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Gene Dmel\p16-ARC

General Information
Symbol	Dmel\p16-ARC	Species	D. melanogaster
Name	p16-ARC	Annotation symbol	CG9881
Feature type	protein_coding_gene	FlyBase ID	FBgn0031437
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	23A1-23A1	Sequence location	2L:2,580,291..2,581,114 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene p16-ARC is referred to in FlyBase by the symbol Dmel\p16-ARC (CG9881, FBgn0031437). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence that it is involved in the biological process: cell morphogenesis; phagocytosis, engulfment. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: ARP2/3 complex 16kDa subunit (p16-Arc). Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634204_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of p16-ARC. Gene sequence location is 2L:2580291..2581114.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN29147 HFA00730 References D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478 Controlled Vocabulary Terms cell morphogenesis
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 23A1-23A1   Limits computationally determined from genome sequence between P{PZ}dpp10638 and P{EP}EP832
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\p16-ARC for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) p16-ARC-RA FBtr0077694  NM_134849   762   151
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein p16-ARC-PA   FBpp0077378   16.7   151   4.79     NP_608693   AAF51237
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ARP2/3 complex 16kDa subunit (p16-Arc) (IPR006789)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA978978   AE014134 AAF51237   AI295159   AI518403   AI944798   AY089678 AAL90416   AY113257   BE975163   BF501378   BI352711   BI617798   BI622543   BI630044   BP541309   BP546043   BP546404   BP547173   BP549887   BP549888   BP551153   BP551154   BP553104   BP553105   BP553722   BP553723   BP556475   BP556476   CO301925   EC222980   EC229357   GH945778   GH946166   GH946703   GH958056   GH962891   GH965839   GH970557   GH975164   GH977362   GH978883   GH983879
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VQD8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031437    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031437 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031437 expression level Developmental Stage   Expression Level embryo 00-02hr    5771 embryo 02-04hr    6269 embryo 04-06hr    8548 embryo 06-08hr    7052 embryo 08-10hr    6242 embryo 10-12hr    5513 embryo 12-14hr    3668 embryo 14-16hr    3818 embryo 16-18hr    3120 embryo 18-20hr    3090 embryo 20-22hr    2919 embryo 22-24hr    2959 larva L1    4090 larva L2    4403 larva L3 12hr old    3153 larva L3 puffstage 1-2    4876 larva L3 puffstage 3-6    5447 larva L3 puffstage 7-9    6133 white prepupae new    6374 white prepupae 12hr    5133 white prepupae 24hr    6349 pupae 2d postWPP    5273 pupae 3d postWPP    3326 pupae 4d postWPP    3485 adult male 01day    3274 adult male 05day    3996 adult male 30day    4527 adult female 01day    4322 adult female 05day    4576 adult female 30day    4786 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5771) embryo 02-04hr  (6269) embryo 04-06hr  (8548) embryo 06-08hr  (7052) embryo 08-10hr  (6242) embryo 10-12hr  (5513) embryo 12-14hr  (3668) embryo 14-16hr  (3818) embryo 16-18hr  (3120) embryo 18-20hr  (3090) embryo 20-22hr  (2919) embryo 22-24hr  (2959) larva L1  (4090) larva L2  (4403) larva L3 12hr old  (3153) larva L3 puffstage 1-2  (4876) larva L3 puffstage 3-6  (5447) larva L3 puffstage 7-9  (6133) white prepupae new  (6374) white prepupae 12hr  (5133) white prepupae 24hr  (6349) pupae 2d postWPP  (5273) pupae 3d postWPP  (3326) pupae 4d postWPP  (3485) adult male 01day  (3274) adult male 05day  (3996) adult male 30day  (4527) adult female 