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Gene Dmel\HERC2

General Information
Symbol	Dmel\HERC2	Species	D. melanogaster
Name	HERC2	Annotation symbol	CG11734
Feature type	protein_coding_gene	FlyBase ID	FBgn0031107
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	19C6-19C6	Sequence location	X:20,265,505..20,283,274 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene HERC2 is referred to in FlyBase by the symbol Dmel\HERC2 (CG11734, FBgn0031107). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: ubiquitin-protein ligase activity; guanyl-nucleotide exchange factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: protein ubiquitination. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Anaphase-promoting complex, subunit 10/DOC domain; CPH domain; CUB; Cytochrome b5; Galactose-binding domain-like; HECT; Mib-herc2; Regulator of chromosome condensation, RCC1; Regulator of chromosome condensation/beta-lactamase-inhibitor protein II; Translation protein SH3-like, subgroup; UBA-like; Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval hindgut, adult fat body, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1629145_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of HERC2. Gene sequence location is X:20265505..20283274.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA20566 BKN20277
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 19C6-19C6   Limits computationally determined from genome sequence between P{EP}amnEP1639&P{EP}amnEP367 and P{EP}CG1702EP1525
Experimentally Determined Cytological Location
Cytogenetic map Notes References 19C-19E     (Ji, 1999.9.22)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\HERC2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Possible mutation in sequenced strain: transposon inserted in first intron. DGC clone appears problematic: incomplete CDS, contains transposon sequences
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) HERC2-RC FBtr0301344  NM_134544   15834   4912
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein HERC2-PC   FBpp0290558   530.0   4912   6.87     NP_608388   AAF50913
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (IPR015940) Regulator of chromosome condensation, RCC1 (IPR000408) HECT (IPR000569) Cytochrome b5 (IPR001199) Regulator of chromosome condensation/beta-lactamase-inhibitor protein II (IPR009091) Mib-herc2 (IPR010606) CUB (IPR000859) Galactose-binding domain-like (IPR008979) Anaphase-promoting complex, subunit 10/DOC domain (IPR004939) CPH domain (IPR021097) UBA-like (IPR009060) Translation protein SH3-like, subgroup (IPR014722)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567486   AE014298 AAF50913   AF189221 AAF61856   AY113293 AAM29298   BF487751   BI234052   BI577037   BI590270   BI618651   CO275665   CO281582   CO291993   CO301407   CO326773   CO339490   EC052253   EC052460   EC054917   EC084904   EC221049   EC235530   EC239300   EC239313   EC251739   EC254134   EV576790   EW712782   EW713006   FL502447   GH741321   GH741502   GH742387   GH742520   GH746373   GH761815   GH764853   GH767770   GH768089   GH769449
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VR91
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031107    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031107 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031107 expression level Developmental Stage   Expression Level embryo 00-02hr    1423 embryo 02-04hr    1054 embryo 04-06hr    1499 embryo 06-08hr    1585 embryo 08-10hr    1158 embryo 10-12hr    973 embryo 12-14hr    793 embryo 14-16hr    1114 embryo 16-18hr    723 embryo 18-20hr    714 embryo 20-22hr    558 embryo 22-24hr    412 larva L1    656 larva L2    399 larva L3 12hr old    384 larva L3 puffstage 1-2    290 larva L3 puffstage 3-6    607 larva L3 puffstage 7-9    454 white prepupae new    535 white prepupae 12hr    644 white prepupae 24hr    1020 pupae 2d postWPP    613 