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Gene Dmel\CG11377

General Information
Symbol	Dmel\CG11377	Species	D. melanogaster
Name		Annotation symbol	CG11377
Feature type	protein_coding_gene	FlyBase ID	FBgn0031217
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	21B2-21B2	Sequence location	2L:102,382..104,142 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11377 (FBgn0031217). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: calcium ion binding. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like region, conserved site; EGF-like, laminin; Epidermal growth factor-like; Epidermal growth factor-like, type 3; Furin-like repeat; Growth factor, receptor; Protein of unknown function DUF3456. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633661_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11377. Gene sequence location is 2L:102382..104142.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA00308 BKN20661
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21B2-21B2   Limits computationally determined from genome sequence between P{lacW}spenk06805&P{lacW}l(2)k13604k13604 and P{lacW}U2af38k14504
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11377 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11377-RA FBtr0078104  NM_134646   1581   374
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11377-PA   FBpp0077763   41.2   374   5.31     NP_608490   AAF51560
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Epidermal growth factor-like, type 3 (IPR000742) EGF-like, laminin (IPR002049) Furin-like repeat (IPR006212) Growth factor, receptor (IPR009030) EGF-like region, conserved site (IPR013032) EGF-like calcium-binding, conserved site (IPR018097) Protein of unknown function DUF3456 (IPR021852) Epidermal growth factor-like (IPR006210) EGF-like calcium-binding (IPR001881)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51560   AI293891   AY071548 AAL49170   BG635533   BI172937   BI227681   BI370792   BI371522   BI637912   BI639320   CK133915   CO277648   CO278369   CO279832   CO302314   CO326969   EC200333   EC221170   EC255666   GH738882   GH739072   GH739256   GH741202   GH741638   GH745698   GH746866   GH761760   GH762779   GH763844   GH768480   GH779730   GO254385
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VPJ0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031217    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031217 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031217 expression level Developmental Stage   Expression Level embryo 00-02hr    3904 embryo 02-04hr    1006 embryo 04-06hr    2975 embryo 06-08hr    2654 embryo 08-10hr    2729 embryo 10-12hr    2393 embryo 12-14hr    1783 embryo 14-16hr    1892 embryo 16-18hr    1682 embryo 18-20hr    1026 embryo 20-22hr    535 embryo 22-24hr    515 larva L1    1560 larva L2    3200 larva L3 12hr old    1717 larva L3 puffstage 1-2    1107 larva L3 puffstage 3-6    1432 larva L3 puffstage 7-9    1776 white prepupae new    1787 white prepupae 12hr    1576 white prepupae 24hr    1900 pupae 2d postWPP    1394 pupae 3d postWPP    734 pupae 4d postWPP    666 adult male 01day    1459 adult male 05day    1560 adult male 30day    1849 adult female 01day    2403 adult female 05day    3466 adult female 30day    3231 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3904) embryo 02-04hr  (1006) embryo 04-06hr  (2975) embryo 06-08hr  (2654) embryo 08-10hr  (2729) embryo 10-12hr  (2393) embryo 12-14hr  (1783) embryo 14-16hr  (1892) embryo 16-18hr  (1682) embryo 18-20hr  (1026) embryo 20-22hr  (535) embryo 22-24hr  (515) larva