FlyBase Gene Report: Dmel\Atg4a

General Information

Symbol

Dmel\Atg4a

Species

D. melanogaster

Name

Autophagy-related 4a

Annotation Symbol

CG4428

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031298

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Snapshot

Autophagy-related 4a (Atg4a) encodes a protein involved in autophagy. [Date last reviewed: 2019-06-27]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Atg4

Key Links

Genomic Location

Cytogenetic map

21E4-21E4

Sequence location

2L:1,080,911..1,085,380 [+]

Recombination map

2-1.5

RefSeq locus

NT_033779 REGION:1080911..1085380

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables Atg8-specific protease activity

inferred from sequence or structural similarity with UniProtKB:P53867

(Thumm and Kadowaki, 2001)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in autophagy

inferred from mutant phenotype

(Xu et al., 2015, Lőw et al., 2013)

NOT involved_in larval midgut cell programmed cell death

inferred from mutant phenotype

(Chang et al., 2013)

involved_in regulation of autophagy

inferred from mutant phenotype

(Pircs et al., 2012)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from sequence or structural similarity with UniProtKB:P53867

(FlyBase Curators, 2008--)

Gene Group (FlyBase)

AUTOPHAGY-RELATED GENES

ATG8 PROTEASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

AUTOPHAGY-RELATED GENES -: The Autophagy-related genes (Atg), characterized extensively in yeast, are a set of approximately twenty evolutionarily conserved genes required for autophagy. Autophagy (specifically, macroautophagy) is the process of bulk degradation of cytoplasmic material. It takes place by the assembly of a double membrane vesicle, the autophagosome, which delivers cargo to the lysosome for recycling. (Adapted from FBrf0219844 and FBrf020902).
ATG8 PROTEASES -: During macroautophagy/autophagy, ATG8-family proteases undergo 2 distinct proteolytic processing events. First, in support of phagophore growth, ATG8 is cleaved by ATG4 to expose a glycine at the COOH-terminus. The exposed glycine is then utilized in a series of ubiquitin-like reactions culminating in the covalent attachment of the ATG8-family protein to the phospholipid phosphatidylethanolamine (PE). Second, following autophagosome maturation, each ATG8 protein is recycled off the membrane by an ATG4-mediated cleavage that breaks the bond between glycine and PE. Thus, ATG4 is responsible for both early and late cleavage events on distinct pools (soluble and lipid-attached) of ATG8-related proteins. ATG8-family proteases are included within MEROPS family C54. (Adapted from PMID:29458288.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Atg4a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Antisense UTR: extended 3' UTR (one isoform) overlaps CDS of CG4629 on the opposite strand.

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Atg4a-RA

FBtr0077953

NM_134719

2076

411

Atg4a-RB

FBtr0332569

NM_001272923

4075

410

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Atg4a-PA

FBpp0077618

45.6

411

4.53

NP_608563

AAF51423

Atg4a-PB

FBpp0304824

45.5

410

4.56

NP_001259852

AGB92389

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atg4a using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Atg4a in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Atg4a

View exonic expression by tissue for Dmel\Atg4a

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031298

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0031298

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4428-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4428

Flygut - An atlas of the Drosophila adult midgut

FBgn0031298

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Atg4a

Transgenic constructs containing regulatory region of Atg4a

Deletions and Duplications ( 2 )

Disrupted in

Df(2L)Exel6004

(Ryder, 2004.4.26)

Df(2L)Exel9037

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Atg4a^GD11315

partially lethal, with Scer\GAL4^tin.CΔ4

Atg4a^GD11315

viable, with Scer\GAL4^pnr-MD237

Atg4a^GD11315

Other Phenotypes

Allele

locomotor behavior defective | adult stage, with Scer\GAL4^Mef2.PU

Atg4a^KK108570

some die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Atg4a^GD11315

starvation stress response defective | larval stage, with Scer\GAL4^Cg.PU

Atg4a^HMS01482

starvation stress response defective | late third instar larval stage | somatic clone, with Scer\GAL4^Act5C.PP

