FB2020_03, released Jun 16, 2020

Gene: Dmel\erm

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General Information
Symbol
Dmel\erm
Species
D. melanogaster
Name
earmuff
Annotation Symbol
CG31670
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031375
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
earmuff (erm) encodes a transcriptional repressor that functions as a cell fate regulator by restricting responses to various signaling mechanisms including the Notch pathway during neurogenesis. It contributes to cell fate decisions of the type II neural stem cell in the fly larval brain. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

dFezf, dfezl

Key Links
Genomic Location
Cytogenetic map
22B6-22B8
Sequence location
2L:1,950,239..1,970,362 [-]
Recombination map

2-3

RefSeq locus
NT_033779 REGION:1950239..1970362
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
protein binding
inferred from physical interaction with UniProtKB:P25439
(assigned by UniProt )
(Koe et al., 2014)
inferred from physical interaction with UniProtKB:Q24090
(assigned by UniProt )
(Koe et al., 2014)
inferred from physical interaction with UniProtKB:Q7KTS4
(assigned by UniProt )
(Koe et al., 2014)
inferred from physical interaction with UniProtKB:Q9VYG2
(assigned by UniProt )
(Koe et al., 2014)
sequence-specific DNA binding
inferred from direct assay
(assigned by UniProt )
(Janssens et al., 2017)
transcription regulatory region sequence-specific DNA binding
inferred from direct assay
(assigned by UniProt )
(Janssens et al., 2017)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (14 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
axon target recognition
inferred from mutant phenotype
(assigned by UniProt )
(Peng et al., 2018)
axonogenesis involved in innervation
inferred from mutant phenotype
(assigned by UniProt )
(Peng et al., 2018)
cell dedifferentiation
inferred from genetic interaction with UniProtKB:P07207
(assigned by UniProt )
(Weng et al., 2010)
inferred from genetic interaction with UniProtKB:P29617
(assigned by UniProt )
(Xie et al., 2016)
inferred from genetic interaction with UniProtKB:P25439
(assigned by UniProt )
(Koe et al., 2014)
inferred from genetic interaction with UniProtKB:Q24090
(assigned by UniProt )
(Koe et al., 2014)
inferred from genetic interaction with UniProtKB:Q9VNC2
(assigned by UniProt )
(Koe et al., 2014)
negative regulation of gene expression
inferred from mutant phenotype
(assigned by UniProt )
(Li et al., 2016)
inferred from direct assay
(assigned by UniProt )
(Janssens et al., 2017)
negative regulation of neuroblast proliferation
inferred from genetic interaction with UniProtKB:P25439
(assigned by UniProt )
(Koe et al., 2014)
inferred from genetic interaction with UniProtKB:Q24090
(assigned by UniProt )
(Koe et al., 2014)
inferred from genetic interaction with UniProtKB:Q9VNC2
(assigned by UniProt )
(Koe et al., 2014)
inferred from mutant phenotype
(Janssens et al., 2014)
negative regulation of transcription, DNA-templated
inferred from mutant phenotype
(Janssens et al., 2014)
photoreceptor cell axon guidance
inferred from mutant phenotype
(assigned by UniProt )
(Peng et al., 2018)
positive regulation of gene expression
inferred from mutant phenotype
(assigned by UniProt )
(Peng et al., 2018)
positive regulation of netrin-activated signaling pathway
inferred from mutant phenotype
(assigned by UniProt )
(Peng et al., 2018)
positive regulation of neuron differentiation
inferred from genetic interaction with FLYBASE:IntS8; FB:FBgn0025830
(Zhang et al., 2019)
regulation of neuroblast proliferation
inferred from genetic interaction with UniProtKB:P51023
(assigned by UniProt )
(Li et al., 2017, Li et al., 2016)
inferred from mutant phenotype
(assigned by UniProt )
(Li et al., 2016)
inferred from genetic interaction with UniProtKB:P07207
(assigned by UniProt )
(Li et al., 2016)
inferred from genetic interaction with UniProtKB:P07207,UniProtKB:P51023
(assigned by UniProt )
(Li et al., 2016)
inferred from genetic interaction with UniProtKB:P29617
(assigned by UniProt )
(Weng et al., 2010)
inferred from genetic interaction with UniProtKB:M9PF84
(assigned by UniProt )
(Janssens et al., 2014)
inferred from genetic interaction with UniProtKB:Q01070
(assigned by UniProt )
(Janssens et al., 2014)
inferred from genetic interaction with UniProtKB:Q26263
(assigned by UniProt )
(Janssens et al., 2014)
regulation of neurogenesis
inferred from mutant phenotype
(Weng et al., 2010)
stem cell population maintenance
inferred from mutant phenotype
(Weng et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
regulation of gene expression
inferred from biological aspect of ancestor with PANTHER:PTN002811836
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
axonal growth cone
inferred from direct assay
(assigned by UniProt )
(Peng et al., 2018)
neuronal cell body
inferred from direct assay
(assigned by UniProt )
(Peng et al., 2018)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002811836
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the krueppel C2H2-type zinc-finger protein family. (Q9VQ56)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Protein Function (UniProtKB)
Zinc-finger transcriptional repressor (PubMed:24550111, PubMed:24618901, PubMed:28245922). In larval brain, involved in the maintenance of cell fate of intermediate neural progenitors (INPs) that derive from type II neuroblasts (PubMed:20152183, PubMed:24618901, PubMed:27151950, PubMed:27510969, PubMed:28245922, PubMed:28899667). Restricts INP developmental potential and dedifferentiation by interacting with HDAC3 and the chromatin remodeling Brahma-associated protein (BAP) complex (PubMed:24618901, PubMed:24550111, PubMed:27151950, PubMed:28899667, PubMed:28245922). Restricts INP proliferation by regulating neuroblast specific factors such as prospero, pnt and grh, and by antagonizing the function of self-renewal factors, such as klu, dpn and E(spl)mgamma-HLH (PubMed:20152183, PubMed:24550111, PubMed:28899667). In the optic lobe, essential for coordinating the innervation/ targeting of the L3 and R8 axons to the M3 layer of the medulla (PubMed:29513217). Early in medulla development, functions in parallel to CadN and Sema1a pathways to promote targeting of the L3 growth cones to the proximal domain of the outer medulla possibly by controlling the expression of various cell surface genes such as dpr1 and dpr17 which function in L3 growth cone targeting (PubMed:29513217). Then once L3 growth cones segregate into the developing M3 layer, it activates the expression of netrins NetA and NetB which act locally to promote the attachment of R8 growth cones within the M3 layer (PubMed:29513217).
(UniProt, Q9VQ56)
Summary (Interactive Fly)

