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Gene Dmel\CG18317

General Information
Symbol	Dmel\CG18317	Species	D. melanogaster
Name		Annotation symbol	CG18317
Feature type	protein_coding_gene	FlyBase ID	FBgn0031359
Gene Model Status	Current	Stock availability	11 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	22B1-22B1	Sequence location	2L:1,716,244..1,724,391 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG18317 (FBgn0031359). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transmembrane transporter activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: mitochondrial transport. 11 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Mitochondrial brown fat uncoupling protein; Mitochondrial carrier domain; Mitochondrial substrate/solute carrier. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult heart. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval trachea, inseminated spermatheca, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625651_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG18317. Gene sequence location is 2L:1716244..1724391.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA00520 BKN28751 HFA00073
FB2011_10	Controlled Vocabulary Terms mitochondrial membrane
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 22B1-22B1   Limits computationally determined from genome sequence between P{PZ}l(2)0411104111 and P{lacW}CG17646k11021
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG18317 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG18317-RA FBtr0077910  NM_134771   1765   365 CG18317-RC FBtr0305618     2399   358 CG18317-RD FBtr0306167     2355   272
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG18317-PA   FBpp0077576   40.5   365   10.18     NP_608615   AAF51345 CG18317-PC   FBpp0294064   39.7   358   10.03       CG18317-PD   FBpp0297297   30.8   272   9.78
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mitochondrial brown fat uncoupling protein (IPR002030) Mitochondrial carrier domain (IPR023395) Mitochondrial substrate/solute carrier (IPR018108)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51345   AI259170   AI260074   AI260825   AI260903   AI293364   AI294352   AW943991   AY058735 AAL13964   BI229966   BI483858   BI574473   BI584552   BI605720   BI611454   BI617216   BI618697   BI622633   BI626172   BI627367   BI636906   BT029116   CK605350   CK659445   CL528173   CO178025   CO178033   CO179910   CO180399   CO180979   CO276636   CO280613   CO284395   CO294802   CO309362   CO319363   CO320867   CO331368   CZ478298   CZ478591   CZ479386   EC063874   EC069731   EC078765   EC081113   EC084804   EC088422   EC213268   EC216472   EC225509   EC227263   EC229599   EC232198
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VQ37
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031359    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031359 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031359 expression level Developmental Stage   Expression Level embryo 00-02hr    1376 embryo 02-04hr    329 embryo 04-06hr    523 embryo 06-08hr    826 embryo 08-10hr    817 embryo 10-12hr    972 embryo 12-14hr    727 embryo 14-16hr    893 embryo 16-18hr    1156 embryo 18-20hr    1543 embryo 20-22hr    1133 embryo 22-24hr    1175 larva L1    1260 larva L2    902 larva L3 12hr old    1052 larva L3 puffstage 1-2    1080 larva L3 puffstage 3-6    1454 larva L3 puffstage 7-9    2109 white prepupae new    2830 white prepupae 12hr    1229 white prepupae 24hr    1101 pupae 2d postWPP    1193 pupae 3d postWPP    1616 pupae 4d postWPP    2924 adult male 01day    3660 adult male 05day    4136 adult male 30day    3344 adult female 01day    2947 adult female 05day    1819 adult female 30day    1439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1376) embryo 02-04hr  (329) embryo 04-06hr  (523) embryo 06-08hr  (826) embryo 08-10hr  (817) embryo 10-12hr  (972) embryo 12-14hr  (727) embryo 14-16hr  (893) embryo 16-18hr  (1156) embryo 18-20hr  (1543) embryo 20-22hr  (1133) embryo 22-24hr  (1175) larva L1  (1260) larva L2  (902) larva L3 