FlyBase Gene Report: Dmel\kek5

General Information

Symbol

Dmel\kek5

Species

D. melanogaster

Name

kekkon 5

Annotation Symbol

CG12199

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031016

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

kekkon 5 (kek5) encodes a transmembrane protein involved in BMP signaling regulation. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

CT10486, kekkon-like

Key Links

Genomic Location

Cytogenetic map

18C3-18C7

Sequence location

X:19,353,181..19,471,914 [+]

Recombination map

1-62

RefSeq locus

NC_004354 REGION:19353181..19471914

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (2 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in negative regulation of BMP signaling pathway

inferred from mutant phenotype

(Evans et al., 2009)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in integral component of plasma membrane

inferred from direct assay

(Evans et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in integral component of plasma membrane

inferred from sequence model

(Derheimer et al., 2004)

Gene Group (FlyBase)

KEKKONS

Pathway (FlyBase)

Negative Regulators of BMP Signaling Pathway

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

kekkon 5 (kek5) encodes a transmembrane protein involved in BMP signaling regulation. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

KEKKONS -: Kekkons are transmembrane leucine-rich repeat (LRR) and immunoglobulin-like (Ig) domain-containing (LIG) proteins. Kekkons may function in cell adhesion and the modulation of receptor tyrosine kinase signaling. (Adapted from FBrf0179316, FBrf0207272 and FBrf0107731).

Pathway (FlyBase)

Negative Regulators of BMP Signaling Pathway -: Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\kek5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VWI6)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.40

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

kek5-RA

FBtr0074708

NM_133154

4374

931

kek5-RB

FBtr0074707

NM_167647

4444

931

kek5-RC

FBtr0309223

NM_167648

4544

931

kek5-RD

FBtr0309224

NM_001258817

6284

931

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

kek5-PA

FBpp0074477

102.5

931

8.27

NP_573382

AAF48953

kek5-PB

FBpp0074476

102.5

931

8.27

NP_728242

AAN09488

kek5-PC

FBpp0301162

102.5

931

8.27

NP_728243

AAN09489

kek5-PD

FBpp0301163

102.5

931

8.27

NP_001245746

AFH07458

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

931 aa isoforms: kek5-PA, kek5-PB, kek5-PC, kek5-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kek5 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kek5_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

organism | gap expression pattern

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

dorsal epidermis primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic foregut

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic large intestine

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

presumptive embryonic/larval central nervous system

• plasma membrane

(Evans et al., 2009)

embryonic/larval central nervous system

• plasma membrane

(Evans et al., 2009)

larval stage

haltere disc

• plasma membrane

(Evans et al., 2009)

eye-antennal disc

• plasma membrane

(Evans et al., 2009)

ventral thoracic disc

• plasma membrane

(Evans et al., 2009)

third instar larval stage

wing disc

• plasma membrane

(Evans et al., 2009)

pupal stage

wing

• plasma membrane

(Evans et al., 2009)

adult stage | female

ovary

• plasma membrane

(Evans et al., 2009)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

kek5 expression appears to be ubiquitous in most tissues throughout embryonic and larval stages and staining is membrane-localized. It is expressed uniformly in wing, leg, haltere, and eye-antennal discs and is expressed in both somatic and germline cells of the adult ovary. kek5 protein is enriched in the developing embryonic CNS.

(Evans et al., 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in integral component of plasma membrane

inferred from direct assay

(Evans et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\kek5 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\kek5

View exonic expression by tissue for Dmel\kek5

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32930/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031016

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031016

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031016

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12199

Flygut - An atlas of the Drosophila adult midgut

FBgn0031016

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 26 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of kek5

Transgenic constructs containing regulatory region of kek5

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(1)Exel7468

(Ryder, 2004.4.26)

Df(1)fe148

(Evans et al., 2009)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

kek5^GD14493

viable, with Scer\GAL4^Mef2.PR

kek5^GD14493

viable, with Scer\GAL4^pnr-MD237

kek5^GD14493

viable, with Scer\GAL4^tin.CΔ4

kek5^GD14493

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal size, with Scer\GAL4^Bx-MS1096

kek5^UAS.GFP

abnormal size, with Scer\GAL4^en-e16E

kek5^UAS.GFP

abnormal size, with Scer\GAL4^ptc-559.1

kek5^UAS.GFP

short lived | recessive

visible, with Scer\GAL4^Bx-MS1096

kek5^UAS.GFP

visible, with Scer\GAL4^en-e16E

kek5^UAS.GFP

visible, with Scer\GAL4^pnr-MD237

kek5^GD14493

visible, with Scer\GAL4^ptc-559.1

kek5^UAS.GFP

visible (with Df(1)Exel7468)

visible (with Df(1)JA27)

visible (with kek5^fe148)

kek5^Δ1

visible (with kek5^Δ1)

kek5^fe148

visible | recessive

Phenotype manifest in

Allele

anterior crossvein, with Scer\GAL4^Bx-MS1096

kek5^UAS.GFP

anterior crossvein, with Scer\GAL4^en-e16E

kek5^UAS.GFP

anterior crossvein, with Scer\GAL4^ptc-559.1

kek5^UAS.GFP

crossvein

crossvein (with Df(1)Exel7468)

