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Gene Dmel\Pvf1

General Information
Symbol	Dmel\Pvf1	Species	D. melanogaster
Name	PDGF- and VEGF-related factor 1	Annotation symbol	CG7103
Feature type	protein_coding_gene	FlyBase ID	FBgn0030964
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	PVF, Vegf17E, VEGF
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	17E1-17E1	Sequence location	X:18,726,736..18,736,934 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene PDGF- and VEGF-related factor 1 is referred to in FlyBase by the symbol Dmel\Pvf1 (CG7103, FBgn0030964). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: heparin binding; receptor binding. There is experimental evidence that it is involved in the biological process: Malpighian tubule morphogenesis; border follicle cell migration; cell projection assembly; hemocyte migration; salivary gland morphogenesis. 22 alleles are reported. The phenotypes of these alleles are annotated with: ejaculatory bulb; embryonic anterior Malpighian tubule; male terminalia; intersegmental nerve; border follicle cell; embryonic dorsal epidermis. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Platelet-derived growth factor (PDGF). Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult midgut, adult hindgut, larval/adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1631638_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Pvf1. Gene sequence location is X:18726736..18736934.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN32211 HFA20024
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 17E1-17E1   Limits computationally determined from genome sequence between P{EP}EP1597 and P{EP}Pvf1EP1624
Experimentally Determined Cytological Location
Cytogenetic map Notes References 17E-17E   (determined by in situ hybridisation)   (Peter et al., 2002) 17E1-17E2     (Roos, 2000.7.19) 17E-17E   (determined by in situ hybridisation)   (Schaefer et al., 1999.12.14)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pvf1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pvf1-RA FBtr0074640  NM_078683   1874   325 Pvf1-RB FBtr0301667  NM_001169321   1783   314
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pvf1-PA   FBpp0074411   35.8   325   7.02     NP_523407   AAF48892 Pvf1-PB   FBpp0290881   34.5   314   5.81     NP_001162792   ACZ95326
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Platelet-derived growth factor (PDGF) (IPR000072)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA950267   AA950511   AE014298 AAF48892   AE014298 ACZ95326   AI457004   AJ401391 CAC24699   AJ426989   AQ254783   AW942906   AY051751 AAK93175   AY079186 AAL91091   AY079188 AAL91093   BG638593   BG638825   BI161833   BI161834   BI170927   BI171442   BI373601   BP541219   BP541220   CO188171   CO188560   CO275129   CO289730   CO301394   CO305144   CO315472   CO316588   CO344028   CZ482352   CZ482353   CZ484832   EC054220   EC057660   EC065798   EC066385   EC067535   EC076896   EC195267   EC197044   EC198229   EC211591   EC238510   EC242214   EC248803   GH749512   GH752624   GH756004   GH758021   GH760719   GH777265   GH777890   GH779938   GH780318   GH780479   GH781873   GH783589   GH783828   GH785926   GH800423   GH801053   GH807155   GH810558   GH811090   GH811510   GH813969   GH814915   GH816382   GH820375   GH821300   GH823710   GH827161   GH828576   GH828862   GH829977   GH829982   GH832828   GH834987   GH839598   GH841247   GH847547   GH851819   GH856438   GH858392   GH858769   GH862927   GH864468   GH864838   GH865186   GH866669   GH870411   GH871285   GH871628   GH873364   GH875190   GH876272   GH876407   GH878200   GH878700   GH885716   GH888518   GH888993   GH889259   GH889410   GH892749   GH893358   GH898331   GH901374   GH906558   GH907077   GH910951   GH911463   GH911633   GH913753   GH915683   GH917159   GH918100   GH918991   GH921288   GH923389   GH924593   GH927171   GH929019   GH930884   GH933352   GH939471
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9BLX1 Q9VWP6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Heino et al., 2001) embryonic stage 10 -- 12   tracheal branch primordium   (Cho et al., 2002) embryonic stage 10 -- 15   posterior ectoderm | restricted   (Cho et al., 2002) presumptive embryonic salivary gland   (Cho et al., 2002) embryonic stage 13   tracheal branch primordium | restricted   (Cho et al., 2002) embryonic stage 13 -- 17   Malpighian tubule   (Cho et al., 2002) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism   (Heino et al., 2001) Comment:Expression is strongest in female adults and in early embryos.
