FlyBase Gene Report: Dmel\COX6B

General Information

Symbol

Dmel\COX6B

Species

D. melanogaster

Name

Cytochrome c oxidase subunit 6B

Annotation Symbol

CG14235

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031066

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Cytochrome c oxidase subunit VIb, CoVIb

Key Links

Genomic Location

Cytogenetic map

18E5-18E5

Sequence location

X:19,740,537..19,744,335 [-]

Recombination map

1-64

RefSeq locus

NC_004354 REGION:19740537..19744335

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in mitochondrial cytochrome c oxidase assembly

inferred from sequence or structural similarity with SGD:S000004028

(Gene Ontology Curators, 2002-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in mitochondrial inner membrane

inferred from direct assay

(Brischigliaro et al., 2022)

located_in mitochondrion

inferred from direct assay

(Ren et al., 2010)

part_of respiratory chain complex IV

inferred from direct assay

(Brischigliaro et al., 2022)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN000147427

(GO Reference Genome Project, 2011-)

located_in mitochondrion

inferred from electronic annotation with InterPro:IPR003213, InterPro:IPR036549

(InterPro Project Members, 2004-)

part_of respiratory chain complex IV

non-traceable author statement

(Porcelli et al., 2007)

inferred from sequence or structural similarity with SGD:S000004028

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR003213

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX IV - SUPERNUMERARY SUBUNITS

MITOCHONDRIAL COMPLEX IV - TESTIS-SPECIFIC VARIANT

MITOCHONDRIAL COMPLEX IV

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX IV - SUPERNUMERARY SUBUNITS -: Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. Eukaryotic COX is a multimeric enzyme formed by subunits of dual genetic origin. The three subunits forming the catalytic core of the enzyme (COX1, COX2 and COX3) are encoded by the mitochondrial DNA. The non-catalytic subunits are all encoded by the nuclear DNA. The functions of these 'supernumerary subunits' are largely unknown, though are assumed to regulate complex IV activity and to coordinate energy production with cellular needs. (Adapted from PMID:17091399 and PMID:28870773.)
MITOCHONDRIAL COMPLEX IV - TESTIS-SPECIFIC VARIANT -: Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. (Adapted from PMID:17091399 and PMID:28870773.)
MITOCHONDRIAL COMPLEX IV -: Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. (Adapted from PMID:17091399 and PMID:28870773.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\COX6B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VWD1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Shares 5' UTR with upstream gene.

Gene model reviewed during 5.39

Gene model reviewed during 5.45

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0074815

740

FBtr0074817

554

FBtr0074816

706

FBtr0308683

678

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

COX6B-PA

FBpp0074584

11.4

8.90

FBpp0074586

9.3

8.62

FBpp0074585

9.3

8.62

FBpp0300889

9.3

8.62

Q8IQW2

NP_001245767

AFH07479

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

77 aa isoforms: COX6B-PB, COX6B-PC, COX6B-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\COX6B using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CoVIb_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.72

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in mitochondrial inner membrane

inferred from direct assay

(Brischigliaro et al., 2022)

located_in mitochondrion

inferred from direct assay

(Ren et al., 2010)

part_of respiratory chain complex IV

inferred from direct assay

(Brischigliaro et al., 2022)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\COX6B in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\COX6B

View exonic expression by tissue for Dmel\COX6B

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32989/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031066

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031066

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031066

Flygut - An atlas of the Drosophila adult midgut

FBgn0031066

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of COX6B

Transgenic constructs containing regulatory region of COX6B

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)Exel6253

(Ryder, 2004.4.26)

Inferred from location ( 20 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^insc-Mz1407

COX6B^GD13061

lethal - all die during larval stage, with Scer\GAL4^da.PU

COX6B^GD13061

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

COX6B^GD13061

lethal - all die during P-stage, with Scer\GAL4^G14

COX6B^GD13061

partially lethal - majority die, with Scer\GAL4^pnr-MD237

COX6B^GD13061

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

COX6B^GD13061

viable, with Scer\GAL4^C57

COX6B^GD13061

viable, with Scer\GAL4^Ddc.PL

COX6B^GD13061

viable, with Scer\GAL4^elav.PLu

COX6B^GD13061

viable, with Scer\GAL4^nrv2.PS

COX6B^GD13061

viable, with Scer\GAL4^smid-C161

COX6B^GD13061

viable, with Scer\GAL4^tin.CΔ4

COX6B^GD13061

viable, with Scer\GAL4^VGlut1-OK371

COX6B^GD13061

Other Phenotypes

Allele

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

COX6B^GD13061

some die during pupal stage, with Scer\GAL4^pnr-MD237

COX6B^GD13061

visible, with Scer\GAL4^pnr-MD237

COX6B^GD13061

Phenotype manifest in

Allele

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

COX6B^GD13061

mesonotum, with Scer\GAL4^pnr-MD237

COX6B^GD13061

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

Hsap\COX6B1

12 of 14

Yes

Hsap\COX6B2

9 of 14

Yes

Hsap\COA6

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

Rnor\Cox6b1

13 of 14

Yes

Rnor\Cox6b2

12 of 14

Yes

Rnor\Coa6

1 of 14

Mus musculus (laboratory mouse) (3)

Mmus\Cox6b1

13 of 14

Yes

Mmus\Cox6b2

11 of 14

Yes

Mmus\Coa6

2 of 14

Xenopus tropicalis (Western clawed frog) (2)

