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Gene Dmel\Tyler

General Information
Symbol	Dmel\Tyler	Species	D. melanogaster
Name	Tyler	Annotation symbol	CG14208
Feature type	protein_coding_gene	FlyBase ID	FBgn0031038
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	CG33075
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	18D3-18D3	Sequence location	X:19,505,559..19,509,650 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Tyler is referred to in FlyBase by the symbol Dmel\Tyler (CG14208, FBgn0031038). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transmembrane transporter activity. Based on sequence similarity, it is predicted to be involved in the biological process: transport. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Mitochondrial carrier domain; Mitochondrial substrate/solute carrier. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed during late pupal stages, in adult male stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult Malpighian tubules, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1627973_s_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of Tyler expression signal. See the GBrowse view of Tyler to determine the overlapping gene(s). Gene sequence location is X:19505559..19509650.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 18D3-18D3   Limits computationally determined from genome sequence between P{EP}EP1348&P{EP}e(y)3EP1036 and P{EP}Sec61γEP1511
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tyler for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	gene_with_dicistronic_mRNA ; SO:0000722 Gene model reviewed during 5.43 Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tyler-RB FBtr0074736  NM_134483   2964   441
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tyler-PB   FBpp0074505   48.8   441   9.21     NP_608327   AAN09509
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mitochondrial substrate/solute carrier (IPR018108) Mitochondrial carrier domain (IPR023395)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAN09509   AI389787   AW940808   BF487272   BF492039   BF496754   BF497269   BF501683   BF504554   BF504839   BF506247   BG634172   BT099691   BT126037   BT133468   CO327225   CO327644   EL886610
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IQW4 Q8IQW3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult Malpighian tubules, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    50.675 Larval Midgut    50.5 Larval Hindgut    55.3 Larval Malpighian Tubules    91.4 Larval Fat Body    80.5 Larval Salivary Gland    71 Larval Trachea    44.975 Larval Carcass    52.275 Adult Head    87 Adult Eye    127.225 Adult Brain    121.4 Adult Thoracic-Abdominal Ganglion    122.2 Adult Crop    86.2 Adult Midgut    83.9 Adult Hindgut    96 Adult Malpighian Tubules    232.1 Adult Fat Body    99.2 Adult Salivary Gland    88.4 Adult Heart    54.575 Adult VirginFemale Spermatheca    80.7 Adult InseminatedFemale Spermatheca    91.7 Adult Ovary    112.3 Adult Testis    245.9 Adult Male Accessory Gland    77.6 Adult Carcass    83.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    50.675 Larval Midgut    50.5 Larval Hindgut    55.3 Larval Malpighian Tubules    91.4 Larval Fat Body    80.5 Larval Salivary Gland    71 Larval Trachea    44.975 Larval Carcass    52.275 Adult Head    87 Adult Eye    127.225 Adult Brain    121.4 Adult Thoracic-Abdominal Ganglion    122.2 Adult Crop    86.2 Adult Midgut    83.9 Adult Hindgut    96 Adult Malpighian Tubules    232.1 Adult Fat Body    99.2 Adult Salivary Gland    88.4 Adult Heart    54.575 Adult VirginFemale Spermatheca    80.7 Adult InseminatedFemale Spermatheca    91.7 Adult Ovary    112.3 Adult Testis    245.9 Adult Male Accessory Gland    77.6 Adult Carcass    83.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    50.675 Larval Midgut    50.5 Larval Hindgut    55.3 Larval Malpighian Tubules    91.4 Larval Fat Body    80.5 Larval Salivary Gland    71 Larval Trachea    44.975 Larval Carcass    52.275 Adult Head    87 Adult Eye    127.225 Adult Brain    121.4 Adult Thoracic-Abdominal Ganglion    122.2 Adult Crop    86.2 Adult Midgut    83.9 Adult Hindgut    96 Adult Malpighian Tubules    232.1 Adult Fat Body    99.2 Adult Salivary Gland    88.4 Adult Heart    54.575 Adult VirginFemale Spermatheca    80.7 Adult InseminatedFemale Spermatheca    91.7 Adult Ovary    112.3 Adult Testis    245.9 Adult Male Accessory Gland    77.6 Adult Carcass    83.