Gene Dmel\CG31937

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General Information

Symbol

Dmel\CG31937

Species

D. melanogaster

Name

Annotation symbol

CG31937

Feature type

protein_coding_gene

FlyBase ID

FBgn0031360

Gene Model Status

Current

Stock availability

1 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

22B1-22B1

Sequence location

2L:1,729,887..1,731,070 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG31937 (FBgn0031360). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: metabolic process. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Glucose/ribitol dehydrogenase; NAD(P)-binding domain; Short-chain dehydrogenase/reductase SDR. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the larval period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules, adult heart, adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1623020_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG31937. Gene sequence location is 2L:1729887..1731070.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

22B1-22B1

Limits computationally determined from genome sequence between P{PZ}l(2)04111⁰⁴¹¹¹ and P{lacW}CG17646^k11021

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG31937 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG31937-RA

FBtr0077884

NM_134772

1184

321

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG31937-PA

FBpp0077552

35.7

321

8.78

NP_608616

AAF51343

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Short-chain dehydrogenase/reductase SDR (IPR002198)

Glucose/ribitol dehydrogenase (IPR002347)

NAD(P)-binding domain (IPR016040)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

(Fisher et al., 2012)

Comment:maternally deposited

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval visceral muscle

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules, adult heart, adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		87.3
Larval Midgut		440.7
Larval Hindgut		295.5
Larval Malpighian Tubules		722.5
Larval Fat Body		264.1
Larval Salivary Gland		112
Larval Trachea		478.25
Larval Carcass		218.9
Adult Head		360.7
Adult Eye		260.1
Adult Brain		81.5
Adult Thoracic-Abdominal Ganglion		110.5
Adult Crop		385.6
Adult Midgut		242.1
Adult Hindgut		339.2
Adult Malpighian Tubules		1412.8
Adult Fat Body		1030.1
Adult Salivary Gland		288
Adult Heart		720.725
Adult VirginFemale Spermatheca		857.1
Adult InseminatedFemale Spermatheca		712.7
Adult Ovary		179.1
Adult Testis		76.1
Adult Male Accessory Gland		245.4
Adult Carcass		813.4
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		87.3
Larval Midgut		440.7
Larval Hindgut		295.5
Larval Malpighian Tubules		(722.5)
Larval Fat Body		264.1
Larval Salivary Gland		112
Larval Trachea		478.25
Larval Carcass		218.9
Adult Head		360.7
Adult Eye		260.1
Adult Brain		81.5
Adult Thoracic-Abdominal Ganglion		110.5
Adult Crop		385.6
Adult Midgut		242.1
Adult Hindgut		339.2
Adult Malpighian Tubules		(1412.8)
Adult Fat Body		(1030.1)
Adult Salivary Gland		288
Adult Heart		(720.725)
Adult VirginFemale Spermatheca		(857.1)
Adult InseminatedFemale Spermatheca		(712.7)
Adult Ovary		179.1
Adult Testis		76.1
Adult Male Accessory Gland		245.4
Adult Carcass		(813.4)
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		87.3
Larval Midgut		440.7
Larval Hindgut		295.5
Larval Malpighian Tubules		722.5
Larval Fat Body		264.1
Larval Salivary Gland		112
Larval Trachea		478.25
Larval Carcass		218.9
Adult Head		360.7
Adult Eye		260.1
Adult Brain		81.5
Adult Thoracic-Abdominal Ganglion		110.5
Adult Crop		385.6
Adult Midgut		242.1
Adult Hindgut		339.2
Adult Malpighian Tubules		(1412.8)
Adult Fat Body		1030.1
Adult Salivary Gland		288
Adult Heart		720.725
Adult VirginFemale Spermatheca		857.1
Adult InseminatedFemale Spermatheca		712.7
Adult Ovary		179.1
Adult Testis		76.1
Adult Male Accessory Gland		245.4
Adult Carcass		813.4
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		87.3
Larval Midgut		440.7
Larval Hindgut		295.5
Larval Malpighian Tubules		722.5
Larval Fat Body		264.1
Larval Salivary Gland		112
Larval Trachea		478.25
Larval Carcass		218.9
Adult Head		360.7
Adult Eye		260.1
Adult Brain		81.5
Adult Thoracic-Abdominal Ganglion		110.5
Adult Crop		385.6
Adult Midgut		242.1
Adult Hindgut		339.2
Adult Malpighian Tubules		1412.8
Adult Fat Body		1030.1
Adult Salivary Gland		288
Adult Heart		720.725
Adult VirginFemale Spermatheca		857.1
Adult InseminatedFemale Spermatheca		712.7
Adult Ovary		179.1
Adult Testis		76.1
Adult Male Accessory Gland		245.4
Adult Carcass		813.4
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		87.3
Larval Midgut		440.7
Larval Hindgut		295.5
Larval Malpighian Tubules		722.5
Larval Fat Body		264.1
Larval Salivary Gland		112
Larval Trachea		478.25
Larval Carcass		218.9
Adult Head		360.7
Adult Eye		260.1
Adult Brain		81.5
Adult Thoracic-Abdominal Ganglion		110.5
Adult Crop		385.6
Adult Midgut		242.1
Adult Hindgut		339.2
Adult Malpighian Tubules		1412.8
Adult Fat Body		1030.1
Adult Salivary Gland		288
Adult Heart		720.725
Adult VirginFemale Spermatheca		857.1
Adult InseminatedFemale Spermatheca		712.7
Adult Ovary		179.1
Adult Testis		76.1
Adult Male Accessory Gland		245.4
Adult Carcass		813.4
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		87.3
Larval Midgut		440.7
Larval Hindgut		295.5
Larval Malpighian Tubules		722.5
Larval Fat Body		264.1
Larval Salivary Gland		112
Larval Trachea		478.25
Larval Carcass		218.9
Adult Head		360.7
Adult Eye		260.1
Adult Brain		81.5
Adult Thoracic-Abdominal Ganglion		110.5
Adult Crop		385.6
Adult Midgut		242.1
Adult Hindgut		339.2
Adult Malpighian Tubules		(1412.8)
Adult Fat Body		(1030.1)
Adult Salivary Gland		288
Adult Heart		720.725
Adult VirginFemale Spermatheca		(857.1)
Adult InseminatedFemale Spermatheca		712.7
Adult Ovary		179.1
Adult Testis		76.1
Adult Male Accessory Gland		245.4
Adult Carcass		813.4
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		87.3
Larval Midgut		440.7
Larval Hindgut		295.5
Larval Malpighian Tubules		722.5
Larval Fat Body		264.1
Larval Salivary Gland		112
Larval Trachea		478.25
Larval Carcass		218.9
Adult Head		360.7
Adult Eye		260.1
Adult Brain		81.5
Adult Thoracic-Abdominal Ganglion		110.5
Adult Crop		385.6
Adult Midgut		242.1
Adult Hindgut		339.2
Adult Malpighian Tubules		1412.8
Adult Fat Body		1030.1
Adult Salivary Gland		288
Adult Heart		720.725
Adult VirginFemale Spermatheca		857.1
Adult InseminatedFemale Spermatheca		712.7
Adult Ovary		179.1
Adult Testis		76.1
Adult Male Accessory Gland		245.4
Adult Carcass		813.4
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		87.3
Larval Midgut		440.7
Larval Hindgut		295.5
Larval Malpighian Tubules		722.5
Larval Fat Body		264.1
Larval Salivary Gland		112
Larval Trachea		478.25
Larval Carcass		218.9
Adult Head		360.7
Adult Eye		260.1
Adult Brain		81.5
Adult Thoracic-Abdominal Ganglion		110.5
Adult Crop		385.6
Adult Midgut		242.1
Adult Hindgut		339.2
Adult Malpighian Tubules		1412.8
Adult Fat Body		1030.1
Adult Salivary Gland		288
Adult Heart		720.725
Adult VirginFemale Spermatheca		857.1
Adult InseminatedFemale Spermatheca		712.7
Adult Ovary		179.1
Adult Testis		76.1
Adult Male Accessory Gland		245.4
Adult Carcass		813.4
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	360.7
NA	Eye	260.1
NA	Brain	81.5
87.3	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	110.5
NA	Crop	385.6
440.7	Midgut	242.1
295.5	Hindgut	339.2
722.5	Malpighian Tubules	1412.8
264.1	Fat Body	1030.1
112	Salivary Gland	288
NA	Heart	720.725
478.25	Trachea	NA
NA	VirginFemale Spermatheca	857.1
NA	InseminatedFemale Spermatheca	712.7
NA	Ovary	179.1
NA	Testis	76.1
NA	Male Accessory Gland	245.4
218.9	Carcass	813.4

