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Gene Dmel\CG14619

General Information
Symbol	Dmel\CG14619	Species	D. melanogaster
Name		Annotation symbol	CG14619
Feature type	protein_coding_gene	FlyBase ID	FBgn0031187
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	20C1-20C1	Sequence location	X:21,857,641..21,870,311 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG14619 (FBgn0031187). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: ubiquitin-specific protease activity. It is reported to be involved in the biological process: protein deubiquitination. 6 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2; Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval Malpighian tubules, adult heart, larval fat body, adult salivary gland, larval trachea, adult ovary, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627278_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of CG14619. Gene sequence location is X:21857641..21870311.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN28078 HFA20633 HFA20590 HFA20632
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 20C1-20C1
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG14619 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG14619-RA FBtr0077348  NM_134618   3434   856 CG14619-RB FBtr0077350  NM_167778   1420   337 CG14619-RC FBtr0077349  NM_167777   4678   938 CG14619-RD FBtr0077347  NM_167775   3247   856 CG14619-RE FBtr0077346  NM_167776   3192   856 CG14619-RF FBtr0309238     4303   938 CG14619-RG FBtr0309239     5176   938
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG14619-PA   FBpp0077040   92.0   856   9.37     NP_608462   AAF50952 CG14619-PB   FBpp0077042   38.6   337   8.08     NP_728456   AAN09567 CG14619-PC   FBpp0077041   101.7   938   9.91     NP_728455   AAN09566 CG14619-PD   FBpp0077039   92.0   856   9.37     NP_728453   AAN09564 CG14619-PE   FBpp0077038   92.0   856   9.37     NP_728454   AAN09565 CG14619-PF   FBpp0301177   101.7   938   9.91       CG14619-PG   FBpp0301178   101.7   938   9.91
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (IPR001394) Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site (IPR018200)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567901   AA694775   AA696435   AE014298 AAF50952   AE014298 AAN09564   AE014298 AAN09565   AE014298 AAN09566   AE014298 AAN09567   AI405514   AI511725   AI515171   AI532692   AW944353   AY069803 AAL39948   AY232239   BF490887   BF491449   BF491903   BF492241   BF493353   BF497702   BF502213   BG633699   BG637654   BG639675   BI214113   BI232918   BI240180   BI242603   BI570794   BI579037   BI585497   BI624805   BT003648 AAO39652   BT088981   BT100212   CA807470   CK132129   CK662518   CO186742   CO187178   CO188255   CO271810   CO280300   CO295925   CO299997   CO310771   CO312788   CO321396   CO326014   CO333643   CO333717   CO333826   CO333892   CO341424   CZ487924   EC065063   EC076094   EC084798   EC089782   EC195024   EC217740   EC228375   EC234882   EC243512   EC251275   EC251306   EC255961   EC263498   EV587090   EV587693   EV588332   EV588616   EV588637   EV589350
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IQ26 Q8IQ27 Q9VR54
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031187    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031187 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031187 expression level Developmental Stage   Expression Level embryo 00-02hr    1460 embryo 02-04hr    1630 embryo 04-06hr    1592 embryo 06-08hr    1509 embryo 08-10hr    1709 embryo 10-12hr    1414 embryo 12-14hr    1614 embryo 14-16hr    2201 embryo 16-18hr    2100 embryo 18-20hr    2125 embryo 20-22hr    1830 embryo 22-24hr    1694 larva L1    1764 larva L2    1327 larva L3 12hr old    1288 larva L3 puffstage 