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Gene Dmel\CG6891

General Information
Symbol	Dmel\CG6891	Species	D. melanogaster
Name		Annotation symbol	CG6891
Feature type	protein_coding_gene	FlyBase ID	FBgn0030955
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	17D4-17D5	Sequence location	X:18,669,263..18,675,378 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6891 (FBgn0030955). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: actin binding. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Actin-binding, cofilin/tropomyosin type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval midgut, larval hindgut, larval/adult Malpighian tubules, larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult midgut, adult hindgut, adult heart, larval/adult salivary gland, larval trachea, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1628314_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG6891. Gene sequence location is X:18669263..18675378.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN28899 HFA20016
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 17D4-17D5   Limits computationally determined from genome sequence between P{EP}EP443EP443&P{EP}BxEP1383 and P{EP}Pk17EEP438
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6891 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6891-RA FBtr0074631  NM_133095   992   163 CG6891-RB FBtr0074632  NM_167630   736   146
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6891-PA   FBpp0074402   18.6   163   4.61     NP_573323   AAF48881 CG6891-PB   FBpp0074403   16.6   146   4.63     NP_728196   AAN09475
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Actin-binding, cofilin/tropomyosin type (IPR002108)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48881   AE014298 AAN09475   AI260509   AI295342   AI296852   AI534384   AW944108   AY122215 AAM52727   BG637442   BH214645   BI163502   BI169586   BI170299   BI236859   BI241700   BI486504   BI581269   BI616478   BI633536   BI635114   BI637678   BP553541   BP553542   BP560282   BP560283   BT044342   CA803904   CA806704   CK657137   CK658058   CK659096   CK659124   CK659488   CK662180   CO184447   CO194834   CO281856   CO283140   CO318641   CO330898   CO338529   EC062330   EC203537   EC204443   EC245687   EC250171   EC250243   EC268022   EV578950   EV590529   EV599588   GH748909   GH750972   GH751959   GH753692   GH757900   GH758420   GH770305   GH770502   GH771023   GH771761   GH772277   GH772717   GH773756   GH776518   GH776925   GH778853   GH782380   GH782948   GH786016   GH787619   GH787662   GH789420   GH790137   GH791717   GH792815   GH793075   GH793479   GH794978   GH796311   GH796332   GH796477   GH796743   GH799423   GH799885   GH801799   GH802272   GH802429   GH803554   GH804153   GH804178   GH804314   GH805991   GH805997   GH806880   GH811737   GH812404   GH813326   GH813543   GH814664   GH815191   GH823467   GH825285   GH826077   GH827829   GH828076   GH829961   GH837209   GH838153   GH839545   GH840921   GH841444   GH843527   GH844147   GH844725   GH845736   GH846023   GH846284   GH848552   GH851669   GH856160   GH856368   GH856737   GH857109   GH857589   GH861141   GH862114   GH862206   GH862279   GH862559   GH862657   GH863058   GH863308   GH865514   GH865682   GH866264   GH866783   GH868818   GH868828   GH871469   GH871567   GH872792   GH873432   GH873573   GH877088   GH877704   GH879865   GH880224   GH880523   GH880655   GH882121   GH882490   GH883787   GH885433   GH887902   GH888143   GH891565   GH894030   GH894567   GH896175   GH896363   GH896444   GH897505   GH897840   GH898141   GH899851   GH901121   GH901272   GH901888   GH903241   GH904535   GH906037   GH906118   GH906137   GH908580   GH910550   GH911870   GH916736   GH917235   GH917351   GH918029   GH919999   GH920025   GH921395   GH921499   GH921800   GH921974   GH922067   GH923048   GH924207   GH928063   GH928259   GH931401   GH931810   GH935477   GH937803   GH938640   GH939740   GH940472
