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Gene Dmel\mRpL10

General Information
Symbol	Dmel\mRpL10	Species	D. melanogaster
Name	mitochondrial ribosomal protein L10	Annotation symbol	CG11488
Feature type	protein_coding_gene	FlyBase ID	FBgn0031231
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	21B4-21B4	Sequence location	2L:203,784..204,782 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mitochondrial ribosomal protein L10 is referred to in FlyBase by the symbol Dmel\mRpL10 (CG11488, FBgn0031231). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of ribosome. Based on sequence similarity, it is predicted to be involved in the biological process: translation. 4 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Ribosomal protein L10/acidic P0. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624012_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mRpL10. Gene sequence location is 2L:203784..204782.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	References Casad et al., 2011, Genetics 189(3): 861--870 Sequence features BKN22415
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21B4-21B4   Limits computationally determined from genome sequence between P{lacW}spenk06805&P{lacW}l(2)k13604k13604 and P{lacW}U2af38k14504
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mRpL10 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mRpL10-RA FBtr0078124  NM_078716   898   248
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mRpL10-PA   FBpp0077783   28.3   248   10.68     NP_523440   AAF51533
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L10/acidic P0 (IPR001790)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695277   AA802214   AE014134 AAF51533   AW941204   AY060877 AAL28425   AY113438 AAM29443   BI229883   BI230545   BI352293   BI614827   BI624813   CO177986   CO189517   CO273298   CO330971   EC069313   EC197997   EC216367   EC230194   EV579834   EV580879   EV595523   GH739135   GH739666   GH740009   GH740319   GH740690   GH742834   GH743151   GH743488   GH743579   GH743588   GH745363   GH745560   GH745909   GH761647   GH762149   GH763100   GH763818   GH763947   GH765113   GH765246   GH765330   GH766274   GH766403   GH766969   GH767045   GH767897   GH768284   GH768634   GH769104   GH769247   GH779618   GH779809   GO254568   GO254574
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VPL3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031231    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031231 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031231 expression level Developmental Stage   Expression Level embryo 00-02hr    6130 embryo 02-04hr    2601 embryo 04-06hr    1160 embryo 06-08hr    1112 embryo 08-10hr    1839 embryo 10-12hr    5095 embryo 12-14hr    3347 embryo 14-16hr    4144 embryo 16-18hr    3724 embryo 18-20hr    3141 embryo 20-22hr    2854 embryo 22-24hr    2610 larva L1    4447 larva L2    5614 larva L3 12hr old    3953 larva L3 puffstage 1-2    1814 larva L3 puffstage 3-6    1370 larva L3 puffstage 7-9    1576 white prepupae new    1251 white prepupae 12hr    1088 white prepupae 24hr    1223 pupae 2d postWPP    2306 pupae 3d postWPP    2836 pupae 4d postWPP    1598 adult male 01day    2281 adult male 05day    2082 adult male 30day    1861 adult female 01day    3213 adult female 05day    4333 adult female 30day    4520 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6130) embryo 02-04hr  (2601) embryo 04-06hr  (1160) embryo 06-08hr  (1112) embryo 08-10hr  (1839) embryo 10-12hr  (5095) embryo 12-14hr  (3347) embryo 14-16hr  (4144) embryo 16-18hr  (3724) embryo 18-20hr  (3141) embryo 20-22hr  (2854) embryo 22-24hr  (2610) larva L1  (4447) larva L2  (5614) larva L3 12hr old  (3953) larva L3 puffstage 1-2  (1814) larva L3 puffstage 3-6  (1370) larva L3 puffstage 7-9  (1576) white prepupae new  (1251) white prepupae 12hr  (1088) white prepupae 24hr  (1223) pupae 2d postWPP  (2306) pupae 3d postWPP  (2836) pupae 4d postWPP  (1598) adult male 01day  (2281) adult male 05day  (2082) adult male 30day  (1861) adult female 01day  (3213) adult female 05day  (4333) adult female 30day  (4520) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6130) embryo 02-04hr  (2601) embryo 04-06hr    1160 embryo 06-08hr    1112 embryo 08-10hr  (1839) embryo 10-12hr  (5095) embryo 12-14hr  (3347) embryo 14-16hr  (4144) embryo 16-18hr  (3724) embryo 18-20hr  (3141) embryo 20-22hr  (2854) embryo 22-24hr  (2610) larva L1  (4447) larva L2  (5614) larva L3 12hr old  (3953) larva L3 puffstage 1-2  (1814) larva L3 puffstage 3-6    1370 larva L3 puffstage 7-9  (1576) white prepupae new    1251 white prepupae 12hr    1088 white prepupae 24hr    1223 pupae 2d postWPP  (2306) pupae 3d postWPP  (2836) pupae 4d postWPP  (1598) adult male 01day  (2281) adult male 05day  (2082) adult male 30day  (1861) adult female 01day  (3213) adult female 05day  (4333) adult female 30day  (4520) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6130 embryo 02-04hr    2601 embryo 04-06hr    1160 embryo 06-08hr    1112 embryo 08-10hr    1839 embryo 10-12hr    5095 embryo 12-14hr    3347 embryo 14-16hr    4144 embryo 16-18hr    3724 embryo 18-20hr    3141 embryo 20-22hr    2854 embryo 22-24hr    2610 larva L1    4447 larva L2    5614 larva L3 12hr old    3953 larva L3 puffstage 1-2    1814 larva L3 puffstage 3-6    1370 larva L3 puffstage 7-9    1576 white prepupae new    1251 white prepupae 12hr    1088 white prepupae 24hr    1223 pupae 2d postWPP    2306 pupae 3d postWPP    2836 pupae 4d postWPP    1598 adult male 01day    2281 adult male 05day    2082 adult male 30day    1861 adult female 01day    3213 adult female 05day    4333 adult female 30day    4520 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6130 embryo 02-04hr    2601 embryo 04-06hr    1160 embryo 06-08hr    1112 embryo 08-10hr    1839 embryo 10-12hr    5095 embryo 12-14hr    3347 embryo 14-16hr    4144 embryo 16-18hr    3724 embryo 18-20hr    3141 embryo 20-22hr    2854 embryo 22-24hr    2610 larva L1    4447 larva L2    5614 larva L3 12hr old    3953 larva L3 puffstage 1-2    1814 larva L3 puffstage 3-6    1370 larva L3 puffstage 7-9    1576 white prepupae new    1251 white prepupae 12hr    1088 white prepupae 24hr    1223 pupae 2d postWPP    2306 pupae 3d postWPP    2836 pupae 4d postWPP    1598 adult male 01day    2281 adult male 05day    2082 adult male 30day    1861 adult female 01day    3213 adult female 05day    4333 adult female 30day    4520 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031231 expression level Developmental Stage   Expression Level embryo 00-02hr    6130 embryo 02-04hr    2601 embryo 04-06hr    1160 embryo 06-08hr    1112 embryo 08-10hr    1839 embryo 10-12hr    5095 embryo 12-14hr    3347 embryo 14-16hr    4144 embryo 16-18hr    3724 embryo 18-20hr    3141 embryo 20-22hr    2854 embryo 22-24hr    2610 larva L1    4447 larva L2    5614 larva L3 12hr old    3953 larva L3 puffstage 1-2    1814 larva L3 puffstage 3-6    1370 larva L3 puffstage 7-9    1576 white prepupae new    1251 white prepupae 12hr    1088 white prepupae 24hr    1223 pupae 2d postWPP    2306 pupae 3d postWPP    2836 pupae 4d postWPP    1598 adult male 01day    2281 adult male 05day    2082 adult male 30day    1861 adult female 01day    3213 adult female 05day    4333 adult female 30day    4520 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6130) embryo 02-04hr  (2601) embryo 04-06hr  (1160) embryo 06-08hr  (1112) embryo 08-10hr  (1839) embryo 10-12hr  (5095) embryo 12-14hr  (3347) embryo 14-16hr  (4144) embryo 16-18hr  (3724) embryo 18-20hr  (3141) embryo 20-22hr  (2854) embryo 22-24hr  (2610) larva L1  (4447) larva L2  (5614) larva L3 12hr old  (3953) larva L3 puffstage 1-2  (1814) larva L3 puffstage 3-6  (1370) larva L3 puffstage 7-9  (1576) white