L1  (1560) larva L2  (3200) larva L3 12hr old  (1717) larva L3 puffstage 1-2  (1107) larva L3 puffstage 3-6  (1432) larva L3 puffstage 7-9  (1776) white prepupae new  (1787) white prepupae 12hr  (1576) white prepupae 24hr  (1900) pupae 2d postWPP  (1394) pupae 3d postWPP  (734) pupae 4d postWPP  (666) adult male 01day  (1459) adult male 05day  (1560) adult male 30day  (1849) adult female 01day  (2403) adult female 05day  (3466) adult female 30day  (3231) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3904) embryo 02-04hr    1006 embryo 04-06hr  (2975) embryo 06-08hr  (2654) embryo 08-10hr  (2729) embryo 10-12hr  (2393) embryo 12-14hr  (1783) embryo 14-16hr  (1892) embryo 16-18hr  (1682) embryo 18-20hr    1026 embryo 20-22hr    535 embryo 22-24hr    515 larva L1  (1560) larva L2  (3200) larva L3 12hr old  (1717) larva L3 puffstage 1-2    1107 larva L3 puffstage 3-6  1432 larva L3 puffstage 7-9  (1776) white prepupae new  (1787) white prepupae 12hr  (1576) white prepupae 24hr  (1900) pupae 2d postWPP    1394 pupae 3d postWPP    734 pupae 4d postWPP    666 adult male 01day  1459 adult male 05day  (1560) adult male 30day  (1849) adult female 01day  (2403) adult female 05day  (3466) adult female 30day  (3231) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3904 embryo 02-04hr    1006 embryo 04-06hr    2975 embryo 06-08hr    2654 embryo 08-10hr    2729 embryo 10-12hr    2393 embryo 12-14hr    1783 embryo 14-16hr    1892 embryo 16-18hr    1682 embryo 18-20hr    1026 embryo 20-22hr    535 embryo 22-24hr    515 larva L1    1560 larva L2    3200 larva L3 12hr old    1717 larva L3 puffstage 1-2    1107 larva L3 puffstage 3-6    1432 larva L3 puffstage 7-9    1776 white prepupae new    1787 white prepupae 12hr    1576 white prepupae 24hr    1900 pupae 2d postWPP    1394 pupae 3d postWPP    734 pupae 4d postWPP    666 adult male 01day    1459 adult male 05day    1560 adult male 30day    1849 adult female 01day    2403 adult female 05day    3466 adult female 30day    3231 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3904 embryo 02-04hr    1006 embryo 04-06hr    2975 embryo 06-08hr    2654 embryo 08-10hr    2729 embryo 10-12hr    2393 embryo 12-14hr    1783 embryo 14-16hr    1892 embryo 16-18hr    1682 embryo 18-20hr    1026 embryo 20-22hr    535 embryo 22-24hr    515 larva L1    1560 larva L2    3200 larva L3 12hr old    1717 larva L3 puffstage 1-2    1107 larva L3 puffstage 3-6    1432 larva L3 puffstage 7-9    1776 white prepupae new    1787 white prepupae 12hr    1576 white prepupae 24hr    1900 pupae 2d postWPP    1394 pupae 3d postWPP    734 pupae 4d postWPP    666 adult male 01day    1459 adult male 05day    1560 adult male 30day    1849 adult female 01day    2403 adult female 05day    3466 adult female 30day    3231 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031217 expression level Developmental Stage   Expression Level embryo 00-02hr    3904 embryo 02-04hr    1006 embryo 04-06hr    2975 embryo 06-08hr    2654 embryo 08-10hr    2729 embryo 10-12hr    2393 embryo 12-14hr    1783 embryo 14-16hr    1892 embryo 16-18hr    1682 embryo 18-20hr    1026 embryo 20-22hr    535 embryo 22-24hr    515 larva L1    1560 larva L2    3200 larva L3 12hr old    1717 larva L3 puffstage 1-2    1107 larva L3 puffstage 3-6    1432 larva L3 puffstage 7-9    1776 white prepupae new    1787 white prepupae 12hr    1576 white prepupae 24hr    1900 pupae 2d postWPP    1394 pupae 3d postWPP    734 pupae 4d postWPP    666 adult male 01day    1459 adult male 05day    1560 adult male 30day    1849 adult female 01day    2403 adult female 05day    