01day  (4322) adult female 05day  (4576) adult female 30day  (4786) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5771) embryo 02-04hr  (6269) embryo 04-06hr  (8548) embryo 06-08hr  (7052) embryo 08-10hr  (6242) embryo 10-12hr  (5513) embryo 12-14hr  (3668) embryo 14-16hr  (3818) embryo 16-18hr  (3120) embryo 18-20hr  (3090) embryo 20-22hr  (2919) embryo 22-24hr  (2959) larva L1  (4090) larva L2  (4403) larva L3 12hr old  (3153) larva L3 puffstage 1-2  (4876) larva L3 puffstage 3-6  (5447) larva L3 puffstage 7-9  (6133) white prepupae new  (6374) white prepupae 12hr  (5133) white prepupae 24hr  (6349) pupae 2d postWPP  (5273) pupae 3d postWPP  (3326) pupae 4d postWPP  (3485) adult male 01day  (3274) adult male 05day  (3996) adult male 30day  (4527) adult female 01day  (4322) adult female 05day  (4576) adult female 30day  (4786) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5771 embryo 02-04hr    6269 embryo 04-06hr    8548 embryo 06-08hr    7052 embryo 08-10hr    6242 embryo 10-12hr    5513 embryo 12-14hr    3668 embryo 14-16hr    3818 embryo 16-18hr    3120 embryo 18-20hr    3090 embryo 20-22hr    2919 embryo 22-24hr    2959 larva L1    4090 larva L2    4403 larva L3 12hr old    3153 larva L3 puffstage 1-2    4876 larva L3 puffstage 3-6    5447 larva L3 puffstage 7-9    6133 white prepupae new    6374 white prepupae 12hr    5133 white prepupae 24hr    6349 pupae 2d postWPP    5273 pupae 3d postWPP    3326 pupae 4d postWPP    3485 adult male 01day    3274 adult male 05day    3996 adult male 30day    4527 adult female 01day    4322 adult female 05day    4576 adult female 30day    4786 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5771 embryo 02-04hr    6269 embryo 04-06hr    8548 embryo 06-08hr    7052 embryo 08-10hr    6242 embryo 10-12hr    5513 embryo 12-14hr    3668 embryo 14-16hr    3818 embryo 16-18hr    3120 embryo 18-20hr    3090 embryo 20-22hr    2919 embryo 22-24hr    2959 larva L1    4090 larva L2    4403 larva L3 12hr old    3153 larva L3 puffstage 1-2    4876 larva L3 puffstage 3-6    5447 larva L3 puffstage 7-9    6133 white prepupae new    6374 white prepupae 12hr    5133 white prepupae 24hr    6349 pupae 2d postWPP    5273 pupae 3d postWPP    3326 pupae 4d postWPP    3485 adult male 01day    3274 adult male 05day    3996 adult male 30day    4527 adult female 01day    4322 adult female 05day    4576 adult female 30day    4786 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031437 expression level Developmental Stage   Expression Level embryo 00-02hr    5771 embryo 02-04hr    6269 embryo 04-06hr    8548 embryo 06-08hr    7052 embryo 08-10hr    6242 embryo 10-12hr    5513 embryo 12-14hr    3668 embryo 14-16hr    3818 embryo 16-18hr    3120 embryo 18-20hr    3090 embryo 20-22hr    2919 embryo 22-24hr    2959 larva L1    4090 larva L2    4403 larva L3 12hr old    3153 larva L3 puffstage 1-2    4876 larva L3 puffstage 3-6    5447 larva L3 puffstage 7-9    6133 white prepupae new    6374 white prepupae 12hr    5133 white prepupae 24hr    6349 pupae 2d postWPP    5273 pupae 3d postWPP    3326 pupae 4d postWPP    3485 adult male 01day    3274 adult male 05day    3996 adult male 30day    4527 adult female 01day    4322 adult female 05day    4576 adult female 30day    4786 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5771) embryo 02-04hr  (6269) embryo 04-06hr  (8548) embryo 06-08hr  (7052) embryo 08-10hr  (6242) embryo 10-12hr  (5513) embryo 12-14hr  (3668) embryo 14-16hr  (3818) embryo 16-18hr  (3120) embryo 18-20hr  (3090) embryo 20-22hr  (2919) embryo 22-24hr  (2959) larva L1  (4090) larva L2  (4403) larva L3 12hr old  (3153) larva L3 puffstage 1-2  (4876) larva L3 puffstage 3-6  (5447) larva L3 puffstage 7-9  (6133) white prepupae new  (6374) white prepupae 12hr  (5133) white prepupae 24hr  (6349) pupae 2d postWPP  (5273) pupae 3d postWPP  (3326) pupae 4d postWPP  (3485) adult male 01day  (3274) adult male 05day  (3996) adult male 30day  (4527) adult female 01day  (4322) adult female 05day  (4576) adult female 30day  (4786) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5771) embryo 02-04hr  (6269) embryo 04-06hr  (8548) embryo 06-08hr  (7052) embryo 08-10hr  (6242) embryo 10-12hr  (5513) embryo 12-14hr  (3668) embryo 14-16hr  (3818) embryo 16-18hr  (3120) embryo 18-20hr  (3090) embryo 20-22hr  (2919) embryo 22-24hr  (2959) larva L1  (4090) larva L2  (4403) larva L3 12hr old  (3153) larva L3 puffstage 1-2  (4876) larva L3 puffstage 3-6  (5447) larva L3 puffstage 7-9  (6133) white prepupae new  (6374) white prepupae 12hr  (5133) white prepupae 24hr  (6349) pupae 2d postWPP  (5273) pupae 3d postWPP  (3326) pupae 4d postWPP  (3485) adult male 01day  (3274) adult male 05day  (3996) adult male 30day  (4527) adult female 01day  (4322) adult female 05day  (4576) adult female 30day  (4786) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5771 embryo 02-04hr    6269 embryo 04-06hr    8548 embryo 06-08hr    7052 embryo 08-10hr    6242 embryo 10-12hr    5513 embryo 12-14hr    3668 embryo 14-16hr    3818 embryo 16-18hr    3120 embryo 18-20hr    3090 embryo 20-22hr    2919 embryo 22-24hr    2959 larva L1    4090 larva L2    4403 larva L3 12hr old    3153 larva L3 puffstage 1-2    4876 larva L3 puffstage 3-6    5447 larva L3 puffstage 7-9    6133 white prepupae new    6374 white prepupae 12hr    5133 white prepupae 24hr    6349 pupae 2d postWPP    5273 pupae 3d postWPP    3326 pupae 4d postWPP    3485 adult male 01day    3274 adult male 05day    3996 adult male 30day    4527 adult female 01day    4322 adult female 05day    4576 adult female 30day    4786 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5771 embryo 02-04hr    6269 embryo 04-06hr    8548 embryo 06-08hr    7052 embryo 08-10hr    6242 embryo 10-12hr    5513 embryo 12-14hr    3668 embryo 14-16hr    3818 embryo 16-18hr    3120 embryo 18-20hr    3090 embryo 20-22hr    2919 embryo 22-24hr    2959 larva L1    4090 larva L2    4403 larva L3 12hr old    3153 larva L3 puffstage 1-2    4876 larva L3 puffstage 3-6    5447 larva L3 puffstage 7-9    6133 white prepupae new    6374 white prepupae 12hr    5133 white prepupae 24hr    6349 pupae 2d postWPP    5273 pupae 3d postWPP    3326 pupae 4d postWPP    3485 adult male 01day    3274 adult male 05day    3996 adult male 30day    4527 adult female 01day    4322 adult female 05day    4576 adult female 30day    4786 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031437    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031437 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031437 expression level Tissue   Expression Level Larval Central Nervous System    276.65 Larval Midgut    492 Larval Hindgut    366.6 Larval Malpighian Tubules    537.4 Larval Fat Body    271.3 Larval Salivary Gland    479.7 Larval Trachea    457.375 Larval Carcass    245.475 Adult Head    152.9 Adult Eye    210.525 Adult Brain    162.6 Adult Thoracic-Abdominal Ganglion    146.2 Adult Crop    275.6 Adult Midgut    409.1 Adult Hindgut    254 Adult Malpighian Tubules    453.6 Adult Fat Body    89.6 Adult Salivary Gland    255.9 Adult Heart    205.375 Adult VirginFemale Spermatheca    173.3 Adult InseminatedFemale Spermatheca    187.1 Adult Ovary    271.2 Adult Testis    274.2 Adult Male Accessory Gland    308.4 Adult Carcass    124.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    276.65 Larval Midgut    492 Larval Hindgut    366.6 Larval Malpighian Tubules  537.4 Larval Fat Body    271.3 Larval Salivary Gland    479.7 Larval Trachea    457.375 Larval Carcass    245.475 Adult Head    152.9 Adult Eye    210.525 Adult Brain    162.6 Adult Thoracic-Abdominal Ganglion    146.2 Adult Crop    275.6 Adult Midgut    409.1 Adult Hindgut    254 Adult Malpighian Tubules    453.6 Adult Fat Body    89.6 Adult Salivary Gland    255.9 Adult Heart    205.375 Adult VirginFemale Spermatheca    173.3 Adult InseminatedFemale Spermatheca    187.1 Adult Ovary    271.2 Adult Testis    274.2 Adult Male Accessory Gland    308.4 Adult Carcass    124.