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    50.675 Larval Midgut    50.5 Larval Hindgut    55.3 Larval Malpighian Tubules    91.4 Larval Fat Body    80.5 Larval Salivary Gland    71 Larval Trachea    44.975 Larval Carcass    52.275 Adult Head    87 Adult Eye    127.225 Adult Brain    121.4 Adult Thoracic-Abdominal Ganglion    122.2 Adult Crop    86.2 Adult Midgut    83.9 Adult Hindgut    96 Adult Malpighian Tubules    232.1 Adult Fat Body    99.2 Adult Salivary Gland    88.4 Adult Heart    54.575 Adult VirginFemale Spermatheca    80.7 Adult InseminatedFemale Spermatheca    91.7 Adult Ovary    112.3 Adult Testis    245.9 Adult Male Accessory Gland    77.6 Adult Carcass    83.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    50.675 Larval Midgut    50.5 Larval Hindgut    55.3 Larval Malpighian Tubules    91.4 Larval Fat Body    80.5 Larval Salivary Gland    71 Larval Trachea    44.975 Larval Carcass    52.275 Adult Head    87 Adult Eye    127.225 Adult Brain    121.4 Adult Thoracic-Abdominal Ganglion    122.2 Adult Crop    86.2 Adult Midgut    83.9 Adult Hindgut    96 Adult Malpighian Tubules    232.1 Adult Fat Body    99.2 Adult Salivary Gland    88.4 Adult Heart    54.575 Adult VirginFemale Spermatheca    80.7 Adult InseminatedFemale Spermatheca    91.7 Adult Ovary    112.3 Adult Testis    245.9 Adult Male Accessory Gland    77.6 Adult Carcass    83.9 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    50.675 Larval Midgut    50.5 Larval Hindgut    55.3 Larval Malpighian Tubules    91.4 Larval Fat Body    80.5 Larval Salivary Gland    71 Larval Trachea    44.975 Larval Carcass    52.275 Adult Head    87 Adult Eye    127.225 Adult Brain    121.4 Adult Thoracic-Abdominal Ganglion    122.2 Adult Crop    86.2 Adult Midgut    83.9 Adult Hindgut    96 Adult Malpighian Tubules    232.1 Adult Fat Body    99.2 Adult Salivary Gland    88.4 Adult Heart    54.575 Adult VirginFemale Spermatheca    80.7 Adult InseminatedFemale Spermatheca    91.7 Adult Ovary    112.3 Adult Testis    245.9 Adult Male Accessory Gland    77.6 Adult Carcass    83.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    50.675 Larval Midgut    50.5 Larval Hindgut    55.3 Larval Malpighian Tubules    91.4 Larval Fat Body    80.5 Larval Salivary Gland    71 Larval Trachea    44.975 Larval Carcass    52.275 Adult Head    87 Adult Eye    127.225 Adult Brain    121.4 Adult Thoracic-Abdominal Ganglion    122.2 Adult Crop    86.2 Adult Midgut    83.9 Adult Hindgut    96 Adult Malpighian Tubules    232.1 Adult Fat Body    99.2 Adult Salivary Gland    88.4 Adult Heart    54.575 Adult VirginFemale Spermatheca    80.7 Adult InseminatedFemale Spermatheca    91.7 Adult Ovary    112.3 Adult Testis    245.9 Adult Male Accessory Gland    77.6 Adult Carcass    83.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    50.675 Larval Midgut    50.5 Larval Hindgut    55.3 Larval Malpighian Tubules    91.4 Larval Fat Body    80.5 Larval Salivary Gland    71 Larval Trachea    44.975 Larval Carcass    52.275 Adult Head    87 Adult Eye    127.225 Adult Brain    121.4 Adult Thoracic-Abdominal Ganglion    122.2 Adult Crop    86.2 Adult Midgut    83.9 Adult Hindgut    96 Adult Malpighian Tubules    232.1 Adult Fat Body    99.2 Adult Salivary Gland    88.4 Adult Heart    54.575 Adult VirginFemale Spermatheca    80.7 Adult InseminatedFemale Spermatheca    91.7 Adult Ovary    112.3 Adult Testis    245.9 Adult Male Accessory Gland    77.6 Adult Carcass    83.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    87   NA  Eye    127.225   NA  Brain    121.4   50.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    122.2   NA  Crop    86.2   50.5  Midgut    83.9   55.3  Hindgut    96   91.4  Malpighian Tubules    232.1   80.5  Fat Body    99.2   71  Salivary Gland    88.4   NA  Heart    54.575   44.975  Trachea    NA   NA  VirginFemale Spermatheca    80.7   NA  InseminatedFemale Spermatheca    91.7   NA  Ovary    112.3   NA  Testis    245.9   NA  Male Accessory Gland    77.6   52.275  Carcass    83.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    4 digestive system, 4-day adult    2 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    7 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    41 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    4 digestive system, 4-day adult    2 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    7 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male  (41) accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    4 digestive system, 4-day adult    2 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    7 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    41 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    4 digestive system, 4-day adult    2 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    7 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    41 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    4 digestive system, 4-day adult    2 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    