Atg4a^C98A.UAS

Phenotype manifest in

Allele

autophagosome | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PP

Atg4a^C98A.UAS

embryonic/larval fat body | larval stage, with Scer\GAL4^Cg.PU

Atg4a^HMS01482

embryonic/larval fat body | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PP

Atg4a^C98A.UAS

lysosome | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PP

Atg4a^C98A.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ATG4A

14 of 15

Yes

Hsap\ATG4B

13 of 15

Yes

Hsap\ATG4C

5 of 15

Hsap\ATG4D

5 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Atg4a

14 of 15

Yes

Mmus\Atg4b

12 of 15

Yes

Mmus\Atg4c

5 of 15

Mmus\Atg4d

5 of 15

Mmus\Atg4a-ps

1 of 15

Yes

Rattus norvegicus (Norway rat) (5)

Rnor\Atg4b

11 of 13

Yes

Rnor\Atg4a

5 of 13

Yes

Rnor\Atg4c

4 of 13

Rnor\Atg4d

3 of 13

Rnor\LOC108348284

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\atg4b

12 of 12

Yes

Xtro\atg4a

8 of 12

Yes

Xtro\atg4c

4 of 12

Xtro\atg4d

3 of 12

Danio rerio (Zebrafish) (6)

Drer\atg4b

13 of 15

Yes

Drer\atg4a

12 of 15

Yes

5 of 15

5 of 15

3 of 15

2 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\atg-4.1

13 of 15

Yes

Cele\atg-4.2

5 of 15

Arabidopsis thaliana (thale-cress) (3)

Atha\AT3G59950

8 of 9

Yes

Atha\AT2G44140

6 of 9

Yes

Atha\AT2G44130

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\ATG4

12 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\atg4

10 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919090A )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18177

Drosophila persimilis

Dper\GL15485

Drosophila willistoni

Dwil\GK24338

Drosophila virilis

Dvir\GJ16311

Drosophila mojavensis

Dmoj\GI17971

Drosophila grimshawi

Dgri\GH13687

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915061G )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17023304

Glossina morsitans

Tsetse fly

Gmor\GMOY009754

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_14314

Mayetiola destructor

Hessian fly

Mdes\Mdes016462

Aedes aegypti

Yellow fever mosquito

Aaeg\APG4B

Anopheles darlingi

American malaria mosquito

Adar\ADAC001772

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004347

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06TC )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006175

Danaus plexippus

Monarch butterfly

Dple\DPOGS214126-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL011377

Apis florea

Little honeybee

Aflo\4055905844

Apis mellifera

Western honey bee

Amel\Atg4

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP25652

Bombus terrestris

Buff-tailed bumblebee

Bter\15207759

Linepithema humile

Argentine ant

Lhum\LH13247

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0020e3

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011159

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07216

Tribolium castaneum

Red flour beetle

Tcas\TC013405

Pediculus humanus

Human body louse

Phum\PHUM151060

Rhodnius prolixus

Kissing bug

Rpro\RPRC015393

Cimex lectularius

Bed bug

Clec\CLEC005624

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI065812

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001437

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_05555

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06OO )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Black-legged tick

Isca\ISCW004712

Stegodyphus mimosarum

African social velvet spider

Smim\KFM56617.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58292.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur247g00010

Tetranychus urticae

Two-spotted spider mite

Turt\tetur07g07470

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_194862

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0995 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Atg4hb

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000007827

Gallus gallus

Domestic chicken

Ggal\ATG4B

Gallus gallus

Domestic chicken

Ggal\ATG4A

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

7 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Atg4a^KK108570

ameliorates myotonic dystrophy type 1

modeled by Zzzz\CTG^i480.UAS.cGa

(Bargiela et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ATG4A; autophagy related 4A cysteine peptidase

14 of 15

300663

ATG4B; autophagy related 4B cysteine peptidase

13 of 15

611338

ATG4C; autophagy related 4C cysteine peptidase

5 of 15

611339

ATG4D; autophagy related 4D cysteine peptidase

5 of 15

611340

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Atg4a - CG4407

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - CG8654

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - Cyp6a13

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - Cyp6d4

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - Cyp9f2

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - Fer1HCH

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - Hmgs

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - Hsp60A

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - Lst8

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - MRG15

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - ND-75

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - PSR

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - SPE

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - Sil1

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - Tap42

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - exu

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - hiro

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - igl

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - mts

experimental knowledge based

(Guruharsha et al., 2011)

Atg4a - nwk

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Atg4a

suppressible

Atg8a

(Pircs et al., 2012)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Dcp-1

suppressible

Atg4a

(Kim et al., 2010)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59536

DroID - A comprehensive database of gene and protein interactions.

