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Gene Dmel\CCKLR-17D3

General Information
Symbol	Dmel\CCKLR-17D3	Species	D. melanogaster
Name	CCK-like receptor at 17D3	Annotation symbol	CG32540
Feature type	protein_coding_gene	FlyBase ID	FBgn0030954
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	CG6894, CG6881
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	17D3-17D4	Sequence location	X:18,658,516..18,668,264 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene CCK-like receptor at 17D3 is referred to in FlyBase by the symbol Dmel\CCKLR-17D3 (CG32540, FBgn0030954). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: G-protein coupled receptor activity; neuropeptide receptor activity; cholecystokinin receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process: G-protein coupled receptor signaling pathway. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cholecystokinin receptor; G protein-coupled receptor, rhodopsin-like; GPCR, rhodopsin-like, 7TM; Gastrin receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1625577_at partially aligns to an exonic region of the only FlyBase-annotated transcript isoform of CCKLR-17D3: 10 out of 14 probes fall into this exonic region. Gene sequence location is X:18658516..18668264.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 17D3-17D4   Limits computationally determined from genome sequence between P{EP}EP443EP443&P{EP}BxEP1383 and P{EP}Pk17EEP438
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CCKLR-17D3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CCKLR-17D3-RB FBtr0113003  NM_001103553   2434   584
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CCKLR-17D3-PB   FBpp0111916   62.2   584   8.09     NP_001097023   AAF48879
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • G protein-coupled receptor, rhodopsin-like (IPR000276) Gastrin receptor (IPR000314) Cholecystokinin receptor (IPR009126) GPCR, rhodopsin-like, 7TM (IPR017452)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48879   AX128640   AX254497   AX254498   AY231149 AAP69665   BT023113   BT031100   CO318111   DD177537   EC204270   EL869775
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7M3J6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    1.3 Larval Hindgut    1 Larval Malpighian Tubules    1.1 Larval Fat Body    1.7 Larval Salivary Gland    1.4 Larval Trachea    1.35 Larval Carcass    1.95 Adult Head    1.5 Adult Eye    1.075 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    1 Adult Midgut    1.1 Adult Hindgut    0.9 Adult Malpighian Tubules    1.1 Adult Fat Body    1.8 Adult Salivary Gland    6.2 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1 Adult Male Accessory Gland    1.7 Adult Carcass    1.4 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    1.3 Larval Hindgut    1 Larval Malpighian Tubules    1.1 Larval Fat Body    1.7 Larval Salivary Gland    1.4 Larval Trachea    1.35 Larval Carcass    1.95 Adult Head    1.5 Adult Eye    1.075 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    1 Adult Midgut    1.1 Adult Hindgut    0.9 Adult Malpighian Tubules    1.1 Adult Fat Body    1.8 Adult Salivary Gland    6.2 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1 Adult Male Accessory Gland    1.7 Adult Carcass    1.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    1.3 Larval Hindgut    1 Larval Malpighian Tubules    1.1 Larval Fat Body    1.7 Larval Salivary Gland    1.4 Larval Trachea    1.35 Larval Carcass    1.95 Adult Head    1.5 Adult Eye    1.075 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    1 Adult Midgut    1.1 Adult Hindgut    0.9 Adult Malpighian Tubules    1.1 Adult Fat Body    1.8 Adult Salivary Gland    6.2 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1 Adult Male Accessory Gland    1.7 Adult Carcass    1.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    1.3 Larval Hindgut    1 Larval Malpighian Tubules    1.1 Larval Fat Body    1.7 Larval Salivary Gland    1.4 Larval Trachea    1.35 Larval Carcass    1.95 Adult Head    1.5 Adult Eye    1.075 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    1 Adult Midgut    1.1 Adult Hindgut    0.9 Adult Malpighian Tubules    1.1 Adult Fat Body    1.8 Adult Salivary Gland    6.2 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1 Adult Male Accessory Gland    1.7 Adult Carcass    1.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    1.3 Larval Hindgut    1 Larval Malpighian Tubules    1.1 Larval Fat Body    1.7 Larval Salivary Gland    1.4 Larval Trachea    1.35 Larval Carcass    1.95 Adult Head    1.5 Adult Eye    1.075 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    1 Adult Midgut    1.1 Adult Hindgut    0.9 Adult Malpighian Tubules    1.1 Adult Fat Body    1.8 Adult Salivary Gland    6.2 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1 Adult Male Accessory Gland    1.7 Adult Carcass    1.4 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    1.3 Larval Hindgut    1 Larval Malpighian Tubules    1.1 Larval Fat Body    1.7 Larval Salivary Gland    1.4 Larval Trachea    1.35 Larval Carcass    1.95 Adult Head    1.5 Adult Eye    1.075 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    1 Adult Midgut    1.1 Adult Hindgut    0.9 Adult Malpighian Tubules    1.1 Adult Fat Body    1.8 Adult Salivary Gland    6.2 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1 Adult Male Accessory Gland    1.7 Adult Carcass    1.