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Gene Dmel\Trn-SR

General Information
Symbol	Dmel\Trn-SR	Species	D. melanogaster
Name	Transportin-Serine/Arginine rich	Annotation symbol	CG2848
Feature type	protein_coding_gene	FlyBase ID	FBgn0031456
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	23A3-23A5	Sequence location	2L:2,759,915..2,763,610 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Transportin-Serine/Arginine rich is referred to in FlyBase by the symbol Dmel\Trn-SR (CG2848, FBgn0031456). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: splicing factor protein import into nucleus; regulation of nuclear mRNA splicing, via spliceosome; neurogenesis. 6 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Armadillo-like helical; Armadillo-type fold; Exportin-1/Importin-beta-like; Importin-beta, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult salivary gland, adult female reproductive system, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1630732_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Trn-SR. Gene sequence location is 2L:2759915..2763610.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features HFA00546 BKN21801
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 23A3-23A5   Limits computationally determined from genome sequence between P{EP}EP832 and P{PZ}oho23B03575
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Trn-SR for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Trn-SR-RA FBtr0077715  NM_134864   3316   932
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Trn-SR-PA   FBpp0077399   105.8   932   5.69     NP_608708   AAF51214
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Importin-beta, N-terminal (IPR001494) Armadillo-like helical (IPR011989) Exportin-1/Importin-beta-like (IPR013598) Armadillo-type fold (IPR016024)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246414   AA246751   AA391569   AA438934   AA441068   AA735573   AA942190   AA990866   AE014134 AAF51214   AF083512   AI063283   AI388444   AI455163   AI518760   AI546354   AY095186 AAM12279   BH809469   BI169341   BI230292   BI230378   BI232208   BI361768   BI363848   BI365400   BI484976   BI485995   CZ479949
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VQG0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
distribution deduced from reporter or direct label Stage Tissue/Position (including subcellular localization) Reference     • nucleus (Allemand et al., 2002)
Additional Descriptive Data
	The Trn-SR proteinshows a uniform nuclear distribution in cultured S2 cells. (Allemand et al., 2002)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031456    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031456 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031456 expression level Developmental Stage   Expression Level embryo 00-02hr    2421 embryo 02-04hr    3253 embryo 04-06hr    1819 embryo 06-08hr    1793 embryo 08-10hr    1831 embryo 10-12hr    1945 embryo 12-14hr    1144 embryo 14-16hr    1196 embryo 16-18hr    849 embryo 18-20hr    467 embryo 20-22hr    793 embryo 22-24hr    720 larva L1    444 larva L2    423 larva L3 12hr old    353 larva L3 puffstage 1-2    304 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    545 white prepupae new    565 white prepupae 12hr    604 white prepupae 24hr    673 pupae 2d postWPP    496 pupae 3d postWPP    271 pupae 4d postWPP    281 adult male 01day    325 adult male 05day    371 adult male 30day    382 adult female 01day    602 adult female 05day    885 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2421) embryo 02-04hr  (3253) embryo 04-06hr  (1819) embryo 06-08hr  (1793) embryo 08-10hr  (1831) embryo 10-12hr  (1945) embryo 12-14hr  (1144) embryo 14-16hr  (1196) embryo 16-18hr  (849) embryo 18-20hr  (467) embryo 20-22hr  (793) embryo 22-24hr  (720) larva L1  (444) larva L2  (423) larva L3 12hr old  (353) larva L3 puffstage 1-2  (304) larva L3 puffstage 3-6  (478) larva L3 puffstage 7-9  (545) white prepupae new  (565) white prepupae 12hr  (604) white prepupae 24hr  (673) pupae 2d postWPP  (496) pupae 3d postWPP  (271) pupae 4d postWPP  (281) adult male 01day  (325) adult male 