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		15
central nervous system, larvae L3		5
central nervous system, pupae P8		4
head, virgin 1-day female		14
head, virgin 4-day female		21
head, virgin 20-day female		47
head, mated 1-day female		13
head, mated 4-day female		21
head, mated 20-day female		36
head, mated 1-day male		21
head, mated 4-day male		28
head, mated 20-day male		43
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		35
digestive system, 4-day adult		24
digestive system, 20-day adult		36
fat body, larvae L3 wandering		13
fat body, white prepupae		10
fat body, pupae P8		10
carcass, larvae L3 wandering		10
carcass, 1-day adult		24
carcass, 4-day adult		29
carcass, 20-day adult		42
ovary, virgin 4-day female		22
ovary, mated 4-day female		15
testis, mated 4-day male		13
accessory gland, mated 4-day male		16
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		15
central nervous system, larvae L3		5
central nervous system, pupae P8		4
head, virgin 1-day female		14
head, virgin 4-day female		21
head, virgin 20-day female		(47)
head, mated 1-day female		13
head, mated 4-day female		21
head, mated 20-day female		(36)
head, mated 1-day male		21
head, mated 4-day male		(28)
head, mated 20-day male		(43)
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		(35)
digestive system, 4-day adult		24
digestive system, 20-day adult		(36)
fat body, larvae L3 wandering		13
fat body, white prepupae		10
fat body, pupae P8		10
carcass, larvae L3 wandering		10
carcass, 1-day adult		24
carcass, 4-day adult		(29)
carcass, 20-day adult		(42)
ovary, virgin 4-day female		22
ovary, mated 4-day female		15
testis, mated 4-day male		13
accessory gland, mated 4-day male		16
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		15
central nervous system, larvae L3		5
central nervous system, pupae P8		4
head, virgin 1-day female		14
head, virgin 4-day female		21
head, virgin 20-day female		47
head, mated 1-day female		13
head, mated 4-day female		21
head, mated 20-day female		36
head, mated 1-day male		21
head, mated 4-day male		28
head, mated 20-day male		43
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		35
digestive system, 4-day adult		24
digestive system, 20-day adult		36
fat body, larvae L3 wandering		13
fat body, white prepupae		10
fat body, pupae P8		10
carcass, larvae L3 wandering		10
carcass, 1-day adult		24
carcass, 4-day adult		29
carcass, 20-day adult		42
ovary, virgin 4-day female		22
ovary, mated 4-day female		15
testis, mated 4-day male		13
accessory gland, mated 4-day male		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		15
central nervous system, larvae L3		5
central nervous system, pupae P8		4
head, virgin 1-day female		14
head, virgin 4-day female		21
head, virgin 20-day female		47
head, mated 1-day female		13
head, mated 4-day female		21
head, mated 20-day female		36
head, mated 1-day male		21
head, mated 4-day male		28
head, mated 20-day male		43
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		35
digestive system, 4-day adult		24
digestive system, 20-day adult		36
fat body, larvae L3 wandering		13
fat body, white prepupae		10
fat body, pupae P8		10
carcass, larvae L3 wandering		10
carcass, 1-day adult		24
carcass, 4-day adult		29
carcass, 20-day adult		42
ovary, virgin 4-day female		22
ovary, mated 4-day female		15
testis, mated 4-day male		13
accessory gland, mated 4-day male		16
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		15
central nervous system, larvae L3		5
central nervous system, pupae P8		4
head, virgin 1-day female		14
head, virgin 4-day female		21
head, virgin 20-day female		47
head, mated 1-day female		13
head, mated 4-day female		21
head, mated 20-day female		36
head, mated 1-day male		21
head, mated 4-day male		28
head, mated 20-day male		43
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		35
digestive system, 4-day adult		24
digestive system, 20-day adult		36
fat body, larvae L3 wandering		13
fat body, white prepupae		10
fat body, pupae P8		10
carcass, larvae L3 wandering		10
carcass, 1-day adult		24
carcass, 4-day adult		29
carcass, 20-day adult		42
ovary, virgin 4-day female		22
ovary, mated 4-day female		15
testis, mated 4-day male		13
accessory gland, mated 4-day male		16
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		15
central nervous system, larvae L3		5
central nervous system, pupae P8		4
head, virgin 1-day female		14
head, virgin 4-day female		21
head, virgin 20-day female		(47)
head, mated 1-day female		13