zinc finger transcription factor - functions cell-autonomously to maintain the restricted developmental potential of the intermediate neural progenitors generated by type II neuroblasts in Drosophila larval brains

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\erm or the JBrowse view of Dmel\erm for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 6.01

Gene model reviewed during 5.47

Gene model reviewed during 5.44

gene_with_stop_codon_read_through ; SO:0000697

Double stop-codon suppression (UGA, UGA) postulated; FBrf0216884.

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
erm-RA
FBtr0077870
NM_134787
2881
611
erm-RB
FBtr0330200
NM_001272960
3051
603
erm-RC
FBtr0330201
NM_001272961
2881
654
erm-RD
FBtr0330202
NM_001272962
2881
698
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
erm-PA
FBpp0077539
66.4
611
8.92
NP_608631
AAF51325
erm-PB
FBpp0303233
65.5
603
8.85
NP_001259889
AGB92426
erm-PC
FBpp0303234
70.9
654
8.84
NP_001259890
AGB92427
erm-PD
FBpp0303235
75.0
698
8.65
NP_001259891
AGB92428
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Found in a probable chromatin remodeling Brahma-associated proteins (BAP) complex composed of at least brm, Bap60, Snr1 and erm. Within the complex, interacts (via N-terminus) with Bap60 and HDAC3.