12hr old  (1052) larva L3 puffstage 1-2  (1080) larva L3 puffstage 3-6  (1454) larva L3 puffstage 7-9  (2109) white prepupae new  (2830) white prepupae 12hr  (1229) white prepupae 24hr  (1101) pupae 2d postWPP  (1193) pupae 3d postWPP  (1616) pupae 4d postWPP  (2924) adult male 01day  (3660) adult male 05day  (4136) adult male 30day  (3344) adult female 01day  (2947) adult female 05day  (1819) adult female 30day  (1439) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1376 embryo 02-04hr    329 embryo 04-06hr    523 embryo 06-08hr    826 embryo 08-10hr    817 embryo 10-12hr    972 embryo 12-14hr    727 embryo 14-16hr    893 embryo 16-18hr    1156 embryo 18-20hr  (1543) embryo 20-22hr    1133 embryo 22-24hr    1175 larva L1    1260 larva L2    902 larva L3 12hr old    1052 larva L3 puffstage 1-2    1080 larva L3 puffstage 3-6  1454 larva L3 puffstage 7-9  (2109) white prepupae new  (2830) white prepupae 12hr    1229 white prepupae 24hr    1101 pupae 2d postWPP    1193 pupae 3d postWPP  (1616) pupae 4d postWPP  (2924) adult male 01day  (3660) adult male 05day  (4136) adult male 30day  (3344) adult female 01day  (2947) adult female 05day  (1819) adult female 30day  1439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1376 embryo 02-04hr    329 embryo 04-06hr    523 embryo 06-08hr    826 embryo 08-10hr    817 embryo 10-12hr    972 embryo 12-14hr    727 embryo 14-16hr    893 embryo 16-18hr    1156 embryo 18-20hr    1543 embryo 20-22hr    1133 embryo 22-24hr    1175 larva L1    1260 larva L2    902 larva L3 12hr old    1052 larva L3 puffstage 1-2    1080 larva L3 puffstage 3-6    1454 larva L3 puffstage 7-9    2109 white prepupae new    2830 white prepupae 12hr    1229 white prepupae 24hr    1101 pupae 2d postWPP    1193 pupae 3d postWPP    1616 pupae 4d postWPP    2924 adult male 01day    3660 adult male 05day    4136 adult male 30day    3344 adult female 01day    2947 adult female 05day    1819 adult female 30day    1439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1376 embryo 02-04hr    329 embryo 04-06hr    523 embryo 06-08hr    826 embryo 08-10hr    817 embryo 10-12hr    972 embryo 12-14hr    727 embryo 14-16hr    893 embryo 16-18hr    1156 embryo 18-20hr    1543 embryo 20-22hr    1133 embryo 22-24hr    1175 larva L1    1260 larva L2    902 larva L3 12hr old    1052 larva L3 puffstage 1-2    1080 larva L3 puffstage 3-6    1454 larva L3 puffstage 7-9    2109 white prepupae new    2830 white prepupae 12hr    1229 white prepupae 24hr    1101 pupae 2d postWPP    1193 pupae 3d postWPP    1616 pupae 4d postWPP    2924 adult male 01day    3660 adult male 05day    4136 adult male 30day    3344 adult female 01day    2947 adult female 05day    1819 adult female 30day    1439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031359 expression level Developmental Stage   Expression Level embryo 00-02hr    1376 embryo 02-04hr    329 embryo 04-06hr    523 embryo 06-08hr    826 embryo 08-10hr    817 embryo 10-12hr    972 embryo 12-14hr    727 embryo 14-16hr    893 embryo 16-18hr    1156 embryo 18-20hr    1543 embryo 20-22hr    1133 embryo 22-24hr    1175 larva L1    1260 larva L2    902 larva L3 12hr old    1052 larva L3 puffstage 1-2    1080 larva L3 puffstage 3-6    1454 larva L3 puffstage 7-9    2109 white prepupae new    2830 white prepupae 12hr    1229 white prepupae 24hr    1101 pupae 2d postWPP    1193 pupae 3d postWPP    1616 pupae 4d postWPP    2924 adult male 01day    3660 adult male 05day    4136 adult male 30day    3344 adult female 01day    2947 adult female 05day    1819 adult female 30day    1439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1376) embryo 02-04hr  (329) embryo 04-06hr  (523) embryo 06-08hr  (826) embryo 08-10hr  (817) embryo 10-12hr  (972) embryo 12-14hr  (727) embryo 14-16hr  (893) embryo 16-18hr  (1156) embryo 18-20hr  (1543) embryo 20-22hr  (1133) embryo 22-24hr  (1175) larva L1  (1260) larva L2  (902) larva L3 12hr old  (1052) larva L3 puffstage 1-2  (1080) larva L3 puffstage 3-6  (1454) larva L3 puffstage 7-9  (2109) white prepupae new  (2830) white prepupae 12hr  (1229) white