head, mated 4-day female		21
head, mated 20-day female		(36)
head, mated 1-day male		21
head, mated 4-day male		28
head, mated 20-day male		(43)
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		(35)
digestive system, 4-day adult		24
digestive system, 20-day adult		(36)
fat body, larvae L3 wandering		13
fat body, white prepupae		10
fat body, pupae P8		10
carcass, larvae L3 wandering		10
carcass, 1-day adult		24
carcass, 4-day adult		29
carcass, 20-day adult		(42)
ovary, virgin 4-day female		22
ovary, mated 4-day female		15
testis, mated 4-day male		13
accessory gland, mated 4-day male		16
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		15
central nervous system, larvae L3		5
central nervous system, pupae P8		4
head, virgin 1-day female		14
head, virgin 4-day female		21
head, virgin 20-day female		47
head, mated 1-day female		13
head, mated 4-day female		21
head, mated 20-day female		36
head, mated 1-day male		21
head, mated 4-day male		28
head, mated 20-day male		43
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		35
digestive system, 4-day adult		24
digestive system, 20-day adult		36
fat body, larvae L3 wandering		13
fat body, white prepupae		10
fat body, pupae P8		10
carcass, larvae L3 wandering		10
carcass, 1-day adult		24
carcass, 4-day adult		29
carcass, 20-day adult		42
ovary, virgin 4-day female		22
ovary, mated 4-day female		15
testis, mated 4-day male		13
accessory gland, mated 4-day male		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		15
central nervous system, larvae L3		5
central nervous system, pupae P8		4
head, virgin 1-day female		14
head, virgin 4-day female		21
head, virgin 20-day female		47
head, mated 1-day female		13
head, mated 4-day female		21
head, mated 20-day female		36
head, mated 1-day male		21
head, mated 4-day male		28
head, mated 20-day male		43
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		35
digestive system, 4-day adult		24
digestive system, 20-day adult		36
fat body, larvae L3 wandering		13
fat body, white prepupae		10
fat body, pupae P8		10
carcass, larvae L3 wandering		10
carcass, 1-day adult		24
carcass, 4-day adult		29
carcass, 20-day adult		42
ovary, virgin 4-day female		22
ovary, mated 4-day female		15
testis, mated 4-day male		13
accessory gland, mated 4-day male		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the larval period, in stages of adults of both sexes.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		62
embryo 02-04hr		69
embryo 04-06hr		44
embryo 06-08hr		14
embryo 08-10hr		17
embryo 10-12hr		19
embryo 12-14hr		15
embryo 14-16hr		30
embryo 16-18hr		25
embryo 18-20hr		25
embryo 20-22hr		30
embryo 22-24hr		31
larva L1		45
larva L2		64
larva L3 12hr old		73
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		33
larva L3 puffstage 7-9		27
white prepupae new		29
white prepupae 12hr		37
white prepupae 24hr		35
pupae 2d postWPP		33
pupae 3d postWPP		30
pupae 4d postWPP		46
adult male 01day		66
adult male 05day		74
adult male 30day		79
adult female 01day		77
adult female 05day		65
adult female 30day		74
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(62)
embryo 02-04hr		(69)
embryo 04-06hr		(44)
embryo 06-08hr		14
embryo 08-10hr		17
embryo 10-12hr		19
embryo 12-14hr		15
embryo 14-16hr		(30)
embryo 16-18hr		25
embryo 18-20hr		25
embryo 20-22hr		(30)
embryo 22-24hr		(31)
larva L1		(45)
larva L2		(64)
larva L3 12hr old		(73)
larva L3 puffstage 1-2		(55)
larva L3 puffstage 3-6		(33)
larva L3 puffstage 7-9		(27)
white prepupae new		(29)
white prepupae 12hr		(37)
white prepupae 24hr		(35)
pupae 2d postWPP		(33)
pupae 3d postWPP		(30)
pupae 4d postWPP		(46)
adult male 01day		(66)
adult male 05day		(74)
adult male 30day		(79)
adult female 01day		(77)
adult female 05day		(65)
adult female 30day		(74)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		62
embryo 02-04hr		69
embryo 04-06hr		44
embryo 06-08hr		14
embryo 08-10hr		17
embryo 10-12hr		19
embryo 12-14hr		15
embryo 14-16hr		30
embryo 16-18hr		25
embryo 18-20hr		25
embryo 20-22hr		30
embryo 22-24hr		31
larva L1		45
larva L2		64
larva L3 12hr old		73
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		33
larva L3 puffstage 7-9		27
white prepupae new		29
white prepupae 12hr		37
white prepupae 24hr		35
pupae 2d postWPP		33
pupae 3d postWPP		30
pupae 4d postWPP		46
adult male 01day		66
adult male 05day		74
adult male 30day		79
adult female 01day		77
adult female 05day		65
adult female 30day		74
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		62
embryo 02-04hr		69