7 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    41 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    4 digestive system, 4-day adult    2 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    7 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male  (41) accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    4 digestive system, 4-day adult    2 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    7 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    41 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    4 digestive system, 4-day adult    2 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    7 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    41 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed during late pupal stages, in adult male stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    4 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    10 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    12 pupae 3d postWPP    13 pupae 4d postWPP    21 adult male 01day    27 adult male 05day    36 adult male 30day    42 adult female 01day    10 adult female 05day    9 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    4 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    10 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    12 pupae 3d postWPP    13 pupae 4d postWPP    21 adult male 01day  (27) adult male 05day  (36) adult male 30day  (42) adult female 01day    10 adult female 05day    9 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    4 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    10 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    12 pupae 3d postWPP    13 pupae 4d postWPP    21 adult male 01day    27 adult male 05day    36 adult male 30day    42 adult female 01day    10 adult female 05day    9 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    4 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    10 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    12 pupae 3d postWPP    13 pupae 4d postWPP    21 adult male 01day    27 adult male 05day    36 adult male 30day    42 adult female 01day    10 adult female 05day    9 adult female 30day    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    4 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    10 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    12 pupae 3d postWPP    13 pupae 4d postWPP    21 adult male 01day    27 adult male 05day    36 adult male 30day    42 adult female 01day    10 adult female 05day    9 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    4 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    10 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    12 pupae 3d postWPP    13 pupae 4d postWPP    21 adult male 01day  27 adult male 05day  (36) adult male 30day  (42) adult female 01day    10 adult female 05day    9 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    4 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    10 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    12 pupae 3d postWPP    13 pupae 4d postWPP    21 adult male 01day    27 adult male 05day    36 adult male 30day    42 adult female 01day    10 adult female 05day    9 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    4 embryo 04-06hr    4 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    4 embryo 12-14hr    3 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    10 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    12 pupae 3d postWPP    13 pupae 4d postWPP    21 adult male 01day    27 adult male 05day    36 adult male 30day    42 adult female 01day    10 adult female 05day    9 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    10 embryonic Kc167    11 embryonic S1    8 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    6 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    10 embryonic Kc167    11 embryonic S1    8 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    6 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    10 embryonic Kc167    11 embryonic S1    8 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    6 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    10 embryonic Kc167    11 embryonic S1    8 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    6 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    10 embryonic Kc167    11 embryonic S1    8 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    6 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    10 embryonic Kc167    11 embryonic S1    8 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    6 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    10 embryonic Kc167    11 embryonic S1    8 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    6 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    12 embryonic 1182-4H    7 embryonic GM2    10 embryonic Kc167    11 embryonic S1    8 embryonic S3    4 leg disc CME L1    10 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    6 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    5 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult  (31) Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult  31 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_20