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IQX5 Q8MQZ6 Q9VWQ7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030955    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030955 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030955 expression level Developmental Stage   Expression Level embryo 00-02hr    237 embryo 02-04hr    811 embryo 04-06hr    1806 embryo 06-08hr    6818 embryo 08-10hr    12518 embryo 10-12hr    20996 embryo 12-14hr    12577 embryo 14-16hr    8778 embryo 16-18hr    4089 embryo 18-20hr    3262 embryo 20-22hr    2725 embryo 22-24hr    2896 larva L1    3241 larva L2    4784 larva L3 12hr old    5441 larva L3 puffstage 1-2    13213 larva L3 puffstage 3-6    21881 larva L3 puffstage 7-9    42117 white prepupae new    63544 white prepupae 12hr    72683 white prepupae 24hr    27753 pupae 2d postWPP    13556 pupae 3d postWPP    6463 pupae 4d postWPP    13367 adult male 01day    3636 adult male 05day    3311 adult male 30day    3094 adult female 01day    4944 adult female 05day    2947 adult female 30day    3198 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (237) embryo 02-04hr  (811) embryo 04-06hr  (1806) embryo 06-08hr  (6818) embryo 08-10hr  (12518) embryo 10-12hr  (20996) embryo 12-14hr  (12577) embryo 14-16hr  (8778) embryo 16-18hr  (4089) embryo 18-20hr  (3262) embryo 20-22hr  (2725) embryo 22-24hr  (2896) larva L1  (3241) larva L2  (4784) larva L3 12hr old  (5441) larva L3 puffstage 1-2  (13213) larva L3 puffstage 3-6  (21881) larva L3 puffstage 7-9  (42117) white prepupae new  (63544) white prepupae 12hr  (72683) white prepupae 24hr  (27753) pupae 2d postWPP  (13556) pupae 3d postWPP  (6463) pupae 4d postWPP  (13367) adult male 01day  (3636) adult male 05day  (3311) adult male 30day  (3094) adult female 01day  (4944) adult female 05day  (2947) adult female 30day  (3198) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    237 embryo 02-04hr    811 embryo 04-06hr  (1806) embryo 06-08hr  (6818) embryo 08-10hr  (12518) embryo 10-12hr  (20996) embryo 12-14hr  (12577) embryo 14-16hr  (8778) embryo 16-18hr  (4089) embryo 18-20hr  (3262) embryo 20-22hr  (2725) embryo 22-24hr  (2896) larva L1  (3241) larva L2  (4784) larva L3 12hr old  (5441) larva L3 puffstage 1-2  (13213) larva L3 puffstage 3-6  (21881) larva L3 puffstage 7-9  (42117) white prepupae new  (63544) white prepupae 12hr  (72683) white prepupae 24hr  (27753) pupae 2d postWPP  (13556) pupae 3d postWPP  (6463) pupae 4d postWPP  (13367) adult male 01day  (3636) adult male 05day  (3311) adult male 30day  (3094) adult female 01day  (4944) adult female 05day  (2947) adult female 30day  (3198) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    237 embryo 02-04hr    811 embryo 04-06hr    1806 embryo 06-08hr    6818 embryo 08-10hr  (12518) embryo 10-12hr  (20996) embryo 12-14hr  (12577) embryo 14-16hr    8778 embryo 16-18hr    4089 embryo 18-20hr    3262 embryo 20-22hr    2725 embryo 22-24hr    2896 larva L1    3241 larva L2    4784 larva L3 12hr old    5441 larva L3 puffstage 1-2  (13213) larva L3 puffstage 3-6  (21881) larva L3 puffstage 7-9  (42117) white prepupae new  (63544) white prepupae 12hr  (72683) white prepupae 24hr  (27753) pupae 2d postWPP  (13556) pupae 3d postWPP    6463 pupae 4d postWPP  (13367) adult male 01day    3636 adult male 05day    3311 adult male 30day    3094 adult female 01day    4944 adult female 05day    2947 adult female 30day    3198 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    237 embryo 02-04hr    811 embryo 04-06hr    1806 embryo 06-08hr    6818 embryo 08-10hr    12518 embryo 10-12hr    20996 embryo 12-14hr    12577 embryo 14-16hr    8778 embryo 16-18hr    4089 embryo 18-20hr    3262 embryo 20-22hr    2725 embryo 22-24hr    2896 larva L1    3241 larva L2    4784 larva L3 12hr old    5441 larva L3 puffstage 1-2    13213 larva L3 puffstage 3-6    21881 larva L3 puffstage 7-9    42117 white prepupae new    63544 