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    276.65 Larval Midgut    492 Larval Hindgut    366.6 Larval Malpighian Tubules    537.4 Larval Fat Body    271.3 Larval Salivary Gland    479.7 Larval Trachea    457.375 Larval Carcass    245.475 Adult Head    152.9 Adult Eye    210.525 Adult Brain    162.6 Adult Thoracic-Abdominal Ganglion    146.2 Adult Crop    275.6 Adult Midgut    409.1 Adult Hindgut    254 Adult Malpighian Tubules    453.6 Adult Fat Body    89.6 Adult Salivary Gland    255.9 Adult Heart    205.375 Adult VirginFemale Spermatheca    173.3 Adult InseminatedFemale Spermatheca    187.1 Adult Ovary    271.2 Adult Testis    274.2 Adult Male Accessory Gland    308.4 Adult Carcass    124.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    276.65 Larval Midgut    492 Larval Hindgut    366.6 Larval Malpighian Tubules    537.4 Larval Fat Body    271.3 Larval Salivary Gland    479.7 Larval Trachea    457.375 Larval Carcass    245.475 Adult Head    152.9 Adult Eye    210.525 Adult Brain    162.6 Adult Thoracic-Abdominal Ganglion    146.2 Adult Crop    275.6 Adult Midgut    409.1 Adult Hindgut    254 Adult Malpighian Tubules    453.6 Adult Fat Body    89.6 Adult Salivary Gland    255.9 Adult Heart    205.375 Adult VirginFemale Spermatheca    173.3 Adult InseminatedFemale Spermatheca    187.1 Adult Ovary    271.2 Adult Testis    274.2 Adult Male Accessory Gland    308.4 Adult Carcass    124.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031437 expression level Tissue   Expression Level Larval Central Nervous System    276.65 Larval Midgut    492 Larval Hindgut    366.6 Larval Malpighian Tubules    537.4 Larval Fat Body    271.3 Larval Salivary Gland    479.7 Larval Trachea    457.375 Larval Carcass    245.475 Adult Head    152.9 Adult Eye    210.525 Adult Brain    162.6 Adult Thoracic-Abdominal Ganglion    146.2 Adult Crop    275.6 Adult Midgut    409.1 Adult Hindgut    254 Adult Malpighian Tubules    453.6 Adult Fat Body    89.6 Adult Salivary Gland    255.9 Adult Heart    205.375 Adult VirginFemale Spermatheca    173.3 Adult InseminatedFemale Spermatheca    187.1 Adult Ovary    271.2 Adult Testis    274.2 Adult Male Accessory Gland    308.4 Adult Carcass    124.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    276.65 Larval Midgut    492 Larval Hindgut    366.6 Larval Malpighian Tubules  537.4 Larval Fat Body    271.3 Larval Salivary Gland    479.7 Larval Trachea    457.375 Larval Carcass    245.475 Adult Head    152.9 Adult Eye    210.525 Adult Brain    162.6 Adult Thoracic-Abdominal Ganglion    146.2 Adult Crop    275.6 Adult Midgut    409.1 Adult Hindgut    254 Adult Malpighian Tubules    453.6 Adult Fat Body    89.6 Adult Salivary Gland    255.9 Adult Heart    205.375 Adult VirginFemale Spermatheca    173.3 Adult InseminatedFemale Spermatheca    187.1 Adult Ovary    271.2 Adult Testis    274.2 Adult Male Accessory Gland    308.4 Adult Carcass    124.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    276.65 Larval Midgut    492 Larval Hindgut    366.6 Larval Malpighian Tubules    537.4 Larval Fat Body    271.3 Larval Salivary Gland    479.7 Larval Trachea    457.375 Larval Carcass    245.475 Adult Head    152.9 Adult Eye    210.525 Adult Brain    162.6 Adult Thoracic-Abdominal Ganglion    146.2 Adult Crop    275.6 Adult Midgut    409.1 Adult Hindgut    254 Adult Malpighian Tubules    453.6 Adult Fat Body    89.6 Adult Salivary Gland    255.9 Adult Heart    205.375 Adult VirginFemale Spermatheca    173.3 Adult InseminatedFemale Spermatheca    187.1 Adult Ovary    271.2 Adult Testis    274.2 Adult Male Accessory Gland    308.4 Adult Carcass    124.