1-2    702 larva L3 puffstage 3-6    1298 larva L3 puffstage 7-9    1233 white prepupae new    1016 white prepupae 12hr    1185 white prepupae 24hr    1383 pupae 2d postWPP    1542 pupae 3d postWPP    2609 pupae 4d postWPP    4436 adult male 01day    2371 adult male 05day    2403 adult male 30day    2216 adult female 01day    1775 adult female 05day    1435 adult female 30day    1370 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1460) embryo 02-04hr  (1630) embryo 04-06hr  (1592) embryo 06-08hr  (1509) embryo 08-10hr  (1709) embryo 10-12hr  (1414) embryo 12-14hr  (1614) embryo 14-16hr  (2201) embryo 16-18hr  (2100) embryo 18-20hr  (2125) embryo 20-22hr  (1830) embryo 22-24hr  (1694) larva L1  (1764) larva L2  (1327) larva L3 12hr old  (1288) larva L3 puffstage 1-2  (702) larva L3 puffstage 3-6  (1298) larva L3 puffstage 7-9  (1233) white prepupae new  (1016) white prepupae 12hr  (1185) white prepupae 24hr  (1383) pupae 2d postWPP  (1542) pupae 3d postWPP  (2609) pupae 4d postWPP  (4436) adult male 01day  (2371) adult male 05day  (2403) adult male 30day  (2216) adult female 01day  (1775) adult female 05day  (1435) adult female 30day  (1370) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1460 embryo 02-04hr  (1630) embryo 04-06hr  (1592) embryo 06-08hr  1509 embryo 08-10hr  (1709) embryo 10-12hr  1414 embryo 12-14hr  (1614) embryo 14-16hr  (2201) embryo 16-18hr  (2100) embryo 18-20hr  (2125) embryo 20-22hr  (1830) embryo 22-24hr  (1694) larva L1  (1764) larva L2    1327 larva L3 12hr old    1288 larva L3 puffstage 1-2    702 larva L3 puffstage 3-6    1298 larva L3 puffstage 7-9    1233 white prepupae new    1016 white prepupae 12hr    1185 white prepupae 24hr    1383 pupae 2d postWPP  (1542) pupae 3d postWPP  (2609) pupae 4d postWPP  (4436) adult male 01day  (2371) adult male 05day  (2403) adult male 30day  (2216) adult female 01day  (1775) adult female 05day  1435 adult female 30day    1370 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1460 embryo 02-04hr    1630 embryo 04-06hr    1592 embryo 06-08hr    1509 embryo 08-10hr    1709 embryo 10-12hr    1414 embryo 12-14hr    1614 embryo 14-16hr    2201 embryo 16-18hr    2100 embryo 18-20hr    2125 embryo 20-22hr    1830 embryo 22-24hr    1694 larva L1    1764 larva L2    1327 larva L3 12hr old    1288 larva L3 puffstage 1-2    702 larva L3 puffstage 3-6    1298 larva L3 puffstage 7-9    1233 white prepupae new    1016 white prepupae 12hr    1185 white prepupae 24hr    1383 pupae 2d postWPP    1542 pupae 3d postWPP    2609 pupae 4d postWPP    4436 adult male 01day    2371 adult male 05day    2403 adult male 30day    2216 adult female 01day    1775 adult female 05day    1435 adult female 30day    1370 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1460 embryo 02-04hr    1630 embryo 04-06hr    1592 embryo 06-08hr    1509 embryo 08-10hr    1709 embryo 10-12hr    1414 embryo 12-14hr    1614 embryo 14-16hr    2201 embryo 16-18hr    2100 embryo 18-20hr    2125 embryo 20-22hr    1830 embryo 22-24hr    1694 larva L1    1764 larva L2    1327 larva L3 12hr old    1288 larva L3 puffstage 1-2    702 larva L3 puffstage 3-6    1298 larva L3 puffstage 7-9    1233 white prepupae new    1016 white prepupae 12hr    1185 white prepupae 24hr    1383 pupae 2d postWPP    1542 pupae 3d postWPP    2609 pupae 4d postWPP    4436 adult male 01day    2371 adult male 05day    2403 adult male 30day    2216 adult female 01day    1775 adult female 05day    1435 adult female 30day    1370 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031187 expression level Developmental Stage   Expression Level embryo 00-02hr    1460 embryo 02-04hr    1630 embryo 04-06hr    1592 embryo 06-08hr    1509 embryo 08-10hr    1709 embryo 10-12hr    1414 embryo 12-14hr    1614 embryo 