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Gene Dmel\Spp

General Information
Symbol	Dmel\Spp	Species	D. melanogaster
Name	Signal peptide protease	Annotation symbol	CG11840
Feature type	protein_coding_gene	FlyBase ID	FBgn0031260
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	21E2-21E2	Sequence location	2L:542,776..544,627 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Signal peptide protease is referred to in FlyBase by the symbol Dmel\Spp (CG11840, FBgn0031260). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: aspartic endopeptidase activity, intramembrane cleaving. There is experimental evidence that it is involved in the biological process: membrane protein proteolysis; open tracheal system development. 16 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; heart primordium; embryonic/larval tracheal system. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase A22, presenilin signal peptide; Peptidase A22B, signal peptide peptidase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, larval Malpighian tubules, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1636639_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Spp. Gene sequence location is 2L:542776..544627.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA00328 BKN20695
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21E2-21E2   Limits computationally determined from genome sequence between P{lacW}l(2)k09610k09610&P{lacW}Sk09538a and P{PZ}l(2)1068510685&P{lacW}Tango14k00619
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Spp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Spp-RA FBtr0078080  NM_078720   1720   389
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Spp-PA   FBpp0077740   43.2   389   9.88     NP_523444   AAF51486
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase A22, presenilin signal peptide (IPR006639) Peptidase A22B, signal peptide peptidase (IPR007369)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140716   AA264424   AA264599   AA264752   AA391990   AA536436   AA540994   AA817313   AA979607   AA990678   AE014134 AAF51486   AI063270   AI259950   AI456406   AI531599   AI531600   AI533172   AI534365   AI534608   AI542183   AI543050   AW944507   AY070713 AAL48184   BE662194   BF506643   BG636718   BG637516   BG640895   BG640940   BI141717   BI141737   BI173320   BI173735   BI213139   BI216434   BI216617   BI229728   BI234661   BI235538   BI235640   BI237768   BI237884   BI238132   BI238195   BI356512   BI361530   BI361531   BI361763   BI364235   BI365817   BI366139   BI371523   BI375364   BI579663   BI635115   BI635138   BI638142   BI638888   BI639228   BI639524   CK657702   CO153550   CO156744   CO194411   CO268057   CO281645   CO298354   CO336669   CO336752   CO336849   EC061975   EC062227   EC197105   EC210305   EC261252   EC263118   EC263281   EC263671   EC265129   EC267844   EL871548   EL871549   EL871659   EL871660   EV587337   GH743937   GH744147   GH745051   GH762299   GH767556   GH768107
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VPQ7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 15   salivary gland body primordium   (Casso et al., 2005) embryonic stage 13 -- 15   epidermal cell of metameric furrow   (Casso et al., 2005) embryonic somatic muscle   (Casso et al., 2005) embryonic proventriculus   (Casso et al., 2005) embryonic stage 16 -- 17   presumptive embryonic salivary gland   (Casso et al., 2005) tracheal branch primordium   (Casso et al., 2005) third instar larval stage   embryonic/larval salivary gland duct   (Casso et al., 2005) wing disc   (Casso et al., 2005) ventral thoracic disc   (Casso et al., 2005)
Additional Descriptive Data
	Spp transcript is expressed in the invaginating salivary gland placodes during germ band extension; expression continues in the developing salivary gland throughout embryogenesis. In dorsal closure embryos, Spp transcript is expressed proventriculus, in the somatic musculature, and in epidermal cells adjacent to segmental involutions. In late-stage embryos, Spp is expressed in the salivary glands and in tracheal branches. In third instar larvae, Spp transcript is prominently expressed in duct cells of the salivary gland, and in a nonuniform pattern in the wing and leg imaginal discs. (Casso et al., 2005)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
