): 2633--2642 Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors. [FBrf0211412] Cunha et al., 2010, PLoS Genet. 6: e1001014 Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity. [FBrf0211225] Figeac et al., 2010, Development 137(12): 1965--1973 Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway. [FBrf0210887] Müller et al., 2010, PLoS ONE 5(12): e14323 Regulation and Functions of the lms Homeobox Gene during Development of Embryonic Lateral Transverse Muscles and Direct Flight Muscles in Drosophila. [FBrf0212632] Bernard et al., 2009, Dev. Biol. 332(2): 258--272 Integration of differentiation signals during indirect flight muscle formation by a novel enhancer of Drosophila vestigial gene. [FBrf0208388] Krejcí et al., 2009, Sci. Signal. 2(55): ra1 Direct response to Notch activation: signaling crosstalk and incoherent logic. [FBrf0206734] Liu et al., 2009, Dev. Cell 16(2): 280--291 A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development. [FBrf0206680] Liotta et al., 2007, Curr. Biol. 17(16): 1409--1413 The Him gene reveals a balance of inputs controlling muscle differentiation in Drosophila. [FBrf0201412] Sandmann et al., 2006, Dev. Cell 10(6): 797--807 A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development. [FBrf0193172] Rehmsmeier et al., 2004, RNA, N.Y. 10(10): 1507--1517 Fast and effective prediction of microRNA/target duplexes. [FBrf0180666] Butler et al., 2003, Development 130(4): 659--670 Discovery of genes with highly restricted expression patterns in the Drosophila wing disc using DNA oligonucleotide microarrays. [FBrf0155718] Rebeiz et al., 2002, Proc. Natl. Acad. Sci. USA 99(15): 9888--9893 SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. [FBrf0152326]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Posakony, 2002.7.11, FlyBase error report for CG15064 on Thu Jul 11 15:27:19 2002. FlyBase error report for CG15064 on Thu Jul 11 15:27:19 2002. [FBrf0155325]
FlyBase analysis	FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]