white prepupae 12hr    72683 white prepupae 24hr    27753 pupae 2d postWPP    13556 pupae 3d postWPP    6463 pupae 4d postWPP    13367 adult male 01day    3636 adult male 05day    3311 adult male 30day    3094 adult female 01day    4944 adult female 05day    2947 adult female 30day    3198 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030955 expression level Developmental Stage   Expression Level embryo 00-02hr    237 embryo 02-04hr    811 embryo 04-06hr    1806 embryo 06-08hr    6818 embryo 08-10hr    12518 embryo 10-12hr    20996 embryo 12-14hr    12577 embryo 14-16hr    8778 embryo 16-18hr    4089 embryo 18-20hr    3262 embryo 20-22hr    2725 embryo 22-24hr    2896 larva L1    3241 larva L2    4784 larva L3 12hr old    5441 larva L3 puffstage 1-2    13213 larva L3 puffstage 3-6    21881 larva L3 puffstage 7-9    42117 white prepupae new    63544 white prepupae 12hr    72683 white prepupae 24hr    27753 pupae 2d postWPP    13556 pupae 3d postWPP    6463 pupae 4d postWPP    13367 adult male 01day    3636 adult male 05day    3311 adult male 30day    3094 adult female 01day    4944 adult female 05day    2947 adult female 30day    3198 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (237) embryo 02-04hr  (811) embryo 04-06hr  (1806) embryo 06-08hr  (6818) embryo 08-10hr  (12518) embryo 10-12hr  (20996) embryo 12-14hr  (12577) embryo 14-16hr  (8778) embryo 16-18hr  (4089) embryo 18-20hr  (3262) embryo 20-22hr  (2725) embryo 22-24hr  (2896) larva L1  (3241) larva L2  (4784) larva L3 12hr old  (5441) larva L3 puffstage 1-2  (13213) larva L3 puffstage 3-6  (21881) larva L3 puffstage 7-9  (42117) white prepupae new  (63544) white prepupae 12hr  (72683) white prepupae 24hr  (27753) pupae 2d postWPP  (13556) pupae 3d postWPP  (6463) pupae 4d postWPP  (13367) adult male 01day  (3636) adult male 05day  (3311) adult male 30day  (3094) adult female 01day  (4944) adult female 05day  (2947) adult female 30day  (3198) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    237 embryo 02-04hr    811 embryo 04-06hr  1806 embryo 06-08hr  (6818) embryo 08-10hr  (12518) embryo 10-12hr  (20996) embryo 12-14hr  (12577) embryo 14-16hr  (8778) embryo 16-18hr  (4089) embryo 18-20hr  (3262) embryo 20-22hr  (2725) embryo 22-24hr  (2896) larva L1  (3241) larva L2  (4784) larva L3 12hr old  (5441) larva L3 puffstage 1-2  (13213) larva L3 puffstage 3-6  (21881) larva L3 puffstage 7-9  (42117) white prepupae new  (63544) white prepupae 12hr  (72683) white prepupae 24hr  (27753) pupae 2d postWPP  (13556) pupae 3d postWPP  (6463) pupae 4d postWPP  (13367) adult male 01day  (3636) adult male 05day  (3311) adult male 30day  (3094) adult female 01day  (4944) adult female 05day  (2947) adult female 30day  (3198) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    237 embryo 02-04hr    811 embryo 04-06hr    1806 embryo 06-08hr    6818 embryo 08-10hr  12518 embryo 10-12hr  (20996) embryo 12-14hr  12577 embryo 14-16hr    8778 embryo 16-18hr    4089 embryo 18-20hr    3262 embryo 20-22hr    2725 embryo 22-24hr    2896 larva L1    3241 larva L2    4784 larva L3 12hr old    5441 larva L3 puffstage 1-2  13213 larva L3 puffstage 3-6  (21881) larva L3 puffstage 7-9  (42117) white prepupae new  (63544) white prepupae 12hr  (72683) white prepupae 24hr  (27753) pupae 2d postWPP  13556 pupae 3d postWPP    6463 pupae 4d postWPP  13367 adult male 01day    3636 adult male 05day    3311 adult male 30day    3094 adult female 01day    4944 adult female 05day    2947 adult female 30day    3198 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    237 embryo 02-04hr    811 embryo 04-06hr    1806 embryo 06-08hr    6818 embryo 08-10hr    12518 embryo 10-12hr    20996 embryo 12-14hr    12577 embryo 14-16hr    8778 embryo 16-18hr    4089 embryo 18-20hr    3262 embryo 20-22hr    2725 embryo 22-24hr    2896 larva L1    3241 larva L2    4784 larva L3 12hr old    5441 larva L3 puffstage 1-2    13213 larva L3 puffstage 3-6    21881 