FB2020_05, released Oct 14, 2020

Gene: Dmel\kek5

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General Information
Symbol
Dmel\kek5
Species
D. melanogaster
Name
kekkon 5
Annotation Symbol
CG12199
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031016
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
kekkon 5 (kek5) encodes a transmembrane protein involved in BMP signaling regulation. [Date last reviewed: 2019-09-12]
Other Summaries
Also Known As

CT10486, kekkon-like

Key Links
Genomic Location
Cytogenetic map
18C3-18C7
Sequence location
X:19,353,181..19,471,914 [+]
Recombination map

1-62

RefSeq locus
NC_004354 REGION:19353181..19471914
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
negative regulation of BMP signaling pathway
inferred from mutant phenotype
(Evans et al., 2009)
NOT negative regulation of epidermal growth factor receptor signaling pathway
inferred from mutant phenotype
(Alvarado et al., 2004)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
integral component of plasma membrane
inferred from direct assay
(Evans et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
integral component of plasma membrane
inferred from sequence model
(Derheimer et al., 2004)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
KEKKONS -
Kekkons are transmembrane leucine-rich repeat (LRR) and immunoglobulin-like (Ig) domain-containing (LIG) proteins. Kekkons may function in cell adhesion and the modulation of receptor tyrosine kinase signaling. (Adapted from FBrf0179316, FBrf0207272 and FBrf0107731).
Pathway (FlyBase)
Negative Regulators of BMP Signaling Pathway -
Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\kek5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.40

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
kek5-RA
FBtr0074708
NM_133154
4374
931
kek5-RB
FBtr0074707
NM_167647
4444
931
kek5-RC
FBtr0309223
NM_167648
4544
931
kek5-RD
FBtr0309224
NM_001258817
6284
931
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
kek5-PA
FBpp0074477
102.5
931
8.27
NP_573382
AAF48953
kek5-PB
FBpp0074476
102.5
931
8.27
NP_728242
AAN09488
kek5-PC
FBpp0301162
102.5
931
8.27
NP_728243
AAN09489
kek5-PD
FBpp0301163
102.5
931
8.27
NP_001245746
AFH07458
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

931 aa isoforms: kek5-PA, kek5-PB, kek5-PC, kek5-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kek5 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
organism | gap expression pattern
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
dorsal epidermis primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic foregut
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic large intestine
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
ovary
(Evans et al., 2009)
third instar larval stage
wing disc
(Evans et al., 2009)
pupal stage
wing
(Evans et al., 2009)
embryonic stage
presumptive embryonic/larval central nervous system
(Evans et al., 2009)
embryonic/larval central nervous system
(Evans et al., 2009)
larval stage
haltere disc
(Evans et al., 2009)
eye-antennal disc
(Evans et al., 2009)
ventral thoracic disc
(Evans et al., 2009)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

kek5 expression appears to be ubiquitous in most tissues throughout embryonic and larval stages and staining is membrane-localized. It is expressed uniformly in wing, leg, haltere, and eye-antennal discs and is expressed in both somatic and germline cells of the adult ovary. kek5 protein is enriched in the developing embryonic CNS.

