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Gene Dmel\upd2

General Information
Symbol	Dmel\upd2	Species	D. melanogaster
Name	unpaired 2	Annotation symbol	CG5988
Feature type	protein_coding_gene	FlyBase ID	FBgn0030904
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	17A3-17A3	Sequence location	X:18,134,790..18,137,317 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene unpaired 2 is referred to in FlyBase by the symbol Dmel\upd2 (CG5988, FBgn0030904). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: paracrine signaling; segment specification; positive regulation of JAK-STAT cascade. 9 alleles are reported. The phenotype of these alleles is annotated with: wing. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1623718_at partially aligns to an exonic region of the only FlyBase-annotated transcript isoform of upd2: 12 out of 14 probes fall into this exonic region. Gene sequence location is X:18134790..18137317.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Feng et al., 2011, EMBO Rep. 12(2): 157--163 Vidal et al., 2010, J. Cell Sci. 123(20): 3457--3466
FB2012_01	Sequence features HFA19969 BKN31939
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 17A3-17A3   Limits computationally determined from genome sequence between P{EP}ari-1EP317 and P{EP}EP1378
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\upd2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Extended 3' UTR based on RNA-Seq data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) upd2-RB FBtr0300182  NM_133049   1877   370
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein upd2-PB   FBpp0289419   41.7   370   9.54     NP_573277   AAF48815
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48815   BT122045   EY198580   GH291395
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VWX2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9   organism | segmentally repeated & striped   (Hombria et al., 2005) embryonic stage 10   trachea   (Hombria et al., 2005) Comment:tracheal expression is transient embryonic stage 11   hindgut   (Hombria et al., 2005) posterior spiracle primordium   (Hombria et al., 2005)
Additional Descriptive Data
	upd2 is expressed in segmentally repeated stripes at embryonic stage 9. At embryonic stage 10, upd2 has transient tracheal expression. At embryonic stage 11, the tracheal expression of upd2 has been replaced with expression in the hindgut and posterior spiracles. (Hombria et al., 2005)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030904    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030904 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030904 expression level Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    390 embryo 04-06hr    898 embryo 06-08hr    256 embryo 08-10hr    154 embryo 10-12hr    60 embryo 12-14hr    31 embryo 14-16hr    38 embryo 16-18hr    44 embryo 18-20hr    133 embryo 20-22hr    74 embryo 22-24hr    61 larva L1    15 larva L2    9 larva L3 12hr old    19 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    22 white prepupae new    26 white prepupae 12hr    246 white prepupae 24hr    125 pupae 2d postWPP    83 pupae 3d postWPP    26 pupae 4d postWPP    63 adult male 01day    8 adult male 05day    13 adult male 30day    44 adult female 01day    12 adult female 05day    8 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr  (390) embryo 04-06hr  (898) embryo 06-08hr  (256) embryo 08-10hr  (154) embryo 10-12hr    60 embryo 12-14hr    31 embryo 14-16hr    38 embryo 16-18hr    44 embryo 18-20hr  (133) embryo 20-22hr    74 embryo 22-24hr    61 larva L1    15 larva L2    9 larva L3 12hr old    19 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    22 white prepupae new    26 white prepupae 12hr  (246) white prepupae 24hr  (125) pupae 2d postWPP    83 pupae 3d postWPP    26 pupae 4d postWPP    63 adult male 01day    8 adult male 05day    13 adult male 30day    44 adult female 01day    12 adult female 05day    8 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    390 embryo 04-06hr    898 embryo 06-08hr    256 embryo 08-10hr    154 embryo 10-12hr    60 embryo 12-14hr    31 embryo 14-16hr    38 embryo 16-18hr    44 embryo 18-20hr    133 embryo 20-22hr    74 embryo 22-24hr    61 larva L1    15 larva L2    9 larva L3 12hr old    19 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    22 white prepupae