FlyBase Gene Report: Dmel\GABA-B-R3

General Information

Symbol

Dmel\GABA-B-R3

Species

D. melanogaster

Name

metabotropic GABA-B receptor subtype 3

Annotation Symbol

CG3022

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031275

Gene Model Status

Current

Stock Availability

51 publicly available

Gene Summary

metabotropic GABA-B receptor subtype 3 (GABA-B-R3) encodes a G-protein coupled receptor for the GABA neurotransmitter that is coupled to the Go G protein and activation of phospholipase C. Activation of the product of GABA-B-R3 can inhibit neuronal activity. It functions in the olfactory system and in the regulation of sleep and circadian rhythms. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

GABA_BR3, GABA_B-R3

Key Links

Genomic Location

Cytogenetic map

21E2-21E2

Sequence location

2L:749,945..762,399 [+]

Recombination map

2-1.5

RefSeq locus

NT_033779 REGION:749945..762399

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables G protein-coupled GABA receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000054983

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002455

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR017978

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR000337, InterPro:IPR017978

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in sleep

inferred from mutant phenotype

(Haynes et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from electronic annotation with InterPro:IPR002455

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR002455, InterPro:IPR017978

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR000337, InterPro:IPR002455, InterPro:IPR017978

(InterPro Project Members, 2004-)

involved_in gamma-aminobutyric acid signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000054983

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of G protein-coupled receptor heterodimeric complex

inferred from biological aspect of ancestor with PANTHER:PTN000828857

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR002455

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR002455, InterPro:IPR017978

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR000337, InterPro:IPR002455, InterPro:IPR017978

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

Gene Group (FlyBase)

GABA(B) RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

GABA(B) RECEPTORS -: Metabotropic GABA(B) receptors are Class C GPCRs. They function as obligate heterodimers, binding the inhibitory neurotransmitter GABA (γ-aminobutyric acid). (Adapted from FBrf0134605).

Summary (Interactive Fly)

G-protein coupled receptor - expressed by pheromone-sensing olfactory receptor neurons which as a consequence exhibit strong presynaptic inhibition - mediates inter-glomerular inhibition - responsible for decreased intracellular calcium of clock neurons blocking their calcium cycling

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\GABA-B-R3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VPS7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

5GWM

Comments on Gene Model

Gene model reviewed during 5.52

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

GABA-B-R3-RA

FBtr0078001

NM_078723

5466

1305

GABA-B-R3-RC

FBtr0301439

NM_001169375

2359

650

GABA-B-R3-RD

FBtr0308257

NM_001258897

5730

1305

GABA-B-R3-RE

FBtr0343785

NM_164387

5991

1305

GABA-B-R3-RF

FBtr0343786

NM_001298624

5633

357

GABA-B-R3-RG

FBtr0343787

NM_001298625

5987

1305

GABA-B-R3-RH

FBtr0346526

NM_001298623

5800

450

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

GABA-B-R3-PA

FBpp0077666

143.6

1305

9.73

FBpp0290654

72.0

650

9.80

FBpp0300577

143.6

1305

9.73

FBpp0310350

143.6

1305

9.73

FBpp0310351

39.1

357

9.83

FBpp0310352

143.6

1305

9.73

FBpp0312144

49.6

450

8.87

X2J962

NP_001285552

AHN54067

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1305 aa isoforms: GABA-B-R3-PA, GABA-B-R3-PD, GABA-B-R3-PE, GABA-B-R3-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

5GWM

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GABA-B-R3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.51

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

larval gnathal ganglion | segmentally repeated

(Mezler et al., 2001)

larval brain | segmentally repeated

(Mezler et al., 2001)

larval ventral nerve cord | segmentally repeated

(Mezler et al., 2001)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\GABA-B-R3 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\GABA-B-R3

View exonic expression by tissue for Dmel\GABA-B-R3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031275

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33248/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031275

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031275

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031275

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3022

Flygut - An atlas of the Drosophila adult midgut

FBgn0031275

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of GABA-B-R3

Transgenic constructs containing regulatory region of GABA-B-R3

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel6002

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Other Phenotypes

Allele

abnormal circadian rhythm, with Scer\GAL4^P0.5.Pdf

GABA-B-R3^GD578

abnormal sleep, with Scer\GAL4^c305a

GABA-B-R3^GD578

abnormal sleep | adult stage

GABA-B-R3^attP

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (22)

Hsap\GABBR2

4 of 14

Yes

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\TAS1R2

1 of 14

Yes

Hsap\TAS1R3

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (37)

Rnor\Gabbr2

4 of 14

Yes

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Tas1r2

1 of 14

Yes

Rnor\Vom2r1

1 of 14

Yes

Rnor\Vom2r4

1 of 14

Yes

Rnor\Vom2r5

1 of 14

Yes

Rnor\Vom2r6

1 of 14

Yes

Rnor\Vom2r10

1 of 14

Yes

Rnor\Vom2r11

1 of 14

Yes

Rnor\Vom2r18

1 of 14

Yes

Rnor\Vom2r37

1 of 14

Yes

Rnor\Vom2r44

1 of 14

Yes

Rnor\Vom2r47

1 of 14

Yes

Rnor\Vom2r53

1 of 14

Yes

Rnor\Vom2r54

1 of 14

Yes

Rnor\Vom2r67

1 of 14

Yes

Rnor\Vom2r68

1 of 14

Yes

Rnor\Vom2r70

1 of 14

Yes

Rnor\Vom2r79

1 of 14

Yes

Rnor\Vom2r80

1 of 14

Yes

Rnor\Vom2r-ps27

1 of 14

Yes

Mus musculus (laboratory mouse) (56)