Additional Descriptive Data
	In stage 10 embryos, expression was detected in an ectodermal patch at the caudal margin of the germband where hemocytes enter the tail. This expression continued through stage 12 and subsequently a posterior ring of ectodermal cells expressed transcript. Transcript was also detected in the salivary glands and developing trachea. Salivary gland expression persists through stage 15. General tracheal expression persisted through stage 12. During stage 13 tracheal expression was restricted to the tips of growing ganglionic branches and the visceral branches. (Cho et al., 2002)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage -- pupal stage   wing disc   • apical plasma membrane (Rosin et al., 2004) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030964    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030964 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030964 expression level Developmental Stage   Expression Level embryo 00-02hr    2118 embryo 02-04hr    803 embryo 04-06hr    215 embryo 06-08hr    354 embryo 08-10hr    906 embryo 10-12hr    1116 embryo 12-14hr    866 embryo 14-16hr    1482 embryo 16-18hr    2675 embryo 18-20hr    2910 embryo 20-22hr    827 embryo 22-24hr    725 larva L1    318 larva L2    290 larva L3 12hr old    294 larva L3 puffstage 1-2    214 larva L3 puffstage 3-6    419 larva L3 puffstage 7-9    963 white prepupae new    1511 white prepupae 12hr    1648 white prepupae 24hr    707 pupae 2d postWPP    720 pupae 3d postWPP    599 pupae 4d postWPP    950 adult male 01day    631 adult male 05day    846 adult male 30day    1176 adult female 01day    1411 adult female 05day    1678 adult female 30day    1705 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2118) embryo 02-04hr  (803) embryo 04-06hr  (215) embryo 06-08hr  (354) embryo 08-10hr  (906) embryo 10-12hr  (1116) embryo 12-14hr  (866) embryo 14-16hr  (1482) embryo 16-18hr  (2675) embryo 18-20hr  (2910) embryo 20-22hr  (827) embryo 22-24hr  (725) larva L1  (318) larva L2  (290) larva L3 12hr old  (294) larva L3 puffstage 1-2  (214) larva L3 puffstage 3-6  (419) larva L3 puffstage 7-9  (963) white prepupae new  (1511) white prepupae 12hr  (1648) white prepupae 24hr  (707) pupae 2d postWPP  (720) pupae 3d postWPP  (599) pupae 4d postWPP  (950) adult male 01day  (631) adult male 05day  (846) adult male 30day  (1176) adult female 01day  (1411) adult female 05day  (1678) adult female 30day  (1705) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2118) embryo 02-04hr    803 embryo 04-06hr    215 embryo 06-08hr    354 embryo 08-10hr    906 embryo 10-12hr    1116 embryo 12-14hr    866 embryo 14-16hr  1482 embryo 16-18hr  (2675) embryo 18-20hr  (2910) embryo 20-22hr    827 embryo 22-24hr    725 larva L1    318 larva L2    290 larva L3 12hr old    294 larva L3 puffstage 1-2    214 larva L3 puffstage 3-6    419 larva L3 puffstage 7-9    963 white prepupae new  (1511) white prepupae 12hr  (1648) white prepupae 24hr    707 pupae 2d postWPP    720 pupae 3d postWPP    599 pupae 4d postWPP    950 adult male 01day    631 adult male 05day    846 adult male 30day    1176 adult female 01day  1411 adult female 05day  (1678) adult female 30day  (1705) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2118 embryo 02-04hr    803 embryo 04-06hr    215 embryo 06-08hr    354 embryo 08-10hr    906 embryo 10-12hr    1116 embryo 12-14hr    866 embryo 14-16hr    1482 embryo 16-18hr    2675 embryo 18-20hr    2910 embryo 20-22hr    827 embryo 22-24hr    725 larva L1    318 larva L2    290 larva L3 12hr old    294 larva L3 puffstage 1-2    214 larva L3 puffstage 3-6    419 larva L3 puffstage 7-9    963 white prepupae new    1511 white prepupae 12hr    1648 white prepupae 24hr    707 pupae 2d postWPP    720 pupae 3d postWPP    599 pupae 4d postWPP    950 adult male 01day    631 adult male 05day    846 adult male 30day    1176 adult female 01day    1411 adult female 05day    1678 adult female 30day    1705 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2118 embryo 02-04hr    803 embryo 04-06hr    215 embryo 06-08hr    354 embryo 08-10hr    906 embryo 10-12hr    1116 embryo 12-14hr    866 embryo 14-16hr    1482 embryo 16-18hr    2675 embryo 18-20hr    2910 embryo 20-22hr    827 embryo 22-24hr    725 larva L1    318 larva L2    290 