embryo 04-06hr		44
embryo 06-08hr		14
embryo 08-10hr		17
embryo 10-12hr		19
embryo 12-14hr		15
embryo 14-16hr		30
embryo 16-18hr		25
embryo 18-20hr		25
embryo 20-22hr		30
embryo 22-24hr		31
larva L1		45
larva L2		64
larva L3 12hr old		73
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		33
larva L3 puffstage 7-9		27
white prepupae new		29
white prepupae 12hr		37
white prepupae 24hr		35
pupae 2d postWPP		33
pupae 3d postWPP		30
pupae 4d postWPP		46
adult male 01day		66
adult male 05day		74
adult male 30day		79
adult female 01day		77
adult female 05day		65
adult female 30day		74
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		62
embryo 02-04hr		69
embryo 04-06hr		44
embryo 06-08hr		14
embryo 08-10hr		17
embryo 10-12hr		19
embryo 12-14hr		15
embryo 14-16hr		30
embryo 16-18hr		25
embryo 18-20hr		25
embryo 20-22hr		30
embryo 22-24hr		31
larva L1		45
larva L2		64
larva L3 12hr old		73
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		33
larva L3 puffstage 7-9		27
white prepupae new		29
white prepupae 12hr		37
white prepupae 24hr		35
pupae 2d postWPP		33
pupae 3d postWPP		30
pupae 4d postWPP		46
adult male 01day		66
adult male 05day		74
adult male 30day		79
adult female 01day		77
adult female 05day		65
adult female 30day		74
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(62)
embryo 02-04hr		(69)
embryo 04-06hr		(44)
embryo 06-08hr		14
embryo 08-10hr		17
embryo 10-12hr		19
embryo 12-14hr		15
embryo 14-16hr		30
embryo 16-18hr		25
embryo 18-20hr		25
embryo 20-22hr		30
embryo 22-24hr		31
larva L1		(45)
larva L2		(64)
larva L3 12hr old		(73)
larva L3 puffstage 1-2		(55)
larva L3 puffstage 3-6		(33)
larva L3 puffstage 7-9		27
white prepupae new		29
white prepupae 12hr		(37)
white prepupae 24hr		(35)
pupae 2d postWPP		(33)
pupae 3d postWPP		30
pupae 4d postWPP		(46)
adult male 01day		(66)
adult male 05day		(74)
adult male 30day		(79)
adult female 01day		(77)
adult female 05day		(65)
adult female 30day		(74)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		62
embryo 02-04hr		69
embryo 04-06hr		44
embryo 06-08hr		14
embryo 08-10hr		17
embryo 10-12hr		19
embryo 12-14hr		15
embryo 14-16hr		30
embryo 16-18hr		25
embryo 18-20hr		25
embryo 20-22hr		30
embryo 22-24hr		31
larva L1		45
larva L2		64
larva L3 12hr old		73
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		33
larva L3 puffstage 7-9		27
white prepupae new		29
white prepupae 12hr		37
white prepupae 24hr		35
pupae 2d postWPP		33
pupae 3d postWPP		30
pupae 4d postWPP		46
adult male 01day		66
adult male 05day		74
adult male 30day		79
adult female 01day		77
adult female 05day		65
adult female 30day		74
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		62
embryo 02-04hr		69
embryo 04-06hr		44
embryo 06-08hr		14
embryo 08-10hr		17
embryo 10-12hr		19
embryo 12-14hr		15
embryo 14-16hr		30
embryo 16-18hr		25
embryo 18-20hr		25
embryo 20-22hr		30
embryo 22-24hr		31
larva L1		45
larva L2		64
larva L3 12hr old		73
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		33
larva L3 puffstage 7-9		27
white prepupae new		29
white prepupae 12hr		37
white prepupae 24hr		35
pupae 2d postWPP		33
pupae 3d postWPP		30
pupae 4d postWPP		46
adult male 01day		66
adult male 05day		74
adult male 30day		79
adult female 01day		77
adult female 05day		65
adult female 30day		74
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		32
Schneider line 2 Sg4		42
embryonic 1182-4H		21
embryonic GM2		23
embryonic Kc167		14
embryonic S1		17
embryonic S3		20
leg disc CME L1		31
wing disc CME-W2		24
wing disc ML-DmD8		20
wing disc ML-DmD9		42
wing disc ML-DmD16-c3		21
wing disc ML-DmD21		24
wing disc ML-DmD32		19
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		58
antennal disc ML-DmD20-c5		51
mixed discs ML-DmD4-c1		26
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		31
tumorous blood cells mbn2		19
ovary fGS/OSS		17
ovary OSC		6
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(32)
Schneider line 2 Sg4		(42)
embryonic 1182-4H		21
embryonic GM2		23
embryonic Kc167		14
embryonic S1		17
embryonic S3		20
leg disc CME L1		(31)
wing disc CME-W2		24
wing disc ML-DmD8		20
wing disc ML-DmD9		(42)
wing disc ML-DmD16-c3		21
wing disc ML-DmD21		24
wing disc ML-DmD32		19
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		(58)
antennal disc ML-DmD20-c5		(51)
mixed discs ML-DmD4-c1		26
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		(31)
tumorous blood cells mbn2		19
ovary fGS/OSS		17
ovary OSC		6
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		32