prepupae 24hr  (1101) pupae 2d postWPP  (1193) pupae 3d postWPP  (1616) pupae 4d postWPP  (2924) adult male 01day  (3660) adult male 05day  (4136) adult male 30day  (3344) adult female 01day  (2947) adult female 05day  (1819) adult female 30day  (1439) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1376 embryo 02-04hr    329 embryo 04-06hr    523 embryo 06-08hr    826 embryo 08-10hr    817 embryo 10-12hr    972 embryo 12-14hr    727 embryo 14-16hr    893 embryo 16-18hr    1156 embryo 18-20hr  1543 embryo 20-22hr    1133 embryo 22-24hr    1175 larva L1    1260 larva L2    902 larva L3 12hr old    1052 larva L3 puffstage 1-2    1080 larva L3 puffstage 3-6  1454 larva L3 puffstage 7-9  2109 white prepupae new  (2830) white prepupae 12hr    1229 white prepupae 24hr    1101 pupae 2d postWPP    1193 pupae 3d postWPP  1616 pupae 4d postWPP  (2924) adult male 01day  (3660) adult male 05day  (4136) adult male 30day  (3344) adult female 01day  (2947) adult female 05day  1819 adult female 30day  1439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1376 embryo 02-04hr    329 embryo 04-06hr    523 embryo 06-08hr    826 embryo 08-10hr    817 embryo 10-12hr    972 embryo 12-14hr    727 embryo 14-16hr    893 embryo 16-18hr    1156 embryo 18-20hr    1543 embryo 20-22hr    1133 embryo 22-24hr    1175 larva L1    1260 larva L2    902 larva L3 12hr old    1052 larva L3 puffstage 1-2    1080 larva L3 puffstage 3-6    1454 larva L3 puffstage 7-9    2109 white prepupae new    2830 white prepupae 12hr    1229 white prepupae 24hr    1101 pupae 2d postWPP    1193 pupae 3d postWPP    1616 pupae 4d postWPP    2924 adult male 01day    3660 adult male 05day    4136 adult male 30day    3344 adult female 01day    2947 adult female 05day    1819 adult female 30day    1439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1376 embryo 02-04hr    329 embryo 04-06hr    523 embryo 06-08hr    826 embryo 08-10hr    817 embryo 10-12hr    972 embryo 12-14hr    727 embryo 14-16hr    893 embryo 16-18hr    1156 embryo 18-20hr    1543 embryo 20-22hr    1133 embryo 22-24hr    1175 larva L1    1260 larva L2    902 larva L3 12hr old    1052 larva L3 puffstage 1-2    1080 larva L3 puffstage 3-6    1454 larva L3 puffstage 7-9    2109 white prepupae new    2830 white prepupae 12hr    1229 white prepupae 24hr    1101 pupae 2d postWPP    1193 pupae 3d postWPP    1616 pupae 4d postWPP    2924 adult male 01day    3660 adult male 05day    4136 adult male 30day    3344 adult female 01day    2947 adult female 05day    1819 adult female 30day    1439 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031359    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031359 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult heart. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval trachea, inseminated spermatheca, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031359 expression level Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut no informative data Larval Hindgut    151.8 Larval Malpighian Tubules    248.4 Larval Fat Body    114 Larval Salivary Gland    41.2 Larval Trachea    162.8 Larval Carcass    61.25 Adult Head    156.2 Adult Eye    466.2 Adult Brain    163 Adult Thoracic-Abdominal Ganglion    119.3 Adult Crop    88.2 Adult Midgut no informative data Adult Hindgut    277.3 Adult Malpighian Tubules    222 Adult Fat Body    167.6 Adult Salivary Gland no informative data Adult Heart    804.9 Adult VirginFemale Spermatheca    91.2 Adult InseminatedFemale Spermatheca    138.4 Adult Ovary    51 Adult Testis    27.5 Adult Male Accessory Gland    138.9 Adult Carcass    303.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut no informative data Larval Hindgut    151.8 Larval Malpighian Tubules    248.4 Larval Fat Body    114 Larval Salivary Gland    41.2 Larval Trachea    162.8 Larval Carcass    61.25 Adult Head    156.2 Adult Eye    466.2 Adult Brain    163 Adult Thoracic-Abdominal Ganglion    119.3 Adult Crop    88.2 Adult Midgut no informative data Adult Hindgut    277.3 Adult Malpighian Tubules    222 Adult Fat Body    167.6 Adult Salivary Gland no informative data Adult Heart  (804.9) Adult VirginFemale Spermatheca    91.2 Adult InseminatedFemale Spermatheca    138.4 Adult Ovary    51 Adult Testis    27.5 Adult Male Accessory Gland    138.9 Adult Carcass    303.