(UniProt, Q9VQ56)
Domain

The second, third and fourth zinc finger domains are necessary for repressing gene transcription.

(UniProt, Q9VQ56)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\erm using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
embryonic stage 4 -- 5
procephalic neurogenic region
(Irimia et al., 2010)
embryonic stage
embryonic brain | restricted
(Irimia et al., 2010)
Additional Descriptive Data

erm is expressed as a dorsal and lateral stripe in blastoderm embryos. The lateral ends of this stripe widen, making the pattern resemble earmuffs. In early germband extension embryos, the stripe is split at the dorsal midline generating bilaterally symmetrical domains. In later embyronic stages, erm-expressing cells delaminate and cluster to form part of the brain hemispheres. The expression domain of mirr abuts the erm expression domain in a complementary pattern.

(Irimia et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
axonal growth cone
inferred from direct assay
(assigned by UniProt )
(Peng et al., 2018)
neuronal cell body
inferred from direct assay
(assigned by UniProt )
(Peng et al., 2018)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\erm in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of erm
Transgenic constructs containing regulatory region of erm
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | male limited, with Scer\GAL4Bx-MS1096
viable
Sterility
Allele
fertile
Other Phenotypes
Allele
increased cell number | larval stage, with Scer\GAL4wor.PU, Scer\GAL80ase.PN
increased occurrence of cell division | embryonic stage, with Scer\GAL4elav-C155
neuroanatomy defective
neuroanatomy defective, with Df(2L)erm2, Scer\GAL4GMR9D11, ermzf.VP16.UAS/erm1
neuroanatomy defective, with Scer\GAL4wor.PA
neuroanatomy defective (with erm1), with Df(2L)erm2
neuroanatomy defective (with erm1), with Df(2L)erm2, Scer\GAL4GMR9D11, ermTag:FLAG
neuroanatomy defective (with ermTag:FLAG), with Df(2L)erm2
neuroanatomy defective (with ermzf.VP16.UAS), with Df(2L)erm2, Scer\GAL4GMR9D11, ermTag:FLAG
neuroanatomy defective | larval stage, with Scer\GAL4wor.PU, Scer\GAL80ase.PN
neuroanatomy defective | larval stage | somatic clone
neuroanatomy defective | somatic clone
neuroanatomy defective | somatic clone (with Df(2L)erm2)
neuroanatomy defective | somatic clone (with erm1), with Df(2L)erm2, Scer\GAL4GMR9D11
neuroanatomy defective | somatic clone (with ermzf.VP16.UAS), with Df(2L)erm2, Scer\GAL4GMR9D11
visible | female limited, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
ganglion mother cell | embryonic stage, with Scer\GAL4elav-C155
larval neuroblast
larval neuroblast, with Scer\GAL4wor.PA
larval neuroblast | ectopic | somatic clone | supernumerary
larval neuroblast | ectopic | supernumerary
larval neuroblast | larval stage (with Df(2L)erm2)
neuroblast | embryonic stage, with Scer\GAL4elav-C155
type II neuroblast | larval stage, with Scer\GAL4wor.PU, Scer\GAL80ase.PN
type II neuroblast | larval stage | somatic clone | supernumerary
type II neuroblast | somatic clone | supernumerary (with Df(2L)erm2)
type II neuroblast | somatic clone | supernumerary (with erm1), with Df(2L)erm2, Scer\GAL4GMR9D11