Mmus\Gabbr1

3 of 14

Yes

Mmus\Gabbr2

3 of 14

Yes

Mmus\Gpr156

2 of 14

Mmus\Gm14496

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Vmn2r2

1 of 14

Yes

Mmus\Vmn2r4

1 of 14

Yes

Mmus\Vmn2r5

1 of 14

Yes

Mmus\Vmn2r6

1 of 14

Yes

Mmus\Vmn2r7

1 of 14

Yes

Mmus\Vmn2r9

1 of 14

Yes

Mmus\Vmn2r10

1 of 14

Yes

Mmus\Vmn2r11

1 of 14

Yes

Mmus\Vmn2r14

1 of 14

Yes

Mmus\Vmn2r15

1 of 14

Yes

Mmus\Vmn2r61

1 of 14

Yes

Mmus\Vmn2r80

1 of 14

Yes

Mmus\Vmn2r81

1 of 14

Yes

Mmus\Vmn2r82

1 of 14

Yes

Mmus\Vmn2r84

1 of 14

Yes

Mmus\Vmn2r85

1 of 14

Yes

Mmus\Vmn2r86

1 of 14

Yes

Mmus\Vmn2r87

1 of 14

Yes

Mmus\Vmn2r90

1 of 14

Yes

Mmus\Vmn2r91

1 of 14

Yes

Mmus\Vmn2r92

1 of 14

Yes

Mmus\Vmn2r93

1 of 14

Yes

Mmus\Vmn2r94

1 of 14

Yes

Mmus\Vmn2r95

1 of 14

Yes

Mmus\Vmn2r96

1 of 14

Yes

Mmus\Vmn2r100

1 of 14

Yes

Mmus\Vmn2r101

1 of 14

Yes

Mmus\Vmn2r102

1 of 14

Yes

Mmus\Vmn2r104

1 of 14

Yes

Mmus\Vmn2r107

1 of 14

Yes

Mmus\Vmn2r112

1 of 14

Yes

Mmus\Vmn2r113

1 of 14

Yes

Mmus\Vmn2r115

1 of 14

Yes

Mmus\Vmn2r116

1 of 14

Yes

Mmus\Vmn2r117

1 of 14

Yes

Mmus\Vmn2r129

1 of 14

Yes

Mmus\Vmn2r130

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (33)

Xtro\gabbr2

3 of 13

Yes

Xtro\gabbr1

2 of 13

Xtro\c11orf49

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100490381

1 of 13

Yes

Xtro\LOC100490505

1 of 13

Yes

Xtro\LOC100491800

1 of 13

Yes

Xtro\LOC100493136

1 of 13

Yes

Xtro\LOC100494461

1 of 13

Yes

Xtro\LOC100496766

1 of 13

Yes

Xtro\LOC100496848

1 of 13

Yes

Xtro\LOC100498444

1 of 13

Yes

Xtro\LOC101733546

1 of 13

Yes

Xtro\LOC101734131

1 of 13

Yes

Xtro\LOC105946413

1 of 13

Xtro\LOC108646252

1 of 13

Yes

Xtro\LOC108648105

1 of 13

Yes

Xtro\LOC116409579

1 of 13

Yes

Xtro\npr3

1 of 13

Xtro\rtp3

1 of 13

Yes

Xtro\stam2

1 of 13

Xtro\steap2

1 of 13

Xtro\vn2r1p

1 of 13

Yes

Xtro\XB991396

1 of 13

Yes

Danio rerio (Zebrafish) (55)

Drer\gabbr2

4 of 14

Yes

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100007225

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\olfcd2

1 of 14

Yes

Drer\olfcd3

1 of 14

Yes

Drer\olfce2

1 of 14

Yes

Drer\olfcg1

1 of 14

Yes

Drer\olfcg2

1 of 14

Yes

Drer\olfcg3

1 of 14

Yes

Drer\olfcg4

1 of 14

Yes

Drer\olfcg5

1 of 14

Yes

Drer\olfcg6

1 of 14

Yes

Drer\olfcg7

1 of 14

Yes

Drer\olfcg8

1 of 14

Yes

Drer\olfcg9

1 of 14

Yes

Drer\olfcg12

1 of 14

Yes

Drer\olfch1

1 of 14

Yes

Drer\olfcj1

1 of 14

Yes

Drer\olfck1

1 of 14

Yes

Drer\olfck2

1 of 14

Yes

Drer\olfcn1

1 of 14

Yes

Drer\olfcq12

1 of 14

Yes

Drer\olfcu1

1 of 14

Yes

Drer\olfcv1

1 of 14

Yes

Drer\olfcv2

1 of 14

Yes

Drer\olfcv3

1 of 14

Yes

Drer\olfcw1

1 of 14

Yes

Drer\si:dkey-37g12.1

1 of 14

Drer\tas1r1

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\gbb-2

4 of 14

Yes

Cele\gbb-1

2 of 14

Cele\C30A5.10

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\GPRGBB3

12 of 12

Yes

Agam\GPRGBB2

4 of 12

Agam\GPRGBB1

3 of 12

Agam\AgaP_AGAP009158

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (17)