new    26 white prepupae 12hr    246 white prepupae 24hr    125 pupae 2d postWPP    83 pupae 3d postWPP    26 pupae 4d postWPP    63 adult male 01day    8 adult male 05day    13 adult male 30day    44 adult female 01day    12 adult female 05day    8 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    390 embryo 04-06hr    898 embryo 06-08hr    256 embryo 08-10hr    154 embryo 10-12hr    60 embryo 12-14hr    31 embryo 14-16hr    38 embryo 16-18hr    44 embryo 18-20hr    133 embryo 20-22hr    74 embryo 22-24hr    61 larva L1    15 larva L2    9 larva L3 12hr old    19 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    22 white prepupae new    26 white prepupae 12hr    246 white prepupae 24hr    125 pupae 2d postWPP    83 pupae 3d postWPP    26 pupae 4d postWPP    63 adult male 01day    8 adult male 05day    13 adult male 30day    44 adult female 01day    12 adult female 05day    8 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    390 embryo 04-06hr    898 embryo 06-08hr    256 embryo 08-10hr    154 embryo 10-12hr    60 embryo 12-14hr    31 embryo 14-16hr    38 embryo 16-18hr    44 embryo 18-20hr    133 embryo 20-22hr    74 embryo 22-24hr    61 larva L1    15 larva L2    9 larva L3 12hr old    19 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    22 white prepupae new    26 white prepupae 12hr    246 white prepupae 24hr    125 pupae 2d postWPP    83 pupae 3d postWPP    26 pupae 4d postWPP    63 adult male 01day    8 adult male 05day    13 adult male 30day    44 adult female 01day    12 adult female 05day    8 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030904 expression level Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    390 embryo 04-06hr    898 embryo 06-08hr    256 embryo 08-10hr    154 embryo 10-12hr    60 embryo 12-14hr    31 embryo 14-16hr    38 embryo 16-18hr    44 embryo 18-20hr    133 embryo 20-22hr    74 embryo 22-24hr    61 larva L1    15 larva L2    9 larva L3 12hr old    19 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    22 white prepupae new    26 white prepupae 12hr    246 white prepupae 24hr    125 pupae 2d postWPP    83 pupae 3d postWPP    26 pupae 4d postWPP    63 adult male 01day    8 adult male 05day    13 adult male 30day    44 adult female 01day    12 adult female 05day    8 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr  (390) embryo 04-06hr  (898) embryo 06-08hr  (256) embryo 08-10hr  (154) embryo 10-12hr    60 embryo 12-14hr    31 embryo 14-16hr    38 embryo 16-18hr    44 embryo 18-20hr  133 embryo 20-22hr    74 embryo 22-24hr    61 larva L1    15 larva L2    9 larva L3 12hr old    19 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    22 white prepupae new    26 white prepupae 12hr  (246) white prepupae 24hr  125 pupae 2d postWPP    83 pupae 3d postWPP    26 pupae 4d postWPP    63 adult male 01day    8 adult male 05day    13 adult male 30day    44 adult female 01day    12 adult female 05day    8 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    390 embryo 04-06hr    898 embryo 06-08hr    256 embryo 08-10hr    154 embryo 10-12hr    60 embryo 12-14hr    31 embryo 14-16hr    38 embryo 16-18hr    44 embryo 18-20hr    133 embryo 20-22hr    74 embryo 22-24hr    61 larva L1    15 larva L2    9 larva L3 12hr old    19 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    22 white prepupae new    26 white prepupae 12hr    246 white prepupae 24hr    125 pupae 2d postWPP    83 pupae 3d postWPP    26 pupae 4d postWPP    63 adult male 01day    8 adult male 05day    13 adult male 30day    44 adult female 01day    12 adult female 05day    8 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    390 embryo 04-06hr    898 embryo 06-08hr    256 embryo 08-10hr    154 embryo 10-12hr    60 embryo 12-14hr    31 embryo 14-16hr    38 embryo 16-18hr    44 embryo 18-20hr    133 embryo 20-22hr    74 embryo 22-24hr    61 larva L1    15 larva L2    9 larva L3 12hr old    19 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    22 white prepupae new    26 white prepupae 12hr    246 white prepupae 24hr    125 pupae 2d postWPP    83 pupae 3d postWPP    26 pupae 4d postWPP    63 adult male 01day    8 adult male 05day    13 adult male 30day    44 adult female 01day    12 adult female 05day    8 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    390 embryo 04-06hr    898 embryo 06-08hr    256 embryo 08-10hr    154 embryo 10-12hr    