FBgn0031298

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

33283

MIST (genetic) - An integrated Molecular Interaction Database

Atg4a

MIST (protein-protein) - An integrated Molecular Interaction Database

Atg4a

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Macroautophagy

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-1.5

Cytogenetic map

21E4-21E4

Sequence location

2L:1,080,911..1,085,380 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21E4-21E4

Limits computationally determined from genome sequence between P{lacW}l(2)k09610^k09610&P{lacW}S^k09538a and P{PZ}l(2)10685¹⁰⁶⁸⁵&P{lacW}Tango14^k00619

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-1.5

(FlyBase, 2016)

2-1.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Bloomington

23542

w¹¹¹⁸; Mi{ET1}Atg4a^MB03551

28367

y¹ v¹; P{TRiP.JF03003}attP2

81430

y¹ v¹; P{TKO.GS04627}attP40

44421

y¹ v¹; P{TRiP.GLC01355}attP40

83221

y¹ w^*; TI{CRIMIC.TG4.1}Atg4a^{CR00969-TG4.1}/SM6a

35740

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01482}attP2

VDRC

v107317

P{KK108570}VIE-260B

v34843

w¹¹¹⁸ P{GD11315}v34843

Genomic Clones (6)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (89)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD26292

Other clones

DPiM_LD26292

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031298

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031298

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33283

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Atg4 CG4428

(Scott et al., 2004)

Source for identity of: Atg4a Atg4

(Érdi et al., 2012)

Source for database merge of

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33283

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031298

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031298

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4428

Flygut - An atlas of the Drosophila adult midgut

FBgn0031298

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33283

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013405

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4428

modMine - A data warehouse for the modENCODE project

FBgn0031298

Linkouts

BioGRID - A database of protein and genetic interactions.

59536

DPiM - Drosophila Protein interaction map

FBgn0031298

DroID - A comprehensive database of gene and protein interactions.

FBgn0031298

DRSC - Results frm RNAi screens

FBgn0031298

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0031298

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4428-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031298

FlyMine - An integrated database for Drosophila genomics

FBgn0031298

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

33283

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

Atg4a

MIST (protein-protein) - An integrated Molecular Interaction Database

Atg4a

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Macroautophagy

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

APG4

(Kourtis and Tavernarakis, 2009)

ATG4

(Barth et al., 2012, Wu et al., 2009)

AUT2

(Kourtis and Tavernarakis, 2009)

Atg4a

(Barthez et al., 2020, Jacomin et al., 2020, Guo et al., 2019, Khezri and Rusten, 2019, Meltzer et al., 2019, Billes et al., 2018, Gene Disruption Project members, 2018-, O'Keefe and Denton, 2018, Galluzzi et al., 2017, Manent et al., 2017, Péan et al., 2017, Transgenic RNAi Project members, 2017-, Del Caño-Espinel et al., 2015, Kuhn et al., 2015, Xu et al., 2015, Zhang and Baehrecke, 2015, Érdi et al., 2012, Pircs et al., 2012)

CG4428

(Érdi et al., 2012, Pircs et al., 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Lee et al., 2003, Thumm and Kadowaki, 2001)

atg4

(Singh and Chowdhuri, 2018, Zhang et al., 2016, Kwon et al., 2013, Chen et al., 2012, Kim et al., 2010, Shelly et al., 2009)

Name Synonyms

Autophagy-related 4a

Autophagy-specific gene 4

(Scott et al., 2004)

Autophagy-specific gene 4a

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (84)

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