prepupae new  (1251) white prepupae 12hr  (1088) white prepupae 24hr  (1223) pupae 2d postWPP  (2306) pupae 3d postWPP  (2836) pupae 4d postWPP  (1598) adult male 01day  (2281) adult male 05day  (2082) adult male 30day  (1861) adult female 01day  (3213) adult female 05day  (4333) adult female 30day  (4520) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6130) embryo 02-04hr  (2601) embryo 04-06hr    1160 embryo 06-08hr    1112 embryo 08-10hr  1839 embryo 10-12hr  (5095) embryo 12-14hr  (3347) embryo 14-16hr  (4144) embryo 16-18hr  (3724) embryo 18-20hr  (3141) embryo 20-22hr  (2854) embryo 22-24hr  (2610) larva L1  (4447) larva L2  (5614) larva L3 12hr old  (3953) larva L3 puffstage 1-2  1814 larva L3 puffstage 3-6    1370 larva L3 puffstage 7-9  1576 white prepupae new    1251 white prepupae 12hr    1088 white prepupae 24hr    1223 pupae 2d postWPP  2306 pupae 3d postWPP  (2836) pupae 4d postWPP  1598 adult male 01day  2281 adult male 05day  2082 adult male 30day  1861 adult female 01day  (3213) adult female 05day  (4333) adult female 30day  (4520) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6130 embryo 02-04hr    2601 embryo 04-06hr    1160 embryo 06-08hr    1112 embryo 08-10hr    1839 embryo 10-12hr    5095 embryo 12-14hr    3347 embryo 14-16hr    4144 embryo 16-18hr    3724 embryo 18-20hr    3141 embryo 20-22hr    2854 embryo 22-24hr    2610 larva L1    4447 larva L2    5614 larva L3 12hr old    3953 larva L3 puffstage 1-2    1814 larva L3 puffstage 3-6    1370 larva L3 puffstage 7-9    1576 white prepupae new    1251 white prepupae 12hr    1088 white prepupae 24hr    1223 pupae 2d postWPP    2306 pupae 3d postWPP    2836 pupae 4d postWPP    1598 adult male 01day    2281 adult male 05day    2082 adult male 30day    1861 adult female 01day    3213 adult female 05day    4333 adult female 30day    4520 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6130 embryo 02-04hr    2601 embryo 04-06hr    1160 embryo 06-08hr    1112 embryo 08-10hr    1839 embryo 10-12hr    5095 embryo 12-14hr    3347 embryo 14-16hr    4144 embryo 16-18hr    3724 embryo 18-20hr    3141 embryo 20-22hr    2854 embryo 22-24hr    2610 larva L1    4447 larva L2    5614 larva L3 12hr old    3953 larva L3 puffstage 1-2    1814 larva L3 puffstage 3-6    1370 larva L3 puffstage 7-9    1576 white prepupae new    1251 white prepupae 12hr    1088 white prepupae 24hr    1223 pupae 2d postWPP    2306 pupae 3d postWPP    2836 pupae 4d postWPP    1598 adult male 01day    2281 adult male 05day    2082 adult male 30day    1861 adult female 01day    3213 adult female 05day    4333 adult female 30day    4520 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031231    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031231 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031231 expression level Tissue   Expression Level Larval Central Nervous System    201.1 Larval Midgut    288.7 Larval Hindgut    287.1 Larval Malpighian Tubules    220.2 Larval Fat Body    138.8 Larval Salivary Gland    233.8 Larval Trachea    235.575 Larval Carcass    266.975 Adult Head    242.1 Adult Eye    333.3 Adult Brain    297 Adult Thoracic-Abdominal Ganglion    319.8 Adult Crop    268 Adult Midgut    343.9 Adult Hindgut    400.3 Adult Malpighian Tubules    343 Adult Fat Body    235.9 Adult Salivary Gland    173.5 Adult Heart    258.525 Adult VirginFemale Spermatheca    181.8 Adult InseminatedFemale Spermatheca    200.6 Adult Ovary    471.9 Adult Testis    122.2 Adult Male Accessory Gland    121.9 Adult Carcass    275.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    201.1 Larval Midgut    288.7 Larval Hindgut    287.1 Larval Malpighian Tubules    220.2 Larval Fat Body    138.8 Larval Salivary Gland    233.8 Larval Trachea    235.575 Larval Carcass    266.975 Adult Head    242.1 Adult Eye    333.3 Adult Brain    297 Adult Thoracic-Abdominal Ganglion    319.8 Adult Crop    268 Adult Midgut    343.9 Adult Hindgut    400.3 Adult Malpighian Tubules    343 Adult Fat Body    235.9 Adult Salivary Gland    173.5 Adult Heart    258.525 Adult VirginFemale Spermatheca    181.8 Adult InseminatedFemale Spermatheca    200.6 Adult Ovary    471.9 Adult Testis    122.2 Adult Male Accessory Gland    121.9 Adult Carcass    275.