05day  (371) adult male 30day  (382) adult female 01day  (602) adult female 05day  (885) adult female 30day  (967) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2421) embryo 02-04hr  (3253) embryo 04-06hr  (1819) embryo 06-08hr  (1793) embryo 08-10hr  (1831) embryo 10-12hr  (1945) embryo 12-14hr    1144 embryo 14-16hr    1196 embryo 16-18hr    849 embryo 18-20hr    467 embryo 20-22hr    793 embryo 22-24hr    720 larva L1    444 larva L2    423 larva L3 12hr old    353 larva L3 puffstage 1-2    304 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    545 white prepupae new    565 white prepupae 12hr    604 white prepupae 24hr    673 pupae 2d postWPP    496 pupae 3d postWPP    271 pupae 4d postWPP    281 adult male 01day    325 adult male 05day    371 adult male 30day    382 adult female 01day    602 adult female 05day    885 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2421 embryo 02-04hr    3253 embryo 04-06hr    1819 embryo 06-08hr    1793 embryo 08-10hr    1831 embryo 10-12hr    1945 embryo 12-14hr    1144 embryo 14-16hr    1196 embryo 16-18hr    849 embryo 18-20hr    467 embryo 20-22hr    793 embryo 22-24hr    720 larva L1    444 larva L2    423 larva L3 12hr old    353 larva L3 puffstage 1-2    304 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    545 white prepupae new    565 white prepupae 12hr    604 white prepupae 24hr    673 pupae 2d postWPP    496 pupae 3d postWPP    271 pupae 4d postWPP    281 adult male 01day    325 adult male 05day    371 adult male 30day    382 adult female 01day    602 adult female 05day    885 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2421 embryo 02-04hr    3253 embryo 04-06hr    1819 embryo 06-08hr    1793 embryo 08-10hr    1831 embryo 10-12hr    1945 embryo 12-14hr    1144 embryo 14-16hr    1196 embryo 16-18hr    849 embryo 18-20hr    467 embryo 20-22hr    793 embryo 22-24hr    720 larva L1    444 larva L2    423 larva L3 12hr old    353 larva L3 puffstage 1-2    304 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    545 white prepupae new    565 white prepupae 12hr    604 white prepupae 24hr    673 pupae 2d postWPP    496 pupae 3d postWPP    271 pupae 4d postWPP    281 adult male 01day    325 adult male 05day    371 adult male 30day    382 adult female 01day    602 adult female 05day    885 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031456 expression level Developmental Stage   Expression Level embryo 00-02hr    2421 embryo 02-04hr    3253 embryo 04-06hr    1819 embryo 06-08hr    1793 embryo 08-10hr    1831 embryo 10-12hr    1945 embryo 12-14hr    1144 embryo 14-16hr    1196 embryo 16-18hr    849 embryo 18-20hr    467 embryo 20-22hr    793 embryo 22-24hr    720 larva L1    444 larva L2    423 larva L3 12hr old    353 larva L3 puffstage 1-2    304 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    545 white prepupae new    565 white prepupae 12hr    604 white prepupae 24hr    673 pupae 2d postWPP    496 pupae 3d postWPP    271 pupae 4d postWPP    281 adult male 01day    325 adult male 05day    371 adult male 30day    382 adult female 01day    602 adult female 05day    885 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2421) embryo 02-04hr  (3253) embryo 04-06hr  (1819) embryo 06-08hr  (1793) embryo 08-10hr  (1831) embryo 10-12hr  (1945) embryo 12-14hr  (1144) embryo 14-16hr  (1196) embryo 16-18hr  (849) embryo 18-20hr  (467) embryo 20-22hr  (793) embryo 22-24hr  (720) larva L1  (444) larva L2  (423) larva L3 12hr old  (353) larva L3 puffstage 1-2  (304) larva L3 puffstage 3-6  (478) larva L3 puffstage 7-9  (545) white prepupae new  (565) white prepupae 12hr  (604) white prepupae 24hr  (673) pupae 2d postWPP  (496) pupae 3d postWPP  (271) pupae 4d postWPP  (281) adult male 01day  (325) adult male 05day  (371) adult male 30day  (382) adult female 01day  (602) adult female 05day  (885) adult female 30day  (967) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2421 embryo 02-04hr  (3253) embryo 04-06hr  1819 embryo 06-08hr  1793 embryo 08-10hr  1831 embryo 10-12hr  1945 embryo 12-14hr    1144 embryo 14-16hr    1196 embryo 16-18hr    849 embryo 18-20hr    467 embryo 20-22hr    793 embryo 22-24hr    