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    276.65 Larval Midgut    492 Larval Hindgut    366.6 Larval Malpighian Tubules    537.4 Larval Fat Body    271.3 Larval Salivary Gland    479.7 Larval Trachea    457.375 Larval Carcass    245.475 Adult Head    152.9 Adult Eye    210.525 Adult Brain    162.6 Adult Thoracic-Abdominal Ganglion    146.2 Adult Crop    275.6 Adult Midgut    409.1 Adult Hindgut    254 Adult Malpighian Tubules    453.6 Adult Fat Body    89.6 Adult Salivary Gland    255.9 Adult Heart    205.375 Adult VirginFemale Spermatheca    173.3 Adult InseminatedFemale Spermatheca    187.1 Adult Ovary    271.2 Adult Testis    274.2 Adult Male Accessory Gland    308.4 Adult Carcass    124.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    152.9   NA  Eye    210.525   NA  Brain    162.6   276.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    146.2   NA  Crop    275.6   492  Midgut    409.1   366.6  Hindgut    254   537.4  Malpighian Tubules    453.6   271.3  Fat Body    89.6   479.7  Salivary Gland    255.9   NA  Heart    205.375   457.375  Trachea    NA   NA  VirginFemale Spermatheca    173.3   NA  InseminatedFemale Spermatheca    187.1   NA  Ovary    271.2   NA  Testis    274.2   NA  Male Accessory Gland    308.4   245.475  Carcass    124.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031437 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9881-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 p16-ARCGD12571 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of p16-ARC Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of p16-ARC Class Mutagen Stocks Known lesion p16-ARCGD12571 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes p16-ARCJF03147 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes p16-ARCKK109147 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6008 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12571} NA P{KK109147} NA P{TRiP.JF03147} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell morphogenesis inferred from mutant phenotype (D'Ambrosio and Vale, 2010) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component
CV term Evidence References
lamellipodium inferred from direct assay (Iwasa and Mullins, 2007)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
regulation of actin filament polymerization inferred from electronic annotation with InterPro:IPR006789 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cytoskeleton inferred from electronic annotation with InterPro:IPR006789 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions p16-ARC allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59671 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031437 DroID - A comprehensive database of gene and protein interactions. • FBgn0031437 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33444
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20591 Dere\GG24865 Dgri\GH11156 Dmoj\GI17862 Dper\GL26566 Dpse\GA22095 Dsec\GM18347 Dsim\GD23162 Dvir\GJ17361 Dwil\GK24566 Dyak\GE18163
Curated drosophilid orthologs	Dpse\GA22095
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009059-PA Aedes aegypti (mosquito) AGAP008895-PA Anopheles gambiae (mosquito) XP_001119861.1 Apis mellifera (honey bee) XP_001950711.1 Acyrthosiphon pisum (pea aphid) At4g01710.1 Arabidopsis thaliana (wall cress) 26639 Batrachochytrium dendrobatidis (chytrid fungus) 114681 Branchiostoma floridae (lancelet) XP_001892979.1 Brugia malayi (roundworm nematode) BGIBMGA005922-PA Bombyx mori (silk worm) ENSBTAP00000020318 Bos taurus (bovine) CAL0006043 Candida albicans (a form of yeast) CBP00979 Caenorhabditis briggsae (nematode) CE18061 Caenorhabditis elegans (worm) ENSCAFP00000019669 Canis familiaris (dog) ENSCAFP00000029979 Canis familiaris (dog) CAGL0M12595g Candida glabrata (haploid yeast) cn01299 Cryptococcus neoformans (yeast-like fungus) CPIJ012795 Culex pipens (mosquito) ENSCPOP00000013249 Cavia porcellus (guinea