60 embryo 12-14hr    31 embryo 14-16hr    38 embryo 16-18hr    44 embryo 18-20hr    133 embryo 20-22hr    74 embryo 22-24hr    61 larva L1    15 larva L2    9 larva L3 12hr old    19 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    22 white prepupae new    26 white prepupae 12hr    246 white prepupae 24hr    125 pupae 2d postWPP    83 pupae 3d postWPP    26 pupae 4d postWPP    63 adult male 01day    8 adult male 05day    13 adult male 30day    44 adult female 01day    12 adult female 05day    8 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030904    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030904 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030904 expression level Tissue   Expression Level Larval Central Nervous System    0.725 Larval Midgut    1.7 Larval Hindgut    1.5 Larval Malpighian Tubules    1.1 Larval Fat Body    2.1 Larval Salivary Gland    3.2 Larval Trachea    1.925 Larval Carcass    0.9 Adult Head    0.9 Adult Eye    2.3 Adult Brain    0.7 Adult Thoracic-Abdominal Ganglion    1 Adult Crop    2.8 Adult Midgut    1.5 Adult Hindgut    1 Adult Malpighian Tubules    1.4 Adult Fat Body    1 Adult Salivary Gland    3.1 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1.6 Adult Male Accessory Gland    1.4 Adult Carcass    1.3 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.725 Larval Midgut    1.7 Larval Hindgut    1.5 Larval Malpighian Tubules    1.1 Larval Fat Body    2.1 Larval Salivary Gland    3.2 Larval Trachea    1.925 Larval Carcass    0.9 Adult Head    0.9 Adult Eye    2.3 Adult Brain    0.7 Adult Thoracic-Abdominal Ganglion    1 Adult Crop    2.8 Adult Midgut    1.5 Adult Hindgut    1 Adult Malpighian Tubules    1.4 Adult Fat Body    1 Adult Salivary Gland    3.1 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1.6 Adult Male Accessory Gland    1.4 Adult Carcass    1.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.725 Larval Midgut    1.7 Larval Hindgut    1.5 Larval Malpighian Tubules    1.1 Larval Fat Body    2.1 Larval Salivary Gland    3.2 Larval Trachea    1.925 Larval Carcass    0.9 Adult Head    0.9 Adult Eye    2.3 Adult Brain    0.7 Adult Thoracic-Abdominal Ganglion    1 Adult Crop    2.8 Adult Midgut    1.5 Adult Hindgut    1 Adult Malpighian Tubules    1.4 Adult Fat Body    1 Adult Salivary Gland    3.1 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1.6 Adult Male Accessory Gland    1.4 Adult Carcass    1.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.725 Larval Midgut    1.7 Larval Hindgut    1.5 Larval Malpighian Tubules    1.1 Larval Fat Body    2.1 Larval Salivary Gland    3.2 Larval Trachea    1.925 Larval Carcass    0.9 Adult Head    0.9 Adult Eye    2.3 Adult Brain    0.7 Adult Thoracic-Abdominal Ganglion    1 Adult Crop    2.8 Adult Midgut    1.5 Adult Hindgut    1 Adult Malpighian Tubules    1.4 Adult Fat Body    1 Adult Salivary Gland    3.1 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1.6 Adult Male Accessory Gland    1.4 Adult Carcass    1.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030904 expression level Tissue   Expression Level Larval Central Nervous System    0.725 Larval Midgut    1.7 Larval Hindgut    1.5 Larval Malpighian Tubules    1.1 Larval Fat Body    2.1 Larval Salivary Gland    3.2 Larval Trachea    1.925 Larval Carcass    0.9 Adult Head    0.9 Adult Eye    2.3 Adult Brain    0.7 Adult Thoracic-Abdominal Ganglion    1 Adult Crop    2.8 Adult Midgut    1.5 Adult Hindgut    1 Adult Malpighian Tubules    1.4 Adult Fat Body    1 Adult Salivary Gland    3.1 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1.6 Adult Male Accessory Gland    1.4 Adult Carcass    1.3 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.725 Larval Midgut    1.7 Larval Hindgut    1.5 Larval Malpighian Tubules    1.1 Larval Fat Body    2.1 Larval Salivary Gland    3.2 Larval Trachea    1.925 Larval Carcass    0.9 Adult Head    0.9 Adult Eye    2.3 Adult Brain    0.7 Adult Thoracic-Abdominal Ganglion    1 Adult Crop    2.8 Adult Midgut    1.5 Adult Hindgut    1 Adult Malpighian Tubules    1.4 Adult Fat Body    1 Adult Salivary Gland    3.1 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1.6 Adult Male Accessory Gland    1.4 Adult Carcass    1.