FlyBase Gene Report: Dmel\CG14207

SMALL HEAT SHOCK PROTEINS -: The small Heat Shock Protein (sHSP) family is characterized by the presence of an α-crystallin domain. sHSPs play a crucial role in protein folding. Most sHSPs have the ability to prevent protein aggregation and to maintain substrate proteins in a refoldable state. (Adapted from FBrf0228040 and FBrf0231212).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\CG14207 or the JBrowse view of Dmel\CG14207 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG14207-RA

FBtr0074733

NM_134482

1240

183

CG14207-RB

FBtr0074734

NM_167669

1267

192

CG14207-RC

FBtr0307161

NM_001258831

753

154

CG14207-RD

FBtr0345918

NM_001298517

1380

183

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CG14207-PA

FBpp0074502

20.8

183

5.74

NP_608326

AAF48980

CG14207-PB

FBpp0074503

21.8

192

6.54

NP_728275

AAN09508

CG14207-PC

FBpp0297990

17.1

154

9.42

NP_001245760

AFH07472

CG14207-PD

FBpp0311833

20.8

183

5.74

NP_001285446

AHN59916

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

183 aa isoforms: CG14207-PA, CG14207-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG14207 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (6 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

unfolded protein binding

inferred from sequence model

(Li et al., 2009)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

protein refolding

inferred from direct assay

(Vos et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

chaperone-mediated protein folding

inferred from sequence model

(Li et al., 2009)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

Z disc

inferred from direct assay

(Lowe et al., 2014, Arndt et al., 2010)

colocalizes_with Z disc

inferred from direct assay

(Carra et al., 2010)

Terms Based on Predictions or Assertions (0 terms)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 9 -- 10

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

dorsal pharyngeal muscle primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal pharyngeal muscle

(Fisher et al., 2012)

embryonic/larval dorsal vessel

(Fisher et al., 2012)

embryonic/larval muscle system

(Fisher et al., 2012)

embryonic/larval somatic muscle

(Fisher et al., 2012)

embryonic/larval visceral muscle

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

Z disc

inferred from direct assay

(Lowe et al., 2014, Arndt et al., 2010)

colocalizes_with Z disc

inferred from direct assay

(Carra et al., 2010)

Expression Deduced from Reporters

Reporter: PBac{810.P.FSVS-2}CG14207^CPTI004445

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

pedunculus of adult mushroom body

(Knowles-Barley, 2011.8.24)

calyx of adult mushroom body

(Knowles-Barley, 2011.8.24)

adult antennal lobe glomerulus | subset

Comment: patterned expression in adult antennal lobe, higher in some adult antennal lobe glomeruli

(Knowles-Barley, 2011.8.24)

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG14207 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG14207

View exonic expression by tissue for Dmel\CG14207

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031037

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0031037

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG14207-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14207

Flygut - An atlas of the Drosophila adult midgut

FBgn0031037

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CG14207

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 16 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG14207

Transgenic constructs containing regulatory region of CG14207

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

CG14207^CB02069

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG14207^GD7609

viable, with Scer\GAL4^Mef2.PR

CG14207^GD7609

viable, with Scer\GAL4^pnr-MD237

CG14207^GD7609

viable, with Scer\GAL4^tin.CΔ4

CG14207^GD7609

Other Phenotypes

Allele

long lived, with Scer\GAL4^elav.PLu

CG14207^UAS.Tag:V5

long lived, with Scer\GAL4^ey.200.Exel

CG14207^UAS.Tag:V5

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (10)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CRYAB

5 of 15

Yes

Hsap\HSPB1

5 of 15

Yes

4 of 15

4 of 15

4 of 15

3 of 15

2 of 15

2 of 15

Yes

Hsap\HSPB8

2 of 15

Hsap\HSPB9

2 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (9)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Cryaa

5 of 15

Yes

Mmus\Cryab

5 of 15

Yes

4 of 15

4 of 15

3 of 15

2 of 15

2 of 15

Yes

Mmus\Hspb8

2 of 15

Mmus\Hspb9

2 of 15

Rattus norvegicus (Norway rat) (9)