larva L3 12hr old    294 larva L3 puffstage 1-2    214 larva L3 puffstage 3-6    419 larva L3 puffstage 7-9    963 white prepupae new    1511 white prepupae 12hr    1648 white prepupae 24hr    707 pupae 2d postWPP    720 pupae 3d postWPP    599 pupae 4d postWPP    950 adult male 01day    631 adult male 05day    846 adult male 30day    1176 adult female 01day    1411 adult female 05day    1678 adult female 30day    1705 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030964 expression level Developmental Stage   Expression Level embryo 00-02hr    2118 embryo 02-04hr    803 embryo 04-06hr    215 embryo 06-08hr    354 embryo 08-10hr    906 embryo 10-12hr    1116 embryo 12-14hr    866 embryo 14-16hr    1482 embryo 16-18hr    2675 embryo 18-20hr    2910 embryo 20-22hr    827 embryo 22-24hr    725 larva L1    318 larva L2    290 larva L3 12hr old    294 larva L3 puffstage 1-2    214 larva L3 puffstage 3-6    419 larva L3 puffstage 7-9    963 white prepupae new    1511 white prepupae 12hr    1648 white prepupae 24hr    707 pupae 2d postWPP    720 pupae 3d postWPP    599 pupae 4d postWPP    950 adult male 01day    631 adult male 05day    846 adult male 30day    1176 adult female 01day    1411 adult female 05day    1678 adult female 30day    1705 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2118) embryo 02-04hr  (803) embryo 04-06hr  (215) embryo 06-08hr  (354) embryo 08-10hr  (906) embryo 10-12hr  (1116) embryo 12-14hr  (866) embryo 14-16hr  (1482) embryo 16-18hr  (2675) embryo 18-20hr  (2910) embryo 20-22hr  (827) embryo 22-24hr  (725) larva L1  (318) larva L2  (290) larva L3 12hr old  (294) larva L3 puffstage 1-2  (214) larva L3 puffstage 3-6  (419) larva L3 puffstage 7-9  (963) white prepupae new  (1511) white prepupae 12hr  (1648) white prepupae 24hr  (707) pupae 2d postWPP  (720) pupae 3d postWPP  (599) pupae 4d postWPP  (950) adult male 01day  (631) adult male 05day  (846) adult male 30day  (1176) adult female 01day  (1411) adult female 05day  (1678) adult female 30day  (1705) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2118 embryo 02-04hr    803 embryo 04-06hr    215 embryo 06-08hr    354 embryo 08-10hr    906 embryo 10-12hr    1116 embryo 12-14hr    866 embryo 14-16hr  1482 embryo 16-18hr  (2675) embryo 18-20hr  (2910) embryo 20-22hr    827 embryo 22-24hr    725 larva L1    318 larva L2    290 larva L3 12hr old    294 larva L3 puffstage 1-2    214 larva L3 puffstage 3-6    419 larva L3 puffstage 7-9    963 white prepupae new  1511 white prepupae 12hr  1648 white prepupae 24hr    707 pupae 2d postWPP    720 pupae 3d postWPP    599 pupae 4d postWPP    950 adult male 01day    631 adult male 05day    846 adult male 30day    1176 adult female 01day  1411 adult female 05day  1678 adult female 30day  1705 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2118 embryo 02-04hr    803 embryo 04-06hr    215 embryo 06-08hr    354 embryo 08-10hr    906 embryo 10-12hr    1116 embryo 12-14hr    866 embryo 14-16hr    1482 embryo 16-18hr    2675 embryo 18-20hr    2910 embryo 20-22hr    827 embryo 22-24hr    725 larva L1    318 larva L2    290 larva L3 12hr old    294 larva L3 puffstage 1-2    214 larva L3 puffstage 3-6    419 larva L3 puffstage 7-9    963 white prepupae new    1511 white prepupae 12hr    1648 white prepupae 24hr    707 pupae 2d postWPP    720 pupae 3d postWPP    599 pupae 4d postWPP    950 adult male 01day    631 adult male 05day    846 adult male 30day    1176 adult female 01day    1411 adult female 05day    1678 adult female 30day    1705 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2118 embryo 02-04hr    803 embryo 04-06hr    215 embryo 06-08hr    354 embryo 08-10hr    906 embryo 10-12hr    1116 embryo 12-14hr    866 embryo 14-16hr    1482 embryo 16-18hr    2675 embryo 18-20hr    2910 embryo 20-22hr    827 embryo 22-24hr    725 larva L1    318 larva L2    290 larva L3 12hr old    294 larva L3 puffstage 1-2    214 larva L3 puffstage 3-6    419 larva L3 puffstage 7-9    963 white prepupae new    1511 white prepupae 12hr    1648 white prepupae 24hr    707 pupae 2d postWPP    720 pupae 3d postWPP    599 pupae 4d postWPP    950 adult male 01day    631 adult male 05day    846 adult male 30day    1176 adult female 01day    1411 adult female 05day    1678 adult female 30day    1705 