pupae 3d postWPP    474 pupae 4d postWPP    537 adult male 01day    810 adult male 05day    1024 adult male 30day    1023 adult female 01day    935 adult female 05day    908 adult female 30day    966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1423) embryo 02-04hr  (1054) embryo 04-06hr  (1499) embryo 06-08hr  (1585) embryo 08-10hr  (1158) embryo 10-12hr  (973) embryo 12-14hr  (793) embryo 14-16hr  (1114) embryo 16-18hr  (723) embryo 18-20hr  (714) embryo 20-22hr  (558) embryo 22-24hr  (412) larva L1  (656) larva L2  (399) larva L3 12hr old  (384) larva L3 puffstage 1-2  (290) larva L3 puffstage 3-6  (607) larva L3 puffstage 7-9  (454) white prepupae new  (535) white prepupae 12hr  (644) white prepupae 24hr  (1020) pupae 2d postWPP  (613) pupae 3d postWPP  (474) pupae 4d postWPP  (537) adult male 01day  (810) adult male 05day  (1024) adult male 30day  (1023) adult female 01day  (935) adult female 05day  (908) adult female 30day  (966) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1423 embryo 02-04hr    1054 embryo 04-06hr  1499 embryo 06-08hr  (1585) embryo 08-10hr    1158 embryo 10-12hr    973 embryo 12-14hr    793 embryo 14-16hr    1114 embryo 16-18hr    723 embryo 18-20hr    714 embryo 20-22hr    558 embryo 22-24hr    412 larva L1    656 larva L2    399 larva L3 12hr old    384 larva L3 puffstage 1-2    290 larva L3 puffstage 3-6    607 larva L3 puffstage 7-9    454 white prepupae new    535 white prepupae 12hr    644 white prepupae 24hr    1020 pupae 2d postWPP    613 pupae 3d postWPP    474 pupae 4d postWPP    537 adult male 01day    810 adult male 05day    1024 adult male 30day    1023 adult female 01day    935 adult female 05day    908 adult female 30day    966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1423 embryo 02-04hr    1054 embryo 04-06hr    1499 embryo 06-08hr    1585 embryo 08-10hr    1158 embryo 10-12hr    973 embryo 12-14hr    793 embryo 14-16hr    1114 embryo 16-18hr    723 embryo 18-20hr    714 embryo 20-22hr    558 embryo 22-24hr    412 larva L1    656 larva L2    399 larva L3 12hr old    384 larva L3 puffstage 1-2    290 larva L3 puffstage 3-6    607 larva L3 puffstage 7-9    454 white prepupae new    535 white prepupae 12hr    644 white prepupae 24hr    1020 pupae 2d postWPP    613 pupae 3d postWPP    474 pupae 4d postWPP    537 adult male 01day    810 adult male 05day    1024 adult male 30day    1023 adult female 01day    935 adult female 05day    908 adult female 30day    966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1423 embryo 02-04hr    1054 embryo 04-06hr    1499 embryo 06-08hr    1585 embryo 08-10hr    1158 embryo 10-12hr    973 embryo 12-14hr    793 embryo 14-16hr    1114 embryo 16-18hr    723 embryo 18-20hr    714 embryo 20-22hr    558 embryo 22-24hr    412 larva L1    656 larva L2    399 larva L3 12hr old    384 larva L3 puffstage 1-2    290 larva L3 puffstage 3-6    607 larva L3 puffstage 7-9    454 white prepupae new    535 white prepupae 12hr    644 white prepupae 24hr    1020 pupae 2d postWPP    613 pupae 3d postWPP    474 pupae 4d postWPP    537 adult male 01day    810 adult male 05day    1024 adult male 30day    1023 adult female 01day    935 adult female 05day    908 adult female 30day    966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031107 expression level Developmental Stage   Expression Level embryo 00-02hr    1423 embryo 02-04hr    1054 embryo 04-06hr    1499 embryo 06-08hr    1585 embryo 08-10hr    1158 embryo 10-12hr    973 embryo 12-14hr    793 embryo 14-16hr    1114 embryo 16-18hr    723 embryo 18-20hr    714 embryo 20-22hr    558 embryo 22-24hr    412 larva L1    656 larva L2    399 larva L3 12hr old    384 larva L3 puffstage 1-2    290 larva L3 puffstage 3-6    607 larva L3 puffstage 7-9    454 white prepupae new    535 white prepupae 12hr    644 white prepupae 24hr    1020 pupae 2d postWPP    613 pupae 3d postWPP    474 pupae 4d postWPP    537 adult male 01day    810 