FlyBase Gene Report: Dmel\Tyler

SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS -: The solute carrier family 25 (SLC25) or mitochondrial carrier family (MCF) members shuttle metabolites, nucleotides and cofactors across the inner mitochondrial membrane. (Adapted from FBrf0212481, FBrf0212949 and PMID:23266187).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Tyler or the JBrowse view of Dmel\Tyler for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.53

gene_with_dicistronic_mRNA ; SO:0000722

Gene model reviewed during 5.43

Gene model reviewed during 5.49

Gene model reviewed during 5.57

Sequence Ontology: Class of Gene

gene_with_dicistronic_mRNA

(FlyBase Genome Annotators, 2002-2003)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Tyler-RB

FBtr0074736

NM_134483

2964

441

Tyler-RF

FBtr0346616

NM_001298518

3255

333

Tyler-RG

FBtr0346617

NM_167671

3032

335

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Tyler-PB

FBpp0074505

48.8

441

9.21

NP_608327

AAN09509

Tyler-PF

FBpp0312196

36.8

333

8.37

NP_001285447

AHN59917

Tyler-PG

FBpp0312197

37.0

335

8.70

NP_728278

AAN09510

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tyler using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tyler_1

Linkouts

Gene Ontology (0 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tyler in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Tyler

View exonic expression by tissue for Dmel\Tyler

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031039

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0031038

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG33075-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0031038

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Tyler

Transgenic constructs containing regulatory region of Tyler

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SLC25A39

9 of 15

Yes

Hsap\SLC25A40

9 of 15

Yes

Hsap\SLC25A38

1 of 15

Yes

Hsap\ZNF37A

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Slc25a40

9 of 15

Yes

Mmus\Slc25a39

8 of 15

Mmus\Slc25a38

1 of 15

Yes

Rattus norvegicus (Norway rat) (3)

Rnor\Slc25a39

10 of 13

Yes

Rnor\Slc25a40

10 of 13

Yes

Rnor\Slc25a38

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\slc25a39

7 of 12

Yes

Xtro\slc25a40

6 of 12

Danio rerio (Zebrafish) (3)

Drer\slc25a40

9 of 15

Yes

Drer\slc25a39

8 of 15

Drer\slc25a38a

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\C16C10.1

8 of 15

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\MTM1

6 of 9

Yes

Atha\AT2G46320

4 of 9

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\MTM1

9 of 15

Yes

Scer\HEM25

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPBP23A10.06

9 of 12

Yes

Spom\SPAC823.10c

1 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091908ZG )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Tyler

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA23023

Drosophila persimilis

Dper\GL27056

Drosophila willistoni

Dwil\GK25199

Drosophila virilis

Dvir\GJ15971

Drosophila grimshawi

Dgri\GH24939

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0BF9 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006241

Danaus plexippus

Monarch butterfly

Dple\DPOGS211565-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008039

Apis florea

Little honeybee

Aflo\4402979076

Apis mellifera

Western honey bee

Amel\Ame.3200

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP14268

Bombus terrestris

Buff-tailed bumblebee

Bter\15204327

Linepithema humile

Argentine ant

Lhum\LH23157

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002e92

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG012242

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_01240

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03396

Tribolium castaneum

Red flour beetle

Tcas\TC000750

Pediculus humanus

Human body louse

Phum\PHUM103570

Rhodnius prolixus

Kissing bug

Rpro\RPRC011029

Cimex lectularius

Bed bug

Clec\CLEC004053

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003858

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007847

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13090

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BWR )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR008502

Ixodes scapularis

Black-legged tick

Isca\ISCW008286

Stegodyphus mimosarum

African social velvet spider

Smim\KFM73595.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM81683.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g13770

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_219561

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07QQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mcfp

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc25a40

Ciona intestinalis

Vase tunicate

Cint\LOC100179526

Gallus gallus

Domestic chicken

Ggal\SLC25A40

Gallus gallus

Domestic chicken

Ggal\SLC25A39

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

6 of 10

5 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC25A39; solute carrier family 25 member 39

9 of 15

610820

SLC25A40; solute carrier family 25 member 40

9 of 15

610821

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0031038

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

3772349

MIST (protein-protein) - An integrated Molecular Interaction Database

Tyler

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-63

Cytogenetic map

18D3-18D3

Sequence location

X:19,611,526..19,615,617 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

18D3-18D3

Limits computationally determined from genome sequence between P{EP}EP1348&P{EP}e(y)3^EP1036 and P{EP}Sec61γ^EP1511

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-63

(FlyBase, 2016)

1-62.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (2)

Bloomington

15190

y¹ P{SUPor-P}Tyler^KG09498

82728

y¹ v¹; P{TKO.GS05071}attP40

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (25)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031038

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031038

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

3772349

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Tyler CG14208

(Smith, 2002.10.14)

Source for database merge of

Additional comments

Dicistronic annotation CG33075 split out into separate annotations for each open reading frame, CG14208 and CG14209, in release 4.2 of the genome annotation. CG14208 corresponds to Tyler and CG14209 corresponds to Shawn.

(FlyBase Genome Annotators, 2005)

One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by Tyler and Shawn.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

Origin and Etymology

Discoverer

Etymology

The genes of this dicistronic locus seem to encode mitochondrial transporters, so are named "Tyler" and "Shawn" after two energetic, 9 and 11 year old boys adopted by Chris Smith's parents. Name "Tyler" chosen by Chris Smith to mark his contribution to the FlyBase Release 3 annotation project.

(Smith, 2002.10.14)

Identification

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3772349

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031039

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031038

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tyler_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0031038

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

3772349

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000750

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG14208

modMine - A data warehouse for the modENCODE project

FBgn0031038

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0031038

DRSC - Results frm RNAi screens

FBgn0031038

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0031038

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG33075-RA

FlyMine - An integrated database for Drosophila genomics

FBgn0031038

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

3772349

MIST (protein-protein) - An integrated Molecular Interaction Database

Tyler

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG14208

(Hosono et al., 2015, Smith, 2002.10.14, Nelson, 2000.4.10)

CG33075

(Gruenewald et al., 2009, Maines et al., 2007, Rehwinkel et al., 2006, Burgler and Macdonald, 2005)

Tyler

(Velentzas et al., 2018, Transgenic RNAi Project members, 2017-, Jungreis, 2011.11.18)

Name Synonyms

Tyler

Secondary FlyBase IDs

FBgn0053075

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (24)

Report Sections

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