epitope tag Stage Tissue/Position (including subcellular localization) Reference   cell   • nuclear outer membrane & endoplasmic reticulum (Casso et al., 2005) Comment:assayed in S2 cells
Additional Descriptive Data
	Myc-tagged Spp protein is distributed in a perinuclear ring and in a lacy reticular pattern in S2 cells. (Casso et al., 2005)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031260    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031260 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031260 expression level Developmental Stage   Expression Level embryo 00-02hr    6961 embryo 02-04hr    10849 embryo 04-06hr    11253 embryo 06-08hr    13666 embryo 08-10hr    15689 embryo 10-12hr    20499 embryo 12-14hr    14399 embryo 14-16hr    16625 embryo 16-18hr    9898 embryo 18-20hr    5101 embryo 20-22hr    3955 embryo 22-24hr    3539 larva L1    7814 larva L2    15120 larva L3 12hr old    10482 larva L3 puffstage 1-2    6642 larva L3 puffstage 3-6    6052 larva L3 puffstage 7-9    6154 white prepupae new    7075 white prepupae 12hr    3227 white prepupae 24hr    5274 pupae 2d postWPP    5731 pupae 3d postWPP    2750 pupae 4d postWPP    3919 adult male 01day    6835 adult male 05day    7734 adult male 30day    9644 adult female 01day    6560 adult female 05day    7807 adult female 30day    7621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6961) embryo 02-04hr  (10849) embryo 04-06hr  (11253) embryo 06-08hr  (13666) embryo 08-10hr  (15689) embryo 10-12hr  (20499) embryo 12-14hr  (14399) embryo 14-16hr  (16625) embryo 16-18hr  (9898) embryo 18-20hr  (5101) embryo 20-22hr  (3955) embryo 22-24hr  (3539) larva L1  (7814) larva L2  (15120) larva L3 12hr old  (10482) larva L3 puffstage 1-2  (6642) larva L3 puffstage 3-6  (6052) larva L3 puffstage 7-9  (6154) white prepupae new  (7075) white prepupae 12hr  (3227) white prepupae 24hr  (5274) pupae 2d postWPP  (5731) pupae 3d postWPP  (2750) pupae 4d postWPP  (3919) adult male 01day  (6835) adult male 05day  (7734) adult male 30day  (9644) adult female 01day  (6560) adult female 05day  (7807) adult female 30day  (7621) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6961) embryo 02-04hr  (10849) embryo 04-06hr  (11253) embryo 06-08hr  (13666) embryo 08-10hr  (15689) embryo 10-12hr  (20499) embryo 12-14hr  (14399) embryo 14-16hr  (16625) embryo 16-18hr  (9898) embryo 18-20hr  (5101) embryo 20-22hr  (3955) embryo 22-24hr  (3539) larva L1  (7814) larva L2  (15120) larva L3 12hr old  (10482) larva L3 puffstage 1-2  (6642) larva L3 puffstage 3-6  (6052) larva L3 puffstage 7-9  (6154) white prepupae new  (7075) white prepupae 12hr  (3227) white prepupae 24hr  (5274) pupae 2d postWPP  (5731) pupae 3d postWPP  (2750) pupae 4d postWPP  (3919) adult male 01day  (6835) adult male 05day  (7734) adult male 30day  (9644) adult female 01day  (6560) adult female 05day  (7807) adult female 30day  (7621) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6961 embryo 02-04hr  (10849) embryo 04-06hr  (11253) embryo 06-08hr  (13666) embryo 08-10hr  (15689) embryo 10-12hr  (20499) embryo 12-14hr  (14399) embryo 14-16hr  (16625) embryo 16-18hr    9898 embryo 18-20hr    5101 embryo 20-22hr    3955 embryo 22-24hr    3539 larva L1    7814 larva L2  (15120) larva L3 12hr old  10482 larva L3 puffstage 1-2    6642 larva L3 puffstage 3-6    6052 larva L3 puffstage 7-9    6154 white prepupae new    7075 white prepupae 12hr    3227 white prepupae 24hr    5274 pupae 2d postWPP    5731 pupae 3d postWPP    2750 pupae 4d postWPP    3919 adult male 01day    6835 adult male 05day    7734 adult male 30day    9644 adult female 01day    6560 adult female 05day    7807 adult female 30day    7621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6961 embryo 02-04hr    10849 embryo 04-06hr    11253 embryo 06-08hr    13666 embryo 08-10hr    15689 embryo 10-12hr    20499 embryo 12-14hr    14399 embryo 14-16hr    16625 embryo 16-18hr    9898 embryo 18-20hr    5101 embryo 20-22hr    3955 embryo 22-24hr    3539 larva L1    7814 larva L2    15120 larva L3 12hr old    10482 larva L3 puffstage 1-2    6642 larva L3 puffstage 3-6    6052 larva L3 puffstage 