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    201.1 Larval Midgut    288.7 Larval Hindgut    287.1 Larval Malpighian Tubules    220.2 Larval Fat Body    138.8 Larval Salivary Gland    233.8 Larval Trachea    235.575 Larval Carcass    266.975 Adult Head    242.1 Adult Eye    333.3 Adult Brain    297 Adult Thoracic-Abdominal Ganglion    319.8 Adult Crop    268 Adult Midgut    343.9 Adult Hindgut    400.3 Adult Malpighian Tubules    343 Adult Fat Body    235.9 Adult Salivary Gland    173.5 Adult Heart    258.525 Adult VirginFemale Spermatheca    181.8 Adult InseminatedFemale Spermatheca    200.6 Adult Ovary    471.9 Adult Testis    122.2 Adult Male Accessory Gland    121.9 Adult Carcass    275.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    201.1 Larval Midgut    288.7 Larval Hindgut    287.1 Larval Malpighian Tubules    220.2 Larval Fat Body    138.8 Larval Salivary Gland    233.8 Larval Trachea    235.575 Larval Carcass    266.975 Adult Head    242.1 Adult Eye    333.3 Adult Brain    297 Adult Thoracic-Abdominal Ganglion    319.8 Adult Crop    268 Adult Midgut    343.9 Adult Hindgut    400.3 Adult Malpighian Tubules    343 Adult Fat Body    235.9 Adult Salivary Gland    173.5 Adult Heart    258.525 Adult VirginFemale Spermatheca    181.8 Adult InseminatedFemale Spermatheca    200.6 Adult Ovary    471.9 Adult Testis    122.2 Adult Male Accessory Gland    121.9 Adult Carcass    275.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031231 expression level Tissue   Expression Level Larval Central Nervous System    201.1 Larval Midgut    288.7 Larval Hindgut    287.1 Larval Malpighian Tubules    220.2 Larval Fat Body    138.8 Larval Salivary Gland    233.8 Larval Trachea    235.575 Larval Carcass    266.975 Adult Head    242.1 Adult Eye    333.3 Adult Brain    297 Adult Thoracic-Abdominal Ganglion    319.8 Adult Crop    268 Adult Midgut    343.9 Adult Hindgut    400.3 Adult Malpighian Tubules    343 Adult Fat Body    235.9 Adult Salivary Gland    173.5 Adult Heart    258.525 Adult VirginFemale Spermatheca    181.8 Adult InseminatedFemale Spermatheca    200.6 Adult Ovary    471.9 Adult Testis    122.2 Adult Male Accessory Gland    121.9 Adult Carcass    275.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    201.1 Larval Midgut    288.7 Larval Hindgut    287.1 Larval Malpighian Tubules    220.2 Larval Fat Body    138.8 Larval Salivary Gland    233.8 Larval Trachea    235.575 Larval Carcass    266.975 Adult Head    242.1 Adult Eye    333.3 Adult Brain    297 Adult Thoracic-Abdominal Ganglion    319.8 Adult Crop    268 Adult Midgut    343.9 Adult Hindgut    400.3 Adult Malpighian Tubules    343 Adult Fat Body    235.9 Adult Salivary Gland    173.5 Adult Heart    258.525 Adult VirginFemale Spermatheca    181.8 Adult InseminatedFemale Spermatheca    200.6 Adult Ovary    471.9 Adult Testis    122.2 Adult Male Accessory Gland    121.9 Adult Carcass    275.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    201.1 Larval Midgut    288.7 Larval Hindgut    287.1 Larval Malpighian Tubules    220.2 Larval Fat Body    138.8 Larval Salivary Gland    233.8 Larval Trachea    235.575 Larval Carcass    266.975 Adult Head    242.1 Adult Eye    333.3 Adult Brain    297 Adult Thoracic-Abdominal Ganglion    319.8 Adult Crop    268 Adult Midgut    343.9 Adult Hindgut    400.3 Adult Malpighian Tubules    343 Adult Fat Body    235.9 Adult Salivary Gland    173.5 Adult Heart    258.525 Adult VirginFemale Spermatheca    181.8 Adult InseminatedFemale Spermatheca    200.6 Adult Ovary    471.9 Adult Testis    122.2 Adult Male Accessory Gland    121.9 Adult Carcass    275.