14-16hr    2201 embryo 16-18hr    2100 embryo 18-20hr    2125 embryo 20-22hr    1830 embryo 22-24hr    1694 larva L1    1764 larva L2    1327 larva L3 12hr old    1288 larva L3 puffstage 1-2    702 larva L3 puffstage 3-6    1298 larva L3 puffstage 7-9    1233 white prepupae new    1016 white prepupae 12hr    1185 white prepupae 24hr    1383 pupae 2d postWPP    1542 pupae 3d postWPP    2609 pupae 4d postWPP    4436 adult male 01day    2371 adult male 05day    2403 adult male 30day    2216 adult female 01day    1775 adult female 05day    1435 adult female 30day    1370 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1460) embryo 02-04hr  (1630) embryo 04-06hr  (1592) embryo 06-08hr  (1509) embryo 08-10hr  (1709) embryo 10-12hr  (1414) embryo 12-14hr  (1614) embryo 14-16hr  (2201) embryo 16-18hr  (2100) embryo 18-20hr  (2125) embryo 20-22hr  (1830) embryo 22-24hr  (1694) larva L1  (1764) larva L2  (1327) larva L3 12hr old  (1288) larva L3 puffstage 1-2  (702) larva L3 puffstage 3-6  (1298) larva L3 puffstage 7-9  (1233) white prepupae new  (1016) white prepupae 12hr  (1185) white prepupae 24hr  (1383) pupae 2d postWPP  (1542) pupae 3d postWPP  (2609) pupae 4d postWPP  (4436) adult male 01day  (2371) adult male 05day  (2403) adult male 30day  (2216) adult female 01day  (1775) adult female 05day  (1435) adult female 30day  (1370) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1460 embryo 02-04hr  1630 embryo 04-06hr  1592 embryo 06-08hr  1509 embryo 08-10hr  1709 embryo 10-12hr  1414 embryo 12-14hr  1614 embryo 14-16hr  2201 embryo 16-18hr  2100 embryo 18-20hr  2125 embryo 20-22hr  1830 embryo 22-24hr  1694 larva L1  1764 larva L2    1327 larva L3 12hr old    1288 larva L3 puffstage 1-2    702 larva L3 puffstage 3-6    1298 larva L3 puffstage 7-9    1233 white prepupae new    1016 white prepupae 12hr    1185 white prepupae 24hr    1383 pupae 2d postWPP  1542 pupae 3d postWPP  (2609) pupae 4d postWPP  (4436) adult male 01day  2371 adult male 05day  2403 adult male 30day  2216 adult female 01day  1775 adult female 05day  1435 adult female 30day    1370 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1460 embryo 02-04hr    1630 embryo 04-06hr    1592 embryo 06-08hr    1509 embryo 08-10hr    1709 embryo 10-12hr    1414 embryo 12-14hr    1614 embryo 14-16hr    2201 embryo 16-18hr    2100 embryo 18-20hr    2125 embryo 20-22hr    1830 embryo 22-24hr    1694 larva L1    1764 larva L2    1327 larva L3 12hr old    1288 larva L3 puffstage 1-2    702 larva L3 puffstage 3-6    1298 larva L3 puffstage 7-9    1233 white prepupae new    1016 white prepupae 12hr    1185 white prepupae 24hr    1383 pupae 2d postWPP    1542 pupae 3d postWPP    2609 pupae 4d postWPP    4436 adult male 01day    2371 adult male 05day    2403 adult male 30day    2216 adult female 01day    1775 adult female 05day    1435 adult female 30day    1370 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1460 embryo 02-04hr    1630 embryo 04-06hr    1592 embryo 06-08hr    1509 embryo 08-10hr    1709 embryo 10-12hr    1414 embryo 12-14hr    1614 embryo 14-16hr    2201 embryo 16-18hr    2100 embryo 18-20hr    2125 embryo 20-22hr    1830 embryo 22-24hr    1694 larva L1    1764 larva L2    1327 larva L3 12hr old    1288 larva L3 puffstage 1-2    702 larva L3 puffstage 3-6    1298 larva L3 puffstage 7-9    1233 white prepupae new    1016 white prepupae 12hr    1185 white prepupae 24hr    1383 pupae 2d postWPP    1542 pupae 3d postWPP    2609 pupae 4d postWPP    4436 adult male 01day    2371 adult male 05day    2403 adult male 30day    2216 adult female 01day    1775 adult female 05day    1435 adult female 30day    1370 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031187    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031187 