FB2021_01, released Feb 18, 2021

Gene: Dmel\CG14210

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General Information
Symbol
Dmel\CG14210
Species
D. melanogaster
Name
Annotation Symbol
CG14210
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031040
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
18D3-18D3
Sequence location
X:19,616,196..19,616,825 [+]
Recombination map

1-63

RefSeq locus
NC_004354 REGION:19616196..19616825
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in nucleolus
inferred from biological aspect of ancestor with PANTHER:PTN001005466
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in nucleus
inferred from sequence or structural similarity with UniProtKB:Q9H6F5
(FlyBase Curators, 2008--)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CG14210 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG14210-RA
FBtr0074740
NM_134484
567
140
CG14210-RB
FBtr0344070
NM_001298520
559
140
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG14210-PA
FBpp0074509
16.5
140
11.53
NP_608328
AAF48983
CG14210-PB
FBpp0310501
16.5
140
11.53
NP_001285449
AHN59919
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

140 aa isoforms: CG14210-PA, CG14210-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG14210 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG14210 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG14210
Transgenic constructs containing regulatory region of CG14210
Aberrations (Deficiencies and Duplications) ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CCDC86
8 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ccdc86
8 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Ccdc86
7 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\ccdc86
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\si:ch211-217k17.7
8 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\Y40B1B.7
11 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT2G31410
2 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190K2I )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD29006
Drosophila sechellia
Dsec\GM22973
Drosophila erecta
Dere\GG19238
Drosophila yakuba
Dyak\GE15857
Drosophila ananassae
Dana\GF20411
Drosophila pseudoobscura pseudoobscura
Dpse\GA12825
Drosophila persimilis
Dper\GL27058
Drosophila willistoni
Dwil\GK10060
Drosophila virilis
Dvir\GJ15973
Drosophila mojavensis
Dmoj\GI11118
Drosophila grimshawi
Dgri\GH24941
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150GYY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023721
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05317
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000173
Anopheles darlingi
American malaria mosquito
Adar\ADAC000057
Anopheles gambiae
Malaria mosquito
Agam\AGAP004684
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008124
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000736
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0LRD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA013141
Danaus plexippus
Monarch butterfly
Dple\DPOGS201777-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008329
Apis florea
Little honeybee
Aflo\4159718116
Apis mellifera
Western honey bee
Amel\GB49709
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23665
Bombus terrestris
Buff-tailed bumblebee
Bter\15205793
Linepithema humile
Argentine ant
Lhum\LH16430
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002f28
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009549
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10593
Tribolium castaneum
Red flour beetle
Tcas\TC008705
Pediculus humanus
Human body louse
Phum\PHUM214740
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009940
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI088752
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07820
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0LZ7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008822
Ixodes scapularis
Black-legged tick
Isca\ISCW014888
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74308.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_310666
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_95253
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_239967
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CCDC86; coiled-coil domain containing 86
    8 of 15
    611293
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map

        1-63

        Cytogenetic map
        18D3-18D3
        Sequence location
        X:19,616,196..19,616,825 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        18D3-18D3
        Limits computationally determined from genome sequence between P{EP}EP1348&P{EP}e(y)3EP1036 and P{EP}Sec61γEP1511
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        1-63

        (FlyBase, 2016)

        1-62.4

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (5)
        Genomic Clones (5)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (6)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of

          Source for merge of: CG14210 BcDNA:RE23450

          (FlyBase, 1996-)
          Additional comments

          Source for merge of CG14210 BcDNA:RE23450 was TrEMBL update ( date:020807 ).

          (FlyBase, 1996-)
          Other Comments
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 29 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          Synonyms and Secondary IDs (2)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (28)