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Gene Dmel\Ipk2

General Information
Symbol	Dmel\Ipk2	Species	D. melanogaster
Name	Ipk2	Annotation symbol	CG13688
Feature type	protein_coding_gene	FlyBase ID	FBgn0031267
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	21E2-21E2	Sequence location	2L:573,033..574,264 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ipk2 is referred to in FlyBase by the symbol Dmel\Ipk2 (CG13688, FBgn0031267). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: inositol-1,4,5-trisphosphate 6-kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; inositol tetrakisphosphate 5-kinase activity. There is experimental evidence that it is involved in the biological process: inositol phosphate biosynthetic process; positive regulation of JAK-STAT cascade. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Inositol polyphosphate kinase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1628514_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ipk2. Gene sequence location is 2L:573033..574264.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21E2-21E2   Limits computationally determined from genome sequence between P{lacW}l(2)k09610k09610&P{lacW}Sk09538a and P{PZ}l(2)1068510685&P{lacW}Tango14k00619
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ipk2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Gene model reviewed during 5.42
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ipk2-RA FBtr0078074  NM_134691   1232   309
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ipk2-PA   FBpp0077734   35.3   309   8.06     NP_608535   AAF51477
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Inositol polyphosphate kinase (IPR005522)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51477   AY119207 AAM51067   BG636905   BI637193   BT044231   CO271658   CO309251   CO335629   EC083011   EC215166   EC228859   EC246086   EC259866   EC267722   EL871127   EL871128   ES693156   EV595799
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VPR6 Q8MRX9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
epitope tag Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   salivary gland   • nucleoplasm (Seeds et al., 2004)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleoplasm inferred from direct assay (Seeds et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    175.575 Larval Midgut    107.3 Larval Hindgut    206.5 Larval Malpighian Tubules    244.9 Larval Fat Body    102.6 Larval Salivary Gland    133.7 Larval Trachea    235.475 Larval Carcass    267.8 Adult Head    74.7 Adult Eye    84.45 Adult Brain    66.6 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    147.5 Adult Midgut    260.5 Adult Hindgut    161.6 Adult Malpighian Tubules    294.3 Adult Fat Body    44.7 Adult Salivary Gland    83.3 Adult Heart    77.575 Adult VirginFemale Spermatheca    70.7 Adult InseminatedFemale Spermatheca    74.7 Adult Ovary    418.8 Adult Testis    31.1 Adult Male Accessory Gland    75.3 Adult Carcass    76.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    175.575 Larval Midgut    107.3 Larval Hindgut    206.5 Larval Malpighian Tubules    244.9 Larval Fat Body    102.6 Larval Salivary Gland    133.7 Larval Trachea    235.475 Larval Carcass    267.8 Adult Head    74.7 Adult Eye    84.45 Adult Brain    66.6 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    147.5 Adult Midgut    260.5 Adult Hindgut    161.6 Adult Malpighian Tubules    294.3 Adult Fat Body    44.7 Adult Salivary Gland    83.3 Adult Heart    77.575 Adult VirginFemale Spermatheca    70.7 Adult InseminatedFemale Spermatheca    74.7 Adult Ovary    418.8 Adult Testis    31.1 Adult Male Accessory Gland    75.3 Adult Carcass    76.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    175.575 Larval Midgut    107.3 Larval Hindgut    206.5 Larval Malpighian Tubules    244.9 Larval Fat Body    102.6 Larval Salivary Gland    133.7 Larval Trachea    235.475 Larval Carcass    267.8 Adult Head    74.7 Adult Eye    84.45 Adult Brain    66.6 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    147.5 Adult Midgut    260.5 Adult Hindgut    161.6 Adult Malpighian Tubules    294.3 Adult Fat Body    44.7 Adult Salivary Gland    83.3 Adult Heart    77.575 Adult VirginFemale Spermatheca    70.7 Adult InseminatedFemale Spermatheca    74.7 Adult Ovary    418.8 Adult Testis    31.1 Adult Male Accessory Gland    75.3 Adult Carcass    76.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    175.575 Larval Midgut    107.3 Larval Hindgut    206.5 Larval Malpighian Tubules    244.9 Larval Fat Body    102.6 Larval Salivary Gland    133.7 Larval Trachea    235.475 Larval Carcass    267.8 Adult Head    74.7 Adult Eye    84.45 Adult Brain    66.6 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    147.5 Adult Midgut    260.5 Adult Hindgut    161.6 Adult Malpighian Tubules    294.3 Adult Fat Body    44.7 Adult Salivary Gland    83.3 Adult Heart    77.575 Adult VirginFemale Spermatheca    70.7 Adult InseminatedFemale Spermatheca    74.7 Adult Ovary    418.8 Adult Testis    31.1 Adult Male Accessory Gland    75.3 Adult Carcass    76.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    175.575 Larval Midgut    107.3 Larval Hindgut    206.5 Larval Malpighian Tubules    244.9 Larval Fat Body    102.6 Larval Salivary Gland    133.7 Larval Trachea    235.475 Larval Carcass    267.8 Adult Head    74.7 Adult Eye    84.45 Adult Brain    66.6 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    147.5 Adult Midgut    260.5 Adult Hindgut    161.6 Adult Malpighian Tubules    294.3 Adult Fat Body    44.7 Adult Salivary Gland    83.3 Adult Heart    77.575 Adult VirginFemale Spermatheca    70.7 Adult InseminatedFemale Spermatheca    74.7 Adult Ovary    418.8 Adult Testis    31.1 Adult Male Accessory Gland    75.3 Adult Carcass    76.