Arp11
Involved in microtubule-based movement. Predicted to be part of dynactin complex. Is expressed in adult head and adult heart. Orthologous to human ACTR10 (actin related protein 10).
The gene Actin-related protein 10 is referred to in FlyBase by the symbol Dmel\Arp10 (CG12235, FBgn0031050). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (1 unique). Gene sequence location is X:19644531..19646176. Its molecular function is unknown. It is involved in the biological process described with: microtubule-based movement; retrograde axonal transport of mitochondrion. 7 alleles are reported. The phenotype of these alleles manifest in: mesonotum. The phenotypic classes of alleles include: partially lethal - majority die; visible; lethal; abnormal pain response; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.
Please see the JBrowse view of Dmel\Arp10 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.51
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Arp10 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Arp10 in JBrowseThe gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.
Category | Common alleles (# stocks) |
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Classical and Insertion Alleles | |
Loss of function allele | |
Amorphic allele | |
Fluorescently-tagged allele | |
Transgenic Constructs | |
UAS RNAi | |
UAS wild-type cDNA | |
Untagged genomic rescue | |
Fluorescently-tagged genomic rescue | |
Aberrations | |
Deficiency | |
Duplication |
1-63
1-62.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Source for identity of: Arp11 CG12235
Source for identity of: Arp10 Arp11
'Arp11' renamed to 'Arp10' to rationalize the nomenclature of Actin-related protein (Arp) genes (by orthology with the mammalian and yeast genes). This gene was originally referred to as 'ARP11' in FBrf0132100, but there is no yeast or mammalian gene with this symbol. However, 'Arp11' is a synonym for the human 'actin-related protein 10 homolog' gene, and the computed vertebrate orthologs of the D. melanogaster gene (CG12235) are all 'ARP10' genes.