Schneider line 2 Sg4		42
embryonic 1182-4H		21
embryonic GM2		23
embryonic Kc167		14
embryonic S1		17
embryonic S3		20
leg disc CME L1		31
wing disc CME-W2		24
wing disc ML-DmD8		20
wing disc ML-DmD9		42
wing disc ML-DmD16-c3		21
wing disc ML-DmD21		24
wing disc ML-DmD32		19
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		58
antennal disc ML-DmD20-c5		51
mixed discs ML-DmD4-c1		26
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		31
tumorous blood cells mbn2		19
ovary fGS/OSS		17
ovary OSC		6
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		32
Schneider line 2 Sg4		42
embryonic 1182-4H		21
embryonic GM2		23
embryonic Kc167		14
embryonic S1		17
embryonic S3		20
leg disc CME L1		31
wing disc CME-W2		24
wing disc ML-DmD8		20
wing disc ML-DmD9		42
wing disc ML-DmD16-c3		21
wing disc ML-DmD21		24
wing disc ML-DmD32		19
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		58
antennal disc ML-DmD20-c5		51
mixed discs ML-DmD4-c1		26
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		31
tumorous blood cells mbn2		19
ovary fGS/OSS		17
ovary OSC		6
ovary OSS		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		32
Schneider line 2 Sg4		42
embryonic 1182-4H		21
embryonic GM2		23
embryonic Kc167		14
embryonic S1		17
embryonic S3		20
leg disc CME L1		31
wing disc CME-W2		24
wing disc ML-DmD8		20
wing disc ML-DmD9		42
wing disc ML-DmD16-c3		21
wing disc ML-DmD21		24
wing disc ML-DmD32		19
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		58
antennal disc ML-DmD20-c5		51
mixed discs ML-DmD4-c1		26
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		31
tumorous blood cells mbn2		19
ovary fGS/OSS		17
ovary OSC		6
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		32
Schneider line 2 Sg4		(42)
embryonic 1182-4H		21
embryonic GM2		23
embryonic Kc167		14
embryonic S1		17
embryonic S3		20
leg disc CME L1		31
wing disc CME-W2		24
wing disc ML-DmD8		20
wing disc ML-DmD9		(42)
wing disc ML-DmD16-c3		21
wing disc ML-DmD21		24
wing disc ML-DmD32		19
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		(58)
antennal disc ML-DmD20-c5		(51)
mixed discs ML-DmD4-c1		26
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		31
tumorous blood cells mbn2		19
ovary fGS/OSS		17
ovary OSC		6
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		32
Schneider line 2 Sg4		42
embryonic 1182-4H		21
embryonic GM2		23
embryonic Kc167		14
embryonic S1		17
embryonic S3		20
leg disc CME L1		31
wing disc CME-W2		24
wing disc ML-DmD8		20
wing disc ML-DmD9		42
wing disc ML-DmD16-c3		21
wing disc ML-DmD21		24
wing disc ML-DmD32		19
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		58
antennal disc ML-DmD20-c5		51
mixed discs ML-DmD4-c1		26
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		31
tumorous blood cells mbn2		19
ovary fGS/OSS		17
ovary OSC		6
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		32
Schneider line 2 Sg4		42
embryonic 1182-4H		21
embryonic GM2		23
embryonic Kc167		14
embryonic S1		17
embryonic S3		20
leg disc CME L1		31
wing disc CME-W2		24
wing disc ML-DmD8		20
wing disc ML-DmD9		42
wing disc ML-DmD16-c3		21
wing disc ML-DmD21		24
wing disc ML-DmD32		19
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		58
antennal disc ML-DmD20-c5		51
mixed discs ML-DmD4-c1		26
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		31
tumorous blood cells mbn2		19
ovary fGS/OSS		17
ovary OSC		6
ovary OSS		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		13
cold shock, 4-day adult		8
heat shock, 4-day adult		34
Cadmium 50 mM 6 hrs, larvae L3		36
Cadmium 50 mM 12 hrs, larvae L3		23
Cadmium 50 mM 48 hrs, 4-day adult		27
Cadmium 100 mM 48 hrs, 4-day adult		17
Copper 0.5 mM 12 hrs, larvae L3		17
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		15
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		37
Ethanol 10% 3 hrs, larvae L3		40
Caffeine 1.5 mg/ml 4 hrs, larvae L3		31
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		25
Caffeine 25 mg/ml 48 hrs, 4-day adult		8
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		41
Rotenone 8 μg 12 hrs, larvae L3		54
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		13
cold shock, 4-day adult		8
heat shock, 4-day adult		(34)
Cadmium 50 mM 6 hrs, larvae L3		(36)
Cadmium 50 mM 12 hrs, larvae L3		23
Cadmium 50 mM 48 hrs, 4-day adult		(27)
Cadmium 100 mM 48 hrs, 4-day adult		17
Copper 0.5 mM 12 hrs, larvae L3		17
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		15
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		(31)