adult male 05day    1024 adult male 30day    1023 adult female 01day    935 adult female 05day    908 adult female 30day    966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1423) embryo 02-04hr  (1054) embryo 04-06hr  (1499) embryo 06-08hr  (1585) embryo 08-10hr  (1158) embryo 10-12hr  (973) embryo 12-14hr  (793) embryo 14-16hr  (1114) embryo 16-18hr  (723) embryo 18-20hr  (714) embryo 20-22hr  (558) embryo 22-24hr  (412) larva L1  (656) larva L2  (399) larva L3 12hr old  (384) larva L3 puffstage 1-2  (290) larva L3 puffstage 3-6  (607) larva L3 puffstage 7-9  (454) white prepupae new  (535) white prepupae 12hr  (644) white prepupae 24hr  (1020) pupae 2d postWPP  (613) pupae 3d postWPP  (474) pupae 4d postWPP  (537) adult male 01day  (810) adult male 05day  (1024) adult male 30day  (1023) adult female 01day  (935) adult female 05day  (908) adult female 30day  (966) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1423 embryo 02-04hr    1054 embryo 04-06hr  1499 embryo 06-08hr  1585 embryo 08-10hr    1158 embryo 10-12hr    973 embryo 12-14hr    793 embryo 14-16hr    1114 embryo 16-18hr    723 embryo 18-20hr    714 embryo 20-22hr    558 embryo 22-24hr    412 larva L1    656 larva L2    399 larva L3 12hr old    384 larva L3 puffstage 1-2    290 larva L3 puffstage 3-6    607 larva L3 puffstage 7-9    454 white prepupae new    535 white prepupae 12hr    644 white prepupae 24hr    1020 pupae 2d postWPP    613 pupae 3d postWPP    474 pupae 4d postWPP    537 adult male 01day    810 adult male 05day    1024 adult male 30day    1023 adult female 01day    935 adult female 05day    908 adult female 30day    966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1423 embryo 02-04hr    1054 embryo 04-06hr    1499 embryo 06-08hr    1585 embryo 08-10hr    1158 embryo 10-12hr    973 embryo 12-14hr    793 embryo 14-16hr    1114 embryo 16-18hr    723 embryo 18-20hr    714 embryo 20-22hr    558 embryo 22-24hr    412 larva L1    656 larva L2    399 larva L3 12hr old    384 larva L3 puffstage 1-2    290 larva L3 puffstage 3-6    607 larva L3 puffstage 7-9    454 white prepupae new    535 white prepupae 12hr    644 white prepupae 24hr    1020 pupae 2d postWPP    613 pupae 3d postWPP    474 pupae 4d postWPP    537 adult male 01day    810 adult male 05day    1024 adult male 30day    1023 adult female 01day    935 adult female 05day    908 adult female 30day    966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1423 embryo 02-04hr    1054 embryo 04-06hr    1499 embryo 06-08hr    1585 embryo 08-10hr    1158 embryo 10-12hr    973 embryo 12-14hr    793 embryo 14-16hr    1114 embryo 16-18hr    723 embryo 18-20hr    714 embryo 20-22hr    558 embryo 22-24hr    412 larva L1    656 larva L2    399 larva L3 12hr old    384 larva L3 puffstage 1-2    290 larva L3 puffstage 3-6    607 larva L3 puffstage 7-9    454 white prepupae new    535 white prepupae 12hr    644 white prepupae 24hr    1020 pupae 2d postWPP    613 pupae 3d postWPP    474 pupae 4d postWPP    537 adult male 01day    810 adult male 05day    1024 adult male 30day    1023 adult female 01day    935 adult female 05day    908 adult female 30day    966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031107    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031107 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval hindgut, adult fat body, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031107 expression level Tissue   Expression Level Larval Central Nervous System    279.5 Larval Midgut    82.1 Larval Hindgut    103.6 Larval Malpighian Tubules    93.8 Larval Fat Body    64.7 Larval Salivary Gland    90.9 Larval Trachea    87.025 Larval Carcass    74.65 Adult Head    123.1 Adult Eye    126.825 Adult Brain    355.5 Adult Thoracic-Abdominal Ganglion    270.5 Adult Crop    62.1 Adult Midgut no informative data Adult Hindgut    71.9 Adult Malpighian Tubules    58.4 Adult Fat Body    120.6 Adult Salivary