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Gene Dmel\cactin

General Information
Symbol	Dmel\cactin	Species	D. melanogaster
Name	cactin	Annotation symbol	CG1676
Feature type	protein_coding_gene	FlyBase ID	FBgn0031114
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	19D1-19D1	Sequence location	X:20,295,007..20,297,429 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cactin is referred to in FlyBase by the symbol Dmel\cactin (CG1676, FBgn0031114). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: dorsal/ventral axis specification; neurogenesis. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cactin protein, cactus-binding domain, C-terminal; Cactin, domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1634714_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cactin. Gene sequence location is X:20295007..20297429.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN20603 HFA20576
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 19D1-19D1   Limits computationally determined from genome sequence between P{EP}amnEP1639&P{EP}amnEP367 and P{EP}CG1702EP1525
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cactin for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cactin-RA FBtr0077305  NM_078698   2423   762
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cactin-PA   FBpp0076997   91.3   762   8.78     NP_523422   AAF50904
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cactin, domain (IPR018816) Cactin protein, cactus-binding domain, C-terminal (IPR019134)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF50904   AF245116 AAF66981   AI107485   AI295469   AI456333   AI511762   AI515471   AI517135   AI518412   AI531045   AI541880   AY121670 AAM51997   BI172391   BI366366   CO268640   CO287105   CO288483   CO312039   CO313586   CO341901   CO345141   EC070852   EC202439   EC207502   EC228564   EC237236   EC240833   EC255205   EC256471   EL876723   EL876724   EV590502
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MRC3 Q9NBV5 Q9VR99
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031114    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031114 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031114 expression level Developmental Stage   Expression Level embryo 00-02hr    2824 embryo 02-04hr    4025 embryo 04-06hr    2554 embryo 06-08hr    2224 embryo 08-10hr    1923 embryo 10-12hr    1403 embryo 12-14hr    1166 embryo 14-16hr    1491 embryo 16-18hr    1182 embryo 18-20hr    758 embryo 20-22hr    1719 embryo 22-24hr    1366 larva L1    751 larva L2    637 larva L3 12hr old    500 larva L3 puffstage 1-2    493 larva L3 puffstage 3-6    690 larva L3 puffstage 7-9    809 white prepupae new    800 white prepupae 12hr    1104 white prepupae 24hr    1069 pupae 2d postWPP    716 pupae 3d postWPP    459 pupae 4d postWPP    392 adult male 01day    452 adult male 05day    548 adult male 30day    657 adult female 01day    954 adult female 05day    1347 adult female 30day    1490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2824) embryo 02-04hr  (4025) embryo 04-06hr  (2554) embryo 06-08hr  (2224) embryo 08-10hr  (1923) embryo 10-12hr  (1403) embryo 12-14hr  (1166) embryo 14-16hr  (1491) embryo 16-18hr  (1182) embryo 18-20hr  (758) embryo 20-22hr  (1719) embryo 22-24hr  (1366) larva L1  (751) larva L2  (637) larva L3 12hr old  (500) larva L3 puffstage 1-2  (493) larva L3 puffstage 3-6  (690) larva L3 puffstage 7-9  (809) white prepupae new  (800) white prepupae 12hr  (1104) white prepupae 24hr  (1069) pupae 2d postWPP  (716) pupae 3d postWPP  (459) pupae 4d postWPP  (392) adult male 01day  (452) adult male 05day  (548) adult male 30day  (657) adult female 01day  (954) adult female 05day  (1347) adult female 30day  (1490) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2824) embryo 02-04hr  (4025) embryo 04-06hr  (2554) embryo 06-08hr  (2224) embryo 08-10hr  (1923) embryo 10-12hr  1403 embryo 