720 larva L1    444 larva L2    423 larva L3 12hr old    353 larva L3 puffstage 1-2    304 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    545 white prepupae new    565 white prepupae 12hr    604 white prepupae 24hr    673 pupae 2d postWPP    496 pupae 3d postWPP    271 pupae 4d postWPP    281 adult male 01day    325 adult male 05day    371 adult male 30day    382 adult female 01day    602 adult female 05day    885 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2421 embryo 02-04hr    3253 embryo 04-06hr    1819 embryo 06-08hr    1793 embryo 08-10hr    1831 embryo 10-12hr    1945 embryo 12-14hr    1144 embryo 14-16hr    1196 embryo 16-18hr    849 embryo 18-20hr    467 embryo 20-22hr    793 embryo 22-24hr    720 larva L1    444 larva L2    423 larva L3 12hr old    353 larva L3 puffstage 1-2    304 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    545 white prepupae new    565 white prepupae 12hr    604 white prepupae 24hr    673 pupae 2d postWPP    496 pupae 3d postWPP    271 pupae 4d postWPP    281 adult male 01day    325 adult male 05day    371 adult male 30day    382 adult female 01day    602 adult female 05day    885 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2421 embryo 02-04hr    3253 embryo 04-06hr    1819 embryo 06-08hr    1793 embryo 08-10hr    1831 embryo 10-12hr    1945 embryo 12-14hr    1144 embryo 14-16hr    1196 embryo 16-18hr    849 embryo 18-20hr    467 embryo 20-22hr    793 embryo 22-24hr    720 larva L1    444 larva L2    423 larva L3 12hr old    353 larva L3 puffstage 1-2    304 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    545 white prepupae new    565 white prepupae 12hr    604 white prepupae 24hr    673 pupae 2d postWPP    496 pupae 3d postWPP    271 pupae 4d postWPP    281 adult male 01day    325 adult male 05day    371 adult male 30day    382 adult female 01day    602 adult female 05day    885 adult female 30day    967 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031456    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031456 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult salivary gland, adult female reproductive system, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031456 expression level Tissue   Expression Level Larval Central Nervous System    143.55 Larval Midgut    57.6 Larval Hindgut    76 Larval Malpighian Tubules    75.2 Larval Fat Body    68.3 Larval Salivary Gland    129.4 Larval Trachea    72.4 Larval Carcass    78.9 Adult Head    65 Adult Eye    62.775 Adult Brain    101.1 Adult Thoracic-Abdominal Ganglion    103.2 Adult Crop    87.1 Adult Midgut    46 Adult Hindgut    58.8 Adult Malpighian Tubules    64.5 Adult Fat Body    76.6 Adult Salivary Gland    153.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    126 Adult Ovary    198.4 Adult Testis    21.6 Adult Male Accessory Gland    108.3 Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    143.55 Larval Midgut    57.6 Larval Hindgut    76 Larval Malpighian Tubules    75.2 Larval Fat Body    68.3 Larval Salivary Gland    129.4 Larval Trachea    72.4 Larval Carcass    78.9 Adult Head    65 Adult Eye    62.775 Adult Brain    101.1 Adult Thoracic-Abdominal Ganglion    103.2 Adult Crop    87.1 Adult Midgut    46 Adult Hindgut    58.8 Adult Malpighian Tubules    64.5 Adult Fat Body    76.6 Adult Salivary Gland    153.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    126 Adult Ovary    198.4 Adult Testis    21.6 Adult Male Accessory Gland    108.3 Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    143.55 Larval Midgut    57.6 Larval Hindgut    76 Larval Malpighian Tubules    75.2 Larval Fat Body    68.3 Larval Salivary Gland    129.4 Larval Trachea    72.4 Larval Carcass    78.9 Adult Head    65 Adult Eye    62.775 Adult Brain    101.1 Adult Thoracic-Abdominal Ganglion    103.2 Adult Crop    87.1 Adult Midgut    46 Adult Hindgut    58.8 Adult Malpighian Tubules    64.5 Adult Fat Body    76.6 Adult Salivary Gland    153.