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    201.1 Larval Midgut    288.7 Larval Hindgut    287.1 Larval Malpighian Tubules    220.2 Larval Fat Body    138.8 Larval Salivary Gland    233.8 Larval Trachea    235.575 Larval Carcass    266.975 Adult Head    242.1 Adult Eye    333.3 Adult Brain    297 Adult Thoracic-Abdominal Ganglion    319.8 Adult Crop    268 Adult Midgut    343.9 Adult Hindgut    400.3 Adult Malpighian Tubules    343 Adult Fat Body    235.9 Adult Salivary Gland    173.5 Adult Heart    258.525 Adult VirginFemale Spermatheca    181.8 Adult InseminatedFemale Spermatheca    200.6 Adult Ovary    471.9 Adult Testis    122.2 Adult Male Accessory Gland    121.9 Adult Carcass    275.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    242.1   NA  Eye    333.3   NA  Brain    297   201.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    319.8   NA  Crop    268   288.7  Midgut    343.9   287.1  Hindgut    400.3   220.2  Malpighian Tubules    343   138.8  Fat Body    235.9   233.8  Salivary Gland    173.5   NA  Heart    258.525   235.575  Trachea    NA   NA  VirginFemale Spermatheca    181.8   NA  InseminatedFemale Spermatheca    200.6   NA  Ovary    471.9   NA  Testis    122.2   NA  Male Accessory Gland    121.9   266.975  Carcass    275.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_19
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031231 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11488-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 mRpL10GD7312 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 mRpL10GD7312 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 mRpL10GD7312
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of mRpL10 Class Mutagen Stocks Known lesion mRpL10G19589 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mRpL10 Class Mutagen Stocks Known lesion mRpL10GD7312 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mRpL10KK102349 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mRpL10GD16991 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7002 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7312} NA P{GD16991} NA P{KK102349} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}mRpL10G19589 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from sequence or structural similarity with EMBL:AW249086 (Suzuki et al., 2001) inferred from sequence or structural similarity with UniProtKB:Q3MHY7 (assigned by UniProtKB) (FBrf0198818)
Biological Process
CV term Evidence References
ribosome biogenesis inferred from electronic annotation with InterPro:IPR001790 (FlyBase Curators et al., 2004-) translation inferred from sequence or structural similarity with EMBL:AW249086 (Suzuki et al., 2001) inferred from sequence or structural similarity with UniProtKB:Q3MHY7 (assigned by UniProtKB) (FBrf0198818)
Cellular Component
CV term Evidence References
mitochondrial large ribosomal subunit inferred from sequence or structural similarity with EMBL:AW249086 (Suzuki et al., 2001) inferred from sequence or structural similarity with UniProtKB:Q3MHY7 (assigned by UniProtKB) (FBrf0198818) ribonucleoprotein complex inferred from sequence or structural similarity with UniProtKB:Q3MHY7 (assigned by UniProtKB) (FBrf0198818)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mRpL10 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0031231 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33182
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20722 Dere\GG24703 Dgri\GH11540 Dmoj\GI17030 Dpse\GA11028 Dsec\GM16723 Dsim\GD23008 Dvir\GJ24613 Dwil\GK23913 Dyak\GE16648
Curated drosophilid orthologs	Dpse\GA11028