pig) RP25207 Caenorhabditis remanei (nematode) 17923 Capitella spl (polychaete worm) DDB0191138 Dictyostelium discoideum (amoeba) DEHA2F13112g Debaryomyces Hansenii (yeast) 305421 Daphnia pulex (daphnia) ENSDARP00000025370 Danio rerio (zebra fish) ENSECAP00000016615 Equus caballus (horse) ENSGACP00000009769 Gymnopilus aculeatus (mushroom) ENSGALP00000001494 Gallus gallus (chicken) 105985 Hypsipyla robusta (cedar shoot borer) ENSP00000345361 Homo sapiens (human) ISCW017220-PA Ixodes scapularis (deer tick) KLLA0C07975g Kluyveromyces lactis (yeast) 172988 Lottia gigantea (owl limpet) ENSMODP00000008916 Monodelphis domestica (gray opossum) ENSMMUP00000027157 Macaca mulatta (rhesus monkey) ENSMUSP00000076933 Mus musculus (house mouse) 182709 Nematostella vectensis (starlet anemone) ENSOANP00000001589 Ornithorynchus anatinus (platypus) ENSORLP00000011905 Oryzias latipes (japanese killifish) LOC_Os11g35360.1 Oryza sativa (asian rice) PHUM007014-PA Pediculus humanus (human body louse) 106518 Physcomitrella patens (moss) ENSPPYP00000000483 Pongo pygmaeus (orangutan) 72632 Phytophthora ramorum (sudden oak death pathogen) 826736 Populus trichocarpa (black cottonwood) 830323 Populus trichocarpa (black cottonwood) ENSPTRP00000036509 Pan troglodytes (chimpanzee) ENSRNOP00000021996 Rattus norvegicus (norway rat) 5005671 Sorghum bicolor (sorghum) YIL062C Saccharomyces cerevisiae (budding yeast) Smp_073720.2 Schistosoma mansoni (trematode parasite) SPAC17G8.04c Schizosaccharomyces pombe (fission yeast) 53486 Trichoplax adhaerens (metazoa) XP_970790.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021292 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000013152 Takifugu rubripes (pufferfish Takifugu) 94275.m00100 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000053136 Xenopus tropicalis (frog) YALI0E10857g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV23060 LH24325 ISCW017220 FBgn0235595 FBgn0226526 FBgn0204533 FBgn0194551 FBgn0173254 JGI_V11_305421 FBgn0082079 FBgn0164148 FBgn0140603 FBgn0118637 FBgn0116994 FBgn0097597 CPIJ012795 BGIBMGA005922 ACYPI002248 GB12977 AGAP008895 AAEL009059 PB25167 PHUM137530 GLEAN_13790
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	28720 y1 v1; P{TRiP.JF03147}attP2
VDRC	v102012 P{KK109147}VIE-260B v28141 w1118; P{GD12571}v28141
Genomic Clones ( 2 )
	BACR30P05 BACR34M11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 33 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT14664 RH48239
Other clones	DPiM_RH48239
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT16675 GM20470 LD33206 LD37902 LP08710 RH54435 RH59006
Other clones	bs05f01 bs39c12 EK182721 FGB001F06 FGH102C02 FGH106A10 FGH114B11 FGM104A10 FGM211C06 FGM222E11 FGM225H11 FGM303G03 RP004044269 RP004205087 RP004217292 RP004223616 RP004227908 RP004254273 RP004293494 RP004349238 RP004425877 RP004487262 RP004519977
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031437 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33444
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: p16-ARC CG9881 (Goldstein and Gunawardena, 2000)
Source for database merge of
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134849 RefSeq (Proteins) • NP_608693 DDBJ / EMBL / GenBank • AAF51237 AAL90416 AI295159 AI944798 AY089678 BI617798 Entrez Gene - A searchable database of RefSeq genes. • 33444 UniProtKB/TrEMBL • Q9VQD8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ARP2/3 complex 16kDa subunit (p16-Arc) (IPR006789)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59671 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031437 DroID - A comprehensive database of gene and protein interactions. • FBgn0031437 DRSC - Results from RNAi screens. • FBgn0031437 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031437 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9881-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031437 