Atha\GLR3.4

2 of 13

Yes

Atha\GLR3.5

2 of 13

Yes

Atha\GLR5

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (1)

Ecol\livK

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:GABA-B-R3. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (12)

6 of 13

5 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

mtt

1 of 13

smog

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

GABBR2; gamma-aminobutyric acid type B receptor subunit 2

model of developmental and epileptic encephalopathy 59

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

GABA-B-R3^KK105961

exacerbates amyotrophic lateral sclerosis type 10

modeled by TBPH^Δ23, TBPH^GD6943

(Romano et al., 2021)

GABA-B-R3^HMC02989

exacerbates amyotrophic lateral sclerosis type 10

modeled by TBPH^Δ23, TBPH^GD6943

(Romano et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GABBR2; gamma-aminobutyric acid type B receptor subunit 2

4 of 14

607340

developmental and epileptic encephalopathy 59

GABBR1; gamma-aminobutyric acid type B receptor subunit 1

3 of 14

603540

NEURODEVELOPMENTAL DISORDER WITH LANGUAGE DELAY AND VARIABLE COGNITIVE ABNORMALITIES; NEDLC

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0031275

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-1.5

Cytogenetic map

21E2-21E2

Sequence location

2L:749,945..762,399 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21E2-21E2

Limits computationally determined from genome sequence between P{lacW}l(2)k09610^k09610&P{lacW}S^k09538a and P{PZ}l(2)10685¹⁰⁶⁸⁵&P{lacW}Tango14^k00619

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-1.5

(FlyBase, 2016)

2-0.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (51)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

39923

w¹¹¹⁸; P{GMR76C01-GAL4}attP2

39924

w¹¹¹⁸; P{GMR76C05-GAL4}attP2

39925

w¹¹¹⁸; P{GMR76C06-GAL4}attP2

39926

w¹¹¹⁸; P{GMR76C07-GAL4}attP2

Korea

13054

P{VT000353-GAL4}attP2

13055

P{VT000355-GAL4}attP2

13056

P{VT000357-GAL4}attP2

16690

P{VT000355-lexA::GADfl}attP40

17475

P{VT000357-lexA::GADfl}attP40

VDRC

v108036

P{KK105961}VIE-260B

v50176

w¹¹¹⁸; P{GD578}v50176/TM3

v318614

PBac{fTRG00613.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (28)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (14)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031275

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031275

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: GABA-B-R3 anon-WO0170980.13 anon-WO0170980.14

(FlyBase, 1996-)

Additional comments

Source for identity of GABA-B-R3 CG3022 was sequence comparison ( date:010307 ).

(FlyBase, 1996-)

Source for merge of GABA-B-R3 anon-WO0170980.13 anon-WO0170980.14 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: GABA-B-R3 CG3022

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG3022

(Mao et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Jayakumar et al., 2016, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Panhuis and Swanson, 2006, Vanden Broeck, 2001)

D-GABA-B-R3

(Khuong et al., 2019)

D-GABA_BR3

(Mezler et al., 2001)

D-Gaba3

(Mezler et al., 2001)

GABA B R3

(Shankar et al., 2015)

GABA-B R3

(Chaturvedi and Emery, 2024)

GABA-BR3

(Dissel et al., 2015)

GABA_B-R3

(Pavlou et al., 2016, Dahdal et al., 2010)

GABA_BR3

(Slankster et al., 2020, Tomita et al., 2017, Jeong et al., 2016, Haynes et al., 2015, Yuan et al., 2014)

GABAB(R3)

(Mazzotta et al., 2020)

GABAb R3

(Golovin et al., 2019)

GB3

(Mitri et al., 2004)

anon-WO0170980.13

anon-WO0170980.14

Name Synonyms

GABA-B receptor subtype 3

(Guan et al., 2011)

metabotropic GABA-B receptor subtype 3

(Mezler, 2000.11.2)

Secondary FlyBase IDs

FBgn0046594
FBgn0046602

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 62 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33248

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VPS7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VPS7

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031275

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33248/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031275

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031275

FlyMine - An integrated database for Drosophila genomics

FBgn0031275

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3022

MARRVEL_MODEL - MARRVEL (model organism gene)

33248

PDB - An information portal to biological macromolecular structures

5GWM

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031275

DroID - A comprehensive database of gene and protein interactions.

FBgn0031275

DRSC - Results frm RNAi screens

FBgn0031275

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031275

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031275

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3022

Flygut - An atlas of the Drosophila adult midgut

FBgn0031275

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007169

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

References (81)

The following external sites may use different assemblies or annotations than FlyBase.

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