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut no informative data Larval Hindgut    151.8 Larval Malpighian Tubules    248.4 Larval Fat Body    114 Larval Salivary Gland    41.2 Larval Trachea    162.8 Larval Carcass    61.25 Adult Head    156.2 Adult Eye    466.2 Adult Brain    163 Adult Thoracic-Abdominal Ganglion    119.3 Adult Crop    88.2 Adult Midgut no informative data Adult Hindgut    277.3 Adult Malpighian Tubules    222 Adult Fat Body    167.6 Adult Salivary Gland no informative data Adult Heart    804.9 Adult VirginFemale Spermatheca    91.2 Adult InseminatedFemale Spermatheca    138.4 Adult Ovary    51 Adult Testis    27.5 Adult Male Accessory Gland    138.9 Adult Carcass    303.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut no informative data Larval Hindgut    151.8 Larval Malpighian Tubules    248.4 Larval Fat Body    114 Larval Salivary Gland    41.2 Larval Trachea    162.8 Larval Carcass    61.25 Adult Head    156.2 Adult Eye    466.2 Adult Brain    163 Adult Thoracic-Abdominal Ganglion    119.3 Adult Crop    88.2 Adult Midgut no informative data Adult Hindgut    277.3 Adult Malpighian Tubules    222 Adult Fat Body    167.6 Adult Salivary Gland no informative data Adult Heart    804.9 Adult VirginFemale Spermatheca    91.2 Adult InseminatedFemale Spermatheca    138.4 Adult Ovary    51 Adult Testis    27.5 Adult Male Accessory Gland    138.9 Adult Carcass    303.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031359 expression level Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut no informative data Larval Hindgut    151.8 Larval Malpighian Tubules    248.4 Larval Fat Body    114 Larval Salivary Gland    41.2 Larval Trachea    162.8 Larval Carcass    61.25 Adult Head    156.2 Adult Eye    466.2 Adult Brain    163 Adult Thoracic-Abdominal Ganglion    119.3 Adult Crop    88.2 Adult Midgut no informative data Adult Hindgut    277.3 Adult Malpighian Tubules    222 Adult Fat Body    167.6 Adult Salivary Gland no informative data Adult Heart    804.9 Adult VirginFemale Spermatheca    91.2 Adult InseminatedFemale Spermatheca    138.4 Adult Ovary    51 Adult Testis    27.5 Adult Male Accessory Gland    138.9 Adult Carcass    303.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut no informative data Larval Hindgut    151.8 Larval Malpighian Tubules    248.4 Larval Fat Body    114 Larval Salivary Gland    41.2 Larval Trachea    162.8 Larval Carcass    61.25 Adult Head    156.2 Adult Eye    466.2 Adult Brain    163 Adult Thoracic-Abdominal Ganglion    119.3 Adult Crop    88.2 Adult Midgut no informative data Adult Hindgut    277.3 Adult Malpighian Tubules    222 Adult Fat Body    167.6 Adult Salivary Gland no informative data Adult Heart  804.9 Adult VirginFemale Spermatheca    91.2 Adult InseminatedFemale Spermatheca    138.4 Adult Ovary    51 Adult Testis    27.5 Adult Male Accessory Gland    138.9 Adult Carcass    303.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut no informative data Larval Hindgut    151.8 Larval Malpighian Tubules    248.4 Larval Fat Body    114 Larval Salivary Gland    41.2 Larval Trachea    162.8 Larval Carcass    61.25 Adult Head    156.2 Adult Eye    466.2 Adult Brain    163 Adult Thoracic-Abdominal Ganglion    119.3 Adult Crop    88.2 Adult Midgut no informative data Adult Hindgut    277.3 Adult Malpighian Tubules    222 Adult Fat Body    167.6 Adult Salivary Gland no informative data Adult Heart    804.9 Adult VirginFemale Spermatheca    91.2 Adult InseminatedFemale Spermatheca    138.4 Adult Ovary    51 Adult Testis    27.5 Adult Male Accessory Gland    138.9 Adult Carcass    303.