7-9    6154 white prepupae new    7075 white prepupae 12hr    3227 white prepupae 24hr    5274 pupae 2d postWPP    5731 pupae 3d postWPP    2750 pupae 4d postWPP    3919 adult male 01day    6835 adult male 05day    7734 adult male 30day    9644 adult female 01day    6560 adult female 05day    7807 adult female 30day    7621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031260 expression level Developmental Stage   Expression Level embryo 00-02hr    6961 embryo 02-04hr    10849 embryo 04-06hr    11253 embryo 06-08hr    13666 embryo 08-10hr    15689 embryo 10-12hr    20499 embryo 12-14hr    14399 embryo 14-16hr    16625 embryo 16-18hr    9898 embryo 18-20hr    5101 embryo 20-22hr    3955 embryo 22-24hr    3539 larva L1    7814 larva L2    15120 larva L3 12hr old    10482 larva L3 puffstage 1-2    6642 larva L3 puffstage 3-6    6052 larva L3 puffstage 7-9    6154 white prepupae new    7075 white prepupae 12hr    3227 white prepupae 24hr    5274 pupae 2d postWPP    5731 pupae 3d postWPP    2750 pupae 4d postWPP    3919 adult male 01day    6835 adult male 05day    7734 adult male 30day    9644 adult female 01day    6560 adult female 05day    7807 adult female 30day    7621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6961) embryo 02-04hr  (10849) embryo 04-06hr  (11253) embryo 06-08hr  (13666) embryo 08-10hr  (15689) embryo 10-12hr  (20499) embryo 12-14hr  (14399) embryo 14-16hr  (16625) embryo 16-18hr  (9898) embryo 18-20hr  (5101) embryo 20-22hr  (3955) embryo 22-24hr  (3539) larva L1  (7814) larva L2  (15120) larva L3 12hr old  (10482) larva L3 puffstage 1-2  (6642) larva L3 puffstage 3-6  (6052) larva L3 puffstage 7-9  (6154) white prepupae new  (7075) white prepupae 12hr  (3227) white prepupae 24hr  (5274) pupae 2d postWPP  (5731) pupae 3d postWPP  (2750) pupae 4d postWPP  (3919) adult male 01day  (6835) adult male 05day  (7734) adult male 30day  (9644) adult female 01day  (6560) adult female 05day  (7807) adult female 30day  (7621) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6961) embryo 02-04hr  (10849) embryo 04-06hr  (11253) embryo 06-08hr  (13666) embryo 08-10hr  (15689) embryo 10-12hr  (20499) embryo 12-14hr  (14399) embryo 14-16hr  (16625) embryo 16-18hr  (9898) embryo 18-20hr  (5101) embryo 20-22hr  (3955) embryo 22-24hr  (3539) larva L1  (7814) larva L2  (15120) larva L3 12hr old  (10482) larva L3 puffstage 1-2  (6642) larva L3 puffstage 3-6  (6052) larva L3 puffstage 7-9  (6154) white prepupae new  (7075) white prepupae 12hr  (3227) white prepupae 24hr  (5274) pupae 2d postWPP  (5731) pupae 3d postWPP  (2750) pupae 4d postWPP  (3919) adult male 01day  (6835) adult male 05day  (7734) adult male 30day  (9644) adult female 01day  (6560) adult female 05day  (7807) adult female 30day  (7621) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6961 embryo 02-04hr  10849 embryo 04-06hr  11253 embryo 06-08hr  13666 embryo 08-10hr  15689 embryo 10-12hr  20499 embryo 12-14hr  14399 embryo 14-16hr  16625 embryo 16-18hr    9898 embryo 18-20hr    5101 embryo 20-22hr    3955 embryo 22-24hr    3539 larva L1    7814 larva L2  15120 larva L3 12hr old  10482 larva L3 puffstage 1-2    6642 larva L3 puffstage 3-6    6052 larva L3 puffstage 7-9    6154 white prepupae new    7075 white prepupae 12hr    3227 white prepupae 24hr    5274 pupae 2d postWPP    5731 pupae 3d postWPP    2750 pupae 4d postWPP    3919 adult male 01day    6835 adult male 05day    7734 adult male 30day    9644 adult female 01day    6560 adult female 05day    7807 adult female 30day    7621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6961 embryo 02-04hr    10849 embryo 04-06hr    11253 embryo 06-08hr    13666 embryo 08-10hr    15689 embryo 10-12hr    20499 embryo 12-14hr    14399 embryo 14-16hr    16625 embryo 16-18hr    9898 embryo 18-20hr    5101 embryo 20-22hr    3955 embryo 22-24hr    3539 larva L1    7814 larva L2    15120 larva L3 12hr old    10482 larva L3 puffstage 1-2    6642 larva L3 puffstage 3-6    6052 larva L3 puffstage 7-9    6154 white prepupae new    7075 white prepupae 12hr    3227 white prepupae 24hr    5274 pupae 2d postWPP    5731 pupae 3d postWPP    2750 pupae 4d postWPP    3919 adult male 01day    6835 adult male 05day    7734 adult male 30day    9644 adult