larva L3 puffstage 7-9    42117 white prepupae new    63544 white prepupae 12hr    72683 white prepupae 24hr    27753 pupae 2d postWPP    13556 pupae 3d postWPP    6463 pupae 4d postWPP    13367 adult male 01day    3636 adult male 05day    3311 adult male 30day    3094 adult female 01day    4944 adult female 05day    2947 adult female 30day    3198 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030955    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030955 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval midgut, larval hindgut, larval/adult Malpighian tubules, larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult midgut, adult hindgut, adult heart, larval/adult salivary gland, larval trachea, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030955 expression level Tissue   Expression Level Larval Central Nervous System    138.9 Larval Midgut    1321.5 Larval Hindgut    908.9 Larval Malpighian Tubules    1692.8 Larval Fat Body    514.1 Larval Salivary Gland    355.7 Larval Trachea    266.675 Larval Carcass    311.95 Adult Head no informative data Adult Eye    10.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    61.4 Adult Midgut    370.3 Adult Hindgut    338.6 Adult Malpighian Tubules    1998.1 Adult Fat Body no informative data Adult Salivary Gland    198.9 Adult Heart    111.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    47.7 Adult Testis    94.9 Adult Male Accessory Gland    51.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    138.9 Larval Midgut  (1321.5) Larval Hindgut  (908.9) Larval Malpighian Tubules  (1692.8) Larval Fat Body  514.1 Larval Salivary Gland    355.7 Larval Trachea    266.675 Larval Carcass    311.95 Adult Head no informative data Adult Eye    10.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    61.4 Adult Midgut    370.3 Adult Hindgut    338.6 Adult Malpighian Tubules  (1998.1) Adult Fat Body no informative data Adult Salivary Gland    198.9 Adult Heart    111.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    47.7 Adult Testis    94.9 Adult Male Accessory Gland    51.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    138.9 Larval Midgut  (1321.5) Larval Hindgut    908.9 Larval Malpighian Tubules  (1692.8) Larval Fat Body    514.1 Larval Salivary Gland    355.7 Larval Trachea    266.675 Larval Carcass    311.95 Adult Head no informative data Adult Eye    10.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    61.4 Adult Midgut    370.3 Adult Hindgut    338.6 Adult Malpighian Tubules  (1998.1) Adult Fat Body no informative data Adult Salivary Gland    198.9 Adult Heart    111.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    47.7 Adult Testis    94.9 Adult Male Accessory Gland    51.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    138.9 Larval Midgut    1321.5 Larval Hindgut    908.9 Larval Malpighian Tubules    1692.8 Larval Fat Body    514.1 Larval Salivary Gland    355.7 Larval Trachea    266.675 Larval Carcass    311.95 Adult Head no informative data Adult Eye    10.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    61.4 Adult Midgut    370.3 Adult Hindgut    338.6 Adult Malpighian Tubules    1998.1 Adult Fat Body no informative data Adult Salivary Gland    198.9 Adult Heart    111.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    47.7 Adult Testis    94.9 Adult Male Accessory Gland    51.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030955 expression level Tissue   Expression Level Larval Central Nervous System    138.9 Larval Midgut    1321.5 Larval Hindgut    908.9 Larval Malpighian Tubules    1692.8 Larval Fat Body    514.1 Larval Salivary Gland    355.7 Larval Trachea    266.675 Larval Carcass    311.95 Adult Head no informative data Adult Eye    10.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    61.4 Adult Midgut    370.3 Adult Hindgut    338.6 Adult Malpighian Tubules    1998.1 Adult Fat Body no informative data Adult Salivary Gland    198.9 Adult Heart    111.