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    47.4 Larval Midgut no informative data Larval Hindgut    151.8 Larval Malpighian Tubules    248.4 Larval Fat Body    114 Larval Salivary Gland    41.2 Larval Trachea    162.8 Larval Carcass    61.25 Adult Head    156.2 Adult Eye    466.2 Adult Brain    163 Adult Thoracic-Abdominal Ganglion    119.3 Adult Crop    88.2 Adult Midgut no informative data Adult Hindgut    277.3 Adult Malpighian Tubules    222 Adult Fat Body    167.6 Adult Salivary Gland no informative data Adult Heart    804.9 Adult VirginFemale Spermatheca    91.2 Adult InseminatedFemale Spermatheca    138.4 Adult Ovary    51 Adult Testis    27.5 Adult Male Accessory Gland    138.9 Adult Carcass    303.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    156.2   NA  Eye    466.2   NA  Brain    163   47.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    119.3   NA  Crop    88.2   no informative data  Midgut    no informative data   151.8  Hindgut    277.3   248.4  Malpighian Tubules    222   114  Fat Body    167.6   41.2  Salivary Gland    no informative data   NA  Heart    804.9   162.8  Trachea    NA   NA  VirginFemale Spermatheca    91.2   NA  InseminatedFemale Spermatheca    138.4   NA  Ovary    51   NA  Testis    27.5   NA  Male Accessory Gland    138.9   61.25  Carcass    303.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031359 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18317-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG18317GD807 Phenotype manifest in Allele
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of CG18317 Class Mutagen Stocks Known lesion CG18317EY09480 P-element activity 2 -- CG18317BG02028 1 -- CG18317CB-0908-3 1 -- CG18317e00411 piggyBac transposase 1 -- CG18317e00681 1 -- CG18317e01575 piggyBac transposase 1 -- CG18317MI02194 1 -- CG18317e00741 piggyBac transposase 0 -- CG18317frtz-7 X ray 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG18317 Class Mutagen Stocks Known lesion CG18317GD807 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG18317KK108751 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6005 (Ryder, 2004.4.26)
Partially disrupted in	Df(2L)frtz7 (Collier et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD807} NA P{KK108751} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG18317EY09480 NA miscellaneous insertions Mi{MIC}CG18317MI02194 NA P{GT1}CG18317BG02028 NA P{RS3}CG18317CB-0908-3 NA PBac{RB}CG18317e00411 NA PBac{RB}CG18317e00681 NA PBac{RB}CG18317e00741 NA PBac{RB}CG18317e01575 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
transmembrane transporter activity inferred from sequence or structural similarity (Nelson, 2000.4.10)
Biological Process
CV term Evidence References
mitochondrial transport inferred from electronic annotation with InterPro:IPR002030 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
mitochondrial envelope inferred from sequence or structural similarity (Nelson, 2000.4.10) mitochondrial membrane inferred from electronic annotation with InterPro:IPR002030 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG18317 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59590 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031359 DroID - A comprehensive database of gene and protein interactions. • FBgn0031359 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33350
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24384 Dere\GG24580 Dgri\GH11479 Dmoj\GI16974 Dper\GL19343 Dpse\GA25925 Dsec\GM16599 Dsim\GD22900 Dvir\GJ17220 Dwil\GK14935 Dyak\GE15478
Curated drosophilid orthologs	Dpse\GA14885
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012117-PA Aedes aegypti (mosquito) AGAP009333-PA Anopheles gambiae (mosquito) XP_623212.1 Apis mellifera (honey bee) XP_001951913.1 Acyrthosiphon pisum (pea aphid) 20179 Batrachochytrium dendrobatidis (chytrid fungus) 127465 Branchiostoma floridae (lancelet) XP_001894601.1 Brugia malayi (roundworm nematode) BGIBMGA007487-PA Bombyx mori (silk worm) ENSBTAP00000020353 Bos taurus (bovine) CAL0002049 Candida albicans (a form of yeast) CN06413 Caenorhabditis brenneri (small nematode) CN25113 Caenorhabditis brenneri (small nematode) CBP00791 Caenorhabditis briggsae (nematode) CE02342 Caenorhabditis elegans (worm) ENSCAFP00000029201 Canis familiaris (dog) CAGL0M05225g