Rnor\Cryaa

4 of 13

Yes

Rnor\Cryab

4 of 13

Yes

Rnor\Hspb1

4 of 13

Yes

Rnor\Hspb2

4 of 13

Yes

Rnor\Hspb6

4 of 13

Yes

Rnor\Hspb7

2 of 13

Yes

Rnor\Hspb8

2 of 13

Rnor\Hspb9

2 of 13

Yes

Rnor\Hspb3

1 of 13

Xenopus tropicalis (Western clawed frog) (10)

Xtro\cryaa

2 of 12

Yes

Xtro\cryab

2 of 12

Yes

Xtro\hspb1

2 of 12

Yes

Xtro\hspb2

2 of 12

Yes

Xtro\hspb6

2 of 12

Yes

Xtro\hspb8

2 of 12

Yes

Xtro\hsp30d

1 of 12

Xtro\hspb3

1 of 12

Xtro\LOC100489207

1 of 12

Yes

Xtro\uqcrh

1 of 12

Danio rerio (Zebrafish) (12)

Drer\cryaa

5 of 15

Yes

Drer\hspb1

5 of 15

Yes

4 of 15

4 of 15

4 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (19)

Cele\hsp-25

14 of 15

Yes

4 of 15

4 of 15

4 of 15

4 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (6)

Atha\AT1G04380

1 of 9

Yes

Atha\AT1G06645

1 of 9

Yes

Atha\AT1G07400

1 of 9

Yes

Atha\AT1G52560

1 of 9

Yes

Atha\AT2G06960

1 of 9

Yes

Atha\HSP21

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\hsp16

1 of 12

Yes

Spom\SPCC338.06c

1 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190GTG )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA12823

Drosophila persimilis

Dper\GL27055

Drosophila willistoni

Dwil\GK25198

Drosophila virilis

Dvir\GJ15970

Drosophila mojavensis

Dmoj\GI11114

Drosophila grimshawi

Dgri\GH24938

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150D6H )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17023722

Glossina morsitans

Tsetse fly

Gmor\GMOY000497

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_05314

Mayetiola destructor

Hessian fly

Mdes\Mdes016654

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001094

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL015090

Anopheles darlingi

American malaria mosquito

Adar\ADAC003522

Anopheles gambiae

Malaria mosquito

Agam\AGAP000941

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009818

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0PT6 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\Hsp21.4

Danaus plexippus

Monarch butterfly

Dple\DPOGS207471-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL004675

Apis florea

Little honeybee

Aflo\2189778276

Apis florea

Little honeybee

Aflo\2189778340

Apis florea

Little honeybee

Aflo\2163524994

Apis mellifera

Western honey bee

Amel\GB53550

Apis mellifera

Western honey bee

Amel\GB53549

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP19987

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP19986

Bombus terrestris

Buff-tailed bumblebee

Bter\15211846

Linepithema humile

Argentine ant

Lhum\LH19962

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00132f

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG005422

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11016

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11015

Tribolium castaneum

Red flour beetle

Tcas\TC001152

Pediculus humanus

Human body louse

Phum\PHUM217050

Pediculus humanus

Human body louse

Phum\PHUM217060

Pediculus humanus

Human body louse

Phum\PHUM217070

Pediculus humanus

Human body louse

Phum\PHUM621170

Rhodnius prolixus

Kissing bug

Rpro\RPRC008537

Cimex lectularius

Bed bug

Clec\CLEC025338

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003907

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09290

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0Q4E )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR004724

Ixodes scapularis

Black-legged tick

Isca\ISCW017709

Stegodyphus mimosarum

African social velvet spider

Smim\KFM69864.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65662.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur11g02770

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_208978

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (10)

Gene Symbol

Score

Source

Alignment

5 of 10

5 of 10

5 of 10

4 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 6 )