3466 adult female 30day    3231 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3904) embryo 02-04hr  (1006) embryo 04-06hr  (2975) embryo 06-08hr  (2654) embryo 08-10hr  (2729) embryo 10-12hr  (2393) embryo 12-14hr  (1783) embryo 14-16hr  (1892) embryo 16-18hr  (1682) embryo 18-20hr  (1026) embryo 20-22hr  (535) embryo 22-24hr  (515) larva L1  (1560) larva L2  (3200) larva L3 12hr old  (1717) larva L3 puffstage 1-2  (1107) larva L3 puffstage 3-6  (1432) larva L3 puffstage 7-9  (1776) white prepupae new  (1787) white prepupae 12hr  (1576) white prepupae 24hr  (1900) pupae 2d postWPP  (1394) pupae 3d postWPP  (734) pupae 4d postWPP  (666) adult male 01day  (1459) adult male 05day  (1560) adult male 30day  (1849) adult female 01day  (2403) adult female 05day  (3466) adult female 30day  (3231) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3904) embryo 02-04hr    1006 embryo 04-06hr  (2975) embryo 06-08hr  (2654) embryo 08-10hr  (2729) embryo 10-12hr  2393 embryo 12-14hr  1783 embryo 14-16hr  1892 embryo 16-18hr  1682 embryo 18-20hr    1026 embryo 20-22hr    535 embryo 22-24hr    515 larva L1  1560 larva L2  (3200) larva L3 12hr old  1717 larva L3 puffstage 1-2    1107 larva L3 puffstage 3-6  1432 larva L3 puffstage 7-9  1776 white prepupae new  1787 white prepupae 12hr  1576 white prepupae 24hr  1900 pupae 2d postWPP    1394 pupae 3d postWPP    734 pupae 4d postWPP    666 adult male 01day  1459 adult male 05day  1560 adult male 30day  1849 adult female 01day  2403 adult female 05day  (3466) adult female 30day  (3231) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3904 embryo 02-04hr    1006 embryo 04-06hr    2975 embryo 06-08hr    2654 embryo 08-10hr    2729 embryo 10-12hr    2393 embryo 12-14hr    1783 embryo 14-16hr    1892 embryo 16-18hr    1682 embryo 18-20hr    1026 embryo 20-22hr    535 embryo 22-24hr    515 larva L1    1560 larva L2    3200 larva L3 12hr old    1717 larva L3 puffstage 1-2    1107 larva L3 puffstage 3-6    1432 larva L3 puffstage 7-9    1776 white prepupae new    1787 white prepupae 12hr    1576 white prepupae 24hr    1900 pupae 2d postWPP    1394 pupae 3d postWPP    734 pupae 4d postWPP    666 adult male 01day    1459 adult male 05day    1560 adult male 30day    1849 adult female 01day    2403 adult female 05day    3466 adult female 30day    3231 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3904 embryo 02-04hr    1006 embryo 04-06hr    2975 embryo 06-08hr    2654 embryo 08-10hr    2729 embryo 10-12hr    2393 embryo 12-14hr    1783 embryo 14-16hr    1892 embryo 16-18hr    1682 embryo 18-20hr    1026 embryo 20-22hr    535 embryo 22-24hr    515 larva L1    1560 larva L2    3200 larva L3 12hr old    1717 larva L3 puffstage 1-2    1107 larva L3 puffstage 3-6    1432 larva L3 puffstage 7-9    1776 white prepupae new    1787 white prepupae 12hr    1576 white prepupae 24hr    1900 pupae 2d postWPP    1394 pupae 3d postWPP    734 pupae 4d postWPP    666 adult male 01day    1459 adult male 05day    1560 adult male 30day    1849 adult female 01day    2403 adult female 05day    3466 adult female 30day    3231 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031217    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031217 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031217 expression level Tissue   Expression Level Larval Central Nervous System    288.375 Larval Midgut    95.3 Larval Hindgut    70 Larval Malpighian Tubules    40.4 Larval Fat Body    176.3 Larval Salivary Gland    527.6 Larval Trachea    214.525 Larval Carcass    74.675 Adult Head    183.4 Adult Eye    182.7 Adult Brain    250.4 Adult Thoracic-Abdominal Ganglion    275.6 Adult Crop    108.1 Adult Midgut    222.4 Adult Hindgut    97.6 Adult Malpighian Tubules    107.7 Adult Fat Body    310 Adult Salivary Gland    394.7 Adult Heart    396.65 Adult VirginFemale Spermatheca    336.2 Adult InseminatedFemale Spermatheca    423 Adult Ovary    375.5 Adult Testis    48.9 Adult Male Accessory Gland    757.9 Adult Carcass    249.