Candida glabrata (haploid yeast) ENSCINP00000003249 Ciona intestinalis (sea squirt) JA02688 Caenorhabditis japonica (nematode) CMM222C Cyanidioschyzon merolae (red alga) cn04226 Cryptococcus neoformans (yeast-like fungus) CPIJ004795 Culex pipens (mosquito) ENSCPOP00000020544 Cavia porcellus (guinea pig) RP40912 Caenorhabditis remanei (nematode) 182193 Capitella spl (polychaete worm) DDB0214832 Dictyostelium discoideum (amoeba) DEHA2F08448g Debaryomyces Hansenii (yeast) 189549 Daphnia pulex (daphnia) ENSDARP00000004962 Danio rerio (zebra fish) ENSECAP00000008084 Equus caballus (horse) ENSGACP00000020416 Gymnopilus aculeatus (mushroom) ENSGALP00000008458 Gallus gallus (chicken) 70217 Hypsipyla robusta (cedar shoot borer) ENSP00000320688 Homo sapiens (human) ISCW010343-PA Ixodes scapularis (deer tick) KLLA0E23629g Kluyveromyces lactis (yeast) LmjF35.3330 Leishmania major (virus) 28866 Monocosta brevicollis (choanoflagellate) ENSMODP00000023225 Monodelphis domestica (gray opossum) ENSMMUP00000029164 Macaca mulatta (rhesus monkey) ENSMUSP00000082302 Mus musculus (house mouse) 196580 Nematostella vectensis (starlet anemone) XP_001602784.1 Nasonia vitripennis (wasp) ENSOANP00000001810 Ornithorynchus anatinus (platypus) ENSORLP00000017524 Oryzias latipes (japanese killifish) PHUM001250-PA Pediculus humanus (human body louse) ENSPPYP00000015842 Pongo pygmaeus (orangutan) 129848 Phytophthora sojae (root rot pathogen) ENSPTRP00000026635 Pan troglodytes (chimpanzee) ENSRNOP00000033519 Rattus norvegicus (norway rat) YBR192W Saccharomyces cerevisiae (budding yeast) Smp_061250 Schistosoma mansoni (trematode parasite) SPAC688.09 Schizosaccharomyces pombe (fission yeast) 56268 Trichoplax adhaerens (metazoa) XP_975115.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014018 Tetraodon nigroviridis (green spotted pufferfish) 32066 Thalassiosira pseudonana (marine diatom) ENSTRUP00000000559 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000044795 Xenopus tropicalis (frog) YALI0F05500g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11086 LH24022 ISCW010343 FBgn0233054 FBgn0216940 FBgn0204396 FBgn0194294 FBgn0171512 JGI_V11_189549 FBgn0247302 FBgn0156942 FBgn0152722 FBgn0139720 FBgn0118959 FBgn0116712 FBgn0101378 CPIJ004795 BGIBMGA007487 ACYPI009821 GB14650 AGAP009333 AAEL012117 PB25098 PHUM332840 GLEAN_06415
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	12652 w1118; P{GT1}CG18317BG02028 34290 y1 w*; Mi{MIC}CG18317MI02194/SM6a 16447 y1 w67c23; P{EPgy2}CG18317EY09480/CyO
Harvard	- PBac{RB}CG18317e00411 - PBac{RB}CG18317e00681 - PBac{RB}CG18317e01575
Kyoto	123371 w1118; P{RS3}CG18317CB-0908-3 111727 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{EPgy2}CG18317EY09480 P{neoFRT}40A/CyO y+
VDRC	v100807 P{KK108751}VIE-260B v44203 w1118; P{GD807}v44203 v44202 w1118; P{GD807}v44202/TM3
Genomic Clones ( 1 )
	BACR19B15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 35 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP15292 LP02521
Other clones	DPiM_LP02521
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP03756 LP04812 LP04906 LP04907 LP07706 LP17216 RE27871 RE66814 RH17673 RH23675 RH23791 RH47480 RH49578 RH54536 RH66721 RH68657 RH71606 SD18751 UT01865
Other clones	EC00505 EC01505 EC13282 EK055026 EK055039 EK121721 EK154458 EK165950 EK207714 EK217429 EK277751 EK288549 EK299416
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031359 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33350
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134771 RefSeq (Proteins) • NP_608615 DDBJ / EMBL / GenBank • AAF51345 AAL13964 AI259170 AW943991 AY058735 CL528173 CZ478298 CZ478591 CZ479386 Entrez Gene - A searchable database of RefSeq genes. • 33350 UniProtKB/TrEMBL • Q9VQ37