Ethanol 5% 3 hrs, larvae L3		(37)
Ethanol 10% 3 hrs, larvae L3		(40)
Caffeine 1.5 mg/ml 4 hrs, larvae L3		(31)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		25
Caffeine 25 mg/ml 48 hrs, 4-day adult		8
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		(31)
Rotenone 2 μg 12 hrs, larvae L3		(41)
Rotenone 8 μg 12 hrs, larvae L3		(54)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		13
cold shock, 4-day adult		8
heat shock, 4-day adult		34
Cadmium 50 mM 6 hrs, larvae L3		36
Cadmium 50 mM 12 hrs, larvae L3		23
Cadmium 50 mM 48 hrs, 4-day adult		27
Cadmium 100 mM 48 hrs, 4-day adult		17
Copper 0.5 mM 12 hrs, larvae L3		17
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		15
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		37
Ethanol 10% 3 hrs, larvae L3		40
Caffeine 1.5 mg/ml 4 hrs, larvae L3		31
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		25
Caffeine 25 mg/ml 48 hrs, 4-day adult		8
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		41
Rotenone 8 μg 12 hrs, larvae L3		54
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		13
cold shock, 4-day adult		8
heat shock, 4-day adult		34
Cadmium 50 mM 6 hrs, larvae L3		36
Cadmium 50 mM 12 hrs, larvae L3		23
Cadmium 50 mM 48 hrs, 4-day adult		27
Cadmium 100 mM 48 hrs, 4-day adult		17
Copper 0.5 mM 12 hrs, larvae L3		17
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		15
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		37
Ethanol 10% 3 hrs, larvae L3		40
Caffeine 1.5 mg/ml 4 hrs, larvae L3		31
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		25
Caffeine 25 mg/ml 48 hrs, 4-day adult		8
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		41
Rotenone 8 μg 12 hrs, larvae L3		54
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		13
cold shock, 4-day adult		8
heat shock, 4-day adult		34
Cadmium 50 mM 6 hrs, larvae L3		36
Cadmium 50 mM 12 hrs, larvae L3		23
Cadmium 50 mM 48 hrs, 4-day adult		27
Cadmium 100 mM 48 hrs, 4-day adult		17
Copper 0.5 mM 12 hrs, larvae L3		17
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		15
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		37
Ethanol 10% 3 hrs, larvae L3		40
Caffeine 1.5 mg/ml 4 hrs, larvae L3		31
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		25
Caffeine 25 mg/ml 48 hrs, 4-day adult		8
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		41
Rotenone 8 μg 12 hrs, larvae L3		54
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		13
cold shock, 4-day adult		8
heat shock, 4-day adult		(34)
Cadmium 50 mM 6 hrs, larvae L3		(36)
Cadmium 50 mM 12 hrs, larvae L3		23
Cadmium 50 mM 48 hrs, 4-day adult		27
Cadmium 100 mM 48 hrs, 4-day adult		17
Copper 0.5 mM 12 hrs, larvae L3		17
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		15
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		(37)
Ethanol 10% 3 hrs, larvae L3		(40)
Caffeine 1.5 mg/ml 4 hrs, larvae L3		31
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		25
Caffeine 25 mg/ml 48 hrs, 4-day adult		8
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		(41)
Rotenone 8 μg 12 hrs, larvae L3		(54)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		13
cold shock, 4-day adult		8
heat shock, 4-day adult		34
Cadmium 50 mM 6 hrs, larvae L3		36
Cadmium 50 mM 12 hrs, larvae L3		23
Cadmium 50 mM 48 hrs, 4-day adult		27
Cadmium 100 mM 48 hrs, 4-day adult		17
Copper 0.5 mM 12 hrs, larvae L3		17
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		15
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		37
Ethanol 10% 3 hrs, larvae L3		40
Caffeine 1.5 mg/ml 4 hrs, larvae L3		31
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		25
Caffeine 25 mg/ml 48 hrs, 4-day adult		8
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		41
Rotenone 8 μg 12 hrs, larvae L3		54
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		13
cold shock, 4-day adult		8
heat shock, 4-day adult		34
Cadmium 50 mM 6 hrs, larvae L3		36
Cadmium 50 mM 12 hrs, larvae L3		23
Cadmium 50 mM 48 hrs, 4-day adult		27
Cadmium 100 mM 48 hrs, 4-day adult		17
Copper 0.5 mM 12 hrs, larvae L3		17
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		15
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		37
Ethanol 10% 3 hrs, larvae L3		40
Caffeine 1.5 mg/ml 4 hrs, larvae L3		31
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		25
Caffeine 25 mg/ml 48 hrs, 4-day adult		8
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		41
Rotenone 8 μg 12 hrs, larvae L3		54
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010)