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval Malpighian tubules, adult heart, larval fat body, adult salivary gland, larval trachea, adult ovary, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031187 expression level Tissue   Expression Level Larval Central Nervous System    244.425 Larval Midgut    74.2 Larval Hindgut    161.8 Larval Malpighian Tubules    171.9 Larval Fat Body    162.7 Larval Salivary Gland    96.1 Larval Trachea    142.5 Larval Carcass    307.55 Adult Head    237.4 Adult Eye    269.85 Adult Brain    378.1 Adult Thoracic-Abdominal Ganglion    418.9 Adult Crop    267.1 Adult Midgut    68.8 Adult Hindgut    191.7 Adult Malpighian Tubules no informative data Adult Fat Body    89.2 Adult Salivary Gland    163.3 Adult Heart    147.175 Adult VirginFemale Spermatheca    23.3 Adult InseminatedFemale Spermatheca    29.2 Adult Ovary    142.8 Adult Testis    515.3 Adult Male Accessory Gland    86 Adult Carcass    253.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    244.425 Larval Midgut    74.2 Larval Hindgut    161.8 Larval Malpighian Tubules    171.9 Larval Fat Body    162.7 Larval Salivary Gland    96.1 Larval Trachea    142.5 Larval Carcass    307.55 Adult Head    237.4 Adult Eye    269.85 Adult Brain    378.1 Adult Thoracic-Abdominal Ganglion    418.9 Adult Crop    267.1 Adult Midgut    68.8 Adult Hindgut    191.7 Adult Malpighian Tubules no informative data Adult Fat Body    89.2 Adult Salivary Gland    163.3 Adult Heart    147.175 Adult VirginFemale Spermatheca    23.3 Adult InseminatedFemale Spermatheca    29.2 Adult Ovary    142.8 Adult Testis  515.3 Adult Male Accessory Gland    86 Adult Carcass    253.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    244.425 Larval Midgut    74.2 Larval Hindgut    161.8 Larval Malpighian Tubules    171.9 Larval Fat Body    162.7 Larval Salivary Gland    96.1 Larval Trachea    142.5 Larval Carcass    307.55 Adult Head    237.4 Adult Eye    269.85 Adult Brain    378.1 Adult Thoracic-Abdominal Ganglion    418.9 Adult Crop    267.1 Adult Midgut    68.8 Adult Hindgut    191.7 Adult Malpighian Tubules no informative data Adult Fat Body    89.2 Adult Salivary Gland    163.3 Adult Heart    147.175 Adult VirginFemale Spermatheca    23.3 Adult InseminatedFemale Spermatheca    29.2 Adult Ovary    142.8 Adult Testis    515.3 Adult Male Accessory Gland    86 Adult Carcass    253.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    244.425 Larval Midgut    74.2 Larval Hindgut    161.8 Larval Malpighian Tubules    171.9 Larval Fat Body    162.7 Larval Salivary Gland    96.1 Larval Trachea    142.5 Larval Carcass    307.55 Adult Head    237.4 Adult Eye    269.85 Adult Brain    378.1 Adult Thoracic-Abdominal Ganglion    418.9 Adult Crop    267.1 Adult Midgut    68.8 Adult Hindgut    191.7 Adult Malpighian Tubules no informative data Adult Fat Body    89.2 Adult Salivary Gland    163.3 Adult Heart    147.175 Adult VirginFemale Spermatheca    23.3 Adult InseminatedFemale Spermatheca    29.2 Adult Ovary    142.8 Adult Testis    515.3 Adult Male Accessory Gland    86 Adult Carcass    253.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031187 expression level Tissue   Expression Level Larval Central Nervous System    244.425 Larval Midgut    74.2 Larval Hindgut    161.8 Larval Malpighian Tubules    171.9 Larval Fat Body    162.7 Larval Salivary Gland    96.1 Larval Trachea    142.5 Larval Carcass    307.55 Adult Head    237.4 Adult Eye    269.85 Adult Brain    378.1 Adult Thoracic-Abdominal Ganglion    418.9 Adult Crop    267.1 Adult Midgut    68.8 Adult Hindgut    191.7 Adult Malpighian Tubules no informative data Adult Fat Body    89.2 Adult Salivary Gland    163.3 Adult Heart    147.175 Adult VirginFemale Spermatheca    23.3 Adult InseminatedFemale Spermatheca    29.2 Adult Ovary    142.8 Adult Testis    515.3 Adult Male Accessory Gland    86 Adult Carcass    253.