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    126 Adult Ovary    198.4 Adult Testis    21.6 Adult Male Accessory Gland    108.3 Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    143.55 Larval Midgut    57.6 Larval Hindgut    76 Larval Malpighian Tubules    75.2 Larval Fat Body    68.3 Larval Salivary Gland    129.4 Larval Trachea    72.4 Larval Carcass    78.9 Adult Head    65 Adult Eye    62.775 Adult Brain    101.1 Adult Thoracic-Abdominal Ganglion    103.2 Adult Crop    87.1 Adult Midgut    46 Adult Hindgut    58.8 Adult Malpighian Tubules    64.5 Adult Fat Body    76.6 Adult Salivary Gland    153.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    126 Adult Ovary    198.4 Adult Testis    21.6 Adult Male Accessory Gland    108.3 Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031456 expression level Tissue   Expression Level Larval Central Nervous System    143.55 Larval Midgut    57.6 Larval Hindgut    76 Larval Malpighian Tubules    75.2 Larval Fat Body    68.3 Larval Salivary Gland    129.4 Larval Trachea    72.4 Larval Carcass    78.9 Adult Head    65 Adult Eye    62.775 Adult Brain    101.1 Adult Thoracic-Abdominal Ganglion    103.2 Adult Crop    87.1 Adult Midgut    46 Adult Hindgut    58.8 Adult Malpighian Tubules    64.5 Adult Fat Body    76.6 Adult Salivary Gland    153.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    126 Adult Ovary    198.4 Adult Testis    21.6 Adult Male Accessory Gland    108.3 Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    143.55 Larval Midgut    57.6 Larval Hindgut    76 Larval Malpighian Tubules    75.2 Larval Fat Body    68.3 Larval Salivary Gland    129.4 Larval Trachea    72.4 Larval Carcass    78.9 Adult Head    65 Adult Eye    62.775 Adult Brain    101.1 Adult Thoracic-Abdominal Ganglion    103.2 Adult Crop    87.1 Adult Midgut    46 Adult Hindgut    58.8 Adult Malpighian Tubules    64.5 Adult Fat Body    76.6 Adult Salivary Gland    153.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    126 Adult Ovary    198.4 Adult Testis    21.6 Adult Male Accessory Gland    108.3 Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    143.55 Larval Midgut    57.6 Larval Hindgut    76 Larval Malpighian Tubules    75.2 Larval Fat Body    68.3 Larval Salivary Gland    129.4 Larval Trachea    72.4 Larval Carcass    78.9 Adult Head    65 Adult Eye    62.775 Adult Brain    101.1 Adult Thoracic-Abdominal Ganglion    103.2 Adult Crop    87.1 Adult Midgut    46 Adult Hindgut    58.8 Adult Malpighian Tubules    64.5 Adult Fat Body    76.6 Adult Salivary Gland    153.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    126 Adult Ovary    198.4 Adult Testis    21.6 Adult Male Accessory Gland    108.3 Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    143.55 Larval Midgut    57.6 Larval Hindgut    76 Larval Malpighian Tubules    75.2 Larval Fat Body    68.3 Larval Salivary Gland    129.4 Larval Trachea    72.4 Larval Carcass    78.9 Adult Head    65 Adult Eye    62.775 Adult Brain    101.1 Adult Thoracic-Abdominal Ganglion    103.2 Adult Crop    87.1 Adult Midgut    46 Adult Hindgut    58.8 Adult Malpighian Tubules    64.5 Adult Fat Body    76.6 Adult Salivary Gland    153.6 Adult Heart    45.925 Adult VirginFemale Spermatheca    94.8 Adult InseminatedFemale Spermatheca    126 Adult Ovary    198.4 Adult Testis    21.6 Adult Male Accessory Gland    108.3 Adult Carcass    47.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    65   NA  Eye    62.775   NA  Brain    101.1   143.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    103.2   NA  Crop    87.1   57.6  Midgut    46   76  Hindgut    58.8   75.2  Malpighian Tubules    64.5   68.3  Fat Body    76.6   129.4  Salivary Gland    153.6   NA  Heart    45.925   72.4  Trachea    NA   NA  VirginFemale Spermatheca    94.8   NA  InseminatedFemale Spermatheca    126   NA  Ovary    198.4   NA  Testis    21.6   NA  Male Accessory Gland    108.3   78.9  Carcass    47.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031456 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2848-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 Trn-SRGD9833 lethal | pupal stage, with Scer\GAL4pnr-MD237 Trn-SRGD9833 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Trn-SRGD9833 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 Trn-SRGD9833 visible, with Scer\GAL4pnr-MD237 Trn-SRGD9833 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 Trn-SRGD9833 ganglion mother cell | larval stage, with Scer\GAL41407 Trn-SRGD9833 mesothoracic tergum, with Scer\GAL4pnr-MD237 Trn-SRGD9833 trichogen cell, with Scer\GAL4pnr-MD237 Trn-SRGD9833