crossvein (with Df(1)JA27)

crossvein (with kek5^fe148)

kek5^Δ1

crossvein (with kek5^Δ1)

kek5^fe148

mesothoracic tergum, with Scer\GAL4^pnr-MD237

kek5^GD14493

posterior crossvein, with Scer\GAL4^en-e16E

kek5^UAS.GFP

scutellar bristle | increased number, with Scer\GAL4^ptc-559.1

kek5^UAS.GFP

wing, with Scer\GAL4^Bx-MS1096

kek5^UAS.GFP

wing, with Scer\GAL4^en-e16E

kek5^UAS.GFP

wing, with Scer\GAL4^ptc-559.1

kek5^UAS.GFP

wing blade

wing blade, with Scer\GAL4^Bx-MS1096

kek5^UAS.GFP

wing blade, with Scer\GAL4^en-e16E

kek5^UAS.GFP

wing blade, with Scer\GAL4^ptc-559.1

kek5^UAS.GFP

wing blade (with Df(1)Exel7468)

wing blade (with Df(1)JA27)

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (27)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\LRFN1

2 of 15

Yes

Hsap\LRIT2

2 of 15

Yes

Hsap\SLITRK3

2 of 15

Yes

Hsap\FLRT2

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\LRFN2

1 of 15

Yes

Hsap\LRFN3

1 of 15

Yes

Hsap\LRFN4

1 of 15

Yes

Hsap\LRFN5

1 of 15

Yes

Hsap\LRIT1

1 of 15

Yes

Hsap\LRIT3

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\LRRC24

1 of 15

Hsap\RTN4R

1 of 15

Hsap\RTN4RL1

1 of 15

Yes

Hsap\RTN4RL2

1 of 15

Hsap\SLITRK1

1 of 15

Yes

Hsap\SLITRK2

1 of 15

Yes

Hsap\SLITRK4

1 of 15

Yes

Hsap\SLITRK5

1 of 15

Hsap\SLITRK6

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (25)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Lrfn1

2 of 15

Yes

Mmus\Lrit2

2 of 15

Yes

Mmus\Lrrc24

2 of 15

Yes

Mmus\Amigo3

1 of 15

Yes

Mmus\Flrt1

1 of 15

Yes

Mmus\Flrt2

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Lrfn2

1 of 15

Yes

Mmus\Lrfn3

1 of 15

Yes

Mmus\Lrfn4

1 of 15

Mmus\Lrfn5

1 of 15

Yes

Mmus\Lrit1

1 of 15

Yes

Mmus\Lrit3

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (23)

Rnor\Lrit2

3 of 13

Yes

Rnor\Lrfn1

2 of 13

Yes

Rnor\Lrit1

2 of 13

Yes

Rnor\Lrrc24

2 of 13

Rnor\Amigo3

1 of 13

Yes

Rnor\Flrt2

1 of 13

Yes

Rnor\Lgr6

1 of 13

Rnor\Lingo1

1 of 13

Rnor\Lingo3

1 of 13

Yes

Rnor\Lingo4

1 of 13

Yes

Rnor\Lrfn2

1 of 13

Yes

Rnor\Lrfn3

1 of 13

Yes

Rnor\Lrfn4

1 of 13

Rnor\Lrfn5

1 of 13

Yes

Rnor\Lrit3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Rtn4rl2

1 of 13

Yes

Rnor\Rtn4r

1 of 13

Yes

Rnor\Slitrk1

1 of 13

Rnor\Slitrk3

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (12)

Xtro\lrit2

3 of 12

Yes

Xtro\lrfn2

2 of 12

Yes

Xtro\LOC100486910

1 of 12

Yes

Xtro\LOC100488097

1 of 12

Yes

Xtro\lrfn1

1 of 12

Yes

Xtro\lrfn3

1 of 12

Yes

Xtro\lrfn4

1 of 12

Yes

Xtro\lrfn5

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (16)

Drer\lrfn2b

2 of 15

Yes

Drer\lrfn5a

2 of 15

Yes

Drer\lrit2

2 of 15

Yes

Drer\lrit3b

2 of 15

Yes

Drer\si:cabz01090165.1

2 of 15

Yes

Drer\LOC110437730

1 of 15

Yes

Drer\lrfn1

1 of 15

Yes

Drer\lrfn2

1 of 15

Yes

Drer\lrfn4a

1 of 15

Yes

Drer\lrfn5b

1 of 15

Yes

Drer\lrit1a

1 of 15

Yes

Drer\lrit1b

1 of 15

Yes

Drer\lrit3a

1 of 15

Yes

Drer\lrrc24

1 of 15

Drer\slitrk6

1 of 15

Yes

Drer\zgc:172282

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\iglr-3

4 of 15

Yes

Cele\pxn-1

1 of 15

Arabidopsis thaliana (thale-cress) (1)