mE2_34_mRNA_expression_cluster_26

External Data & Images

Linkouts

BDGP expression data

•

IP05441

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0031360

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG31937-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

CG31937^GD808

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of CG31937	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG31937	Mutagen	Stocks	Known lesion
CG31937^GD808	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG31937^NIG.17711R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
CG31937^NIG.31937R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(2L)Exel6005

(Ryder, 2004.4.26)

Df(2L)Exel7007

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD808}

P{NIG.17711R}

P{NIG.31937R}

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 2 terms )

Molecular Function

CV term

Evidence

References

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

inferred from sequence or structural similarity with EMBL:AJ000671

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

metabolic process

inferred from electronic annotation with InterPro:IPR002198

(FlyBase Curators et al., 2004-)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

protein-protein

Interacting group

Assay

References

CG31937 - Uba1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mintseris et al., 2009.11.23)

CG31937 - tyn

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mintseris et al., 2009.11.23)

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG31937 allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0031360

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

326177

Orthologs

OrthoDB Orthologs (61) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6D53HT

Dipteran inclusive ortholog search

EOG6P5KJZ

Insect inclusive ortholog search

EOG673NN3

Arthropod inclusive ortholog search

EOG6WDBTK

Metazoa inclusive ortholog search

EOG6X9MB8

Orthologs in Drosophila Species (EOG6D53HT)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA16579

Drosophila persimilis

Dper\GL19653

Drosophila willistoni

Dwil\GK18350

Drosophila willistoni

Dwil\GK20197

Drosophila virilis

Dvir\GJ22769

Drosophila grimshawi

Dgri\GH25201

Orthologs in non-Drosophila Dipterans (EOG6P5KJZ)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL003961

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ011026

Orthologs in non-Dipteran Insects (EOG673NN3)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB44894