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    47.7 Adult Testis    94.9 Adult Male Accessory Gland    51.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    138.9 Larval Midgut  (1321.5) Larval Hindgut  (908.9) Larval Malpighian Tubules  (1692.8) Larval Fat Body  514.1 Larval Salivary Gland    355.7 Larval Trachea    266.675 Larval Carcass    311.95 Adult Head no informative data Adult Eye    10.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    61.4 Adult Midgut    370.3 Adult Hindgut    338.6 Adult Malpighian Tubules  (1998.1) Adult Fat Body no informative data Adult Salivary Gland    198.9 Adult Heart    111.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    47.7 Adult Testis    94.9 Adult Male Accessory Gland    51.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    138.9 Larval Midgut  1321.5 Larval Hindgut    908.9 Larval Malpighian Tubules  1692.8 Larval Fat Body    514.1 Larval Salivary Gland    355.7 Larval Trachea    266.675 Larval Carcass    311.95 Adult Head no informative data Adult Eye    10.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    61.4 Adult Midgut    370.3 Adult Hindgut    338.6 Adult Malpighian Tubules  (1998.1) Adult Fat Body no informative data Adult Salivary Gland    198.9 Adult Heart    111.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    47.7 Adult Testis    94.9 Adult Male Accessory Gland    51.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    138.9 Larval Midgut    1321.5 Larval Hindgut    908.9 Larval Malpighian Tubules    1692.8 Larval Fat Body    514.1 Larval Salivary Gland    355.7 Larval Trachea    266.675 Larval Carcass    311.95 Adult Head no informative data Adult Eye    10.325 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    61.4 Adult Midgut    370.3 Adult Hindgut    338.6 Adult Malpighian Tubules    1998.1 Adult Fat Body no informative data Adult Salivary Gland    198.9 Adult Heart    111.075 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    47.7 Adult Testis    94.9 Adult Male Accessory Gland    51.7 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    10.325   NA  Brain    no informative data   138.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    61.4   1321.5  Midgut    370.3   908.9  Hindgut    338.6   1692.8  Malpighian Tubules    1998.1   514.1  Fat Body    no informative data   355.7  Salivary Gland    198.9   NA  Heart    111.075   266.675  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    47.7   NA  Testis    94.9   NA  Male Accessory Gland    51.7   311.95  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030955 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6891-RA;CG6900-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG6891GD17294 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG6891 Class Mutagen Stocks Known lesion CG6891KG03306 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6891 Class Mutagen Stocks Known lesion CG6891GD17294 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG6891GD10758 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG6891KK108899 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel7464 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10758} NA P{GD13712} NA P{GD17294} NA P{KK108899} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}CG6891KG03306 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
actin binding inferred from electronic annotation with InterPro:IPR002108 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR002108 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6891 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59176 DroID - A comprehensive database of gene and protein interactions. • FBgn0030955 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32865
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19083 Dere\GG19183 Dgri\GH12531 Dmoj\GI11191 Dper\GL26993 Dpse\GA19933 Dsec\GM22913 Dsim\GD17404 Dvir\GJ18476 Dwil\GK10196 Dyak\GE17746