12-14hr    1166 embryo 14-16hr  1491 embryo 16-18hr    1182 embryo 18-20hr    758 embryo 20-22hr  (1719) embryo 22-24hr    1366 larva L1    751 larva L2    637 larva L3 12hr old    500 larva L3 puffstage 1-2    493 larva L3 puffstage 3-6    690 larva L3 puffstage 7-9    809 white prepupae new    800 white prepupae 12hr    1104 white prepupae 24hr    1069 pupae 2d postWPP    716 pupae 3d postWPP    459 pupae 4d postWPP    392 adult male 01day    452 adult male 05day    548 adult male 30day    657 adult female 01day    954 adult female 05day    1347 adult female 30day  1490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2824 embryo 02-04hr    4025 embryo 04-06hr    2554 embryo 06-08hr    2224 embryo 08-10hr    1923 embryo 10-12hr    1403 embryo 12-14hr    1166 embryo 14-16hr    1491 embryo 16-18hr    1182 embryo 18-20hr    758 embryo 20-22hr    1719 embryo 22-24hr    1366 larva L1    751 larva L2    637 larva L3 12hr old    500 larva L3 puffstage 1-2    493 larva L3 puffstage 3-6    690 larva L3 puffstage 7-9    809 white prepupae new    800 white prepupae 12hr    1104 white prepupae 24hr    1069 pupae 2d postWPP    716 pupae 3d postWPP    459 pupae 4d postWPP    392 adult male 01day    452 adult male 05day    548 adult male 30day    657 adult female 01day    954 adult female 05day    1347 adult female 30day    1490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2824 embryo 02-04hr    4025 embryo 04-06hr    2554 embryo 06-08hr    2224 embryo 08-10hr    1923 embryo 10-12hr    1403 embryo 12-14hr    1166 embryo 14-16hr    1491 embryo 16-18hr    1182 embryo 18-20hr    758 embryo 20-22hr    1719 embryo 22-24hr    1366 larva L1    751 larva L2    637 larva L3 12hr old    500 larva L3 puffstage 1-2    493 larva L3 puffstage 3-6    690 larva L3 puffstage 7-9    809 white prepupae new    800 white prepupae 12hr    1104 white prepupae 24hr    1069 pupae 2d postWPP    716 pupae 3d postWPP    459 pupae 4d postWPP    392 adult male 01day    452 adult male 05day    548 adult male 30day    657 adult female 01day    954 adult female 05day    1347 adult female 30day    1490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031114 expression level Developmental Stage   Expression Level embryo 00-02hr    2824 embryo 02-04hr    4025 embryo 04-06hr    2554 embryo 06-08hr    2224 embryo 08-10hr    1923 embryo 10-12hr    1403 embryo 12-14hr    1166 embryo 14-16hr    1491 embryo 16-18hr    1182 embryo 18-20hr    758 embryo 20-22hr    1719 embryo 22-24hr    1366 larva L1    751 larva L2    637 larva L3 12hr old    500 larva L3 puffstage 1-2    493 larva L3 puffstage 3-6    690 larva L3 puffstage 7-9    809 white prepupae new    800 white prepupae 12hr    1104 white prepupae 24hr    1069 pupae 2d postWPP    716 pupae 3d postWPP    459 pupae 4d postWPP    392 adult male 01day    452 adult male 05day    548 adult male 30day    657 adult female 01day    954 adult female 05day    1347 adult female 30day    1490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2824) embryo 02-04hr  (4025) embryo 04-06hr  (2554) embryo 06-08hr  (2224) embryo 08-10hr  (1923) embryo 10-12hr  (1403) embryo 12-14hr  (1166) embryo 14-16hr  (1491) embryo 16-18hr  (1182) embryo 18-20hr  (758) embryo 20-22hr  (1719) embryo 22-24hr  (1366) larva L1  (751) larva L2  (637) larva L3 12hr old  (500) larva L3 puffstage 1-2  (493) larva L3 puffstage 3-6  (690) larva L3 puffstage 7-9  (809) white prepupae new  (800) white prepupae 12hr  (1104) white prepupae 24hr  (1069) pupae 2d postWPP  (716) pupae 3d postWPP  (459) pupae 4d postWPP  (392) adult male 01day  (452) adult male 05day  (548) adult male 30day  (657) adult female 01day  (954) adult female 05day  (1347) adult female 30day  (1490) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2824) embryo 02-04hr  (4025) embryo 04-06hr  (2554) embryo 06-08hr  2224 embryo 08-10hr  1923 embryo 10-12hr  1403 embryo 12-14hr    1166 embryo 14-16hr  1491 embryo 16-18hr    