FB2020_02, released Apr 14, 2020

Gene: Dmel\CCKLR-17D3

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General Information
Symbol
Dmel\CCKLR-17D3
Species
D. melanogaster
Name
Cholecystokinin-like receptor at 17D3
Annotation Symbol
CG32540
Feature Type
protein_coding_gene
FlyBase ID
FBgn0030954
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Snapshot
Cholecystokinin-like receptor at 17D3 (CCKLR-17D3) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Dsk. It acts through the cAMP-PKA-CREB pathway and it is needed for the growth of neuromuscular junctions. It regulates food ingestion, satiety, hyperactivity, aggression and escape-related locomotion. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

DSK-R1

Key Links
Genomic Location
Cytogenetic map
17D3-17D4
Sequence location
X:18,764,483..18,774,027 [-]
Recombination map

1-60

RefSeq locus
NC_004354 REGION:18764483..18774027
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
G protein-coupled receptor activity; gastrin receptor activity; neuropeptide receptor activity
Summaries
Gene Group (FlyBase)
CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS -
The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\CCKLR-17D3 or the JBrowse view of Dmel\CCKLR-17D3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

RNAseq data also supports the deletion of CCKLR-17D3-RA; the transcript model supported by cDNAs fails to correspond to either exon junctions or RPKM values.

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CCKLR-17D3-RB
FBtr0113003
NM_001103553
2230
584
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CCKLR-17D3-PB
FBpp0111916
62.2
584
8.09
NP_001097023
AAF48879
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CCKLR-17D3 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (6 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
G protein-coupled receptor activity
inferred from sequence or structural similarity
(Radford et al., 2002, Brody and Cravchik, 2000)
gastrin receptor activity
inferred from electronic annotation with InterPro:IPR000314
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
neuropeptide receptor activity
inferred from sequence model
(Hewes and Taghert, 2001)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
adult locomotory behavior
inferred from mutant phenotype
(Kiss et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
G protein-coupled receptor signaling pathway
inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR000314, InterPro:IPR009126
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
inferred from sequence model
(Hewes and Taghert, 2001)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
integral component of membrane
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred from sequence model
(Hewes and Taghert, 2001)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CCKLR-17D3 in GBrowse 2
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CCKLR-17D3
Transgenic constructs containing regulatory region of CCKLR-17D3
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CCKAR
11 of 15
Yes
Yes
Hsap\CCKBR
10 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cckar
10 of 15
Yes
Yes
Mmus\Cckbr
10 of 15
Yes
No
Rattus norvegicus (Norway rat) (2)
Rnor\Cckar
10 of 13
Yes
Yes
Rnor\Cckbr
9 of 13
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\cckar
7 of 12
Yes
Yes
Xtro\LOC101732125
2 of 12
No
Yes
Danio rerio (Zebrafish) (3)
Drer\cckar
11 of 15
Yes
Yes
Drer\LOC100331465
11 of 15
Yes
Yes
Drer\si:dkey-1h24.2
10 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\ckr-2
12 of 15
Yes
Yes
Cele\ckr-1
10 of 15
No
Yes
Cele\C34B4.3
1 of 15
No
Yes
Cele\gnrr-7
1 of 15
No
No
Cele\R13H4.7
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190BSA )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD15618
Drosophila sechellia
Dsec\GM22785
Drosophila erecta
Dere\GG18093
Drosophila yakuba
Dyak\GE15490
Drosophila ananassae
Dana\GF19219
Drosophila pseudoobscura pseudoobscura
Dpse\GA22339
Drosophila persimilis
Dper\GL27009
Drosophila willistoni
Dwil\GK24944
Drosophila virilis
Dvir\GJ18588
Drosophila mojavensis
Dmoj\GI10925
Drosophila grimshawi
Dgri\GH12199
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507DT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011034
Musca domestica
House fly
Mdoa\17018130
Musca domestica
House fly
Mdoa\17005790
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04924
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11231
Mayetiola destructor
Hessian fly
Mdes\Mdes006795
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRCCK1_2
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016281
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016282
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0H5Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03635
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04577
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_08438
Pediculus humanus
Human body louse
Phum\PHUM615310
Cimex lectularius
Bed bug
Clec\CLEC025148
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0B4W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005790
Ixodes scapularis
Black-legged tick
Isca\ISCW005570
Ixodes scapularis
Black-legged tick
Isca\ISCW005948
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_53990
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (10)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CCKLR-17D1
7 of 10
RYa-R
2 of 10
AkhR
1 of 10
CCAP-R
1 of 10
CG13575
1 of 10
CG32547
1 of 10
CrzR
1 of 10
SIFaR
1 of 10
TkR86C
1 of 10
TkR99D
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
CCKAR; cholecystokinin A receptor
11 of 15
118444
      CCKBR; cholecystokinin B receptor
      10 of 15
      118445
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Interactions Browser
          Summary of Genetic Interactions
          esyN Network Diagram
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          X
          Recombination map

          1-60

          Cytogenetic map
          17D3-17D4
          Sequence location
          X:18,764,483..18,774,027 [-]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          17D3-17D4
          Limits computationally determined from genome sequence between P{EP}EP443EP443&P{EP}BxEP1383 and P{EP}Pk17EEP438
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          1-60

          (FlyBase, 2016)

          1-59.9

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (9)
          Genomic Clones (20)
          cDNA Clones (5)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequences
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of

            Source for identity of: CCKLR-17D3 CG6894

            (McBride, 2001.3.16)
            Source for database merge of

            Source for merge of: CCKLR-17D3 anon-WO0170980.64 anon-WO0170980.65

            (FlyBase, 1996-)

            Source for merge of: CCKLR-17D3 CG6881

            (McBride, 2001.3.16)
            Additional comments

            Annotations CG6881, CG6894 merged as CG32540 in release 3 of the genome annotation.

            (FlyBase Genome Annotators, 2002-2003)

            Source for merge of CCKLR-17D3 anon-WO0170980.64 anon-WO0170980.65 was sequence comparison ( date:051113 ).

            (FlyBase, 1996-)
            Other Comments
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 30 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            Synonyms and Secondary IDs (16)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (58)