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    175.575 Larval Midgut    107.3 Larval Hindgut    206.5 Larval Malpighian Tubules    244.9 Larval Fat Body    102.6 Larval Salivary Gland    133.7 Larval Trachea    235.475 Larval Carcass    267.8 Adult Head    74.7 Adult Eye    84.45 Adult Brain    66.6 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    147.5 Adult Midgut    260.5 Adult Hindgut    161.6 Adult Malpighian Tubules    294.3 Adult Fat Body    44.7 Adult Salivary Gland    83.3 Adult Heart    77.575 Adult VirginFemale Spermatheca    70.7 Adult InseminatedFemale Spermatheca    74.7 Adult Ovary    418.8 Adult Testis    31.1 Adult Male Accessory Gland    75.3 Adult Carcass    76.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    175.575 Larval Midgut    107.3 Larval Hindgut    206.5 Larval Malpighian Tubules    244.9 Larval Fat Body    102.6 Larval Salivary Gland    133.7 Larval Trachea    235.475 Larval Carcass    267.8 Adult Head    74.7 Adult Eye    84.45 Adult Brain    66.6 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    147.5 Adult Midgut    260.5 Adult Hindgut    161.6 Adult Malpighian Tubules    294.3 Adult Fat Body    44.7 Adult Salivary Gland    83.3 Adult Heart    77.575 Adult VirginFemale Spermatheca    70.7 Adult InseminatedFemale Spermatheca    74.7 Adult Ovary    418.8 Adult Testis    31.1 Adult Male Accessory Gland    75.3 Adult Carcass    76.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    175.575 Larval Midgut    107.3 Larval Hindgut    206.5 Larval Malpighian Tubules    244.9 Larval Fat Body    102.6 Larval Salivary Gland    133.7 Larval Trachea    235.475 Larval Carcass    267.8 Adult Head    74.7 Adult Eye    84.45 Adult Brain    66.6 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    147.5 Adult Midgut    260.5 Adult Hindgut    161.6 Adult Malpighian Tubules    294.3 Adult Fat Body    44.7 Adult Salivary Gland    83.3 Adult Heart    77.575 Adult VirginFemale Spermatheca    70.7 Adult InseminatedFemale Spermatheca    74.7 Adult Ovary    418.8 Adult Testis    31.1 Adult Male Accessory Gland    75.3 Adult Carcass    76.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    74.7   NA  Eye    84.45   NA  Brain    66.6   175.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    59.7   NA  Crop    147.5   107.3  Midgut    260.5   206.5  Hindgut    161.6   244.9  Malpighian Tubules    294.3   102.6  Fat Body    44.7   133.7  Salivary Gland    83.3   NA  Heart    77.575   235.475  Trachea    NA   NA  VirginFemale Spermatheca    70.7   NA  InseminatedFemale Spermatheca    74.7   NA  Ovary    418.8   NA  Testis    31.1   NA  Male Accessory Gland    75.3   267.8  Carcass    76.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    30 digestive system, 4-day adult    19 digestive system, 20-day adult    23 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    36 carcass, larvae L3 wandering    57 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    68 ovary, mated 4-day female    44 testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult  (30) digestive system, 4-day adult    19 digestive system, 20-day adult    23 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8  (36) carcass, larvae L3 wandering  (57) carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female  (68) ovary, mated 4-day female  (44) testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    30 digestive system, 4-day adult    19 digestive system, 20-day adult    23 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    36 carcass, larvae L3 wandering    57 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    68 ovary, mated 4-day female    44 testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    30 digestive system, 4-day adult    19 digestive system, 20-day adult    23 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    36 carcass, larvae L3 wandering    57 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    68 ovary, mated 4-day female    44 testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    30 digestive system, 4-day adult    19 digestive system, 20-day adult    23 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    36 carcass, larvae L3 wandering    57 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    68 ovary, mated 4-day female    44 testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult  30 digestive system, 4-day adult    19 digestive system, 20-day adult    23 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8  (36) carcass, larvae L3 wandering  (57) carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female  (68) ovary, mated 4-day female  (44) testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    30 digestive system, 4-day adult    19 digestive system, 20-day adult    23 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    36 carcass, larvae L3 wandering    57 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    68 ovary, mated 4-day female    44 testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    30 digestive system, 4-day adult    19 digestive system, 20-day adult    23 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    36 carcass, larvae L3 wandering    57 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    