External Data & Images
Linkouts	BDGP expression data • GH21048 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031038 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33075-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Tyler Class Mutagen Stocks Known lesion TylerKG09498 1 --
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tyler Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3452} NA P{GD3453} NA P{GD17553} NA P{GD17592} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}TylerKG09498 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
transmembrane transporter activity inferred from sequence or structural similarity (Nelson, 2000.4.10) inferred from sequence or structural similarity with UniProtKB:Q09461 (FlyBase Genome Annotators, 2002-2003)
Biological Process
CV term Evidence References
transport inferred from sequence or structural similarity with UniProtKB:Q09461 (FlyBase Genome Annotators, 2002-2003)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity with UniProtKB:Q09461 (FlyBase Genome Annotators, 2002-2003) mitochondrial envelope inferred from sequence or structural similarity (Nelson, 2000.4.10) inferred from sequence or structural similarity with UniProtKB:Q09461 (FlyBase Genome Annotators, 2002-2003)
Sequence Ontology: Class of Gene
	gene_with_dicistronic_mRNA (FlyBase Genome Annotators, 2002-2003) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tyler allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0031038 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3772349
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PK2V1 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG65X6RW Arthropod inclusive ortholog search EOG698SGG Metazoa inclusive ortholog search EOG6JDW1N
Orthologs in Drosophila Species (EOG6PK2V1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Tyler     Drosophila sechellia   Dsec\GM22971 Y   Drosophila erecta   Dere\GG19235 Y   Drosophila yakuba   Dyak\GE15855 Y   Drosophila ananassae   Dana\GF20409 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA23023 Y   Drosophila persimilis   Dper\GL27056 Y   Drosophila willistoni   Dwil\GK25199 Y   Drosophila virilis   Dvir\GJ15971 Y   Drosophila grimshawi   Dgri\GH24939 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG65X6RW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Ame.3200 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012242 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22506 Y Atta cephalotes Leafcutter ant  Acep\ACEP10612 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19192 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15690 Y Linepithema humile Argentine ant  Lhum\LH23157 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB22991 Y Solenopsis invicta Red fire ant  Sinv\SINV14558 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003858 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007847 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006241 Y Pediculus humanus Human body louse  Phum\PHUM103570 Y Tribolium castaneum Red flour beetle  Tcas\TC000750 Y
Orthologs in non-Insect Arthropods (EOG698SGG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_219561 Y Ixodes scapularis Deer tick  Isca\ISCW008286 Y
Orthologs in non-Arthropod Metazoa (EOG6JDW1N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C16C10.1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016830gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007195gn Y Danio rerio Zebrafish  Drer\slc25a40 Y Danio rerio Zebrafish  Drer\slc25a39 Y Xenopus tropicalis Western clawed frog  Xtro\slc25a39 Y Xenopus tropicalis Western clawed frog  Xtro\slc25a40 Y Gallus gallus Domestic chicken  Ggal\SLC25A39 Y Gallus gallus Domestic chicken  Ggal\SLC25A40 Y Mus musculus House mouse  Mmus\Slc25a39 Y Mus musculus House mouse  Mmus\Slc25a40 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000037910 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000022467 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000032676 Y Rattus norvegicus Norway rat  Rnor\Slc25a40 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000006138 Y Rattus norvegicus Norway rat  Rnor\Slc25a39 Y Homo sapiens Human  Hsap\SLC25A40 Y Homo sapiens Human  Hsap\ENSG00000013306 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\SLC25A40     Hsap\ENSG00000013306