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030964    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030964 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult midgut, adult hindgut, larval/adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030964 expression level Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    51.8 Larval Hindgut    67.2 Larval Malpighian Tubules    265.4 Larval Fat Body no informative data Larval Salivary Gland    222.7 Larval Trachea    128.75 Larval Carcass    84.075 Adult Head    53.1 Adult Eye    25.325 Adult Brain    7.7 Adult Thoracic-Abdominal Ganglion    9.9 Adult Crop    146.2 Adult Midgut    166.9 Adult Hindgut    127.9 Adult Malpighian Tubules    310.8 Adult Fat Body    17.5 Adult Salivary Gland    1159.9 Adult Heart    10.75 Adult VirginFemale Spermatheca    38.6 Adult InseminatedFemale Spermatheca    45.8 Adult Ovary    254.2 Adult Testis    63.4 Adult Male Accessory Gland    520.4 Adult Carcass    58.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    51.8 Larval Hindgut    67.2 Larval Malpighian Tubules    265.4 Larval Fat Body no informative data Larval Salivary Gland    222.7 Larval Trachea    128.75 Larval Carcass    84.075 Adult Head    53.1 Adult Eye    25.325 Adult Brain    7.7 Adult Thoracic-Abdominal Ganglion    9.9 Adult Crop    146.2 Adult Midgut    166.9 Adult Hindgut    127.9 Adult Malpighian Tubules    310.8 Adult Fat Body    17.5 Adult Salivary Gland  (1159.9) Adult Heart    10.75 Adult VirginFemale Spermatheca    38.6 Adult InseminatedFemale Spermatheca    45.8 Adult Ovary    254.2 Adult Testis    63.4 Adult Male Accessory Gland  520.4 Adult Carcass    58.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    51.8 Larval Hindgut    67.2 Larval Malpighian Tubules    265.4 Larval Fat Body no informative data Larval Salivary Gland    222.7 Larval Trachea    128.75 Larval Carcass    84.075 Adult Head    53.1 Adult Eye    25.325 Adult Brain    7.7 Adult Thoracic-Abdominal Ganglion    9.9 Adult Crop    146.2 Adult Midgut    166.9 Adult Hindgut    127.9 Adult Malpighian Tubules    310.8 Adult Fat Body    17.5 Adult Salivary Gland  (1159.9) Adult Heart    10.75 Adult VirginFemale Spermatheca    38.6 Adult InseminatedFemale Spermatheca    45.8 Adult Ovary    254.2 Adult Testis    63.4 Adult Male Accessory Gland    520.4 Adult Carcass    58.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    51.8 Larval Hindgut    67.2 Larval Malpighian Tubules    265.4 Larval Fat Body no informative data Larval Salivary Gland    222.7 Larval Trachea    128.75 Larval Carcass    84.075 Adult Head    53.1 Adult Eye    25.325 Adult Brain    7.7 Adult Thoracic-Abdominal Ganglion    9.9 Adult Crop    146.2 Adult Midgut    166.9 Adult Hindgut    127.9 Adult Malpighian Tubules    310.8 Adult Fat Body    17.5 Adult Salivary Gland    1159.9 Adult Heart    10.75 Adult VirginFemale Spermatheca    38.6 Adult InseminatedFemale Spermatheca    45.8 Adult Ovary    254.2 Adult Testis    63.4 Adult Male Accessory Gland    520.4 Adult Carcass    58.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030964 expression level Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    51.8 Larval Hindgut    67.2 Larval Malpighian Tubules    265.4 Larval Fat Body no informative data Larval Salivary Gland    222.7 Larval Trachea    128.75 Larval Carcass    84.075 Adult Head    53.1 Adult Eye    25.325 Adult Brain    7.7 Adult Thoracic-Abdominal Ganglion    9.9 Adult Crop    146.2 Adult Midgut    166.9 Adult Hindgut    127.9 Adult Malpighian Tubules    310.8 Adult Fat Body    17.5 Adult Salivary Gland    1159.9 Adult Heart    10.75 Adult VirginFemale Spermatheca    38.6 Adult InseminatedFemale Spermatheca    45.8 Adult Ovary    254.2 Adult Testis    63.4 Adult Male Accessory Gland    520.4 Adult Carcass    58.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    51.8 Larval Hindgut    67.2 Larval Malpighian Tubules    265.4 Larval Fat Body no informative data Larval Salivary Gland    222.7 Larval Trachea    128.75 Larval Carcass    84.075 Adult Head    53.1 Adult Eye    25.325 Adult Brain    7.7 Adult Thoracic-Abdominal Ganglion    9.9 Adult Crop    146.2 Adult Midgut    166.9 Adult Hindgut    127.9 Adult Malpighian Tubules    310.8 Adult Fat Body    17.5 Adult Salivary Gland  (1159.9) Adult Heart    10.75 Adult VirginFemale Spermatheca    38.6 Adult InseminatedFemale Spermatheca    45.8 Adult Ovary    254.2 Adult Testis    63.4 Adult Male Accessory Gland  520.4 Adult Carcass    58.