type II neuroblast | somatic clone | supernumerary (with ermzf.VP16.UAS), with Df(2L)erm2, Scer\GAL4GMR9D11
type II neuroblast | supernumerary, with Df(2L)erm2, Scer\GAL4GMR9D11, ermzf.VP16.UAS/erm1
type II neuroblast | supernumerary (with erm1), with Df(2L)erm2
type II neuroblast | supernumerary (with erm1), with Df(2L)erm2, Scer\GAL4GMR9D11, ermTag:FLAG
type II neuroblast | supernumerary (with ermTag:FLAG), with Df(2L)erm2
type II neuroblast | supernumerary (with ermzf.VP16.UAS), with Df(2L)erm2, Scer\GAL4GMR9D11, ermTag:FLAG
type II neuroblast | supernumerary | third instar larval stage, with Scer\GAL4wor.PA
type II neuroblast | third instar larval stage, with Scer\GAL4wor.PA
ventral nerve cord | embryonic stage, with Scer\GAL4elav-C155
wing | female limited, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (34)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\FEZF1
9 of 15
Yes
Yes
Hsap\FEZF2
9 of 15
Yes
Yes
Hsap\BCL6B
1 of 15
No
Yes
Hsap\GFI1B
1 of 15
No
No
1  
Hsap\LOC145783
1 of 15
No
Yes
Hsap\NACC1
1 of 15
No
No
Hsap\NACC2
1 of 15
No
Yes
Hsap\OSR1
1 of 15
No
No
Hsap\OSR2
1 of 15
No
No
Hsap\PRDM1
1 of 15
No
No
Hsap\PRDM12
1 of 15
No
Yes
5  
Hsap\ZBTB3
1 of 15
No
Yes
Hsap\ZBTB6
1 of 15
No
Yes
Hsap\ZBTB7B
1 of 15
No
Yes
Hsap\ZBTB12
1 of 15
No
No
Hsap\ZBTB14
1 of 15
No
Yes
Hsap\ZBTB21
1 of 15
No
Yes
Hsap\ZBTB25
1 of 15
No
Yes
Hsap\ZBTB26
1 of 15
No
Yes
Hsap\ZBTB33
1 of 15
No
Yes
Hsap\ZBTB49
1 of 15
No
Yes
Hsap\ZNF280A
1 of 15
No
No
Hsap\ZNF280B
1 of 15
No
No
Hsap\ZNF280C
1 of 15
No
No
Hsap\ZNF280D
1 of 15
No
No
Hsap\ZNF444
1 of 15
No
Yes
Hsap\ZNF467
1 of 15
No
No
Hsap\ZNF500
1 of 15
No
No
Hsap\ZNF524
1 of 15
No
Yes
Hsap\ZNF580
1 of 15
No
Yes
Hsap\ZNF581
1 of 15
No
Yes
Hsap\ZNF683
1 of 15
No
No
Hsap\ZNF764
1 of 15
No
Yes
Hsap\ZSCAN5C
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (33)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Fezf2
9 of 15
Yes
Yes
1  
Mmus\Fezf1
8 of 15
No
Yes
1  
Mmus\2810021J22Rik
1 of 15
No
No
Mmus\9130019O22Rik
1 of 15
No
Yes
Mmus\Bcl6b
1 of 15
No
No
Mmus\Gfi1b
1 of 15
No
No
Mmus\Nacc1
1 of 15
No
No
Mmus\Nacc2
1 of 15
No
Yes
Mmus\Osr1
1 of 15
No
No
1  
Mmus\Osr2
1 of 15
No
No
Mmus\Prdm12
1 of 15
No
Yes
Mmus\Zbtb3
1 of 15
No
Yes
Mmus\Zbtb6
1 of 15
No
Yes
Mmus\Zbtb7b
1 of 15
No
Yes
Mmus\Zbtb12
1 of 15
No
Yes
Mmus\Zbtb14
1 of 15
No
Yes
Mmus\Zbtb21
1 of 15
No
Yes
Mmus\Zbtb25
1 of 15
No
No
Mmus\Zbtb26
1 of 15
No
Yes
Mmus\Zbtb33
1 of 15
No
Yes
Mmus\Zbtb49
1 of 15
No
Yes
Mmus\Zfp9
1 of 15
No
No
Mmus\Zfp280b
1 of 15
No
No
Mmus\Zfp280c
1 of 15
No
No
Mmus\Zfp280d
1 of 15
No
No
Mmus\Zfp444
1 of 15
No
Yes
Mmus\Zfp446
1 of 15
No
Yes
Mmus\Zfp524
1 of 15
No
Yes
Mmus\Zfp580
1 of 15
No
Yes
Mmus\Zfp991
1 of 15
No
No
Mmus\Zfp992
1 of 15
No
No
Mmus\Zic5
1 of 15
No
No
Mmus\Zscan5b
1 of 15
No
No
Rattus norvegicus (Norway rat) (31)
Rnor\Fezf1
8 of 13
Yes
Yes
Rnor\Fezf2
7 of 13
No
Yes
Rnor\Bcl6b
1 of 13
No
Yes
Rnor\Gfi1b
1 of 13
No
No
Rnor\LOC100909461
1 of 13
No
Yes
Rnor\LOC100909869
1 of 13
No
Yes
Rnor\LOC100910807
1 of 13
No
Yes
Rnor\LOC102553866
1 of 13
No
Yes
Rnor\LOC103690173
1 of 13
No
No
Rnor\Nacc1
1 of 13
No
Yes
Rnor\Nacc2
1 of 13
No
Yes
Rnor\Osr1
1 of 13
No
No