Gland    81.7 Adult Heart    70.475 Adult VirginFemale Spermatheca    64 Adult InseminatedFemale Spermatheca    62.3 Adult Ovary    137.6 Adult Testis    46.7 Adult Male Accessory Gland    73.6 Adult Carcass    82 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    279.5 Larval Midgut    82.1 Larval Hindgut    103.6 Larval Malpighian Tubules    93.8 Larval Fat Body    64.7 Larval Salivary Gland    90.9 Larval Trachea    87.025 Larval Carcass    74.65 Adult Head    123.1 Adult Eye    126.825 Adult Brain    355.5 Adult Thoracic-Abdominal Ganglion    270.5 Adult Crop    62.1 Adult Midgut no informative data Adult Hindgut    71.9 Adult Malpighian Tubules    58.4 Adult Fat Body    120.6 Adult Salivary Gland    81.7 Adult Heart    70.475 Adult VirginFemale Spermatheca    64 Adult InseminatedFemale Spermatheca    62.3 Adult Ovary    137.6 Adult Testis    46.7 Adult Male Accessory Gland    73.6 Adult Carcass    82 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    279.5 Larval Midgut    82.1 Larval Hindgut    103.6 Larval Malpighian Tubules    93.8 Larval Fat Body    64.7 Larval Salivary Gland    90.9 Larval Trachea    87.025 Larval Carcass    74.65 Adult Head    123.1 Adult Eye    126.825 Adult Brain    355.5 Adult Thoracic-Abdominal Ganglion    270.5 Adult Crop    62.1 Adult Midgut no informative data Adult Hindgut    71.9 Adult Malpighian Tubules    58.4 Adult Fat Body    120.6 Adult Salivary Gland    81.7 Adult Heart    70.475 Adult VirginFemale Spermatheca    64 Adult InseminatedFemale Spermatheca    62.3 Adult Ovary    137.6 Adult Testis    46.7 Adult Male Accessory Gland    73.6 Adult Carcass    82 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    279.5 Larval Midgut    82.1 Larval Hindgut    103.6 Larval Malpighian Tubules    93.8 Larval Fat Body    64.7 Larval Salivary Gland    90.9 Larval Trachea    87.025 Larval Carcass    74.65 Adult Head    123.1 Adult Eye    126.825 Adult Brain    355.5 Adult Thoracic-Abdominal Ganglion    270.5 Adult Crop    62.1 Adult Midgut no informative data Adult Hindgut    71.9 Adult Malpighian Tubules    58.4 Adult Fat Body    120.6 Adult Salivary Gland    81.7 Adult Heart    70.475 Adult VirginFemale Spermatheca    64 Adult InseminatedFemale Spermatheca    62.3 Adult Ovary    137.6 Adult Testis    46.7 Adult Male Accessory Gland    73.6 Adult Carcass    82 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031107 expression level Tissue   Expression Level Larval Central Nervous System    279.5 Larval Midgut    82.1 Larval Hindgut    103.6 Larval Malpighian Tubules    93.8 Larval Fat Body    64.7 Larval Salivary Gland    90.9 Larval Trachea    87.025 Larval Carcass    74.65 Adult Head    123.1 Adult Eye    126.825 Adult Brain    355.5 Adult Thoracic-Abdominal Ganglion    270.5 Adult Crop    62.1 Adult Midgut no informative data Adult Hindgut    71.9 Adult Malpighian Tubules    58.4 Adult Fat Body    120.6 Adult Salivary Gland    81.7 Adult Heart    70.475 Adult VirginFemale Spermatheca    64 Adult InseminatedFemale Spermatheca    62.3 Adult Ovary    137.6 Adult Testis    46.7 Adult Male Accessory Gland    73.6 Adult Carcass    82 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    279.5 Larval Midgut    82.1 Larval Hindgut    103.6 Larval Malpighian Tubules    93.8 Larval Fat Body    64.7 Larval Salivary Gland    90.9 Larval Trachea    87.025 Larval Carcass    74.65 Adult Head    123.1 Adult Eye    126.825 Adult Brain    355.5 Adult Thoracic-Abdominal Ganglion    270.5 Adult Crop    62.1 Adult Midgut no informative data Adult Hindgut    71.9 Adult Malpighian Tubules    58.4 Adult Fat Body    120.6 Adult Salivary Gland    81.7 Adult Heart    70.475 Adult VirginFemale Spermatheca    64 Adult InseminatedFemale Spermatheca    62.3 Adult Ovary    137.6 Adult Testis    46.7 Adult Male Accessory Gland    73.6 Adult Carcass    82 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    279.5 Larval Midgut    82.1 