Curated drosophilid orthologs	Dpse\GA19933
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009467-PA Aedes aegypti (mosquito) AGAP000889-PA Anopheles gambiae (mosquito) 89530 Batrachochytrium dendrobatidis (chytrid fungus) 116725 Branchiostoma floridae (lancelet) ENSBTAP00000021704 Bos taurus (bovine) ENSCAFP00000029551 Canis familiaris (dog) cn02482 Cryptococcus neoformans (yeast-like fungus) CPIJ019500 Culex pipens (mosquito) ENSCPOP00000012244 Cavia porcellus (guinea pig) 159358 Capitella spl (polychaete worm) DDB0215369 Dictyostelium discoideum (amoeba) 308455 Daphnia pulex (daphnia) ENSDARP00000037758 Danio rerio (zebra fish) ENSECAP00000010534 Equus caballus (horse) XP_650926 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000000612 Gymnopilus aculeatus (mushroom) ENSGALP00000028283 Gallus gallus (chicken) 98567 Hypsipyla robusta (cedar shoot borer) ENSP00000262428 Homo sapiens (human) ISCW023736-PA Ixodes scapularis (deer tick) 203293 Lottia gigantea (owl limpet) ENSMODP00000005866 Monodelphis domestica (gray opossum) ENSMMUP00000009234 Macaca mulatta (rhesus monkey) ENSMUSP00000034285 Mus musculus (house mouse) 170922 Nematostella vectensis (starlet anemone) ENSOANP00000017973 Ornithorynchus anatinus (platypus) ENSORLP00000019348 Oryzias latipes (japanese killifish) ENSPPYP00000008584 Pongo pygmaeus (orangutan) ENSRNOP00000021954 Rattus norvegicus (norway rat) ENSTNIP00000011682 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000017309 Takifugu rubripes (pufferfish Takifugu) 85357.m00066 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000029195 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW023736 FBgn0235192 FBgn0212211 FBgn0205635 FBgn0188960 FBgn0177782 JGI_V11_308455 FBgn0079929 FBgn0164574 FBgn0133952 FBgn0030958 FBgn0120010 FBgn0111389 FBgn0096095 CPIJ019500 BGIBMGA014214 AGAP000889 AAEL009467
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	12888 y1 P{SUPor-P}CG6891KG03306
VDRC	v50054 w1118; P{GD17294}v50054 v50055 w1118; P{GD17294}v50055/CyO
Genomic Clones ( 1 )
	BACR14D22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 190 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP08941
Other clones	FI07634
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP04407 LP10951 LP14585 LP16585 LP16651 LP17284 LP22195 LP23196 RE02920 RE10807 RE11704 RE32983 RE38829 RE69941 RH18639 RH46438 SD07189 SD15446 SD16356 SD19737 SD27651
Other clones	51684 147662 172787 173973 572762 Dmel_dig_018533_0636_1014 Dmel_neb_007466_0420_3271 Dmel_neb_010558_0853_0972 EC28107 EC39296 EK158936 EK162335 EK273258 EK296407 EN17024 ESG014c.E21_H01 ESG0111a.B21_G06 FGM225A02 FGM325F09 RP003008749 RP003019029 RP003019599 RP003027183 RP003028933 RP003030442 RP003030483 RP003041164 RP003042376 RP003051080 RP003052591 RP003065565 RP003071434 RP003071832 RP003080856 RP003083616 RP003084427 RP003087759 RP003091141 RP003091490 RP003101346 RP003108513 RP003110944 RP003111086 RP003112482 RP003113140 RP003113581 RP003119308 RP003125375 RP003130379 RP003131912 RP003146624 RP003151531 RP003154421 RP003157569 RP003157860 RP003160026 RP003161461 RP003171110 RP003172597 RP003173776 RP003174479 RP003186980 RP003187005 RP003187180 RP003190853 RP003198538 RP003205254 RP003205435 RP003208485 RP003210453 RP003215771 RP003242677 RP003242827 RP003251361 RP003253257 RP003256994 RP003263313 RP003273581 RP003276330 RP003278063 RP003279310 RP003288432 RP003288732 RP003291190 RP003292229 RP003295429 RP003296555 RP003297860 RP003305988 RP003311773 RP003316510 RP003318506 RP003319605 RP003320196 RP003321449 RP003323655 RP003324853 RP003329417 RP003334492 RP003336442 RP003336684 RP003346185 RP003348076 RP003355578 RP003366834 RP003410109 RP003411085 RP003413495 RP003414530 RP003416568 RP003421367 RP003429962 RP003444513 RP003448078 RP003452849 RP003465210 RP003469364 RP003472322 RP003476426 RP003484450 RP003487734 RP003489200 RP003493796 RP003501525 RP003512316 RP003517684 RP003524288 RP003525092 RP003531815 RP003533634 RP003533962 RP003542449 RP003543252 RP003548960 RP003553107 RP003559235 RP003569720 RP003572826 RP003573519 RP003575563 RP003575968 RP003576294 RP003579155 RP003580089 RP003588157 RP003594367 RP003595829 RP003605386 RP003614861 RP003614886 RP003619678 RP003621087 RP003622959 RP003623150 RP003630378 RP003630846 RP003633444 RP003645888 RP003651243 RP003656620 RP003657199 RP003660721 RP003662499 RP003665639 RP003674157 RP003678964 RP003679210