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009431-PA Aedes aegypti (mosquito) AGAP009988-PA Anopheles gambiae (mosquito) 117089 Branchiostoma floridae (lancelet) 131959 Branchiostoma floridae (lancelet) XP_001902818.1 Brugia malayi (roundworm nematode) ENSBTAP00000002395 Bos taurus (bovine) CAL0001313 Candida albicans (a form of yeast) CN07890 Caenorhabditis brenneri (small nematode) CBP05769 Caenorhabditis briggsae (nematode) CE02267 Caenorhabditis elegans (worm) ENSCAFP00000024707 Canis familiaris (dog) JA00470 Caenorhabditis japonica (nematode) CPIJ003110 Culex pipens (mosquito) ENSCPOP00000006244 Cavia porcellus (guinea pig) RP35646 Caenorhabditis remanei (nematode) 223105 Capitella spl (polychaete worm) 308442 Daphnia pulex (daphnia) ENSDARP00000066302 Danio rerio (zebra fish) ENSECAP00000005063 Equus caballus (horse) ENSGACP00000005047 Gymnopilus aculeatus (mushroom) ENSGALP00000023202 Gallus gallus (chicken) 190136 Hypsipyla robusta (cedar shoot borer) ENSP00000290208 Homo sapiens (human) ISCW021101-PA Ixodes scapularis (deer tick) 239114 Lottia gigantea (owl limpet) ENSMODP00000015614 Monodelphis domestica (gray opossum) ENSMMUP00000028305 Macaca mulatta (rhesus monkey) ENSMUSP00000001485 Mus musculus (house mouse) XP_001601336.1 Nasonia vitripennis (wasp) ENSOANP00000010845 Ornithorynchus anatinus (platypus) ENSORLP00000015343 Oryzias latipes (japanese killifish) PHUM009996-PA Pediculus humanus (human body louse) PP14892 Pristionchus pacificus (nematode) ENSPPYP00000009959 Pongo pygmaeus (orangutan) ENSPTRP00000015873 Pan troglodytes (chimpanzee) ENSRNOP00000013115 Rattus norvegicus (norway rat) Smp_085780 Schistosoma mansoni (trematode parasite) XP_001190935.1 Strongylocentrotus purpuratus (purple sea urchin) 54455 Trichoplax adhaerens (metazoa) XP_969776.1 Tribolium castaneum (red flour beetle) ENSTNIP00000000942 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031702 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000032320 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12876 ISCW021101 FBgn0234146 FBgn0225875 FBgn0211691 FBgn0194400 FBgn0171636 JGI_V11_308442 FBgn0071084 FBgn0139775 FBgn0119020 FBgn0116834 FBgn0097728 CPIJ003110 ACYPI32743 AGAP009988 AAEL009431 PHUM462620 GLEAN_14272
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	26969 y1 w*; P{EP}mRpL10G19589/CyO
VDRC	v105994 P{KK102349}VIE-260B v31508 w1118; P{GD7312}v31508 v32500 w1118; P{GD7312}v32500
Genomic Clones ( 1 )
	BACR22C14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 48 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM04029 RE27758
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM02529 GM18682 RE14245 RH44307 RH64512
Other clones	Dmel_dig_003289_0677_3073 Dmel_dig_015663_0599_3211 Dmel_neb_004978_0601_3569 EK044440 EK054920 EK110416 EK296741 RP01069 RP01071 RP001002228 RP001004734 RP001006752 RP001007421 RP001007566 RP001010529 RP001012925 RP001013293 RP001013703 RP001016309 RP001017026 RP001017663 RP001019401 RP001021072 RP001021352 RP001021416 RP001023600 RP001023822 RP001024035 RP001026048 RP001026259 RP001027761 RP001030293 RP001032926 RP001033507 RP001036035 RP001037998 RP001040380 RP001041741 RP001042109 RP001044032 RP001053864
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031231 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33182
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mRpL10 CG11488 (Suzuki et al., 2001)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078716 RefSeq (Proteins) • NP_523440 DDBJ / EMBL / GenBank • AA802214 AAF51533 AAL28425 AAM29443 AW941204 AY060877 AY113438 BI229883 Entrez Gene - A searchable database of RefSeq genes. • 33182 UniProtKB/TrEMBL • Q9VPL3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L10/acidic P0 (IPR001790)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0031231 DRSC - Results from RNAi screens. • FBgn0031231 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031231 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11488-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031231 