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    288.375 Larval Midgut    95.3 Larval Hindgut    70 Larval Malpighian Tubules    40.4 Larval Fat Body    176.3 Larval Salivary Gland  527.6 Larval Trachea    214.525 Larval Carcass    74.675 Adult Head    183.4 Adult Eye    182.7 Adult Brain    250.4 Adult Thoracic-Abdominal Ganglion    275.6 Adult Crop    108.1 Adult Midgut    222.4 Adult Hindgut    97.6 Adult Malpighian Tubules    107.7 Adult Fat Body    310 Adult Salivary Gland    394.7 Adult Heart    396.65 Adult VirginFemale Spermatheca    336.2 Adult InseminatedFemale Spermatheca    423 Adult Ovary    375.5 Adult Testis    48.9 Adult Male Accessory Gland  (757.9) Adult Carcass    249.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    288.375 Larval Midgut    95.3 Larval Hindgut    70 Larval Malpighian Tubules    40.4 Larval Fat Body    176.3 Larval Salivary Gland    527.6 Larval Trachea    214.525 Larval Carcass    74.675 Adult Head    183.4 Adult Eye    182.7 Adult Brain    250.4 Adult Thoracic-Abdominal Ganglion    275.6 Adult Crop    108.1 Adult Midgut    222.4 Adult Hindgut    97.6 Adult Malpighian Tubules    107.7 Adult Fat Body    310 Adult Salivary Gland    394.7 Adult Heart    396.65 Adult VirginFemale Spermatheca    336.2 Adult InseminatedFemale Spermatheca    423 Adult Ovary    375.5 Adult Testis    48.9 Adult Male Accessory Gland    757.9 Adult Carcass    249.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    288.375 Larval Midgut    95.3 Larval Hindgut    70 Larval Malpighian Tubules    40.4 Larval Fat Body    176.3 Larval Salivary Gland    527.6 Larval Trachea    214.525 Larval Carcass    74.675 Adult Head    183.4 Adult Eye    182.7 Adult Brain    250.4 Adult Thoracic-Abdominal Ganglion    275.6 Adult Crop    108.1 Adult Midgut    222.4 Adult Hindgut    97.6 Adult Malpighian Tubules    107.7 Adult Fat Body    310 Adult Salivary Gland    394.7 Adult Heart    396.65 Adult VirginFemale Spermatheca    336.2 Adult InseminatedFemale Spermatheca    423 Adult Ovary    375.5 Adult Testis    48.9 Adult Male Accessory Gland    757.9 Adult Carcass    249.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031217 expression level Tissue   Expression Level Larval Central Nervous System    288.375 Larval Midgut    95.3 Larval Hindgut    70 Larval Malpighian Tubules    40.4 Larval Fat Body    176.3 Larval Salivary Gland    527.6 Larval Trachea    214.525 Larval Carcass    74.675 Adult Head    183.4 Adult Eye    182.7 Adult Brain    250.4 Adult Thoracic-Abdominal Ganglion    275.6 Adult Crop    108.1 Adult Midgut    222.4 Adult Hindgut    97.6 Adult Malpighian Tubules    107.7 Adult Fat Body    310 Adult Salivary Gland    394.7 Adult Heart    396.65 Adult VirginFemale Spermatheca    336.2 Adult InseminatedFemale Spermatheca    423 Adult Ovary    375.5 Adult Testis    48.9 Adult Male Accessory Gland    757.9 Adult Carcass    249.