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM22971 Drosophila erecta Dere\GG19235 Drosophila yakuba Dyak\GE15855 Drosophila ananassae Dana\GF20409 Drosophila pseudoobscura pseudoobscura Dpse\GA23023 Drosophila persimilis Dper\GL27056 Drosophila willistoni Dwil\GK25199 Drosophila virilis Dvir\GJ15971 Drosophila mojavensis Dmoj\GI11115 Drosophila grimshawi Dgri\GH24939
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
Bloomington	15190 y1 P{SUPor-P}TylerKG09498
Genomic Clones ( 2 )
	BACR10M08 BACR33M08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 15 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT08524 AT23537
Other clones	FI19922
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT06136 AT06872 AT08675 AT10662 AT11410 AT17078 AT22020 AT28910 AT30289
Other clones	EP06506 EP07806 IP17814
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031038 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3772349
Antibody Information
Other Information
Discoverer
Etymology
	The genes of this dicistronic locus seem to encode mitochondrial transporters, so are named "Tyler" and "Shawn" after two energetic, 9 and 11 year old boys adopted by Chris Smith's parents. Name "Tyler" chosen by Chris Smith to mark his contribution to the FlyBase Release 3 annotation project. (Smith, 2002.10.14)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Tyler CG14208 (Smith, 2002.10.14)
Source for database merge of
Additional comments	Dicistronic annotation CG33075 split out into separate annotations for each open reading frame, CG14208 and CG14209, in release 4.2 of the genome annotation. CG14208 corresponds to Tyler and CG14209 corresponds to Shawn. (FlyBase Genome Annotators, 2005) One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by Tyler and Shawn. (FlyBase Genome Annotators, 2002-2003)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134483 RefSeq (Proteins) • NP_608327 DDBJ / EMBL / GenBank • AAF48981.2 AAF48982.2 AAN09509 AAN09509.1 AAN09510 AAN09510.1 AAN09511.1 AI389787 AW940808 AY070516 Entrez Gene - A searchable database of RefSeq genes. • 7 3772349 UniProtKB/TrEMBL • Q8IQW3 Q8IQW4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mitochondrial substrate/solute carrier (IPR018108) Mitochondrial carrier domain (IPR023395) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH21048
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0031038 DRSC - Results from RNAi screens. • FBgn0031038 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031038 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33075-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031038 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3772349 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3772349 modMine - Data generated by the modENCODE project. • FBgn0031038
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG14208 (Smith, 2002.10.14, Nelson, 2000.4.10, ) CG33075 (Rehwinkel et al., 2006, Gruenewald et al., 2009, Maines et al., 2007, Burgler and Macdonald, 2005) Tyler (Jungreis, 2011.11.18)
Name Synonym	Tyler
Secondary FlyBase IDs
	FBgn0053075
References ( 18 )
Research paper	Gruenewald et al., 2009, Free Radical Biol. Med. 46(12): 1668--1676 Hyperoxia-induced neurodegeneration as a tool to identify neuroprotective genes in Drosophila melanogaster. [FBrf0208024] Maines et al., 2007, Development 134(8): 1471--1479 Stonewalling Drosophila stem cell differentiation by epigenetic controls. [FBrf0200664] Rehwinkel et al., 2006, Mol. Cell. Biol. 26(8): 2965--2975 Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. [FBrf0191204] Burgler and Macdonald, 2005, BMC Genomics 6(1): 88 Prediction and verification of microRNA targets by MovingTargets, a highly adaptable prediction method. [FBrf0187121]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
Personal communication to FlyBase	Jungreis, 2011.11.18, Stop codon readthrough: excluded candidates. Stop codon readthrough: excluded candidates. [FBrf0216885] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Smith, 2002.10.14, Naming a gene - Tyler+Shawn. Naming a gene - Tyler+Shawn. [FBrf0151676] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078] Nelson, 2000.4.10, Mitochondrial carrier genes. Mitochondrial carrier genes. [FBrf0126915]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase Genome Annotators, 2005, Changes affecting gene model number or type in release 4.2 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 4.2 of the annotated D.melanogaster genome. [FBrf0182792] FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705] Ketchum, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126677]