Rnor\Osr2
1 of 13
No
No
Rnor\Prdm12
1 of 13
No
Yes
Rnor\Zbtb3
1 of 13
No
Yes
Rnor\Zbtb6
1 of 13
No
Yes
Rnor\Zbtb7b
1 of 13
No
Yes
Rnor\Zbtb12
1 of 13
No
Yes
Rnor\Zbtb21
1 of 13
No
Yes
Rnor\Zbtb25
1 of 13
No
Yes
Rnor\Zbtb26
1 of 13
No
Yes
Rnor\Zbtb33
1 of 13
No
Yes
Rnor\Zbtb49
1 of 13
No
Yes
Rnor\Zfp161
1 of 13
No
Yes
Rnor\Zfp212
1 of 13
No
Yes
Rnor\Zfp280b
1 of 13
No
No
Rnor\Zfp280c
1 of 13
No
No
Rnor\Zfp280d
1 of 13
No
No
Rnor\Zfp524
1 of 13
No
Yes
Rnor\Zfp580
1 of 13
No
Yes
Rnor\Zfp648
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (19)
Xtro\fezf1
9 of 12
Yes
Yes
Xtro\fezf2
7 of 12
No
Yes
Xtro\gfi1b
1 of 12
No
No
Xtro\hic1
1 of 12
No
Yes
Xtro\nacc1
1 of 12
No
Yes
Xtro\nacc2
1 of 12
No
Yes
Xtro\osr1
1 of 12
No
No
Xtro\osr2
1 of 12
No
No
Xtro\sp5l
1 of 12
No
No
Xtro\zbtb3
1 of 12
No
Yes
Xtro\zbtb6
1 of 12
No
Yes
Xtro\zbtb7b
1 of 12
No
Yes
Xtro\zbtb14
1 of 12
No
Yes
Xtro\zbtb25
1 of 12
No
Yes
Xtro\zbtb26
1 of 12
No
Yes
Xtro\zbtb33
1 of 12
No
Yes
Xtro\zbtb49
1 of 12
No
Yes
Xtro\znf33b
1 of 12
No
Yes
Xtro\znf630
1 of 12
No
No
Danio rerio (Zebrafish) (29)
Drer\fezf1
9 of 15
Yes
Yes
Drer\fezf2
8 of 15
No
Yes
Drer\zbtb49
2 of 15
No
Yes
Drer\bcl6b
1 of 15
No
Yes
Drer\egr2b
1 of 15
No
No
Drer\gfi1aa
1 of 15
No
No
Drer\gfi1b
1 of 15
No
No
Drer\LOC103910274
1 of 15
No
Yes
Drer\nacc1b
1 of 15
No
Yes
Drer\osr1
1 of 15
No
No
Drer\osr2
1 of 15
No
No
Drer\prdm12b
1 of 15
No
Yes
Drer\si:cabz01054396.2
1 of 15
No
No
Drer\si:ch211-236k19.4
1 of 15
No
Yes
Drer\si:dkey-33c14.6
1 of 15
No
Yes
Drer\sp3b
1 of 15
No
No
Drer\zbtb3
1 of 15
No
Yes
Drer\zbtb7b
1 of 15
No
Yes
Drer\zbtb12.1
1 of 15
No
Yes
Drer\zbtb12.2
1 of 15
No
Yes
Drer\zbtb14
1 of 15
No
Yes
Drer\zbtb21
1 of 15
No
Yes
Drer\zbtb25
1 of 15
No
Yes
Drer\zbtb33
1 of 15
No
Yes
Drer\zbtb38
1 of 15
No
Yes
Drer\zgc:113377
1 of 15
No
Yes
Drer\zgc:136308
1 of 15
No
Yes
Drer\znf296
1 of 15
No
No
Drer\znf668
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\fezf-1
10 of 15
Yes
Yes
Cele\eor-1
1 of 15
No
No
Cele\klu-1
1 of 15
No
No
Cele\Y111B2A.10
1 of 15
No
No
Cele\zfp-2
1 of 15
No
No
Cele\ZK686.5
1 of 15
No
Yes
Cele\ztf-6
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (7)
Atha\AT1G14580
1 of 9
Yes
Yes
Atha\AT5G22890
1 of 9
Yes
Yes
Atha\IDD4
1 of 9
Yes
Yes
Atha\IDD11
1 of 9
Yes
Yes
Atha\NUC
1 of 9
Yes
Yes
Atha\STOP1
1 of 9
Yes
Yes
Atha\TFIIIA
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\AZF1
3 of 15
Yes
Yes
Scer\ADR1
1 of 15
No
Yes
Scer\PZF1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\prz1
1 of 12
Yes
No
Spom\sfc2
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919087W )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000789
Drosophila simulans
Dsim\GD22883
Drosophila sechellia
Dsec\GM16579
Drosophila erecta
Dere\GG24566
Drosophila yakuba
Dyak\GE15291
Drosophila ananassae
Dana\GF19706
Drosophila pseudoobscura pseudoobscura
Dpse\GA16381
Drosophila persimilis
Dper\GL18461
Drosophila willistoni
Dwil\GK24816
Drosophila virilis
Dvir\GJ19651
Drosophila mojavensis
Dmoj\GI13715
Drosophila grimshawi
Dgri\GH10862
Drosophila grimshawi
Dgri\GH25019
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507ST )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17008307