Atha\AT1G33590

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (28)

Gene Symbol

Score

Source

Alignment

2 of 10

1 of 10

18w

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

chp

1 of 10

kek6

1 of 10

ltl

1 of 10

rdo

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

trn

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

kek5

anti tag coimmunoprecipitation, anti tag western blot

(MacLaren et al., 2004)

kek5 - kek1

anti tag coimmunoprecipitation, anti tag western blot

(MacLaren et al., 2004)

kek5 - kek2

anti tag coimmunoprecipitation, anti tag western blot

(MacLaren et al., 2004)

kek5 - kek6

anti tag coimmunoprecipitation, anti tag western blot

(MacLaren et al., 2004)

kek5 - spz5

anti tag coimmunoprecipitation, anti tag western blot

(Ulian-Benitez et al., 2017)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

gbb

suppressible

kek5

(Evans et al., 2009)

NT1|spz5

suppressible

kek5

(Ulian-Benitez et al., 2017)

sax

enhanceable

kek5

(Evans et al., 2009)

sog

suppressible

kek5

(Evans et al., 2009)

sog

enhanceable

kek5

(Evans et al., 2009)

tkv

suppressible

kek5

(Evans et al., 2009)

tkv

enhanceable

kek5

(Evans et al., 2009)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59233

DroID - A comprehensive database of gene and protein interactions.

FBgn0031016

MIST (genetic) - An integrated Molecular Interaction Database

kek5

MIST (protein-protein) - An integrated Molecular Interaction Database

kek5

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of BMP Signaling Pathway -: Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Axonal growth inhibition (RHOA activation)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-62

Cytogenetic map

18C3-18C7

Sequence location

X:19,353,181..19,471,914 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

18C3-18C7

Limits computationally determined from genome sequence between P{EP}CG8051^EP1550&P{EP}EP1300 and P{EP}EP1526&P{EP}Pfrx^EP1150

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-62

(FlyBase, 2016)

1-61.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

40830

y¹ v¹; P{TRiP.HMS01996}attP40

64048

w¹¹¹⁸ PBac{IT.GAL4}kek5^0816-G4

34433

y¹ w^* Mi{MIC}kek5^MI01444

51204

y¹ w^* Mi{MIC}kek5^MI05980

56624

y¹ w^* Mi{MIC}kek5^MI11781

57896

y¹ w^* Mi{MIC}kek5^MI12217

Kyoto

103644

y^* w^* P{GawB}kek5^NP0541 / FM7c

103855

y^* w^* P{GawB}kek5^NP1008 / FM7c

VDRC

v1401

w¹¹¹⁸ P{GD36}v1401

v47771

w¹¹¹⁸; P{GD14493}v47771

v342235

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01857}attP40/CyO-GFP

Genomic Clones (50)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (70)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LP23752

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031016

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031016

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32930

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Evans et al., 2009)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: kek5 CG12199

(FlyBase, 1996-)

Source for database merge of

Additional comments

Source for identity of kek5 CG12199 was sequence comparison ( date:030311 ).

(FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 80 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32930

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VWI6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VWI6

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031016

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32930/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031016

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kek5_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031016

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031016

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12199

Flygut - An atlas of the Drosophila adult midgut

FBgn0031016

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32930

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007110

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG12199

MARRVEL_MODEL - MARRVEL (model organism gene)

32930

modMine - A data warehouse for the modENCODE project

FBgn0031016

Linkouts

BioGRID - A database of protein and genetic interactions.

59233

DroID - A comprehensive database of gene and protein interactions.

FBgn0031016

DRSC - Results frm RNAi screens

FBgn0031016

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031016

FlyMine - An integrated database for Drosophila genomics

FBgn0031016

MIST (genetic) - An integrated Molecular Interaction Database

kek5

MIST (protein-protein) - An integrated Molecular Interaction Database

kek5

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Axonal growth inhibition (RHOA activation)

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG12199

(Kim et al., 2021, Meadows, 2014.12.12, Ni et al., 2010.12.1, Zhang et al., 2010, Duffy, 2003.3.6, Giot et al., 2003)

CT10486

(Vogel et al., 2003, Hynes and Zhao, 2000, Hynes and Zhao, 2000)

Kek5

(Evans, 2002.12.11)

kek-5

(Ulian-Benitez et al., 2017)

kek5

(Michki et al., 2021, Shih et al., 2019, Grobler et al., 2018, Ulian-Benitez et al., 2017, Clandinin and Owens, 2016-, Duff et al., 2015, Ashwal-Fluss et al., 2014, Vernes, 2014, Ozkan et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Leatherman and Dinardo, 2010, Evans et al., 2009, Hueber et al., 2007, Badal et al., 2006)

Name Synonyms

Kekkon5

(Evans et al., 2009)

kekkon 5

kekkon-like

(Hynes and Zhao, 2000, Hynes and Zhao, 2000)

kekkon5

(Leatherman and Dinardo, 2010)

Secondary FlyBase IDs

Datasets (8)

Study focus (0)

Experimental Role