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    288.375 Larval Midgut    95.3 Larval Hindgut    70 Larval Malpighian Tubules    40.4 Larval Fat Body    176.3 Larval Salivary Gland  527.6 Larval Trachea    214.525 Larval Carcass    74.675 Adult Head    183.4 Adult Eye    182.7 Adult Brain    250.4 Adult Thoracic-Abdominal Ganglion    275.6 Adult Crop    108.1 Adult Midgut    222.4 Adult Hindgut    97.6 Adult Malpighian Tubules    107.7 Adult Fat Body    310 Adult Salivary Gland    394.7 Adult Heart    396.65 Adult VirginFemale Spermatheca    336.2 Adult InseminatedFemale Spermatheca    423 Adult Ovary    375.5 Adult Testis    48.9 Adult Male Accessory Gland  757.9 Adult Carcass    249.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    288.375 Larval Midgut    95.3 Larval Hindgut    70 Larval Malpighian Tubules    40.4 Larval Fat Body    176.3 Larval Salivary Gland    527.6 Larval Trachea    214.525 Larval Carcass    74.675 Adult Head    183.4 Adult Eye    182.7 Adult Brain    250.4 Adult Thoracic-Abdominal Ganglion    275.6 Adult Crop    108.1 Adult Midgut    222.4 Adult Hindgut    97.6 Adult Malpighian Tubules    107.7 Adult Fat Body    310 Adult Salivary Gland    394.7 Adult Heart    396.65 Adult VirginFemale Spermatheca    336.2 Adult InseminatedFemale Spermatheca    423 Adult Ovary    375.5 Adult Testis    48.9 Adult Male Accessory Gland    757.9 Adult Carcass    249.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    288.375 Larval Midgut    95.3 Larval Hindgut    70 Larval Malpighian Tubules    40.4 Larval Fat Body    176.3 Larval Salivary Gland    527.6 Larval Trachea    214.525 Larval Carcass    74.675 Adult Head    183.4 Adult Eye    182.7 Adult Brain    250.4 Adult Thoracic-Abdominal Ganglion    275.6 Adult Crop    108.1 Adult Midgut    222.4 Adult Hindgut    97.6 Adult Malpighian Tubules    107.7 Adult Fat Body    310 Adult Salivary Gland    394.7 Adult Heart    396.65 Adult VirginFemale Spermatheca    336.2 Adult InseminatedFemale Spermatheca    423 Adult Ovary    375.5 Adult Testis    48.9 Adult Male Accessory Gland    757.9 Adult Carcass    249.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    183.4   NA  Eye    182.7   NA  Brain    250.4   288.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    275.6   NA  Crop    108.1   95.3  Midgut    222.4   70  Hindgut    97.6   40.4  Malpighian Tubules    107.7   176.3  Fat Body    310   527.6  Salivary Gland    394.7   NA  Heart    396.65   214.525  Trachea    NA   NA  VirginFemale Spermatheca    336.2   NA  InseminatedFemale Spermatheca    423   NA  Ovary    375.5   NA  Testis    48.9   NA  Male Accessory Gland    757.9   74.675  Carcass    249.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031217 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11377-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG11377 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11377 Class Mutagen Stocks Known lesion CG11377KK100565 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11377GD774 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6001 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD774} NA P{KK100565} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR018097 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11377 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59428 DroID - A comprehensive database of gene and protein interactions. • FBgn0031217 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33166
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14862 Dere\GG24694 Dgri\GH13622 Dmoj\GI11694 Dpse\GA10958 Dsec\GM16714 Dsim\GD23000 Dvir\GJ13058 Dwil\GK24605 Dyak\GE16571
Curated drosophilid orthologs	Dpse\GA10958