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33182 InParanoid A subset of ortholog calls from InParanoid. • AAEL009431-PA Aedes aegypti (mosquito) AGAP009988-PA Anopheles gambiae (mosquito) 117089 Branchiostoma floridae (lancelet) 131959 Branchiostoma floridae (lancelet) XP_001902818.1 Brugia malayi (roundworm nematode) ENSBTAP00000002395 Bos taurus (bovine) CAL0001313 Candida albicans (a form of yeast) CN07890 Caenorhabditis brenneri (small nematode) CBP05769 Caenorhabditis briggsae (nematode) CE02267 Caenorhabditis elegans (worm) ENSCAFP00000024707 Canis familiaris (dog) JA00470 Caenorhabditis japonica (nematode) CPIJ003110 Culex pipens (mosquito) ENSCPOP00000006244 Cavia porcellus (guinea pig) RP35646 Caenorhabditis remanei (nematode) 223105 Capitella spl (polychaete worm) 308442 Daphnia pulex (daphnia) ENSDARP00000066302 Danio rerio (zebra fish) ENSECAP00000005063 Equus caballus (horse) ENSGACP00000005047 Gymnopilus aculeatus (mushroom) ENSGALP00000023202 Gallus gallus (chicken) 190136 Hypsipyla robusta (cedar shoot borer) ENSP00000290208 Homo sapiens (human) ISCW021101-PA Ixodes scapularis (deer tick) 239114 Lottia gigantea (owl limpet) ENSMODP00000015614 Monodelphis domestica (gray opossum) ENSMMUP00000028305 Macaca mulatta (rhesus monkey) ENSMUSP00000001485 Mus musculus (house mouse) XP_001601336.1 Nasonia vitripennis (wasp) ENSOANP00000010845 Ornithorynchus anatinus (platypus) ENSORLP00000015343 Oryzias latipes (japanese killifish) PHUM009996-PA Pediculus humanus (human body louse) PP14892 Pristionchus pacificus (nematode) ENSPPYP00000009959 Pongo pygmaeus (orangutan) ENSPTRP00000015873 Pan troglodytes (chimpanzee) ENSRNOP00000013115 Rattus norvegicus (norway rat) Smp_085780 Schistosoma mansoni (trematode parasite) XP_001190935.1 Strongylocentrotus purpuratus (purple sea urchin) 54455 Trichoplax adhaerens (metazoa) XP_969776.1 Tribolium castaneum (red flour beetle) ENSTNIP00000000942 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031702 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000032320 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33182 modMine - Data generated by the modENCODE project. • FBgn0031231 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12876 ISCW021101 FBgn0234146 FBgn0225875 FBgn0211691 FBgn0194400 FBgn0171636 JGI_V11_308442 FBgn0071084 FBgn0139775 FBgn0119020 FBgn0116834 FBgn0097728 CPIJ003110 ACYPI32743 AGAP009988 AAEL009431 PHUM462620 GLEAN_14272
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG11488 (Suzuki et al., 2001, Keleman et al., 2009.8.5, Marygold et al., 2007, Cammarato et al., 2011) L10 (Suzuki et al., 2001) mRpL10 (FBrf0198818, Marygold et al., 2007, Hoskins et al., 2011)
Name Synonym	mitochondrial ribosomal protein L10 (Suzuki et al., 2001, Cammarato et al., 2011)
Secondary FlyBase IDs
References ( 17 )
Research paper	Casad et al., 2011, Genetics 189(3): 861--870 Cardiomyopathy Is Associated with Ribosomal Protein Gene Haplo-Insufficiency in Drosophila melanogaster. [FBrf0216591] Hoskins et al., 2011, Genome Res. 21(2): 182--192 Genome-wide analysis of promoter architecture in Drosophila melanogaster. [FBrf0213090] Marygold et al., 2007, Genome Biol. 8(10): R216 The ribosomal protein genes and Minute loci of Drosophila melanogaster. [FBrf0205398] Orian et al., 2003, Genes Dev. 17(9): 1101--1114 Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. [FBrf0158942] Suzuki et al., 2001, J. Biol. Chem. 276(24): 21724--21736 Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. [FBrf0136752]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579]
Personal communication to FlyBase	Bellen, 2009.2.6, BDGP_2009_0206.GenExel.xml BDGP_2009_0206.GenExel.xml [FBrf0206623] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
Protein sequence record	39S ribosomal protein L10, mitochondrial precursor (L10mt) (MRP-L10). [FBrf0198818]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]