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG001394

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH25781

Atta cephalotes

Leafcutter ant

Acep\ACEP20240

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO12491

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO16918

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO20812

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL21077

Linepithema humile

Argentine ant

Lhum\LH22620

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB18258

Solenopsis invicta

Red fire ant

Sinv\SINV17965

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001909

Pediculus humanus

Human body louse

Phum\PHUM490940

Tribolium castaneum

Red flour beetle

Tcas\TC003649

Orthologs in non-Insect Arthropods (EOG6WDBTK)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\TEX11

Daphnia pulex

Water flea

Dpux\JGI_V11_187647

Ixodes scapularis

Deer tick

Isca\ISCW005749

Ixodes scapularis

Deer tick

Isca\ISCW002401

Ixodes scapularis

Deer tick

Isca\ISCW015035

Orthologs in non-Arthropod Metazoa (EOG6X9MB8)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\F28H7.2

Caenorhabditis elegans

Nematode

Cele\T25G12.13

Caenorhabditis elegans

Nematode

Cele\C33E10.10

Caenorhabditis elegans

Nematode

Cele\dhs-30

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_005527gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_017219gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_027531gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_011733gn

Danio rerio

Zebrafish

Drer\dhrs7

Danio rerio

Zebrafish

Drer\dhrs7b

Danio rerio

Zebrafish

Drer\dhrs7ca

Danio rerio

Zebrafish

Drer\zgc:101633

Xenopus tropicalis

Western clawed frog

Xtro\dhrs7c

Xenopus tropicalis

Western clawed frog

Xtro\dhrs7

Xenopus tropicalis

Western clawed frog

Xtro\dhrs7b

Gallus gallus

Domestic chicken

Ggal\DHRS7

Gallus gallus

Domestic chicken

Ggal\DHRS7C

Gallus gallus

Domestic chicken

Ggal\DHRS7B

Mus musculus

House mouse

Mmus\ENSMUSG00000033044

Mus musculus

House mouse

Mmus\ENSMUSG00000042569

Mus musculus

House mouse

Mmus\Dhrs7

Rattus norvegicus

Norway rat

Rnor\ENSRNOG00000005360

Rattus norvegicus

Norway rat

Rnor\Dhrs7

Rattus norvegicus

Norway rat

Rnor\RGD1565002

Rattus norvegicus

Norway rat

Rnor\Dhrs7c

Homo sapiens

Human

Hsap\DHRS7C

Homo sapiens

Human

Hsap\DHRS7B

Homo sapiens

Human

Hsap\DHRS7

Human Orthologs (3)

Gene

OMIM

HGNC

Hsap\DHRS7C

Hsap\DHRS7B

Hsap\DHRS7

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA16579

Drosophila persimilis

Dper\GL19653

Drosophila willistoni

Dwil\GK18350

Drosophila virilis

Dvir\GJ22769

Drosophila mojavensis

Dmoj\GI17270

Drosophila grimshawi

Dgri\GH25201

Stocks & Reagents

Stocks Listed in FlyBase ( 1 )

VDRC

v3449

w¹¹¹⁸; P{GD808}v3449

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 28 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

FI07842

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0031360

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

326177

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: CG17711 CG31937

(FlyBase, 1996-)

Additional comments

Source for merge of CG17711 CG31937 was a shared cDNA (date:030728).

(FlyBase, 1996-)

Other Comments

Annotation CG17711 renamed CG31937 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_134772

RefSeq (Proteins)

•

NP_608616

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

326177

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Short-chain dehydrogenase/reductase SDR (IPR002198)

Glucose/ribitol dehydrogenase (IPR002347)

NAD(P)-binding domain (IPR016040)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

IP05441

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0031360

DRSC - Results from RNAi screens.

•

FBgn0031360

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0031360

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG31937-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0031360

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

326177

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

326177

modMine - Data generated by the modENCODE project.

•

FBgn0031360

Synonyms & Secondary IDs ( 3 )

Reported As

Symbol Synonym

CG17711

(Collier et al., 2005, )

CG31937

(Japanese National Institute of Genetics, 2012.5.21)

CT39259

(Ceriani et al., 2002)

Name Synonym

Secondary FlyBase IDs

FBgn0051937

References ( 15 )

Research paper

Collier et al., 2005, Genetics 169(4): 2035--2045: The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis. [FBrf0187636]
Ceriani et al., 2002, J. Neurosci. 22(21): 9305--9319: Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. [FBrf0152147]

Supplementary material

The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]

Personal communication to FlyBase

Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project: DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

FlyBase analysis

FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome.: Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886]
FlyBase, 1996-, FlyBase inference based on genome sequence analysis.: FlyBase inference based on genome sequence analysis. [FBrf0104946]
FlyBase, 1992-, FlyBase curation.: FlyBase curation. [FBrf0105495]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]

Website

Fisher et al., 2012, BDGP insitu homepage: BDGP insitu homepage [FBrf0219073]

Curated genome annotation

FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.]: [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]