Glossina morsitans
Tsetse fly
Gmor\GMOY004045
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05249
Mayetiola destructor
Hessian fly
Mdes\Mdes011831
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007233
Anopheles gambiae
Malaria mosquito
Agam\AGAP009286
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012530
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0971 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004593
Danaus plexippus
Monarch butterfly
Dple\DPOGS200072-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004320
Apis florea
Little honeybee
Aflo\5092946484
Apis mellifera
Western honey bee
Amel\GB40147
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20872
Bombus terrestris
Buff-tailed bumblebee
Bter\15205138
Linepithema humile
Argentine ant
Lhum\LH13918
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0017e9
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012421
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09264
Tribolium castaneum
Red flour beetle
Tcas\TC004673
Pediculus humanus
Human body louse
Phum\PHUM527180
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004681
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08301
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0939 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013549
Ixodes scapularis
Black-legged tick
Isca\ISCW016275
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68317.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g01250
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g01260
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_40822
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0ISJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Z133
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Z133_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004152
Gallus gallus
Domestic chicken
Ggal\FEZF1
Gallus gallus
Domestic chicken
Ggal\FEZF2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (18)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG1602
1 of 10
CG4374
1 of 10
CG7691
1 of 10
CG10348
1 of 10
CG11247
1 of 10
CG12071
1 of 10
CG17328
1 of 10
CG17806
1 of 10
CG32767
1 of 10
ham
1 of 10
hb
1 of 10
ich
1 of 10
MESR4
1 of 10
Prdm13
1 of 10
sens-2
1 of 10
sens
1 of 10
sqz
1 of 10
zld
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FEZF1; FEZ family zinc finger 1
    9 of 15
    613301
    FEZF2; FEZ family zinc finger 2
    9 of 15
    607414
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        erm
        enhanceable
        brm
        (Janssens et al., 2014)
        erm
        suppressible
        Dcr-2|N
        (Weng et al., 2010)
        erm|tll
        suppressible
        Doc2|otp
        (Curt et al., 2019)
        erm
        enhanceable
        Doc2|otp|tll
        (Curt et al., 2019)
        erm
        suppressible
        dpn
        (Janssens et al., 2014)
        erm
        enhanceable
        dpn
        (Janssens et al., 2014)
        erm
        enhanceable
        E(spl)mγ-HLH
        (Janssens et al., 2014)
        erm
        suppressible
        klu
        (Janssens et al., 2014)
        erm