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP007968-PA Anopheles gambiae (mosquito) XP_394353.2 Apis mellifera (honey bee) XP_001945868.1 Acyrthosiphon pisum (pea aphid) 174371 Branchiostoma floridae (lancelet) BGIBMGA007648-PA Bombyx mori (silk worm) ENSBTAP00000014377 Bos taurus (bovine) CN15550 Caenorhabditis brenneri (small nematode) CN22756 Caenorhabditis brenneri (small nematode) CBP20995 Caenorhabditis briggsae (nematode) CE05579 Caenorhabditis elegans (worm) ENSCAFP00000001013 Canis familiaris (dog) ENSCINP00000024648 Ciona intestinalis (sea squirt) JA00971 Caenorhabditis japonica (nematode) CPIJ005483 Culex pipens (mosquito) ENSCPOP00000006040 Cavia porcellus (guinea pig) RP02620 Caenorhabditis remanei (nematode) ENSCSAVP00000016445 Ciona savignyi (sedentary tunicate) 152135 Capitella spl (polychaete worm) 188272 Daphnia pulex (daphnia) ENSDARP00000048382 Danio rerio (zebra fish) ENSECAP00000012744 Equus caballus (horse) ENSGACP00000025122 Gymnopilus aculeatus (mushroom) ENSGALP00000013913 Gallus gallus (chicken) 189281 Hypsipyla robusta (cedar shoot borer) ENSP00000295982 Homo sapiens (human) ISCW023134-PA Ixodes scapularis (deer tick) 75888 Lottia gigantea (owl limpet) ENSMODP00000006608 Monodelphis domestica (gray opossum) ENSMMUP00000024042 Macaca mulatta (rhesus monkey) ENSMUSP00000032422 Mus musculus (house mouse) 92522 Nematostella vectensis (starlet anemone) XP_001603904.1 Nasonia vitripennis (wasp) ENSORLP00000014508 Oryzias latipes (japanese killifish) PHUM000309-PA Pediculus humanus (human body louse) PP22752 Pristionchus pacificus (nematode) ENSPPYP00000015285 Pongo pygmaeus (orangutan) ENSPTRP00000054689 Pan troglodytes (chimpanzee) ENSRNOP00000013052 Rattus norvegicus (norway rat) Smp_157070 Schistosoma mansoni (trematode parasite) XP_795729.2 Strongylocentrotus purpuratus (purple sea urchin) 61862 Trichoplax adhaerens (metazoa) XP_971778.1 Tribolium castaneum (red flour beetle) ENSTNIP00000009560 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000003110 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000031785 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10820 NV16663 LH17313 ISCW023134 FBgn0234085 FBgn0226565 FBgn0200291 FBgn0194392 FBgn0171627 JGI_V11_188272 FBgn0071014 FBgn0134453 FBgn0121098 FBgn0116825 FBgn0091889 CPIJ005483 CPIJ000116 BGIBMGA007648 ACYPI002400 GB13112 AGAP007968 AAEL013067 PHUM453010 GLEAN_05174
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v107205 P{KK100565}VIE-260B
Genomic Clones ( 1 )
	BACR09J20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 27 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE58433
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP07145 RE15642 RE24791 RE42721 RE57540 SD12971 SD20064 SD21877
Other clones	EK125708 EK129908 EK136128 EK183862 EP05058 RP01220 RP01542 RP001009021 RP001010782 RP001011468 RP001012261 RP001013642 RP001017669 RP001019570 RP001024941 RP001030955 RP001034067 RP001036550
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031217 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33166
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134646 RefSeq (Proteins) • NP_608490 DDBJ / EMBL / GenBank • AAF51560 AAL49170 AY071548 BI371522 Entrez Gene - A searchable database of RefSeq genes. • 33166 UniProtKB/TrEMBL • Q9VPJ0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Epidermal growth factor-like, type 3 (IPR000742) EGF-like, laminin (IPR002049) Furin-like repeat (IPR006212) Growth factor, receptor (IPR009030) EGF-like region, conserved site (IPR013032) EGF-like calcium-binding, conserved site (IPR018097) Protein of unknown function DUF3456 (IPR021852) Epidermal growth factor-like (IPR006210) EGF-like calcium-binding (IPR001881)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59428 DroID - A