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Trn-SR Class Mutagen Stocks Known lesion Trn-SRKG04870 P-element activity 2 -- Trn-SRe02124 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Trn-SR Class Mutagen Stocks Known lesion Trn-SRGD9833 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes Trn-SRJF02010 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Trn-SRT:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes Trn-SRΔN217.T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6277 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9833} NA P{TRiP.JF02010} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}Trn-SRKG04870 NA PBac{RB}Trn-SRe02124 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with B52 (Allemand et al., 2002) inferred from physical interaction with Rbp1 (Allemand et al., 2002) inferred from physical interaction with SC35 (Allemand et al., 2002) inferred from physical interaction with SF2 (Allemand et al., 2002) inferred from physical interaction with x16 (Allemand et al., 2002)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) regulation of nuclear mRNA splicing, via spliceosome inferred from physical interaction with B52 (Allemand et al., 2002) inferred from physical interaction with Rbp1 (Allemand et al., 2002) inferred from physical interaction with SC35 (Allemand et al., 2002) inferred from physical interaction with SF2 (Allemand et al., 2002) inferred from physical interaction with x16 (Allemand et al., 2002) splicing factor protein import into nucleus inferred from direct assay (Allemand et al., 2002) inferred from physical interaction with B52 (Allemand et al., 2002) inferred from physical interaction with Rbp1 (Allemand et al., 2002) inferred from physical interaction with SC35 (Allemand et al., 2002) inferred from physical interaction with SF2 (Allemand et al., 2002) inferred from physical interaction with x16 (Allemand et al., 2002)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Allemand et al., 2002) nucleus inferred from direct assay (Allemand et al., 2002)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
protein transporter activity inferred from electronic annotation with InterPro:IPR001494 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mRNA export from nucleus inferred from sequence or structural similarity with UniProtKB:Q99189 (FlyBase, 1992-) protein import into nucleus inferred from sequence or structural similarity with EMBL:AJ133769 (FlyBase, 1992-) inferred from sequence or structural similarity with Saccharomyces MTR10 (Allemand et al., 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Trn-SR allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59688 DroID - A comprehensive database of gene and protein interactions. • FBgn0031456 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33465
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13891 Dere\GG24881 Dgri\GH11168 Dmoj\GI17880 Dper\GL26581 Dpse\GA15483 Dsec\GM18363 Dsim\GD23178 Dvir\GJ17380 Dwil\GK24579 Dyak\GE18178
Curated drosophilid orthologs	Dpse\GA15483
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003573-PA Aedes aegypti (mosquito) AGAP003576-PA Anopheles gambiae (mosquito) XP_001121919.1 Apis mellifera (honey bee) XP_001948005.1 Acyrthosiphon pisum (pea aphid) At5g62600.1 Arabidopsis thaliana (wall cress) 8680 Batrachochytrium dendrobatidis (chytrid fungus) 131385 Branchiostoma floridae (lancelet) ENSBTAP00000006573 Bos taurus (bovine) CAL0001884 Candida albicans (a form of yeast) CN17542 Caenorhabditis brenneri (small nematode) CBP19870 Caenorhabditis briggsae (nematode) CE37021 Caenorhabditis elegans (worm) ENSCAFP00000002231 Canis familiaris (dog) CAGL0L04356g Candida glabrata (haploid yeast) ENSCINP00000010393 Ciona intestinalis (sea squirt) cn14015 Cryptococcus neoformans (yeast-like fungus) CPIJ010425 Culex pipens (mosquito) ENSCPOP00000010737 Cavia porcellus (guinea pig) RP48194 Caenorhabditis remanei (nematode) ENSCSAVP00000014745 Ciona savignyi (sedentary tunicate) 142893 Capitella spl (polychaete worm) DEHA2G07920g Debaryomyces Hansenii (yeast) 323582 Daphnia pulex (daphnia) ENSDARP00000067160 Danio rerio (zebra fish) ENSECAP00000010883 Equus caballus (horse) XP_650523 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000000923 Gymnopilus aculeatus (mushroom) ENSGALP00000022392 Gallus gallus (chicken) 189762 Hypsipyla robusta (cedar shoot borer) ENSP00000352254 Homo sapiens (human) KLLA0A02321g Kluyveromyces lactis (yeast) 177445 Lottia gigantea (owl limpet) 33497 Monocosta brevicollis (choanoflagellate) ENSMODP00000018378 Monodelphis domestica (gray opossum) ENSMMUP00000005765 Macaca mulatta (rhesus monkey) ENSMUSP00000110906 Mus musculus (house mouse) 174976 Nematostella vectensis (starlet anemone) XP_001602761.1 Nasonia vitripennis (wasp) ENSOANP00000018139 Ornithorynchus anatinus (platypus) LOC_Os10g33770.1 Oryza sativa (asian rice) 34982 Ostreococcus tauri (green alga) PHUM001418-PA Pediculus humanus (human body louse) PP01981 Pristionchus pacificus (nematode) 163909 Physcomitrella patens (moss) ENSPPYP00000020183 Pongo pygmaeus (orangutan) 80755 Phytophthora ramorum (sudden oak death pathogen) 133433 Phytophthora sojae (root rot pathogen) 570025 Populus trichocarpa (black cottonwood) ENSPTRP00000039956 Pan troglodytes (chimpanzee) ENSRNOP00000040222 Rattus norvegicus (norway rat) 4869258 Sorghum bicolor (sorghum) YOR160W Saccharomyces cerevisiae (budding yeast) Smp_164410 Schistosoma mansoni (trematode parasite) SPBC11G11.07 Schizosaccharomyces pombe (fission yeast) 54772 Trichoplax adhaerens (metazoa) XP_970238.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005933 Tetraodon nigroviridis (green spotted pufferfish) 21533 Thalassiosira pseudonana (marine diatom) ENSTRUP00000001148 Takifugu rubripes (pufferfish Takifugu) 3725.m00092 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000032823 Xenopus tropicalis (frog) YALI0D01133g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12131 NV11356 LH23564 ISCW023388 ISCW019057 FBgn0235609 FBgn0226539 FBgn0204552 FBgn0194567 FBgn0173270 JGI_V11_323582 FBgn0075500 FBgn0164163 FBgn0140621 FBgn0118649 FBgn0117010 FBgn0090918 CPIJ010425 BGIBMGA008825 ACYPI007398 GB17583 AGAP003576 AAEL003573 PHUM401850 GLEAN_07765
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	25988 y1 v1; P{TRiP.JF02010}attP2 13984 y1; P{SUPor-P}Trn-SRKG04870/CyO; ry506
Harvard	- PBac{RB}Trn-SRe02124
Kyoto	111581 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}Trn-SRKG04870 P{neoFRT}40A/CyO y+
VDRC	v33569 w1118; P{GD9833}v33569 v33571 w1118; P{GD9833}v33571 v40991 w1118; P{GD9833}v40991
Genomic Clones ( 1 )
	BACR42J13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21546
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH19362 LD05393 LD05685 LD10582 LD13333 LD15846 LD26262 LD33723 LD34232 LD38470 LD47914 RE08970 RE10176 RE10484 RE28237 RE46127 RE48811 RE50711 RE68178 RE69360
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031456 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33465
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Trn-SR CG2848 (Allemand et al., 2002)
Source for database merge of	Source for merge of: Trn-SR anon-EST:Posey294 (Ashburner, 2004.6.30)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134864 RefSeq (Proteins) • NP_608708 DDBJ / EMBL / GenBank • AA735573 AAF51214 AAM12279 AF083512 AI455163 AY095186 BH809469 CZ479949 Entrez Gene - A searchable database of RefSeq genes. • 33465 UniProtKB/TrEMBL • Q9VQG0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Importin-beta, N-terminal (IPR001494) Armadillo-like helical (IPR011989) Exportin-1/Importin-beta-like (IPR013598) Armadillo-type fold (IPR016024)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59688 DroID - A comprehensive database of gene and protein interactions. • FBgn0031456 DRSC - Results from RNAi screens. • FBgn0031456 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031456 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2848-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031456 