female 01day    6560 adult female 05day    7807 adult female 30day    7621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031260    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031260 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, larval Malpighian tubules, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031260 expression level Tissue   Expression Level Larval Central Nervous System    471.45 Larval Midgut    588.2 Larval Hindgut    571.6 Larval Malpighian Tubules    475.8 Larval Fat Body    818.8 Larval Salivary Gland    4359.5 Larval Trachea    1019.7 Larval Carcass    874.425 Adult Head    469.7 Adult Eye    255.05 Adult Brain    311 Adult Thoracic-Abdominal Ganglion    363.9 Adult Crop    367.9 Adult Midgut    588.7 Adult Hindgut    353.4 Adult Malpighian Tubules    551.4 Adult Fat Body    962.6 Adult Salivary Gland    4020.3 Adult Heart    604.575 Adult VirginFemale Spermatheca    1811 Adult InseminatedFemale Spermatheca    2060.8 Adult Ovary    487.6 Adult Testis    283.5 Adult Male Accessory Gland    5590.9 Adult Carcass    559.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    471.45 Larval Midgut  (588.2) Larval Hindgut  (571.6) Larval Malpighian Tubules    475.8 Larval Fat Body  (818.8) Larval Salivary Gland  (4359.5) Larval Trachea  (1019.7) Larval Carcass  (874.425) Adult Head    469.7 Adult Eye    255.05 Adult Brain    311 Adult Thoracic-Abdominal Ganglion    363.9 Adult Crop    367.9 Adult Midgut  (588.7) Adult Hindgut    353.4 Adult Malpighian Tubules  (551.4) Adult Fat Body  (962.6) Adult Salivary Gland  (4020.3) Adult Heart  (604.575) Adult VirginFemale Spermatheca  (1811) Adult InseminatedFemale Spermatheca  (2060.8) Adult Ovary    487.6 Adult Testis    283.5 Adult Male Accessory Gland  (5590.9) Adult Carcass  (559.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    471.45 Larval Midgut    588.2 Larval Hindgut    571.6 Larval Malpighian Tubules    475.8 Larval Fat Body    818.8 Larval Salivary Gland  (4359.5) Larval Trachea  1019.7 Larval Carcass    874.425 Adult Head    469.7 Adult Eye    255.05 Adult Brain    311 Adult Thoracic-Abdominal Ganglion    363.9 Adult Crop    367.9 Adult Midgut    588.7 Adult Hindgut    353.4 Adult Malpighian Tubules    551.4 Adult Fat Body    962.6 Adult Salivary Gland  (4020.3) Adult Heart    604.575 Adult VirginFemale Spermatheca  (1811) Adult InseminatedFemale Spermatheca  (2060.8) Adult Ovary    487.6 Adult Testis    283.5 Adult Male Accessory Gland  (5590.9) Adult Carcass    559.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    471.45 Larval Midgut    588.2 Larval Hindgut    571.6 Larval Malpighian Tubules    475.8 Larval Fat Body    818.8 Larval Salivary Gland    4359.5 Larval Trachea    1019.7 Larval Carcass    874.425 Adult Head    469.7 Adult Eye    255.05 Adult Brain    311 Adult Thoracic-Abdominal Ganglion    363.9 Adult Crop    367.9 Adult Midgut    588.7 Adult Hindgut    353.4 Adult Malpighian Tubules    551.4 Adult Fat Body    962.6 Adult Salivary Gland    4020.3 Adult Heart    604.575 Adult VirginFemale Spermatheca    1811 Adult InseminatedFemale Spermatheca    2060.8 Adult Ovary    487.6 Adult Testis    283.5 Adult Male Accessory Gland    5590.9 Adult Carcass    559.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031260 expression level Tissue   Expression Level Larval Central Nervous System    471.45 Larval Midgut    588.2 Larval Hindgut    571.6 Larval Malpighian Tubules    475.8 Larval Fat Body    818.8 Larval Salivary Gland    4359.5 Larval Trachea    1019.7 Larval Carcass    874.425 Adult Head    469.7 Adult Eye    255.05 Adult Brain    311 Adult Thoracic-Abdominal Ganglion    363.9 Adult Crop    367.9 Adult Midgut    588.7 Adult Hindgut    353.4 Adult Malpighian Tubules    551.4 Adult Fat Body    962.6 Adult Salivary Gland    4020.3 Adult Heart    604.575 Adult VirginFemale Spermatheca    1811 Adult InseminatedFemale Spermatheca    2060.8 Adult Ovary    487.6 Adult Testis    283.5 Adult Male Accessory Gland    5590.9 Adult Carcass    559.