1182 embryo 18-20hr    758 embryo 20-22hr  1719 embryo 22-24hr    1366 larva L1    751 larva L2    637 larva L3 12hr old    500 larva L3 puffstage 1-2    493 larva L3 puffstage 3-6    690 larva L3 puffstage 7-9    809 white prepupae new    800 white prepupae 12hr    1104 white prepupae 24hr    1069 pupae 2d postWPP    716 pupae 3d postWPP    459 pupae 4d postWPP    392 adult male 01day    452 adult male 05day    548 adult male 30day    657 adult female 01day    954 adult female 05day    1347 adult female 30day  1490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2824 embryo 02-04hr    4025 embryo 04-06hr    2554 embryo 06-08hr    2224 embryo 08-10hr    1923 embryo 10-12hr    1403 embryo 12-14hr    1166 embryo 14-16hr    1491 embryo 16-18hr    1182 embryo 18-20hr    758 embryo 20-22hr    1719 embryo 22-24hr    1366 larva L1    751 larva L2    637 larva L3 12hr old    500 larva L3 puffstage 1-2    493 larva L3 puffstage 3-6    690 larva L3 puffstage 7-9    809 white prepupae new    800 white prepupae 12hr    1104 white prepupae 24hr    1069 pupae 2d postWPP    716 pupae 3d postWPP    459 pupae 4d postWPP    392 adult male 01day    452 adult male 05day    548 adult male 30day    657 adult female 01day    954 adult female 05day    1347 adult female 30day    1490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2824 embryo 02-04hr    4025 embryo 04-06hr    2554 embryo 06-08hr    2224 embryo 08-10hr    1923 embryo 10-12hr    1403 embryo 12-14hr    1166 embryo 14-16hr    1491 embryo 16-18hr    1182 embryo 18-20hr    758 embryo 20-22hr    1719 embryo 22-24hr    1366 larva L1    751 larva L2    637 larva L3 12hr old    500 larva L3 puffstage 1-2    493 larva L3 puffstage 3-6    690 larva L3 puffstage 7-9    809 white prepupae new    800 white prepupae 12hr    1104 white prepupae 24hr    1069 pupae 2d postWPP    716 pupae 3d postWPP    459 pupae 4d postWPP    392 adult male 01day    452 adult male 05day    548 adult male 30day    657 adult female 01day    954 adult female 05day    1347 adult female 30day    1490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031114    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031114 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031114 expression level Tissue   Expression Level Larval Central Nervous System    164.425 Larval Midgut    89.6 Larval Hindgut    102.4 Larval Malpighian Tubules    199.3 Larval Fat Body    80.9 Larval Salivary Gland    116.4 Larval Trachea    96.725 Larval Carcass    89.7 Adult Head    91.4 Adult Eye    75.65 Adult Brain    135 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    111.9 Adult Midgut    123 Adult Hindgut    119.5 Adult Malpighian Tubules    192.9 Adult Fat Body    57.8 Adult Salivary Gland    127.7 Adult Heart    44.925 Adult VirginFemale Spermatheca    96.7 Adult InseminatedFemale Spermatheca    86.7 Adult Ovary    205.7 Adult Testis    36.7 Adult Male Accessory Gland    82.7 Adult Carcass    81.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    164.425 Larval Midgut    89.6 Larval Hindgut    102.4 Larval Malpighian Tubules    199.3 Larval Fat Body    80.9 Larval Salivary Gland    116.4 Larval Trachea    96.725 Larval Carcass    89.7 Adult Head    91.4 Adult Eye    75.65 Adult Brain    135 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    111.9 Adult Midgut    123 Adult Hindgut    119.5 Adult Malpighian Tubules    192.9 Adult Fat Body    57.8 Adult Salivary Gland    127.7 Adult Heart    44.925 Adult VirginFemale Spermatheca    96.7 Adult InseminatedFemale Spermatheca    86.7 Adult Ovary    205.7 Adult Testis    36.7 Adult Male Accessory Gland    82.7 Adult Carcass    81.