68 ovary, mated 4-day female    44 testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    5 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    8 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    42 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    16 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    15 adult female 05day    35 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (51) embryo 02-04hr    5 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    8 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9  (42) white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    16 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    15 adult female 05day  (35) adult female 30day  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    5 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    8 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    42 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    16 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    15 adult female 05day    35 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    5 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    8 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    42 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    16 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    15 adult female 05day    35 adult female 30day    36 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    5 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    8 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    42 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    16 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    15 adult female 05day    35 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (51) embryo 02-04hr    5 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    8 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9  (42) white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    16 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    15 adult female 05day  (35) adult female 30day  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    5 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    8 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    42 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    16 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    15 adult female 05day    35 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    5 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    7 embryo 10-12hr    6 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    7 larva L1    8 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    42 white prepupae new    19 white prepupae 12hr    19 white prepupae 24hr    16 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    15 adult female 05day    35 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    39 embryonic 1182-4H    37 embryonic GM2    51 embryonic Kc167    131 embryonic S1    28 embryonic S3    24 leg disc CME L1    30 wing disc CME-W2    44 wing disc ML-DmD8    27 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    45 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    86 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    60 ovary fGS/OSS    37 ovary OSC    32 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (44) Schneider line 2 Sg4  (39) embryonic 1182-4H  (37) embryonic GM2  (51) embryonic Kc167  (131) embryonic S1  (28) embryonic S3    24 leg disc CME L1  (30) wing disc CME-W2  (44) wing disc ML-DmD8  (27) wing disc ML-DmD9  (33) wing disc ML-DmD16-c3  (33) wing disc ML-DmD21  (45) wing disc ML-DmD32    21 haltere disc ML-DmD17-c3  (69) eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5  (86) mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1  (31) CNS ML-DmBG2-c2  (38) tumorous blood cells mbn2  (60) ovary fGS/OSS  (37) ovary OSC  (32) ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    39 embryonic 1182-4H    37 embryonic GM2    51 embryonic Kc167  (131) embryonic S1    28 embryonic S3    24 leg disc CME L1    30 wing disc CME-W2    44 wing disc ML-DmD8    27 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    45 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    86 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    60 ovary fGS/OSS    37 ovary OSC    32 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    39 embryonic 1182-4H    37 embryonic GM2    51 embryonic Kc167    131 embryonic S1    28 embryonic S3    24 leg disc CME L1    30 wing disc CME-W2    44 wing disc ML-DmD8    27 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    45 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    86 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    60 ovary fGS/OSS    37 ovary OSC    32 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    39 embryonic 1182-4H    37 embryonic GM2    51 embryonic Kc167    131 embryonic S1    28 embryonic S3    24 leg disc CME L1    30 wing disc CME-W2    44 wing disc ML-DmD8    27 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    45 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    86 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    60 ovary fGS/OSS    37 ovary OSC    32 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (44) Schneider line 2 Sg4  (39) embryonic 1182-4H  (37) embryonic GM2  (51) embryonic Kc167  (131) embryonic S1  28 embryonic S3    24 leg disc CME L1  30 wing disc CME-W2  (44) wing disc ML-DmD8  27 wing disc