Gene model reviewed during 5.44
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR2 subcomplex which is likely composed of mio, Nup44A/Seh1, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Interacts with Wdr24 (PubMed:27166823). Interacts with nucleoporin Nup44A/Seh1 (PubMed:21521741).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mio using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\mio in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: mio CG7074 CG15384
Source for merge of: CG7074 CG15384
mio is required for the maintenance of the meiotic cycle during oogenesis, and for oocyte differentiation.
Homozygous females are sterile. All 16 cells in the germline cyst develop as polyploid nurse cells. An oocyte is specified and enters meiosis in these flies, but meiosis is not maintained and the oocyte eventually enters the endocycle and develops with the characteristics of a nurse cell. Microtubule-based transport is not grossly abnormal.