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    164.425 Larval Midgut    89.6 Larval Hindgut    102.4 Larval Malpighian Tubules    199.3 Larval Fat Body    80.9 Larval Salivary Gland    116.4 Larval Trachea    96.725 Larval Carcass    89.7 Adult Head    91.4 Adult Eye    75.65 Adult Brain    135 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    111.9 Adult Midgut    123 Adult Hindgut    119.5 Adult Malpighian Tubules    192.9 Adult Fat Body    57.8 Adult Salivary Gland    127.7 Adult Heart    44.925 Adult VirginFemale Spermatheca    96.7 Adult InseminatedFemale Spermatheca    86.7 Adult Ovary    205.7 Adult Testis    36.7 Adult Male Accessory Gland    82.7 Adult Carcass    81.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    164.425 Larval Midgut    89.6 Larval Hindgut    102.4 Larval Malpighian Tubules    199.3 Larval Fat Body    80.9 Larval Salivary Gland    116.4 Larval Trachea    96.725 Larval Carcass    89.7 Adult Head    91.4 Adult Eye    75.65 Adult Brain    135 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    111.9 Adult Midgut    123 Adult Hindgut    119.5 Adult Malpighian Tubules    192.9 Adult Fat Body    57.8 Adult Salivary Gland    127.7 Adult Heart    44.925 Adult VirginFemale Spermatheca    96.7 Adult InseminatedFemale Spermatheca    86.7 Adult Ovary    205.7 Adult Testis    36.7 Adult Male Accessory Gland    82.7 Adult Carcass    81.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031114 expression level Tissue   Expression Level Larval Central Nervous System    164.425 Larval Midgut    89.6 Larval Hindgut    102.4 Larval Malpighian Tubules    199.3 Larval Fat Body    80.9 Larval Salivary Gland    116.4 Larval Trachea    96.725 Larval Carcass    89.7 Adult Head    91.4 Adult Eye    75.65 Adult Brain    135 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    111.9 Adult Midgut    123 Adult Hindgut    119.5 Adult Malpighian Tubules    192.9 Adult Fat Body    57.8 Adult Salivary Gland    127.7 Adult Heart    44.925 Adult VirginFemale Spermatheca    96.7 Adult InseminatedFemale Spermatheca    86.7 Adult Ovary    205.7 Adult Testis    36.7 Adult Male Accessory Gland    82.7 Adult Carcass    81.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    164.425 Larval Midgut    89.6 Larval Hindgut    102.4 Larval Malpighian Tubules    199.3 Larval Fat Body    80.9 Larval Salivary Gland    116.4 Larval Trachea    96.725 Larval Carcass    89.7 Adult Head    91.4 Adult Eye    75.65 Adult Brain    135 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    111.9 Adult Midgut    123 Adult Hindgut    119.5 Adult Malpighian Tubules    192.9 Adult Fat Body    57.8 Adult Salivary Gland    127.7 Adult Heart    44.925 Adult VirginFemale Spermatheca    96.7 Adult InseminatedFemale Spermatheca    86.7 Adult Ovary    205.7 Adult Testis    36.7 Adult Male Accessory Gland    82.7 Adult Carcass    81.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    164.425 Larval Midgut    89.6 Larval Hindgut    102.4 Larval Malpighian Tubules    199.3 Larval Fat Body    80.9 Larval Salivary Gland    116.4 Larval Trachea    96.725 Larval Carcass    89.7 Adult Head    91.4 Adult Eye    75.65 Adult Brain    135 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    111.9 Adult Midgut    123 Adult Hindgut    119.5 Adult Malpighian Tubules    192.9 Adult Fat Body    57.8 Adult Salivary Gland    127.7 Adult Heart    44.925 Adult VirginFemale Spermatheca    96.7 Adult InseminatedFemale Spermatheca    86.7 Adult Ovary    205.7 Adult Testis    36.7 Adult Male Accessory Gland    82.7 Adult Carcass    81.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    164.425 Larval Midgut    89.6 Larval Hindgut    102.4 Larval Malpighian Tubules    199.3 Larval Fat Body    80.9 Larval Salivary Gland    116.4 Larval Trachea    96.725 Larval Carcass    89.7 Adult Head    91.4 Adult Eye    75.65 Adult Brain    135 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    111.9 Adult Midgut    123 Adult Hindgut    119.5 Adult Malpighian Tubules    192.9 Adult Fat Body    57.8 Adult Salivary Gland    127.7 Adult Heart    44.925 Adult VirginFemale Spermatheca    96.7 Adult InseminatedFemale Spermatheca    86.7 Adult Ovary    205.7 Adult Testis    36.7 Adult Male Accessory Gland    82.7 Adult Carcass    81.