ML-DmD9  (33) wing disc ML-DmD16-c3  (33) wing disc ML-DmD21  (45) wing disc ML-DmD32    21 haltere disc ML-DmD17-c3  (69) eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5  (86) mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1  31 CNS ML-DmBG2-c2  (38) tumorous blood cells mbn2  (60) ovary fGS/OSS  (37) ovary OSC  32 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    39 embryonic 1182-4H    37 embryonic GM2    51 embryonic Kc167  131 embryonic S1    28 embryonic S3    24 leg disc CME L1    30 wing disc CME-W2    44 wing disc ML-DmD8    27 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    45 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    86 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    60 ovary fGS/OSS    37 ovary OSC    32 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    39 embryonic 1182-4H    37 embryonic GM2    51 embryonic Kc167    131 embryonic S1    28 embryonic S3    24 leg disc CME L1    30 wing disc CME-W2    44 wing disc ML-DmD8    27 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    45 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    86 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    60 ovary fGS/OSS    37 ovary OSC    32 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    38 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    62 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3  (38) Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (62) Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult  (33) Ethanol 2.5% 3 hrs, larvae L3  (33) Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult  (30) Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    38 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    62 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    38 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    62 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    38 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    62 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3  (38) Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (62) Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult  (33) Ethanol 2.5% 3 hrs, larvae L3  (33) Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult  30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    38 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    62 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    38 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    62 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031267 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13688-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Ipk2GD8093 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Ipk2 Class Mutagen Stocks Known lesion Ipk2G3545 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ipk2 Class Mutagen Stocks Known lesion Ipk2GD8093 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ipk2GL00143 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ipk2dsRNA.cSa in vitro construct - RNAi 0 Yes Ipk2dsRNA.Scer\UAS.WIZ in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ipk2NIG.13688R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ipk2Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC16 (Seeds et al., 2004) Df(2L)Exel8003 (Ryder, 2004.4.26) Df(2L)NleΔ8 (Seeds et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8093} NA P{NIG.13688R} NA P{TRiP.GL00143} NA P{UAS-Ipk2.dsRNA.WIZ} NA P{UAS-Ipk2.FLAG} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Ipk2G3545 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
inositol-1,4,5-trisphosphate 3-kinase activity inferred from direct assay (Seeds et al., 2004) inositol-1,4,5-trisphosphate 6-kinase activity inferred from direct assay (Seeds et al., 2004) inositol tetrakisphosphate 5-kinase activity inferred from direct assay (Seeds et al., 2004)
Biological Process
CV term Evidence References
inositol phosphate biosynthetic process inferred from direct assay (Seeds et al., 2004) positive regulation of JAK-STAT cascade inferred from mutant phenotype (Muller et al., 2005)
Cellular Component
CV term Evidence References
nucleoplasm inferred from direct assay (Seeds et al., 2004)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ipk2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59492 DroID - A comprehensive database of gene and protein interactions. • FBgn0031267 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33236
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63BN81 Dipteran inclusive ortholog search EOG68SH2T Insect inclusive ortholog search EOG6J9KVZ Arthropod inclusive ortholog search EOG67PVNZ Metazoa inclusive ortholog search EOG6PZX22
Orthologs in Drosophila Species (EOG63BN81)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ipk2     Drosophila simulans   Dsim\GD22857 Y   Drosophila sechellia   Dsec\GM16655 Y   Drosophila erecta   Dere\GG24638 Y   Drosophila yakuba   Dyak\GE16007 Y   Drosophila ananassae   Dana\GF14878 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12460 Y   Drosophila persimilis   Dper\GL19251 Y   Drosophila willistoni   Dwil\GK24631 Y   Drosophila virilis   Dvir\GJ19687 Y   Drosophila mojavensis   Dmoj\GI18022 Y   Drosophila grimshawi   Dgri\GH10503 Y
Orthologs in non-Drosophila Dipterans (EOG68SH2T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002846   Anopheles gambiae Malaria mosquito  Agam\AGAP012098   Anopheles gambiae Malaria mosquito  Agam\AGAP012099   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006477   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016779