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    244.425 Larval Midgut    74.2 Larval Hindgut    161.8 Larval Malpighian Tubules    171.9 Larval Fat Body    162.7 Larval Salivary Gland    96.1 Larval Trachea    142.5 Larval Carcass    307.55 Adult Head    237.4 Adult Eye    269.85 Adult Brain    378.1 Adult Thoracic-Abdominal Ganglion    418.9 Adult Crop    267.1 Adult Midgut    68.8 Adult Hindgut    191.7 Adult Malpighian Tubules no informative data Adult Fat Body    89.2 Adult Salivary Gland    163.3 Adult Heart    147.175 Adult VirginFemale Spermatheca    23.3 Adult InseminatedFemale Spermatheca    29.2 Adult Ovary    142.8 Adult Testis  515.3 Adult Male Accessory Gland    86 Adult Carcass    253.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    244.425 Larval Midgut    74.2 Larval Hindgut    161.8 Larval Malpighian Tubules    171.9 Larval Fat Body    162.7 Larval Salivary Gland    96.1 Larval Trachea    142.5 Larval Carcass    307.55 Adult Head    237.4 Adult Eye    269.85 Adult Brain    378.1 Adult Thoracic-Abdominal Ganglion    418.9 Adult Crop    267.1 Adult Midgut    68.8 Adult Hindgut    191.7 Adult Malpighian Tubules no informative data Adult Fat Body    89.2 Adult Salivary Gland    163.3 Adult Heart    147.175 Adult VirginFemale Spermatheca    23.3 Adult InseminatedFemale Spermatheca    29.2 Adult Ovary    142.8 Adult Testis    515.3 Adult Male Accessory Gland    86 Adult Carcass    253.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    244.425 Larval Midgut    74.2 Larval Hindgut    161.8 Larval Malpighian Tubules    171.9 Larval Fat Body    162.7 Larval Salivary Gland    96.1 Larval Trachea    142.5 Larval Carcass    307.55 Adult Head    237.4 Adult Eye    269.85 Adult Brain    378.1 Adult Thoracic-Abdominal Ganglion    418.9 Adult Crop    267.1 Adult Midgut    68.8 Adult Hindgut    191.7 Adult Malpighian Tubules no informative data Adult Fat Body    89.2 Adult Salivary Gland    163.3 Adult Heart    147.175 Adult VirginFemale Spermatheca    23.3 Adult InseminatedFemale Spermatheca    29.2 Adult Ovary    142.8 Adult Testis    515.3 Adult Male Accessory Gland    86 Adult Carcass    253.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    237.4   NA  Eye    269.85   NA  Brain    378.1   244.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    418.9   NA  Crop    267.1   74.2  Midgut    68.8   161.8  Hindgut    191.7   171.9  Malpighian Tubules    no informative data   162.7  Fat Body    89.2   96.1  Salivary Gland    163.3   NA  Heart    147.175   142.5  Trachea    NA   NA  VirginFemale Spermatheca    23.3   NA  InseminatedFemale Spermatheca    29.2   NA  Ovary    142.8   NA  Testis    515.3   NA  Male Accessory Gland    86   307.55  Carcass    253.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031187 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14619-RE;CG18472-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive CG14619PG117 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 CG14619GD5229 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 CG14619GD5229 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 CG14619GD5229