Larval Hindgut    103.6 Larval Malpighian Tubules    93.8 Larval Fat Body    64.7 Larval Salivary Gland    90.9 Larval Trachea    87.025 Larval Carcass    74.65 Adult Head    123.1 Adult Eye    126.825 Adult Brain    355.5 Adult Thoracic-Abdominal Ganglion    270.5 Adult Crop    62.1 Adult Midgut no informative data Adult Hindgut    71.9 Adult Malpighian Tubules    58.4 Adult Fat Body    120.6 Adult Salivary Gland    81.7 Adult Heart    70.475 Adult VirginFemale Spermatheca    64 Adult InseminatedFemale Spermatheca    62.3 Adult Ovary    137.6 Adult Testis    46.7 Adult Male Accessory Gland    73.6 Adult Carcass    82 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    279.5 Larval Midgut    82.1 Larval Hindgut    103.6 Larval Malpighian Tubules    93.8 Larval Fat Body    64.7 Larval Salivary Gland    90.9 Larval Trachea    87.025 Larval Carcass    74.65 Adult Head    123.1 Adult Eye    126.825 Adult Brain    355.5 Adult Thoracic-Abdominal Ganglion    270.5 Adult Crop    62.1 Adult Midgut no informative data Adult Hindgut    71.9 Adult Malpighian Tubules    58.4 Adult Fat Body    120.6 Adult Salivary Gland    81.7 Adult Heart    70.475 Adult VirginFemale Spermatheca    64 Adult InseminatedFemale Spermatheca    62.3 Adult Ovary    137.6 Adult Testis    46.7 Adult Male Accessory Gland    73.6 Adult Carcass    82 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    123.1   NA  Eye    126.825   NA  Brain    355.5   279.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    270.5   NA  Crop    62.1   82.1  Midgut    no informative data   103.6  Hindgut    71.9   93.8  Malpighian Tubules    58.4   64.7  Fat Body    120.6   90.9  Salivary Gland    81.7   NA  Heart    70.475   87.025  Trachea    NA   NA  VirginFemale Spermatheca    64   NA  InseminatedFemale Spermatheca    62.3   NA  Ovary    137.6   NA  Testis    46.7   NA  Male Accessory Gland    73.6   74.65  Carcass    82 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031107 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11734-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 HERC2GD5225 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of HERC2 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of HERC2 Class Mutagen Stocks Known lesion HERC2GD5225 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes HERC2KK100181 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6254 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5225} NA P{KK100181} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
guanyl-nucleotide exchange factor activity non-traceable author statement (Ji, 1999.9.22) heme binding inferred from electronic annotation with InterPro:IPR001199 (FlyBase Curators et al., 2004-) ubiquitin-protein ligase activity inferred from electronic annotation with InterPro:IPR010606 (FlyBase Curators et al., 2004-) non-traceable author statement (Ji, 1999.9.22)
Biological Process
CV term Evidence References
protein ubiquitination inferred from electronic annotation with InterPro:IPR010606 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR000569 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions HERC2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59326 DroID - A comprehensive database of gene and protein interactions. • FBgn0031107 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33035
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19414 Dere\GG19286 Dgri\GH17927 Dmoj\GI16306 Dpse\GA11166 Dsim\GD17489 Dvir\GJ15642 Dwil\GK20144
Curated drosophilid orthologs	Dmir\CG11734 (Thornton, 2005.12.20) Dpse\GA11166
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11176 LH19609 LH19608 ISCW015621 ISCW015619 FBgn0235315 FBgn0235314 FBgn0235313 FBgn0222141 FBgn0202832 FBgn0189041 FBgn0177896 FBgn0177895 JGI_V11_50378 FBgn0071221 FBgn0164420 FBgn0164419 FBgn0139054 FBgn0125395 FBgn0111490 FBgn0096423 CPIJ011294 BGIBMGA007894 BGIBMGA007893 ACYPI28141 ACYPI008605 GB12099 AGAP011823 AAEL002306 PB24388 PB24389 PHUM338390 GLEAN_16227 GLEAN_16228