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    51.8 Larval Hindgut    67.2 Larval Malpighian Tubules    265.4 Larval Fat Body no informative data Larval Salivary Gland    222.7 Larval Trachea    128.75 Larval Carcass    84.075 Adult Head    53.1 Adult Eye    25.325 Adult Brain    7.7 Adult Thoracic-Abdominal Ganglion    9.9 Adult Crop    146.2 Adult Midgut    166.9 Adult Hindgut    127.9 Adult Malpighian Tubules    310.8 Adult Fat Body    17.5 Adult Salivary Gland  1159.9 Adult Heart    10.75 Adult VirginFemale Spermatheca    38.6 Adult InseminatedFemale Spermatheca    45.8 Adult Ovary    254.2 Adult Testis    63.4 Adult Male Accessory Gland    520.4 Adult Carcass    58.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.95 Larval Midgut    51.8 Larval Hindgut    67.2 Larval Malpighian Tubules    265.4 Larval Fat Body no informative data Larval Salivary Gland    222.7 Larval Trachea    128.75 Larval Carcass    84.075 Adult Head    53.1 Adult Eye    25.325 Adult Brain    7.7 Adult Thoracic-Abdominal Ganglion    9.9 Adult Crop    146.2 Adult Midgut    166.9 Adult Hindgut    127.9 Adult Malpighian Tubules    310.8 Adult Fat Body    17.5 Adult Salivary Gland    1159.9 Adult Heart    10.75 Adult VirginFemale Spermatheca    38.6 Adult InseminatedFemale Spermatheca    45.8 Adult Ovary    254.2 Adult Testis    63.4 Adult Male Accessory Gland    520.4 Adult Carcass    58.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    53.1   NA  Eye    25.325   NA  Brain    7.7   5.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    9.9   NA  Crop    146.2   51.8  Midgut    166.9   67.2  Hindgut    127.9   265.4  Malpighian Tubules    310.8   no informative data  Fat Body    17.5   222.7  Salivary Gland    1159.9   NA  Heart    10.75   128.75  Trachea    NA   NA  VirginFemale Spermatheca    38.6   NA  InseminatedFemale Spermatheca    45.8   NA  Ovary    254.2   NA  Testis    63.4   NA  Male Accessory Gland    520.4   84.075  Carcass    58.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030964 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7103-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Pvf1 Stages(s) 1-3 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage Pvf1EP1624 semi-lethal | recessive Pvf1G0146 viable, with Scer\GAL4[-]: Pvf1EP1624 viable, with Scer\GAL4pnr-MD237 Pvf1GD3432 Pvf1GD17185 viable | reduced, with Scer\GAL4[-]: Pvf1EP1624 Sterility Allele fertile | reduced, with Scer\GAL4[-]: Pvf1EP1624 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 Pvf1EP1624 wild-type, with Scer\GAL4dpp.blk1 Pvf1EPg11235 wild-type, with Scer\GAL4hh-Gal4 Pvf1EPg11235 Phenotype manifest in Allele adult external abdomen | dorsal Pvf1LP23semil1 anterior fascicle & synapse, with Scer\GAL4elav-C155 Pvf1EP1624 border follicle cell Pvf1EP1624 border follicle cell, with Scer\GAL4[-]: Pvf1EP1624 border follicle cell, with Scer\GAL4slbo.2.6 Pvf1EPg11235 Pvf1Scer\UAS.cMa border follicle cell & filopodium, with Scer\GAL4slbo.2.6 Pvf1EPg11235 border follicle cell | cell non-autonomous | somatic clone, with Scer\GAL4Act5C.PI Pvf1Scer\UAS.cMa border follicle cell | somatic clone, with Scer\GAL4cb41 Pvf1Scer\UAS.cMa border follicle cell | somatic clone, with Scer\GAL4slbo.2.6 Pvf1EPg11235 border follicle cell | somatic clone, with Scer\GAL4tub.PU Pvf1EPg11235 ejaculatory bulb Pvf1LP23semil1 ejaculatory bulb, with Scer\GAL4[-]: Pvf1EP1624 embryonic anterior Malpighian tubule Pvf1G0146 embryonic dorsal epidermis, with Scer\GAL4[-]: Pvf1EP1624 intersegmental nerve, with Scer\GAL4elav-C155 Pvf1EP1624 male terminalia Pvf1LP23semil1 male terminalia, with Scer\GAL4[-]: Pvf1EP1624 male terminalia, with Pvf1EPg11235, Scer\GAL4en-e16E Pvf1Scer\UAS.P\T.cRb male terminalia, with Pvf1EPg11235, Scer\GAL4hh-Gal4 Pvf1Scer\UAS.P\T.cRb male terminalia, with Pvf1Scer\UAS.P\T.cRb, Scer\GAL4en-e16E Pvf1EPg11235 male terminalia, with Pvf1Scer\UAS.P\T.cRb, Scer\GAL4hh-Gal4 Pvf1EPg11235 male terminalia, with Scer\GAL4en-e16E Pvf1EPg11235 male terminalia, with Scer\GAL4hh-Gal4 Pvf1EPg11235