Orthologs in non-Dipteran Insects (EOG6J9KVZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Ipk2   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008227   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26426   Atta cephalotes Leafcutter ant  Acep\ACEP18162   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15586   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23454   Linepithema humile Argentine ant  Lhum\LH17247   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11093   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007085   Bombyx mori Silkmoth  Bmor\BGIBMGA007362   Pediculus humanus Human body louse  Phum\PHUM268930   Tribolium castaneum Red flour beetle  Tcas\TC005770
Orthologs in non-Insect Arthropods (EOG67PVNZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rpl16   Ixodes scapularis Deer tick  Isca\ISCW017482
Orthologs in non-Arthropod Metazoa (EOG6PZX22)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ZK795.1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020707gn   Danio rerio Zebrafish  Drer\ipmkb   Danio rerio Zebrafish  Drer\ipmka   Xenopus tropicalis Western clawed frog  Xtro\ipmk   Gallus gallus Domestic chicken  Ggal\IPMK   Rattus norvegicus Norway rat  Rnor\Ipmk   Homo sapiens Human  Hsap\IPMK
Human Orthologs (1)
Gene OMIM HGNC Hsap\IPMK
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22857 Drosophila sechellia Dsec\GM16655 Drosophila erecta Dere\GG24638 Drosophila yakuba Dyak\GE16007 Drosophila ananassae Dana\GF14878 Drosophila pseudoobscura pseudoobscura Dpse\GA12460 Drosophila persimilis Dper\GL19251 Drosophila willistoni Dwil\GK24631 Drosophila virilis Dvir\GJ19687 Drosophila mojavensis Dmoj\GI18022 Drosophila grimshawi Dgri\GH10503
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	33474 w1118; P{EP}Ipk2G3545 35255 y1 sc* v1; P{TRiP.GL00143}attP2
VDRC	v43824 w1118; P{GD8093}v43824/TM3 v43825 w1118; P{GD8093}v43825/CyO
Genomic Clones ( 1 )
	BACR48E08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 8 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD14726
Other clones	FI05605
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	SD19137
Other clones	Dmel_neb_013828_0635_1731 EK104154 EK260833 EN10852 IP03273
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031267 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33236
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ipk2 CG13688 (Seeds et al., 2004)
Source for database merge of
Additional comments	FlyBase curator comment: the insertion in the "f05607" Exelixis line (PBac{WH}CG2813f05607) was originally assigned to the Ipk2 gene in FBrf0179797, resulting in the "Ipk2f05607" (FBal0160279) allele. However, FBrf0184340 shows that the insertion is actually within CG2813. (Bloomington Drosophila Stock Center, 2004.11.6)
Other Comments
	The Ipk2 enzyme is a 6-/3-kinase that converts inositol 1,4,5-trisphosphate to inositol 1,3,4,5,6-pentakisphosphate and this is likely to be a processive reaction where the majority of the inositol 1,4,5,6-tetrakisphosphate intermediate is phosphorylated rather than released. In addition, the Ipk2 enzyme harbours 5-kinase activity towards inositol 1,3,4,6-tetrakisphosphate. (Seeds et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134691 RefSeq (Proteins) • NP_608535 DDBJ / EMBL / GenBank • AAF51477 AAM51067 AY119207 BG636905 Entrez Gene - A searchable database of RefSeq genes. • 33236 UniProtKB/TrEMBL • Q8MRX9 Q9VPR6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Inositol polyphosphate kinase (IPR005522)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59492 DroID - A comprehensive database of gene and protein interactions. • FBgn0031267 DRSC - Results from RNAi screens. • FBgn0031267 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031267 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13688-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031267 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33236 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33236 modMine - Data generated by the modENCODE project. • FBgn0031267
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG13688 (Seeds et al., 2004, Li et al., 2009, Ni et al., 2011.7.19) dmIpk2 (Seeds et al., 2004) Ipk2 (Tsui et al., 2008, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Ipk2
Secondary FlyBase IDs
References ( 18 )
Research paper	Li et al., 2009, Insect Mol. Biol. 18(1): 21--31 Transcriptional signatures in response to wheat germ agglutinin and starvation in Drosophila melanogaster larval midgut. [FBrf0206697] Muller et al., 2005, Nature 436(7052): 871--875 Identification of JAK/STAT signalling components by genome-wide RNA interference. [FBrf0188561] Seeds et al., 2004, J. Biol. Chem. 279(45): 47222--47232 A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. [FBrf0179834]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2011.7.19, TRiP germline vector pVALIUM21. TRiP germline vector pVALIUM21. [FBrf0214641] Bellen, 2010.12.8, BDGP_2010_1209.GenExel.xml BDGP_2010_1209.GenExel.xml [FBrf0212439] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
Abstract	Tsui et al., 2008, A. Dros. Res. Conf. 49: 354C A Role for Ipk2 Kinase Activity in Regulating Cell Proliferation and Apoptosis of Imaginal Disc Tissue During Drosophila Melanogaster Development. [FBrf0203988]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Curated genome annotation	Zhu, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126704]