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    1.3 Larval Hindgut    1 Larval Malpighian Tubules    1.1 Larval Fat Body    1.7 Larval Salivary Gland    1.4 Larval Trachea    1.35 Larval Carcass    1.95 Adult Head    1.5 Adult Eye    1.075 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    1 Adult Midgut    1.1 Adult Hindgut    0.9 Adult Malpighian Tubules    1.1 Adult Fat Body    1.8 Adult Salivary Gland    6.2 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1 Adult Male Accessory Gland    1.7 Adult Carcass    1.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.6 Larval Midgut    1.3 Larval Hindgut    1 Larval Malpighian Tubules    1.1 Larval Fat Body    1.7 Larval Salivary Gland    1.4 Larval Trachea    1.35 Larval Carcass    1.95 Adult Head    1.5 Adult Eye    1.075 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    5.6 Adult Crop    1 Adult Midgut    1.1 Adult Hindgut    0.9 Adult Malpighian Tubules    1.1 Adult Fat Body    1.8 Adult Salivary Gland    6.2 Adult Heart    0.875 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    0.9 Adult Testis    1 Adult Male Accessory Gland    1.7 Adult Carcass    1.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1.5   NA  Eye    1.075   NA  Brain    no informative data   2.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    5.6   NA  Crop    1   1.3  Midgut    1.1   1  Hindgut    0.9   1.1  Malpighian Tubules    1.1   1.7  Fat Body    1.8   1.4  Salivary Gland    6.2   NA  Heart    0.875   1.35  Trachea    NA   NA  VirginFemale Spermatheca    1.3   NA  InseminatedFemale Spermatheca    1.5   NA  Ovary    0.9   NA  Testis    1   NA  Male Accessory Gland    1.7   1.95  Carcass    1.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    2 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    6 white prepupae 24hr    15 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    6 white prepupae 24hr    15 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    6 white prepupae 24hr    15 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    6 white prepupae 24hr    15 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    6 white prepupae 24hr    15 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    6 white prepupae 24hr    15 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    6 white prepupae 24hr    15 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    2 embryo 14-16hr    3 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    6 white prepupae 24hr    15 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    3 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030954 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32540-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CCKLR-17D3GD731 CCKLR-17D3GD3431 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CCKLR-17D3 Class Mutagen Stocks Known lesion CCKLR-17D3KG01373 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CCKLR-17D3 Class Mutagen Stocks Known lesion CCKLR-17D3GD3431 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CCKLR-17D3GD731 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CCKLR-17D3JF02968 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CCKLR-17D3KK110484 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CCKLR-17D3NIG.6881R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel7464 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD731} NA P{GD3431} NA P{KK110484} NA P{NIG.6881R} NA P{TRiP.JF02968} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}CCKLR-17D3KG01373 NA P{SUPor-P}KG01171 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
cholecystokinin receptor activity inferred from sequence or structural similarity with mouse Cckar (FlyBase, 1992-) gastrin receptor activity inferred from electronic annotation with InterPro:IPR000314 (FlyBase Curators et al., 2004-) G-protein coupled receptor activity inferred from sequence or structural similarity (Brody and Cravchik, 2000, Radford et al., 2002) neuropeptide receptor activity inferred from sequence or structural similarity (Hewes and Taghert, 2001)
Biological Process
CV term Evidence References
G-protein coupled receptor signaling pathway inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR000314, InterPro:IPR009126 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Hewes and Taghert, 2001, Brody and Cravchik, 2000)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR000314, InterPro:IPR009126 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Hewes and Taghert, 2001, Brody and Cravchik, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CCKLR-17D3 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0030954 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32864
Orthologs
OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG666W5W Dipteran inclusive ortholog search EOG6Z8Z5Q Insect inclusive ortholog search EOG6Q83TM Arthropod inclusive ortholog search EOG673N7D Metazoa inclusive ortholog search EOG69PPT0
Orthologs in Drosophila Species (EOG666W5W)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CCKLR-17D3     Drosophila simulans   Dsim\GD15618 Y   Drosophila sechellia   Dsec\GM22785 Y   Drosophila yakuba   Dyak\GE15490 Y   Drosophila ananassae   Dana\GF19219 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22339 Y   Drosophila persimilis   Dper\GL27009 Y   Drosophila grimshawi   Dgri\GH12199 Y