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of Pvf1 Class Mutagen Stocks Known lesion Pvf1c05589 piggyBac transposase 1 Yes Pvf1e04594 piggyBac transposase 1 -- Pvf1EP1624 loss of function allele P-element activity 1 Yes Pvf1f02326 piggyBac transposase 1 -- Pvf1G0146 P-element activity 1 -- Pvf1MB01242 1 -- Pvf1d05686 P-element activity 0 Yes Pvf1EPg11235 P-element activity 0 -- Pvf1ex3.6 P-element activity 0 Yes Pvf1LP23semil1 Delta2-3 0 Yes Pvf1LP23semil2 Delta2-3 0 Yes Pvf1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pvf1 Class Mutagen Stocks Known lesion Pvf1GD3432 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Pvf1GD17185 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pvf1KK112211 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pvf1B.Scer\UAS in vitro construct - regulatory fusion 0 Yes Pvf1cFa in vitro construct 0 Yes Pvf1dsRNA.cCa in vitro construct - RNAi 0 Yes Pvf1Scer\UAS.cMa in vitro construct - regulatory fusion 0 Yes Pvf1Scer\UAS.cMb in vitro construct - regulatory fusion 0 Yes Pvf1Scer\UAS.cRa in vitro construct - regulatory fusion 0 Yes Pvf1Scer\UAS.P\T.cRb in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel7465 (Ryder, 2004.4.26) Df(1)LP23semil2 (Macias et al., 2004)
Duplicated in	Dp(1;3)DC353 (Popodi, 2010.10.8) Dp(1;Y)W39 (Macias et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3432} NA P{GD17185} NA P{KK112211} NA P{UASp2-Pvf1.Rb} NA P{UAS-Pvf1.B} NA P{UAS-Pvf1.M} NA P{UAS-Pvf1.Mb} NA P{UAS-Pvf1.R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP1597 NA P{EP}Pvf1EP1624 NA P{EPg}Pvf1EPg11235 NA P{XP}Pvf1d05686 NA miscellaneous insertions PBac{PB}Pvf1c05589 NA PBac{RB}Pvf1e04594 NA PBac{WH}Pvf1f02326 NA insertion of enhancer trap P{lacW}Pvf1G0146 No insertion of enhancer trap binary system Mi{ET1}Pvf1MB01242 No P{GawB}LP23 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
heparin binding inferred from direct assay (Rosin et al., 2004) receptor binding inferred from physical interaction with Pvr AND inferred from sequence or structural similarity with human PDGFA AND inferred from sequence or structural similarity with human PDGFB AND inferred from sequence or structural similarity with human VEGFA AND inferred from sequence or structural similarity with human VEGFB (Duchek et al., 2001)
Biological Process
CV term Evidence References
border follicle cell migration inferred from genetic interaction with tai AND inferred from mutant phenotype (McDonald et al., 2003) inferred from mutant phenotype (Duchek et al., 2001, McDonald et al., 2006, Mathieu et al., 2007) cell projection assembly inferred from mutant phenotype (Fulga and Rorth, 2002) hemocyte migration inferred from expression pattern (Cho et al., 2002) inferred from genetic interaction with Pvf2, Pvf3 (Cho et al., 2002) Malpighian tubule morphogenesis inferred from mutant phenotype (Bunt et al., 2010) salivary gland morphogenesis inferred from mutant phenotype (Harris et al., 2007)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Duchek et al., 2001)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
growth factor activity inferred from electronic annotation with InterPro:IPR000072 (FlyBase Curators et al., 2004-) vascular endothelial growth factor receptor binding inferred from sequence or structural similarity with human VEGFA (Cho et al., 2002) non-traceable author statement (Cho, 2002.2.19)
Biological Process
CV term Evidence References
border follicle cell migration traceable author statement (Ribeiro et al., 2003) hemocyte migration traceable author statement (Ribeiro et al., 2003) vascular endothelial growth factor receptor signaling pathway inferred from sequence or structural similarity with human VEGFA (Cho et al., 2002)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence or structural similarity with human PDGFA AND inferred from sequence or structural similarity with human VEGFA (Duchek et al., 2001) membrane inferred from electronic annotation with InterPro:IPR000072 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pvf1 allele Gene References Pvf1dsRNA.cCa Pvf3 (Cho et al., 2002) Pvf1EP1624 Egfr (Duchek et al., 2001) tai (McDonald et al., 2003) Pvf1EPg11235 Pvr (Duchek et al., 2001, Fulga and Rorth, 2002) Pvf1Scer\UAS.cMa tai (McDonald et al., 2003) Pvf1Scer\UAS.cRa Pvr (Rosin et al., 2004) unspecified hep (Mathieu et al., 2007) Pvf2 (Cho et al., 2002) Pvr (Macias et al., 2004) vn (Duchek et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59185 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030964 DroID - A comprehensive database of gene and protein interactions. • FBgn0030964 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32876