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    471.45 Larval Midgut  588.2 Larval Hindgut  571.6 Larval Malpighian Tubules    475.8 Larval Fat Body  (818.8) Larval Salivary Gland  (4359.5) Larval Trachea  (1019.7) Larval Carcass  (874.425) Adult Head    469.7 Adult Eye    255.05 Adult Brain    311 Adult Thoracic-Abdominal Ganglion    363.9 Adult Crop    367.9 Adult Midgut  588.7 Adult Hindgut    353.4 Adult Malpighian Tubules  551.4 Adult Fat Body  (962.6) Adult Salivary Gland  (4020.3) Adult Heart  604.575 Adult VirginFemale Spermatheca  (1811) Adult InseminatedFemale Spermatheca  (2060.8) Adult Ovary    487.6 Adult Testis    283.5 Adult Male Accessory Gland  (5590.9) Adult Carcass  559.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    471.45 Larval Midgut    588.2 Larval Hindgut    571.6 Larval Malpighian Tubules    475.8 Larval Fat Body    818.8 Larval Salivary Gland  (4359.5) Larval Trachea  1019.7 Larval Carcass    874.425 Adult Head    469.7 Adult Eye    255.05 Adult Brain    311 Adult Thoracic-Abdominal Ganglion    363.9 Adult Crop    367.9 Adult Midgut    588.7 Adult Hindgut    353.4 Adult Malpighian Tubules    551.4 Adult Fat Body    962.6 Adult Salivary Gland  (4020.3) Adult Heart    604.575 Adult VirginFemale Spermatheca  (1811) Adult InseminatedFemale Spermatheca  (2060.8) Adult Ovary    487.6 Adult Testis    283.5 Adult Male Accessory Gland  (5590.9) Adult Carcass    559.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    471.45 Larval Midgut    588.2 Larval Hindgut    571.6 Larval Malpighian Tubules    475.8 Larval Fat Body    818.8 Larval Salivary Gland    4359.5 Larval Trachea    1019.7 Larval Carcass    874.425 Adult Head    469.7 Adult Eye    255.05 Adult Brain    311 Adult Thoracic-Abdominal Ganglion    363.9 Adult Crop    367.9 Adult Midgut    588.7 Adult Hindgut    353.4 Adult Malpighian Tubules    551.4 Adult Fat Body    962.6 Adult Salivary Gland    4020.3 Adult Heart    604.575 Adult VirginFemale Spermatheca    1811 Adult InseminatedFemale Spermatheca    2060.8 Adult Ovary    487.6 Adult Testis    283.5 Adult Male Accessory Gland    5590.9 Adult Carcass    559.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    469.7   NA  Eye    255.05   NA  Brain    311   471.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    363.9   NA  Crop    367.9   588.2  Midgut    588.7   571.6  Hindgut    353.4   475.8  Malpighian Tubules    551.4   818.8  Fat Body    962.6   4359.5  Salivary Gland    4020.3   NA  Heart    604.575   1019.7  Trachea    NA   NA  VirginFemale Spermatheca    1811   NA  InseminatedFemale Spermatheca    2060.8   NA  Ovary    487.6   NA  Testis    283.5   NA  Male Accessory Gland    5590.9   874.425  Carcass    559.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031260 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11840-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | first instar larval stage | recessive Spp6 lethal | larval stage | recessive Spp5 Spp7 Spp14 viable, with Scer\GAL4pnr-MD237 SppGD786 Other Phenotypes Allele visible, with Scer\GAL4en-e16E SppScer\UAS.cCa visible, with Scer\GAL4pnr-MD237 SppGD786 Phenotype manifest in Allele embryonic/larval tracheal system Spp14 Spp5 Spp6 Spp7 heart primordium SppdsRNA.cKa SppdsRNA.si.cKa trichogen cell, with Scer\GAL4pnr-MD237 SppGD786 wing | posterior compartment, with Scer\GAL4en-e16E SppScer\UAS.cCa
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Spp Class Mutagen Stocks Known lesion Spp5 ethyl methanesulfonate 1 Yes Spp6 ethyl methanesulfonate 1 Yes Spp14 Delta2-3 0 Yes Spp7 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Spp Class Mutagen Stocks Known lesion SppdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes SppGD786 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Spp+t5.3 in vitro construct - genomic fragment 0 Yes SppC.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SppdsRNA.cKa in vitro construct - RNAi 0 Yes SppdsRNA.si.cKa in vitro construct - RNAi 0 Yes SppKK100599 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes SppM.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes SppM in vitro construct - amino acid replacement 0 Yes SppN.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SppScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes Sppt2.4 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(2L)lwr14 (Casso et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD786} NA P{KK100599} NA P{UAS-Spp.C} NA P{UAS-Spp.M} NA P{UAS-Spp.RNAi} NA characterization construct P{SppM} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