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.725 Larval Midgut    1.7 Larval Hindgut    1.5 Larval Malpighian Tubules    1.1 Larval Fat Body    2.1 Larval Salivary Gland    3.2 Larval Trachea    1.925 Larval Carcass    0.9 Adult Head    0.9 Adult Eye    2.3 Adult Brain    0.7 Adult Thoracic-Abdominal Ganglion    1 Adult Crop    2.8 Adult Midgut    1.5 Adult Hindgut    1 Adult Malpighian Tubules    1.4 Adult Fat Body    1 Adult Salivary Gland    3.1 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1.6 Adult Male Accessory Gland    1.4 Adult Carcass    1.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.725 Larval Midgut    1.7 Larval Hindgut    1.5 Larval Malpighian Tubules    1.1 Larval Fat Body    2.1 Larval Salivary Gland    3.2 Larval Trachea    1.925 Larval Carcass    0.9 Adult Head    0.9 Adult Eye    2.3 Adult Brain    0.7 Adult Thoracic-Abdominal Ganglion    1 Adult Crop    2.8 Adult Midgut    1.5 Adult Hindgut    1 Adult Malpighian Tubules    1.4 Adult Fat Body    1 Adult Salivary Gland    3.1 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1.6 Adult Male Accessory Gland    1.4 Adult Carcass    1.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    0.9   NA  Eye    2.3   NA  Brain    0.7   0.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1   NA  Crop    2.8   1.7  Midgut    1.5   1.5  Hindgut    1   1.1  Malpighian Tubules    1.4   2.1  Fat Body    1   3.2  Salivary Gland    3.1   NA  Heart    0.875   1.925  Trachea    NA   NA  VirginFemale Spermatheca    1.5   NA  InseminatedFemale Spermatheca    1.5   NA  Ovary    0.9   NA  Testis    1.6   NA  Male Accessory Gland    1.4   0.9  Carcass    1.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030904 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5988-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 upd2GD6513 viable | recessive upd2Δ3-62 Sterility Allele fertile | recessive upd2Δ3-62 Phenotype manifest in Allele wing, with Scer\GAL4Bx-MS1096 upd2Scer\UAS.T:Avic\GFP-EGFP
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of upd2 Class Mutagen Stocks Known lesion upd2G1031 P-element activity 0 Yes upd2Δ3-62 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of upd2 Class Mutagen Stocks Known lesion upd2GD6513 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes upd2HMS00901 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes upd2HMS00948 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes upd2Act5C.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes upd2Act5C.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes upd2Scer\UAS.cWa in vitro construct - regulatory fusion 0 Yes upd2Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)os1A2 (Hombria et al., 2005)
Not disrupted in	Df(1)osUE69 (Hombria et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6513} NA P{TRiP.HMS00901} NA P{TRiP.HMS00948} NA P{UAS-upd2.EGFP} NA P{UAS-upd2.W} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{Mae-UAS.6.11}upd2G1031 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
paracrine signaling inferred from direct assay (Wright et al., 2011) positive regulation of JAK-STAT cascade inferred from direct assay (Hombria et al., 2005, Wright et al., 2011) inferred from genetic interaction with dome (Wright et al., 2011) inferred from genetic interaction with hop (Wright et al., 2011) inferred from genetic interaction with Ptp61F (Wright et al., 2011) inferred from genetic interaction with Socs36E (Wright et al., 2011) inferred from genetic interaction with Stat92E (Wright et al., 2011) segment specification inferred from mutant phenotype (Hombria et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions upd2 allele Gene References unspecified dome (Hombria et al., 2005)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0030904
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22520 Dere\GG18137 Dgri\GH17793 Dmoj\GI15132 Dper\GL27046 Dpse\GA19279 Dsec\GM22829 Dsim\GD15650 Dvir\GJ18992 Dwil\GK19872 Dyak\GE15548
Curated drosophilid orthologs	Dana\upd2 (Hombria et al., 2005) Dmoj\upd2 (Hombria et al., 2005) Dpse\GA19279   Dvir\upd2 (Hombria et al., 2005) Dyak\upd2 (Hombria et al., 2005)
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233121 FBgn0221870 FBgn0206138 FBgn0187312 FBgn0177699 FBgn0079276 FBgn0164627 FBgn0137882 FBgn0125263 FBgn0110353 FBgn0099514
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	33949 y1 sc* v1; P{TRiP.HMS00901}attP2 33988 y1 sc* v1; P{TRiP.HMS00948}attP2
VDRC	v14664 w1118; P{GD6513}v14664
Genomic Clones ( 1 )