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19053 Dere\GG19190 Dgri\GH24520 Dmoj\GI15086 Dpse\GA20104 Dsim\GD17412 Dvir\GJ18893 Dwil\GK16524 Dyak\GE17753
Curated drosophilid orthologs	Dpse\GA20104
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013840-PA Aedes aegypti (mosquito) AGAP000574-PA Anopheles gambiae (mosquito) XP_392204.1 Apis mellifera (honey bee) XP_001950669.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000007026 Bos taurus (bovine) CE21657 Caenorhabditis elegans (worm) CPIJ012748 Culex pipens (mosquito) ENSECAP00000010054 Equus caballus (horse) ENSGACP00000021634 Gymnopilus aculeatus (mushroom) ISCW021859-PA Ixodes scapularis (deer tick) ENSMODP00000027011 Monodelphis domestica (gray opossum) ENSORLP00000002709 Oryzias latipes (japanese killifish) PHUM007028-PA Pediculus humanus (human body louse) XP_001184357.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001186746.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000006486 Tetraodon nigroviridis (green spotted pufferfish) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV23126 LH23674 ISCW021859 FBgn0235198 FBgn0218526 FBgn0206039 FBgn0188967 FBgn0177791 FBgn0177790 FBgn0173627 JGI_V11_98897 JGI_V11_308843 FBgn0080100 FBgn0137836 FBgn0131976 FBgn0111396 FBgn0096065 CPIJ012748 BGIBMGA001092 ACYPI53639 ACYPI32275 ACYPI24120 ACYPI008173 ACYPI007115 ACYPI006308 GB12643 AGAP000574 AAEL013840 PB20428 PHUM138740 GLEAN_07448
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	11450 w1118 P{EP}Pvf1EP1624 20364 w1118 PBac{PB}Pvf1c05589 23032 w1118 Mi{ET1}Pvf1MB01242 12286 w67c23 P{lacW}Pvf1G0146/FM7c
Harvard	- PBac{RB}Pvf1e04594 - PBac{WH}Pvf1f02326
VDRC	v102699 P{KK112211}VIE-260B v46875 w1118 P{GD17185}v46875 v6173 w1118; P{GD3432}v6173/TM3 v6175 w1118; P{GD3432}v6175/TM3
Genomic Clones ( 1 )
	BACR25O02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 112 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD28763
Other clones	DPiM_LD28763
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE12557 RE13221 RE60937
Other clones	14424 58382 119007 119151 125270 158606 161504 193331 CK01.39A.F12 CK01.48D.H7 CK01.88C.A10 CK01.92A.G1 EC054220 EK038056 EK040932 EK071925 EK116533 EK180856 EK247529 EK261560 EK265339 EP18540 FGA011F06 LD30334 LD37208 RE01324 RP003043362 RP003045057 RP003070748 RP003082731 RP003098014 RP003101795 RP003104665 RP003114567 RP003115334 RP003116736 RP003119193 RP003140617 RP003143112 RP003158735 RP003170640 RP003172224 RP003176723 RP003178024 RP003178952 RP003189749 RP003192122 RP003195478 RP003201651 RP003209732 RP003216182 RP003217929 RP003223152 RP003229635 RP003230773 RP003238945 RP003238994 RP003254619 RP003260404 RP003264632 RP003265772 RP003267336 RP003275432 RP003278543 RP003278723 RP003283489 RP003285092 RP003285342 RP003304291 RP003308926 RP003309138 RP003317915 RP003318521 RP003335155 RP003339045 RP003339390 RP003348249 RP003350929 RP003351064 RP003351098 RP003353788 RP003354209 RP003355256 RP003356745 RP003378506 RP003382190 RP003402974 RP003405071 RP003406374 RP003434432 RP003449919 RP003462569 RP003494707 RP003497406 RP003513745 RP003544918 RP003548730 RP003560012 RP003560715 RP003561095 RP003603808 RP003612504 RP003619125 RP003626875 RP003631269 RP003643766 RP003650032
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030964 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32876
Antibody Information
	polyclonal antibody, amino acids 27-303 (Pvf1-PA) (Rosin et al., 2004)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Pvf1 CG7103 (Rorth and Roos, 2001.8.16)
Source for database merge of	Source for merge of: Pvf1 l(1)G0146 (Peter et al., 2002)
Additional comments
Other Comments