comprehensive database of gene and protein interactions. • FBgn0031217 DRSC - Results from RNAi screens. • FBgn0031217 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031217 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11377-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031217 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33166 InParanoid A subset of ortholog calls from InParanoid. • AGAP007968-PA Anopheles gambiae (mosquito) XP_394353.2 Apis mellifera (honey bee) XP_001945868.1 Acyrthosiphon pisum (pea aphid) 174371 Branchiostoma floridae (lancelet) BGIBMGA007648-PA Bombyx mori (silk worm) ENSBTAP00000014377 Bos taurus (bovine) CN15550 Caenorhabditis brenneri (small nematode) CN22756 Caenorhabditis brenneri (small nematode) CBP20995 Caenorhabditis briggsae (nematode) CE05579 Caenorhabditis elegans (worm) ENSCAFP00000001013 Canis familiaris (dog) ENSCINP00000024648 Ciona intestinalis (sea squirt) JA00971 Caenorhabditis japonica (nematode) CPIJ005483 Culex pipens (mosquito) ENSCPOP00000006040 Cavia porcellus (guinea pig) RP02620 Caenorhabditis remanei (nematode) ENSCSAVP00000016445 Ciona savignyi (sedentary tunicate) 152135 Capitella spl (polychaete worm) 188272 Daphnia pulex (daphnia) ENSDARP00000048382 Danio rerio (zebra fish) ENSECAP00000012744 Equus caballus (horse) ENSGACP00000025122 Gymnopilus aculeatus (mushroom) ENSGALP00000013913 Gallus gallus (chicken) 189281 Hypsipyla robusta (cedar shoot borer) ENSP00000295982 Homo sapiens (human) ISCW023134-PA Ixodes scapularis (deer tick) 75888 Lottia gigantea (owl limpet) ENSMODP00000006608 Monodelphis domestica (gray opossum) ENSMMUP00000024042 Macaca mulatta (rhesus monkey) ENSMUSP00000032422 Mus musculus (house mouse) 92522 Nematostella vectensis (starlet anemone) XP_001603904.1 Nasonia vitripennis (wasp) ENSORLP00000014508 Oryzias latipes (japanese killifish) PHUM000309-PA Pediculus humanus (human body louse) PP22752 Pristionchus pacificus (nematode) ENSPPYP00000015285 Pongo pygmaeus (orangutan) ENSPTRP00000054689 Pan troglodytes (chimpanzee) ENSRNOP00000013052 Rattus norvegicus (norway rat) Smp_157070 Schistosoma mansoni (trematode parasite) XP_795729.2 Strongylocentrotus purpuratus (purple sea urchin) 61862 Trichoplax adhaerens (metazoa) XP_971778.1 Tribolium castaneum (red flour beetle) ENSTNIP00000009560 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000003110 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000031785 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33166 modMine - Data generated by the modENCODE project. • FBgn0031217 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10820 NV16663 LH17313 ISCW023134 FBgn0234085 FBgn0226565 FBgn0200291 FBgn0194392 FBgn0171627 JGI_V11_188272 FBgn0071014 FBgn0134453 FBgn0121098 FBgn0116825 FBgn0091889 CPIJ005483 CPIJ000116 BGIBMGA007648 ACYPI002400 GB13112 AGAP007968 AAEL013067 PHUM453010 GLEAN_05174
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG11377 (Keleman et al., 2009.8.5, Easow et al., 2007) CT31762 (Hynes and Zhao, 2000)
Name Synonym
Secondary FlyBase IDs
References ( 13 )
Research paper	Easow et al., 2007, RNA 13(8): 1198--1204 Isolation of microRNA targets by miRNP immunopurification. [FBrf0202410] Giannakou and Dow, 2001, J. exp. Biol. 204(21): 3703--3716 Characterization of the Drosophila melanogaster alkali-metal/proton exchanger (NHE) gene family. [FBrf0141626]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Hynes and Zhao, 2000, J. Cell Biol. 150(2): Table S6. EGF repeat and related adhesion proteins. [FBrf0132110]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]