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of CG14619 Class Mutagen Stocks Known lesion CG14619GG01842 P-element activity 1 -- CG14619f05306 piggyBac transposase 0 -- CG14619GG01133 0 -- CG14619PG117 Delta2-3 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG14619 Class Mutagen Stocks Known lesion CG14619GD5229 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG14619KK108078 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6255 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5229} NA P{KK108078} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}CG14619f05306 NA insertion of enhancer trap binary system P{GawB}CG14619PG117 No insertion of mobile activating element P{Mae-UAS.6.11}CG14619GG01133 NA P{Mae-UAS.6.11}CG14619GG01842 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ubiquitin-specific protease activity traceable author statement (MEROPS Project Members, 1996-) ubiquitin thiolesterase activity inferred from electronic annotation with InterPro:IPR001394, InterPro:IPR018200 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
protein deubiquitination traceable author statement (MEROPS Project Members, 1996-) ubiquitin-dependent protein catabolic process inferred from electronic annotation with InterPro:IPR001394, InterPro:IPR018200 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG14619 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59406 DroID - A comprehensive database of gene and protein interactions. • FBgn0031187 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33132
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21001 Dere\GG19743 Dgri\GH17708 Dmoj\GI15450 Dper\GL13296 Dpse\GA13118 Dsec\GM11729 Dsim\GD17542 Dvir\GJ19166 Dwil\GK16418 Dyak\GE17938
Curated drosophilid orthologs	Dpse\GA13118   Dyak\GE17938
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010854-PA Aedes aegypti (mosquito) XP_392493.3 Apis mellifera (honey bee) XP_001944500.1 Acyrthosiphon pisum (pea aphid) At4g24560.1 Arabidopsis thaliana (wall cress) 85066 Batrachochytrium dendrobatidis (chytrid fungus) CBP06360 Caenorhabditis briggsae (nematode) CAGL0J11352g Candida glabrata (haploid yeast) ENSCINP00000023650 Ciona intestinalis (sea squirt) ENSCSAVP00000012973 Ciona savignyi (sedentary tunicate) DEHA2A07942g Debaryomyces Hansenii (yeast) ENSGACP00000006659 Gymnopilus aculeatus (mushroom) 171628 Hypsipyla robusta (cedar shoot borer) 10860 Monocosta brevicollis (choanoflagellate) ENSMODP00000005820 Monodelphis domestica (gray opossum) XP_001599439.1 Nasonia vitripennis (wasp) ENSORLP00000012433 Oryzias latipes (japanese killifish) LOC_Os08g37350.1 Oryza sativa (asian rice) PHUM000952-PA Pediculus humanus (human body louse) 590014 Populus trichocarpa (black cottonwood) PVX_098675 Plasmodium vivax (protozoal parasite) YDR069C Saccharomyces cerevisiae (budding yeast) XP_967750.1 Tribolium castaneum (red flour beetle) ENSTRUP00000045214 Takifugu rubripes (pufferfish Takifugu) 3704.m00086 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000038347 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16447 NV18618 LH10266 ISCW010054 FBgn0068422 FBgn0218420 FBgn0216582 FBgn0206311 FBgn0189092 FBgn0166672 JGI_V11_307972 FBgn0073156 FBgn0150902 FBgn0138199 FBgn0125178 FBgn0111944 FBgn0098006 CPIJ014293 BGIBMGA011368 ACYPI005602 GB14674 AGAP001052 AAEL010854 PHUM596050 GLEAN_15173
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	22139 y1 w67c23 P{Mae-UAS.6.11}CG14619GG01842
VDRC	v104382 P{KK108078}VIE-260B v37929 w1118; P{GD5229}v37929 v37930 w1118; P{GD5229}v37930/TM3
Genomic Clones ( 1 )
	BACR06L03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 66 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT03982 AT11044 SD04280
Other clones	MIP13335 yak-ad_CG14619
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01684 AT11949 AT17873 AT27517 AT28189 AT28670 AT29144 AT29404 GH25535 GM01518 GM07674 LD43222 LD46883 LP13410 LP22803 RE19824 RE29068 RE36863 RE39986 RE73008 RH05576 RH25089 RH64504
Other clones	40609 60779 99689 105148 173293 214531.48 281965 282588 282860 571390 CK01.25C.H6 CK01.31A.D7 CK01.170C.F7 Dmel_neb_010190_0193_0750 Dmel_neb_011621_0136_1223 Dmel_neb_011674_0085_1821 Dmel_neb_012686_0114_1751 Dmel_neb_014231_0404_2825 Dmel_neb_014279_0194_2937 EK022663 EK026916 EK038753 EK104716 EK153650 EK177205 EK185611 EK212303 EK222458 EK229966 EK307533 EK307763 EK308113 EK308255 EP03056 EP12424 ESG018a.E21_E06 HL01966 SD04239