Orthologs in non-Drosophila Dipterans (EOG6Z8Z5Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL017238 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016281 Y
Orthologs in non-Dipteran Insects (EOG6Q83TM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45613 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020568 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020569 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020570 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020571 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17689 Y Atta cephalotes Leafcutter ant  Acep\ACEP10412 Y Atta cephalotes Leafcutter ant  Acep\ACEP10411 Y Atta cephalotes Leafcutter ant  Acep\ACEP25374 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12702 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19814 Y Linepithema humile Argentine ant  Lhum\LH11082 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20580 Y Solenopsis invicta Red fire ant  Sinv\SINV20738 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001300 Y Pediculus humanus Human body louse  Phum\PHUM615310 Y Pediculus humanus Human body louse  Phum\PHUM507060 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_08438 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_07536 Y
Orthologs in non-Insect Arthropods (EOG673N7D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COPS4 Y Daphnia pulex Water flea  Dpux\JGI_V11_317149 Y Ixodes scapularis Deer tick  Isca\ISCW007293 Y Ixodes scapularis Deer tick  Isca\ISCW005948 Y Ixodes scapularis Deer tick  Isca\ISCW009627 Y Ixodes scapularis Deer tick  Isca\ISCW001892 Y
Orthologs in non-Arthropod Metazoa (EOG69PPT0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\ENSDARG00000076824 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15618 Drosophila sechellia Dsec\GM22785 Drosophila erecta Dere\GG18093 Drosophila yakuba Dyak\GE15490 Drosophila ananassae Dana\GF19219 Drosophila pseudoobscura pseudoobscura Dpse\GA22339 Drosophila persimilis Dper\GL27009 Drosophila virilis Dvir\GJ18588 Drosophila mojavensis Dmoj\GI10925 Drosophila grimshawi Dgri\GH12199
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	28333 y1 v1; P{TRiP.JF02968}attP2/TM3, Sb1 13429 C(1;Y)1, y1 P{SUPor-P}CCKLR-17D3KG01373; ry506
VDRC	v102039 P{KK110484}VIE-260B v1815 w1118; P{GD731}v1815 v9154 w1118; P{GD3431}v9154/TM3
Genomic Clones ( 1 )
	BACR14D22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP03677
Other clones	IP03777
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	165784 EK270360 IP01894
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030954 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32864
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CCKLR-17D3 CG6894 (McBride, 2001.3.16)
Source for database merge of	Source for merge of: CCKLR-17D3 anon-WO0170980.64 anon-WO0170980.65 (FlyBase, 1996-) Source for merge of: CCKLR-17D3 CG6881 (McBride, 2001.3.16)
Additional comments	Annotations CG6881, CG6894 merged as CG32540 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of CCKLR-17D3 anon-WO0170980.64 anon-WO0170980.65 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001103553 RefSeq (Proteins) • NP_001097023 DDBJ / EMBL / GenBank • AAF48879 AAP69665 AX128640 AX254497 AX254498 AY231149 DD177537 Entrez Gene - A searchable database of RefSeq genes. • 32864 UniProtKB/TrEMBL • Q7M3J6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • G protein-coupled receptor, rhodopsin-like (IPR000276) Gastrin receptor (IPR000314) Cholecystokinin receptor (IPR009126) GPCR, rhodopsin-like, 7TM (IPR017452)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0030954 DRSC - Results from RNAi screens. • FBgn0030954 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030954 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32540-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030954 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32864 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32864 modMine - Data generated by the modENCODE project. • FBgn0030954
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	anon-WO0131005.21   anon-WO0170980.64   anon-WO0170980.65   CCKLR-17D3 (Chen and Ganetzky, 2012, Japanese National Institute of Genetics, 2012.5.21) CG6861 (Vanden Broeck, 2001) CG6881 (Kubiak et al., 2002, Hewes and Taghert, 2001.7.31, Hewes and Taghert, 2001, ) CG6894 (Kubiak et al., 2002, Vanden Broeck, 2001, Hewes and Taghert, 2001, ) CG32540 (Keleman et al., 2009.8.5, Perkins et al., 2009, Metpally and Sowdhamini, 2005) DSK-R1 (Kubiak et al., 2002) unnamed (McBride et al., 2001)
Name Synonym	CCK-like receptor at 17D3 (McBride, 2001.3.16) DSK-receptor2 (Veenstra et al., 2008)
Secondary FlyBase IDs
	FBgn0030953 FBgn0044361 FBgn0046518 FBgn0046519 FBgn0052540
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 2 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Patent  ( 2 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 1 )
	Chen and Ganetzky, 2012, J. Cell Biol. 196(4): 529--543 A neuropeptide signaling pathway regulates synaptic growth in Drosophila. [FBrf0217500] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...