        enhanceable
        klu
        (Janssens et al., 2014)
        erm
        suppressible
        pros
        (Weng et al., 2010)
        erm
        suppressible
        trx
        (Komori et al., 2014)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        brat
        suppressible
        erm
        (Janssens et al., 2014)
        brat
        enhanceable
        erm
        (Janssens et al., 2014)
        Doc2
        enhanceable
        erm|otp|tll
        (Curt et al., 2019)
        dpn
        suppressible
        erm
        (Janssens et al., 2014)
        dpn
        enhanceable
        erm
        (Janssens et al., 2014)
        E(spl)mγ-HLH
        suppressible
        erm
        (Janssens et al., 2014)
        IntS8
        suppressible
        erm
        (Zhang et al., 2019)
        IntS8
        enhanceable
        erm
        (Zhang et al., 2019)
        N
        suppressible
        erm
        (Weng et al., 2010)
        numb
        enhanceable
        erm
        (Janssens et al., 2014)
        otp
        enhanceable
        Doc2|erm|tll
        (Curt et al., 2019)
        pnt
        suppressible
        erm
        (Xie et al., 2016)
        tll
        enhanceable
        erm
        (Curt et al., 2019)
        tll
        enhanceable
        Doc2|erm|otp
        (Curt et al., 2019)
        External Data
        Subunit Structure (UniProtKB)
        Found in a probable chromatin remodeling Brahma-associated proteins (BAP) complex composed of at least brm, Bap60, Snr1 and erm. Within the complex, interacts (via N-terminus) with Bap60 and HDAC3.
        (UniProt, Q9VQ56 )
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map

        2-3

        Cytogenetic map
        22B6-22B8
        Sequence location
        2L:1,950,239..1,970,362 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        22B6-22B8
        Limits computationally determined from genome sequence between P{lacW}CG17646k11021 and P{EP}EP366
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-3

        (FlyBase, 2016)

        2-3.7

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (11)
        Genomic Clones (19)
        cDNA Clones (4)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Janssens et al., 2014)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: erm CG31670

          (Weng et al., 2010)
          Source for database merge of

          Source for merge of: CG7312 CG31670

          (FlyBase, 1996-)
          Additional comments

          Source for merge of CG7312 CG31670 was a shared cDNA ( date:030728 ).

          (FlyBase, 1996-)
          Other Comments

          Duplicate transcripts identified and eliminated during the migration of annotations from the release 5 genome assembly to the release 6 assembly.

          (FlyBase Genome Annotators, 2014)

          Annotation CG7312 renamed CG31670 in release 3 of the genome annotation.

          (FlyBase Genome Annotators, 2002-2003)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 42 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Synonyms and Secondary IDs (8)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (87)