Predicted to enable calcium ion binding activity. Involved in mitochondrion organization. Located in mitochondria-associated endoplasmic reticulum membrane contact site. Is expressed in adult head. Human ortholog(s) of this gene implicated in atrioventricular septal defect and heart septal defect. Orthologous to human CRELD1 (cysteine rich with EGF like domains 1) and CRELD2 (cysteine rich with EGF like domains 2).
The gene Cysteine rich with EGF like domains is referred to in FlyBase by the symbol Dmel\Creld (CG11377, FBgn0031217). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (all unique). Gene sequence location is 2L:102380..104142. Its molecular function is described by: calcium ion binding. It is involved in the biological process described with: mitochondrion organization. 9 alleles are reported. The phenotypes of these alleles manifest in: indirect flight muscle; mitochondrion; adult cardial cell; adult heart. The phenotypic classes of alleles include: abnormal adult walking behavior; partially lethal; short lived; chemical resistant; viable; decreased rate of adult locomotory behavior. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes.
Please see the JBrowse view of Dmel\Creld for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Gene model reviewed during 5.45
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Creld using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Creld in JBrowseThe gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.
Category | Common alleles (# stocks) |
---|---|
Classical and Insertion Alleles | |
Loss of function allele | |
Amorphic allele | |
Fluorescently-tagged allele | |
Transgenic Constructs | |
UAS RNAi | |
UAS wild-type cDNA | |
Untagged genomic rescue | |
Fluorescently-tagged genomic rescue | |
Aberrations | |
Deficiency | |
Duplication |
2-0.5
2-0.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Creld CG11377