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33444 InParanoid A subset of ortholog calls from InParanoid. • AAEL009059-PA Aedes aegypti (mosquito) AGAP008895-PA Anopheles gambiae (mosquito) XP_001119861.1 Apis mellifera (honey bee) XP_001950711.1 Acyrthosiphon pisum (pea aphid) At4g01710.1 Arabidopsis thaliana (wall cress) 26639 Batrachochytrium dendrobatidis (chytrid fungus) 114681 Branchiostoma floridae (lancelet) XP_001892979.1 Brugia malayi (roundworm nematode) BGIBMGA005922-PA Bombyx mori (silk worm) ENSBTAP00000020318 Bos taurus (bovine) CAL0006043 Candida albicans (a form of yeast) CBP00979 Caenorhabditis briggsae (nematode) CE18061 Caenorhabditis elegans (worm) ENSCAFP00000019669 Canis familiaris (dog) ENSCAFP00000029979 Canis familiaris (dog) CAGL0M12595g Candida glabrata (haploid yeast) cn01299 Cryptococcus neoformans (yeast-like fungus) CPIJ012795 Culex pipens (mosquito) ENSCPOP00000013249 Cavia porcellus (guinea pig) RP25207 Caenorhabditis remanei (nematode) 17923 Capitella spl (polychaete worm) DDB0191138 Dictyostelium discoideum (amoeba) DEHA2F13112g Debaryomyces Hansenii (yeast) 305421 Daphnia pulex (daphnia) ENSDARP00000025370 Danio rerio (zebra fish) ENSECAP00000016615 Equus caballus (horse) ENSGACP00000009769 Gymnopilus aculeatus (mushroom) ENSGALP00000001494 Gallus gallus (chicken) 105985 Hypsipyla robusta (cedar shoot borer) ENSP00000345361 Homo sapiens (human) ISCW017220-PA Ixodes scapularis (deer tick) KLLA0C07975g Kluyveromyces lactis (yeast) 172988 Lottia gigantea (owl limpet) ENSMODP00000008916 Monodelphis domestica (gray opossum) ENSMMUP00000027157 Macaca mulatta (rhesus monkey) ENSMUSP00000076933 Mus musculus (house mouse) 182709 Nematostella vectensis (starlet anemone) ENSOANP00000001589 Ornithorynchus anatinus (platypus) ENSORLP00000011905 Oryzias latipes (japanese killifish) LOC_Os11g35360.1 Oryza sativa (asian rice) PHUM007014-PA Pediculus humanus (human body louse) 106518 Physcomitrella patens (moss) ENSPPYP00000000483 Pongo pygmaeus (orangutan) 72632 Phytophthora ramorum (sudden oak death pathogen) 826736 Populus trichocarpa (black cottonwood) 830323 Populus trichocarpa (black cottonwood) ENSPTRP00000036509 Pan troglodytes (chimpanzee) ENSRNOP00000021996 Rattus norvegicus (norway rat) 5005671 Sorghum bicolor (sorghum) YIL062C Saccharomyces cerevisiae (budding yeast) Smp_073720.2 Schistosoma mansoni (trematode parasite) SPAC17G8.04c Schizosaccharomyces pombe (fission yeast) 53486 Trichoplax adhaerens (metazoa) XP_970790.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021292 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000013152 Takifugu rubripes (pufferfish Takifugu) 94275.m00100 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000053136 Xenopus tropicalis (frog) YALI0E10857g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33444 modMine - Data generated by the modENCODE project. • FBgn0031437 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV23060 LH24325 ISCW017220 FBgn0235595 FBgn0226526 FBgn0204533 FBgn0194551 FBgn0173254 JGI_V11_305421 FBgn0082079 FBgn0164148 FBgn0140603 FBgn0118637 FBgn0116994 FBgn0097597 CPIJ012795 BGIBMGA005922 ACYPI002248 GB12977 AGAP008895 AAEL009059 PB25167 PHUM137530 GLEAN_13790
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Arpc5 (Beltzner and Pollard, 2004) CG9881 (Goldstein and Gunawardena, 2000, Keleman et al., 2009.8.5, Perkins et al., 2009, Brandt, 2006) p16 (Iwasa and Mullins, 2007) P16-ARC (Goldstein and Gunawardena, 2000, D'Ambrosio and Vale, 2010) p16-ARC (Stroschein-Stevenson et al., 2006, Bakal et al., 2007, Brandt, 2006, Engström et al., 2007)
Name Synonym	p16-ARC
Secondary FlyBase IDs
References ( 23 )
Generate a list of	All references relating to this gene ( 23 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478 A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. [FBrf0212211] Show all research papers ...