aspartic endopeptidase activity, intramembrane cleaving inferred from direct assay (Casso et al., 2005, Narayanan et al., 2007)
Biological Process
CV term Evidence References
membrane protein proteolysis inferred from direct assay (Narayanan et al., 2007) open tracheal system development inferred from mutant phenotype (Casso and Kornberg, 2005)
Cellular Component
CV term Evidence References
endoplasmic reticulum inferred from direct assay (Casso et al., 2005)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
aspartic endopeptidase activity, intramembrane cleaving non-traceable author statement (Weihofen, 2002.7.28)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR006639, InterPro:IPR007369 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Spp allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031260 DroID - A comprehensive database of gene and protein interactions. • FBgn0031260 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33227
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24718 Dere\GG24644 Dgri\GH10510 Dmoj\GI18028 Dper\GL19257 Dpse\GA11227 Dsec\GM16661 Dsim\GD22952 Dvir\GJ19708 Dwil\GK14664 Dyak\GE16062
Curated drosophilid orthologs	Dpse\GA11227   Dpse\GA19664   Dsim\shanti (Swanson et al., 2001)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011989-PA Aedes aegypti (mosquito) AGAP008838-PA Anopheles gambiae (mosquito) XP_393360.2 Apis mellifera (honey bee) XP_001952644.1 Acyrthosiphon pisum (pea aphid) At2g03120.1 Arabidopsis thaliana (wall cress) 33932 Batrachochytrium dendrobatidis (chytrid fungus) 87838 Branchiostoma floridae (lancelet) BGIBMGA004196-PA Bombyx mori (silk worm) ENSBTAP00000011640 Bos taurus (bovine) CN04183 Caenorhabditis brenneri (small nematode) CBP07212 Caenorhabditis briggsae (nematode) CE06364 Caenorhabditis elegans (worm) ENSCAFP00000010466 Canis familiaris (dog) CAGL0K08492g Candida glabrata (haploid yeast) Chro.60109 Cryptosporidium hominis (obligate parasite) ENSCINP00000019835 Ciona intestinalis (sea squirt) JA02708 Caenorhabditis japonica (nematode) CMH005C Cyanidioschyzon merolae (red alga) cn12067 Cryptococcus neoformans (yeast-like fungus) cgd6_840 Cryptosporidium parvum (protozoan parasite) CPIJ000872 Culex pipens (mosquito) ENSCPOP00000010501 Cavia porcellus (guinea pig) 99652 Chlamidomonas reinhardtii (green alga) RP31350 Caenorhabditis remanei (nematode) ENSCSAVP00000013399 Ciona savignyi (sedentary tunicate) 222251 Capitella spl (polychaete worm) DDB0231493 Dictyostelium discoideum (amoeba) DEHA2E19448g Debaryomyces Hansenii (yeast) 303875 Daphnia pulex (daphnia) ENSDARP00000055141 Danio rerio (zebra fish) ENSECAP00000017038 Equus caballus (horse) XP_654079 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000000668 Gymnopilus aculeatus (mushroom) ENSGALP00000010006 Gallus gallus (chicken) GL50803_8429 Giardia lamblia (flagellated protozoan) 187510 Hypsipyla robusta (cedar shoot borer) ENSP00000381237 Homo sapiens (human) ISCW006186-PA Ixodes scapularis (deer tick) 102125 Lottia gigantea (owl limpet) LmjF29.0910 Leishmania major (virus) ENSMODP00000024323 Monodelphis domestica (gray opossum) ENSMMUP00000006786 Macaca mulatta (rhesus monkey) ENSMUSP00000105451 Mus musculus (house mouse) 228311 Nematostella vectensis (starlet anemone) XP_001600867.1 Nasonia vitripennis (wasp) ENSOANP00000003556 Ornithorynchus anatinus (platypus) ENSORLP00000023111 Oryzias latipes (japanese killifish) LOC_Os02g02530.1 Oryza sativa (asian rice) LOC_Os05g36070.1 Oryza sativa (asian rice) 19016 Ostreococcus tauri (green alga) PF14_0543 Plasmodium falciparum (protozoal parasite) PHUM000983-PA Pediculus humanus (human body louse) PP14514 Pristionchus pacificus (nematode) 124035 Physcomitrella patens (moss) 181086 Physcomitrella patens (moss) ENSPPYP00000012161 Pongo pygmaeus (orangutan) 157626 Phytophthora sojae (root rot pathogen) 706551 Populus trichocarpa (black cottonwood) 833167 Populus trichocarpa (black cottonwood) ENSPTRP00000022897 Pan troglodytes (chimpanzee) PVX_117615 Plasmodium vivax (protozoal parasite) ENSRNOP00000010174 Rattus norvegicus (norway rat) 4881781 Sorghum bicolor (sorghum) YKL100C Saccharomyces cerevisiae (budding yeast) SPAC25B8.17 Schizosaccharomyces pombe (fission yeast) 58104 Trichoplax adhaerens (metazoa) XP_967836.1 Tribolium castaneum (red flour beetle) Tc00.1047053507951.260 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000008563 Tetraodon nigroviridis (green spotted pufferfish) 15950 Thalassiosira pseudonana (marine diatom) ENSTRUP00000015369 Takifugu rubripes (pufferfish Takifugu) 145.m00084 Tetrahymena thermophila (ciliate protozoa) 82736.m00170 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000051796 Xenopus tropicalis (frog) YALI0C04818g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16174 NV18122 LH20947 ISCW006186 FBgn0233612 FBgn0216670 FBgn0206850 FBgn0194346 FBgn0171574 JGI_V11_303875 FBgn0071281 FBgn0156856 FBgn0140768 FBgn0117991 FBgn0116776 FBgn0101711 CPIJ000872 BGIBMGA004196 ACYPI008886 ACYPI006422 GB19273 AGAP008838 AAEL011989 PHUM378960 GLEAN_09780
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	24475 w*; P{UAS-Spp.RNAi}3 P{UAS-Spp.RNAi}12/CyO, P{Wee-P.ph0}2 24165 w*; Spp6 cn1 bw1/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7 24166 w*; Spp5 cn1 bw1/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7
VDRC	v7247 w1118; P{GD786}v7247/TM3
Genomic Clones ( 1 )
	BACR48E08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 77 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD07518
Other clones	DPiM_SD07518
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09176 LD08101 LD08288 LD08462 LD10933 LD17047 LD20733 LD22552 LD33708 LD36423 LP03480 LP24213 RE16220 RE16827 RE18476 RE23562 RE23818 RE27568 RE30404 RE31393 RE31544 RE34059 RE34209 RE34520 RE34589 RE42681 RE45780 RE46116 RE49305 RE51205 RE51604 RE58434 RE63150 RE73730 SD02702 SD02703 SD04912 SD07165 SD08321 SD09633 SD12065 SD12128 SD14487 SD15567 SD15620 SD15643 SD16357 SD16385 SD20358 SD21288 SD21757 SD22123
Other clones	bs28g07 CK00414 Dmel_neb_014933_0149_1870 EC38518 EK090040 EK157759 EK172827 EN02331 EN09025 EN13011 EN13153 EN13349 IP03630 IP03730 LD34288 LD34491 RE45781 RP001017362 RP001041013 RP001042274 RP001042903 RP001046192 RP001052680
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031260 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33227
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Spp shanti (Kornberg et al., 2005.1.24)
Source for database merge of
Additional comments
Other Comments
	Spp is required for normal tracheal development. (Casso and Kornberg, 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078720 RefSeq (Proteins) • NP_523444 DDBJ / EMBL / GenBank • AAF51486 AAL48184 AI259950 AI534608 AW944507 AY070713 BE662194 Entrez Gene - A searchable database of RefSeq genes. • 33227 UniProtKB/TrEMBL • Q9VPQ7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase A22, presenilin signal peptide (IPR006639) Peptidase A22B, signal peptide peptidase (IPR007369)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031260 DroID - A comprehensive database of gene and protein interactions. • FBgn0031260 DRSC - Results from RNAi screens. • FBgn0031260 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031260 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11840-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031260 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33227 InParanoid A subset of ortholog calls from InParanoid. • AAEL011989-PA Aedes aegypti (mosquito) AGAP008838-PA Anopheles gambiae (mosquito) XP_393360.2 Apis mellifera (honey bee) XP_001952644.1 Acyrthosiphon pisum (pea aphid) At2g03120.1 Arabidopsis thaliana (wall cress) 33932 Batrachochytrium dendrobatidis (chytrid fungus) 87838 Branchiostoma floridae (lancelet) BGIBMGA004196-PA Bombyx mori (silk worm) ENSBTAP00000011640 Bos taurus (bovine) CN04183 Caenorhabditis brenneri (small nematode) CBP07212 Caenorhabditis briggsae (nematode) CE06364 Caenorhabditis elegans (worm) ENSCAFP00000010466 Canis familiaris (dog) CAGL0K08492g Candida glabrata (haploid yeast) Chro.60109 Cryptosporidium hominis (obligate parasite) ENSCINP00000019835 Ciona intestinalis (sea squirt) JA02708 Caenorhabditis japonica (nematode) CMH005C Cyanidioschyzon merolae (red alga) cn12067 Cryptococcus neoformans (yeast-like fungus) cgd6_840 Cryptosporidium