Xtro\cox6b1

7 of 13

Yes

Xtro\nit1

5 of 13

Danio rerio (Zebrafish) (3)

Drer\cox6b1

14 of 14

Yes

Drer\cox6b2

13 of 14

Yes

Drer\coa6

2 of 14

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\cox-6B

12 of 14

Yes

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP013092

12 of 12

Yes

Agam\AgaP_AGAP013542

1 of 12

Arabidopsis thaliana (thale-cress) (4)

Atha\AT4G28060

11 of 13

Yes

Atha\AT5G57815

11 of 13

Yes

Atha\COX6B

9 of 13

Yes

Atha\AT1G32710

4 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\COX12

12 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cox12

11 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:COX6B. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

CG42376

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

COX6B1; cytochrome c oxidase subunit 6B1

model of mitochondrial complex IV deficiency nuclear type 7

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

COX6B1; cytochrome c oxidase subunit 6B1

12 of 14

124089

MITOCHONDRIAL COMPLEX IV DEFICIENCY, NUCLEAR TYPE 7; MC4DN7

mitochondrial complex IV deficiency nuclear type 7

COX6B2; cytochrome c oxidase subunit 6B2

9 of 14

618127

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

COX6B - COX4

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

COX6B - COX5A

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

COX6B - COX5B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX6B - COX7A

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX6B - COX7AL2

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX6B - COX7B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX6B - COX8

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX6B - ND-MLRQ

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

COX6B - cype

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

COX6B - levy

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

COX6B - mt:CoI

blue native page, peptide massfingerprinting, cosedimentation

(Brischigliaro et al., 2022, Rahman et al., 2014)

COX6B - mt:CoII

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

COX6B - mt:CoIII

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59284

DroID - A comprehensive database of gene and protein interactions.

FBgn0031066

MIST (protein-protein) - An integrated Molecular Interaction Database

32989

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-64

Cytogenetic map

18E5-18E5

Sequence location

X:19,740,537..19,744,335 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

18E5-18E5

Limits computationally determined from genome sequence between P{EP}Sec61γ^EP1511 and P{EP}EP1116&P{EP}EP1344^EP1344

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-64

(FlyBase, 2016)

1-62.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18726

w¹¹¹⁸ PBac{WH}COX6B^f04041/FM7c

79837

y¹ sc^* v¹ sev²¹; P{TOE.GS02530}attP40

26630

w^* P{EP}COX6B^G11337 CG18809^G11337/FM6, w^*

VDRC

v26848

w¹¹¹⁸; P{GD13061}v26848

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (136)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031066

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031066

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Ren et al., 2010)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

One or more of the processed transcripts for this gene share(s) untranslated sequences with a transcript of an adjacent gene, but encode(s) a single open reading frame (ORF). The non-overlapping ORFs that share untranslated sequences are represented by CG14235 and CG18809.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: CoVIb CG14235

(Ren et al., 2010)

Source for identity of: COX6B CoVIb

(Porcelli and Marygold, 2014.9.16)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CG14235

(Curcio et al., 2024, Aradska et al., 2015, Foriel et al., 2015, Hosono et al., 2015, Kemppainen et al., 2014, Kwon et al., 2013, Jaspers et al., 2012, Cammarato et al., 2011, Friedman et al., 2011, Ladoukakis et al., 2011, Müller et al., 2010, Porcelli et al., 2010, Wasbrough et al., 2010, Chen et al., 2008, Porcelli et al., 2007, Caggese et al., 2006)

COX6B

(Curcio et al., 2024, Dorogova et al., 2023, Nozawa et al., 2023, Ren et al., 2023, Brischigliaro et al., 2022, Sen and Cox, 2022, Pang et al., 2021, Transgenic RNAi Project members, 2017-, Zhang et al., 2016, Porcelli and Marygold, 2014.9.16)

COXG

(Caggese et al., 2006)

CcoVIb

(Peng et al., 2011)

CoVIb

(Kemppainen et al., 2014)

Cox6b

(Kemppainen et al., 2014)

Q8IQW2

(Ebanks et al., 2021)

VIb

(Ren et al., 2010)

vib

(Okamoto et al., 2018)

Name Synonyms

Cytochrome c oxidase Polypeptide VIb

(Tripoli et al., 2005)

Cytochrome c oxidase VIb

(Porcelli et al., 2007)

Cytochrome c oxidase polypeptide VIb

(Caggese et al., 2006)

Cytochrome c oxidase subunit 6B

(Porcelli and Marygold, 2014.9.16)

Cytochrome c oxidase subunit VIb

(Peng et al., 2011)

Cytochrome c oxidase subunitVIb

(Kang et al., 2002)

Subunit VIb

(Ren et al., 2010)

Secondary FlyBase IDs

FBgn0064130

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32989

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VWD1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VWD1

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32989/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031066

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031066

FlyMine - An integrated database for Drosophila genomics

FBgn0031066

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG14235

MARRVEL_MODEL - MARRVEL (model organism gene)

32989

Linkouts

BioGRID - A database of protein and genetic interactions.

59284

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031066

DroID - A comprehensive database of gene and protein interactions.

FBgn0031066

DRSC - Results frm RNAi screens

FBgn0031066

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CoVIb_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031066

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031066

Flygut - An atlas of the Drosophila adult midgut

FBgn0031066

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0031066

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031023

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

32989

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (65)

The following external sites may use different assemblies or annotations than FlyBase.

-0.72

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