(Evans et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
integral component of plasma membrane
inferred from direct assay
(Evans et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\kek5 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 25 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of kek5
Transgenic constructs containing regulatory region of kek5
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
short lived | recessive
size defective, with Scer\GAL4Bx-MS1096
size defective, with Scer\GAL4en-e16E
size defective, with Scer\GAL4ptc-559.1
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4ptc-559.1
visible (with Df(1)Exel7468)
visible (with Df(1)JA27)
visible (with kek5fe148)
visible (with kek5Δ1)
visible | recessive
Phenotype manifest in
Allele
anterior crossvein, with Scer\GAL4Bx-MS1096
anterior crossvein, with Scer\GAL4en-e16E
anterior crossvein, with Scer\GAL4ptc-559.1
crossvein
crossvein (with Df(1)Exel7468)
crossvein (with Df(1)JA27)
crossvein (with kek5fe148)
crossvein (with kek5Δ1)
mesothoracic tergum, with Scer\GAL4pnr-MD237
posterior crossvein, with Scer\GAL4en-e16E
scutellar bristle | supernumerary, with Scer\GAL4ptc-559.1
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4en-e16E
wing, with Scer\GAL4ptc-559.1
wing blade
wing blade, with Scer\GAL4Bx-MS1096
wing blade, with Scer\GAL4en-e16E
wing blade, with Scer\GAL4ptc-559.1
wing blade (with Df(1)Exel7468)
wing blade (with Df(1)JA27)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (27)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\LRFN1
2 of 15
Yes
Yes
Hsap\LRIT2
2 of 15
Yes
Yes
Hsap\SLITRK3
2 of 15
Yes
Yes
Hsap\FLRT2
1 of 15
No
Yes
Hsap\LINGO1
1 of 15
No
No
Hsap\LINGO2
1 of 15
No
No
Hsap\LINGO3
1 of 15
No
No
Hsap\LINGO4
1 of 15
No
Yes
Hsap\LRFN2
1 of 15
No
Yes
Hsap\LRFN3
1 of 15
No
Yes
Hsap\LRFN4
1 of 15
No
Yes
Hsap\LRFN5
1 of 15
No
Yes
Hsap\LRIT1
1 of 15
No
Yes
Hsap\LRIT3
1 of 15
No
Yes
Hsap\LRRC4B
1 of 15
No
No
Hsap\LRRC4C
1 of 15
No
No
Hsap\LRRC4
1 of 15
No
No
1  
Hsap\LRRC19
1 of 15
No
Yes
Hsap\LRRC24
1 of 15
No
No
Hsap\RTN4R
1 of 15
No
No
Hsap\RTN4RL1
1 of 15
No
Yes
Hsap\RTN4RL2
1 of 15
No
No
Hsap\SLITRK1
1 of 15
No
Yes
Hsap\SLITRK2
1 of 15
No
Yes
Hsap\SLITRK4
1 of 15
No
Yes
Hsap\SLITRK5
1 of 15
No
No
Hsap\SLITRK6
1 of 15
No
Yes
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (25)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Lrfn1
2 of 15
Yes
Yes
Mmus\Lrit2
2 of 15
Yes
Yes
Mmus\Lrrc24
2 of 15
Yes
No
Mmus\Amigo3
1 of 15
No
Yes
Mmus\Flrt1
1 of 15
No
Yes
Mmus\Flrt2
1 of 15
No
Yes
Mmus\Lgr6
1 of 15
No
No
Mmus\Lingo1
1 of 15
No
No
Mmus\Lingo2
1 of 15
No
No
Mmus\Lingo3
1 of 15
No
No
Mmus\Lingo4
1 of 15
No
Yes
Mmus\Lrfn2
1 of 15
No
Yes
Mmus\Lrfn3
1 of 15
No
Yes
Mmus\Lrfn4
1 of 15
No
No
Mmus\Lrfn5
1 of 15
No
Yes
Mmus\Lrit1
1 of 15
No
Yes
Mmus\Lrit3
1 of 15
No
Yes
Mmus\Lrrc4b
1 of 15
No
No
Mmus\Lrrc4c
1 of 15
No
No
Mmus\Lrrc4
1 of 15
No
No
Mmus\Rtn4rl1
1 of 15
No
Yes
Mmus\Rtn4rl2
1 of 15
No
No
Mmus\Rtn4r
1 of 15
No
No
Mmus\Slitrk1
1 of 15
No
No
Mmus\Slitrk3
1 of 15
No
No
Rattus norvegicus (Norway rat) (23)
Rnor\Lrit2
3 of 13
Yes
Yes
Rnor\Lrfn1
2 of 13
No
Yes
Rnor\Lrit1
2 of 13
No
Yes
Rnor\Lrrc24
2 of 13
No
No
Rnor\Amigo3
1 of 13
No
Yes
Rnor\Flrt2
1 of 13
No
Yes
Rnor\Lgr6
1 of 13
No
No
Rnor\Lingo1
1 of 13
No
No
Rnor\Lingo3
1 of 13
No
Yes
Rnor\Lingo4
1 of 13
No
Yes
Rnor\Lrfn2
1 of 13
No
Yes
Rnor\Lrfn3
1 of 13
No
Yes
Rnor\Lrfn4
1 of 13
No
No
Rnor\Lrfn5
1 of 13
No
Yes
Rnor\Lrit3
1 of 13
No
Yes
Rnor\Lrrc4b
1 of 13
No
No
Rnor\Lrrc4c
1 of 13
No
No
Rnor\Lrrc4
1 of 13
No
No
Rnor\Rtn4rl1
1 of 13
No
Yes
Rnor\Rtn4rl2
1 of 13
No
Yes
Rnor\Rtn4r
1 of 13
No
Yes
Rnor\Slitrk1
1 of 13
No
No
Rnor\Slitrk3
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (12)
Xtro\lrit2
3 of 12
Yes
Yes
Xtro\lrfn2
2 of 12
No
Yes
Xtro\LOC100486910
1 of 12
No
Yes
Xtro\LOC100488097
1 of 12
No
Yes
Xtro\lrfn1
1 of 12
No
Yes
Xtro\lrfn3
1 of 12
No
Yes
Xtro\lrfn4
1 of 12
No
Yes
Xtro\lrfn5
1 of 12
No
Yes
Xtro\lrrc15
1 of 12
No
No
Xtro\lrrc24
1 of 12
No
No
Xtro\slitrk1
1 of 12
No
No
Xtro\slitrk6
1 of 12
No
No
Danio rerio (Zebrafish) (16)
Drer\lrfn2b
2 of 15
Yes
Yes
Drer\lrfn5a
2 of 15
Yes
Yes
Drer\lrit2
2 of 15
Yes
Yes
Drer\lrit3b
2 of 15
Yes
Yes
Drer\si:cabz01090165.1
2 of 15
Yes
Yes
Drer\LOC110437730
1 of 15
No
Yes
Drer\lrfn1
1 of 15
No
Yes
Drer\lrfn2
1 of 15
No
Yes
Drer\lrfn4a
1 of 15
No
Yes
Drer\lrfn5b
1 of 15
No
Yes
Drer\lrit1a
1 of 15
No
Yes
Drer\lrit1b
1 of 15
No
Yes
Drer\lrit3a
1 of 15
No
Yes
Drer\lrrc24
1 of 15
No
No
Drer\slitrk6
1 of 15
No
Yes
Drer\zgc:172282
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\iglr-3
4 of 15
Yes
Yes
Cele\pxn-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\AT1G33590
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904C6 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004779
Drosophila simulans
Dsim\GD28076
Drosophila sechellia
Dsec\GM22957
Drosophila erecta
Dere\GG19223
Drosophila yakuba
Dyak\GE15841
Drosophila ananassae
Dana\GF20190
Drosophila pseudoobscura pseudoobscura
Dpse\GA11471