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031187 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33132
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134618 NM_167775 NM_167776 NM_167777 NM_167778 RefSeq (Proteins) • NP_608462 NP_728453 NP_728454 NP_728455 NP_728456 DDBJ / EMBL / GenBank • AAF50952 AAL39948 AAN09564 AAN09565 AAN09566 AAN09567 AAO39652 AI532692 AW944353 AY069803 BT003648 CZ487924 Entrez Gene - A searchable database of RefSeq genes. • 33132 UniProtKB/TrEMBL • Q8IQ26 Q8IQ27 Q9VR54
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (IPR001394) Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site (IPR018200)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59406 DroID - A comprehensive database of gene and protein interactions. • FBgn0031187 DRSC - Results from RNAi screens. • FBgn0031187 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031187 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14619-RE;CG18472-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031187 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33132 InParanoid A subset of ortholog calls from InParanoid. • AAEL010854-PA Aedes aegypti (mosquito) XP_392493.3 Apis mellifera (honey bee) XP_001944500.1 Acyrthosiphon pisum (pea aphid) At4g24560.1 Arabidopsis thaliana (wall cress) 85066 Batrachochytrium dendrobatidis (chytrid fungus) CBP06360 Caenorhabditis briggsae (nematode) CAGL0J11352g Candida glabrata (haploid yeast) ENSCINP00000023650 Ciona intestinalis (sea squirt) ENSCSAVP00000012973 Ciona savignyi (sedentary tunicate) DEHA2A07942g Debaryomyces Hansenii (yeast) ENSGACP00000006659 Gymnopilus aculeatus (mushroom) 171628 Hypsipyla robusta (cedar shoot borer) 10860 Monocosta brevicollis (choanoflagellate) ENSMODP00000005820 Monodelphis domestica (gray opossum) XP_001599439.1 Nasonia vitripennis (wasp) ENSORLP00000012433 Oryzias latipes (japanese killifish) LOC_Os08g37350.1 Oryza sativa (asian rice) PHUM000952-PA Pediculus humanus (human body louse) 590014 Populus trichocarpa (black cottonwood) PVX_098675 Plasmodium vivax (protozoal parasite) YDR069C Saccharomyces cerevisiae (budding yeast) XP_967750.1 Tribolium castaneum (red flour beetle) ENSTRUP00000045214 Takifugu rubripes (pufferfish Takifugu) 3704.m00086 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000038347 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33132 modMine - Data generated by the modENCODE project. • FBgn0031187 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16447 NV18618 LH10266 ISCW010054 FBgn0068422 FBgn0218420 FBgn0216582 FBgn0206311 FBgn0189092 FBgn0166672 JGI_V11_307972 FBgn0073156 FBgn0150902 FBgn0138199 FBgn0125178 FBgn0111944 FBgn0098006 CPIJ014293 BGIBMGA011368 ACYPI005602 GB14674 AGAP001052 AAEL010854 PHUM596050 GLEAN_15173
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG14619 (Gan et al., 2010, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 19 )
Research paper	Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Bourbon et al., 2002, Mech. Dev. 110(1-2): 71--83 A P-insertion screen identifying novel X-linked essential genes in Drosophila. [FBrf0141645] Chen and Fischer, 2000, Genetics 156(4): 1829--1836 In vivo structure/function analysis of the Drosophila fat facets deubiquitinating enzyme gene. [FBrf0131273]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078] MEROPS Project Members, 1996-, MEROPS. MEROPS. [FBrf0128212]
Stock list	Bloomington Drosophila Stock Center, 19??-, Bloomington Stock List. Bloomington Stock List. [FBrf0141259]
Curated genome annotation	Gong, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126669]