	Pvf1 has a role in controlling the embryonic migration of blood cells. (Cho et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078683 NM_001169321 RefSeq (Proteins) • NP_523407 NP_001162792 DDBJ / EMBL / GenBank • AA950267 AA950511 AAF48892 AAK93175 AAL91091 AAL91093 ACZ95326 AJ401391 AJ426989 AQ254783 AW942906 AY051751 AY079186 AY079188 BG638593 CAC24699 CZ482352 CZ482353 CZ484832 Entrez Gene - A searchable database of RefSeq genes. • 32876 UniProtKB/TrEMBL • Q9BLX1 Q9VWP6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Platelet-derived growth factor (PDGF) (IPR000072)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59185 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030964 DroID - A comprehensive database of gene and protein interactions. • FBgn0030964 DRSC - Results from RNAi screens. • FBgn0030964 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030964 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7103-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030964 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32876 InParanoid A subset of ortholog calls from InParanoid. • AAEL013840-PA Aedes aegypti (mosquito) AGAP000574-PA Anopheles gambiae (mosquito) XP_392204.1 Apis mellifera (honey bee) XP_001950669.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000007026 Bos taurus (bovine) CE21657 Caenorhabditis elegans (worm) CPIJ012748 Culex pipens (mosquito) ENSECAP00000010054 Equus caballus (horse) ENSGACP00000021634 Gymnopilus aculeatus (mushroom) ISCW021859-PA Ixodes scapularis (deer tick) ENSMODP00000027011 Monodelphis domestica (gray opossum) ENSORLP00000002709 Oryzias latipes (japanese killifish) PHUM007028-PA Pediculus humanus (human body louse) XP_001184357.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001186746.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000006486 Tetraodon nigroviridis (green spotted pufferfish) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/pvf1_ligand.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32876 modMine - Data generated by the modENCODE project. • FBgn0030964 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV23126 LH23674 ISCW021859 FBgn0235198 FBgn0218526 FBgn0206039 FBgn0188967 FBgn0177791 FBgn0177790 FBgn0173627 JGI_V11_98897 JGI_V11_308843 FBgn0080100 FBgn0137836 FBgn0131976 FBgn0111396 FBgn0096065 CPIJ012748 BGIBMGA001092 ACYPI53639 ACYPI32275 ACYPI24120 ACYPI008173 ACYPI007115 ACYPI006308 GB12643 AGAP000574 AAEL013840 PB20428 PHUM138740 GLEAN_07448
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	CG7103 (Peter et al., 2002, Cho et al., 2002, Keleman et al., 2009.8.5, Munier et al., 2002) DmVEGF-1 (Heino et al., 2001, ) EP1624   l(1)G0146 (Schaefer et al., 1999.12.14, ) PVF (Reif and Cyster, 2002, Starz-Gaiano and Montell, 2004, Friedman and Perrimon, 2006, Meller et al., 2005) Pvf (Sims et al., 2009) PVF1 (Rorth, 2002, Starz-Gaiano and Montell, 2004, McDonald et al., 2004, Rosin et al., 2002, Duchek and Rorth, 2002, McDonald et al., 2006, Bunt et al., 2007, Montell, 2006) pvf1 (McDonald et al., 2003, Bunt et al., 2010) Pvf1 (Macias et al., 2004, Legube et al., 2006, Jekely et al., 2005, Harris et al., 2007, Wood et al., 2006, Bianco et al., 2007, Munier et al., 2002, Mathieu et al., 2007, Brandt and Corces, 2008, Franciscovich et al., 2008, Zeitlinger et al., 2007, Witsell et al., 2009, Hill-Burns and Clark, 2009, Wu et al., 2009, Sims et al., 2009, Janssens et al., 2010, Popodi, 2010.10.8, Wasbrough et al., 2010) PVFs (Ribeiro et al., 2003) unnamed (Kraut et al., 2001) VEGF (Traver and Zon, 2002, Zeitouni et al., 2007) vegf1 (Li and White, 2003) VEGF2-B (Cho, 2002.2.19) Vegf17E (Cho et al., 2002, Cho et al., 2002) Vegf17e-a (Carroll, 2002.2.19) Vegf17e-b (Cho, 2002.2.19)
Name Synonym	PDGF (platelet-derived growth factor)- and VEGF (vascular endothelial growth factor)-related factor 1 (Montell, 2006) PDGF- and VEGF-related factor 1
Secondary FlyBase IDs
	FBgn0029073 FBgn0044470
References ( 67 )
Generate a list of	All references relating to this gene ( 67 )
List References by type	Research paper  ( 25 ) Supplementary material  ( 7 ) Review  ( 10 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 8 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Computer file  ( 3 )
Recent research papers ( 2 )
	Bunt et al., 2010, Dev. Cell 19(2): 296--306 Hemocyte-Secreted Type IV Collagen Enhances BMP Signaling to Guide Renal Tubule Morphogenesis in Drosophila. [FBrf0211514] Janssens et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(16): 7323--7328 Direct detection of guidance receptor activity during border cell migration. [FBrf0210632] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...