Drosophila persimilis
Dper\GL14526
Drosophila willistoni
Dwil\GK15070
Drosophila virilis
Dvir\GJ15735
Drosophila mojavensis
Dmoj\GI16086
Drosophila grimshawi
Dgri\GH17649
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502JG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011847
Glossina morsitans
Tsetse fly
Gmor\GMOY008141
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02334
Mayetiola destructor
Hessian fly
Mdes\Mdes006833
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012727
Anopheles darlingi
American malaria mosquito
Adar\ADAC006455
Anopheles gambiae
Malaria mosquito
Agam\AGAP002336
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001169
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03WI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009489
Bombyx mori
Silkmoth
Bmor\BGIBMGA009485
Danaus plexippus
Monarch butterfly
Dple\DPOGS200394-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS204793-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017672
Heliconius melpomene
Postman butterfly
Hmel\HMEL014620
Apis florea
Little honeybee
Aflo\3554757236
Apis mellifera
Western honey bee
Amel\GB52933
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14756
Bombus terrestris
Buff-tailed bumblebee
Bter\15214521
Linepithema humile
Argentine ant
Lhum\LH13800
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0013b5
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012530
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09632
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07110
Pediculus humanus
Human body louse
Phum\PHUM275740
Rhodnius prolixus
Kissing bug
Rpro\RPRC013207
Cimex lectularius
Bed bug
Clec\CLEC013172
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008566
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10894
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09M0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tlr225
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lrr/Igr_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lrrc4cL
Ciona intestinalis
Vase tunicate
Cint\LOC100179272
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023315
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005001
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (28)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
kek4
2 of 10
2mit
1 of 10
18w
1 of 10
caps
1 of 10
cDIP
1 of 10
CG4168
1 of 10
CG4950
1 of 10
CG5810
1 of 10
CG6749
1 of 10
CG7800
1 of 10
CG7896
1 of 10
CG16974
1 of 10
CG18249
1 of 10
CG18480
1 of 10
CG32055
1 of 10
CG42346
1 of 10
CG42709
1 of 10
chp
1 of 10
kek6
1 of 10
ltl
1 of 10
rdo
1 of 10
Tl
1 of 10
Toll-4
1 of 10
Toll-6
1 of 10
Toll-7
1 of 10
Toll-9
1 of 10
Tollo
1 of 10
trn
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    kek5
    anti tag coimmunoprecipitation, anti tag western blot
    (MacLaren et al., 2004)
    kek5 - kek1
    anti tag coimmunoprecipitation, anti tag western blot
    (MacLaren et al., 2004)
    kek5 - kek2
    anti tag coimmunoprecipitation, anti tag western blot
    (MacLaren et al., 2004)
    kek5 - kek6
    anti tag coimmunoprecipitation, anti tag western blot
    (MacLaren et al., 2004)
    kek5 - spz5
    anti tag coimmunoprecipitation, anti tag western blot
    (Ulian-Benitez et al., 2017)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    gbb
    suppressible
    kek5
    (Evans et al., 2009)
    NT1|spz5
    suppressible
    kek5
    (Ulian-Benitez et al., 2017)
    sax
    enhanceable
    kek5
    (Evans et al., 2009)
    sog
    suppressible
    kek5
    (Evans et al., 2009)
    sog
    enhanceable
    kek5
    (Evans et al., 2009)
    tkv
    enhanceable
    kek5
    (Evans et al., 2009)
    tkv
    suppressible
    kek5
    (Evans et al., 2009)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Negative Regulators of BMP Signaling Pathway -
    Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
    Metabolic Pathways
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map

    1-62

    Cytogenetic map
    18C3-18C7
    Sequence location
    X:19,353,181..19,471,914 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    18C3-18C7
    Limits computationally determined from genome sequence between P{EP}CG8051EP1550&P{EP}EP1300 and P{EP}EP1526&P{EP}PfrxEP1150
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    1-62

    (FlyBase, 2016)

    1-61.5

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (14)
    Genomic Clones (50)
    cDNA Clones (70)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Evans et al., 2009)
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: kek5 CG12199

    (FlyBase, 1996-)
    Source for database merge of
    Additional comments

    Source for identity of kek5 CG12199 was sequence comparison ( date:030311 ).

    (FlyBase, 1996-)
    Other Comments
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 77 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (9)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (58)