	BACR32F24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 3 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	RT06576
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	DMG2-chrX.19.009.a DMG6-chrX.32.006.pred.a
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030904 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32805
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CG5988 upd2 (Agaisse and Perrimon, 2004)
Source for database merge of
Additional comments	"upd" and "os" can be genetically separated. This raises the possibility that "os" function may reside with an "upd-like" gene ("upd2" or "upd3"). (Wang, 2005)
Other Comments
	Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB. (Liu and Lehmann, 2008) upd2 is not required for os-induced JAK/STAT signalling. (Baeg et al., 2005) S2-derived S2-NP cells transfected with dsRNA made from templates generated with primers directed against upd2 exhibit a reduction in JAK/STAT activity, indicating upd2 is involved in the positive regulation of JAK/STAT signalling in these cells. (Baeg et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_133049 RefSeq (Proteins) • NP_573277 DDBJ / EMBL / GenBank • AAF48815 Entrez Gene - A searchable database of RefSeq genes. • 32805 UniProtKB/TrEMBL • Q9VWX2
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0030904 DRSC - Results from RNAi screens. • FBgn0030904 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030904 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5988-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030904 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 205656 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32805 modMine - Data generated by the modENCODE project. • FBgn0030904 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233121 FBgn0221870 FBgn0206138 FBgn0187312 FBgn0177699 FBgn0079276 FBgn0164627 FBgn0137882 FBgn0125263 FBgn0110353 FBgn0099514
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG5988 (Ringrose et al., 2003, Agaisse et al., 2003, Hou et al., 2002, Castelli-Gair Hombria and Brown, 2002, Baeg et al., 2007, Brown et al., 2006, Wawersik et al., 2005, Ni et al., 2010.12.1, Wright et al., 2011) cg5988 (Brown et al., 2003) Upd2 (Baeg et al., 2005, Zeidler et al., 2005, Pei and Harrison, 2007, Jiang et al., 2009, Rivas et al., 2008, Ren et al., 2010, Jiang et al., 2011, Wright et al., 2011, Vidal et al., 2010) upd2 (Wang and Harrison, 2007, Hombria et al., 2005, Krzemien et al., 2007, Wang and Harrison, 2008, Liu and Lehmann, 2008, Wawersik et al., 2005, López-Onieva et al., 2008, Classen et al., 2009, Beebe et al., 2010, Sotillos et al., 2010, Pastor-Pareja et al., 2008, Wright et al., 2011, Feng et al., 2011) UPD2 (Castelli-Gair Hombria, 2006, Arbouzova and Zeidler, 2006)
Name Synonym	unpaired 2 (Agaisse and Perrimon, 2004, Kula-Eversole and Hatini, 2007, Hauenschild et al., 2008, Hill-Burns and Clark, 2009) Unpaired2 (Sotillos et al., 2008)
Secondary FlyBase IDs
References ( 47 )
Generate a list of	All references relating to this gene ( 47 )
List References by type	Research paper  ( 26 ) Supplementary material  ( 1 ) Review  ( 6 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 2 ) Abstract  ( 9 ) FlyBase analysis  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 8 )
	Feng et al., 2011, EMBO Rep. 12(2): 157--163 Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation. [FBrf0214189] Jiang et al., 2011, Cell Stem Cell 8(1): 84--95 EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. [FBrf0212694] Wright et al., 2011, Cell. Signal. 23(5): 920--927 Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. [FBrf0213113] Beebe et al., 2010, Dev. Biol. 338(1): 28--37 JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. [FBrf0209772] Karpowicz et al., 2010, Development 137(24): 4135--4145 The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. [FBrf0212383] Ren et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(49): 21064--21069 Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. [FBrf0212502] Sotillos et al., 2010, Dev. Biol. 340(2): 571--582 An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development. [FBrf0210508] Vidal et al., 2010, J. Cell Sci. 123(20): 3457--3466 Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking. [FBrf0211993] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...