parvum (protozoan parasite) CPIJ000872 Culex pipens (mosquito) ENSCPOP00000010501 Cavia porcellus (guinea pig) 99652 Chlamidomonas reinhardtii (green alga) RP31350 Caenorhabditis remanei (nematode) ENSCSAVP00000013399 Ciona savignyi (sedentary tunicate) 222251 Capitella spl (polychaete worm) DDB0231493 Dictyostelium discoideum (amoeba) DEHA2E19448g Debaryomyces Hansenii (yeast) 303875 Daphnia pulex (daphnia) ENSDARP00000055141 Danio rerio (zebra fish) ENSECAP00000017038 Equus caballus (horse) XP_654079 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000000668 Gymnopilus aculeatus (mushroom) ENSGALP00000010006 Gallus gallus (chicken) GL50803_8429 Giardia lamblia (flagellated protozoan) 187510 Hypsipyla robusta (cedar shoot borer) ENSP00000381237 Homo sapiens (human) ISCW006186-PA Ixodes scapularis (deer tick) 102125 Lottia gigantea (owl limpet) LmjF29.0910 Leishmania major (virus) ENSMODP00000024323 Monodelphis domestica (gray opossum) ENSMMUP00000006786 Macaca mulatta (rhesus monkey) ENSMUSP00000105451 Mus musculus (house mouse) 228311 Nematostella vectensis (starlet anemone) XP_001600867.1 Nasonia vitripennis (wasp) ENSOANP00000003556 Ornithorynchus anatinus (platypus) ENSORLP00000023111 Oryzias latipes (japanese killifish) LOC_Os02g02530.1 Oryza sativa (asian rice) LOC_Os05g36070.1 Oryza sativa (asian rice) 19016 Ostreococcus tauri (green alga) PF14_0543 Plasmodium falciparum (protozoal parasite) PHUM000983-PA Pediculus humanus (human body louse) PP14514 Pristionchus pacificus (nematode) 124035 Physcomitrella patens (moss) 181086 Physcomitrella patens (moss) ENSPPYP00000012161 Pongo pygmaeus (orangutan) 157626 Phytophthora sojae (root rot pathogen) 706551 Populus trichocarpa (black cottonwood) 833167 Populus trichocarpa (black cottonwood) ENSPTRP00000022897 Pan troglodytes (chimpanzee) PVX_117615 Plasmodium vivax (protozoal parasite) ENSRNOP00000010174 Rattus norvegicus (norway rat) 4881781 Sorghum bicolor (sorghum) YKL100C Saccharomyces cerevisiae (budding yeast) SPAC25B8.17 Schizosaccharomyces pombe (fission yeast) 58104 Trichoplax adhaerens (metazoa) XP_967836.1 Tribolium castaneum (red flour beetle) Tc00.1047053507951.260 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000008563 Tetraodon nigroviridis (green spotted pufferfish) 15950 Thalassiosira pseudonana (marine diatom) ENSTRUP00000015369 Takifugu rubripes (pufferfish Takifugu) 145.m00084 Tetrahymena thermophila (ciliate protozoa) 82736.m00170 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000051796 Xenopus tropicalis (frog) YALI0C04818g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33227 modMine - Data generated by the modENCODE project. • FBgn0031260 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16174 NV18122 LH20947 ISCW006186 FBgn0233612 FBgn0216670 FBgn0206850 FBgn0194346 FBgn0171574 JGI_V11_303875 FBgn0071281 FBgn0156856 FBgn0140768 FBgn0117991 FBgn0116776 FBgn0101711 CPIJ000872 BGIBMGA004196 ACYPI008886 ACYPI006422 GB19273 AGAP008838 AAEL011989 PHUM378960 GLEAN_09780
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG11840 (Kim et al., 2004, Keleman et al., 2009.8.5) spp (Casso and Kornberg, 2005, Kilic et al., 2010) Spp (Junell et al., 2007, Geng and MacDonald, 2007, Miller et al., 2010) SPP (Narayanan et al., 2007)
Name Synonym	shanti (Weihofen, 2002.7.28, Greil et al., 2003, Apionishev et al., 2001, ) signal peptide peptidase (Kilic et al., 2010) Signal peptide protease (Kornberg et al., 2005.1.24, Casso and Kornberg, 2005, )
Secondary FlyBase IDs
References ( 26 )
Generate a list of	All references relating to this gene ( 26 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 2 ) Computer file  ( 1 )
Recent research papers ( 5 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Dottorini et al., 2011, BMC Bioinformatics 12: 34 Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. [FBrf0214379] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Kilic et al., 2010, Europ. J. Cell Biol. 89(6): 449--461 The Drosophila Crumbs signal peptide is unusually long and is a substrate for signal peptide peptidase. [FBrf0210611] Miller et al., 2010, Neuron 67(2): 199--212 Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease. [FBrf0211410] Show all research papers ...