l(2)23Ad, l(2)23AB5, vps27
endosomal sorting of ubiquitinated receptors - targeting of EGFR, PVR, Notch, Hedgehog and Dpp receptors for degradation
Please see the JBrowse view of Dmel\Hrs for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.44
Gene model reviewed during 5.48
Homodimer; in vitro. Interacts with ubiquitin.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hrs using the Feature Mapper tool.
Comment: maternally deposited
Hrs protein is expressed in circulating hemocytes.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Hrs in GBrowse 22-7
2-6.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
Source for identity of: Hrs CG2903
Source for merge of: Hrs l(2)23AB5
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Hrs appears to regulate inward budding of endosome membrane and multivesicular body (MVB) formation.
Identification: Screen for lethals heterozygous with Df(2L)C144.