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    91.4   NA  Eye    75.65   NA  Brain    135   164.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    111.8   NA  Crop    111.9   89.6  Midgut    123   102.4  Hindgut    119.5   199.3  Malpighian Tubules    192.9   80.9  Fat Body    57.8   116.4  Salivary Gland    127.7   NA  Heart    44.925   96.725  Trachea    NA   NA  VirginFemale Spermatheca    96.7   NA  InseminatedFemale Spermatheca    86.7   NA  Ovary    205.7   NA  Testis    36.7   NA  Male Accessory Gland    82.7   89.7  Carcass    81.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031114 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1676-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 cactinGD9200 lethal | pupal stage, with Scer\GAL4pnr-MD237 cactinGD9200 viable, with Scer\GAL4arm.PS cactinScer\UAS.cLa Sterility Allele fertile, with Scer\GAL4arm.PS cactinScer\UAS.cLa Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 cactinGD9200 Phenotype manifest in Allele ganglion mother cell | larval stage, with Scer\GAL41407 cactinGD9200
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of cactin Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cactin Class Mutagen Stocks Known lesion cactinGD9200 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes cactinKK100507 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cactinScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6254 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9200} NA P{KK100507} NA P{UAS-cactin.L} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
dorsal/ventral axis specification inferred from genetic interaction with cact (Lin et al., 2000) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
defense response non-traceable author statement (Lemaitre, 2000.12.20) nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071013 (Herold et al., 2009) signal transduction non-traceable author statement (Lemaitre, 2000.12.20)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cactin allele Gene References cactinScer\UAS.cLa cact (Lin et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59332 DroID - A comprehensive database of gene and protein interactions. • FBgn0031114 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33043
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19092 Dere\GG19290 Dgri\GH17778 Dmoj\GI15124 Dper\GL15935 Dpse\GA25716 Dsec\GM23033 Dvir\GJ18982 Dwil\GK25491 Dyak\GE17882
Curated drosophilid orthologs	Dpse\GA14132
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013167-PA Aedes aegypti (mosquito) AGAP006542-PA Anopheles gambiae (mosquito) XP_624972.2 Apis mellifera (honey bee) XP_001952287.1 Acyrthosiphon pisum (pea aphid) At1g03910.1 Arabidopsis thaliana (wall cress) 87661 Batrachochytrium dendrobatidis (chytrid fungus) 121714 Branchiostoma floridae (lancelet) XP_001891602.1 Brugia malayi (roundworm nematode) ENSBTAP00000013697 Bos taurus (bovine) CBP26583 Caenorhabditis briggsae (nematode) CE20137 Caenorhabditis elegans (worm) ENSCAFP00000028335 Canis familiaris (dog) Chro.50213 Cryptosporidium hominis (obligate parasite) ENSCINP00000009819 Ciona intestinalis (sea squirt) cn01192 Cryptococcus neoformans (yeast-like fungus) cgd5_1690 Cryptosporidium parvum (protozoan parasite) CPIJ002979 Culex pipens (mosquito) ENSCPOP00000003502 Cavia porcellus (guinea pig) ENSCSAVP00000005402 Ciona savignyi (sedentary tunicate) 161063 Capitella spl (polychaete worm) DDB0233566 Dictyostelium discoideum (amoeba) 106396 Daphnia pulex (daphnia) ENSDARP00000078145 Danio rerio (zebra fish) ENSGACP00000020211 Gymnopilus aculeatus (mushroom) 154769 Hypsipyla robusta (cedar shoot borer) ENSP00000221899 Homo sapiens (human) ISCW017768-PA Ixodes scapularis (deer tick) 157867 Lottia gigantea (owl limpet) LmjF28.2330 Leishmania major (virus) 28043 Monocosta brevicollis (choanoflagellate) ENSMODP00000008473 Monodelphis domestica (gray opossum) ENSMUSP00000059533 Mus musculus (house mouse) ENSORLP00000018764 Oryzias latipes (japanese killifish) LOC_Os03g58590.1 Oryza sativa (asian rice) PF08_0124 Plasmodium falciparum (protozoal parasite) PHUM002653-PA Pediculus humanus (human body louse) 196982 Physcomitrella patens (moss) ENSPPYP00000010523 Pongo pygmaeus (orangutan) 81284 Phytophthora ramorum (sudden oak death pathogen) 138205 Phytophthora sojae (root rot pathogen) 589536 Populus trichocarpa (black cottonwood) ENSPTRP00000017458 Pan troglodytes (chimpanzee) PVX_093550 Plasmodium vivax (protozoal parasite) ENSRNOP00000027926 Rattus norvegicus (norway rat) 123104 Sorghum bicolor (sorghum) Smp_038640 Schistosoma mansoni (trematode parasite) SPBC2F12.12c Schizosaccharomyces pombe (fission yeast) XP_001187330.1 Strongylocentrotus purpuratus (purple sea urchin) 52481 Trichoplax adhaerens (metazoa) XP_975642.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018395 Tetraodon nigroviridis (green spotted pufferfish) 20662 Thalassiosira pseudonana (marine diatom) ENSTRUP00000016569 Takifugu rubripes (pufferfish Takifugu) 3712.m00129 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000047821 Xenopus tropicalis (frog) YALI0B09889g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13363 NV50233 LH24562 ISCW017768 FBgn0235320 FBgn0227450 FBgn0206128 FBgn0177901 JGI_V11_106396 FBgn0247093 FBgn0153539 FBgn0137874 FBgn0125248 FBgn0111494 FBgn0096103 CPIJ002979 ACYPI006968 GB13677 AGAP006542 AAEL013167 PHUM370700 GLEAN_08782
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v106979 P{KK100507}VIE-260B v32718 w1118; P{GD9200}v32718 v32719 w1118; P{GD9200}v32719
Genomic Clones ( 2 )
	BACR25I22 BACR30J04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 28 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE14858
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05186 GH27777 LD36269 LD37911 LD43273 LD47321 LP09118 RE51885 SD01916 SD07835
Other clones	104187 107664 214217.64 214321.60 CK01.27D.H5 CK01.82B.F3 CK01.108B.C9 CK01.111C.H3 Dmel_neb_014541_0371_0960 EK064922 EK068609 EK092211 EK227741 EK233510 EP13360 EP21423 IP06650
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031114 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33043
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: cactin CG1676 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of cactin CG1676 was sequence comparison (date:000504). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078698 RefSeq (Proteins) • NP_523422 DDBJ / EMBL / GenBank • AAF50904 AAF66981 AAM51997 AF245116 AY121670 BI172391 Entrez Gene - A searchable database of RefSeq genes. • 33043 UniProtKB/TrEMBL • Q8MRC3 Q9NBV5 Q9VR99
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cactin, domain (IPR018816) Cactin protein, cactus-binding domain, C-terminal (IPR019134)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59332 DroID - A comprehensive database of gene and protein interactions. • FBgn0031114 DRSC - Results from RNAi screens. • FBgn0031114 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031114 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1676-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031114 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33043 InParanoid A subset of ortholog calls from InParanoid. • AAEL013167-PA Aedes aegypti (mosquito) AGAP006542-PA Anopheles gambiae (mosquito) XP_624972.2 Apis mellifera (honey bee) XP_001952287.1 Acyrthosiphon pisum (pea aphid) At1g03910.1 Arabidopsis thaliana (wall cress) 87661 Batrachochytrium dendrobatidis (chytrid fungus) 121714 Branchiostoma floridae (lancelet) XP_001891602.1 Brugia malayi (roundworm nematode) ENSBTAP00000013697 Bos taurus (bovine) CBP26583 Caenorhabditis briggsae (nematode) CE20137 Caenorhabditis elegans (worm) ENSCAFP00000028335 Canis familiaris (dog) Chro.50213 Cryptosporidium hominis (obligate parasite) ENSCINP00000009819 Ciona intestinalis (sea squirt) cn01192 Cryptococcus neoformans (yeast-like fungus) cgd5_1690 Cryptosporidium parvum (protozoan parasite) CPIJ002979 Culex pipens (mosquito) ENSCPOP00000003502 Cavia porcellus (guinea pig) ENSCSAVP00000005402 Ciona savignyi (sedentary tunicate) 161063 Capitella spl (polychaete worm) DDB0233566 Dictyostelium discoideum (amoeba) 106396 Daphnia pulex (daphnia) ENSDARP00000078145 Danio rerio (zebra fish) ENSGACP00000020211 Gymnopilus aculeatus (mushroom) 154769 Hypsipyla robusta (cedar shoot borer) ENSP00000221899 Homo sapiens (human) ISCW017768-PA Ixodes scapularis (deer tick) 157867 Lottia gigantea (owl limpet) LmjF28.2330 Leishmania major (virus) 28043 Monocosta brevicollis (choanoflagellate) ENSMODP00000008473 Monodelphis domestica (gray opossum) ENSMUSP00000059533 Mus musculus (house mouse) ENSORLP00000018764 Oryzias latipes (japanese killifish) LOC_Os03g58590.1 Oryza sativa (asian rice) PF08_0124 Plasmodium falciparum (protozoal parasite) PHUM002653-PA Pediculus humanus (human body louse) 196982 Physcomitrella patens (moss) ENSPPYP00000010523 Pongo pygmaeus (orangutan) 81284 Phytophthora ramorum (sudden oak death pathogen) 138205 Phytophthora sojae (root rot pathogen) 589536 Populus trichocarpa (black cottonwood) ENSPTRP00000017458 Pan troglodytes (chimpanzee) PVX_093550 Plasmodium vivax (protozoal parasite) ENSRNOP00000027926 Rattus norvegicus (norway rat) 123104 Sorghum bicolor (sorghum) Smp_038640 Schistosoma mansoni (trematode parasite) SPBC2F12.12c Schizosaccharomyces pombe (fission yeast) XP_001187330.1 Strongylocentrotus purpuratus (purple sea urchin) 52481 Trichoplax adhaerens (metazoa) XP_975642.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018395 Tetraodon nigroviridis (green spotted pufferfish) 20662 Thalassiosira pseudonana (marine diatom) ENSTRUP00000016569 Takifugu rubripes (pufferfish Takifugu) 3712.m00129 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000047821 Xenopus tropicalis (frog) YALI0B09889g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33043 modMine - Data generated by the modENCODE project. • FBgn0031114 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13363 NV50233 LH24562 ISCW017768 FBgn0235320 FBgn0227450 FBgn0206128 FBgn0177901 JGI_V11_106396 FBgn0247093 FBgn0153539 FBgn0137874 FBgn0125248 FBgn0111494 FBgn0096103 CPIJ002979 ACYPI006968 GB13677 AGAP006542 AAEL013167 PHUM370700 GLEAN_08782
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	cactin (Herold et al., 2009, Chen et al., 2008) CG1676 (Andersen and Tapon, 2008, Keleman et al., 2009.8.5, Herold et al., 2009, Chen et al., 2008)
Name Synonym	cactin (Turner et al., 2008, Lin, 2000.3.14)
Secondary FlyBase IDs
References ( 16 )
Research paper	Herold et al., 2009, Mol. Cell. Biol. 29(1): 281--301 Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. [FBrf0207172] Andersen and Tapon, 2008, J. Biol. Chem. 283(45): 31256--31267 Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. [FBrf0207382] Chen et al., 2008, Genome Res. 18(1): 123--136 Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. [FBrf0202125] Turner et al., 2008, Genetics 179(1): 455--473 Genomic analysis of adaptive differentiation in Drosophila melanogaster. [FBrf0204873] Lin et al., 2000, Mech. Dev. 94(1-2): 57--65 Cactin, a conserved protein that interacts with the Drosophila IkappaB protein Cactus and modulates its function. [FBrf0128552]
Supplementary material	Neumüller et al., 2011, Cell Stem Cell 8(5): Supplemental Table S1. [FBrf0214431] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Lemaitre, 2000.12.20, Drosophila immunity genes. Drosophila immunity genes. [FBrf0133282]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
DNA/RNA sequence record	Lin, 2000.3.14, GenBank/EMBL/DDBJ: AF245116 Drosophila melanogaster cactin mRNA, complete cds. [FBrf0127944]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]