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
VDRC	v105374 P{KK100181}VIE-260B v15486 w1118 P{GD5225}v15486 v45302 w1118; P{GD5225}v45302 v45303 w1118; P{GD5225}v45303
Genomic Clones ( 1 )
	BACR30J04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 35 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT22791
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL01334 RE29682 RH03864 RH33796 RH49529
Other clones	14992 42886 71230 189980 190202 214289.66 214577.43 Dmel_dig_013376_0663_1782 DMG1-chrX.21.024.a DMG4-chrX.36.020.pred.a EC052253 EC052460 EC054917 EK118218 EK157530 EK180908 EK198946 EP02119 EP04614 RP001006602 RP001008875 RP001015943 RP001016239 RP001017845 RP001018456 RP001024815 RP001026256 RP001033204 RP001054206
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031107 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33035
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: HERC2 CG11734 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of HERC2 CG11734 was sequence comparison (date:000407). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134544 RefSeq (Proteins) • NP_608388 DDBJ / EMBL / GenBank • AAF50913 AAF61856 AAM29298 AF189221 AY113293 BF487751 Entrez Gene - A searchable database of RefSeq genes. • 33035 UniProtKB/TrEMBL • Q9VR91
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (IPR015940) Regulator of chromosome condensation, RCC1 (IPR000408) HECT (IPR000569) Cytochrome b5 (IPR001199) Regulator of chromosome condensation/beta-lactamase-inhibitor protein II (IPR009091) Mib-herc2 (IPR010606) CUB (IPR000859) Galactose-binding domain-like (IPR008979) Anaphase-promoting complex, subunit 10/DOC domain (IPR004939) CPH domain (IPR021097) UBA-like (IPR009060) Translation protein SH3-like, subgroup (IPR014722)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59326 DroID - A comprehensive database of gene and protein interactions. • FBgn0031107 DRSC - Results from RNAi screens. • FBgn0031107 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031107 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11734-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031107 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33035 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33035 modMine - Data generated by the modENCODE project. • FBgn0031107 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11176 LH19609 LH19608 ISCW015621 ISCW015619 FBgn0235315 FBgn0235314 FBgn0235313 FBgn0222141 FBgn0202832 FBgn0189041 FBgn0177896 FBgn0177895 JGI_V11_50378 FBgn0071221 FBgn0164420 FBgn0164419 FBgn0139054 FBgn0125395 FBgn0111490 FBgn0096423 CPIJ011294 BGIBMGA007894 BGIBMGA007893 ACYPI28141 ACYPI008605 GB12099 AGAP011823 AAEL002306 PB24388 PB24389 PHUM338390 GLEAN_16227 GLEAN_16228
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG11734 (Keleman et al., 2009.8.5) HERC2 (Levine and Begun, 2008, Martin et al., 2007)
Name Synonym	HERC2
Secondary FlyBase IDs
References ( 17 )
Research paper	Levine and Begun, 2008, Genetics 179(1): 475--485 Evidence of spatially varying selection acting on four chromatin-remodeling loci in Drosophila melanogaster. [FBrf0205278] Martin et al., 2007, Cell Death Diffn 14(5): 916--923 Proteomic analysis of steroid-triggered autophagic programmed cell death during Drosophila development. [FBrf0200796] Ashburner, 2000, Genome Res. 10(4): 391--393 A Biologist's view of the Drosophila genome annotation assessment project. [FBrf0126992]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Thornton, 2005.12.20, GenBank/EMBL/DDBJ: DQ334072 Drosophila miranda CG11734 gene, partial cds. [FBrf0197681] Ji, 1999.9.22, GenBank/EMBL/DDBJ: AF189221 Drosophila melanogaster HERC2 (HERC2) mRNA, partial cds. [FBrf0127922]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Li, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126682]