Human Ortholog

Disease

Evidence

References

CRYAB; crystallin alpha B

model of fatal infantile hypertonic myofibrillar myopathy

IEA

(FlyBase, 2019-)

model of cataract 16 multiple types

IEA

(FlyBase, 2019-)

model of dilated cardiomyopathy 1II

IEA

(FlyBase, 2019-)

model of myofibrillar myopathy 2

IEA

(FlyBase, 2019-)

HSPB1; heat shock protein family B (small) member 1

model of Charcot-Marie-Tooth disease axonal type 2F

IEA

(FlyBase, 2019-)

model of distal hereditary motor neuropathy type 2B

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

CG14207^EP1348

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Bilen and Bonini, 2007)

ameliorates neurodegenerative disease

modeled by Hsap\TARDBP^UAS.Tag:HA

(Gregory et al., 2012)

modeled by Hsap\TARDBP^{TDP-25.UAS.Tag:HA}

(Gregory et al., 2012)

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CRYAB; crystallin alpha B

5 of 15

123590

HSPB1; heat shock protein family B (small) member 1

5 of 15

602195

CRYAA; crystallin alpha A

4 of 15

123580

CATARACT 9, MULTIPLE TYPES; CTRCT9

cataract 9 multiple types

HSPB2; heat shock protein family B (small) member 2

4 of 15

602179

HSPB6; heat shock protein family B (small) member 6

4 of 15

610695

CRYAA2; crystallin alpha A2

3 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CG14207 - Act79B

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Actn

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Adh

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Ald1

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Argk

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - CG10581

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - CG5177

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - E(spl)m3-HLH

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Fer2LCH

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Gpdh1

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Mf

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Mhc

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Mlc1

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Mlc2

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Obp56d

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Prm

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Scp1

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Snr1

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Spc25

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - Tm2

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - TpnC41C

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - kdn

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - lolal

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - p38b

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - spag

anti tag coimmunoprecipitation, peptide massfingerprinting

(Benbahouche et al., 2014)

CG14207 - up

experimental knowledge based

(Guruharsha et al., 2011)

CG14207 - wupA

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59255

DroID - A comprehensive database of gene and protein interactions.

FBgn0031037

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32955

MIST (protein-protein) - An integrated Molecular Interaction Database

CG14207

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-63

Cytogenetic map

18D3-18D3

Sequence location

X:19,605,199..19,611,413 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

18D3-18D3

Limits computationally determined from genome sequence between P{EP}EP1348&P{EP}e(y)3^EP1036 and P{EP}Sec61γ^EP1511

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-63

(FlyBase, 2016)

1-62.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Bloomington

10147

w¹¹¹⁸ P{EP}CG14207^EP766

85499

w¹¹¹⁸ P{XP}CG14207^d08767

43564

y¹ w^* Mi{MIC}CG14207^MI05262

50833

y¹ w^* P{PTT-GB}CG14207^CB02069

15419

y¹ w^67c23 P{EPgy2}CG14207^EY02472

Kyoto

115451

w¹¹¹⁸ PBac{802.P.SVS-2}CG14207^CPTI003892

115622

w¹¹¹⁸ PBac{810.P.FSVS-2}CG14207^CPTI004445

104456

y^* w^* P{GawB}CG14207^NP3330 / FM7c

115597

w¹¹¹⁸ PBac{806.LOX-SVS-2}CG14207^CPTI003978

VDRC

v31800

w¹¹¹⁸; P{GD7609}v31800

v31802

w¹¹¹⁸; P{GD7609}v31802

v44831

w¹¹¹⁸; P{GD7609}v44831

More stocks available...

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (126)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031037

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031037

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32955

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

FlyBase Curator comment: Authors of FBrf0209888 say that 'CG14207' is "an uncharacterized fly homolog of [mammalian] HspB8", whereas FBrf0212431 shows there are several candidate genes for being this ortholog and actually conclude that 'Hsp67Bc' ('CG4190') is "the closest functional ortholog of human HSPB8". 'CG14207' has not been given the symbol 'HspB8' for this reason.

(Arndt et al., 2010)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 53 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32955

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.