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030955 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32865
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_133095 NM_167630 RefSeq (Proteins) • NP_573323 NP_728196 DDBJ / EMBL / GenBank • AAF48881 AAM52727 AAN09475 AI295342 AW944108 AY122215 BH214645 Entrez Gene - A searchable database of RefSeq genes. • 32865 UniProtKB/TrEMBL • Q8IQX5 Q8MQZ6 Q9VWQ7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Actin-binding, cofilin/tropomyosin type (IPR002108)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59176 DroID - A comprehensive database of gene and protein interactions. • FBgn0030955 DRSC - Results from RNAi screens. • FBgn0030955 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030955 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6891-RA;CG6900-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030955 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32865 InParanoid A subset of ortholog calls from InParanoid. • AAEL009467-PA Aedes aegypti (mosquito) AGAP000889-PA Anopheles gambiae (mosquito) 89530 Batrachochytrium dendrobatidis (chytrid fungus) 116725 Branchiostoma floridae (lancelet) ENSBTAP00000021704 Bos taurus (bovine) ENSCAFP00000029551 Canis familiaris (dog) cn02482 Cryptococcus neoformans (yeast-like fungus) CPIJ019500 Culex pipens (mosquito) ENSCPOP00000012244 Cavia porcellus (guinea pig) 159358 Capitella spl (polychaete worm) DDB0215369 Dictyostelium discoideum (amoeba) 308455 Daphnia pulex (daphnia) ENSDARP00000037758 Danio rerio (zebra fish) ENSECAP00000010534 Equus caballus (horse) XP_650926 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000000612 Gymnopilus aculeatus (mushroom) ENSGALP00000028283 Gallus gallus (chicken) 98567 Hypsipyla robusta (cedar shoot borer) ENSP00000262428 Homo sapiens (human) ISCW023736-PA Ixodes scapularis (deer tick) 203293 Lottia gigantea (owl limpet) ENSMODP00000005866 Monodelphis domestica (gray opossum) ENSMMUP00000009234 Macaca mulatta (rhesus monkey) ENSMUSP00000034285 Mus musculus (house mouse) 170922 Nematostella vectensis (starlet anemone) ENSOANP00000017973 Ornithorynchus anatinus (platypus) ENSORLP00000019348 Oryzias latipes (japanese killifish) ENSPPYP00000008584 Pongo pygmaeus (orangutan) ENSRNOP00000021954 Rattus norvegicus (norway rat) ENSTNIP00000011682 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000017309 Takifugu rubripes (pufferfish Takifugu) 85357.m00066 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000029195 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32865 modMine - Data generated by the modENCODE project. • FBgn0030955 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW023736 FBgn0235192 FBgn0212211 FBgn0205635 FBgn0188960 FBgn0177782 JGI_V11_308455 FBgn0079929 FBgn0164574 FBgn0133952 FBgn0030958 FBgn0120010 FBgn0111389 FBgn0096095 CPIJ019500 BGIBMGA014214 AGAP000889 AAEL009467
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG6891 (Zhan et al., 2011, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 15 )
Research paper	Zhan et al., 2011, Gene 470(1-2): 1--6 Evolution of alternative splicing in newly evolved genes of Drosophila. [FBrf0212278] de Morais Guedes et al., 2003, Biochem. biophys. Res. Commun. 312(3): 545--554 Drosophila melanogaster larval hemolymph protein mapping. [FBrf0167337]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Kodira, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126678]