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mitochondrial brown fat uncoupling protein (IPR002030) Mitochondrial carrier domain (IPR023395) Mitochondrial substrate/solute carrier (IPR018108)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59590 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031359 DroID - A comprehensive database of gene and protein interactions. • FBgn0031359 DRSC - Results from RNAi screens. • FBgn0031359 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031359 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18317-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031359 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33350 InParanoid A subset of ortholog calls from InParanoid. • AAEL012117-PA Aedes aegypti (mosquito) AGAP009333-PA Anopheles gambiae (mosquito) XP_623212.1 Apis mellifera (honey bee) XP_001951913.1 Acyrthosiphon pisum (pea aphid) 20179 Batrachochytrium dendrobatidis (chytrid fungus) 127465 Branchiostoma floridae (lancelet) XP_001894601.1 Brugia malayi (roundworm nematode) BGIBMGA007487-PA Bombyx mori (silk worm) ENSBTAP00000020353 Bos taurus (bovine) CAL0002049 Candida albicans (a form of yeast) CN06413 Caenorhabditis brenneri (small nematode) CN25113 Caenorhabditis brenneri (small nematode) CBP00791 Caenorhabditis briggsae (nematode) CE02342 Caenorhabditis elegans (worm) ENSCAFP00000029201 Canis familiaris (dog) CAGL0M05225g Candida glabrata (haploid yeast) ENSCINP00000003249 Ciona intestinalis (sea squirt) JA02688 Caenorhabditis japonica (nematode) CMM222C Cyanidioschyzon merolae (red alga) cn04226 Cryptococcus neoformans (yeast-like fungus) CPIJ004795 Culex pipens (mosquito) ENSCPOP00000020544 Cavia porcellus (guinea pig) RP40912 Caenorhabditis remanei (nematode) 182193 Capitella spl (polychaete worm) DDB0214832 Dictyostelium discoideum (amoeba) DEHA2F08448g Debaryomyces Hansenii (yeast) 189549 Daphnia pulex (daphnia) ENSDARP00000004962 Danio rerio (zebra fish) ENSECAP00000008084 Equus caballus (horse) ENSGACP00000020416 Gymnopilus aculeatus (mushroom) ENSGALP00000008458 Gallus gallus (chicken) 70217 Hypsipyla robusta (cedar shoot borer) ENSP00000320688 Homo sapiens (human) ISCW010343-PA Ixodes scapularis (deer tick) KLLA0E23629g Kluyveromyces lactis (yeast) LmjF35.3330 Leishmania major (virus) 28866 Monocosta brevicollis (choanoflagellate) ENSMODP00000023225 Monodelphis domestica (gray opossum) ENSMMUP00000029164 Macaca mulatta (rhesus monkey) ENSMUSP00000082302 Mus musculus (house mouse) 196580 Nematostella vectensis (starlet anemone) XP_001602784.1 Nasonia vitripennis (wasp) ENSOANP00000001810 Ornithorynchus anatinus (platypus) ENSORLP00000017524 Oryzias latipes (japanese killifish) PHUM001250-PA Pediculus humanus (human body louse) ENSPPYP00000015842 Pongo pygmaeus (orangutan) 129848 Phytophthora sojae (root rot pathogen) ENSPTRP00000026635 Pan troglodytes (chimpanzee) ENSRNOP00000033519 Rattus norvegicus (norway rat) YBR192W Saccharomyces cerevisiae (budding yeast) Smp_061250 Schistosoma mansoni (trematode parasite) SPAC688.09 Schizosaccharomyces pombe (fission yeast) 56268 Trichoplax adhaerens (metazoa) XP_975115.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014018 Tetraodon nigroviridis (green spotted pufferfish) 32066 Thalassiosira pseudonana (marine diatom) ENSTRUP00000000559 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000044795 Xenopus tropicalis (frog) YALI0F05500g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33350 modMine - Data generated by the modENCODE project. • FBgn0031359 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11086 LH24022 ISCW010343 FBgn0233054 FBgn0216940 FBgn0204396 FBgn0194294 FBgn0171512 JGI_V11_189549 FBgn0247302 FBgn0156942 FBgn0152722 FBgn0139720 FBgn0118959 FBgn0116712 FBgn0101378 CPIJ004795 BGIBMGA007487 ACYPI009821 GB14650 AGAP009333 AAEL012117 PB25098 PHUM332840 GLEAN_06415
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG18317 (Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 15 )
Research paper	Collier et al., 2005, Genetics 169(4): 2035--2045 The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis. [FBrf0187636]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2011.1.31, set919.xml set919.xml [FBrf0212923] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Nelson, 2000.4.10, Mitochondrial carrier genes. Mitochondrial carrier genes. [FBrf0126915]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]