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33465 InParanoid A subset of ortholog calls from InParanoid. • AAEL003573-PA Aedes aegypti (mosquito) AGAP003576-PA Anopheles gambiae (mosquito) XP_001121919.1 Apis mellifera (honey bee) XP_001948005.1 Acyrthosiphon pisum (pea aphid) At5g62600.1 Arabidopsis thaliana (wall cress) 8680 Batrachochytrium dendrobatidis (chytrid fungus) 131385 Branchiostoma floridae (lancelet) ENSBTAP00000006573 Bos taurus (bovine) CAL0001884 Candida albicans (a form of yeast) CN17542 Caenorhabditis brenneri (small nematode) CBP19870 Caenorhabditis briggsae (nematode) CE37021 Caenorhabditis elegans (worm) ENSCAFP00000002231 Canis familiaris (dog) CAGL0L04356g Candida glabrata (haploid yeast) ENSCINP00000010393 Ciona intestinalis (sea squirt) cn14015 Cryptococcus neoformans (yeast-like fungus) CPIJ010425 Culex pipens (mosquito) ENSCPOP00000010737 Cavia porcellus (guinea pig) RP48194 Caenorhabditis remanei (nematode) ENSCSAVP00000014745 Ciona savignyi (sedentary tunicate) 142893 Capitella spl (polychaete worm) DEHA2G07920g Debaryomyces Hansenii (yeast) 323582 Daphnia pulex (daphnia) ENSDARP00000067160 Danio rerio (zebra fish) ENSECAP00000010883 Equus caballus (horse) XP_650523 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000000923 Gymnopilus aculeatus (mushroom) ENSGALP00000022392 Gallus gallus (chicken) 189762 Hypsipyla robusta (cedar shoot borer) ENSP00000352254 Homo sapiens (human) KLLA0A02321g Kluyveromyces lactis (yeast) 177445 Lottia gigantea (owl limpet) 33497 Monocosta brevicollis (choanoflagellate) ENSMODP00000018378 Monodelphis domestica (gray opossum) ENSMMUP00000005765 Macaca mulatta (rhesus monkey) ENSMUSP00000110906 Mus musculus (house mouse) 174976 Nematostella vectensis (starlet anemone) XP_001602761.1 Nasonia vitripennis (wasp) ENSOANP00000018139 Ornithorynchus anatinus (platypus) LOC_Os10g33770.1 Oryza sativa (asian rice) 34982 Ostreococcus tauri (green alga) PHUM001418-PA Pediculus humanus (human body louse) PP01981 Pristionchus pacificus (nematode) 163909 Physcomitrella patens (moss) ENSPPYP00000020183 Pongo pygmaeus (orangutan) 80755 Phytophthora ramorum (sudden oak death pathogen) 133433 Phytophthora sojae (root rot pathogen) 570025 Populus trichocarpa (black cottonwood) ENSPTRP00000039956 Pan troglodytes (chimpanzee) ENSRNOP00000040222 Rattus norvegicus (norway rat) 4869258 Sorghum bicolor (sorghum) YOR160W Saccharomyces cerevisiae (budding yeast) Smp_164410 Schistosoma mansoni (trematode parasite) SPBC11G11.07 Schizosaccharomyces pombe (fission yeast) 54772 Trichoplax adhaerens (metazoa) XP_970238.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005933 Tetraodon nigroviridis (green spotted pufferfish) 21533 Thalassiosira pseudonana (marine diatom) ENSTRUP00000001148 Takifugu rubripes (pufferfish Takifugu) 3725.m00092 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000032823 Xenopus tropicalis (frog) YALI0D01133g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/transportin-sr1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33465 modMine - Data generated by the modENCODE project. • FBgn0031456 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12131 NV11356 LH23564 ISCW023388 ISCW019057 FBgn0235609 FBgn0226539 FBgn0204552 FBgn0194567 FBgn0173270 JGI_V11_323582 FBgn0075500 FBgn0164163 FBgn0140621 FBgn0118649 FBgn0117010 FBgn0090918 CPIJ010425 BGIBMGA008825 ACYPI007398 GB17583 AGAP003576 AAEL003573 PHUM401850 GLEAN_07765
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	anon-EST:Posey294   CG2848 (Ashburner, 2004.6.30, Allemand et al., 2002, Giot et al., 2003, Pilot et al., 2006, Perkins et al., 1.15.2009, Liebl and Featherstone, 2005) dTRN-SR (Allemand et al., 2002) Trn-SR (Lecuyer et al., 2007, Juhasz et al., 2007, Chan et al., 2011, Neumüller et al., 2011)
Name Synonym	Transportin-Serine/Arginine rich (Allemand et al., 2002)
Secondary FlyBase IDs
	FBgn0025293
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Chan et al., 2011, Hum. Mol. Genet. 20(9): 1738--1750 Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. [FBrf0214367] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Show all research papers ...